PE118899A1 - METHOD TO INCREASE THE BONE VOLUME - Google Patents

METHOD TO INCREASE THE BONE VOLUME

Info

Publication number
PE118899A1
PE118899A1 PE1998000855A PE00085598A PE118899A1 PE 118899 A1 PE118899 A1 PE 118899A1 PE 1998000855 A PE1998000855 A PE 1998000855A PE 00085598 A PE00085598 A PE 00085598A PE 118899 A1 PE118899 A1 PE 118899A1
Authority
PE
Peru
Prior art keywords
tetr
agent
increase
bone
prostaglandin
Prior art date
Application number
PE1998000855A
Other languages
Spanish (es)
Inventor
James Richard Hartke
Mitchell Anthony Delong
Mark Walden Lundy
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE118899A1 publication Critical patent/PE118899A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Abstract

SE REFIERE AL USO DE UN AGENTE QUE ACTIVA LAS RUTAS DE CALCIO INTRACELULARES DE QUINASA C OSTEOBLASTICAS, EL AGENTE PUEDE SER UN AGONISTA DEL RECEPTOR FP, TAL COMO UN ANALOGO DE PROSTAGLANDINA DE FORMULA I, DONDE R1 ES OH, AMINA, ESTER DE 1-12 MIEMBROS; X ES (CH2)n, NH, S, O; n ES 0-2; Y ES CICLOALQUIL O UN GRUPO AROMATICO. LOS ANALOGOS DE PROSTAGLANDINA SON DE PREFERENCIA CLOPROSTENOL, FLUPROSTENOL, TIAPROST, ALFAPROSTOL, DELPROSTENATO, FROXIPROST, ACIDO 9,11,15-O-TRIHIDROXI-16-(3-CLOROFENOXI)-OMEGA-TETRANOR-PROSTA-4-CIS-13-TRANS-DIENOICO, ENTRE OTROS. ESTE AGENTE ES USADO PARA AUMENTAR EL VOLUMEN OSEO Y PARA EL TRATAMIENTO DE UN TRASTORNO OSEO TAL COMO OSTEOPOROSIS, OSTEOARTRITIS, ENFERMEDAD DE PAGET, OSTEOMALACIA Y FRACTURA DE HUESO. EL AGONISTA FP ES SELECTIVO PARA EL RECEPTOR FP EN RELACION A OTROS RECEPTORES EXCITADORES DE PROSTAGLANDINAS EN UNA PROPORCION DE 1:10REFERING TO THE USE OF AN AGENT THAT ACTIVATES THE INTRACELLULAR CALCIUM ROUTES OF C OSTEOBLASTIC QUINASA, THE AGENT MAY BE AN AGONIST OF THE RECEPTOR FP, SUCH AS AN ANALOG OF PROSTAGLANDINE OF FORMULA I, WHERE R1 IS OH, AMINE, ESTER OF 1- 12 MEMBERS; X IS (CH2) n, NH, S, O; n ES 0-2; AND IT'S A CYCLOALQUIL OR AROMATIC GROUP. THE ANALOGS OF PROSTAGLANDIN ARE OF PREFERENCE CLOPROSTENOL, FLUPROSTENOL, TIAPROST, ALFAPROSTOL, DELPROSTENATO, FROXIPROST, ACID 9,11,15-O-TRIHIDROXI-16- (3-CHLOROPHENOXI-TETR-TETR-TETR-4-TETR-TETR-4 TRANS-DIENOIC, AMONG OTHERS. THIS AGENT IS USED TO INCREASE THE BONE VOLUME AND FOR THE TREATMENT OF A BONE DISORDER SUCH AS OSTEOPOROSIS, OSTEOARTRITIS, PAGET DISEASE, OSTEOMALACY, AND BONE FRACTURE. THE FP AGONIST IS SELECTIVE FOR THE FP RECEIVER IN RELATION TO OTHER PROSTAGLANDIN EXCITATOR RECEPTORS IN A PROPORTION OF 1:10

PE1998000855A 1997-09-09 1998-09-09 METHOD TO INCREASE THE BONE VOLUME PE118899A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5821897P 1997-09-09 1997-09-09

Publications (1)

Publication Number Publication Date
PE118899A1 true PE118899A1 (en) 2000-02-03

Family

ID=22015432

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000855A PE118899A1 (en) 1997-09-09 1998-09-09 METHOD TO INCREASE THE BONE VOLUME

Country Status (17)

Country Link
EP (1) EP1035853A1 (en)
JP (1) JP2001515863A (en)
CN (1) CN1269720A (en)
AR (1) AR013478A1 (en)
AU (1) AU9130298A (en)
BR (1) BR9811775A (en)
CA (1) CA2303799A1 (en)
CO (1) CO5070621A1 (en)
HU (1) HUP0003584A3 (en)
ID (1) ID24759A (en)
IL (1) IL134759A0 (en)
NO (1) NO20001172L (en)
PE (1) PE118899A1 (en)
PL (1) PL339297A1 (en)
SK (1) SK3402000A3 (en)
WO (1) WO1999012550A1 (en)
ZA (1) ZA988229B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU766163B2 (en) 1999-03-05 2003-10-09 Duke University C16 unsaturated fp-selective prostaglandins analogs
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3607293A (en) * 1992-02-05 1993-09-03 Merck & Co., Inc. Implant therapy for bone growth stimulation
HN1996000101A (en) * 1996-02-28 1997-06-26 Inc Pfizer COMBINED THERAPY FOR OSTEOPOROSIS

Also Published As

Publication number Publication date
SK3402000A3 (en) 2000-12-11
WO1999012550A1 (en) 1999-03-18
IL134759A0 (en) 2001-04-30
CO5070621A1 (en) 2001-08-28
BR9811775A (en) 2000-08-29
JP2001515863A (en) 2001-09-25
CN1269720A (en) 2000-10-11
HUP0003584A2 (en) 2001-02-28
ID24759A (en) 2000-08-03
NO20001172L (en) 2000-05-08
PL339297A1 (en) 2000-12-04
AU9130298A (en) 1999-03-29
HUP0003584A3 (en) 2002-12-28
EP1035853A1 (en) 2000-09-20
AR013478A1 (en) 2000-12-27
ZA988229B (en) 1999-03-09
CA2303799A1 (en) 1999-03-18
NO20001172D0 (en) 2000-03-07

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