PE105099A1 - PEPTIDES AND COMPOUNDS THAT BIND TO THE IL-5 RECEPTOR - Google Patents

PEPTIDES AND COMPOUNDS THAT BIND TO THE IL-5 RECEPTOR

Info

Publication number
PE105099A1
PE105099A1 PE1998000496A PE00049698A PE105099A1 PE 105099 A1 PE105099 A1 PE 105099A1 PE 1998000496 A PE1998000496 A PE 1998000496A PE 00049698 A PE00049698 A PE 00049698A PE 105099 A1 PE105099 A1 PE 105099A1
Authority
PE
Peru
Prior art keywords
peptide
terminal
composition
nr3r4
nrc
Prior art date
Application number
PE1998000496A
Other languages
Spanish (es)
Inventor
Bruce Padon England
Min-Jia Chen
Ronald William Barret
Peter Joseph Schatz
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE105099A1 publication Critical patent/PE105099A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5409—IL-5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

SE REFIERE A UNA COMPOSICION QUE COMPRENDE UN PEPTIDO CON UNA SECUENCIA DE 12 A 25 AMINOACIDOS Y SUS DIMEROS U OLIGOMEROS, QUE SE CARACTERIZA POR a)UN PESO MOLECULAR MENOR DE 5000 DALTONS; b)UNA AFINIDAD DE UNION A LOS RECEPTORES DE INTERLEUCINA 5 (IL5-R); DONDE UNO O MAS DE LOS ENLACES DEL RESTO -C(O)NH- DEL PEPTIDO HA SIDO REEMPLAZADO POR -CH2OC(O)NR-, FOSFONATO, CH2S(O)2NR-, -C(O)NR6, ENTRE OTROS; EL N-TERMINAL DEL PEPTIDO ES NRR1, -NRC(O)R, NRC(O)OR, ENTRE OTROS; EL C-TERMINAL DEL PEPTIDO ES -C(O)R2; R2 ES OH, ALCOXI, -NR3R4; R, R1, R3 Y R4 SON H Y ALQUILO; R6 ES ALQUILO; EL NITROGENO DE NR3R4 PUEDE SER EL GRUPO AMINO DEL N-TERMINAL Y FORMAR UN PEPTIDO CICLICO; LAS CISTEINAS PRESENTES EN EL PEPTIDO SON CICLIZADAS A TRAVES DE UN ENLACE DE DISULFURO INTRAMOLECULAR. EL PEPTIDO ESTA PRESENTE EN UNA CONCENTRACION DESDE 0,1 A 100 mg/ml. LA COMPOSICION TAMBIEN COMPRENDE UN AGONISTA �-ADRENERGICO, CORTICOESTEROIDE, BROMURO DE IPATROPIO. LA COMPOSICION SE PRESENTA EN FORMA DE AEROSOL. EL PEPTIDO PUEDE SER UTIL PARA TRATAR TRASTORNOS INFLAMATORIOS INMUNOMEDIADOS, COMO EL ASMAREFERS TO A COMPOSITION THAT INCLUDES A PEPTIDE WITH A SEQUENCE OF 12 TO 25 AMINO ACIDS AND THEIR DIMERS OR OLIGOMERS, WHICH IS CHARACTERIZED BY a) A MOLECULAR WEIGHT LESS THAN 5000 DALTONS; b) A BINDING AFFINITY TO INTERLEUKIN 5 RECEPTORS (IL5-R); WHERE ONE OR MORE OF THE LINKS OF THE REST -C (O) NH- OF THE PEPTIDE HAS BEEN REPLACED BY -CH2OC (O) NR-, PHOSPHONATE, CH2S (O) 2NR-, -C (O) NR6, AMONG OTHERS; THE N-TERMINAL OF THE PEPTIDE IS NRR1, -NRC (O) R, NRC (O) OR, AMONG OTHERS; THE C-TERMINAL OF THE PEPTIDE IS -C (O) R2; R2 IS OH, ALCOXY, -NR3R4; R, R1, R3 AND R4 ARE H AND ALKYL; R6 IS RENT; THE NITROGEN OF NR3R4 MAY BE THE AMINO GROUP OF THE N-TERMINAL AND FORM A CYCLIC PEPTIDE; THE CYSTEINS PRESENT IN THE PEPTIDE ARE CYCLIZED THROUGH AN INTRAMOLECULAR DISULFIDE LINKAGE. THE PEPTIDE IS PRESENT IN A CONCENTRATION FROM 0.1 TO 100 mg / ml. THE COMPOSITION ALSO INCLUDES A �-ADRENERGIC AGONIST, CORTICOESTEROID, IPATROPIUM BROMIDE. THE COMPOSITION IS PRESENTED IN THE FORM OF AEROSOL. PEPTIDE MAY BE USEFUL TO TREAT IMMUNE-MEDIATED INFLAMMATORY DISORDERS, SUCH AS ASTHMA

PE1998000496A 1997-06-14 1998-06-11 PEPTIDES AND COMPOUNDS THAT BIND TO THE IL-5 RECEPTOR PE105099A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9712410.1A GB9712410D0 (en) 1997-06-14 1997-06-14 Peptides and compounds that bind to the il-5 receptor

Publications (1)

Publication Number Publication Date
PE105099A1 true PE105099A1 (en) 1999-11-10

Family

ID=10814166

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000496A PE105099A1 (en) 1997-06-14 1998-06-11 PEPTIDES AND COMPOUNDS THAT BIND TO THE IL-5 RECEPTOR

Country Status (10)

Country Link
EP (1) EP0980385A1 (en)
JP (1) JP2002515070A (en)
AR (1) AR012973A1 (en)
AU (1) AU7919498A (en)
GB (1) GB9712410D0 (en)
HR (1) HRP980323A2 (en)
MA (1) MA26506A1 (en)
PE (1) PE105099A1 (en)
WO (1) WO1998057979A1 (en)
ZA (1) ZA985101B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1145066T3 (en) 1998-12-21 2005-07-04 Evotec Ag Positioning the measurement volume in a scanning microscopic method
US7109299B1 (en) 1999-12-16 2006-09-19 Affymax, Inc. Peptides and compounds that bind to the IL-5 receptor
AU3125500A (en) * 1999-12-16 2001-06-25 Glaxo Group Limited Peptides and compounds that bind to the il-5 receptor
BR112018003741A2 (en) 2015-08-24 2018-09-25 Glaxosmithkline Ip No 2 Ltd biopharmaceutical compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677280A (en) * 1995-06-07 1997-10-14 Glaxo Group Limited Peptides and compounds that bind to the IL-5 receptor
US5668110A (en) * 1995-06-07 1997-09-16 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US5654276A (en) * 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US5683983A (en) * 1995-06-07 1997-11-04 Glaxo Group Limited Peptides and compounds that bind to the IL-5 receptor

Also Published As

Publication number Publication date
WO1998057979A1 (en) 1998-12-23
AR012973A1 (en) 2000-11-22
EP0980385A1 (en) 2000-02-23
JP2002515070A (en) 2002-05-21
HRP980323A2 (en) 1999-04-30
ZA985101B (en) 1999-12-13
GB9712410D0 (en) 1997-08-13
AU7919498A (en) 1999-01-04
MA26506A1 (en) 2004-12-20

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