PE20030225A1 - ARYLIC COMPOUNDS SUBSTITUTED WITH QUINUCLIDINES FOR THE TREATMENT OF DISEASES - Google Patents

ARYLIC COMPOUNDS SUBSTITUTED WITH QUINUCLIDINES FOR THE TREATMENT OF DISEASES

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Publication number
PE20030225A1
PE20030225A1 PE2001000836A PE2001000836A PE20030225A1 PE 20030225 A1 PE20030225 A1 PE 20030225A1 PE 2001000836 A PE2001000836 A PE 2001000836A PE 2001000836 A PE2001000836 A PE 2001000836A PE 20030225 A1 PE20030225 A1 PE 20030225A1
Authority
PE
Peru
Prior art keywords
alkyl
quinuclidines
treatment
cycloalkyl
oct
Prior art date
Application number
PE2001000836A
Other languages
Spanish (es)
Inventor
Jason K Myers
Jr Vincent E Groppi
David W Piotrowski
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20030225A1 publication Critical patent/PE20030225A1/en

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Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS ARILICOS SUSTITUIDOS CON QUINUCLIDINAS DE FORMULA I DONDE X ES O, S; R1 ES H, ALQUILO, CICLOALQUILO, ALQUILO HALOGENADO, ARILO; R2 ES H, ALQUILO, ALQUILO HALOGENADO, CICLOALQUILO, BENCILO, ENTRE OTROS; R3 ES H, ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO, ENTRE OTROS; R4 ES -0-R5, -S-R5, -S(O)-R5, ENTRE OTROS; R5 ES ARILO, R7 O R9; R7 ES UN GRUPO HETEROAROMATICO MONOCICLICO DE 5 MIEMBROS CON 1 A 3 HETEROATOMOS; R9 ES UN HETEROAROMATICO MONOCICLICO DE 6 MIEMBROS CON 1 A 3 HETEROATOMOS. SON COMPUESTOS PREFERIDOS N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-4-[4-(HIDROXIFENOXI)BENZAMIDA, N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-4-[4-(ACETAMIDOFENOXI)BENZAMIDA, N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-4-FENOXIBENZAMIDA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS TIENEN MAYOR ACTIVIDAD SOBRE LOS RECEPTORES DE LA ACETILCOLINA O7 NICOTINICOS Y SON UTILES PARA EL TRATAMIENTO DE ESCLEROSIS LATERAL AMIOTROFICA, LESIONES CEREBRALESREFERS TO ARYLIC COMPOUNDS SUBSTITUTED WITH QUINUCLIDINES OF FORMULA I WHERE X IS O, S; R1 IS H, ALKYL, CYCLOALKYL, HALOGENATED ALKYL, ARYL; R2 IS H, ALKYL, HALOGENATED ALKYL, CYCLOALKYL, BENZYL, AMONG OTHERS; R3 IS H, ALKYL, ALKENYL, ALKINYL, CYCLOALKYL, AMONG OTHERS; R4 IS -0-R5, -S-R5, -S (O) -R5, AMONG OTHERS; R5 IS ARYL, R7 OR R9; R7 IS A MONOCYCLIC HETEROAROMATIC GROUP OF 5 MEMBERS WITH 1 TO 3 HETEROATOMES; R9 IS A 6-MEMBER MONOCYCLIC HETEROAROMATIC WITH 1 TO 3 HETEROATOMS. PREFERRED COMPOUNDS ARE N - [(3R) -1-AZABICYCLE [2.2.2] OCT-3-IL] -4- [4- (HYDROXYPHENOXY) BENZAMIDE, N - [(3R) -1-AZABICYCLE [2.2.2] OCT-3-IL] -4- [4- (ACETAMIDOPHENOXY) BENZAMIDE, N - [(3R) -1-AZABICYCLO [2.2.2] OCT-3-IL] -4-PHENOXYBENZAMIDE, AMONG OTHERS. THE MENTIONED COMPOUNDS HAVE GREATER ACTIVITY ON ACETYLCHOLINE O7 NICOTINES RECEPTORS AND ARE USEFUL FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS, BRAIN LESIONS

PE2001000836A 2000-08-18 2001-08-21 ARYLIC COMPOUNDS SUBSTITUTED WITH QUINUCLIDINES FOR THE TREATMENT OF DISEASES PE20030225A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22616400P 2000-08-18 2000-08-18
US28497101P 2001-04-19 2001-04-19

Publications (1)

Publication Number Publication Date
PE20030225A1 true PE20030225A1 (en) 2003-03-14

Family

ID=43602600

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000836A PE20030225A1 (en) 2000-08-18 2001-08-21 ARYLIC COMPOUNDS SUBSTITUTED WITH QUINUCLIDINES FOR THE TREATMENT OF DISEASES

Country Status (1)

Country Link
PE (1) PE20030225A1 (en)

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