PE20001057A1 - NEW BIS-BENZIMIDAZOLES - Google Patents

NEW BIS-BENZIMIDAZOLES

Info

Publication number
PE20001057A1
PE20001057A1 PE1999000986A PE00098699A PE20001057A1 PE 20001057 A1 PE20001057 A1 PE 20001057A1 PE 1999000986 A PE1999000986 A PE 1999000986A PE 00098699 A PE00098699 A PE 00098699A PE 20001057 A1 PE20001057 A1 PE 20001057A1
Authority
PE
Peru
Prior art keywords
alkyl
halogen
cyane
nitro
aryl
Prior art date
Application number
PE1999000986A
Other languages
Spanish (es)
Inventor
Joachin Mittendorf
Makiko Hiraoka
Muneto Mogi
Toshiki Murata
Mitsuyuki Shimada
Nagahiro Yoshida
Sachiko Sakakibara
Toshiya Moriwaki
Hiroshi Kadono
Siegfried Raddatz
Karl-Heinz Schlemmer
Rolf Henning
Original Assignee
Bayer Yakuhin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Yakuhin Ltd filed Critical Bayer Yakuhin Ltd
Publication of PE20001057A1 publication Critical patent/PE20001057A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS BIS-BENZIMIDAZOLES DE FORMULA I DONDE R1, R2, R3 Y R4 SON H, OH o HALOGENO; R5 Y R8 SON H, ALQUILO C1-C4; R6 Y R7 SON H, ALQUILO C1-C6, OH, HALOGENO, ALCOXI C1-C6; R9, R10 Y R11 SON H, HALOGENO, NITRO, CIANO O TRIFLUORMETILO; A ES UN GRUPO a, b, c, d; UN N-HETEROCICLO NO AROMATICO DE 5-7 MIEMBROS OPCIONALMENTE CONTIENE O, NR14, CHR15, NR19R20; R12 Y R13 SON H, HALOGENO, NITRO, CIANO, ALQUILO C1-C6, ALCOXI C1-C6, OH; R14 Y R15 SON H, CICLOALQUILO C3-C8, ALQUILO C1-C4, ARILO C6-C10, HETEROCICLO DE 5-6 MIEMBROS, OPCIONALEMENTE SUSTITUIDO CON HALOGENO, CIANO, OH, NR16R17, ENTRE OTROS; O R14 ES -SO2-R18; R16 Y R17 SON H, ALQUILO C1-C4, ACILO C1-C4, SO2-CF3 O JUNTO CON N FORMAN UN HETEROCICLO AROMATICO DE 5-7 MIEMBROS; R18 ES ARILO C6-C10, ALQUILO C1-C4; R19 ES H, ALQUILO C1-C4; R20 ES D-E-R21; D ES ALQUILO C1-C6; E ES UN ENLACE, O; R21 ES ARILO C6-C10, HETEROCICLO DE 5-6 MIEMBROS OPCIONALMENTE SUSTITUIDO CON NITRO, CIANO, HALOGENO, TETRAZOLILO, NR22R23; R22 Y R23 SON H, ACILO C1-C6, ALQUILO C1-C6; R22 ES H; Y R23 ES SO2-CF3. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO DE FORMULA I INHIBE A LA TRIPTASA POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE ASMA, RINITIS ALERGICAREFERS TO BIS-BENZIMIDAZOLES COMPOUNDS OF FORMULA I WHERE R1, R2, R3 AND R4 ARE H, OH or HALOGEN; R5 AND R8 ARE H, C1-C4 ALKYL; R6 AND R7 ARE H, C1-C6 ALKYL, OH, HALOGEN, C1-C6 ALCOXY; R9, R10 AND R11 ARE H, HALOGEN, NITRO, CYANE OR TRIFLUORMETHYL; A IS A GROUP a, b, c, d; A 5-7 MEMBER NON-AROMATIC N-HETEROCICLE OPTIONALLY CONTAINS O, NR14, CHR15, NR19R20; R12 AND R13 ARE H, HALOGEN, NITRO, CYANE, C1-C6 ALKYL, C1-C6 ALCOXY, OH; R14 AND R15 ARE H, C3-C8 CYCLOALKYL, C1-C4 ALKYL, C6-C10 ARYL, 5-6 MEMBER HETERO CYCLE, OPTIONALLY SUBSTITUTED WITH HALOGEN, CYANE, OH, NR16R17, AMONG OTHERS; OR R14 IS -SO2-R18; R16 AND R17 ARE H, C1-C4 ALKYL, C1-C4 ACILO, SO2-CF3 OR TOGETHER WITH N FORM AN AROMATIC HETEROCICLE OF 5-7 MEMBERS; R18 IS C6-C10 ARYL, C1-C4 ALKYL; R19 IS H, C1-C4 ALKYL; R20 IS D-E-R21; D IS C1-C6 ALKYL; E IS A LINK, OR; R21 IS C6-C10 ARYL, 5-6 MEMBER HETEROCYCLE OPTIONALLY SUBSTITUTED WITH NITRO, CYANE, HALOGEN, TETRAZOLYL, NR22R23; R22 AND R23 ARE H, C1-C6 ACYL, C1-C6 ALKYL; R22 IS H; AND R23 IS SO2-CF3. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. THE FORMULA I COMPOUND INHIBITS TRIPTASE SO IT MAY BE USEFUL FOR THE TREATMENT OF ASTHMA, ALLERGIC RHINITIS

PE1999000986A 1998-10-01 1999-09-29 NEW BIS-BENZIMIDAZOLES PE20001057A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10271198P 1998-10-01 1998-10-01
US11726999P 1999-01-26 1999-01-26
US12327799P 1999-03-09 1999-03-09

Publications (1)

Publication Number Publication Date
PE20001057A1 true PE20001057A1 (en) 2001-01-03

Family

ID=27379394

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000986A PE20001057A1 (en) 1998-10-01 1999-09-29 NEW BIS-BENZIMIDAZOLES

Country Status (9)

Country Link
EP (1) EP1117651A1 (en)
JP (1) JP2002526537A (en)
AR (1) AR021838A1 (en)
AU (1) AU5998199A (en)
CA (1) CA2346040A1 (en)
CO (1) CO5261509A1 (en)
GT (1) GT199900167A (en)
PE (1) PE20001057A1 (en)
WO (1) WO2000020401A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR024158A1 (en) * 1999-06-01 2002-09-04 Smithkline Beecham Corp ANTIBACTERIAL COMPOUNDS
BR0315166A (en) * 2002-10-11 2005-08-16 Astrazeneca Ab Use of a compound or a pharmaceutically acceptable salt thereof, a compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, and method for producing an inhibitory effect of 11betahsd1 on a warm-blooded animal such as man needing treatment
WO2012027495A1 (en) 2010-08-27 2012-03-01 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
EP3366685A1 (en) * 2012-01-09 2018-08-29 X-Chem, Inc. Tryptoline derivatives having kinase inhibitory activity and uses thereof
EP3495357B1 (en) * 2013-03-14 2021-05-05 The Trustees of Columbia University in the City of New York 4-phenylpiperidines, their preparation and use
US10478431B2 (en) 2014-11-26 2019-11-19 The J. David Gladstone Institutes Methods for treating a cytomegalovirus infection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0720603A1 (en) * 1993-09-22 1996-07-10 The Wellcome Foundation Limited Bis(amidinobenzimidazolyl)alkanes as antiviral agents
US5693515A (en) * 1995-04-28 1997-12-02 Arris Pharmaceutical Corporation Metal complexed serine protease inhibitors
KR20010006119A (en) * 1997-04-07 2001-01-26 액시스 파마슈티컬스 인코포레이티드 Compounds and compositions for treating diseases associated with serine protease, particularly tryptase, activity
WO1999026932A1 (en) * 1997-11-26 1999-06-03 Axys Pharmaceuticals, Inc. By amidino group substituted heterocyclic derivatives and their use as anticoagulants

Also Published As

Publication number Publication date
GT199900167A (en) 2001-03-21
AU5998199A (en) 2000-04-26
AR021838A1 (en) 2002-08-07
CA2346040A1 (en) 2000-04-13
WO2000020401A1 (en) 2000-04-13
EP1117651A1 (en) 2001-07-25
CO5261509A1 (en) 2003-03-31
JP2002526537A (en) 2002-08-20

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