PE20011105A1 - CARBOXYL ACID DERIVATIVES AS ANTAGONISTS OF THE IP RECEPTOR - Google Patents

CARBOXYL ACID DERIVATIVES AS ANTAGONISTS OF THE IP RECEPTOR

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Publication number
PE20011105A1
PE20011105A1 PE2001000236A PE2001000236A PE20011105A1 PE 20011105 A1 PE20011105 A1 PE 20011105A1 PE 2001000236 A PE2001000236 A PE 2001000236A PE 2001000236 A PE2001000236 A PE 2001000236A PE 20011105 A1 PE20011105 A1 PE 20011105A1
Authority
PE
Peru
Prior art keywords
propionic
acid
biphenyl
antagonists
receptor
Prior art date
Application number
PE2001000236A
Other languages
Spanish (es)
Inventor
Richard Leo Cournoyer
Paul Francis Keitz
Counde O'yang
Alexander Victor Muehldorf
Lowrie
Dennis Mitsugu Yasuda
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20011105A1 publication Critical patent/PE20011105A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A DERIVADOS DEL ACIDO CARBOXILICO DE FORMULA I DONDE R1, R2 Y R3 SON ARILO, HETEROARILO, ALQUILO, HALO, HALOALQUILO, TRIFLUOROMETILO, HIDROXILO, HIDROXIALQUILO, ALCOXILO, ENTRE OTROS; R4 ES COOH, TETRAZOLILO; A ES -O(CH2)p, -S(CH2)p-, NR'(CH2)p-, -(CH2)pO-, -O(CH2)pO, ENTRE OTROS; R' ES H, ALQUILO; B ES -(CH2)q-, -CH2O-, -CH2OCH2-, -CH2N-; m, p Y q SON 1-3; n Y r SON 0-3. SON COMPUESTOS PREFERIDOS ACIDO 2-(BIFENIL-4-ILMETOXICARBONILAMINO)-3-FENIL-PROPIONICO, ACIDO 2-(BIFENIL-4-ILMETOXICARBONILAMINO) -3-(3-INDOLIL-PROPIONICO, ACIDO -(3-BENCENOSULFONILAMINO-FENIL)-2-(BIFENIL-4-ILMETOXICARBONILAMINO) -PROPIONICO, ACIDO (R)-2-(4-FENOXIMETIL-BENCILOXICARBONILAMINO)-3-FENIL-PROPIONICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS DE FORMULA I SON ANTAGONISTAS DEL RECEPTOR DE LA PROSTAGLANDINA IP ( I2 o PROSTACICLINA PGI2 ) Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES ASOCIADOS AL TRACTO URINARIO, RESPIRATORIOS, EDEMAS, ENFERMEDADES VASCULARESREFERS TO DERIVATIVES OF THE CARBOXYL ACID OF FORMULA I WHERE R1, R2 AND R3 ARE ARYL, HETEROARYL, ALKYL, HALO, HALOALKYL, TRIFLUOROMETHYL, HYDROXYL, HYDROXYALKYL, ALCOXYL, BETWEEN; R4 IS COOH, TETRAZOLYL; A IS -O (CH2) p, -S (CH2) p-, NR '(CH2) p-, - (CH2) pO-, -O (CH2) pO, AMONG OTHERS; R 'IS H, ALKYL; B IS - (CH2) q-, -CH2O-, -CH2OCH2-, -CH2N-; m, p AND q ARE 1-3; n AND r ARE 0-3. THE PREFERRED COMPOUNDS ARE 2- (BIPHENYL-4-ILMETOXICARBONYLAMINE) -3-PHENYL-PROPIONIC ACID, 2- (BIPHENYL-4-ILMETOXYCARBONYLAMINE) -3- (3-INDOLYL-PROPIONIC, ACID - (3-BENENYL) 2- (BIPHENYL-4-ILMETOXICARBONYLAMINO) -PROPIONIC, ACID (R) -2- (4-PHENOXIMETHYL-BENZYLOXYCARBONYLAMINE) -3-PHENYL-PROPIONIC, AMONG OTHERS, ALSO REFERRED TO A COMPOSITION AND A PHARMACEUTICAL PREPARATION. THE COMPOUNDS OF FORMULA I ARE ANTAGONISTS OF THE IP PROSTAGLANDIN RECEPTOR (I2 or PROSTACYCLIN PGI2) AND ARE USEFUL FOR THE TREATMENT OF DISEASES ASSOCIATED WITH THE URINARY TRACT, RESPIRATORY, EDEMAS, VASCULAR DISEASES

PE2001000236A 2000-03-16 2001-03-12 CARBOXYL ACID DERIVATIVES AS ANTAGONISTS OF THE IP RECEPTOR PE20011105A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19012900P 2000-03-16 2000-03-16

Publications (1)

Publication Number Publication Date
PE20011105A1 true PE20011105A1 (en) 2001-10-29

Family

ID=32592622

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000236A PE20011105A1 (en) 2000-03-16 2001-03-12 CARBOXYL ACID DERIVATIVES AS ANTAGONISTS OF THE IP RECEPTOR

Country Status (2)

Country Link
PE (1) PE20011105A1 (en)
ZA (1) ZA200206860B (en)

Also Published As

Publication number Publication date
ZA200206860B (en) 2003-11-27

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