PE20061010A1 - PHARMACEUTICAL COMPOSITIONS CONTAINING 4-METHYL-2-OXO-2H-1-BENZOPYRAN-7-IL-5-THIO-BETA-D-XYLOPYRANOSIDE - Google Patents

PHARMACEUTICAL COMPOSITIONS CONTAINING 4-METHYL-2-OXO-2H-1-BENZOPYRAN-7-IL-5-THIO-BETA-D-XYLOPYRANOSIDE

Info

Publication number
PE20061010A1
PE20061010A1 PE2006000188A PE2006000188A PE20061010A1 PE 20061010 A1 PE20061010 A1 PE 20061010A1 PE 2006000188 A PE2006000188 A PE 2006000188A PE 2006000188 A PE2006000188 A PE 2006000188A PE 20061010 A1 PE20061010 A1 PE 20061010A1
Authority
PE
Peru
Prior art keywords
xylopyranoside
benzopyran
thio
oxo
beta
Prior art date
Application number
PE2006000188A
Other languages
Spanish (es)
Inventor
Vinod V Tuliani
Michael A Brandley
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20061010A1 publication Critical patent/PE20061010A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONTIENE 4-METIL-2-OXO-2H-1-BENZOPIRAN-7-IL-5-TIO-BETA-D-XILOPIRANOSIDO CARACTERIZADO POR UN NIVEL DE ACTIVIDAD ANTI-IIa EN SITUACION DE EQUILIBRIO, DE AL MENOS 0,25-4 MICROGRAMOS DE UNIDADES DE SULFATO DE DERMATAN POR mL DE PLASMA DURANTE UN LARGO PERIODO DE TIEMPO DESPUES DE LA ADMINISTRACION ORAL Y UN PERFIL DE DISOLUCION EN EL QUE APROXIMADAMENTE EL 75% DE DICHO COMPUESTO SE LIBERA DESPUES DE 8 HORAS. DICHA COMPOSICION FARMACEUTICA ES GASTRORETENTIVO Y COMPRENDE ADEMAS UN POLIMERO HINCHABLE, UN POLIMERO MATRIZ Y UN AGENTE FLOTANTE PROPORCIONANDO MEJOR ABSORCION, EXPOSICION, BIODISPONIBILIDAD Y/O EFICACIA EN EL TRATAMIENTO DE TRASTORNOS TROMBOEMBOLICOSIT REFERS TO A PHARMACEUTICAL COMPOSITION CONTAINING 4-METHYL-2-OXO-2H-1-BENZOPYRAN-7-IL-5-THIO-BETA-D-XYLOPYRANOSIDE CHARACTERIZED BY AN ANTI-IIa ACTIVITY LEVEL IN BALANCED SITUATION, OF AT LEAST 0.25-4 MICROGRAMS OF DERMATAN SULPHATE UNITS PER mL OF PLASMA OVER A LONG PERIOD OF TIME AFTER ORAL ADMINISTRATION AND A DISSOLUTION PROFILE IN WHICH APPROXIMATELY 75% OF SUCH COMPOUND IS RELEASED AFTER 8 . SAID PHARMACEUTICAL COMPOSITION IS GASTRORETENTIVE AND ALSO INCLUDES A INFLATABLE POLYMER, A MATRIX POLYMER AND A FLOATING AGENT PROVIDING BETTER ABSORPTION, EXPOSURE, BIO AVAILABILITY AND / OR EFFECTIVENESS IN THE TREATMENT OF THROMBOEM DISORDERS

PE2006000188A 2005-02-18 2006-02-16 PHARMACEUTICAL COMPOSITIONS CONTAINING 4-METHYL-2-OXO-2H-1-BENZOPYRAN-7-IL-5-THIO-BETA-D-XYLOPYRANOSIDE PE20061010A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65427905P 2005-02-18 2005-02-18
US69612105P 2005-07-01 2005-07-01

Publications (1)

Publication Number Publication Date
PE20061010A1 true PE20061010A1 (en) 2006-11-11

Family

ID=36917125

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000188A PE20061010A1 (en) 2005-02-18 2006-02-16 PHARMACEUTICAL COMPOSITIONS CONTAINING 4-METHYL-2-OXO-2H-1-BENZOPYRAN-7-IL-5-THIO-BETA-D-XYLOPYRANOSIDE

Country Status (4)

Country Link
AR (1) AR054226A1 (en)
PE (1) PE20061010A1 (en)
TW (1) TW200640449A (en)
WO (1) WO2006089215A2 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0421829B1 (en) * 1989-09-22 1994-11-09 Fournier Industrie Et Sante Benzopyranone-beta-D-thioxylosides, method for their preparation and their use
FR2801055B1 (en) * 1999-11-17 2002-02-08 Fournier Ind & Sante BETA-D-5-THIOXYLOSE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE

Also Published As

Publication number Publication date
AR054226A1 (en) 2007-06-13
WO2006089215A2 (en) 2006-08-24
WO2006089215A3 (en) 2006-11-23
TW200640449A (en) 2006-12-01

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