PE20070175A1 - DERIVATIVES OF N - [(1,5-DIPHENYL-1H-PIRAZOL-3-IL) METHYL] SULFONAMIDE AND ITS PREPARATION - Google Patents

DERIVATIVES OF N - [(1,5-DIPHENYL-1H-PIRAZOL-3-IL) METHYL] SULFONAMIDE AND ITS PREPARATION

Info

Publication number
PE20070175A1
PE20070175A1 PE2006000807A PE2006000807A PE20070175A1 PE 20070175 A1 PE20070175 A1 PE 20070175A1 PE 2006000807 A PE2006000807 A PE 2006000807A PE 2006000807 A PE2006000807 A PE 2006000807A PE 20070175 A1 PE20070175 A1 PE 20070175A1
Authority
PE
Peru
Prior art keywords
methyl
pirazol
alkyl
dichlorophenyl
chlorophenyl
Prior art date
Application number
PE2006000807A
Other languages
Spanish (es)
Inventor
Francis Barth
Christian Congy
Philippe Pointeau
Murielle Rinaldi-Carmona
Serge Martinez
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20070175A1 publication Critical patent/PE20070175A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS N-[(1,5-DIFENIL-1H-PIRAZOL-3-IL)METIL]SULFONAMIDAS DE FORMULA (I), EN DONDE R1 ES ALQUILO(C1-C12), CARBOCICLO NO AROMATICO(C3-C12), METILO SUSTITUIDO CON CARBOCICLICO NO AROMATICO, FENILO, BENCILO, ENTRE OTROS Y OPCIONALMENTE SUSTITUIDOS; R2 ES H, ALQUILO(C1-C4) O ALQUIL(C1-C4)SULFONILO; R3 ES CIANO, HIDROXILO, ALCOXI(C1-C4), ENTRE OTROS; R4 Y R5 SON INDEPENDIENTEMENTE FENILO OPCIONALMENTE SUSTITUIDOS CON HALOGENO, ALQUILO(C1-C7), ENTRE OTROS. SON PREFERIDOS: N- {[5-(4-CLOROFENIL)-4-CIANO-1-(2,4-DICLOROFENIL)-1H-PIRAZOL-3-IL]METIL}-3-CIANOBENCENOSULFONAMIDA, N- {[5-(4-CLOROFENIL)-4-CIANO-1-(2,4-DICLOROFENIL)-1H-PIRAZOL-3-IL]METIL}-3-TRIFLUOROBENCENOSULFONAMIDA, N- {[5-(4-CLOROFENIL)-4-CIANO-1-(2,4-DICLOROFENIL)-1H-PIRAZOL-3-IL]METIL}-3-TRIFLUOROMETOXIBENCENOSULFONAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DESCRITOS SON ANTAGONISTAS DE LOS RECEPTORES DE CANABINOIDES CB1 Y SON UTILES PARA EL TRATAMIENTO DE MIGRANA, EPILEPSIA, ALZHEIMER, PARKINSON, TEMBLORES, DISTONIAREFERS TO COMPOUNDS N - [(1,5-DIPHENYL-1H-PIRAZOL-3-IL) METHYL] SULPHONAMIDES OF FORMULA (I), WHERE R1 IS ALKYL (C1-C12), NON-AROMATIC CARBOCYCLE (C3-C12) , METHYL SUBSTITUTED WITH NON-AROMATIC CARBOCYCLIC, PHENYL, BENZYL, AMONG OTHERS AND OPTIONALLY SUBSTITUTED; R2 IS H, (C1-C4) ALKYL OR (C1-C4) ALKYL SULFONYL; R3 IS CYANE, HYDROXYL, ALCOXY (C1-C4), AMONG OTHERS; R4 AND R5 ARE INDEPENDENTLY PHENYL, OPTIONALLY SUBSTITUTED WITH HALOGEN, ALKYL (C1-C7), AMONG OTHERS. THE PREFERRED ARE: N- {[5- (4-CHLOROPHENYL) -4-CYAN-1- (2,4-DICHLOROPHENYL) -1H-PIRAZOL-3-IL] METHYL} -3-CYANOBENZENOSULFONAMIDE, N- {[5- (4-CHLOROPHENYL) -4-CYAN-1- (2,4-DICHLOROPHENYL) -1H-PYRAZOLE-3-IL] METHYL} -3-TRIFLUOROBENZENOSULFONAMIDE, N- {[5- (4-CHLOROPHENYL) -4-CYANE -1- (2,4-DICHLOROPHENYL) -1H-PYRAZOLE-3-IL] METHYL} -3-TRIFLUOROMETOXYBENZENOSULFONAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. THE DESCRIBED COMPOUNDS ARE ANTAGONISTS OF CANABINOID CB1 RECEPTORS AND ARE USEFUL FOR THE TREATMENT OF MIGRANA, EPILEPSY, ALZHEIMER, PARKINSON, TREMONS, DISTONIA

PE2006000807A 2005-07-08 2006-07-06 DERIVATIVES OF N - [(1,5-DIPHENYL-1H-PIRAZOL-3-IL) METHYL] SULFONAMIDE AND ITS PREPARATION PE20070175A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0507360A FR2888236B1 (en) 2005-07-08 2005-07-08 N - [(1,5-DIPHENYL-1H-PYRAZOL-3-YL) METHYL] SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

Publications (1)

Publication Number Publication Date
PE20070175A1 true PE20070175A1 (en) 2007-02-23

Family

ID=35872804

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000807A PE20070175A1 (en) 2005-07-08 2006-07-06 DERIVATIVES OF N - [(1,5-DIPHENYL-1H-PIRAZOL-3-IL) METHYL] SULFONAMIDE AND ITS PREPARATION

Country Status (7)

Country Link
AR (1) AR057660A1 (en)
DO (1) DOP2006000163A (en)
FR (1) FR2888236B1 (en)
GT (1) GT200600296A (en)
PE (1) PE20070175A1 (en)
TW (1) TW200800910A (en)
UY (1) UY29657A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7297710B1 (en) 2006-07-12 2007-11-20 Sanofi-Aventis Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide, their preparation and their application in therapeutics
FR2911136B1 (en) * 2007-01-05 2009-02-20 Sanofi Aventis Sa SUBSTITUTED N- (4-CYANO-1H-PYRAZOL-3-YL) METHYLAMINE DERIVATIVES AND THEIR PREPARATION AND THERAPEUTIC USE THEREOF
JP4994295B2 (en) * 2007-04-20 2012-08-08 田辺三菱製薬株式会社 Pharmaceutical composition
CN113200850A (en) * 2021-05-08 2021-08-03 渭南师范学院 Preparation method of alpha-acyloxyketone compound

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2713225B1 (en) * 1993-12-02 1996-03-01 Sanofi Sa Substituted N-piperidino-3-pyrazolecarboxamide.
US7247628B2 (en) * 2002-12-12 2007-07-24 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
FR2856683A1 (en) * 2003-06-25 2004-12-31 Sanofi Synthelabo 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
FR2888236B1 (en) 2007-09-21
FR2888236A1 (en) 2007-01-12
TW200800910A (en) 2008-01-01
GT200600296A (en) 2007-03-14
AR057660A1 (en) 2007-12-12
DOP2006000163A (en) 2007-02-15
UY29657A1 (en) 2007-01-31

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