PE20040832A1 - DERIVATIVES OF INDOLIL PIRAZINONE - Google Patents
DERIVATIVES OF INDOLIL PIRAZINONEInfo
- Publication number
- PE20040832A1 PE20040832A1 PE2003001136A PE2003001136A PE20040832A1 PE 20040832 A1 PE20040832 A1 PE 20040832A1 PE 2003001136 A PE2003001136 A PE 2003001136A PE 2003001136 A PE2003001136 A PE 2003001136A PE 20040832 A1 PE20040832 A1 PE 20040832A1
- Authority
- PE
- Peru
- Prior art keywords
- atoms
- quinoxalinone
- indol
- halo
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE INDOLIL DE FORMULA I, SUS SALES O ESTERES FARMACEUTICAMENTE ACEPTABLES, EN DONDE Ar ES UN ANILLO AROMATICO DE 6 MIEMBROS CON 0, 1 o 2 ATOMOS DE N; R1 Y R2 SON, INDEPENDIENTEMENTE ENTRE SI, H, HALO, CF3, ENTRE OTROS; CON LA CONDICION DE QUE CUANDO Ar CONTIENE 1 o 2 ATOMOS DE N, R1 Y R2 DEBEN SER, CADA UNO, H; Y R1 Y R2 JUNTO CON LOS ATOMOS DE C ADYACENTES A LOS CUALES ESTAN UNIDOS FORMAN UN ANILLO SELECCIONADO DE BENZO, DIOXOLO E IMIDAZO, DONDE DICHO IMIDAZO ESTA OPCIONALMENTE SUSTITUIDO HASTA 2 VECES CON ALQUILO C1-C3; CON LA CONDICION DE QUE R1 Y R2 JUNTO CON LOS ATOMOS DE C ADYACENTES A LOS QUE ESTAN UNIDOS FORMAN UN ANILLO SOLO CUANDO Ar NO CONTIENE ATOMOS DE N; R3 ES H, ALQUILO C1-C4, H, NO2, NH2, ENTRE OTROS; R4 ES H, OH, HALO, CN, ENTRE OTROS; R5 ES H, HALO, CN, ALCOXI C1-C6 o ALQUILO C1-C6; R11 Y R12 SON, INDEPENDIENTEMENTE ENTRE SI, H, F, O Cl; CON LA CONDICION DE QUE CUANDO UNO DE R11 Y R12 ES F o Cl, EL OTRO DEBE SER H. SON COMPUESTOS PREFERIDOS: 3-(1H-INDOL-2-IL)-2(1H)-QUINOXALINONA; 3-(3-NITRO-1H-INDOL-2-IL)-2(1H)-QUINOXALINONA; 3-(3-AMINO-1H-INDOL-2-IL)-2(1H)-QUINOXALINONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN METODO. ESTOS COMPUESTOS SON UTILES PARA TRATAR TRASTORNOS HIPERPROLIFERATIVOSREFERS TO COMPOUNDS DERIVED FROM INDOLIL OF FORMULA I, ITS PHARMACEUTICALLY ACCEPTABLE SALTS OR ESTERS, WHERE Ar IS A 6-MEMBER AROMATIC RING WITH 0, 1, or 2 N ATOMS; R1 AND R2 ARE, INDEPENDENTLY BETWEEN IF, H, HALO, CF3, BETWEEN OTHERS; WITH THE CONDITION THAT WHEN Ar CONTAINS 1 or 2 ATOMS OF N, R1 AND R2 MUST EACH H; AND R1 AND R2 TOGETHER WITH THE ADJACENT C ATOMS TO WHICH THEY ARE UNITED FORM A SELECTED RING OF BENZO, DIOXOLO AND IMIDAZO, WHERE SAID IMIDAZO IS OPTIONALLY SUBSTITUTED UP TO 2 TIMES WITH C1-C3 ALKYL; WITH THE CONDITION THAT R1 AND R2 TOGETHER WITH THE ADJACENT C ATOMS TO WHICH THEY ARE UNITED, MAKE A RING ONLY WHEN Ar DOES NOT CONTAIN N ATOMS; R3 IS H, C1-C4 ALKYL, H, NO2, NH2, AMONG OTHERS; R4 IS H, OH, HALO, CN, AMONG OTHERS; R5 IS H, HALO, CN, C1-C6 ALCOXY or C1-C6 ALKYL; R11 AND R12 ARE, INDEPENDENTLY BETWEEN IF, H, F, OR Cl; WITH THE CONDITION THAT WHEN ONE OF R11 AND R12 IS F or Cl, THE OTHER MUST BE H. THE PREFERRED COMPOUNDS ARE: 3- (1H-INDOL-2-IL) -2 (1H) -QUINOXALINONE; 3- (3-NITRO-1H-INDOL-2-IL) -2 (1H) -QUINOXALINONE; 3- (3-AMINO-1H-INDOL-2-IL) -2 (1H) -QUINOXALINONE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A METHOD. THESE COMPOUNDS ARE USEFUL TO TREAT HYPERPROLIFERATIVE DISORDERS
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42549002P | 2002-11-12 | 2002-11-12 | |
US46091503P | 2003-04-07 | 2003-04-07 | |
US48420203P | 2003-06-30 | 2003-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20040832A1 true PE20040832A1 (en) | 2005-01-27 |
Family
ID=32314888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003001136A PE20040832A1 (en) | 2002-11-12 | 2003-11-11 | DERIVATIVES OF INDOLIL PIRAZINONE |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1565455A1 (en) |
JP (1) | JP2006509840A (en) |
KR (1) | KR20050072824A (en) |
AR (1) | AR043059A1 (en) |
AU (1) | AU2003290744A1 (en) |
BR (1) | BR0316169A (en) |
CA (1) | CA2505819A1 (en) |
EC (1) | ECSP055851A (en) |
HR (1) | HRP20050496A2 (en) |
MA (1) | MA27557A1 (en) |
MX (1) | MXPA05004779A (en) |
NO (1) | NO20052796D0 (en) |
PE (1) | PE20040832A1 (en) |
PL (1) | PL376867A1 (en) |
TW (1) | TW200418834A (en) |
UY (1) | UY28074A1 (en) |
WO (1) | WO2004043950A1 (en) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7767684B2 (en) | 2003-11-13 | 2010-08-03 | Abbott Laboratories | Apoptosis promoters |
US8614318B2 (en) | 2003-11-13 | 2013-12-24 | Abbvie Inc. | Apoptosis promoters |
US7973161B2 (en) | 2003-11-13 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
WO2005049593A2 (en) * | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
NZ546990A (en) | 2003-11-20 | 2010-03-26 | Janssen Pharmaceutica Nv | 7-Phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors |
WO2005054201A1 (en) | 2003-11-20 | 2005-06-16 | Janssen Pharmaceutica N.V. | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
JP2007512331A (en) * | 2003-11-21 | 2007-05-17 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | Indolyl-thieno'3,4-B useful for the treatment of hyperproliferative diseases and diseases associated with angiogenesis! Pyrazin-3-one derivatives |
US7459562B2 (en) * | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
DE602005026391D1 (en) | 2004-06-30 | 2011-03-31 | Janssen Pharmaceutica Nv | CHINAZOLINONE DERIVATIVES AS PARP HEMMER |
EP1771175B1 (en) | 2004-06-30 | 2015-12-23 | Janssen Pharmaceutica NV | Phthalazine derivatives as parp inhibitors |
AU2005259190B2 (en) | 2004-06-30 | 2011-05-12 | Janssen Pharmaceutica N.V. | Quinazolinedione derivatives as PARP inhibitors |
BRPI0517734A (en) | 2004-11-17 | 2008-10-21 | Korea Res Inst Chem Tech | 1 - [(6,7-substituted alkoxyquinoxalinyl) aminocarbonyl] -4- (hetero) arylpiperazine derivatives |
US8624027B2 (en) | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
ES2493466T3 (en) | 2005-05-12 | 2014-09-11 | Abbvie Bahamas Ltd. | Apoptosis promoters |
WO2008016123A1 (en) * | 2006-08-03 | 2008-02-07 | Takeda Pharmaceutical Company Limited | GSK-3β INHIBITOR |
US7897762B2 (en) * | 2006-09-14 | 2011-03-01 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of proliferative diseases |
US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
MX2010010406A (en) | 2008-03-27 | 2010-10-25 | Janssen Pharmaceutica Nv | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors. |
WO2010053757A1 (en) * | 2008-10-29 | 2010-05-14 | Gilead Palo Alto, Inc. | 2 -oxoquinoxalin blockers of the late sodium channel |
US20100113514A1 (en) | 2008-10-30 | 2010-05-06 | Gilead Palo Alto, Inc. | Fused heterocyclic compounds as ion channel modulators |
EP2352725A1 (en) * | 2008-11-07 | 2011-08-10 | Wyeth LLC | Quinoxaline-based lxr modulators |
US20100160322A1 (en) | 2008-12-04 | 2010-06-24 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
US8557983B2 (en) | 2008-12-04 | 2013-10-15 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
RU2715893C2 (en) | 2014-03-26 | 2020-03-04 | Астекс Терапьютикс Лтд | Combination of inhibitor fgfr and inhibitor igf1r |
JO3512B1 (en) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | Quinoxaline derivatives useful as fgfr kinase modulators |
HUE053654T2 (en) | 2014-03-26 | 2021-07-28 | Astex Therapeutics Ltd | Combinations of fgfr- and cmet-inhibitors for the treatment of cancer |
JP6510556B2 (en) * | 2014-04-18 | 2019-05-08 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | Quinoxaline compounds and uses thereof |
EP3247705B1 (en) | 2015-01-20 | 2019-11-20 | Millennium Pharmaceuticals, Inc. | Quinazoline and quinoline compounds and uses thereof as nampt inhibitors |
JOP20200201A1 (en) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | Pharmaceutical compositions comprising n-(3,5-dimethoxyphenyl)-n'-(1-methylethyl)-n-[3-(1-methyl-1h-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
EP3353164B1 (en) | 2015-09-23 | 2021-11-03 | Janssen Pharmaceutica, N.V. | Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer |
SI3353177T1 (en) | 2015-09-23 | 2020-08-31 | Janssen Pharmaceutica Nv | Tricyclic heterocycles for the treatment of cancer |
WO2023050007A1 (en) * | 2021-09-29 | 2023-04-06 | Repare Therapeutics Inc. | N-(5-substituted-[(1,3,4-thiadiazolyl) or (thiazolyl)])(substituted)carboxamide compounds and use thereof for inhibiting human polymerase theta |
WO2024069592A1 (en) * | 2022-09-29 | 2024-04-04 | Repare Therapeutics Inc. | N-(5-substituted-[(l,3,4-thiadiazolyl) or (l,3-thiazolyl)](substituted)carboxamide compounds, pharmaceutical compositions, and methods of preparing the amide compounds and of their use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW472045B (en) * | 1996-09-25 | 2002-01-11 | Astra Ab | Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation |
AU1918299A (en) * | 1998-02-23 | 1999-09-06 | Warner-Lambert Company | Substituted quinoxaline derivatives as interleukin-8 receptor antagonists |
-
2003
- 2003-11-05 AR ARP030104059A patent/AR043059A1/en unknown
- 2003-11-10 KR KR1020057008396A patent/KR20050072824A/en not_active Application Discontinuation
- 2003-11-10 MX MXPA05004779A patent/MXPA05004779A/en not_active Application Discontinuation
- 2003-11-10 JP JP2005507146A patent/JP2006509840A/en active Pending
- 2003-11-10 CA CA002505819A patent/CA2505819A1/en not_active Abandoned
- 2003-11-10 BR BR0316169-2A patent/BR0316169A/en not_active Application Discontinuation
- 2003-11-10 PL PL376867A patent/PL376867A1/en unknown
- 2003-11-10 EP EP03783328A patent/EP1565455A1/en not_active Withdrawn
- 2003-11-10 AU AU2003290744A patent/AU2003290744A1/en not_active Abandoned
- 2003-11-10 WO PCT/US2003/036003 patent/WO2004043950A1/en active Application Filing
- 2003-11-11 TW TW092131443A patent/TW200418834A/en unknown
- 2003-11-11 UY UY28074A patent/UY28074A1/en not_active Application Discontinuation
- 2003-11-11 PE PE2003001136A patent/PE20040832A1/en not_active Application Discontinuation
-
2005
- 2005-06-02 HR HR20050496A patent/HRP20050496A2/en not_active Application Discontinuation
- 2005-06-09 NO NO20052796A patent/NO20052796D0/en not_active Application Discontinuation
- 2005-06-09 MA MA28322A patent/MA27557A1/en unknown
- 2005-06-10 EC EC2005005851A patent/ECSP055851A/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20050072824A (en) | 2005-07-12 |
AR043059A1 (en) | 2005-07-13 |
NO20052796L (en) | 2005-06-09 |
CA2505819A1 (en) | 2004-05-27 |
UY28074A1 (en) | 2004-05-31 |
NO20052796D0 (en) | 2005-06-09 |
MXPA05004779A (en) | 2005-07-22 |
JP2006509840A (en) | 2006-03-23 |
EP1565455A1 (en) | 2005-08-24 |
AU2003290744A1 (en) | 2004-06-03 |
HRP20050496A2 (en) | 2006-06-30 |
MA27557A1 (en) | 2005-10-03 |
BR0316169A (en) | 2005-09-27 |
PL376867A1 (en) | 2006-01-09 |
TW200418834A (en) | 2004-10-01 |
WO2004043950A1 (en) | 2004-05-27 |
ECSP055851A (en) | 2005-09-20 |
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