PE20041015A1 - 1,2,4-TRIAMINOBENZENE DERIVATIVES AS POTASSIUM CHANNEL OPENERS - Google Patents

1,2,4-TRIAMINOBENZENE DERIVATIVES AS POTASSIUM CHANNEL OPENERS

Info

Publication number
PE20041015A1
PE20041015A1 PE2004000037A PE2004000037A PE20041015A1 PE 20041015 A1 PE20041015 A1 PE 20041015A1 PE 2004000037 A PE2004000037 A PE 2004000037A PE 2004000037 A PE2004000037 A PE 2004000037A PE 20041015 A1 PE20041015 A1 PE 20041015A1
Authority
PE
Peru
Prior art keywords
ilo
amino
cicloalqu
alqu
carbamic
Prior art date
Application number
PE2004000037A
Other languages
Spanish (es)
Inventor
Mario Rottlander
Andreas Ritzen
Christian Wenzel Thornoee
Morten Bang Noergaard
Nikolay Khanzhin
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35295526&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20041015(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of PE20041015A1 publication Critical patent/PE20041015A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE 1,2,4-TRIAMINOBENCENO DE FORMULA I, DONDE R1 ES H, ALQU(EN/IN)ILO(C1-C6), CICLOALQU(EN)ILO(C3-C8), CICLOALQU(EN)IL(C3-C8)-ALQU(EN/IN)ILO(C1-C6), ENTRE OTROS; R2 Y R2´ SON H, ALQU(EN/IN)ILO(C1-C6), CICLOALQU(EN)ILO(C3-C8), ARILO, ENTRE OTROS; R3 ES H, ALQU(EN/IN)ILO(C1-C6), CICLOALQU(EN)ILO(C3-C8), ARILO, CICLOALQU(EN)IL(C3-C8)-ALQU(EN/IN)ILO(C1-C6), ENTRE OTROS; X ES CO O SO2; Z ES O O NR4; R4 ES H, ALQU(EN/IN)IL(C1-C6), CICLOALQU(EN)ILO(C3-C8), ENTRE OTROS; O BIEN R3 Y R4 JUNTO CON EL N AL QUE ESTAN UNIDOS FORMAN UN ANILLO SATURADO O INSATURADO DE 4-8 MIEMBROS QUE CONTIENE 1 A 3 HETEROATOMOS Y ESTAN OPCIONALMENTE SUSTITUIDOS; q ES 0 o 1; Y SON RADICALES DE FORMULA II Y III. SON COMPUESTOS PREFERIDOS: ESTER ETILICO DEL ACIDO {2-AMINO-4-[(5-CLORO-TIOFEN-2-ILMETIL)-METIL-AMINO]-FENIL}-CARBAMICO, ESTER ETILICO DEL ACIDO {2-AMINO-4-[(5-CLORO-TIOFEN-2-ILMETIL)-METIL-AMINO]-FENIL}-CARBAMICO, ESTER ETILICO DEL ACIDO {2-AMINO-4-[(5-METIL-TIOFEN-2-ILMETIL)-METIL-AMINO]-FENIL}-CARBAMICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE. ESTOS COMPUESTOS SON ABRIDORES DE CANALES DE POTASIO DE LA FAMILIA DE KCNQ Y ESPECIALMENTE LA SUB-FAMILIA KCNQ2 Y SON UTILES PARA LA PREVENCION, TRATAMIENTO Y/O INHIBICION DE UNA VARIEDAD DE TRASTORNO DEL SISTEMA NERVIOSO CENTRAL COMO ATAQUE POR APOPLEJIA, DOLOR NEUROPATICO, ANSIEDAD, TRANSTORNOS NEURODEGENERATIVOSREFERS TO 1,2,4-TRIAMINOBENZENE DERIVATIVES OF FORMULA I, WHERE R1 IS H, ALQU (EN / IN) ILO (C1-C6), CICLOALQU (EN) ILO (C3-C8), CICLOALQU (EN) IL (C3-C8) -ALK (EN / IN) ILO (C1-C6), AMONG OTHERS; R2 AND R2´ ARE H, ALQU (EN / IN) ILO (C1-C6), CICLOALQU (EN) ILO (C3-C8), ARYL, AMONG OTHERS; R3 ES H, ALQU (EN / IN) ILO (C1-C6), CICLOALQU (EN) ILO (C3-C8), ARYL, CICLOALQU (EN) IL (C3-C8) -ALQU (EN / IN) ILO (C1 -C6), AMONG OTHERS; X IS CO OR SO2; Z IS O O NR4; R4 IS H, ALK (EN / IN) IL (C1-C6), CYCLOALK (EN) ILO (C3-C8), AMONG OTHERS; OR R3 AND R4 TOGETHER WITH THE N TO WHICH THEY ARE UNITED FORM A SATURATED OR INSATURATED RING OF 4-8 MEMBERS THAT CONTAINS 1 TO 3 HETEROATOMS AND ARE OPTIONALLY REPLACED; q IS 0 or 1; AND THEY ARE FORMULA II AND III RADICALS. PREFERRED COMPOUNDS ARE: ETHYL ACID ESTER {2-AMINO-4 - [(5-CHLORO-THIOPHEN-2-ILMETHYL) -MEthyl-AMINO] -PHENYL} -CARBAMIC, ETHYL ACID ESTER OF {2-AMINO-4- [ (5-CHLORO-THIOFEN-2-ILMETHYL) -MEthyl-AMINO] -PHENYL} -CARBAMIC, ETHYL ACID ESTER {2-AMINO-4 - [(5-METHYL-THIOFEN-2-ILMETIL) -METIL-AMINO] -PHENIL} -CARBAMIC, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION THAT CONTAINS IT. THESE COMPOUNDS ARE OPENERS OF POTASSIUM CHANNELS OF THE KCNQ FAMILY AND ESPECIALLY THE KCNQ2 SUB-FAMILY AND ARE USEFUL FOR THE PREVENTION, TREATMENT AND / OR INHIBITION OF A VARIETY OF DISORDER OF THE KCNQ FAMILY, SUCH AS CENTRAL NERVOUS AXIAL AOPLE AXIAL AXIS , NEURODEGENERATIVE DISORDERS

PE2004000037A 2002-12-27 2004-01-05 1,2,4-TRIAMINOBENZENE DERIVATIVES AS POTASSIUM CHANNEL OPENERS PE20041015A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200202012 2002-12-27

Publications (1)

Publication Number Publication Date
PE20041015A1 true PE20041015A1 (en) 2005-01-08

Family

ID=35295526

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000037A PE20041015A1 (en) 2002-12-27 2004-01-05 1,2,4-TRIAMINOBENZENE DERIVATIVES AS POTASSIUM CHANNEL OPENERS

Country Status (17)

Country Link
KR (1) KR20050089862A (en)
CN (1) CN100448867C (en)
AR (1) AR042656A1 (en)
BR (1) BR0317748A (en)
CL (1) CL2003002748A1 (en)
EA (1) EA008589B1 (en)
HK (1) HK1088317A1 (en)
IS (1) IS2649B (en)
MY (1) MY139844A (en)
NO (1) NO20053612L (en)
PE (1) PE20041015A1 (en)
PL (1) PL377221A1 (en)
SI (1) SI1578740T1 (en)
TW (1) TWI325414B (en)
UA (1) UA79666C2 (en)
UY (1) UY28151A1 (en)
ZA (1) ZA200504565B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4200259A1 (en) * 1992-01-08 1993-07-15 Asta Medica Ag NEW 1,2,4-TRIAMINOBENZOL DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
DE19539861A1 (en) * 1995-10-26 1997-04-30 Asta Medica Ag Use of 4-amino-4- (4-fluorobenzylamino) -1-ethoxy-carbonylaminobenzen for the prophylaxis and treatment of the consequences of acute and chronic cerebral low blood circulation and neurodegenerative diseases
GB9915414D0 (en) * 1999-07-01 1999-09-01 Glaxo Group Ltd Medical use
US6117900A (en) * 1999-09-27 2000-09-12 Asta Medica Aktiengesellschaft Use of retigabine for the treatment of neuropathic pain
US6589986B2 (en) * 2000-12-20 2003-07-08 Wyeth Methods of treating anxiety disorders

Also Published As

Publication number Publication date
AR042656A1 (en) 2005-06-29
NO20053612L (en) 2005-09-23
ZA200504565B (en) 2006-08-30
NO20053612D0 (en) 2005-07-25
BR0317748A (en) 2005-11-22
TW200413280A (en) 2004-08-01
KR20050089862A (en) 2005-09-08
HK1088317A1 (en) 2006-11-03
TWI325414B (en) 2010-06-01
IS7856A (en) 2005-05-23
EA008589B1 (en) 2007-06-29
CN100448867C (en) 2009-01-07
IS2649B (en) 2010-08-15
EA200501053A1 (en) 2005-12-29
MY139844A (en) 2009-11-30
CL2003002748A1 (en) 2005-04-08
PL377221A1 (en) 2006-01-23
UY28151A1 (en) 2004-07-30
CN1732162A (en) 2006-02-08
SI1578740T1 (en) 2007-08-31
UA79666C2 (en) 2007-07-10

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FG Grant, registration
FD Application declared void or lapsed