PE20051157A1 - DIHYDROXYPHENYL-ETHYLAMINE DERIVATIVES AS ß2 AGONISTS - Google Patents
DIHYDROXYPHENYL-ETHYLAMINE DERIVATIVES AS ß2 AGONISTSInfo
- Publication number
- PE20051157A1 PE20051157A1 PE2005000320A PE2005000320A PE20051157A1 PE 20051157 A1 PE20051157 A1 PE 20051157A1 PE 2005000320 A PE2005000320 A PE 2005000320A PE 2005000320 A PE2005000320 A PE 2005000320A PE 20051157 A1 PE20051157 A1 PE 20051157A1
- Authority
- PE
- Peru
- Prior art keywords
- dihydroxyphenyl
- methylpropyl
- phenyl
- compounds
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
- C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Abstract
REFERIDA A COMPUESTOS DE FORMULA (1) DONDE (CH2)n-C(=O)Q1 ESTA EN POSICION META O PARA; R1 Y R2 SON CADA UNO H, ALQUILO C1-C4; n ES 0-2; Q1 ES *-NR8-Q2-A, *-NR8-Q3, ENTRE OTROS; Q2 ES ENLACE SENCILLO, ALQUILENO C1-C4 SUSTITUIDO O NO; R8 ES H, ALQUILO C1-C4; Q3 ES ALQUILO C1-C6 SUSTITUIDO O NO; A ES CICLOALQUILO C3-C10, HETEROCICLO DE 5-6 MIEMBROS, QUINOLILO, ENTRE OTROS; * ES EL PUNTO DE UNION AL GRUPO CARBONILO. SON COMPUESTOS PREFERIDOS: N-BENCIL-2-[3-(2-{[2-(3,5-DIHIDROXIFENIL)-2-HIDROXIETIL]AMINO}-2-METILPROPIL)FENIL]ACETAMIDA; 2-[3-(2-{[2-(3,5-DIHIDROXIFENIL)-2-HIDROXIETIL]AMINO}-2-METILPROPIL)FENIL]ACETAMIDA Y 2-(3-{2-[2-(3,5-DIHIDROXIFENIL)-2-HIDROXIETILAMINO]-2-METILPROPIL}FENIL)-1-(4-PIRIDIN-2-ILPIPERAZIN-1-IL)ETANONA; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES PARA TRATAR AFECCIONES INFLAMATORIAS, ALERGICAS Y RESPIRATORIASREFERRED TO COMPOUNDS OF FORMULA (1) WHERE (CH2) n-C (= O) Q1 IS IN A GOAL OR FOR POSITION; R1 AND R2 ARE EACH H, C1-C4 ALKYL; n IS 0-2; Q1 IS * -NR8-Q2-A, * -NR8-Q3, AMONG OTHERS; Q2 IS SINGLE LINK, C1-C4 ALKYLENE REPLACED OR NOT; R8 IS H, C1-C4 ALKYL; Q3 IS C1-C6 ALKYL SUBSTITUTED OR NOT; A IS C3-C10 CYCLOALKYL, 5-6 MEMBER HETERO CYCLE, QUINOLYL, AMONG OTHERS; * IT IS THE POINT OF JOINT TO THE CARBONILO GROUP. PREFERRED COMPOUNDS ARE: N-BENZYL-2- [3- (2 - {[2- (3,5-DIHYDROXYPHENYL) -2-HYDROXYETHYL] AMINO} -2-METHYLPROPYL) PHENYL] ACETAMIDE; 2- [3- (2 - {[2- (3,5-DIHYDROXYPHENYL) -2-HYDROXYETHYL] AMINO} -2-METHYLPROPYL) PHENYL] ACETAMIDE AND 2- (3- {2- [2- (3,5 -DIHYDROXYPHENYL) -2-HYDROXYETHYLAMINE] -2-METHYLPROPYL} PHENYL) -1- (4-PYRIDIN-2-ILPIPERAZIN-1-IL) ETHANONE; AMONG OTHERS. SUCH COMPOUNDS ARE USEFUL TO TREAT INFLAMMATORY, ALLERGIC AND RESPIRATORY CONDITIONS
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04290769 | 2004-03-23 | ||
US59178904P | 2004-07-27 | 2004-07-27 | |
GB0420867A GB0420867D0 (en) | 2004-09-21 | 2004-09-21 | Compounds for the treatment of diseases |
US62550504P | 2004-11-05 | 2004-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20051157A1 true PE20051157A1 (en) | 2006-01-28 |
Family
ID=34961987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000320A PE20051157A1 (en) | 2004-03-23 | 2005-03-21 | DIHYDROXYPHENYL-ETHYLAMINE DERIVATIVES AS ß2 AGONISTS |
Country Status (15)
Country | Link |
---|---|
JP (1) | JP2008174555A (en) |
KR (1) | KR20070026425A (en) |
AP (1) | AP2006003728A0 (en) |
AR (1) | AR048323A1 (en) |
DE (1) | DE602005014624D1 (en) |
EC (1) | ECSP066832A (en) |
IL (1) | IL177531A0 (en) |
MA (1) | MA28482B1 (en) |
NL (1) | NL1028600C2 (en) |
NO (1) | NO20064805L (en) |
PA (1) | PA8627101A1 (en) |
PE (1) | PE20051157A1 (en) |
SV (1) | SV2006002059A (en) |
TW (1) | TW200536521A (en) |
UY (1) | UY28816A1 (en) |
-
2005
- 2005-03-10 AP AP2006003728A patent/AP2006003728A0/en unknown
- 2005-03-10 DE DE602005014624T patent/DE602005014624D1/en not_active Expired - Fee Related
- 2005-03-10 KR KR1020067019542A patent/KR20070026425A/en active IP Right Grant
- 2005-03-18 SV SV2005002059A patent/SV2006002059A/en not_active Application Discontinuation
- 2005-03-21 PE PE2005000320A patent/PE20051157A1/en not_active Application Discontinuation
- 2005-03-21 AR ARP050101097A patent/AR048323A1/en not_active Application Discontinuation
- 2005-03-22 TW TW094108795A patent/TW200536521A/en unknown
- 2005-03-22 NL NL1028600A patent/NL1028600C2/en not_active IP Right Cessation
- 2005-03-22 UY UY28816A patent/UY28816A1/en not_active Application Discontinuation
- 2005-03-23 PA PA20058627101A patent/PA8627101A1/en unknown
-
2006
- 2006-08-16 IL IL177531A patent/IL177531A0/en unknown
- 2006-09-08 EC EC2006006832A patent/ECSP066832A/en unknown
- 2006-09-22 MA MA29337A patent/MA28482B1/en unknown
- 2006-10-23 NO NO20064805A patent/NO20064805L/en not_active Application Discontinuation
-
2008
- 2008-01-16 JP JP2008006758A patent/JP2008174555A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20070026425A (en) | 2007-03-08 |
DE602005014624D1 (en) | 2009-07-09 |
SV2006002059A (en) | 2006-02-15 |
UY28816A1 (en) | 2005-10-31 |
PA8627101A1 (en) | 2005-11-25 |
MA28482B1 (en) | 2007-03-01 |
AR048323A1 (en) | 2006-04-19 |
ECSP066832A (en) | 2006-11-24 |
NO20064805L (en) | 2006-12-01 |
IL177531A0 (en) | 2006-12-10 |
JP2008174555A (en) | 2008-07-31 |
AP2006003728A0 (en) | 2006-10-31 |
NL1028600C2 (en) | 2006-03-06 |
NL1028600A1 (en) | 2005-09-26 |
TW200536521A (en) | 2005-11-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |