PE20000706A1 - PROPENYL CEPHALOSPORIN DERIVATIVES - Google Patents

PROPENYL CEPHALOSPORIN DERIVATIVES

Info

Publication number
PE20000706A1
PE20000706A1 PE1999000556A PE00055699A PE20000706A1 PE 20000706 A1 PE20000706 A1 PE 20000706A1 PE 1999000556 A PE1999000556 A PE 1999000556A PE 00055699 A PE00055699 A PE 00055699A PE 20000706 A1 PE20000706 A1 PE 20000706A1
Authority
PE
Peru
Prior art keywords
alkyl
propenyl
refers
ring
aza
Prior art date
Application number
PE1999000556A
Other languages
Spanish (es)
Inventor
Ingrid Heinze-Krauss
Hans G F Richter
Erwin Gotschi
Peter Angehrn
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20000706A1 publication Critical patent/PE20000706A1/en

Links

Landscapes

  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE CEFALOSPORINA DE FORMULA I, DONDE R ES UN RESIDUO DE PESO MOLECULAR NO SUPERIOR A 400; R1 ES H, ALQUILO, FENILO; A ES NITROGENO UNIDO A PROPENILO Y SUSTITUIDO POR UN RESIDUO DE PESO MOLECULAR NO SUPERIOR A 400. TAMBIEN SE REFIERE A UN COMPUESTO DE FORMULA II, DONDE R° ES ALQUILO, ALQUENILO, OPCIONALMENTE SUSTITUIDO CON R7; R7 ES HALOGENO, CICLOALQUILO, NAFTILO, ENTRE OTROS; A0 ES -N+R2R3R4; R2, R3, R4 ALQUILO, CICLOALQUILO, (ALQUENIL)(ALQUILO), HETEROCICLO; O R2 Y R3 JUNTO CON N FORMAN UN ANILLO HETEROCICLO DE 5-8 MIEMBROS; R4 ES UN PUENTE 1,4-ALQUILENO, VINILENO CON EL ANILLO HETEROCICLO QUE FORMAN R2 Y R3; R2, R3 Y R4 JUNTO CON N SON UN ANILLO DE 5-6 MIEMBROS. SON COMPUESTOS PREFERIDOS (E)-(6R,7R)-8-OXO-7-(2-FENILSULFANIL-ACETILAMINO)-3-(3-PIRIDIN-1-IO-1-IL-PROPENIL)-5-TIA-1-AZA-BICICLO[4.2.0]OCT-2-EN-2-CARBOXILATO; (E)-(6R,7R)-7-[2-(5-ETOXICARBONIL-4-METIL-TIAZOL-2-ILSULFANIL)ACETILAMINO]-8-OXO-3-(3-PIRIDIN-1-IO-1-IL)-PROPENIL)-5-TIA-1-AZABICICLO[4.2.0]OCT-2-EN-2-CARBOXILATO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION Y COMPUESTOS INTERMEDIOS. ASI COMO A UNA COMPOSICION QUE COMPRENDE ADEMAS UN CARBAPENEM (IMIPENEM), INHIBIDOR DE ß-LACTAMASA (Z)-(2S,3S,5R)-3-(2-CIANOETIL)-3-METIL-4,4,7-TRIOXO-4-TIAZA-1-AZA-BICICLO[3.2.0]HEPTANO-2-CARBOXILICOREFERS TO CEPHALOSPORIN DERIVATIVES OF FORMULA I, WHERE R IS A RESIDUE WITH A MOLECULAR WEIGHT NOT EXCEEDING 400; R1 IS H, ALKYL, PHENYL; A IS NITROGEN BOUND TO PROPENYL AND SUBSTITUTED BY A RESIDUE OF MOLECULAR WEIGHT NOT EXCEEDING 400. ALSO REFERS TO A COMPOUND OF FORMULA II, WHERE R ° IS ALKYL, ALKENYL, OPTIONALLY SUBSTITUTED WITH R7; R7 IS HALOGEN, CYCLOALKYL, NAPHTHYL, AMONG OTHERS; A0 IS -N + R2R3R4; R2, R3, R4 ALKYL, CYCLOALKYL, (ALKENYL) (ALKYL), HETEROCYCLE; OR R2 AND R3 TOGETHER WITH N FORM A 5-8 MEMBER HETERO CYCLE RING; R4 IS A 1,4-ALKYLENE, VINYLENE BRIDGE WITH THE HETEROCYCLE RING FORMING R2 AND R3; R2, R3 AND R4 TOGETHER WITH N ARE A RING OF 5-6 MEMBERS. PREFERRED COMPOUNDS ARE (E) - (6R, 7R) -8-OXO-7- (2-PHENYLSULPHANIL-ACETYLAMINE) -3- (3-PYRIDIN-1-IO-1-IL-PROPENYL) -5-TIA-1 -AZA-BICYCLE [4.2.0] OCT-2-IN-2-CARBOXYLATE; (E) - (6R, 7R) -7- [2- (5-ETOXYCARBONYL-4-METHYL-THIAZOL-2-ILSULFANIL) ACETHYLAMINE] -8-OXO-3- (3-PYRIDIN-1-IO-1- IL) -PROPENYL) -5-THIA-1-AZABICYCLE [4.2.0] OCT-2-EN-2-CARBOXYLATE, AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR THE PREPARATION AND INTERMEDIATE COMPOUNDS. AS WELL AS A COMPOSITION THAT ALSO INCLUDES A CARBAPENEM (IMIPENEM), INHIBITOR OF ß-LACTAMASE (Z) - (2S, 3S, 5R) -3- (2-CYANOETHYL) -3-METHYL-4,4,7-TRIOXO -4-TIAZA-1-AZA-BICYCLE [3.2.0] HEPTANE-2-CARBOXYL

PE1999000556A 1998-06-22 1999-06-22 PROPENYL CEPHALOSPORIN DERIVATIVES PE20000706A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98111415 1998-06-22

Publications (1)

Publication Number Publication Date
PE20000706A1 true PE20000706A1 (en) 2000-08-22

Family

ID=27675828

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000556A PE20000706A1 (en) 1998-06-22 1999-06-22 PROPENYL CEPHALOSPORIN DERIVATIVES

Country Status (4)

Country Link
AR (1) AR018905A1 (en)
CO (1) CO5080796A1 (en)
PE (1) PE20000706A1 (en)
ZA (1) ZA200007074B (en)

Also Published As

Publication number Publication date
AR018905A1 (en) 2001-12-12
ZA200007074B (en) 2002-05-30
CO5080796A1 (en) 2001-09-25

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Legal Events

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