PA8600201A1 - ALFA CARBOXYLIC ACIDS REPLACED AS PPAR MODULATORS - Google Patents

ALFA CARBOXYLIC ACIDS REPLACED AS PPAR MODULATORS

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Publication number
PA8600201A1
PA8600201A1 PA20048600201A PA8600201A PA8600201A1 PA 8600201 A1 PA8600201 A1 PA 8600201A1 PA 20048600201 A PA20048600201 A PA 20048600201A PA 8600201 A PA8600201 A PA 8600201A PA 8600201 A1 PA8600201 A1 PA 8600201A1
Authority
PA
Panama
Prior art keywords
carboxylic acids
alfa
ppar modulators
acids replaced
ppar
Prior art date
Application number
PA20048600201A
Other languages
Spanish (es)
Inventor
Simon Bailey
Paul Stuart Humphries
Donald James Skalitzky
Wei-Guo Su
Luke Raymond Zehnder
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PA8600201A1 publication Critical patent/PA8600201A1/en

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
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    • C07—ORGANIC CHEMISTRY
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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
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    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Abstract

ACIDOS CARBOXILICOS ALFASUSTITUIDOS DE FORMULA (I): EN LA QUE R1 Y R2 SON COMO SE HAN DEFINIDO EN LA MEMORIA DESCRIPTIVA Y R3 ES A); B); C) Y D); EN LAS QUE Y, Ar1, Ar2, Ar3, R4, R5, R6, R7, R8, R9, R9A, R10, R11, R12, R17, ANILLO A, Y P SON COMO SE HAN DEFINDO EN LA MEMORIA DESCRIPTIVA; LAS COMPOSICIONES FARMACEUTICAS CONTENIENDO CANTIDADES EFICACES DE DICHOS COMPUESTOS O SUS SALES SON UTILES PARA TRATAR PPAR, ESPECIFICAMENTE TRASTORNOS RELACIONADOS CON PPAR A/Y, TALES COMO DIABETES, DISLIPIDEMIA, OBESIDAD Y TRASTORNOS INFLAMATORIOS.ALPHASUSTITUTED CARBOXYLIC ACIDS OF FORMULA (I): IN WHICH R1 AND R2 ARE AS DEFINED IN THE DESCRIPTIVE MEMORY AND R3 IS A); B); C) AND D); IN WHICH AND, Ar1, Ar2, Ar3, R4, R5, R6, R7, R8, R9, R9A, R10, R11, R12, R17, RING A, AND P ARE AS DEFINED IN THE DESCRIPTIVE MEMORY; PHARMACEUTICAL COMPOSITIONS CONTAINING EFFECTIVE AMOUNTS OF SUCH COMPOUNDS OR ITS SALTS ARE USEFUL TO TREAT PPAR, SPECIFICALLY DISORDERS RELATED TO PPAR A / Y, SUCH AS DIABETES, DISLIPIDEMIA, OBESITY AND INFLAMMATORY DISORDERS.

PA20048600201A 2003-04-15 2004-04-14 ALFA CARBOXYLIC ACIDS REPLACED AS PPAR MODULATORS PA8600201A1 (en)

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US46321303P 2003-04-15 2003-04-15

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EP (1) EP1615899A1 (en)
JP (1) JP2006523671A (en)
KR (1) KR20060009846A (en)
CN (1) CN1805943A (en)
AP (1) AP2005003418A0 (en)
AR (1) AR044514A1 (en)
AU (1) AU2004230316A1 (en)
BR (1) BRPI0409429A (en)
CA (1) CA2521915A1 (en)
CL (1) CL2004000800A1 (en)
EA (1) EA200501462A1 (en)
EC (1) ECSP056105A (en)
IS (1) IS8033A (en)
MA (1) MA27764A1 (en)
MX (1) MXPA05010967A (en)
NL (1) NL1025946C2 (en)
NO (1) NO20055370L (en)
OA (1) OA13157A (en)
PA (1) PA8600201A1 (en)
PE (1) PE20050415A1 (en)
TN (1) TNSN05262A1 (en)
TW (1) TW200510353A (en)
UY (1) UY28266A1 (en)
WO (1) WO2004092145A1 (en)
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AP2005003418A0 (en) 2005-12-31
NO20055370L (en) 2006-01-12
AR044514A1 (en) 2005-09-14
JP2006523671A (en) 2006-10-19
CA2521915A1 (en) 2004-10-28
TW200510353A (en) 2005-03-16
KR20060009846A (en) 2006-02-01
ZA200508362B (en) 2006-11-29
EP1615899A1 (en) 2006-01-18
CL2004000800A1 (en) 2005-03-04
OA13157A (en) 2006-12-13
WO2004092145A1 (en) 2004-10-28
MXPA05010967A (en) 2005-11-28
UY28266A1 (en) 2004-11-30
EA200501462A1 (en) 2006-04-28
IS8033A (en) 2005-09-15
TNSN05262A1 (en) 2007-07-10
WO2004092145A8 (en) 2005-05-12
PE20050415A1 (en) 2005-06-13
NO20055370D0 (en) 2005-11-14
CN1805943A (en) 2006-07-19
AU2004230316A1 (en) 2004-10-28
MA27764A1 (en) 2006-02-01
BRPI0409429A (en) 2006-04-18
NL1025946C2 (en) 2005-02-01
NL1025946A1 (en) 2004-10-18
ECSP056105A (en) 2006-03-01

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