PE20000174A1 - PYRIDINYLPYRIMIDINAMINES - Google Patents

PYRIDINYLPYRIMIDINAMINES

Info

Publication number
PE20000174A1
PE20000174A1 PE1999000018A PE00001899A PE20000174A1 PE 20000174 A1 PE20000174 A1 PE 20000174A1 PE 1999000018 A PE1999000018 A PE 1999000018A PE 00001899 A PE00001899 A PE 00001899A PE 20000174 A1 PE20000174 A1 PE 20000174A1
Authority
PE
Peru
Prior art keywords
alkyl
halogen
refers
compound
alcoxy
Prior art date
Application number
PE1999000018A
Other languages
Spanish (es)
Inventor
Peter Etimayer
Max Woisetschager
Volker Brinkmann
Christoph Heusser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9800522.6A external-priority patent/GB9800522D0/en
Priority claimed from GBGB9800520.0A external-priority patent/GB9800520D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20000174A1 publication Critical patent/PE20000174A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

SE REFIERE AL NUEVO USO DE PIRIDINILPIRIMIDINAMINAS DE FORMULA I; R1 ES HALOGENO, FENILO, ALQUILO; R2 ES H, HALO, ALQUILO, ALCOXI, TRIFLUOROMETILO, EN LA PREPARACION DE UN MEDICAMENTO PARA LA TERAPIA DE ENFERMEDADES MEDIADAS POR IgE (INMUNOGLOBULINA E). TAMBIEN SE REFIERE A UN COMPUESTO DE FORMULA Ib DONDE; R1`' ES HALOGENO CON UN NUMERO ATOMICO 17 o 35 Y R2'' ES H o ALCOXI O BIEN R1'' ES FENILO O ALQUILO, R2'' ES H, HALOGENO, ALQUILO, ALCOXI, TRIFLUOROMETILO. UN COMPUESTO PREFERIDO N-(3-METILFENIL)-N-[4-(2-METILPIRIDIN-4-IL)PIRIMIDIN-2-IL]AMINA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ACTUA COMO INHIBIDOR ESPECIFICO DE LA SINTESIS DE INMUNOGLOBULINA E (IgE) EN LOS LINFOCITOS B Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ENFERMEDADES TAL COMO DERMATITIS ATOPICA, ASMA ALERGICA, CONJUNTIVITIS ALERGICA Y RINITIS ALERGICAREFERS TO THE NEW USE OF PYRIDINYLPYRIMIDINAMINES OF FORMULA I; R1 IS HALOGEN, PHENYL, ALKYL; R2 IS H, HALO, ALKYL, ALCOXY, TRIFLUOROMETHYL, IN THE PREPARATION OF A DRUG FOR THE THERAPY OF IgE-MEDIATED DISEASES (IMMUNOGLOBULIN E). ALSO REFERS TO A COMPOUND OF FORMULA Ib WHERE; R1` 'IS HALOGEN WITH AN ATOMIC NUMBER 17 or 35 AND R2' 'IS H or ALCOXI OR R1' 'IS PHENYL OR ALKYL, R2' 'IS H, HALOGEN, ALKYL, ALCOXY, TRIFLUOROMETHYL. A PREFERRED COMPOUND N- (3-METHYLPHENYL) -N- [4- (2-METHYLPYRIDIN-4-IL) PYRIMIDIN-2-IL] AMINE. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. COMPOUND I ACTS AS A SPECIFIC INHIBITOR OF THE SYNTHESIS OF IMMUNOGLOBULIN E (IgE) IN B LYMPHOCYTES AND MAY BE USEFUL FOR THE TREATMENT OF DISEASES SUCH AS ATOPIC DERMATITIS, ALLERGIC ASTHMA, ALLERGIC CONJUNCTIVITIS AND ALLERGIC RHINITIS

PE1999000018A 1998-01-12 1999-01-08 PYRIDINYLPYRIMIDINAMINES PE20000174A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9800522.6A GB9800522D0 (en) 1998-01-12 1998-01-12 Organic compounds
GBGB9800520.0A GB9800520D0 (en) 1998-01-12 1998-01-12 Organic compounds

Publications (1)

Publication Number Publication Date
PE20000174A1 true PE20000174A1 (en) 2000-03-17

Family

ID=26312926

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000018A PE20000174A1 (en) 1998-01-12 1999-01-08 PYRIDINYLPYRIMIDINAMINES

Country Status (5)

Country Link
AR (1) AR014288A1 (en)
AU (1) AU2516199A (en)
CO (1) CO4940461A1 (en)
PE (1) PE20000174A1 (en)
WO (1) WO1999035140A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0025820D0 (en) * 2000-10-20 2000-12-06 Novartis Ag Organic compounds
US6890940B2 (en) 2001-06-29 2005-05-10 Kowa Co., Ltd. Bis(2-aryl-5-pyridyl) derivatives
US6706703B2 (en) 2001-06-29 2004-03-16 Kowa Co., Ltd. Bis(5-aryl-2-pyridyl) derivatives
AR038368A1 (en) 2002-02-01 2005-01-12 Novartis Ag N-PYRIMIDIN-2-IL-AMINAS SUBSTITUTED COMPOUNDS AS IGE INHIBITORS, A PHARMACEUTICAL COMPOSITION AND THE USE OF SUCH COMPOUNDS FOR THE PREPARATION OF A MEDICINAL PRODUCT
JP2012508723A (en) * 2008-11-14 2012-04-12 バイエル・クロップサイエンス・アーゲー Substituted (pyridyl) -azinylamine derivatives as plant protection agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3474817D1 (en) * 1983-09-01 1988-12-01 Boehringer Ingelheim Ltd Diazine-ethenylphenyl oxamic acids and esters and salts thereof
US5728708A (en) * 1993-10-01 1998-03-17 Novartis Corporation Pharmacologically active pyridine derivatives and processes for the preparation thereof
EP0672042B1 (en) * 1993-10-01 2006-05-03 Novartis AG Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof

Also Published As

Publication number Publication date
AU2516199A (en) 1999-07-26
AR014288A1 (en) 2001-02-07
CO4940461A1 (en) 2000-07-24
WO1999035140A1 (en) 1999-07-15

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Legal Events

Date Code Title Description
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