PE20030411A1 - 8ß-SUBSTITUTED DERIVATIVES OF 11ß-FENYL AND 11ß-HEXIL-ESTRA-1,3,5 (10) -TRIENE THAT HAVE AFFINITY FOR ESTROGEN RECEPTORS - Google Patents
8ß-SUBSTITUTED DERIVATIVES OF 11ß-FENYL AND 11ß-HEXIL-ESTRA-1,3,5 (10) -TRIENE THAT HAVE AFFINITY FOR ESTROGEN RECEPTORSInfo
- Publication number
- PE20030411A1 PE20030411A1 PE2001001011A PE2001001011A PE20030411A1 PE 20030411 A1 PE20030411 A1 PE 20030411A1 PE 2001001011 A PE2001001011 A PE 2001001011A PE 2001001011 A PE2001001011 A PE 2001001011A PE 20030411 A1 PE20030411 A1 PE 20030411A1
- Authority
- PE
- Peru
- Prior art keywords
- estra
- r19so2o
- ocor22
- halogen
- alkyl
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS 8ß-SUSTITUIDOS DE 11ß-FENIL Y 11ß-HEXIL-ESTRA-1,3,5(10)-TRIENO DE FORMULA I DONDE R2 ES H, HALOGENO, R18, OR18; R18 ES H, ALQUILO, ACILO, TRIFLUOROMETILO, R19SO2O, R19 ES R20R21N; R20 Y R21 SON H, ALQUILO C1-C5, COR22; R22 ES CICLOALQUILO C3-C7, ARILO, HETEROARILO, ARALQUILO, POLIMETILENIMINO, MORFOLINO; R3 ES R18O, R19SO2, OCOR22; R6 Y R6' SON H O UNO FORMA CON R7 UN ENLACE; R7 Y R7' SON H; R8 ES ALQUILO, ALQUENILO, ETINILO C1-C5, PROP-1-INILO; R14 ES H, FORMA UN ENLACE CON R15; R15 ES H, FORMA UN ENLACE CON R14 O R16; R15' Y R16' SON H, HALOGENO, R18O, R19SO2O, OCOR22; R17' Y R17 SON H, H Y HALO, H Y BENCILOXI, H Y R19SO2O, R18-O, OCOR22, JUNTOS SON =CR23R24; R23 Y R24 SON H, HALOGENO, O. SON COMPUESTOS PREFERIDOS 8ß-METIL-11ß-PENTIL-1,3,5(10)-TRIEN-3,17ß-DIOL, 11ß-PENTIL-8ß-VINIL-ESTRA-1,3,5(10)-TRIEN-3,17ß-DIOL, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS ANTAGONISTAS DE GnRH, ANTAGONISTAS DE RECEPTORES DE PROGESTERONA, MESOPROGESTINAS, GESTAGENOS, GESTAGENOS SELECTIVOS DE TEJIDOS. LOS COMPUESTOS TIENEN AFINIDAD POR RECEPTORES DE ESTROGENO, INHIBEN LA GENERACION DEL FOLICULO, OVULACION PUDIENDO SER UTILES COMO ANTICONCEPTIVOS, O PARA CONTRACEPTIVOS EN EL HOMBRE, Y PARA EL TRATAMIENTO DE ENFERMEDADES OVARICAS PROLIFERATIVAS, BENIGNAS, MALIGNAS, CARCINOMAS OVARICOS, TUMORES CELULARES DE GRANULOSAREFERS TO 8ß-SUBSTITUTED DERIVATIVES OF 11ß-FENYL AND 11ß-HEXIL-ESTRA-1,3,5 (10) -TRIENE OF FORMULA I WHERE R2 IS H, HALOGEN, R18, OR18; R18 IS H, ALKYL, ACILO, TRIFLUOROMETHYL, R19SO2O, R19 IS R20R21N; R20 AND R21 ARE H, C1-C5 ALKYL, COR22; R22 IS C3-C7 CYCLOALKYL, ARYL, HETEROARYL, ARALKYL, POLYMETHYLENIMINE, MORPHOLINE; R3 IS R18O, R19SO2, OCOR22; R6 AND R6 'ARE H O ONE FORM WITH R7 A LINK; R7 AND R7 'ARE H; R8 IS ALKYL, ALKENYL, C1-C5 ETHINYL, PROP-1-INYL; R14 IS H, FORMS A LINK WITH R15; R15 IS H, FORMS A LINK WITH R14 OR R16; R15 'AND R16' ARE H, HALOGEN, R18O, R19SO2O, OCOR22; R17 'AND R17 ARE H, H AND HALO, H AND BENZYLOXY, H AND R19SO2O, R18-O, OCOR22, TOGETHER ARE = CR23R24; R23 AND R24 ARE H, HALOGEN, O. THE PREFERRED COMPOUNDS 8ß-METHYL-11ß-PENTIL-1,3,5 (10) -TRIEN-3,17ß-DIOL, 11ß-PENTIL-8ß-VINYL-ESTRA-1, 3,5 (10) -TRIEN-3,17ß-DIOL, AMONG OTHERS. IT ALSO REFERS TO A COMPOSITION THAT ALSO INCLUDES GnRH ANTAGONISTS, PROGESTERONE RECEPTOR ANTAGONISTS, MESOPROGESTINES, GESTAGENS, TISSUE SELECTIVE GESTAGENS. THE COMPOUNDS HAVE AFFINITY FOR ESTROGEN RECEPTORS, INHIBIT THE GENERATION OF THE FOLLICLE, OVULATION, MAY BE USEFUL AS CONTRACEPTIVES, OR FOR CONTRACEPTIVES IN MAN, AND FOR THE TREATMENT OF OVARIC, PROLIFERATIVE, CARUMINARY, OR OVARICAL, CULIFERATIVE, OVARIC, TUBALOMAR, OR MALIFERATIVE DISEASES.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PE2001001011A PE20030411A1 (en) | 2001-10-12 | 2001-10-12 | 8ß-SUBSTITUTED DERIVATIVES OF 11ß-FENYL AND 11ß-HEXIL-ESTRA-1,3,5 (10) -TRIENE THAT HAVE AFFINITY FOR ESTROGEN RECEPTORS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PE2001001011A PE20030411A1 (en) | 2001-10-12 | 2001-10-12 | 8ß-SUBSTITUTED DERIVATIVES OF 11ß-FENYL AND 11ß-HEXIL-ESTRA-1,3,5 (10) -TRIENE THAT HAVE AFFINITY FOR ESTROGEN RECEPTORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030411A1 true PE20030411A1 (en) | 2003-05-21 |
Family
ID=43602610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001001011A PE20030411A1 (en) | 2001-10-12 | 2001-10-12 | 8ß-SUBSTITUTED DERIVATIVES OF 11ß-FENYL AND 11ß-HEXIL-ESTRA-1,3,5 (10) -TRIENE THAT HAVE AFFINITY FOR ESTROGEN RECEPTORS |
Country Status (1)
| Country | Link |
|---|---|
| PE (1) | PE20030411A1 (en) |
-
2001
- 2001-10-12 PE PE2001001011A patent/PE20030411A1/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |