PE20030225A1 - ARYLIC COMPOUNDS SUBSTITUTED WITH QUINUCLIDINES FOR THE TREATMENT OF DISEASES - Google Patents
ARYLIC COMPOUNDS SUBSTITUTED WITH QUINUCLIDINES FOR THE TREATMENT OF DISEASESInfo
- Publication number
- PE20030225A1 PE20030225A1 PE2001000836A PE2001000836A PE20030225A1 PE 20030225 A1 PE20030225 A1 PE 20030225A1 PE 2001000836 A PE2001000836 A PE 2001000836A PE 2001000836 A PE2001000836 A PE 2001000836A PE 20030225 A1 PE20030225 A1 PE 20030225A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- quinuclidines
- treatment
- cycloalkyl
- oct
- Prior art date
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS ARILICOS SUSTITUIDOS CON QUINUCLIDINAS DE FORMULA I DONDE X ES O, S; R1 ES H, ALQUILO, CICLOALQUILO, ALQUILO HALOGENADO, ARILO; R2 ES H, ALQUILO, ALQUILO HALOGENADO, CICLOALQUILO, BENCILO, ENTRE OTROS; R3 ES H, ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO, ENTRE OTROS; R4 ES -0-R5, -S-R5, -S(O)-R5, ENTRE OTROS; R5 ES ARILO, R7 O R9; R7 ES UN GRUPO HETEROAROMATICO MONOCICLICO DE 5 MIEMBROS CON 1 A 3 HETEROATOMOS; R9 ES UN HETEROAROMATICO MONOCICLICO DE 6 MIEMBROS CON 1 A 3 HETEROATOMOS. SON COMPUESTOS PREFERIDOS N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-4-[4-(HIDROXIFENOXI)BENZAMIDA, N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-4-[4-(ACETAMIDOFENOXI)BENZAMIDA, N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-4-FENOXIBENZAMIDA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS TIENEN MAYOR ACTIVIDAD SOBRE LOS RECEPTORES DE LA ACETILCOLINA O7 NICOTINICOS Y SON UTILES PARA EL TRATAMIENTO DE ESCLEROSIS LATERAL AMIOTROFICA, LESIONES CEREBRALESREFERS TO ARYLIC COMPOUNDS SUBSTITUTED WITH QUINUCLIDINES OF FORMULA I WHERE X IS O, S; R1 IS H, ALKYL, CYCLOALKYL, HALOGENATED ALKYL, ARYL; R2 IS H, ALKYL, HALOGENATED ALKYL, CYCLOALKYL, BENZYL, AMONG OTHERS; R3 IS H, ALKYL, ALKENYL, ALKINYL, CYCLOALKYL, AMONG OTHERS; R4 IS -0-R5, -S-R5, -S (O) -R5, AMONG OTHERS; R5 IS ARYL, R7 OR R9; R7 IS A MONOCYCLIC HETEROAROMATIC GROUP OF 5 MEMBERS WITH 1 TO 3 HETEROATOMES; R9 IS A 6-MEMBER MONOCYCLIC HETEROAROMATIC WITH 1 TO 3 HETEROATOMS. PREFERRED COMPOUNDS ARE N - [(3R) -1-AZABICYCLE [2.2.2] OCT-3-IL] -4- [4- (HYDROXYPHENOXY) BENZAMIDE, N - [(3R) -1-AZABICYCLE [2.2.2] OCT-3-IL] -4- [4- (ACETAMIDOPHENOXY) BENZAMIDE, N - [(3R) -1-AZABICYCLO [2.2.2] OCT-3-IL] -4-PHENOXYBENZAMIDE, AMONG OTHERS. THE MENTIONED COMPOUNDS HAVE GREATER ACTIVITY ON ACETYLCHOLINE O7 NICOTINES RECEPTORS AND ARE USEFUL FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS, BRAIN LESIONS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22616400P | 2000-08-18 | 2000-08-18 | |
US28497101P | 2001-04-19 | 2001-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030225A1 true PE20030225A1 (en) | 2003-03-14 |
Family
ID=43602600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000836A PE20030225A1 (en) | 2000-08-18 | 2001-08-21 | ARYLIC COMPOUNDS SUBSTITUTED WITH QUINUCLIDINES FOR THE TREATMENT OF DISEASES |
Country Status (1)
Country | Link |
---|---|
PE (1) | PE20030225A1 (en) |
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2001
- 2001-08-21 PE PE2001000836A patent/PE20030225A1/en not_active Application Discontinuation
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FA | Abandonment or withdrawal |