OA20699A - Electrical system for treatment of a subject - Google Patents

Electrical system for treatment of a subject Download PDF

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OA20699A
OA20699A OA1202200158 OA20699A OA 20699 A OA20699 A OA 20699A OA 1202200158 OA1202200158 OA 1202200158 OA 20699 A OA20699 A OA 20699A
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cancer
frequencies
digital
frequency
signais
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OA1202200158
Inventor
Alexandre Barbault
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Therabionic, Inc
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Abstract

The systems and methods of this disclosure are directed to the treatment of disease states, and particularly different types of cancer, by application of low energy emission therapy. The device and method provide treatments of disease states in a patient, and particularly of cancer types, by the application to the patient of particular and disease- specific low energy high frequency radiation. The device uses a high precision frequency synthesizer to generate radio frequency radiation that is amplitude-modulated at identified tumor-specific frequencies for application to the patient during therapy

Description

ELECTRICAL SYSTEM FOR TREATMENT OF A SUBJECT
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application daims priority under 35 U.S.C. § 119(e) to U.S. Provisional Patent Application Serial No. 62/923,908, filed on October 21, 2019 and U.S. Provisional Patent 5 Application Serial No. 62/934,212, filed on November 12, 2019, and which are hereby incorporated by reference in their entirety.
FIELD OF INVENTION
[0002] This invention relates to Systems and methods for treatment of a subject using low energy high frequency radiation. The electronic System and prograæmed control thereof has therapeutic 10 application for influencing cellular functions (or malfunctions), including directly or indirectly influencing cancerous cell growth or prolifération thereof in warm-blooded mammalian subjects. The device and method of the invention provide treatments of different cancer types by the application to the patient of electromagnetic fields that are amplitude-modulated at particular and cancer-specific frequencies.
BACKGROUND OF INVENTION
[0003] Reference is made to European Paient EP 0 592 851 B1 and corresponding patents and patent applications and to the various publications referred to thereîn, related to effects of very low energy electromagnetic fields on subjects. A number of further publications related to effects of very low energy electromagnetic fields on patients suffering from insomnîa and/or anxiety 20 disorders hâve taken place and are as follows:
• Koziol, J. A., Erman, M., Pasche B., Hajdukovic R., Mitler, Μ. M., (1993), “Assessing a changepoint in a sequence of repeated measurements with application to a low-energy émission therapy sleep study”. J. Applied Statistics 20: 393-400;
• Amato, D., Pasche, B., (1993), “An évaluation of the safety of low energy émission 25 therapy”. Compr Ther 19; 242-247;
• Higgs, L., Reite, M., Barbault, A., Lebet, J. P., Rossel, C., Amato, D., Dafni, U., Pasche.
B., (1994), “Subjective and Objective Relaxation Effects of Low Energy Emission
Therapy”. Stress Medicine 10: 5-13;
• Reite, M., Higgs, L, Lebet, J. P., Barbault, A., Rossel, C., Kuster, N., Dafni, U., Amato, D., Pasche, B., (1994), “Sleep Inducing Effect of Low Energy Emission
Therapy”. Bioelectromagnetics 15: 67-75.
• Lebet, J. P., Barbault, A., Rossel, C., Tomic, Z., Reite, M., Higgs, L., Dafni, U., Amato, D., Pasche, B,, (1996), “Electroencephalographic changes following low energy émission therapy”. Ann Biomed Eng 24: 424-429;
• Pasche, B., Erman, M., Hayduk, R., Mitler, M., Reite, M., Higgs, L., Dafni, U., Amato, D., Rossel, C., Kuster, N., Barbault, A., Lebet, J. P., (1996), “Effects of Low Energy Emission Therapy in chronic psychophysiological insomnia”. Sleep 19: 327-336;
• Kelly, T. L., Kripke, D. F., Hayduk, R., Ryman, D., Pasche, B., Barbault, A., (1997), “Bright light and LEET effects on circadian rhythms, sleep and cognitive performance”. Stress Medicine 13: 251-258; and • Pasche, B., Barbault, A., (2003), “Low-Energy Emission Therapy Current Status and Future Directions. In Bioelectromagnetic Medicine, Rosch, P. J., Markov, M. S. (eds.), pages 321-327, Marcel Dekker, Inc.: New York, N.Y.
[0004] The above publications are related to an earlier device, System and use thereof described in said EP 0 592 851 Bl.
[0005] Electromagnetic energy generating devices and use of electromagnetic energies for treating living mammalian subjects harboring cancerous cells described in the literature include: ILS. Pat. No. 5,908,441 issued Jun. 1,1999 to James E. Bare and the references cited therein and so-called “NovoCure technology” involving in vivo implantation of électrodes to either side of tumorous growths. The method of this patent is invasive as it involves implantation of électrodes into the patient. This may also render the method unsuitable for treatment of some tumor types. This patent does not contemplate very low energy émissions of electromagnetic energy involving amplitude-modulated high frequency carrier signais as requîred in tenus of the présent invention. [0006J U.S. Pat. No. 5,690,692 issued Nov. 25, 1997 entitled “Bio-Active Frequency Generator and Method” describes a programmable control which instructs a frequency synthesizer to enable génération of an electrical current at a spécifie précisé frequency signal or at a sériés of spécifie précisé frequency signais having a square wave form to within an accuracy of 0.001 Hz. This patent contemplâtes amplifying the voltage of the generated signais and applying the signais to a subject at the spécifie précisé frequency or sequentîally at the sériés of spécifie précisé frequencies by means of électrodes held by or otherwîse connected to the subject (which may be a mammal or a food). This patent also does not contem plate very low energy émissions of electromagnetic energy involving amplitude-modulated high frequency carrier signais as required in terms of the présent invention.
[0007] U.S. Pat. No. 8,977,365 issued March 10, 2015 entitled “Electronic System For Influencing Cellular Functions In A Warm-Blooded Mammalian Subject” describes an electronic System activatable by electrical power is useful for influencing cellular functions or malfunctions in a warm-blooded mammalian subject. The System includes one or more controllabié low energy HF (High Frequency) carrier signai generator circuits, one or more data processors for receivîng control information, one or more amplitude modulation control generators and one or more amplitude modulation frequency control generators. The amplitude modulation frequency control generators are adapted to accurately control the frequency of the amplitude modulations to within an accuracy of at least 100Ü ppm, most preferably to within about 1 ppm, relative to one or more determined or predetermined reference amplitude modulation frequencies. While the improved electronic System and programmed control thereof in accordance with U.S. Pat. No. 8,977,365, were shown to directiy or indirectly influence cancerous cell growth or prolifération thereof in warm-blooded mammalian subjects, this patent utilized an analog synthesizer for generating a carrier signal and lead to a classy output signal.
[0008] The device and method of the instant invention is generally non-invasive, without the need of implanted électrodes. The method and device provided herein applies very low energy émissions of electromagnetic energy with precisely determined amplitude-modulated frequencies to a patient, particularly for the treatment of cancer.
[0009] There is a gréai need for improved cancer thérapies to expand the treatment options for cancer. The need is particularly acute for the treatment of cancers that are difficult to treat or are résistant to treatment, such as refractory cancers, cancers in which other treatment options hâve lost effectiveness, and metastasized cancers and particularly in metastasis to the bone and brain. The Systems and methods of the current disclosure provide treatments of cancer which fulfîll these and other needs as discussed in detail below.
SUMMARY OFTHE INVENTION
[0010] The Systems and methods of the current disclosure are directed to the treatment of different types of cancer by application of low energy émission therapy. Such Systems and methods hâve been detennined to find therapeutic application not only for influencing cellular fonctions (or malfunctîons) leading to central nervous System (CNS) dîsorders, but more particularly for influencing other cellular fonctions (or malfunctîons), including directly or indîrectly influencing cancerous cell growth or prolifération thereof in warm-blooded mammalian subjects. The direct 5 or indirect influence on cancerous cell growth may involve, but is not necessarily lîmited to, any of prophylactic avoidance of cancerous cell formation, influencing of cell fonctions such as for example influencing leukocyte cell fonctions which can lead to inhibition of cancerous cell growth or prolifération thereof, and/or killing of cancerous cells harbored by a warm-blooded mammalian subject.
[0011] In one aspect, the invention provides an apparatus for treating a subject suffering from cancer, the apparatus comprising (i) a conductive applicator configured to apply to the subject low energy high frequency radiation, wherein the low energy high frequency radiation comprises one or more amplitude-modulated output signais; and (ii) a frequency synthesizer coupled to the conductive applicator and configured to generate the one or more amplitude-modulated output signais by generating a carrier frequency signal having a carrier frequency from about 1 KHz to 5000 MHz; and one or more amplitude modulation frequency signais having amplitude modulation frequencies from about 0.1 Hz to about 150,000 Hz, wherein the amplitude modulation frequencies are selected to be cancer-specific frequencies.
[0012] The frequency synthesizer may be a digital frequency synthesizer comprising (i) a digital 20 carrier frequency synthesizer configured to output the carrier frequency signal; (iî) a digital modulation frequency synthesizer configured to output the one or more amplitude modulation frequency signais; (iii) an arithmetic logic unît (ALU) configured to numerically compute one or more digital modulated signais from the carrier frequency signal and a modulation frequency digital signal in real-time; and (iv) a digital to analog converter (DAC) configured to couvert the 25 one or more digital modulated signais to the one or more amplitude-modulated output signais.
[0013] In another aspect, the invention, provides a method of treating a subject suffering from cancer, the method comprising exposing the subject to low energy high frequency radiation, wherein the low energy high frequency radiation comprises one or more amplitude-modulated output signais, wherein the one or more amplitude-modulated output signal(s) hâve a carrier 30 frequency from about 1 KHz to 5000 MHz; and hâve amplitude modulation frequencies from about
0.1 Hz to about 150,000 Hz, and wherein the amplitude modulation frequencies are selected to be cancer-specific frequencies; and wherein the subject is treated with one or more, or 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of cancer-specific amplitude modulation frequencies disclosed herein.
[0014] In another aspect, the devices and methods disclosed herein use a spécifie absorption rate (SAR) of the low energy high frequency radiation absorbed by the patient that is from about 1 microWatt per kilogram of tissue to about 50 Watts per kilogram of (issue, is from about 100 microWatts per kilogram of tissue to about 10 Watts per kilogram of tissue, or îs from about 0.02 milliWatt per kilogram of tissue to about 400 milliWatts per kilogram of tissue. The low energy high frequency radiation may be applied to the subject undergoing treatment via an electrically conductive probe, which may be configured for contact with a mucosa of the subject or with the skin of the subject.
[0015] In another aspect the frequency synthesizer is a digital frequency synthesizer comprising a digital carrier frequency synthesizer configured to output the carrier frequency signal; a digital modulation frequency synthesizer configured to output the one or more amplitude modulation frequency signais; an arithmetic logic unit (ALU) configured to numerically compute one or more digital modulaled signais from the carrier frequency signal and a modulation frequency digital signal in real-time; and a digital to analog converter (DAC) configured to convert the one or more digital modulated signais to the one or more amplitude-modulated output signais.
[0016] The methods and devices disclosed herein may be used for the treatment of a wide varîety of cancers, including breast cancer, neuroendocrine tumors, non-Hodgkin lymphoma, adenocarcinoma, head and neck cancer, gastric cancer, glioblastoma, squamous cell carcinoma, hepatoœllular carcinoma, cholangiocarcinoma, mesothelioma, thyroid cancer, prostate cancer, rhabdomyosarcoma, lung cancer, kidney cancer, ovarian cancer, bladder cancer, leiomyosarcoma, myeloma, lymphoma, leukemîa, chronîc lymphoid cancer, brain cancer, and colorectal cancer.
BRIEF DESCRIPTION OF THE DRAWINGS
J’
[0017] FIG. 1 shows an example System for application of a low energy electromagnetîc radiation to a subject.
[0018] FIG. 2 illustrâtes a block diagram of an example émission device for application of a low energy electromagnetic radiation to a subject.
[0019] FIG. 3 illustrâtes a block diagram of an example digital frequency synthesizer of the émission device of FIG. 2.
[0020] FIG. 4 illustrâtes a block diagram of a controller of the émission device of FIG. 2.
[0021] FIG. 5 illustrâtes an example amplitude-modulated output signal.
[0022] FIG. 6 illustrâtes a block diagram of internai hardware included in any of the electronic components of the émission device of FIG. 2.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0023] As used in this document, the sîngular forms “a,” “an,” and “the” include plural references unless the context clearly dictâtes otherwise. Unless defined otherwise, ail technical and scientific terms used herein hâve the same meanings as commonly understood by one of ordinary skill in the art. As used in this document, the term “comprising” (or “comprises”) means “including 15 (or includes), but not limited to.” When used in this document, the term “exemplary” is intended to mean “by way of example” and is not intended to indicate that a particular exemplary item is preferred or required.
[0024] In this document, when terms such “first” and “second” are used to modify a noua or phrase, such use is simply intended to distinguish one item from another, and is not intended to 20 require a sequential order unless specifically stated. The term “about” when used in connection with a numerîc value, is intended to include values that are close to, but not exactly, the number. For example, in some embodiments, the tenu “about” may include values that are within +/- 10 percent of the value.
[0025] The présent disclosure relates generally to a method and apparatus for using low energy 25 émission therapy, which involves application of low energy radio frequency (RF) electromagnetic fields to a warm-blooded mammalian subject for the treatment of various forms of cancer, using particular frequencies of radio frequency (RF) radiation. The disclosures of EP 0 592 851 B1 and U.S. Pat. No. 8,977,365 (“the ‘365 patent”) are incorporated herein in entirety by reference.
[0026] Terminology that is relevant to this document includes:
[0027] An electronic device” or a “computing device” refers to a device or system that includes a processor and memory. Each device may hâve its own processor and/or memory, or the processor and/or memory may be shared with other devices as in a Virtual machine or container arrangement. The memory will contain or receive programming instructions that, when executed by the processor, cause the electronic device to perform one or more operations according to the programming instructions. Examples of electronic devices include personal computers, servers, mainframes, Virtual machines, containers, gaming Systems, télévisions, digital home assistants and mobile electronic devices such as smartphones, fitness tracking devices, and wearable Virtual reality devices. Electronic devices also may include Internet-connected wearables such as Smart watches, Smart clothing and smart eyewear. Electronic devices also may be embedded in products that are designed to be used by a human during treatment, such as a spoon shaped probe, and may be connected to a subject by any means that provides an adéquate transmission of the frequencies to the subject, including but not limited to devices in direct contact with a mucosa of a subject such as a spoon shaped or other shaped probe, devices in contact with the subject’s skin such as a band or patch or a means to transmit the frequencies without direct contact with the subject. In a clientserver arrangement, the client device and the server are electronic devices, in which the server contains instructions and/or data that the client device accesses via one or more communications links in one or more communications networks. In a virtual machine arrangement, a server may be an electronic device, and each virtual machine or container also may be considered an electronic device. In the discussion below, a client device, server device, virtual machine or container may be referred to sîmply as a “device” for brevity. Additional éléments that may be included in electronic devices will be discussed below in the context of FIG. 6.
[0028] The terms “processor” and “processing device” refer to a hardware component of an electronic device that is configured to execute programming instructions. Except where specifically stated otherwise, the singular ternis “processor” and “processing device” are intended lo include both singie-processing device embodiments and embodiments in which multiple processing devices together or collectively perform a process.
[0029] The terms “memory,” “memory device,” “data store,” “data storage facility” and the like each refer lo a non-transitory device on which computer-readable data, programming instructions or both are stored. Except where specifically stated otherwise, the terms “memory,” “memory device, “data store, ‘data storage facility” and the like are intended to include single device embodiments, embodiments în which multiple memory devices together or collectively store a set of data or instructions, as well as individual sectors within such devices.
[0030] As used herein, the term “treat”, “treating” or “stimulating” refers to any process, action, application, therapy, or the like, wherein a subject (or patient), including a human being, is provided medical aid with the object of improving the subject's condition, directly or indirectly, or slowing the progression of a condition or disorder in the subject, or ameliorating at least one symptom of the disease or disorder under treatment.
[0031] The term patient or subject, as used herein, refers to any animal, preferably a mammal, and more preferably a human, and includes, but is not limiled to, domestic and farm animais, primates, and humans, for example, human beings, non-human primates, cows, horses, pigs, sheep, goats, dogs, cals, or rodents like rats and mice.
[0032] The device and method of the invention provide treatrnents of disease States in a patient, and particularly of cancer types, by the application to the patient of particular and disease-specific low energy high frequency radiation. The device uses a high précision frequency synthesizer to generate radio frequency EMF that is amplîtude-modulated at îdentified tumor-specific frequencies for application to the patient during therapy.
[0033] The System of the current disclosure is employed to influence cellular functions or malfunctions in a warm-blooded mammalian subject. The System comprises one or more controllable low energy electromagnetic energy generator circuits for gencrating one or more radio frequency output signais. One or more controller circuits comprising or communicating with the one or more generator circuits are provided, which are also for receiving control information from a source of programmed control information. The one or more generator circuits may include a programmable field-programmable gâte array (FPGA) configured for digital synthesis of a complété modulated digital signal using one or more direct digital synthesizers (DDS). FPGA generates the modulated digital signal by numerical computation based on a carrier frequency digital signal and a modulation frequency digital signal. The complété modulated digital signal generated by the FPGA is, in terms of an important improvement of the présent invention, preferably adapted to accurately control lhe frequency of the amplitude modulations to within an accuracy of 1 part per 10,000, more preferably within an accuracy of 1 part per 100,000 and most •
preferably within an accuracy of 1 parts per million (ppm), with a long term stability of +/-5.3 ppm, relative to one or more determîned or predetermined reference amplitude modulation frequencies selected from within a range of 0.1 Hz to 150,000 Hz, more preferably within 100 Hz to 99,000 Hz. The FPGA synthesis of complété modulated digital signal also allows for other 5 types of modulation and combination of different modulation frequencies simultaneously.
Moreover, such a digital synthesis also allows the resolution to be independent of the aclual modulation frequency. The complété modulated digital signal may be converted to an analog RF output signal using a suitable digital to analog (DAC) converter. The system furthermore comprises a connection or coupling position for connection or coupling to or being connected or 10 coupled to an electrically conductive applicator for applying to the warm-blooded mammalian subject the one or more amplitude-modulated low energy émissions at said accurately controlled modulation frequencies.
[0034] While the current disclosure describes the use of modulated digital signais, analog form and analog modulation signais may also be used, as described in the ‘365 patent.
[0035] As used herein, the term, “accurately controlled” means that the modulated low energy electromagnetic émissions preferably shouid be modulated to within a resolution of at most about 0.1 Hz, more preferably, about 0.05 Hz, most preferably about 3 to about 5 milli Hz (0.003-0.005 Hz) of intended determîned or predetermined modulation frequencies. For example, if one of the one or more determîned or predetermined modulation frequencies to be applied to the warm20 blooded mammalian subject is about 2000 Hz, the accurate control shouid lead to such modulated low energy émission being generated at a frequency of between about 1999.995 — 1999.997 and about 2000.003 - 2000.005 Hz.
[0036] Of importance is the condition for émissions to be at a very low and safe energy level and resuit in low levels of absorption. The reason believed to be that physiological exchanges or 25 flow of electrical impulses within warm-blooded animais (which are to be affected by application of the émissions of the présent invention) are similarly at very low energy levels. In any event, in the région (at or near to the position of contact or close-by induction of the electrically conductive applicator with a subject receiving treatment), the spécifie absorption rate (SAR) shouid be between about 0.02 and about 400 milliW/kg.
[0037] Furthermore of importance to achieve the intended biological therapeutic effect is that the stabîlity of the émissions be maintained durîng émission, and that such stability should preferably be at least about 105, more preferably at least about 10’fi, and most preferably at least about 10‘7, stability being determined as the relative déviation of frequency divîded by the desired frequency, e.g., 0.01 Hz (deviation)/l,000 Hz (desired freq.)=10-5.
[0038] Referring now to FIG. 1, a System 100 for treatment of cancer in a subject may include an émission device 101 in communication with a subject 110. The émission device 101 may be configured to provide a modulated RF electromagnetic radiation (hereinafter “output signal”) at desired frequencies to the subject 110 via a probe 102. In certain embodiments, the output signal has various control parameters such as, without limitation, duration of a session, sequence of applied frequencies in a session, and duration of each applied frequency. The applied frequencies and their corresponding duration may be determined based on the type of tumor being heated. Specifically, the sélection of such output signais is based on output signais predetermined to provide bénéficiai therapeutic effects in multiple subjects or patients pre-diagnosed with an identified poor health condition. The above-mentioned output signais may be provided by the émission device 101 adapted to generate EMF output signais at certain predetermined modulation frequencies. Different types of modulation may be used such as, without limitation, amplitude modulation, frequency modulation, and phase modulation. Preferably, the output signais are generated at tumor-specific amplitude modulation (AM) frequencies.
[0039] In certain embodiments, the probe 102 may be an electrically conductive applicator for applying one or more electromagnetic émissions to the warm-blooded mammalian subject via, for example, a conductive, inductive, capacitive, radiated coupling, or combinations thereof. One form of applicator may comprise an electrically conductive probe, for example, a mouthpiece which is inserted into the mouth of a subject undergoing treatment. The probe may be adapted for application to any mucosa of the subject (such as by being located within oral, nasal, optical, uréthral, anal, and/or vaginal cavities or surfaces), adapted for physical contact with the skin of the patient (e.g., an insulated probe in contact with the ears, head, neck, etc. of a subject), or any other means.
[0040] In other embodiments, the EMF output signais are applied to the subject through an antenna which is not in direct physical contact with the subject. In such embodiments, the subject may be in a chamber exposed to the EMF output signais or the subject may be kept in proximity to the broadcasting antenna for the EMF output signais during the duration of the treatment(s). [0041] The probe 102 may be connected to the émission device 101 through, for example, a coaxial cable 104.
[0042] Referring now to FIG. 2, a block diagram illustrating an example émission device 101 is shown. As shown in FIG. 2, the émission device 101 includes a controller 201, a memory 202, an oscillator 203, a digital frequency synthesizer 204, a digital-to-analog (DAC) converter 205, an amplifier 206, a filter 207, a directional coupler 208, impédance transformer 209, a power source 210, and a communications interface 211. Optionally, the émission device 101 may also include a 10 display 212, a user interface 213, and other output component(s) 214 (e.g., LEDs, speaker, etc.).
[0043] In certain embodiments, the controller 201 may ope rate as a controller for the émission device 101 to control one or more operations of one or more components of the émission device 101. The controller 201 may be communîcatively coupled to various components of the émission device 101 via, for example, an address bus, a data bus, and input/output lines, or the like (not 15 shown here). The timîng for the controller 201 may be provided by a System clock (not shown here) that runs at any suitable clock frequency for the type of processor. In general, controller 201 is configured to control one or more operations of one or more components of the émission device 101 to produce a desîred form of modulated low energy electromagnetic émission for application to a subject through probe 102.
[0044] The levei of power applied is preferably controlled by the controller 201 to cause the spécifie absorption rate (SAR) of energy absorbed by the patient to be from about 1 micro Watt per kilogram of tissue to about 50 Watts per kilogram of tissue. Preferably, the power level is controlled to cause an SAR of from about 100 microWatts per kilogram of tissue to about 10 Watts per kilogram of tissue. Most preferably, the power level is controlled to cause an SAR of from 25 about 0.02 milliWatt per kilogram of tissue to about 400 milliWatts per kilogram of tissue. These SARs may be in any tissue of the patient.
[0045] The frequencies of electromagnetic radiation may be tumor-specific and are described below in more detail.
[0046] Referring now to FIG. 4, a typical controller 400 is shown with a processor 402, Random 30 Access Memory (RAM) 403, nonvolatile memory 404, device spécifie circuits 401, and input output (I/O) interface 405. Alternative!y, the RAM 403 and/or nonvolatile memory 404 may be contained in the processor 402 as could the device spécifie circuits 401 and I/O interface 405. The processor 402 may comprise, for example, an off-the-shelf microprocessor, custom processor, Field Programmable Gâte Array (FPGA), Application Spécifie Integrated Circuit (ASIC), discrète iogic, etc. The RAM 403 is typically used to hold variable data, stack data, exécutable instructions, etc.
[0047] According to various approaches, the nonvolatile memory 404 may comprise any type of nonvolatile memory such as, but not limited to, Electrically Erasable Programmable Read Only Memory (EEPROM), flash Programmable Read Only Memory (PROM), battery backup RAM, hard disk drives, etc. However, the nonvolatile memory 404 is typically used to hold the exécutable fîrmware and any nonvolatile data containing programmîng instructions that can be executed to cause the processor 402 to perform certain functions.
[0048] In some embodiments, the I/O interface 405 may include a communication interface that allows the processor 402 to communicate with devices external to the controller. Examples of the communication interface may comprise, but are not limited to, serial interfaces such as RS-232, USB (Universal Serial Bus), Small Computer Systems Interface (SCSI), Ethernet, RS-422 or a wireless communication interface such as Wi-Fi, Bluetooth, near-field communication (NFC) or other wireless interfaces. The controller 400 may communicate with an external device via the communication interface 405 in any communication protocols such as Automation/Drive Interface (ADI).
[0049] According to various approaches described and/or suggested herein, a controller may hâve a single processor or controller, or it may include multiple processors or controllers, or multiple cores in a processor chip.
[0050] The memory 202 may be any storage device capable of storing information for later retrieval, and may be configured to store data for the operation of the émission device 101. For example, memory 202 may be a magnetic media based storage device (such as a card, tape, disk, or drum), a semiconductor memory-based storage device (such as an erasable programmable read only memory (EPROM), an electrical erasable programmable read only memory (EEPROM) or a non-volatile random access memory (RAM)), a mechanical information storage device (such as a •
punched card, cam, or the like), and/or an optical storage device (such as a compact disk read only memory (CD ROM)).
[0051] The memory 202 may include control information that spécifiés various controllable parameters (to be used by the controller 201) of the modulated low energy radiation to be applied 5 to a subject through probe 102. Such controllable parameters include, for example, but are not necessarily limited to, the frequency and amplitude of the output signal, the duration of the émission, the power level of the émission, the duty cycle of the émission (i.e., the ratio of on time to off time of pulsed émissions applied during a treatment), the sequence of application of different modulation frequencies for a particular application, and the total number of treatments and 10 duration of each treatment prescribed for a particular subject, and combinations thereof.
[0052] For example, FIG. 5 illustrâtes an example amplitude-modulated output signal that may be applied to a subject in a sequence of application of different modulation frequencies, ranging from the lowest frequency to the highest frequency, with each modulation frequency applied for a predetermined time duration. As discussed above, while the current disclosure describes the use 15 of digitals signais (carrier frequency signal and/or modulation frequency signal), use of analog signais for generating the modulation frequencies of this disclosure are within the scope of this disclosure. Methods and Systems for génération of analog signais is described in the ‘365 patent.
[0053] In certain embodiments, the carrier frequency digital signal and the modulation frequency digital signal (described below) may be selected to drive the probe 102 with an amplitude20 modulated output signal. The carrier frequency digital signal may be from about 1 KHz to 5000
MHz, or from about 0.1 - 1000 MHz, or from about 1-500 MHz, or from about 1-100 MHz, or from about 5-50 MHz, or from about 10 MHz to about 40 MHz, or from about 15 MHz to about 30 MHz, or any other frequency that is capable of leveraging a subject’s body as an antenna (e.g., 27 MHz). The one or more modulation frequencies may be simultaneously emitted or sequenced 25 to form the modulation signal. The modulation frequency digital signal may be about 0.1 Hz to 150,000 Hz, more preferably within 100 Hz to 99,000 Hz, and may be determined and selected based on the type of dîsease State or cancer to be treated (as described below).
[0054] In certain embodiments, the memory 202 may also store event data, user information (e.g., authenticalion data, medical information, etc.), troubleshooting instructions, or the like, 30 correspondîng to the émission device 101. Examples of event data may include, without limitation, error logs, use history and associated data, treatment information, battery information, etc. Such event data may be used to monitor patient compliance, detect problems with the functîons and the handling of the device, or the like. The information or data stored in the memory 202 may be retrieved using the communications interface 211 directly and/or indirectly (e.g., via a docking station for charging the émission device 101). Such information may then be used by a physician or other clinician to assess patient treatment compliance and effect. Treatment information may include, for example; the number of treatments applied for a given time period; the actual time and date of each treatment; the number of attempted treatments; the treatment compliance (i.e., whether the probe was in place or not in place during the treatment session); and the cumulative dose of a particular modulation frequency.
[0055] The digital frequency synthesîzer 204 may be a programmable logic device (PLD) such as a fîeld programmable gâte array (FPGA), and may be configured to provide digital synthesis of a complété modulated output signal. Those skilled in the art will apprecîate that the digital synthesis implémentations could be comparably used when implemented on other PLDs. FIG. 3 illustrâtes a block diagram of an example digital frequency synthesîzer 204.
[0056] As shown in FIG. 3, the digital frequency synthesîzer 204 may include a carrier frequency direct digital synthesîzer (DDS) 301, a modulation frequency DDS 302, one or more control registers 303, a phase-locked loop (PLL) frequency multiplier 304, and an arithmetic logic unit (ALU) 305.
[0057] Direct digital synthesis (DDS) is an increasîngly popular technique for the génération of radio frequency (RF) signais due to its high performance and low cost. A DDS créâtes RF signais by using a reference clock supplied from an external source and data programmed into registers of the DDS. The DDS uses the reference ciock to create an internai System clock as a multiple of the reference clock. The DDS uses the System clock to read the data programmed into the registers to create a digital signal output. The DDS also generates a synchronization clock to be used by external hardware to synchronize external hardware with the internai System clock of the DDS. The carrier frequency DDS 301 and the modulation frequency DDS 302 may include a core architecture consisting of a phase accumulator, which uses the data programmed into control registers 303 to set the output frequency and phase offset, and a phase to amplitude sine or cosine lookup table at the output éliminâtes high frequency sampling images to output a pure sine wave •
digital signal. In certain embodiments, carrier frequency DDS 301 may be an M-bit DDS (e.g., a 32-bit sinus DDS), and the modulation frequency DDS 302 may be an N-bit DDS (e.g., a 32-bit sinus DDS). Digital signal forms that hâve been successfully employed include square wave forms, sinusoïdal wave forms, rectified sinusoïdal, triangular, or other wave forms and/or combinations 5 thereof.
[0058] The control registers 303 may receive data and/or instructions for setting the output frequency and phase offset of the output digital signais from the controller 201.
[0059] The carrier frequency DDS 301 may generate an M-bit carrier frequency digital signal, and the modulation frequency DDS 302 may generate an N-bit modulation frequency digital 10 signal. The N-bit modulation frequency digital signal may be modified to control the modulation factor of the modulation frequency digital signal before being input into the ALU 305. In an embodiment, the ALU 305 may numerîcally compute a modulated digital output signal from the carrier frequency digital signal and the modulation frequency digital signal in real-time. For example, the digital frequency synthesizer 204 may output a K-bit (e.g., 12-bit) parallel modulated 15 digital output signal. It should be noted the ALU 305 may be configured to numerîcally compute a digital output signal for providing amplitude modulation, frequency modulation, and/or phase modulation.
[0060] The modulated digital output signal may optionally undergo further amplitude modulation in a digital multiplier (not shown here) before conversion to an analog RF output.
[0061] The digital frequency synthesizer 204 also includes a PLL frequency multiplier configured to generate the internai System clock for the carrier frequency DDS 301 and the modulation frequency DDS 302, using a reference clock generated by a clock oscïllator 203. The clock oscillator 203 may be a précision température compensated crystal oscïllator with an initial accuracy of +/- 1 ppm. In an exemplary embodiment, the internai System clock may be set to 128
MHz and reference clock may be set to 16 MHz.
[0062] It should be noted that while FIG. 3 illustrâtes one modulation frequency DDS 302, the disclosure is not so limîting, and the digital frequency synthesizer may include one or more modulation frequency generators to allow for transmitting multiple modulation frequency digital signais simultaneousiy.
[0063] Referring back to FIG. 2, the modulated digital output signal from the digital frequency synthesizer 204 may be input into DAC converter 205 to generate an analog RF signal. The RF signal from the DAC converter 205 passes through an amplifier 206 (e.g., a linear RF power amplifier in bridge configuration), an optional transformer (e.g., a balun) (not shown here), a fi lier 5 circuit 207 (e.g., a 5,h order elliptic cauer fîlter), followed by output to the probe 102. The filter circuit 207 may be connected to probe 102 via a coaxial cable 104 and impédance transformer 209 (configured to substantîally match the impédance of the subject with the impédance of the output of the émission device 101. It has been determined through impédance measurements that when probe 102 is applied to the mouth of a patient, the probe/patient combination exhibits a complex 10 impédance on the order of 150+jaoo Ohms. Impédance transformer 209 serves to match this complex impédance with the impédance of coaxial cable, and therefore the output impédance of the fîlter circuit 207. This promûtes power transmission, and minimizes reflections. In a further example, a conductive, isolated probe 102 has been used at a frequency around 433 MHz couplîng to the outer ear channel. Due to the different probe design in such a frequency band and with this 15 coupling method, the values of matching éléments would be different or could even be omitted.
Probe 102 may then be regarded as a capacitive coupler or as an antenna matched to the capacitive load.
[0064] In certain embodiments, the output from the filter circuit 207 may pass through a directional coupler 208. The output signais from the directional coupler 208 may be fed into two 20 ADC inputs of the controller 201, where the amplitude and the ratio of the two signais allow the controller 201 to continuously monitor both the output power/frequency of the signal in the probe 102 and the quality of the probe's contact to the subject. This information may be used by the controller 201 to détermine whether electromagnetic émissions at the desired frequency and power are présent. Controller 201 then takes appropriate action, for example, display an error message 25 on display 212, provide appropriate corrective signais to one or more components of the émission device 101, détermine and control the amount of power applied to the subject, assess patient treatment compliance, record indicia of the patient treatment compliance on memory 202 for later . analysis and assessment by a physician or other clinician.
[0065] The directional coupler 208 may operate to couple a portion of the energy emitted by 30 filter circuit 207 through an output connector into detecting circuits. The output connecter is connected to a primary input of the direclional coupler, and co-axial cable is connected to a primary output of directional coupler. Direction coupler includes two secondary outputs, each of which is connected to a detecting circuit. First detecting circuit functions to detect the amount of power applied to the patient, and second detecting circuit functions to detect the amount of power reflected from the patient. First detecting circuit is connected through a résistive divider to the positive input of a differential amplifier. Second detecting circuit is connected through the résistive divîder to the négative input of differential amplifier. The output of differential amplifier is indicative of the différence between the power transmitted to the patient by filter circuit, and the power reflected from the patient, and thus is indicative of an amount of power absorbed by the patient. The output of differential amplifier is applied to an analog to digital converter (ADC) or comparator, the output of which connected to controller 201.
[0066] The fully digital synthesis of the modulated digital signal in the digital frequency synthesizer 204 combined with the linear output stage allows for modulation of the applied radiation using other modulation types in addition to amplitude modulation.
[0067] The émission device 101 may also include a power source 210 for supplying power to one or more components of the émission device 101. The power source 210 may be an energy storage system like a battery, a super capacîtor, lithium ion cell, fuel cell or another energy storage. The power source 210 may be recharged using direct or inductive cbarging from a power source such as an AC power outlet, a docking station, or the like. In certain embodiments, the controller 201 may monîtor the power level of the power source 210, and may provide an alert to a user when the power level reaches a threshold level. In addition, the controller 201 may perform actions such as switch off (and/or initiate low power mode) the émission device 101, or one or more of its components of the émission device 101 based on the power level.
[0068] Optionally, a docking station may be included in the System (not shown here) configured to recharge the power source 210. The docking station may include components such as a communications interface, a user authentication module, an activation module (for actîvating the émission device 101, or any other now or hereafter known components.
[0069] The émission device 101 may also include a communications interface 211 that allows the controller 201 to communicate with devices external to the émission device 101 such as a server, an electronic device, a docking station, etc. Examples of the communication interfaces may comprise, but are not limited to, serial interfaces such as RS-232, Universal Serial Bus (USB), Small Computer Systems Interface (SCSI), Ethernet, RS-422 or a wireless communication interface such as Wi-Fi, Bluetooth, near-field communication (NFC) or other wireless interfaces. The controller 201 may communicate with an external device via the communication interface 211 in any communication protocols such as Automation/Drive Interface (ADI).
[0070] As discussed above, the émission device 101 may also include optional components such as a display 212 (which can display various indications/alerts of the operation of émission device 101), a user interface 213 (e.g., a keyboard, microphone, touch interface, etc. configured to user instructions), and other output component(s) 214 (e.g., LEDs, speakers, or the like).
[0071] In certain embodiments, the émission device 101 may include an activation module (not shown here) for activating the émission device 101 for a partîcuiar treatment session. The treatment session may be user spécifie and determined based on authentication information received from a user. For exaniple, the treatment session may be actîvated for a user depending upon the disease state of the user. Various parameters of a treatment session may include, without limitation, the total duration of the émission for a treatment session, the power level of the émission, the duty cycle of the émission (i.e., the ratio of on time to off time of pulsed émissions applied during a treatment), the sequence of application of different modulation frequencies for a particular application, and the total number of treatments and duration of each treatment prescribed for a particular subject, and combinations thereof.
[0072] The activation module may receive authentication information from a user, via for example, the user interface (e.g., fingerprint, retina scan, login credentials, etc.), an activation card (e.g., an RFID chip card, an ISO chip card, a contact less (NFC) card, etc.) in communication with an activation interface of the émission device 101 and/or an external device in communication with the émission device 101 such as the docking station.
[0073] The controller 201 of the émission device 101 may operate to analyze the information provided by the directional coupler to détermine and control the amount of power applied to the patient, to assess patient treatment compliance, and to possibly to record indicia of the patient treatment compliance on memory 202 for iater analysis and assessment by a physician or other clinîcian.
[0074] Exemplary of treatments performed on patients hâve included brain, bladder, colorectal, kidney, mésothélium, neuroendocrine, liver, biliary tract, lung, breast, ovary, pancréas, prostate and thyroid tumor types. The treatments involved applying carrier signal, amplitude-modulated at specifïcally defined frequencies ranging from about 0.1 to about 150,000 Hz at very high précision and stability. The carrier signal may be from about 1 KHz to 5000 MHz, or from about 0.1 -1000 MHz, or from about 1-500 MHz, or from about 1-100 MHz, or from about 5-50 MHz, or from about 10 MHz to about 40 MHz, or from about 15 MHz to about 30 MHz, or any other frequency that is capable of leveraging a subject’s body as an antenna (e.g., 27 MHz). The one or more modulation frequencies may be simultaneously emitled or sequenced to form the modulation signal. The modulation frequency digital signal may be about 0.1 Hz to about 150,000 Hz, more preferably within about 100 Hz to about 99,000 Hz. The one or more modulation frequencies may be determined and selected based on the type of disease state or cancer to be treated. Further examples of treatment modes (at spécifie accurately controüed AM frequencies) for specified types of tumors are described in detail below.
[0075] FIG. 6 depîcts an example of internai hardware thaï may be included in any of the electronic components of the émission device 101. An electrical bus 600 serves as an information highway interconnecting the other illustrated components of the hardware. Processor 605 is a central processing device of the System, configured to perform calculations and logic operations required to execute programming instructions. As used in this document and in the claims, the terms “processor” and “processing device” may refer to a single processor or any number of processors in a set of processors that collectively perform a set of operations, such as a central processing unit (CPU), a graphies processing unit (GPU), a remote server, or a combination of these. Read only memory (ROM), random access memory (RAM), flash memory, hard drives and other devices capable of storing electronic data constitute examples of memory devices 625. A memory device may include a single device or a collection of devices across which data and/or instructions are stored.
[0076] An optional display interface 630 may permit information from the bus 600 to be displayed on a display device 635 in Visual, graphie or alphanumeric format. An audio interface and audio output (such as a speaker) also may be provided. Communication with external devices may occur using various communication devices 640 such as a wireless antenna, an RFID tag and/or short-range or near-neld communication transceiver, each of which may optionally communicatively connect with other components of the device via one or more communication System. The communication device 640 may be configured to be communicatively connected to a communications network, such as the Internet, a local area network or a cellular téléphoné data network.
[0077] The hardware may also include a user interface sensor 645 that allows for receipt of data from input devices 650 such as a keyboard, a mouse, a joystick, a touchscreen, a touch pad, a remote control, a poînting device and/or microphone. Digital image frames also may be receîved from a caméra 620 that can capture video and/or still images. The hardware may also include one or more sensors 660 such as position sensors (global positioning Systems), température sensors, puise rate sensors, heart pressure monitors, résistance sensors, or the like.
[0078] Frequencies that are effective for treatment of a particular disease state or cancer may be discovered using any now or hereafter known methods. Frequency dîscovery may include exposing one or more subjects pre-diagnosed with a particular health condition (for example, a particular cancer type) to précisé modulation frequencies that are applied to the subject or subjects and measuring variations in one or more physiological responses of the patient(s). The frequencies determined in this manner may also be screened against healthy subjects to détermine diseasespecific modulation frequencies. Control measurements may be obtained by exposing one or more subjects that do not suffer from a particular health condition (for example, a particular cancer type) to modulation frequencies that are applied to the subject or subjects and measuring variations in one or more physiological responses of the patîent(s). For example, frequency dîscovery may include measuring variations in skin electrical résistance, puise amplitude and/or blood pressure of a subject while being exposed to modulation frequencies generated using the methods and Systems disclosed herein. For frequency dîscovery, the subject may be exposed to modulation frequencies from about 0.1 Hz to about 150,000 Hz incrementally (e.g., using incréments of about 50 Hz to about 150 Hz, preferably about 75 Hz to about 125 Hz), and variations in skin electrical résistance, puise amplitude and/or blood pressure may be measured. Whencver a change is observed in the measured skin electrical résistance (threshold change), puise amplitude (for about 1-2 beats), and/or blood pressure (threshold change), exposure to the corresponding modulation frequencies may be repeated using încreasingly smaller incréments (e.g., 10'4 - 10'3 Hz).
Frequencies eliciting the best biofeedback responses are selected as tumor-specific frequencies. For example, if the variations in the amplitude of the puise are used, best biofeedback responses may be definedby the magnitude of increased amplitude and/or the number of beats with increased amplitude. Such frequency détection may be performed in subjects at different disease stages: 5 disease progression, stable disease and/or partial response. The sélection of spécifie frequencies may be performed according to the method described in Barbault et al. 2009 J. Exp. Clin. Cancer Res. 28(1): 51.
[0079] Using the above methods, it has been determined that the methods and Systems of this disclosure provide a safe and promising novel treatment modality for multiple types of cancer such 10 as, without limitation, breast cancer, pancreatic cancer, non-small cell and small cell lung cancer, neuroendocrine tumors, non-Hodgkin lymphoma, adenocarcinoma, head and neck cancer, gastric cancer, glioblastoma, squamous cell carcinoma, hepatoceilular carcinoma, cholangiocarcinoma, mesothelioma, thyroid cancer, prostate cancer, rhabdomyosarcoma, multiple myeloma, leukemia, and colorectal cancer.
[0080] Amplitude-modulated frequencies discovered to be effective in treatment of different types of cancer are listed below. In general, it may be preferred that ail frequencies determined to be spécifie to a particular cancer-type be applied în the treatment of subjects suffering from the indicated form of cancer. However, a limited number of the determined frequencies also leads to bénéficiai effects, for example 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 20 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of the listed frequencies.
Table A
262-262.7 Hz 266.3-267 Hz 295-295.6 Hz 334-334.7 Hz
374-374.7 Hz 408-408.7 Hz 415-415.7 Hz 418-418.7 Hz
419.8-420.4 Hz 420-420.7 Hz 420.4-420.8 Hz 429-429.7 Hz
429.7-430.3 Hz 439-439.7 Hz 441-441.7 Hz 442-442.7 Hz
465-465.7 Hz 485-485.7 Hz 527-527.7 Hz 556-556.7 Hz
561-561.7 Hz 568-568.7 Hz 572-572.7 Hz 581-581.7 Hz
594-594.7 Hz 605-605.7 Hz 611-611.7 Hz 612-612.7 Hz
624.32-624.8 Hz 626-626.7 Hz 627-627.7 Hz 631-631.7 Hz
633-633.7 Hz 638-638.7 Hz 677.4-678 Hz 679-679.7 Hz
709-709.7 Hz 717-717.7 Hz 727-727.7 Hz 733-733.7 Hz
737-737.7 Hz 759-759.7 Hz 761-761.7 Hz 810-810.7 Hz
811-811.7 Hz 817-817.7 Hz 826-826.7 Hz 829-829.7 Hz
830-830.7 Hz 834-834.7 Hz 836-836.7 Hz 883-883.7 Hz
959-959.7 Hz 961-961.7 Hz 963.8-964.25 Hz 964.5-965 Hz
966-966.7 Hz 969-969.7 Hz 972-972.7 Hz 974.4-975 Hz
977-977.7 Hz 996-996.7 Hz 1027-1027.7 Hz 1045-1045.7 Hz
1157-1157.7 Hz 1179.2-1179.8Hz 1195-1195.7 Hz 1213-1213.7 Hz
1220-1220.7 Hz 1252-1252.7 Hz 1314-1314.7 Hz 1336-1336.7 Hz
1352-1352.7 Hz 1369-1369.7 Hz 1436-1436.7 Hz 1467-1467.7 Hz
1622-1622.7 Hz 1652-1652.7 Hz 1668-1668.7 Hz 1728-1728.7 Hz
1759-1759.7 Hz 1771.7-1772.3 Hz 1772.3-1772.8 Hz 1785-1785.7 Hz
1808-1808.6 Hz 1815-1815.7 Hz 1823-1823.7 Hz 1858-1858.7 Hz
1868-1868.7 Hz 1881-1881.7 Hz 1897-1897.7 Hz 1903-1903.7 Hz
1914-1914.7 Hz 1928-1928.7 Hz 1963-1963.7 Hz 1966-1966.7 Hz
1967-1967.7 Hz 1973-1973.7 Hz 1989-1989.7 Hz 2021-2021.7 Hz
2023-2023.7 Hz 2035-2035.7 Hz 2044-2044.7 Hz 2065-2065.7 Hz
2094-2094.7 Hz 2111-2111.7 Hz 2128-2128.7 Hz 2189-2189.7 Hz
2284-2284.7 Hz 2287-2287.7 Hz 2313-2313.7 Hz 2321-2321.7 Hz
2328-2328.7 Hz 2346-2346.7 Hz 2359-2359.7 Hz 2372.3-2372.8 Hz
2373-2373.7 Hz 2380-2380.7 Hz 2429-2429.7 Hz 2439.7-2440.3 Hz
2455-2455.7 Hz 2459-2459.7 Hz 2469.2-2469.7Hz 2483-2483.7 Hz
2513-2513.7 Hz 2518-2518.7 Hz 2612-2612.7 Hz 2627-2627.7 Hz
2629-2629.7 Hz 2632-2632.7 Hz 2636-2636.7 Hz 2647-2647.7 Hz
2648-2648.7 Hz 2653.3-2654 Hz 2653.7-2654.4Hz 2679-2679.7 Hz
2697-2697.7 Hz 2706-2706.7 Hz 2707-2707.7 Hz 2714-2714.7 Hz
2720.3-2721 Hz 2726-2726.7 Hz 2738-2738.7 Hz 2747-2747.7 Hz
2754-2754.7 Hz 2759-2759.7 Hz 2762-2762.7 Hz 2774-2774.7 Hz
2778-2778.7 Hz 2807-2807.7 Hz 2811-2811.7 Hz 2824-2824.7 Hz
2825-2825.7 Hz 2826-2826.7 Hz 2830-2830.7 Hz 2834-2834.7 Hz
2S36-2836.7 Hz 2840-2840.7 Hz 2842-2842.7 Hz 2854-2854.6 Hz
2854-2854.7 Hz 2858.8-2859.35Hz 2860-2860.7 Hz 2864-2864.7 Hz
2865-2865.7 Hz 2878-2878.7 Hz 2890-2890.7 Hz 2893-2893.7 Hz
2940-2940.7 Hz 2971-2971.6 Hz 2975-2975.7 Hz 2981-2981.7 Hz
3030-3030.7 Hz 3056-3056.7 Hz 3085.7-3086.3Hz 3121-3121.7 Hz
3133-3133.7 Hz 3135-3135.7 Hz 3143-3143.7 Hz 3171-3171.7 Hz
3188-3188.7 Hz 3207-3207.7 Hz 3209-3209.7 Hz 3213-3213.7 Hz
3218-3218.7 Hz 3222-3222.7 Hz 3227.3-3228 Hz 3228-3228.7 Hz
3234-3234.7 Hz 3244-3244.7 Hz 3245-3245.7 Hz 3250.3-3250.8Hz
3251-3251.7 Hz 3261-3261.7 Hz 3267-3267.7 Hz 3269-3269.7 Hz
3272-3272.7 Hz 3279.3-3280 Hz 3280.6-3281.3 Hz 3281.6-3282.1 Hz
3322-3322.7 Hz 3360-3360.7 Hz 3371-3371.7 Hz 3428-3428.7 Hz
3446-3446.7 Hz 3466-3466.7 Hz 3522-3522.7 Hz 3529-3529.7 Hz
3537-3537.7 Hz 3548-3548.7 Hz 3556-3556.7 Hz 3562-3562.7 Hz
3571-3571.7 Hz 3595-3595.7 Hz 3609-3609.7 Hz 3618-3618.7 Hz
3621-3621.7 Hz 3622.5-3623 Hz 3627-3627.7 Hz 3630-3630.7 Hz
3631-3631.7 Hz 3633-3633.7 Hz 3634-3634.7 Hz 3637.7-3638.3Hz
3644-3644.7 Hz 3646-3646.7 Hz 3646.4-3647 Hz 3656-3656.7 Hz
3661-3661.7 Hz 3663-3663.7 Hz 3667-3667.7 Hz 3678-3678.7 Hz
3681.7-3682.3Hz 3687-3687.7 Hz 3694-3694.7 Hz 3731-3731.7 Hz
3743-3743.7 Hz 3749.3-3750 Hz 3756-3756.7 Hz 3762-3762.7 Hz
3787-3787.7 Hz 3817-3817.7 Hz 3823-3823.7 Hz 3833-3833.7 Hz
3839-3839.7 Hz 3842.4-3843 Hz 3854-3854.7 Hz 3877-3877.7 Hz
3908.7-3909.22Hz 3910-3910.7 Hz 3915-3915.7 Hz 3922-3922.7 Hz
3936-3936.7 Hz 3940-3940.7 Hz 3946-3946.7 Hz 3947-3947.7 Hz
3948-3948.7 Hz 3954-3954.7 Hz 3958-3958.6 Hz 3962-3962.7 Hz
3981-3981.7 Hz 4007-4007.7 Hz 4013-4013.7 Hz 4027-4027.7 Hz
4048-4048.7 Hz 4055-4055.7 Hz 4135-4135.7 Hz 4148-4148.7 Hz
4152-4152.7 Hz 4155-4155.7 Hz 4190-4190.7 Hz 4198-4198.7 Hz
4224-4224.7 Hz 4233-4233.7 Hz 4249-4249.7 Hz 4281-4281.7 Hz
4283-4283.7 Hz 4323-4323.7 Hz 4368.3-4369 Hz 4386.4-4387 Hz
4409-4409.7 Hz 4410-4410.7 Hz 4418-4418.7 Hz 4425-4425.7 Hz
4430-4430.7 Hz 4425.7-4426.22Hz 4438.7-4439.2 Hz 4441-4441.7 Hz
4459-4459.7 Hz 4465-4465.7 Hz 4476-4476.7 Hz 4477.4-4478 Hz
4523-4523.7 Hz 4548-4548.7 Hz 4580.ll-4580.7Hz 4584-4584.7 Hz
4621-4621.7 Hz 4632-4632.7 Hz 4637-4637.7 Hz 4657-4657.6 Hz
4707-4707.7 Hz 4708-4708.7 Hz 4713-4713.7 Hz 4714-4714.7 Hz
4722-4722.7 Hz 4723-4723.7 Hz 4725-4725.7 Hz 4731-4731.7 Hz
4733-4733.7 Hz 4748-4748.7 Hz 4776-4776.7 Hz 4792-4792.7 Hz
4805.3-4806 Hz 4806-4806.7 Hz 4809-4809.7 Hz 4812-4812.7 Hz
4813-4813.7 Hz 4821-4821.7 Hz 4822-4822.7 Hz 4823-4823.7 Hz
4833-4833.7 Hz 4841-4841.7 Hz 4844-4844.7 Hz 4850-4850.7 Hz
4866-4866.7 Hz 4870-4870.7 Hz 4874-4874.7 Hz 4890-4890.7 Hz
4924-4924.7 Hz 4941-4941.7 Hz 4946-4946.7 Hz 4948-4948.7 Hz
4997-4997.7 Hz 4998-4998.7 Hz 5034-5034.7 Hz 5063-5063.7 Hz
5089-5089.7 Hz 5116-5116.7 Hz 5139-5139.7 Hz 5142-5142.7 Hz
5152-5152.7 Hz 5154-5154.7 Hz 5156-5156.7 Hz 5165.4-5166 Hz
5205-5205.7 Hz 5209-5209.7 Hz 5209.4-5210 Hz 5221-5221.7 Hz
5229-5229.7 Hz 5232-5232.7 Hz 5239-5239.7 Hz 5243-5243.7 Hz
5259-5259.7 Hz 5265-5265.7 Hz 5270-5270.7 Hz 5286-5286.7 Hz
5322-5322.7 Hz 5336-5336.7 Hz 5378.2-5378.7Hz 5407.3-5408 Hz
5414-5414.7 Hz 5424-5424.7 Hz 5427-5427.7 Hz 5438-5438.7 Hz
5484.4-5485 Hz 5510-5510.7 Hz 5533-5533.7 Hz 5618-5618.7 Hz
5640.4-5641 Hz 5671-5671.7 Hz 5714-5714.7 Hz 5716-5716.7 Hz
5741-5741.7 Hz 5742-5742.7 Hz 5752-5752.7 Hz 5766-5766.7 Hz
5881-5881.7 Hz 5884-5884.7 Hz 5976-5976.7 Hz 5996-5996.7 Hz
6010-6010.7 Hz 6024-6024.7 Hz 6058-6058.7 Hz 6070-6070.7 Hz
6074-6074.7 Hz 6094-6094.7 Hz 6112-6112.7 Hz 6117-6117.7 Hz
6159-6159.7 Hz 6167-6167.7 Hz 6179-6179.7 Hz 6220.3-6221 Hz
6252-6252.7 Hz 6297-6297.7 Hz 6298.4-6299 Hz 6317-6317.7 Hz
I 6330-6330.7 Hz 6333-6333.7 Hz 6334-6334.7 Hz 6346-6346.7 Hz
6380.4-6381 Hz 6392-6392.7 Hz 6413-6413.7 Hz 6414-6414.7 Hz
6416.3-6417 Hz 6419.3-6420 Hz 6423-6423.7 Hz 6432-6432.7 Hz
6436-6436.7 Hz 6438-6438.7 Hz 6441-6441.7 Hz 6443-6443.7 Hz
6444-6444.7 Hz 6468-6468.7 Hz 6469-6469.7 Hz 6479.4-6480 Hz
6488-6488.7 Hz 6492.3-6493 Hz 6513-6513.7 Hz 6537-6537.7 Hz
6648-6648.7 Hz 6717-6717.7 Hz 6727.4-6728 Hz 6730-6730.7 Hz
6748-6748.7 Hz 6751-6751.7 Hz 6781-6781.7 Hz 6782-6782.7 Hz
6808-6808.7 Hz 6809-6809.6 Hz 6825-6825.7 Hz 6832-6832.7 Hz
6840-6840.7 Hz 6841-6841.7 Hz 6847-6847.7 Hz 6864-6864.7 Hz
6869-6869.7 Hz 6897-6897.7 Hz 6911.3-6912 Hz 6912-6912.7 Hz
6914-6914.7 Hz 6968.4-6969 Hz 6974-6974.7 Hz 6982-6982.7 Hz
6986-6986.7 Hz 7013-7013.7 Hz 7037-7037.7 Hz 7042-7042.7 Hz
7080-7080.7 Hz 7098-7098.7 Hz 7109-7109.7 Hz 7110-7110.7 Hz
7112-7112.7 Hz 7117-7117.7 Hz 7136-7136.7 Hz 7137-7137.7 Hz
7145.4-7146 Hz 7149-7149.7 Hz 7151-7151.7 Hz 7158-7158.7 Hz
7160-7160.7 Hz 7169-7169.7 Hz 7191.7-7192.3Hz 7222.4-7223 Hz
7225-7225.7 Hz 7234-7234.7 Hz 7239-7239.7 Hz 7246-7246.7 Hz
7253-7253.7 Hz 7268-7268.7 Hz 7274-7274.7 Hz 7283-7283.7 Hz
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44531-44531.7 Hz 44575.3-44576 Hz 44652-44652.7 Hz 44692-44692.7 Hz
44742-44742.7 Hz 44773-44773.7 Hz 44855-44855.7 Hz 44913-44913.7 Hz
45163-45163.7 Hz 45362-45362.7 Hz 45393-45393.7 Hz 45474-45474.7 Hz
45490-45490.7 Hz 45526-45526.7 Hz 46112-46112.7 Hz 46143-46143.7 Hz
46282-46282.7 Hz 46285-46285.7 Hz 46340-46340.7 Hz 46662-46662.7 Hz
46666-46666.7 Hz 46672.3-46673 Hz 46673-46673.7 Hz 46689-46689.6 Hz
46746-46746.7 Hz 46793-46793.7 Hz 47036-47036.7 Hz 47297-47297.7 Hz
47693.4-47694 Hz 48103-48103.7 Hz 48173-48173.7 Hz 48204-48204.7 Hz
48314-48314.7 Hz 48535-48535.7 Hz 48583-48583.7 Hz 48653-48653.7 Hz
48683-48683.7 Hz 48793-48793.7 Hz 49434-49434.7 Hz 50072-50072.7 Hz
50229-50229.7 Hz 50243-50243.7 Hz 50254-50254.7 Hz 50292-50292.7 Hz
51008-51008.7 Hz 51592-51592.7 Hz 51946-51946.7 Hz 52063-52063.7 Hz
52097-52097.7 Hz 52752-52752.7 Hz 52786-52786.7 Hz 52812-52812.7 Hz
52912-52912.7 Hz 53079-53079.7 Hz 53947-53947.7 Hz 54293-54293.7 Hz
54297-54297.7 Hz 55072-55072.7 Hz 55592-55592.7 Hz 55723-55723.7 Hz
56093-56093.7 Hz 57927-57927.7 Hz 58094-58094.7 Hz 59089-59089.7 Hz
59288-59288.7 Hz 59907-59907.7 Hz 59997-59997.7 Hz 61287-61287.7 Hz
61789-61789.7 Hz 65586-65586.7 Hz 66553-66553.7 Hz 66969-66969.7 Hz
67683-67683.7 Hz 67697-67697.6 Hz 69481-69481.7 Hz 71204-71204.7 Hz
71447-71447.7 Hz 71635-71635.7 Hz 74017-74017.7 Hz 76227-76227.7 Hz
76537-76537.7 Hz 76659-76659.7 Hz 78229-78229.7 Hz 78477.4-78478 Hz
79658-79658.7 Hz 79867-79867.7 Hz 80715-80715.7 Hz 80993.3-80994 Hz
81999-81999.7 Hz 82024-82024.7 Hz 82845-82845.7 Hz 83612-83612.7 Hz
84086-84086.7 Hz 85810-85810.7 Hz 86521-86521.7 Hz 87507-87507.7 Hz
87798.3-87799 Hz 88281-88281.7 Hz 88898-88898.7 Hz 89748-89748.7 Hz
91245-91245.7 Hz 91271-91271.7 Hz 91877-91877.7 Hz 92182-92182.7 Hz
92361.3-92362 Hz 92787-92787.7 Hz 93332-93332.7 Hz 93530-93530.7 Hz
94494-94494.7 Hz 94968.3-94969 Hz 95245-95245.7 Hz 95742-95742.7 Hz
99281-99281.7 Hz 99846-99846.7 Hz
[0081] In certain embodiments, the cancer spécifie AM frequencies provided in Table A may also be used in combination with one or more of the AM frequencies disclosed in the ‘365 patent. One or more of the AM frequencies of Table A may be combined with one or more of the frequencies as provided below in Tables 2, 4, 7, 13, 16 18, 20 and 23-32. In preferred embodiments, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more frequencies are used in the methods for the treatment of cancer, which frequencies are selected from Table A and, optionally from Tables 2, 4, 7, 13, 16 18, 20 and 23-32, provided that at least one or more frequencies are selected from Table A.
|0082] The device and method described herein for the treatment of different cancer types by the application to the patient of electromagnetîc fîeids that are amplilude-modulated at particular and cancer-specific frequencies may be used as a stand-alone cancer therapy or use in conjunction with other now or hereafter known cancer treatment modalities. The device and method described 15 herein, may be used in combination with surgical intervention, radiotherapy and/or chemotherapy.
[0083] When used in combination with other cancer thérapies, the treatments methods described in this disclosure may be used as an adjuvant or neoadjuvant therapy in the treatment of cancer. For neoadjuvant therapy, the treatment methods described in this disclosure are adminîstered to the subject before a main treatment. Such neoadjuvant therapy may be applied to reduce the extern and/or size of the cancer prior to the use of a more radical treatment intervention, or to lower the risk of re-occurrence and/or metastasis followîng the main treatment. The use of the disclosed methods as a neoadjuvant therapy may resuit in the main treatment being easier and more likely to succeed, thereby reducing the sîde-effects and/or improving the outcome of the more extensive treatment. The main treatment may be a surgical intervention, radiotherapy and/or chemotherapy. [0084] The treatments methods described in this disclosure may be used as an adjuvant therapy, which is adminîstered in addition to the main therapy to improve its effectiveness. The main therapy may be surgery, radiotherapy and/or chemotherapy. The adjuvant therapy may be adminîstered concurrently with the main therapy and/or after the main therapy. The adjuvant therapy may be used to reduce or prevent récurrence of the cancer after a subject is treated by a main therapy, such as surgery, radiotherapy and/or chemotherapy.
[0085] Treatment of Breast Cancer
[0086] Breast cancer may be treated according to the methods disclosed herein by the application of breast cancer spécifie amplitude-modulated frequencies. Breast cancer spécifie frequencies are provided below in Table 1. A patient suffering from breast cancer may be treated with any number of the frequencies provided in Table 1, however it is generally préférable to employ as many of the frequencies as îs practical for the treatment of the patient. Accordîngly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of the listed breast cancer spécifie frequencies may be used in the treatment of breast cancer. It should be noted that while the table below provides certain frequencies for treatment of breast cancer, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of breast cancer are within the scope of this disclosure. Furthermore, each of the frequencies listed below include values that are close to (i.e., within +/- 0.1 Hz), but not exactly, the number or range.
[0087] Table 1: Amplitude-modulated frequencies discovered to be effective for treatment of breast cancer.
374-374.7 Hz 419.8-420.4 Hz 420.4-420.8 Hz 429-429.7 Hz 1336-1336.7 Hz
1369-1369.7 Hz 1728-1728.7 Hz 1771.8-1772.3 Hz 1772.3-1772.8 Hz 2811-2811.7 Hz
2824-2824.7 Hz 2840-2840.7 Hz 2858.8-2859.35Hz 2860-2860.7 Hz 2878-2878.7 Hz
2890-2890.7 Hz 3209-3209.7 Hz 3322-3322.7 Hz 3360-3360.7 Hz 3663-3663.7 Hz
3839-3839.7 Hz 3842.4-3843 Hz 3854-3854.7 Hz 3936-3936.7 Hz 4323-4323.7 Hz
4329-4329.7 Hz 4416-4416.7 Hz 4430-4430.7 Hz 4477.4-4478 Hz 4480.9-4481.35 Hz
4714-4714.7 Hz 4805.3-4806 Hz 4813-4813.7 Hz 4819-4819.7 Hz 4822-4822.7 Hz
4823-4823.7 Hz 4833-4833.7 Hz 4890-4890.7 Hz 5154-5154.7 Hz 5243-5243.7 Hz
5407.3-5408 Hz 5716-5716.7 Hz 5976-5976.7 Hz 6024-6024.7 Hz 6070-6070.7 Hz
6094-6094.7 Hz 6414-6414.7 Hz 6717-6717.7 Hz 6751-6751.7 Hz 6968.4-6969 Hz
7013-7013.7 Hz 7042-7042.7 Hz 7080-7080.7 Hz 7145.4-7146 Hz 7151-7151.7 Hz
7158-7158.7 Hz 7225-7225.7 Hz 8332-8332.7 Hz 8824-8824.7 Hz 8837-8837.7 Hz
9935-9935.7 Hz 9961-9961.7 Hz 10013-10013.7 Hz 10064-10064.7 Hz 10339.8-10340.4 Hz
10384-10384.7 Hz 10745-10745.7 Hz 10788-10788.7 Hz 10834-10834.7 Hz 10854-10854.7 Hz
10873-10873,7 Hz 10894-10894.7 Hz 11163-11163.7 Hz 11414-11414.7 Hz 11421-11421.7 Hz
11429-11429.7 Hz 11719-11719.7 Hz 11745-11745.7 Hz 11931-11931,7 Hz 11974-11974.7 Hz
11993-11993.7 Hz 12118-12118.7 Hz 12137-12137.7 Hz 12144-12144.7 Hz 12318-12318.7 Hz
12342-12342.7 Hz 12364-12364.7 Hz 12557-12557.7 Hz 12588-12588.7 Hz 13329-13329.7 Hz
13377-13377.7 Hz 13386-13386.7 Hz 13644-13644.7 Hz 13661-13661.7 Hz 13713-13713.7 Hz
14164-14164.7 Hz 14308-14308.7 Hz 14333.4-14333.9 Hz 14432-14432.7 Hz 14524-14524.7 Hz
14589-14589.7 Hz 14729-14729.7 Hz 14813-14813.7 Hz 14835-14835.7 Hz 14858-14858.7 Hz
14885-14885.7 Hz 15035-15035.6 Hz 15067-15067.7 Hz 15126-15126.7 Hz 15195-15195.7 Hz
15269-15269.7 Hz 15432-15432.7 Hz 15432-15432.7 Hz 15563-15563.7 Hz 15621-15621.7 Hz
15624-15624.7 Hz 15642-15642.7 Hz 15647-15647.7 Hz 15669-15669.7 Hz 15698-15698.7 Hz
15823-15823.7 Hz 16347-16347.7 Hz 17832-17832.7 Hz 18221-18221.7 Hz 18260-18260.7 Hz
19433-19433.7 Hz 19446-19446.7 Hz 19489.3-19490 Hz 19782-19782.7 Hz 19827-19827.7 Hz
21291.4-21292 Hz 21887-21887.7 Hz 22020-22020.7 Hz 22419-22419.7 Hz 22422-22422.7 Hz
22425-22425.7 Hz 22444-22444.7 Hz 22491-22491.7 Hz 22840.3-22841 Hz 22859-22859.7 Hz
22973-22973.7 Hz 22983-22983.7 Hz 23258-23258.7 Hz 23652-23652.7 Hz 24174-24174.7 Hz
24811-24811.7 Hz 26954-26954.7 Hz 27114-27114.7 Hz 30463.3-30464 Hz 34557.3-34558 Hz
34854-34854.7 Hz 38144-38144.7 Hz 38682-38682.7 Hz 41561-41561.7 Hz 41623-41623.7 Hz
41735-41735.7 Hz 42713-42713.7 Hz 44575.3-44576 Hz 46662-46662.7 Hz 48173-48173.7 Hz
50292-50292.7 Hz ________-____________
[0088] In certain embodiments, the frequencies listed above may also be used in combination 5 with one or more of the frequencies disclosed in the ‘365 patent. Specifically, treatment modalifies for treatment of breast cancer in accordance with this disclosure may include application of one, some or ail of the above listed frequencies with one or more of the frequencies disclosed in Table
for breast cancer. Alternatively and/or additionally, the frequencies disclosed in the ‘365 patent may be used for treatment of breast cancer using the methods and Systems described herein.
[0089] Table 2: Amplitude-modulated frequencies for treatment of breast cancer.
78.76 Hz 181.821 Hz 331.3 Hz 414.817 Hz 430.439 Hz
440.933 Hz 618.8 Hz 628.431 Hz 655.435 Hz 677.972 Hz
721.313 Hz 752.933 Hz 813.205 Hz 818.342 Hz 825.145 Hz
839.521 Hz 841.211 Hz 843.312 Hz 891.901 Hz 929.095 Hz
929.1 Hz 929.131 Hz 958.929 Hz 1021 Hz 1021.311 Hz
1156.79 Hz 1372.207 Hz 1372.934 Hz 1555.282 Hz 1588.721 Hz
1624.802 Hz 1670.699 Hz 1821.729 Hz 1836.219 Hz 2193.937 Hz
2221.323 Hz 2278.312 Hz 2332.949 Hz 2357.832 Hz 2381.443 Hz
2417.323 Hz 2423.292 Hz 2431.334 Hz 2450.332 Hz 2551.313 Hz
2556.221 Hz 2598.853 Hz 2621.322 Hz 2740.191 Hz 2823.428 Hz
2831.386 Hz 2851.347 Hz 2885.322 Hz 2919.273 Hz 3074.333 Hz
3115.188 Hz 3239.212 Hz 3249.529 Hz 3405.182 Hz 3432.274 Hz
3434.693 Hz 3594.231 Hz 3647.619 Hz 3657.931 Hz 3742.957 Hz
3753.382 Hz 3830.732 Hz 3855.823 Hz 3916.321 Hz 3935.218 Hz
3975.383 Hz 3993.437 Hz 4153.192 Hz 4194.968 Hz 4241.321 Hz
4243.393 Hz 4253.432 Hz 4314.444 Hz 4318.222 Hz 4375.962 Hz
4393.419 Hz 4394.134 Hz 4417.243 Hz 4481.463 Hz 4482.223 Hz
4495.138 Hz 4549.808 Hz 4558.306 Hz 4751.908 Hz 4779.451 Hz
4838.674 Hz 4871.513 Hz 4878.687 Hz 4895.296 Hz 4962.213 Hz
4969.224 Hz 4979.321 Hz 5027.231 Hz 5059.792 Hz 5118.094 Hz
5176.287 Hz 5365.222 Hz 5376.392 Hz 5426.323 Hz 5431.542 Hz
5521.621 Hz 5536.242 Hz 5739.422 Hz 5745.218 Hz 5821.975 Hz
6037.432 Hz 6044.333 Hz 6086.256 Hz 6208.932 Hz 6212.808 Hz
6231.031 Hz 6280.321 Hz 6329.391 Hz 6476.896 Hz 6477.098 Hz
6497.319 Hz 6504.983 Hz 6651.276 Hz 6657.913 Hz 6757.901 Hz
6758.321 Hz 6855.286 Hz 6858.121 Hz 6898.489 Hz 6915.886 Hz
7092.219 Hz 7120.218 Hz 7127.311 Hz 7156.489 Hz 7208.821 Hz
7224.197 Hz 7282.169 Hz 7285.693 Hz 7376.329 Hz 7488.742 Hz
7541.319 Hz 7577.421 Hz 7621.085 Hz 7627.207 Hz 7650.939 Hz
7668.231 Hz 7691.212 Hz 7842.184 Hz 7849.231 Hz 7915.423 Hz
7932.482 Hz 7949.196 Hz 7967.311Hz 8021,229 Hz 8070.181 Hz
8114.032 Hz 8149.922 Hz 8194.19 Hz 8245.801 Hz 8328.322 Hz
8330.534 Hz 8355.987 Hz 8408.121 Hz 8431.184 Hz 8452.119 Hz
8548.324 Hz 8749.383 Hz 8782.421 Hz 8784.424 Hz 8887.182 Hz
8894.222 Hz 8923.1 Hz 8923.361 Hz 8935.752 Hz 8936.1 Hz
9012.282 Hz 9012.896 Hz 9060.323 Hz 9072.409 Hz 9131.419 Hz
9199.232 Hz 9245.927 Hz 9270.322 Hz 9279.193 Hz 9393.946 Hz
10227.242 Hz 10340.509 Hz 10363.313 Hz 0449.323 Hz 10456.383 Hz
10468.231 Hz 10470.456 Hz 10472.291 Hz 10689.339 Hz 10832.222 Hz
11525.121 Hz 11541.915 Hz 11812.328 Hz 11812.419 Hz 11840.323 Hz
11925.089 Hz 12123.281 Hz 12267.281 Hz 12294.283 Hz 12334.419 Hz
12611.288 Hz 12629.222 Hz 12633.372 Hz 12648.221 Hz 13315.335 Hz
13331.358 Hz 13735.241 Hz 13826.325 Hz 13853.232 Hz 13915.231 Hz
13990.123 Hz 14122.942 Hz 14162.332 Hz 14519.232 Hz 14543.128 Hz
15651.323 Hz 17352.085 Hz 17970.122 Hz 18524.419 Hz 18619.331 Hz
18662.112 Hz 18679.492 Hz 18785.463 Hz 19385.893 Hz 19406.211 Hz
22479.333 Hz 30182.932 Hz
[0090] One or more of the AM frequencies of Table 1 may be used in combination with one or more of the frequencies provided in Table 2. In preferred embodiments, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 5 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more frequencies are used in the methods for the treatment of breast cancer, which frequencies are selected from Table 1 and, optionally from Table 2, provided that at least one or more frequencies are selected from Table 1.
[0091] Treatment of neuroendocrine tumors
[0092] Neuroendocrine tumors may be treated according to the methods disclosed herein by the 10 application of neuroendocrine tumor spécifie amplitude-modulated frequencies. Neuroendocrine tumors spécifie frequencies are provided below in Table 3. A patient suffering from neuroendocrine tumors may be treated with any number of the frequencies provided in Table 3, however it is generally préférable to employ as many of the frequencies as is practical for the trealment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or 15 more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, or more, or 100 or more of the listed neuroendocrine tumor spécifie frequencies may be used in the treatment of neuroendocrine tumors. It should be noted that while the table below provides certain frequencies for treatment of neuroendocrine tumors, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of neuroendocrine tumors are within the scope of this disclosure. Furthermore, each of the frequencies listed below include values that are close to (i.e., within +/- 0.1 Hz), but not exactly, the number or range.
[0093] Table 3: Amplitude-modulated frequencies discovered to be effective for treatment of neuroendocrine tumors.
843-843.7 Hz 1656-1656.7 Hz 2423-2423.7 Hz 2480-2480.7 Hz 2707-2707.7 Hz
2890-2890.7 Hz 3080.3-3081 Hz 3661-3661.7 Hz 3678-3678.7 Hz 3976.4-3977 Hz
4048-4048.7 Hz 4055-4055.7 Hz 4368.3-4369 Hz 4459-4459.7 Hz 4621-4621.7 Hz
4837-4837.7 Hz 4866-4866.7 Hz 5165.4-5166 Hz 5265-5265.7 Hz 5270-5270.7 Hz
6436-6436.7 Hz 7037-7037.7 Hz 8008-8008.7 Hz 8024-8024.7 Hz 8097-8097.7 Hz
8427-8427.7 Hz 8478.3-8479 Hz 8480-8480.7 Hz 8492-8492.7 Hz 8853-8853.7 Hz
8877-S877.7 Hz 9122-9122.7 Hz 9131-9131.7 Hz 9174-9174.7 Hz 10073-10073.7 Hz
10848.7-10849.3 Hz 11267-11267.7 Hz 11336-11336.7 Hz 11524-11524.7 Hz 11551.3-11552 Hz
11927.4-11928 Hz 12309-12309.7 Hz 13617-13617.7 Hz 13674-13674.7 Hz 13774-13774.7 Hz
14350-14350.7 Hz 14456-14456.7 Hz 14479-14479.7 Hz 14540-14540.7 Hz 14553-14553.7 Hz
14756-14756.7 Hz 14922-14922.7 Hz 14961-14961.7 Hz 15226-15226.7 Hz 15817-15817.7 Hz
15825-15825.7 Hz 15835-15835.7 Hz 15836-15836.7 Hz 15897-15897.7 Hz 16071-16071.7 Hz
17417-17417.7 Hz 17418-17418.7 Hz 17473-17473.7 Hz 17474-17474.7 Hz 17621-17621.7 Hz
17655-17655.7 Hz 18655-18655.7 Hz 18672-18672.7 Hz 18678-18678.7 Hz 19393-19393.7 Hz
19426-19426.7 Hz 19817-19817.7 Hz 19819-19819.7 Hz 19861-19861.7 Hz 19867-19867.7 Hz
20818-20818.7 Hz 21708-21708.7 Hz 21720-21720.7 Hz 21865-21865.7 Hz 21876-21876.7 Hz
22119-22119.7 Hz 22454-22454.7 Hz 24073-24073.7 Hz 30304-30304.7 Hz 31685-31685.7 Hz
43633-43633.7 Hz 44773-44773.7 Hz 46662-46662.7 Hz 46793-46793.7 Hz 48103-48103.7 Hz
50243-50243.7 Hz
[0094] In certain embodiments, the frequencies listed above may also be used in combination with one or more of the frequencies dîsclosed in the ‘365 patent. Specifically, treatment modalities for treatment of neuroendocrine tumors in accordance with this disclosure may include application 5 of some or ail of the above listed frequencies with one or more of the frequencies dîsclosed în the
Table 4 for neuroendocrine cancer. Alternatively and/or additionally, the frequencies dîsclosed in the ‘365 patent may be used for treatment of neuroendocrine tumors using the methods and Systems described herein.
[0095] Table 4: Amplitude-modulated frequencies for treatment of neuroendocrine tumors.
1766.335 Hz 2408.225 Hz 2441.502 Hz 2647.938 Hz 2741.261 Hz
3020.212 Hz 3128.822 Hz 3238.742 Hz 3296.431 Hz 3348.783 Hz
3360.971 Hz 3440.212 Hz 3533.328 Hz 3666.283 Hz 4079.282 Hz
4243.393 Hz 4426.387 Hz 5245.818 Hz 5536.242 Hz 5548.879 Hz
5739.422 Hz 5849.241 Hz 6291.631 Hz 6406.891 Hz 6780.679 Hz
7151.264 Hz 7482.245 Hz 7575.393 Hz 8359.932 Hz 9073.418 Hz
[0096] One or more of the AM frequencies of Table 3 may be combined with one or more of the frequencies as provided in Table 4. In preferred embodiments, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more frequencies are used in the methods for the 15 treatment of breast cancer, which frequencies are selected from Table 3 and, optionally from Table
4, provided that at least one or more frequencies are selected from Table 3.
[0097] Treatment of non-Hodgkin iymphoma
[0098] Non-Hodgkin lymphoma may be treated according to the methods disclosed herein by the application of non-Hodgkin lymphoma spécifie amplitude-modulated frequencies. NonHodgkin lymphoma tumor spécifie frequencies are provided below in Table 5. A patient suffering from non-Hodgkin lymphoma may be treated with any number of the frequencies provided in Table 5, however it is generally préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more of the listed non-Hodgkin lymphoma spécifie frequencies may be used in the treatment of non-Hodgkin lymphoma tumors. It should be noted that while the table below provides certain frequencies for treatment of non-Hodgkin lymphoma tumors, the disclosure is not so lîmiting, and other frequencies discovered to be effective in the treatment of non-Hodgkin lymphoma tumors are within the scope of this disclosure. Furthermore, each of the frequencies lîsted below include values that are close to (î.e., within +/- 0.1 Hz), but not exactly, the number or range.
[0099] Table 5: Amplitude-modulated frequencies discovered to be effective for treatment of non-Hodgkin lymphoma.
3222-3222.7 Hz 3228-3228.7 Hz 3272-3272.7 Hz 3618-3618.7 Hz 4523-4523.7 Hz
4556-4556.7 Hz 4584-4584.7 Hz 5116-5116.7 Hz 5142-5142.7 Hz 6413-6413.7 Hz
6419.3-6420 Hz 6441-6441.7 Hz 6474-6474.7 Hz 6911.3-6912 Hz 6912-6912.7 Hz
6943-6943.7 Hz 7551-7551.7 Hz 7811-7811.7 Hz 7857-7857.7 Hz 7865-7865.7 Hz
8125-8125.7 Hz 9106-9106.7 Hz 9161-9161.7 Hz 9179-9179.7 Hz 9230-9230.7 Hz
9236-9236.7 Hz 9247-9247.7 Hz 11730.6-11731.1 Hz 11785-11785.7 Hz 13222-13222.7 Hz
13751-13751.7 Hz 13780-13780.7 Hz 15006-15006.7 Hz 15033-15033.7 Hz 15056-15056.7 Hz
15729-15729.7 Hz 15773-15773.7 Hz 17229-17229.7 Hz 17246-17246.7 Hz 17268-17268.7 Hz
20256-20256.7 Hz 22444-22444.7 Hz 30666-30666.7 Hz 30713-30713.7 Hz. 30843-30843.7 Hz
38216-38216.7 Hz
[00100] Treatment of adenocarcinoma of pancréas
[00101] Adenocarcinoma of pancréas may be treated according to the methods disclosed herein by the application of adenocarcinoma of pancréas spécifie amplitude-modulated frequencies. Adenocarcinoma of pancréas spécifie frequencies are provided below in Table 6. A patient suffering from adenocarcinoma of pancréas may be treated with any number of the frequencies provided în Table 6, however it is generally préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of the listed spécifie frequencies may be used in the treatment of adenocarcinoma of pancréas. It should be noted that while the table below provides certain frequencies for treatment of adenocarcinoma of pancréas, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of adenocarcinoma of pancréas 5 are within the scope of this disclosure. Furthermore, each of the frequencies listed below include values that are close to (i.e., within +/- 0.1 Hz), but not exactly, the number or range.
[00102] Table 6: Amplitude-modulated frequencies discovered to be effective for treatment of adenocarcinoma of the pancréas.
403-403.7 Hz 441-441.7 Hz 527-527.7 Hz 624.32-624.8 Hz 633-633.7 Hz
727-727.7 Hz 759-759.7 Hz 785-785.7 Hz 811-811.7 Hz 829-829.7 Hz
841-841.7 Hz 962-962.7 Hz 964.5-965 Hz 972-972.7 Hz 974.4-975 Hz
977-977.7 Hz 1179.2-1179.8 Hz 1250.3-1251 Hz 1314-1314.7 Hz 1352-1352.7 Hz
1622-1622.7 Hz 1652-1652.7 Hz 1656-1656.7 Hz 1670.3-1671 Hz 1914-1914.7 Hz
2346-2346.7 Hz 2362-2362.7 Hz 2380-2380.7 Hz 2469.2-2469.7 Hz 2627-2627.7 Hz
2706-2706.7 Hz 2720.3-2721 Hz 2726-2726.7 Hz 2754-2754.7 Hz 2778-2778.7 Hz
2842-2842.7 Hz 2864-2864.7 Hz 2940-2940.7 Hz 2988-2988.7 Hz 3234-3234.7 Hz
3280.6-3281.3 Hz 3366-3366.7 Hz 3428-3428.7 Hz. 3446-3446.7 Hz 3466-3466.7 Hz
3523-3523.7 Hz 3605-3605.7 Hz 3622.5-3623 Hz 3627-3627.7 Hz 3631-3631.7 Hz
3656-3656.7 Hz 3663-3663.7 Hz 3667-3667.7 Hz 3687-3687.7 Hz 4152-4152.7 Hz
4233-4233.7 Hz 4249-4249.7 Hz 4281-4281.7 Hz 4368.3-4369 Hz 4417-4417.7 Hz
4425-4425.7 Hz 4440.4-4441 Hz 4465-4465.7 Hz 4480.9-4481.35 Hz 4580.11-4580.7 Hz
4621-4621.7 Hz 4637-4637.7 Hz 4657-4657.6 Hz 4725-4725.7 Hz 4733-4733.7 Hz
4749-4749.7 Hz 4841-4841.7 Hz 4924-4924.7 Hz 4946-4946.7 Hz 5063-5063.7 Hz
5089-5089.7 Hz 5378.2-5378.7 Hz 5424-5424.7 Hz 5438-5438.7 Hz 6112-6112.7 Hz
6159-6159.7 Hz 6161.3-6162 Hz 6167-6167.7 Hz 6179-6179.7 Hz 6220.3-6221 Hz
6346-6346.7 Hz 6380.4-6381 Hz 6808-6808.7 Hz 6825-6825.7 Hz 6847-6847.7 Hz
6850-6850.7 Hz 6878-6878.7 Hz 7036-7036.7 Hz 7037-7037.7 Hz 7118-7118.7 Hz
7160-7160.7 Hz 7432-7432.7 Hz 7541-7541.7 Hz 7676-7676.7 Hz 7936-7936.7 Hz
8024-8024.7 Hz 8032-8032.7 Hz 8043-8043.7 Hz 8447-8447.7 Hz 8734-8734.7 Hz
8756-8756.7 Hz 8757-8757.7 Hz 8809-8809.7 Hz 8823-8823.7 Hz 8841-8841.7 Hz
8845-8845.7 Hz 8846-8846.7 Hz 8872-8872.7 Hz 9133-9133.7 Hz 9155.7-9156.2 Hz
9520-9520.7 Hz 9859-9859.7 Hz 10342-10342.6 Hz 10352-10352.7 Hz 10378-10378.7 Hz
10436-10436.7 Hz 10566.4-10567 Hz 10633-10633.7 Hz 10641-10641.7 Hz 10671-10671.7 Hz
10708-10708.7 Hz 10859-10859.7 Hz 10876-10876.7 Hz 11174-11174.7 Hz 11220-11220.7 Hz
11247-11247.7 Hz 11264-11264.7 Hz 11284-11284.7 Hz 11630-11630.7 Hz 11994-11994.7 Hz
12120.2-12120.7 Hz 12135-12135.7 Hz 12152-12152.7 Hz 12184-12184.7 Hz 12711-12711,7 Hz
13375-13375.7 Hz 13571-13571.7 Hz 13636.2-13636.7 Hz 13738.3-13739 Hz 13947-13947.7 Hz
14116-14116.7 Hz 14279-14279.7 Hz 14376-14376.7 Hz 14462-14462.7 Hz 14519-14519.7 Hz
14558-14558.7 Hz 14729-14729.7 Hz 14940.4-14941 Hz 14957-14957.7 Hz 15179-15179.7 Hz
15225-15225.6 Hz 15536-15536.7 Hz 15576-15576.7 Hz 15597-15597.7 Hz 15663-15663.7 Hz
15678-15678.7 Hz 15711-15711.7 Hz 15724-15724.7 Hz 15740-15740.7 Hz 15749-15749.7 Hz
15824-15824.7 Hz 15867-15867.7 Hz 16143-16143.7 Hz 17214-17214.7 Hz 17253-17253.7 Hz
17271-17271.7 Hz 17283-17283.7 Hz 17739-17739.7 Hz 17944-17944.7 Hz 17962-17962.7 Hz
18279-18279.7 Hz 18678.7-18679.3 Hz 18921-18921.7 Hz 18922-18922.7 Hz 19059-19059.7 Hz
19464-19464.7 Hz 19686-19686.4 Hz 19724-19724.7 Hz 20123-20123.7 Hz 20128-20128.7 Hz
20144-20144.7 Hz 20149.3-20150 Hz 20219-20219.7 Hz 20254-20254.7 Hz 21546-21546.7 Hz
21616-21616.7 Hz 21664-21664.7 Hz 21840-21840.7 Hz 21876-21876.7 Hz 21894-21894.7 Hz
22355-22355.7 Hz 22430-22430.7 Hz 22597-22597.7 Hz 22742-22742.7 Hz 22822-22822.7 Hz
22846-22846.7 Hz 22867-22867.7 Hz 23237-23237.7 Hz 23284-23284.7 Hz 24228-24228.7 Hz
24275-24275.7 Hz 24508-24508.7 Hz 24609.3-24610 Hz 24841-24841.7 Hz 27478-27478.7 Hz
32143-32143.7 Hz 32493-32493.7 Hz 33546-33546.7 Hz 40133-40133.7 Hz 40595-40595.7 Hz
44913-44913.7 Hz 45474-45474.7 Hz 46672.3-46673 Hz 48204-48204.7 Hz 48314-48314.7 Hz
50072-50072.7 Hz 50254-50254.7 Hz 52812-52812.7 Hz 79867-79867.7 Hz 80993.3-80994 Hz
91877-91877.7 Hz 95742-95742.7 Hz.
[00103] In certain embodiments, the frequencies listed above may also be used in combination with one or more of the frequencies disclosed in the 365 patent. Specifically, treatment modalities for treatment of adenocarcinoma of the pancréas in accordance with this disclosure may include 5 application of some or ail of the above listed frequencies with one or more of the frequencies disclosed in the Table 7. Alternatively and/or additionally, the frequencies disclosed in the ‘365 patent may be used for treatment of adenocarcinoma of pancréas State using the methods and Systems described herein.
[00104] Table 7: Amplitude-modulated frequencies for treatment of pancreatic cancer.
331.3 Hz 331.365 Hz 436.3 Hz 436.332 Hz 447.942 Hz
476.127 Hz 559.292 Hz 589.187 Hz 624.218 Hz 727 Hz
734.921 Hz 809.313 Hz 845.309 Hz 870.4 Hz 963.221 Hz
1156.79 Hz 1157 Hz 1179 Hz 1360.133 Hz 1372.207 Hz
1372.934 Hz 1804.126 Hz 1816.221 Hz 1873.477 Hz 1967.211 Hz
1990.482 Hz 2278.312 Hz 2315.921 Hz 2320.315 Hz 2334.178 Hz
2381.443 Hz 2469 Hz 2477.919 Hz 2542.221 Hz 2598.853 Hz
2647.938 Hz 2685.081 Hz 2716.095 Hz 2721.331 Hz 2732.231 Hz
2809.849 Hz 2823.428 Hz 2835.332 Hz 3134.313 Hz 3241.461 Hz
3255.219 Hz 3263.432 Hz 3286.255 Hz 3330.935 Hz 3373.892 Hz
3438.109 Hz 3449.219 Hz 3535.219 Hz 3549.215 Hz 3564.419 Hz
3619.412 Hz 3622.312 Hz 3638.432 Hz 3696.424 Hz 3943.214 Hz
3976.929 Hz 4014.889 Hz 4041.219 Hz 4044.195 Hz 4056.384 Hz
4085.971 Hz 4144.592 Hz 4153.192 Hz 4161.889 Hz 4243.393 Hz
4332.498 Hz 4341.423 Hz 4355.327 Hz 4417.885 Hz 4422.322 Hz
4451.297 Hz 4486.384 Hz 4558.306 Hz 4580 Hz 4685.082 Hz
4839.589 Hz 5151.402 Hz 5209.911 Hz 5262.282 Hz 5271.312 Hz
5387.73 Hz 5494.928 Hz 5521.221 Hz 5573.209 Hz 5609.382 Hz
5929.616 Hz 5948.897 Hz 5966.112 Hz 5976.825 Hz 6064.197 Hz
6086.256 Hz 6157.253 Hz 6215.298 Hz 6333.917 Hz 6365.242 Hz
6558.342 Hz 6568.278 Hz 6823.194 Hz 6853.391 Hz 6855.286 Hz
7213.204 Hz 7228.528 Hz 7238.232 Hz 7277.921 Hz 7280.422 Hz
7320.494 Hz 7366.412 Hz 7534.221 Hz 7548.713 Hz 7567.127 Hz
7620.851 Hz 7663.209 Hz 7725.203 Hz 7852.233 Hz 7920.879 Hz
7985.122 Hz 8008.323 Hz 8013.312 Hz 8045.484 Hz 8242.332 Hz
8351.622 Hz 8408.121 Hz 8455.894 Hz 8551.231 Hz 8743.321 Hz
8789.631 Hz 8868.809 Hz 9012.241 Hz 9028.994 Hz 9131.232 Hz
9658.296 Hz 9663.495 Hz 9680.737 Hz 9824.442 Hz 9942.321 Hz
10279.122 Hz 10388.49 Hz 10438.495 Hz 10518.311 Hz 10528.239 Hz ___
10582.095 Hz 10926.111 Hz 10948.411 Hz 1.0955.558 Hz 11538.193 Hz___
11904.741 Hz 12255.229 Hz 12613.341 Hz 12819.942 Hz 13674.482 Hz
13731.322 Hz 14525.312 Hz 14537.218 Hz 14549.331 Hz 14845.453 Hz
14944.989 Hz 15246.315 Hz 18668.239 Hz 19321.231 Hz 19347.208 Hz
30182.932 Hz
[00105] One or more of the AM frequencies of Table 6 may be used in combination with one or more of the frequencies provided in Table 7. In preferred embodiments, 10 or more, 15 or more, 5 or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more frequencies are used in the methods for the treatment of adenocarcînoma of the pancréas, which frequencies are selected from Table 6 and, optionally from Table 7, provided that at least one or more frequencies are selected from Table 6.
[00106] Treatment of head and neck cancer
[00107] Head and neck cancer may be treated according to the methods disclosed herein by the application of head and neck cancer spécifie amplitude-modula ted frequencies. Head and neck cancer spécifie frequencies are provided below in Table 8. A patient suffering from head and neck 5 cancer may be treated with any number of the frequencies provided in Table 8, however it is generally préférable to empioy as many of the frequencies as is praclical for the treatment of the patient. Accordingly, 10 or more, 15 or more of the listed head and neck cancer spécifie frequencies may be used in the treatment of head and neck cancer. It should be noted that while the table below provides certain frequencies for treatment of head and neck cancer, the disclosure 10 is not so limiting, and other frequencies discovered to be effective in the treatment of head and neck cancer are within the scope of this disclosure. Furthermore, each of the frequencies listed below include values that are close to (i.e., within +/- 0.1 Hz), but not exactly, the number or range.
[00108] Table 8: Ampli tude-modulated frequencies discovered to be effective for treatment of
15 lead and neck cancer.
1858-1858.7 Hz 2893-2893.7 Hz 5152-5152.7 Hz 6897-6897.7 Hz 7080-7080.7 Hz
7136-7136.7 Hz 7274-7274.7 Hz 8755-8755.7 Hz 9573-9573.7 Hz 9656-9656.7 Hz _
10439-10439.7 Hz 10484-10484.7 Hz 10645-10645.7 Hz 10673-10673.7 Hz 11559-11559.7 Hz
14052-14052.7 Hz 17379-17379.7 Hz 19269-19269.7 Hz
[00109] Treatment of gastric cancer
[00110] Gastric cancer may be treated according to the methods disclosed herein by the 20 application of gastric cancer spécifie amplitude-modulated frequencies. Gastric cancer spécifie frequencies are provided below in Table 9. A patient suffering from gastric cancer may be treated with any number of the frequencies provided in Table 9, however it is generally préférable to empioy as many of the frequencies as is practicai for the treatment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or 25 more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of the listed gastric cancer spécifie frequencies may be used in the treatment of gastric cancer. It should be noted that while the table below provides certain frequencies for treatment of gastric cancer, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of
gastric cancer are within the scope of this disclosure. Furthermore, each of the frequencies listed beiow include values that are close to (i.e., within +/- 0.1 Hz), but not exactly, the number or range.
[00111] Table 9: Amplitude-modulated frequencies discovered to be effective for treatment of gastric cancer.
374-374.7 Hz 560-560.7 Hz 628-628.7 Hz 642.4-643 Hz 708.3-709 Hz
749-749.7 Hz 806-806.6 Hz 825-825.7 Hz 843-843.7 Hz 914-914.7 Hz
959-959.7 Hz 969-969.7 Hz 1157-1157.7 Hz 1436-1436.7 Hz 1656-1656.7 Hz
2379.3-2380 Hz 2417-2417.7 Hz 2436-2436.7 Hz 2455-2455.7 Hz 2478-2478.7 Hz
2747-2747.7 Hz 2762-2762.7 Hz 2774-2774.7 Hz 2856.4-2857 Hz 2891-2891.7 Hz
2981-2981.7 Hz 3104.3-3105 Hz 3133-3133.7 Hz 3522-3522.7 Hz 3537-3537.7 Hz
3549-3549.7 Hz 3556-3556.7 Hz 3595-3595.7 Hz 3927-3927.7 Hz 4154-4154.7 Hz
4548-4548.7 Hz 4723-4723.7 Hz 5286-5286.7 Hz 5494.4-5495 Hz 5548.3-5549 Hz
5742-5742.7 Hz 6010-6010.7 Hz 6064-6064.7 Hz 6329-6329.7 Hz 6444-6444.7 Hz
6469-6469.7 Hz 6488-6488.7 Hz 7222.4-7223 Hz 7646-7646.7 Hz 7748-7748.7 Hz
7855-7855.7 Hz 7927-7927.7 Hz 7951-7951.7 Hz 7970-7970.7 Hz 7979-7979.7 Hz
8039-8039.7 Hz 8055.4-8056 Hz 8926-8926.7 Hz 9109-9109.7 Hz 9123-9123.7 Hz
9136-9136.7 Hz 9146-9146.7 Hz 9157-9157.7 Hz 9194-9194.7 Hz 10137-10137.7 Hz
10345-10345.7 Hz 10727-10727.7 Hz 10802-10802.7 Hz 11533-11533.7 Hz 12165-12165.7 Hz
13241-13241.7 Hz 13307-13307.7 Hz 13330.7-13331.2 Hz 13408-13408.7 Hz 13434-13434.7 Hz
13714-13714.7 Hz 13746-13746.7 Hz 14016.4-14017 Hz 14160-14160.7 Hz 14483-14483.7 Hz
14511-14511.7 Hz 14670.4-14671 Hz 16309-16309.7 Hz 17418-17418.7 Hz 17455-17455.7 Hz
17485-17485.7 Hz 17581-17581.7 Hz 19125-19125.7 Hz 21430-21430.7 Hz 21714-21714.7 Hz
23946-23946.7 Hz 39586-39586.7 Hz 40734-40734.7 Hz 41172-41172.7 Hz 42146-42146.7 Hz
46143-46143.7 Hz ___________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________.
[00112] Treatment of glioblastoma
[00113] Glioblastoma may be treated according to the methods disclosed herein by the application of glioblastoma spécifie amplitude-modulated frequencies. Glioblastoma spécifie frequencies are provided below in Table 10. A patient suffering from glioblastoma may be treated with any 10 number of the frequencies provided in Table 10, however it is generaliy préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of the listed glioblastoma spécifie frequencies may be used in the treatment of glioblastoma. It shouid be noted 15 that while the table below provides certain frequencies for treatment of glioblastoma, the disclosure is not so lîmiting, and other frequencies discovered to be effective in the treatment of
glioblastoma are within the scope of this disclosure. Furthermore, each of the frequencies listed below include values that are close to (Le., within +/- 0.1 Hz), but not exactly, the number or range. [00114] Table 10: Amplitude-modulated frequencies discovered to be effective for treatment of glioblastoma.
262-262.7 Hz 295-295.6 Hz 415-415.7 Hz 418-418.7 Hz 423-423.7 Hz
434-434.7 Hz 440.4-441 Hz 476-476.7 Hz 556-556.7 Hz 608-608.7 Hz
612-612.7 Hz 627-627.7 Hz 656-656.7 Hz 694-694.7 Hz 708.3-709 Hz
741-741.7 Hz 752.4-753 Hz 757-757.6 Hz 759-759.7 Hz 776-776.7 Hz
796.3-797 Hz 836-836.7 Hz 941-941.7 Hz 1027-1027.7 Hz 1045-1045.7 Hz
1195-1195.7 Hz 1868-1868.7 Hz 1897-1897.7 Hz 2044-2044.7 Hz 2439-2439.7 Hz
2612-2612.7 Hz 2632-2632.7 Hz 2653.3-2654 Hz 2686-2686.7 Hz 2690-2690.7 Hz
2697-2697.7 Hz 2738-2738.7 Hz 3157-3157.7 Hz 3218-3218.7 Hz 3227.3-3228 Hz
3249-3249.7 Hz 3277.3-3278 Hz 3281.6-3282.1 Hz 3436-3436.7 Hz 3633-3633.7 Hz__
3656-3656.7 Hz 3962-3962.7 Hz 4148-4148.7 Hz 4241-4241.7 Hz 4410-4410.7 Hz
4416-4416.7 Hz 4454-4454.7 Hz 4619-4619.7 Hz 4632-4632.7 Hz 4853-4853.7 Hz
5139-5139.7 Hz 5156-5156.7 Hz 5996-5996.7 Hz 6292-6292.7 Hz 6297-6297.7 Hz__
6459-6459.7 Hz 6474-6474.7 Hz 6492.3-6493 Hz 6626.3-6627 Hz 6727.4-6728 Hz
6809-6809.6 Hz 6841-6841.7 Hz 6915.3-6916 Hz Ί 6943-6943.7 Hz 7110-7110.7 Hz
7182.4-7183 Hz 7194.3-7195 Hz 7268-7268.7 Hz 7323-7323.7 Hz 7480-7480.7 Hz
7663-7663.7 Hz 7796-7796.7 Hz 7936-7936.7 Hz 8070-8070.7 Hz 8128.4-8129 Hz
8145-8145.7 Hz 8158-8158.7 Hz 8314-8314.7 Hz 8355-8355.7 Hz 8484-8484.7 Hz
9138.3-9139 Hz 9155.7-9156.2Hz 9921-9921.7 Hz 10427-10427.7 Hz 10468-10468.7 Hz
10478-10478.7 Hz 10719-10719.7 Hz 10802-10802.7 Hz 10809-10809.7 Hz 10851-10851.7 Hz
11556-11556.7 Hz 11913-11913.7 Hz 12828.3-12829 Hz 13686.4-13687 Hz 14249-14249.7 Hz
14515.4-14516 Hz 14586.3-14587 Hz 14796-14796.7 Hz 15067-15067.7 Hz 15112-15112.7 Hz
17095-17095.7 Hz 17167-17167.7 Hz 18090-18090.7 Hz 18670.3-18671 Hz 18895-18895.7 Hz
19026-19026.7 Hz 20237-20237.7 Hz 20254-20254.7 Hz 20286-20286.7 Hz 24196-24196.7 Hz
25199-25199.7 Hz 26073-26073.7 Hz 26163-26163.7 Hz 26164-26164.7 Hz 30759-30759.7 Hz
32591.3-32592 Hz 36343-36343.7 Hz 41883-41883.7 Hz 44517-44517.7 Hz 44531-44531.7 Hz
45490-45490.7 Hz 47297-47297.7 Hz 49434-49434.7 Hz 50229-50229.7 Hz 69481-69481.7 Hz
78477.4-78478 Hz 80993.3-80994 Hz 81999-81999.7 Hz 85810-85810.7 Hz 89748-89748.7 Hz
92182-92182.7 Hz 95245-95245.7 Hz _____ ___
[00115] Treatment of squamous cell carcinoma of the anal canal
[00116] Squamous cell carcinoma of the anal canal may be treated according to the methods disclosed herein by the application of squamous cell carcinoma of the anal canal spécifie 10 amplitude-modulated frequencies. Squamous cell carcinoma of the anal canal spécifie frequencies are provided below in Table 11. A patient suffering from squamous cell carcinoma of the anal canal may be treated with any number of the frequencies provided in Table 11, however it is generally préférable to employ as many of the frequencies as is practical for the treatment of the
patient, Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more of the listed squamous cell carcinoma of the anal canal spécifie frequencies may be used in the treatment of squamous cell carcinoma of the anal canal, It should be noted that whîle the table below provides 5 certain frequencies for treatment of squamous cell carcinoma of the anal canal, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of squamous cell carcinoma of the anal canal are within the scope of this disclosure. Furthermore, each of the frequencies listed below include values that are close to (i.e., within +/- 0.1 Hz), but not exactly, the number or range.
[00117] Table 11: Amplitude-modulated frequencies discovered to be effective for treatment of squamous cell carcinoma of the anal canal.
295-295.6 Hz 304-304.7 Hz 436-436.7 Hz 581-581.7 Hz 679-679.7 Hz
694.3-695 Hz 708.3-709 Hz 796.3-797 Hz 1759-1759.7 Hz 1858-1858.7 Hz
1873-1873.7 Hz 2442-2442.7 Hz 2522-2522.7 Hz 2648-2648.7 Hz 2893-2893.7 Hz
2975-2975.7 Hz 2981-2981.7 Hz 3238-3238.7 Hz 3249.3-3250 Hz 3250.3-3250.8 Hz
3461-3461.7 Hz 3531-3531.7 Hz 3535-3535.7 Hz 3681-3681.7 Hz 4279-4279.7 Hz
4440.4-4441 Hz 4718-4718.7 Hz 4876-4876.7 Hz 5034-5034.7 Hz 5068-5068.7 Hz
5151-5151.7 Hz 5249-5249.7 Hz 5286-5286.7 Hz 5869-5869.7 Hz 5881-5881.7 Hz
6298.4-6299 Hz 6851-6851.7 Hz 6879-6879.7 Hz 6882.4-6883 Hz 6897-6897.7 Hz
6980.3-6981 Hz 7136-7136.7 Hz 7274-7274.7 Hz 7673-7673.7 Hz 7930-7930.7 Hz
7981-7981.7 Hz 8328-8328.7 Hz 8432-8432.7 Hz 8755-8755.7 Hz 8949-8949.7 Hz _
9656-9656.7 Hz 10439-10439.7 Hz 10484-10484.7 Hz 11145-11145.7 Hz 11159-11159.7 Hz
11253-11253.7 Hz 11260-11260.7 Hz 11277.3-11278 Hz 11559-11559.7 Hz 11699-11699.7 Hz
11905-11905.7 Hz 12139-12139.7 Hz 13819-13819.7 Hz 13847-13847.7 Hz 13903-13903.7 Hz
17379-17379.7 Hz 18618-18618.7 Hz 18742-18742.7 Hz 21445-21445.7 Hz 21467-21467.7 Hz
22763-22763.7 Hz 33536-33536.7 Hz 37527-37527.7 Hz 37546-37546.7 Hz 53079-53079.7 Hz
58094-58094.7 Hz 59288-59288.7 Hz 59997-59997.7 Hz 88281-88281.7 Hz
[00118] Treatment of hepatocellular carcinoma
[00119] Hepatocellular carcinoma may be treated according to the methods disclosed herein by the application of hepatocellular carcinoma spécifie amplitude-modulated frequencies.
Hepatocellular carcinoma spécifie frequencies are provided below in Table 12. A patient suffering from hepatocellular carcinoma may be treated with any number of the frequencies provided in Table 12, however it is generally préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, 20 or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of the listed hepalocellular carcinoma spécifie frequencies may be used in the treatment of hepatocellular carcinoma. Il should be noted that while the table below provides certain frequencies for treatment of hepatocellular carcinoma, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of hepatocellular 5 carcinoma are within the scope of this disclosure. Furthermore, each of lhe frequencies listed below include values that are close to (Le., within +/- 0.1 Hz), but not exactly, the number or range.
[00120] Table 12: Amplitude-modulated frequencies discovered to be effective for treatment of hepatocellular carcinoma.
439-439.7 Hz 594-594.7 Hz 737-737.7 Hz 817-817.7 Hz 966-966.7 Hz
996-996.7 Hz 1785-1785.7 Hz 1823-1823.7 Hz 1881-1881.7 Hz 1963-1963.7 Hz
1973-1973.7 Hz 2189-2189.7 Hz 2321-2321.7 Hz 2372.3-2372.8 Hz 2459-2459.7 Hz
2647-2647.7 Hz 2825-2825.7 Hz 2836-2836.7 Hz 2860-2860.7 Hz 2971-2971.6 Hz
3171-3171.7 Hz 3188-3188.7 Hz 3749.3749.7 Hz 3762-3762.7 Hz 3823-3823.7 Hz
4007-4007.7 Hz 4013-4013.7 Hz 4454-4454.7 Hz 4997-4997.7 Hz 5151-5151.7 Hz
5239-5239.7 Hz 5322-5322.7 Hz 6317-6317.7 Hz 6330-6330.7 Hz 6334-6334.7 Hz
6432-6432.7 Hz 6840-6840.7 Hz 7098-7098.7 Hz 7169-7169.7 Hz 7239-7239.7 Hz
7338-7338.7 Hz 7378-7378.7 Hz 7481-7481.7 Hz 7510-7510.7 Hz 7719-7719.7 Hz
7748-7748.7 Hz 7787-7787.7 Hz 8388-8388.7 Hz 8412-8412.7 Hz 9588-9588.7 Hz
8522-8522.7 Hz 8845-8845.7 Hz 8935-8935.6 Hz 8949-8949.7 Hz 9273-9273.7 Hz
9695-9695.7 Hz 10387-10387.7 Hz 10641-10641.7 Hz 10731-10731.7 Hz 10740-10740.7 Hz
10762-10762.7 Hz 10768-10768.7 Hz 10776-10776.7 Hz 10805-10805.7 Hz 10831-10831.7 Hz
10889-10889.7 Hz 11209-11209.7 Hz 11243-11243.7 Hz 11247-11247.7 Hz 11275-11275.7 Hz
11295-11295.7 Hz 11569-11569.7 Hz 11590-11590.7 Hz 11946-11946.7 Hz 12498-12498.7 Hz
12572-12572.7 Hz 12649-12649.7 Hz 13215-13215.7 Hz 13252-13252.7 Hz 13735-13735.7 Hz
13856-13856.7 Hz 14114-14114.7 Hz 14170.7-14171.3 Hz 14532-14532.7 Hz 14574-14574.7 Hz
15521-15521.7 Hz 15528-15528.7 Hz 15546.3-15547 Hz 15589-15589.7 Hz 15982-15982.7 Hz
16381-16381.7 Hz 17556-17556.7 Hz 17749-17749.7 Hz 17978-17978.7 Hz 18030-18030.7 Hz
18246-18246.7 Hz 18567-18567.7 Hz 18686-18686.7 Hz 18842-18842.7 Hz 18897-18897.7 Hz
19510-19510.7 Hz 20324-20324.7 Hz 20825-20825.7 Hz 20908-20908.7 Hz 21616-21616.7 Hz
21778-21778.7 Hz 21876-21876.7 Hz 22353-22353.7 Hz 22459-22459.7 Hz 22535-22535.7 Hz
22709-22709.7 Hz 23509-23509.7 Hz 23526-23526.7 Hz 23560-23560.7 Hz 23589-23589.7 Hz
23957-23957.7 Hz 24014-24014.7 Hz 24117-24117.7 Hz 24869-24869.7 Hz 25449-25449.7 Hz
25454-25454.7 Hz 26722-26722.7 Hz 26861-26861.7 Hz 30942-30942.7 Hz 31713-31713.7 Hz
32866-32866.7 Hz 32870-32870.7 Hz 33765-33765.7 Hz 34405-34405.7 Hz 34562-34562.7 Hz
34984-34984.6 Hz 36410-36410.7 Hz 38483-38483.7 Hz 38659-38659.7 Hz 39035-39035.7 Hz
39223-39223.7 Hz 39510-39510.7 Hz 39729-39729.7 Hz 40693-40693.7 Hz 41244-41244.7 Hz
41574-41574.7 Hz 42913-42913.7 Hz 42923-42923.7 Hz 43243-43243.7 Hz 43413-43413.7 Hz
43542-43542.7 Hz 43603-43603.7 Hz 44742-44742.7 Hz 47693.4-47694 Hz 51592-51592.7 Hz
53947-53947.7 Hz 55072-55072.7 Hz 56093-56093.7 Hz 59089-59089.7 Hz 66969-66969.7 Hz
67683-67683.7 Hz 76537-76537.7 Hz 78229-78229.7 Hz 82845-82845.7 Hz 83612-83612.7 Hz
84086-84086.7 Hz 91245-91245.7 Hz 92361.3-92362 Hz 93332-93332.7 Hz 93530-93530.7 Hz
94968.3-94969 Hz 99281-99281.7 Hz 99846-99846.7 Hz
[00121] In certain embodiments, the frequencies lîsted above may also be used in combination with one or more of the frequencies disclosed in the ‘365 patent, Specifically, treatment modalities for treatment of hepatocellular carcinoma in accordance with this disclosure may include 5 application of some or ail of the above listed frequencies with one or more of the frequencies disclosed in Table 13 for hepatocellular carcinoma. Alternatively and/or additionally, the frequencies disclosed in the ‘365 patent may be used for treatment of hepatocellular carcinoma State using the methods and Systems described herein.
[00122] Table 13: Amplitude-modulated frequencies for treatment of hepatocellular carcinoma.
380.293 Hz 410.231 Hz 423.321 Hz 427.062 Hz 434.332 Hz
470.181 Hz 560.32 Hz. 642.932 Hz 655.435 Hz 657.394 Hz
668.209 Hz 677.972 Hz 728.232 Hz 806.021 Hz 811.924 Hz
842.311 Hz 843.22 Hz 845.208 Hz 891.901 Hz 914.219 Hz
920.321 Hz 964.394 Hz 1250.504 Hz 1755.402 Hz 1814.223 Hz
1851.202 Hz 1873.477 Hz 1924.702 Hz 1975.196 Hz 2017.962 Hz
2053.396 Hz 2083.419 Hz 2190.731 Hz 2221.323 Hz 2308.294 Hz
2315.208 Hz 2324.393 Hz 2338.221 Hz 2353.478 Hz 2362.309 Hz
2379.571 Hz 2419.309 Hz 2425.222 Hz 2430.219 Hz 2431.094 Hz
2471.328 Hz 2478.331 Hz 2480.191 Hz 2522.328 Hz 2743.995 Hz
2744.211Hz 2831.951 Hz 2843.283 Hz 2859.891 Hz 2873.542 Hz
2886.232 Hz 3009.332 Hz 3020.286 Hz 3042.012 Hz 3044.213 Hz
3051.218 Hz 3076.892 Hz 3078.983 Hz 3086.443 Hz 3104.854 Hz
3127.232 Hz 3160.942 Hz 3161.331 Hz 3167.22 Hz 3206.315 Hz
3255.219 Hz 3267.433 Hz 3269.321 Hz 3281.432 Hz 3457.291 Hz
3505.229 Hz 3516.296 Hz 3530.188 Hz 3531.296 Hz 3546.323 Hz
3572.106 Hz 3576.189 Hz 3669.513 Hz 3923.221 Hz 3927.331 Hz
4013.932 Hz 4071.121 Hz 4079.951 Hz 4123.953 Hz 4161.889 Hz
4222.821 Hz 4238.402 Hz 4256.321 Hz 4289.296 Hz 4312.947 Hz
4375.962 Hz 4426.387 Hz 4428.185 Hz 4435.219 Hz 4471.188 Hz
4483.889 Hz 4486.384 Hz 4556.322 Hz 4629.941 Hz 4715.222 Hz
4732.211 Hz 4767.185 Hz 4873.333 Hz 4876.218 Hz 5086.281 Hz
5124.084 Hz 5133.121 Hz 5247.142 Hz 5270.834 Hz 5340.497 Hz
5520.218 Hz 5570.234 Hz 5882.292 Hz 5926.512 Hz 6037.311 Hz
6180.334 Hz 6329.195 Hz 6350.333 Hz 6361.321 Hz 6364.928 Hz
63S3.321 Hz 6461.175 Hz 6661.109 Hz 6711.392 Hz 6733.331 Hz
6758.232 Hz 6779.482 Hz 6856.222 Hz 6877.183 Hz 6915.886 Hz
6980.525 Hz 7019.235 Hz 7041.321 Hz 7043.209 Hz 7078.307 Hz
7130.323 Hz 7144.142 Hz 7210.223 Hz 7232.343 Hz 7291.21 Hz
7482.245 Hz 7510.92 Hz 7529.233 Hz 7549.212 Hz 7650.028 Hz
7680.518 Hz 7692.522 Hz 7829.231 Hz 7862.209 Hz 7932.482 Hz
7935.423 Hz 7947.392 Hz 7979.308 Hz 8025.322 Hz 8028.339 Hz
8055.942 Hz 8072.134 Hz 8141.174 Hz 8208.285 Hz 8328.312 Hz
8336.383 Hz 8394.793 Hz 8432.181 Hz 8452.119 Hz 8460.944 Hz
8475.221 Hz 8492.193 Hz 8542,311 Hz 8779.229 Hz 8818.104 Hz
8852.329 Hz 8853.444 Hz 8858.179 Hz 8915.221 Hz 8939.212 Hz
8953.231 Hz 8993.239 Hz 9278.889 Hz 9332.397 Hz 9381.221 Hz
9520.333 Hz 9719.314 Hz 9740.219 Hz 9768.331 Hz 9773.111 Hz
9797,294 Hz 9819.511 Hz 9845.319 Hz 10015.419 Hz 10043.293 Hz
10317.499 Hz 10438,495 Hz 10443.311 Hz 10456.383 Hz 10579.425 Hz
10863.209 Hz 10866.382 Hz 11067.418 Hz 11149.935 Hz 11163.895 Hz
11195.509 Hz 11421.219 Hz 11802.821 Hz 11953.424 Hz 12024.502 Hz
12223.329 Hz 12228.369 Hz 12247.233 Hz 12260,933 Hz 12265.295 Hz
12267.233 Hz 12267.296 Hz 12274.219 Hz 12623.191 Hz 12633.372 Hz
12685.231 Hz 12721,423 Hz 12785.342 Hz 13433.323 Hz 13457.388 Hz
14085.222 Hz 14212.122 Hz 14226.313 Hz 14333.209 Hz 14537.331 Hz
14542.432 Hz 14655.03 Hz 14736.223 Hz 14828.234 Hz 15149.213 Hz
15237.489 Hz 15560.908 Hz 15717.221 Hz 16110.932 Hz 16144.343 Hz
17153.322 Hz 17660.109 Hz 18121.184 Hz 18265.238 Hz 18283.323 Hz
18863.292 Hz 18930.995 Hz 19970.311 Hz 20330.294 Hz 20365.284 Hz
22321.331 Hz 24119.295 Hz 24181.221 Hz
[00123] One or more of the AM frequencies of Table 12 may be used in combination with one or more of the frequencies provided in Table 13. In preferred embodiments, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 5 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more frequencies are used in the methods for the treatment of hepatocellular carcinoma, which frequencies are selected from Table 12 and, optionally from Table 13, provided that at least one or more frequencies are selected from Table 12.
[00124] Treatment of cholangiocarcinoma
[00125] Cholangiocarcinoma may be treated according to the methods disclosed herein by the application of cholangiocarcinoma spécifie amplitude-modulated frequencies. Cholangiocarcinoma spécifie frequencies are provided below in Table 14. A patient suffering from cholangiocarcinoma may be treated with any number of the frequencies provided in Table 15 14, however it is generally préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of the listed cholangiocarcinoma spécifie frequencies may be used in the treatment of cholangiocarcinoma. It should be noted that while the table below provides certain
frequencies for treatment of cholangiocarcinoma, the disclosure is not so iimiting, and other frequencies discovered to be effective in the treatment of cholangiocarcinoma are within the scope of this disclosure. Furthermore, each of the frequencies listed below include values that are close to (Le., within +/- 0,1 Hz), but not exactly, the number or range.
[00126] Table 14: Amplitude-modulated frequencies discovered to be effective for treatment of cholangiocarcinoma.
334-334.7 Hz 380-380.7 Hz 410-410.7 Hz 427-427.6 Hz 434-434.7 Hz
476-476.7 Hz 527-527.7 Hz 560-560.7 Hz 624-624.7 Hz 642.4-643 Hz
657-657.7 Hz 677.4-678 Hz 728-728.7 Hz 806-806.6 Hz 809-809.7 Hz
845-845.7 Hz 920-920.7 Hz 961-961.7 Hz 963.8-964.25Hz 964.3-964.8 Hz
974.4-975 Hz 1156.3-1157 Hz 1157-1157.7 Hz 1755-1755.7 Hz 1873-1873.7 Hz
1967-1967.7 Hz 2017.4-2018 Hz 2021-2021.7 Hz 2023-2023.7 Hz 2035-2035.7 Hz
2053-2053.7 Hz 2065-2065.7 Hz 2083-2083.7 Hz 2094-2094.7 Hz 2111-2111.7 Hz
2128-2128.7 Hz 2278-2278.7 Hz 2284-2284.7 Hz 2308-2308.7 Hz 2324-2324.7 Hz
2338-2338.7 Hz 2362-2362.7 Hz 2381-2381.7 Hz 2419-2419.7 Hz 2425-2425.7 Hz
2430-2430.7 Hz 2431-2431.6 Hz 2471-2471.7 Hz 2480-2480.7 Hz 2522-2522.7 Hz
2636-2636.7 Hz 2669-2669.7 Hz 2679-2679.7 Hz 2685-2685.6 Hz 2716-2716.6 Hz
2743.4-2744 Hz 2835-2835.7 Hz 2854-2854.7 Hz 2865-2865.7 Hz 2873.3-2874 Hz
2886-2886.7 Hz 3009-3009.7 Hz 3020-3020.7 Hz 3042-3042.6 Hz 3076.3-3077 Hz
3104.3-3105 Hz 3135-3135.7 Hz 3143-3143.7 Hz 3160.4-3161 Hz 3167-3167.7 Hz
3206-3206.7 Hz 3255-3255.7 Hz 3267-3267.7 Hz 3269-3269.7 Hz 3330.4-3331 Hz
3516-3516.7 Hz 3531-3531.7 Hz 3549-3549.7 Hz 3564-3564.7 Hz 3572-3572.7 Hz
3576-3576.7 Hz 3619-3619.7 Hz 3630-3630.7 Hz 3637.7-3638.3 Hz 3644-3644.7 Hz
3696-3696.7 Hz 3749.3-3750 Hz 3947-3947.7 Hz 3954-3954.7 Hz 4013.4-4014 Hz
4079.4-4080 Hz 4123.4-4124 Hz 4281-4281.7 Hz 4289-4289.7 Hz 4312.4-4313 Hz
4418-4418.7 Hz 4426-4426.7 Hz 4441-4441.7 Hz 4685-4685.6 Hz 4707-4707.7 Hz
4715-4715.7 Hz 4732-4732.7 Hz 4732-4732.7 Hz 4748-4748.7 Hz 4767-4767.7 Hz
4812-4812.7 Hz 4821-4821.7 Hz 4873-4873.7 Hz 4874-4874.7 Hz 4876-4876.7 Hz
4941-4941.7 Hz 5209.4-5210 Hz 5229-5229.7 Hz 5243-5243.7 Hz 5247-5247.7 Hz
5262-5262.7 Hz 5271-5271.7 Hz 5387.3-5388 Hz 5573-5573.7 Hz 5671-5671.7 Hz
5679-5679.7 Hz 5966-5966.7 Hz 5976.3-5977 Hz 6064-6064.7 Hz 6086-6086.7 Hz
6180-6180.7 Hz 6479.4-6480 Hz 6513-6513.7 Hz 6711-6711.7 Hz 6779-6779.7 Hz
6915.3-6916 Hz 7019-7019.7 Hz 7043-7043.7 Hz 7130-7130.7 Hz 7213-7213.7 Hz
7228.3-7229 Hz 7234-7234.7 Hz 7246-7246.7 Hz 7268-7268.7 Hz 7367-7367.7 Hz
7482-7482.7 Hz 7510.4-7511 Hz 7680.3-7681 Hz 7862-7862.7 Hz 7935-7935.7 Hz
8012.3-8013 Hz 8013-8013.7 Hz 8026-8026.7 Hz 8028-8028.7 Hz 8028-8028.7 Hz
8055.4-8056 Hz 8072-8072.7 Hz 8074-8074.7 Hz 8079-8079.7 Hz 8141-8141.7 Hz
8336-8336.7 Hz 8394.3-8395 Hz 8421-8421.7 Hz 8432-8432.7 Hz 8452-8452.7 Hz
8492-8492.7 Hz 8509.4-8510 Hz 8542-8542.7 Hz 8779-8779.7 Hz 8789.3-8790 Hz
8818-8818.7 Hz 8852-8852.7 Hz 8993-8993.7 Hz 9023-9023.7 Hz 9112-9112.7 Hz
9332-9332.7 Hz 9753-9753.7 Hz 9846-9846.7 Hz 10140-10140.7 Hz 10317-10317.7 Hz
10362-10362.7 Hz 10488-10488.7 Hz 10661-10661.7 Hz 10665.4-10666 Hz 10690-10690.7 Hz
10866-10866.7 Hz 11081-11081.7 Hz 11109.3-11110 Hz 11219-11219.7 Hz 11582-11582.7 Hz
11619-11619.7 Hz 11637-11637.7 Hz 11802.3-11803 Hz 11809-11809.7 Hz 11831-11831.7 Hz
11872-11872.7 Hz 11904,3-11905 Hz 12024.3-12025 Hz 12228-12228.7 Hz 12247-12247.7 Hz
12260.4-12261 Hz 12274-12274.7 Hz 12682-12682.7 Hz 12752-12752.7 Hz 12783-12783.7 Hz
12785-12785.7 Hz 13127-13127.7 Hz 13457-13457.7 Hz 13609-13609.7 Hz 13734-13734.7 Hz
13747-13747.7 Hz 13755-13755.7 Hz 13760-13760.7 Hz 13761-13761.7 Hz 13767-13767.7 Hz
13981-13981.7 Hz 14005-14005.7 Hz 14027-14027.7 Hz 14070-14070.7 Hz 14078-14078.7 Hz
14356-14356.7 Hz 14531-14531.7 Hz 14545-14545.7 Hz 14564-14564.7 Hz 14828-14828.7 Hz
J 4867-14867.7 Hz 14913.4-14914 Hz 14940-14940.7 Hz 15173-15173.7 Hz 15224-15224.7 Hz
15244-15244.7 Hz 15432-15432.7 Hz 15460-15460.7 Hz 15515-15515.7 Hz 15539-15539.7 Hz
15550.4-15551 Hz 15857-15857.7 Hz 16082-16082.7 Hz 16515-16515.7 Hz 17636-17636.7 Hz
17673-17673.7 Hz 18087-18087.7 Hz 18222-18222.7 Hz 18521-18521.7 Hz 18585-18585.7 Hz
19347-19347.7 Hz 19889-19889.7 Hz 21466-21466.7 Hz 21567-21567.7 Hz 21844-21844.7 Hz
21870-21870.7 Hz 21894-21894.7 Hz 22073-22073.7 Hz 22119-22119.7 Hz 22411-22411.7 Hz
22437-22437.7 Hz 22479-22479.7 Hz 22582-22582.7 Hz 22730-22730.6 Hz 22832-22832.7 Hz
22863-22863.7 Hz 23237-23237.7 Hz 23261-23261.7 Hz 23444-23444.7 Hz 26212-26212.7 Hz
27291-27291.7 Hz 31051-31051.7 Hz 35296-35296.7 Hz 37680-37680.7 Hz 39053-39053.7 Hz
39183-39183.7 Hz 39423-39423.7 Hz 40111-40111.7 Hz 41557-41557.7 Hz 42293-42293.7 Hz
43172-43172.7 Hz 43379-43379.7 Hz 44855-44855.7 Hz 45163-45163.7 Hz 45362-45362.7 Hz
46666-46666.7 Hz 46673-46673.7 Hz 46689-46689.6 Hz 51008-51008.7 Hz 52063-52063.7 Hz
52786-52786.7 Hz 52912-52912.7 Hz 55723-55723.7 Hz 61287-61287.7 Hz 61789-61789.7 Hz
71635-71635.7 Hz 86521-86521.7 Hz 87798.3-87799 Hz 88898-88898.7 Hz 91271-91271.7 Hz
92787-92787.7 Hz.
[00127] Treatment of mesothelioma
[00128] Mesothelioma may be treated according to the methods disclosed herein by the application of mesothelioma spécifie amplitudc-modulated frequencies. Mesothelioma spécifie frequencies are provided below in Table 15. A patient suffering from mesothelioma may be treated with any number of the frequencies provided in Table 15, however it is generally préférable to empioy as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of the listed mesothelioma spécifie frequencies may be used in the treatment of mesothelioma. It should be noted that while the table below provides certain frequencies for treatment of mesothelioma, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of mesothelioma are within the scope of this disclosure. Furthermore, each of the frequencies listed below include values that are close to (i.e., within +/- 0.1 Hz), but not exactly, the number or range.
[00129] Table 15: Amplitude-modulated frequencies discovered to be effective for treatment of mesothelioma.
262-262.7 Hz 412-412.7 Hz 418-418.7 Hz 429-429.7 Hz 441-441.7 Hz
442-442.7 Hz 465-465.7 Hz 485-485.7 Hz 517-517.7 Hz 556-556.7 Hz
581-581.7 Hz 612-612.7 Hz 626-626.7 Hz 638-638.7 Hz 664-664.7 Hz
694.3-695 Hz 708.3-709 Hz 734.4-735 Hz 761-761.7 Hz 764-764.7 Hz
776-776.7 Hz 806-806.6 Hz 831-831.7 Hz 883-883.7 Hz 1191-1191.7 Hz
1591-1591.7 Hz 2475.4-2476 Hz 2581-2581.7 Hz 2749-2749.7 Hz 2988-2988.7 Hz
3042-3042.6 Hz 3131-3131.7 Hz 3193-3193.7 Hz 3240-3240.7 Hz 3335-3335.7 Hz
3371-3371.7 Hz 3518-3518.7 Hz 3523-3523.7 Hz 3530-3530.7 Hz 3556-3556.7 Hz
3621-3621.7 Hz 3656-3656.7 Hz 3674-3674.7 Hz 3681.7-3682.3 Hz 3817-3817.7 Hz
3833-3833.7 Hz 3877-3877.7 Hz 3948-3948.7 Hz 3958-3958.6 Hz 4044-4044.7 Hz
4190-4190.7 Hz 4261-4261.7 Hz 4330-4330.7 Hz 5496-5496.7 Hz 564Ü.4-5641 Hz
6416.3-6417 Hz 6441-6441.7 Hz 6717-6717.7 Hz 6758-6758.7 Hz 6783-6783.7 Hz
7110-7110.7 Hz 7140-7140.7 Hz 7154-7154.7 Hz 7156-7156.7 Hz 7253-7253.7 Hz
7283-7283.7 Hz 7546-7546.7 Hz 7725-7725.7 Hz 8386-8386.7 Hz 8562.4-8563 Hz
8810-8810.7 Hz 8827.4-8828 Hz 8843-8843.7 Hz 8859.3-8860 Hz 8863-8863.7 Hz
8877-8877.7 Hz 8881-8881.7 Hz 9075-9075.7 Hz 9929-9929.7 Hz 9947-9947.7 Hz
9970-9970.7 Hz 11023-11023.7 Hz 11031-11031.7 Hz H042-11042.7 Hz 11046-11046.7 Hz
11074-11074.7 Hz 11083-11083.7 Hz 11124-11124.7 Hz 11540-11540.7 Hz 11831-11831.7 Hz
11929-11929.7 Hz 11956-11956.7 Hz 12267-12267.7 Hz 12929-12929.7 Hz 13674-13674.7 Hz
13742-13742.7 Hz 14285-14285.7 Hz 14947-14947.7 Hz 15531-15531.7 Hz 17737-17737.7 Hz
17757-17757,7 Hz 18121-18121.7 Hz 18126-18126.7 Hz 18140-18140.7 Hz 18921-18921.7 Hz
19406-19406.7 Hz 19476-19476.7 Hz 19577-19577.7 Hz 20634-20634.7 Hz 21372-21372.7 Hz
22411-22411.7 Hz 22519-22519.7 Hz 22538-22538.7 Hz 22548-22548.7 Hz 23111-23111.7 Hz
23921-23921.7 Hz 24112-24112.7 Hz 24146-24146.7 Hz 39153-39153.7 Hz _______________________________________________-
[00130] In certain embodiments, the frequencies listed above may also be used in combination with one or more of the frequencies disclosed in the ‘365 patent, Specifically, treatment modalities for treatment of mesothelioma in accordance with this disclosure may include application of some 5 or ail of the above listed frequencies with one or more of the frequencies disclosed in the Table 16 for mesothelioma. Alternatively and/or additionally, the frequencies disclosed in the ‘365 patent may be used for treatment of mesothelioma using the methods and Systems described herein.
[00131] Table 16: Amplitude-modulated frequencies effective for treatment of mesothelioma.
958.929 Hz 1713.913 Hz 1736.782 Hz 2334.178 Hz 2607.193 Hz
3112.974 Hz 3319.945 Hz 3449.219 Hz 3622.312 Hz 5151.402 Hz ____
5887.022 Hz 5965.922 Hz 6516.793 Hz 7224.197 Hz 9471.152 Hz
14617.393 Hz
[00132] One or more of the AM frequencies of Table 15 may be used in combination with one or more of the frequencies provided in Table 16. In preferred embodiments, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more frequencies are used in the methods for the treatment of mesothelioma, which frequencies are selected from Table 15 and, optionally from Table 16, provided that at least one or more frequencies are selected from Table 15.
[00133] Treatment of thyroid cancer
[00134] Thyroid cancer may be treated according to the methods disclosed herein by the application of thyroid cancer spécifie amplitude-modulated frequencies. Thyroid cancer spécifie frequencies are provided below in Table 17. A patient suffering from thyroid cancer may be treated with any number of the frequencies provided in Table 17, however it is gcnerally préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of the listed thyroid cancer spécifie frequencies may be used in the treatment of thyroid cancer. It should be noted that while the table below provides certain frequencies for treatment of thyroid cancer, the disclosure is not so limiting, and other frequencies dîscovered to be effective in the treatment 15 of thyroid cancer are wilhin the scope of this disclosure. Furthermore, each of the frequencies listed below include values that are close to (i.e., witbin +/- 0.1 Hz), but not exactly, the number or range.
[00135] Table 17: Amplitude-modulated frequencies dîscovered to be effective for treatment of thyroid cancer.
834-834.7 Hz 836-836.7 Hz 845-845.7 Hz 1213-1213.7 Hz 1220-1220.7 Hz
1252-1252.7 Hz 1815-1815.7 Hz 1966-1966.7 Hz 2050-2050.7 Hz 2313-2313.7 Hz
2318-2318.7 Hz 2320-2320.7 Hz 2328-2328.7 Hz 2336-2336.7 Hz 2359-2359.7 Hz
2373-2373.7 Hz 2380-2380.7 Hz 2425-2425.7 Hz 2429-2429.7 Hz 2436-2436.7 Hz
2513-2513.7 Hz 2629-2629.7 Hz 2653.7-2654.4 Hz 2830-2830.7 Hz 2834-2834.7 Hz
3030-3030.7 Hz 3056-3056.7 Hz 3609-3609.7 Hz 3646-3646.7 Hz 3674-3674.7 Hz
3694-3694.7 Hz 3908.7-3909.22Hz 3981-3981.7 Hz 4027-4027.7 Hz 4386.4-4387 Hz
4425.7-4426.22Hz 4792-4792.7 Hz 4844-4844.7 Hz 4870-4870.7 Hz 5259-5259.7 Hz
5510-5510.7 Hz 5533-5533.7 Hz 5714-5714.7 Hz 5741-5741.7 Hz 5742-5742.7 Hz
5752-5752.7 Hz 5766-5766.7 Hz 6392-6392.7 Hz 6423-6423.7 Hz 6781-6781.7 Hz
6832-6832.7 Hz 6864-6864.7 Hz 7404.4-7405 Hz 7526-7526.6 Hz 7646-7646.7 Hz
7652-7652.7 Hz 7913-7913.7 Hz 8217.4-8218 Hz 8251-8251.7 Hz 8347-8347.7 Hz
8731-8731.7 Hz 8740-8740.7 Hz 8749-8749.7 Hz 8814-8814.7 Hz 9169-9169.7 Hz
9506-9506.7 Hz 10159-10159.7 Hz 10395-10395.7 Hz 10541-10541.7 Hz 10830-10830.7 Hz
10844-10844.7 Hz 10878-10878.7 Hz 10993-10993.7 Hz 11117-11117.7 Hz 11779-11779.7 Hz
11867-11867.7 Hz 12302-12302.7 Hz 12356-12356.7 Hz 13117-13117.7 Hz 13373-13373.7 Hz
13679-13679.7 Hz. 13694-13694.7 Hz 14111-14111.7 Hz 14116-14116.7 Hz 14156-14156.7 Hz
14174-14174.7 Hz 14281-14281.7 Hz 14523-14523.7 Hz 14585-14585.7 Hz 14690-14690.7 Hz
14716-14716.7 Hz 14912-14912.7 Hz 14974-14974.7 Hz 15223-15223.7 Hz 15236-15236.7 Hz
15329-15329.7 Hz 15615-15615.7 Hz 15867-15867.7 Hz 15919-15919.7 Hz 15942-15942.7 Hz
16096-16096.7 Hz 18040-18040.7 Hz 18182-18182.7 Hz 18211-18211.7 Hz 18246-18246.7 Hz
18274-18274.7 Hz 18411-18411.7 Hz 18454-18454.7 Hz 18462-18462.7 Hz 18596-18596.7 Hz
19365-19365.7 Hz 19419-19419.7 Hz 19715-19715.7 Hz 19744-19744.7 Hz 19823-19823.7 Hz
20229-20229.7 Hz 20284-20284.7 Hz 20513-20513.7 Hz 20747-20747.7 Hz 21963-21963.7 Hz
22338-22338.7 Hz 22344-22344.7 Hz 22350-22350.7 Hz 22422-22422.7 Hz 22484-22484.7 Hz
22932-22932.7 Hz 23012-23012.7 Hz 23044-23044,7 Hz 23216-23216.7 Hz 23659-23659.7 Hz
23730-23730.7 Hz 24060-24060.7 Hz 24085-24085.7 Hz 26044-26044.7 Hz 26343-26343,7 Hz
27214-27214.7 Hz 28361-28361.7 Hz 33366-33366.7 Hz 33414-33414.7 Hz 33553-33553.7 Hz
34614-34614.7 Hz 35826-35826.7 Hz 40133-40133.7 Hz 40394-40394.7 Hz 40896-40896.7 Hz
40899-40899.7 Hz 41424-41424.7 Hz 41534-41534.7 Hz 41859-41859.7 Hz 41861-41861.7 Hz
42402-42402.7 Hz 43851-43851.7 Hz 44162-44162.7 Hz 44692-44692.7 Hz 45393-45393.7 Hz
45526-45526.7 Hz 46282-46282.7 Hz 46285-46285.7 Hz 47036-47036.7 Hz 48314-48314.7 Hz
48535-48535.7 Hz 52097-52097.7 Hz 54293-54293.7 Hz 54297-54297.7 Hz 55592-55592.7 Hz
57927-57927.7 Hz 59907-59907.7 Hz 65586-65586.7 Hz 67697-67697.6 Hz 71204-71204.7 Hz
71447-71447.7 Hz 74017-74017.7 Hz 76227-76227.7 Hz 76659-76659.7 Hz 82024-82024.7 Hz
[00136] In certain embodiments, the frequencies listed above may also be used in combination with one or more of the frequencies disclosed in the ‘365 patent. Specîfically, treatment modalities for treatment of thyroid cancer in accordance with this disclosure may include application of some 5 or ail of the above listed frequencies with one or more of the frequencies disclosed in Table 18 for thyroid cancer. Altematively and/or additionally, the frequencies disclosed in the ‘365 patent may be used for treatment of thyroid cancer using the methods and Systems described herein.
[00137] Table 18: Amplitude-modulated frequencies for treatment of thyroid cancer.
410.231 Hz 412.209 Hz 479.222 Hz 493.442 Hz 517.202 Hz
556.233 Hz 617.313 Hz 618.407 Hz 618.813 Hz 618.927 Hz
621.321 Hz 628.321 Hz 648.252 Hz 658.191 Hz 663.407 Hz
694.689 Hz 777.432 Hz 812,512 Hz 814.251 Hz 820.907 Hz
821.202 Hz 831.223 Hz 874.341 Hz 914.429 Hz 941.311 Hz
942.331 Hz 983.429 Hz 1127.239 Hz 1191.341 Hz 1380.828 Hz
1552.123 Hz 1587.811 Hz 1614.409 Hz 1723.389 Hz 1771.402 Hz
2155.311 Hz 2179.231 Hz 2185.282 Hz 2221.323 Hz 2228.832 Hz
2315.888 Hz 2341.312 Hz 2445.123 Hz 2454.232 Hz 2723.302 Hz
2740.384 Hz 2749.323 Hz 2856.253 Hz 2856.921 Hz 2859.495 Hz
2871.795 Hz 2886.232 Hz 2928.911 Hz 2988.212 Hz 3021.122 Hz
3078.275 Hz 3080.592 Hz 3186.331 Hz 3198.323 Hz 3248.321 Hz
3271.329 Hz 3284.192 Hz 3335.332 Hz 3432.343 Hz 3434.911 Hz
3440.212 Hz 3475.216 Hz 3509.522 Hz 3533.328 Hz 3610.203 Hz
3637.085 Hz 3682.489 Hz 3789.288 Hz 3822.392 Hz 3909.333 Hz
3917.211 Hz 4023.33 Hz 4028.204 Hz 4043.332 Hz 4046.321 Hz
4154.301 Hz 4207.322 Hz 4226.263 Hz 4236.945 Hz 4243.393 Hz
4261.228 Hz 4330.289 Hz 4340.833 Hz 4347.125 Hz 4358.333 Hz
4366.294 Hz 4426.387 Hz 4440.962 Hz 4458.339 Hz 4478.443 Hz
4479.113 Hz 4486.193 Hz 4744.424 Hz 4827.642 Hz 4854.318 Hz
4865.421 Hz 4897.212 Hz 5323.192 Hz 5324.123 Hz 5548.879 Hz
5711.283 Hz 5730.432 Hz 5754.332 Hz 5881.295 Hz 5924.221 Hz
6455.131 Hz 6558.342 Hz 6620.132 Hz 6666.839 Hz 6675.951 Hz
6714.189 Hz 6745.333 Hz 6766.281 Hz 6779.088 Hz 6780.679 Hz
6884.432 Hz 6917.194 Hz 6946.928 Hz 7036.122 Hz 7083.191 Hz
7230.838 Hz 7323.209 Hz 7355.378 Hz 7432.143 Hz 7495.763 Hz
7505.282 Hz 7534.221 Hz 7577.421 Hz 7623.184 Hz 7626.332 Hz
7725.339 Hz 7726.085 Hz 7920.879 Hz 8013.953 Hz 8019.912 Hz
8021.331 Hz 8040.231 Hz 8078.955 Hz 8082.173 Hz 8147.1 Hz
8281.259 Hz 8309.752 Hz 8311.371 Hz 8435.094 Hz 8442.293 Hz
8505.312 Hz 8521.311 Hz 8525.789 Hz 8537.321 Hz 8540.329 Hz
8543.211 Hz 8553.329 Hz 8744.527 Hz 8881.819 Hz 9009.329 Hz
9068.311 Hz 9070.809 Hz 9085.911 Hz 9535.393 Hz 9720.412 Hz
10020.521 Hz 10039.109 Hz 10127.279 Hz 10134.161 Hz 10257.324 Hz
10498.339 Hz 10765.224 Hz 10849.412 Hz 10924.342 Hz 10976.321 Hz
11030.418 Hz 11360.332 Hz 11537.292 Hz 11559.292 Hz 11812.119 Hz
11913.222 Hz 11927.934 Hz 11955.949 Hz 11960.179 Hz 12120.049 Hz
12139.222 Hz 12146.335 Hz 12489.233 Hz 12984.462 Hz 13425.229 Hz
13636.082 Hz 13654.272 Hz 13677.211 Hz 14014.941 Hz 14228.295 Hz
14445.214 Hz 14540.932 Hz 14823.325 Hz 14826.334 Hz 14910.894 Hz
15180.492 Hz 15561.322 Hz 15597.284 Hz 16023.119 Hz 16048.391 Hz
16080.831 Hz 16129.321 Hz 16539.532 Hz 17222.225 Hz 17253.222 Hz
17323.196 Hz 17461.504 Hz 17577.221 Hz 17671.321 Hz 17881.709 Hz
17911.323 Hz 17913.286 Hz 17937.203 Hz 17948.264 Hz 18036.921 Hz
18715.412 Hz 19859.429 Hz 21425.321 Hz 21452.445 Hz
[00138] One or more of the AM frequencies of Table 17 may be used in combination with one or more of the frequencies provided in Table 18. In preferred embodiments, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 5 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more frequencies are used in the methods for the treatment of thyroid cancer, which frequencies are selected from Table 17 and, optionally from Table 18, provided that at least one or more frequencies are selected from Table 17.
[00139] Treatment of prostate cancer
[00140] Prostate cancer may be treated according to the methods disclosed herein by the application of prostate cancer spécifie amplitude-modulated frequencies. Prostate cancer spécifie frequencies are provided below in Table 19. A patient suffering from prostate cancer may be 5 treated with any number of the frequencies provided in Table 19, however it is generally préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of the listed prostate cancer spécifie frequencies may be used in the treatment of prostate cancer. It should 10 be noted that while the table below provides certain frequencies for treatment of prostate cancer, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of prostate cancer are within the scope of this disclosure. Furthermore, each of the frequencies listed below include values that are close to (i.e., within +/- 0.1 Hz), but not exactly, the number or range.
[00141] Table 19: Amplitude-modulated frequencies discovered to be effective for treatment of prostate cancer.
408-408.7 Hz 429.7-430.3 Hz 561-561.7 Hz 568-568.7 Hz 572-572.7 Hz
631-631.7 Hz 709-709.7 Hz 717-717.7 Hz 733-733.7 Hz 810-810.7 Hz
817-817.7 Hz 830-830.7 Hz 1668-1668.7 Hz 1808-1808.6 Hz 2483-2483.7 Hz
2518-2518.7 Hz 2824-2824.7 Hz 3207-3207.7 Hz 3245-3245.7 Hz 3251-3251.7 Hz
3266.3-3267 Hz 3279.3-3280 Hz 3529-3529.7 Hz 3562-3562.7 Hz 3571-3571.7 Hz
3627-3627.7 Hz 3661-3661.7 Hz 3731-3731.7 Hz 3743-3743.7 Hz 3756-3756.7 Hz
3787-3787.7 Hz 3962-3962.7 Hz 4152-4152.7 Hz 4409-4409.7 Hz 4476-4476.7 Hz
4806-4806.7 Hz 4809-4809.7 Hz 4823-4823.7 Hz 4841-4841.7 Hz 4948-4948.7 Hz
4998-4998.7 Hz 5336-5336.7 Hz 5414-5414.7 Hz 5884-5884.7 Hz 6117-6117.7 Hz
6252-6252.7 Hz 6329-6329.7 Hz 6333-6333.7 Hz 6748-6748.7 Hz 6782-6782.7 Hz
7112-7112.7 Hz 7424-7424.7 Hz 7655-7655.7 Hz 7906-7906.7 Hz 7910-7910.7 Hz
7923-7923.7 Hz 8373-8373.7 Hz 8445-8445.7 Hz 8765-8765.7 Hz 8829-8829.7 Hz
8852-8852.7 Hz 8877-8877.7 Hz 9078-9078.7 Hz 9512-9512.7 Hz 9635-9635.7 Hz
9681-9681.7 Hz 9886-9886.7 Hz 10735-10735.7 Hz 10748-10748.7 Hz 10781-10781.7 Hz
10813.2-10813.8 Hz 11134-11134.7 Hz 11155-11155.7 Hz 11164-11164.7 Hz 11264-11264.7 Hz
11381-11381.7 Hz 11416-11416.7 Hz 11438-11438.7 Hz 11469-11469.7 Hz 11628-11628.7 Hz_
12330-12330.7 Hz 12391-12391.7 Hz 12880-12880.7 Hz 13467-13467.7 Hz 13562-13562.6 Hz_
13805-13805.7 Hz 13828-13828.7 Hz 13834-13834.7 Hz 13857.4-13858 Hz 13858-13858.7 Hz
13871-13871.7 Hz 14009-14009.7 Hz 14034-14034.7 Hz 14153-14153.7 Hz 14489-14489.7 Hz
15071-15071.7 Hz 15149-15149.7 Hz 15233-15233.7 Hz 15253-15253.7 Hz 15263-15263.7 Hz
15435-15435.7 Hz 15545-15545.7 Hz 16176-16176.7 Hz 16329-16329.7 Hz 16679-16679.7 Hz
16804-16804.7 Hz 16821-16821.7 Hz 17333-17333.7 Hz 17435-17435.7 Hz 17974-17974.7 Hz
18260-18260.7 Hz 18641-18641.7 Hz 18831-18831.7 Hz 18884-18884.7 Hz 19453-19453.7 Hz
20948-20948.7 Hz 21119-21119.7 Hz 21167-21167.7 Hz 21636-21636.7 Hz 22312-22312.7 Hz
22361-22361.7 Hz 22419-22419.7 Hz 22430-22430.7 Hz 22443-22443.7 Hz 22459-22459.7 Hz
22879-22879.7 Hz 23117-23117.7 Hz 23137-23137.7 Hz 23412-23412.7 Hz 23548-23548.7 Hz
23686-23686.7 Hz 26142-26142.7 Hz 26465-26465.7 Hz 27328-27328.6 Hz 28653-28653.7 Hz
28744-28744.7 Hz 31572-31572.7 Hz 31633-31633.7 Hz 41062-41062.7 Hz 41325-41325.7 Hz
41473-41473.7 Hz 48683-48683.7 Hz 48793-48793.7 Hz 87507-87507.7 Hz
[00142] In certain embodiments, the frequencies listed above may also be used in combination with one or more of the frequencies dîsclosed in the ‘365 patent. Specifically, treatment modalities for treatment of prostate cancer in accordance with this disclosure may include application of some or ail of the above listed frequencies with one or more of the frequencies dîsclosed in Table 20 for prostate cancer. Alternatively and/or additionally, the frequencies dîsclosed in the ‘365 patent may be used for treatment of prostate cancer using the methods and Systems described herein.
[00143] Table 20: Amplitude-modulated frequencies for treatment of prostate cancer.
331.3 Hz 331.358 Hz 403.218 Hz 430.439 Hz 436.231 Hz
461.233 Hz 522.2 Hz 522.213 Hz 618.4 Hz 618.407 Hz
618.8 Hz 656.295 Hz 657.394 Hz 657.397 Hz 657.4 Hz
657.483 Hz 659.033 Hz 694.4 Hz 694.689 Hz 694.7 Hz
741.4 Hz 741.421 Hz 749.221 Hz 752.9 Hz 752.933 Hz
776.194 Hz 785.219 Hz 786.332 Hz 793.331 Hz 809.205 Hz
819.322 Hz 840.133 Hz 844.8 Hz 844.822 Hz 847.332 Hz
929.1 Hz 1083.309 Hz 1102.635 Hz 1102.71 Hz 1240.336 Hz
1372.934 Hz 1444.288 Hz 1486.322 Hz 1563.332 Hz 1591.322 Hz
1670.699 Hz 1697.321 Hz 1708.195 Hz 1741.939 Hz 1743.521 Hz
2031.448 Hz 2050.282 Hz 2076.519 Hz 2156.332 Hz 2229.515 Hz
2243.121 Hz 2381.443 Hz 2440.489 Hz 2475.912 Hz 2477.919 Hz
2551.332 Hz 2579.435 Hz 2628.324 Hz 2669.328 Hz 2824.832 Hz
2887.829 Hz 2891.331 Hz 3081.523 Hz 3133.309 Hz 3249.529 Hz
3250.125 Hz 3251.815 Hz 3264.827 Hz 3278.329 Hz 3281.432 Hz
3348.783 Hz 3519.118 Hz 3539.962 Hz 3551.318 Hz 3556.439 Hz
3572.321 Hz 3615.223 Hz 3670.129 Hz 3681.341 Hz 3686.021 Hz
3753.382 Hz 3774.923 Hz 3867.692 Hz 3909.333 Hz 3916.321 Hz
4031.233 Hz 4031.933 Hz 4038.203 Hz 4047.233 Hz 4066.222 Hz
4081.743 Hz 4084.319 Hz 4139.322 Hz 4153.192 Hz 4223.795 Hz
4231.221 Hz 4241.321 Hz 4320.513 Hz 4329.152 Hz 4380.321 Hz
4417.312 Hz 4489.452 Hz 4549.808 Hz 4558.306 Hz 4579.324 Hz
4638.293 Hz 4740.322 Hz 4854.318 Hz 4882.322 Hz 4978.822 Hz
5237.152 Hz 5264.222 Hz 5289.195 Hz 5426.323 Hz 5431.542 Hz
5455.593 Hz 6168.131 Hz 6345.332 Hz 6347.433 Hz 6363.284 Hz
6418.331 Hz 6496.231 Hz 6538.295 Hz 6577.421 Hz 6590.328 Hz
6651.276 Hz 6706.431 Hz 6743.322 Hz 6783.282 Hz 6850.197 Hz
6855.286 Hz 6864.896 Hz 6871.943 Hz 6878.356 Hz 6898.489 Hz
6973.393 Hz 7118.332 Hz 7120.932 Hz 7143.231 Hz 7146.509 Hz
7192.505 Hz 7251.309 Hz 7251.322 Hz 7278.124 Hz 7278.933 Hz
7279.335 Hz 7299.119 Hz 7527.229 Hz 7589.925 Hz 7699.193 Hz
7832.331 Hz 7842.184 Hz 7852.393 Hz 7872.333 Hz 8023.32 Hz
8096.939 Hz 8245.801 Hz 8315.291 Hz 8357.305 Hz 8408.121 Hz
8432.209 Hz 8535.238 Hz 8552.431 Hz 8585.224 Hz 8923.361 Hz
8935.752 Hz 9015.253 Hz 9018.233 Hz 9068.231 Hz 9137.232 Hz
9156.321 Hz 9351.931 Hz 9393.946 Hz 9694.179 Hz 9984.405 Hz
10226.223 Hz 10390.232 Hz 10442.221 Hz 10449.343 Hz 10459.084 Hz
10514.768 Hz 10651.311Hz 10689.339 Hz 10772.419 Hz 10818.452 Hz
10843.543 Hz 11118.322 Hz 11165.239 Hz 11985.353 Hz 12209.329 Hz
12308.321 Hz 12489.233 Hz 12583.339 Hz 13820.329 Hz 14013.123 Hz
14129.213 Hz 14171.434 Hz 14681.329 Hz 14759.131 Hz 14986.794 Hz
15930.249 Hz 16026.623 Hz 16888.912 Hz 17091.189 Hz 17880.954 Hz
18021.222 Hz 18053.233 Hz 18247.532 Hz 18282.211 Hz 18610.232 Hz
18629.328 Hz. 19469.318 Hz 19766.218 Hz 20159.434 Hz 21643.232 Hz
23022.481 Hz 23035.132 Hz 26718.23 Hz 30583.383 Hz 30653.323 Hz
30843.222 Hz 36065.221 Hz 60317.352 Hz
[00144] One or more of the AM frequencies of Table 19 may be used in combination with one or more of the frequencies provided in Table 20. In preferred embodiments, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 5 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more frequencies are used in the methods for the treatment of prostate cancer, which frequencies are selected from Table 19 and, optionally from Table 20, provided that at least one or more frequencies are selected from Table 19.
[00145] Treatment of rhabdomyosarcoma
[00146] Rhabdomyosarcoma may be treated according to the methods disclosed herein by the application of rhabdomyosarcoma spécifie amplitude-modulated frequencies. Rhabdomyosarcoma spécifie frequencies are provided below in Table 21. A patient suffering from rhabdomyosarcoma may be treated with any number of the frequencies provided in Table 21, however it is generally préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of the listed rhabdomyosarcoma spécifie frequencies may be used in the treatment of rhabdomyosarcoma. It should be noted that while the table below provides certain
frequencies for treatment of rhabdomyosarcoma, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of rhabdomyosarcoma are within the scope of this disclosure. Furthermore, each of the frequencies listed below include values thaï are close to (i.e., within +/- 0.1 Hz), but not exaclly, the number or range.
[00147] Table 21: Amplitude-modulated frequencies discovered to be effective for treatment of rhabdomyosarcoma.
304-304.7 Hz 331-331.7 Hz 410-410.7 Hz 420-420.7 Hz 429-429.7 Hz
434-434.7 Hz 461-461.7 Hz 537.4-538 Hz 560-560.7 Hz 572-572.7 Hz
605-605.7 Hz 611-611.7 Hz 618.3-619 Hz 626-626.7 Hz 717-717.7 Hz
776-776.7 Hz 779-779.7 Hz 810-810.7 Hz 814-814.7 Hz 826-826.7 Hz
836.4-837 Hz 843-843.7 Hz 843-843.7 Hz 1314-1314.7 Hz 1411-1411.7 Hz
1467-1467.7 Hz 1785-1785.7 Hz 1816-1816.7 Hz 1903-1903.7 Hz 2073.3-2074 Hz
2155-2155.7 Hz 2287-2287.7 Hz 2381-2381.7 Hz 2542-2542.7 Hz 2711-2711.6 Hz
2854-2854.6 Hz 2911-2911.7 Hz 3085.7-3086.3 Hz 3121-3121.7 Hz 3232-3232.7 Hz
3438-3438.7 Hz 3518-3518.7 Hz 3544-3544.7 Hz 3569-3569.7 Hz 3618-3618.7 Hz
3910-3910.7 Hz 3917-3917.7 Hz 4198-4198.7 Hz 4233.3-4234 Hz 4241-4241.7 Hz
266.3-267 Hz 4337-4337.7 Hz 4358-4358.7 Hz 4424-4424.7 Hz 4436-4436.7 Hz
4485-4485.7 Hz 4731-4731.7 Hz 4749-4749.7 Hz 4776-4776.7 Hz 5151-5151.7 Hz
5521-5521.7 Hz 5545.3-5546 Hz 5577.3-5578 Hz 5618-5618.7 Hz 5631-5631.7 Hz
5696-5696.7 Hz 6058-6058.7 Hz 6443-6443.7 Hz 6472-6472.6 Hz 6558-6558.7 Hz
6651-6651.7 Hz 6730-6730.7 Hz 7168.4-7169 Hz 7406-7406.7 Hz 7440-7440.7 Hz
7452.3-7453 Hz 7649-7649.7 Hz 7808-7808.7 Hz 8542-8542.7 Hz 8546-8546.7 Hz
8562-8562.7 Hz 8576-8576.7 Hz 8698-8698.7 Hz 8881-8881.7 Hz 9040-9040.7 Hz
9074-9074.7 Hz 9189-9189.6 Hz 9484.3-9485 Hz 9851-9851.7 Hz 9943,4-9944 Hz
10870-10870.7 Hz 10891-10891.7 Hz 12086-12086.7 Hz 12648-12648.7 Hz 15195-15195.7 Hz
17316-17316.7 Hz 18021-18021.7 Hz 18567-18567.7 Hz 19384-19384.7 Hz 20097-20097.7 Hz
20278.4-20279 Hz 21854-21854.7 Hz 21890-21890.7 Hz 24198-24198.7 Hz 24413-24413.7 Hz
24789-24789.7 Hz 26534-26534.7 Hz 27713-27713.7 Hz 28222-28222.7 Hz 40489-40489.7 Hz
40762-40762.7 Hz 41279-41279.7 Hz 42923-42923.7 Hz 43166-43166.7 Hz 43692-43692.7 Hz
48583-48583.7 Hz 49434-49434.7 Hz 66553-66553.7 Hz 79658-79658.7 Hz ___
[00148] Treatment of colorectal cancer
[00149] Colorectal cancer may be treated according to the methods disclosed herein by the application of colorectal cancer spécifie amplitude-modulated frequencies. Colorectal cancer spécifie frequencies are provided below in Table 22. A patient suffering from colorectal cancer may be treated with any number of the frequencies provided in Table 22, however it is generally préférable to empioy as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 15 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of the listed colorectal cancer spécifie frequencies may be used in the treatment of colorectal cancer. It should be noted that while the table below provides certain frequencies for treatment of colorectal cancer, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of colorectal cancer are within the scope of this disclosure. Furthermore, each of 5 the frequencies listed below include values that are close to (i.e., within +/- 0.1 Hz), but not exactly, the number or range.
[00150] Table 22: Amplitude-modulated frequencies discovered to be effective for treatment of colorectal cancer.
605-605.7 Hz 826-826.7 Hz 834-834.7 Hz 841.9-842.6 Hz 1808-1808.6 Hz
1928-1928.7 Hz 1989-1989.7Hz 2439.7-2440.3Hz 2714-2714.7 Hz 2747-2747.7 Hz
2759-2759.7 Hz 2807-2807.7 Hz 2826-2826.7 Hz 2981-2981.7 Hz 3209-3209.7 Hz
3213-3213.7 Hz 3244-3244.7 Hz 3261-3261.7 Hz 3548-3548.7 Hz 3634-3634.7 Hz___
3646.4-3647 Hz 3915-3915.7 Hz 3922-3922.7 Hz 3940-3940.7 Hz 3946-3946.7 Hz
4135-4135.7 Hz 4155-4155.7 Hz 4224-4224.7 Hz 4241-4241.7 Hz 4283-4283.7 Hz
4323-4323.7 Hz 4438.7-4439.2Hz 4447-4447.7 Hz 4708-4708.7 Hz 4713-4713.7 Hz
4718-4718.7 Hz 4718-4718.7 Hz 4722-4722.7 Hz . 4776-4776.7 Hz 4850-4850.7 Hz
4874-4874.7 Hz 5205-5205.7 Hz 5209-5209.7 Hz 5209-5209.7 Hz 5221-5221.7 Hz
5232-5232.7 Hz 5265-5265.7 Hz 5427-5427.7 Hz 5484.4-5485 Hz 6074-6074.7 Hz
6112-6112.7 Hz 6159-6159.7 Hz 6361-6361.7 Hz 6438-6438.7 Hz 6468-6468.7 Hz
6537-6537.7 Hz 6648-6648.7 Hz 6869-6869.7 Hz 6878-6878.7 Hz 6914-6914,7 Hz
6974-6974.7 Hz 6982-6982.7 Hz 6986-6986.7 Hz 7109-7109.7 Hz 7117-7117.7 Hz
7137-7137.7 Hz 7149-7149.7 Hz 7191.7-7192.3Hz 7531-7531.7 Hz 7560-7560.7 Hz
7879-7879.7 Hz 7936-7936.7 Hz 7970-7970.7 Hz 7994-7994.7 Hz 8038.4-8039 Hz
8413-8413.7 Hz 8438-8438.7 Hz 8467-8467.7 Hz 8771-8771.7 Hz 8809-8809.7 Hz
8889-8889.7 Hz 9071-9071.7 Hz 9084-9084.7 Hz 9731-9731.7 Hz 10566-10566.7 Hz
10831.7-10832.1 Hz 10845-10845.7 Hz 10859-10859.7 Hzl 10906-10906.7 Hz 10947-10947.7 Hz
10974-10974.7 Hz 11110-11110.7 Hz 11225-11225.7 Hz 11234-11234.7 Hz 11255-11255.7 Hz
11387-11387.7 Hz 11530-11530.7 Hz 11576-11576.7 Hz 11621-11621.7 Hz 11630-11630.7 Hz
11638-11638.7 Hz 11681-11681.7 Hz 11911-11911.7 Hz 11934-11934.7 Hz 11949-11949.7 Hz
12182-12182.7 Hz 12373-12373.7 Hz 12575-12575.7 Hz 12589-12589.7 Hz 12617-12617.7 Hz
12629-12629.7 Hz 12637-12637.7 Hz 12645-12645.7 Hz 13418-13418.7 Hz_ 13475-13475.7 Hz
13611-13611.7 Hz 13615-13615.7 Hz 13670-13670.7 Hz 13717-13717.7 Hz 13736-13736.7 Hz
13742-13742.7 Hz 13773-13773.7 Hz 13775-13775.7 Hz 13978.3-13979 Hz_ 14182-14182.7 Hz
14417-14417.7 Hz 14422-14422.7 Hz 14441-14441.7 Hz 14443-14443.7 Hz 14570-14570.7 Hz
14621-14621.7 Hz 14630-14630.7 Hz 14671-14671.7 Hz 14674-14674.7 Hz 14863-14863.7 Hz
14877-14877.7 Hz 14911-14911.7 Hz 14957-14957.7 Hz 14982-14982.7 Hz 15109-15109.7 Hz
15133-15133.7 Hz 15154-15154.7 Hz 15230-15230.7 Hz 15250-15250.7 Hz 15278-15278.7 Hz
16274-16274.7 Hz 17106-17106.7 Hz 17123-17123.7 Hz 17472-17472.7 Hz 17515-17515.7 Hz
17578.4-17579 Hz 17808-17808.7 Hz 17825-17825.7 Hz 18157-18157.7 Hz 18171-18171.7 Hz
18294-18294.7 Hz 18372-18372.7 Hz 18375-18375.7 Hz 18396-18396.7 Hz 18533-18533.7 Hz
18635-18635.7 Hz 19342-19342.7 Hz 19437-19437.7 Hz 19447-19447.7 Hz 19829-19829.7 Hz
20173-20173.7 Hz 20499-20499.7 Hz 21389-21389.7 Hz 21490-21490.7 Hz Γ21663-21663.7 Hz
21833-21833.7 Hz 22167-22167.7 Hz 22423.4-22424 Hz 22559.3-22560 Hz 22743-22743.7 Hz
23246-23246.7 Hz 23249-23249.7 Hz 23259-23259.7 Hz 23344-23344.7 Hz 23624-23624.7 Hz
23667-23667.7 Hz 24142-24142.7 Hz 26113-26113.7 Hz 26403-26403.7 Hz 28212-28212.7 Hz
28272-28272.7 Hz 28537-28537.7 Hz 30075-30075.7 Hz 30373-30373.7 Hz 31847-31847.7 Hz
33546-33546.7 Hz 35324-35324.7 Hz 35543-35543.7 Hz 42544-42544.7 Hz 42692.3-42693 Hz
42812-42812.7 Hz 42813-42813.7 Hz 43162-43162.7 Hz 43325-43325.7 Hz 44652-44652.7 Hz
46340-46340.7 Hz 46746-46746.7 Hz 48653-48653.7 Hz 51946-51946.7 Hz 52752-52752.7 Hz
80715-80715.7 Hz 94494-94494.7 Hz
[00151] In certain embodiments, the frequencies listed above may also be used in combination with one or more of the frequencies disclosed in the ‘365 patent (reproduced below). Specifically, treatment modalities for treatment of colorectal cancer in accordance with this disclosure may include application of some or ali of the above listed frequencies with one or more of the frequencies disclosed in Table 23 for colorectal cancer. Alternatively and/or addilionally, the frequencies disclosed in the ‘365 patent may be used for treatment of colorectal cancer using the methods and Systems described herein.
[00152] Table 23; Amplitude-modulated frequencies for treatment of colon cancer.
78.76 Hz 796.562 Hz 841.541 Hz 842.783 Hz 914.429 Hz
1162.117 Hz 1372.207 Hz 1372.934 Hz 1718.532 Hz 2243.169 Hz
2278.312 Hz 2286.5 Hz 2286.519 Hz 2334.178 Hz 2423.292 Hz
2454.423 Hz 2464.229 Hz 2598.853 Hz 2623,048 Hz 3131.123 Hz_____
3161.465 Hz 3175.313 Hz 3249.529 Hz 3363.229 Hz 3373.892 Hz
3390.925 Hz 3409.179 Hz 3432.274 Hz 3509.522 Hz 3531.422 Hz
3533.328 Hz 3766.296 Hz 4040.839 Hz 4081.022 Hz 4123.953 Hz
4146.274 Hz 4233.822 Hz 4282.332 Hz 4318.222 Hz 4344.082 Hz
4416.221 Hz 4481.242 Hz 4724.263 Hz 4751.319 Hz 4755.323 Hz
4788.485 Hz 5149.331 Hz 5217.402 Hz 5386.212 Hz 5407.192 Hz_____
5426.323 Hz 5496.434 Hz Ί 5555.212 Hz 5572.032 Hz 5634.933 Hz
5724.231 Hz 5758.378 Hz 5787.342 Hz. 5948.897 Hz 5967.448 Hz __
5976.825 Hz 6182.322 Hz 6292.379 Hz 6324.493 Hz 6341.248 Hz
6471.322 Hz 6477.218 Hz 6558.342 Hz 6855.286 Hz 7129.843 Hz
7140.187 Hz 7162.422 Hz 736S.222 Hz 7645.859 Hz 7829.234 Hz
7866.229 Hz 7877.334 Hz 8013.314 Hz 8374.942 Hz 8384.228 Hz
8408.121 Hz 8534.111 Hz 8568.033 Hz 8573.122 Hz 9226,222 Hz
9351.9 Hz 9737.211 Hz 9744.193 Hz 9942.321 Hz 10301.371 Hz____
10401.515 Hz 10872.693 Hz 11220.222 Hz 11283.378 Hz 12256.432 Hz
13749.858 Hz 15231.548 Hz 15248.324 Hz 58191.928 Hz 60317.352 Hz
[00153] One or more of the AM frequencies of Table 22 may be used in combination with one or more of the frequencies provided in Table 23. In preferred embodiments, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, or more, 70 or more, 80 or more, 90 or more, or 100 or more frequencies are used in the methods for the treatment of colorectal cancer, which frequencies are selected from Table 22 and, optionally from Table 23, provided that at least one or more frequencies are selected from Table 22.
[00154] In certain embodiments, the frequencies disclosed in the ‘365 patent may be used for 5 treatment of a diseased State using the methods and Systems described herein.
[00155] Treatment of ovarian cancer
[00156] Ovarian cancer may be treated according to the methods disclosed herein by the application of ovarian cancer spécifie amplitude-modulated frequencies. Ovarian cancer spécifie frequencies are provided below in Table 24. A patient suffering from ovarian cancer may be 10 treated with any number of the frequencies provided in Table 24, however it is generaliy préférable to eniploy as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of the listed ovarian cancer spécifie frequencies may be used in the treatment of ovarian cancer. It shouid 15 be noted that while the table below provides certain frequencies for treatment of ovarian cancer, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of ovarian cancer are within the scope of this disclosure.
[00157] Table 24: Amplitude-modulated frequencies for treatment of ovarian cancer.
78.76 Hz 181.821 Hz 367.211 Hz 403.218 Hz 410.245 Hz
414.817 Hz 436.332 Hz 447.942 Hz 481.191 Hz 489.292 Hz
537.914 Hz 559.292 Hz 608.321 Hz 618.407 Hz 621.321 Hz
655.435 Hz 657.394 Hz 657.397 Hz 657.483 Hz 664.211 Hz
694.689 Hz 708.787 Hz 708.8 Hz 708.821 Hz 708.822 Hz
734.921 Hz 749.221 Hz 764.232 Hz 778.295 Hz 779.403 Hz
806.021 Hz 806.389 Hz 809.313 Hz 824.327 Hz 825.145 Hz
835.129 Hz 839.521 Hz. 841.208 Hz 843.312 Hz 925.309 Hz
956.984 Hz 958.929 Hz 985.313 Hz 1024.208 Hz 1102.635 Hz
1121.329 Hz 1159.738 Hz. 1221.321 Hz 1372.207 Hz 1396.498 Hz
1502.181 Hz 1518.208 Hz 1552.123 Hz 1579.212 Hz 1624.802 Hz
1656.431 Hz 1670.699 Hz 1679.432 Hz 1696.403 Hz 1759.318 Hz
1762.938 Hz 1771.402 Hz 1775.313 Hz 1821.729 Hz 1990.482 Hz
2016.323 Hz 2031.448 Hz 2034.231 Hz 2050.282 Hz 2053.396 Hz
2082.234 Hz 2089.092 Hz 2221.323 Hz 2228.832 Hz 2229.515 Hz
2253.704 Hz 2254.329 Hz 2278.312 Hz 2332.949 Hz 2348.233 Hz
2381.443 Hz 2413.193 Hz 2415.243 Hz 2425.222 Hz 2433.321 Hz
2439.253 Hz 2465.23 Hz 2477.919 Hz 2669.177 Hz 2715.232 Hz
2733.843 Hz 2771.211 Hz 2802.339 Hz 2812.321 Hz 2831.386 Hz
2835.332 Hz 2851.347 Hz 2856.253 Hz 2873.542 Hz 2877.192 Hz
2885.322 Hz 2887.385 Hz 2894.972 Hz 2973.771 Hz 3080.592 Hz
3157.483 Hz 3160.321 Hz 3161.465 Hz 3185.129 Hz 3223.232 Hz
3238.148 Hz 3240.111 Hz 3249.529 Hz 3254.122 Hz 3262.145 Hz
3264.241 Hz 3265.121 Hz 3282.235 Hz 3283.392 Hz 3296.431 Hz
3314.321 Hz 3361.671 Hz 3366.311 Hz 3459.408 Hz 3461.322 Hz
3523.215 Hz 3527.233 Hz 3542.213 Hz 3590.376 Hz 3629.232 Hz
3632.793 Hz 3636.289 Hz 3637.085 Hz 3669,513 Hz 3770.189 Hz,
3858.916 Hz 3872.321 Hz 3919.232 Hz 3941.739 Hz 3957.185 Hz
3975.228 Hz 3975.383 Hz 4061.131 Hz 4072.322 Hz 4139.322 Hz
4169.451 Hz 4174.259 Hz 4241.321 Hz 4243.393 Hz 4261.228 Hz
4279.113 Hz 4309.335 Hz 4314.188 Hz 4318.222 Hz 4328.928 Hz
4340.833 Hz 4380.321 Hz 4394.134 Hz 4412.252 Hz 4424.236 Hz
4439.341 Hz 4442.161 Hz 4447.221 Hz 4458.339 Hz 4556.322 Hz
4566.009 Hz 4579.981 Hz 4682.643 Hz 4718.331 Hz 4749.302 Hz
4765.331 Hz 4779.194 Hz 4912.923 Hz 4917.202 Hz 5011.325 Hz
5149.331 Hz 5228.172 Hz 5237.132 Hz 5313.353 Hz 5745.218 Hz
5757.897 Hz 5762.386 Hz 5812.322 Hz 5869.321 Hz 5882.292 Hz
5921.249 Hz 5991.932 Hz 6069.458 Hz 6071.319 Hz 6083.214 Hz
6111.819 Hz 6161.782 Hz 6169.341 Hz 6275.232 Hz 6294.929 Hz
6350.333 Hz 6356.321 Hz 6406.891 Hz 6407.207 Hz 6450.787 Hz
6477.098 Hz 6477.929 Hz 6478.338 Hz 6504,983 Hz 6543.421 Hz
6552.24 Hz 6661.09 Hz 6663.955 Hz 6753.338 Hz 6789.211 Hz
6851.323 Hz 6855.286 Hz 6875.232 Hz 6882.949 Hz 7047.223 Hz
7206.403 Hz 7232.214 Hz 7257.489 Hz 7276.209 Hz 7279.335 Hz
7281,219 Hz 7285.223 Hz 7285.693 Hz 7289.192 Hz 7326.229 Hz
7399.223 Hz 7429.212 Hz 7460.932 Hz 7480.228 Hz 7488.742 Hz
7495.763 Hz 7539.432 Hz 7564.185 Hz 7650.028 Hz 7689.728 Hz
7780.294 Hz 8021.921 Hz 8038.961 Hz 8040.322 Hz 8044.233 Hz
8054,413 Hz 8095.313 Hz 8141.174 Hz 8143.491 Hz 8164,332 Hz
8261.121 Hz 8302.285 Hz 8309.752 Hz 8372.532 Hz 8408.121 Hz
8424.229 Hz 8428.313 Hz 8430.142 Hz 8435.451 Hz 8486.421 Hz
8492.797 Hz 8548.324 Hz 8554.361 Hz 8562.965 Hz 8578.193 Hz
8579.323 Hz 8579.333 Hz 8597.409 Hz 8642.181 Hz 8655.818 Hz
8758.341 Hz 8779.323 Hz 8792.231 Hz 8819.127 Hz 8831.132 Hz
8863.232 Hz 9028.031 Hz 9049.205 Hz 9173.264 Hz 9175.311 Hz
9184.338 Hz 9186.919 Hz 9393.946 Hz 9482.409 Hz 9658.296 Hz
9737.21 ( Hz 9746.232 Hz 9859.322 Hz 9922,231 Hz 10020.213 Hz
10032.684 Hz 10435.191 Hz 10446.028 Hz 10449.221 Hz 10457,329 Hz
10478.221 Hz 10498.339 Hz 10545.313 Hz 10639,345 Hz 10720.221 Hz
10743.118 Hz 10813.981 Hz 10832.421 Hz 10838.243 Hz 10862.429 Hz
10865.127 Hz 10917.229 Hz 10977.188 Hz 11120.209 Hz 11143.409 Hz
11177.289 Hz 11177.409 Hz 11321.491 Hz 11359.093 Hz 11540.212 Hz
11673.031 Hz 11731.295 Hz 11793.886 Hz 11895.229 Hz 12074.531 Hz
12216.212 Hz 12223.329 Hz 12243.132 Hz 12253.329 Hz 12260.933 Hz
2262.853 Hz 12292.222 Hz 12357.353 Hz 12527.032 Hz 12668,194 Hz
12743.197 Hz 12755.333 Hz 12947.311 Hz 13477.293 Hz 13582,122 Hz
13636.082 Hz 13717.221 Hz 13756.503 Hz 13825.295 Hz 13829.195 Hz
14188.61 f Hz 14410.949 Hz 14436.201 Hz 14528.429 Hz 14537.218 Hz
14563.821 Hz 14835.809 Hz 14947.184 Hz 14948.323 Hz 15429.139 Hz
15443.309 Hz 15450.183 Hz 16026.221 Hz 16062.401 Hz 16081.291 Hz
16144.343 Hz 16331.323 Hz 17316.328 Hz 17930.967 Hz 17932.432 Hz
17951.395 Hz 17970.122 Hz 18242.181 Hz 18254.323 Hz 18265.238 Hz
18337.222 Hz 18344.212 Hz 18378.321 Hz 18921.415 Hz 18926.951 Hz
18931.327 Hz 19124.197 Hz 19133.123 Hz 19321.231 Hz 19686.593 Hz
114508.332 Hz
[00158] Treatment of kidney cancer
[00159] Kidney cancer may be treated according to the methods disclosed herein by the application of kidney cancer spécifie amplitude-modulated frequencies. Kidney cancer spécifie 5 frequencies are provided below in Table 25. A patient suffering from kidney cancer may be treated with any number of the frequencies provided in Table 25, however it îs generally préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more of the listed kidney cancer spécifie frequencies may be used în the treatment of kidney cancer. It should be noted that 10 while the table below provides certain frequencies for treatment of kidney cancer, the disclosure is not so limiting, and other frequencies dîscovered to be effective in the treatment of kidney cancer are within the scope of this disclosure.
[00160] Table 25: Amplitude-modulated frequencies for treatment of kidney cancer.
628.321 Hz 631.141 Hz 643.312 Hz 812.512 Hz 826.321 Hz
1240.336 Hz 1372.934 Hz 2082.241 Hz 2156.931 Hz 2254.329 Hz
2286.5 Hz 3555.209 Hz 3928.343 Hz 4329.152 Hz 4420.932 Hz
4819.228 Hz 4828.321 Hz 5314.322 Hz 6007.332 Hz 7054.279 Hz
7074.429 Hz 7254.343 Hz 8041.289 Hz 8727.224 Hz 8760.983 Hz__
8831.132 Hz 8870.228 Hz 8923.1 Hz 10565.321 Hz 10586.229 Hz
11561.221 Hz 11846.212 Hz 12631.331 Hz 12693,272 Hz 14411.321 Hz
20178.941 Hz
[00161] Treatment of bladder cancer
[00162] Bladder cancer may be treated according to the methods disclosed herein by the application of bladder cancer spécifie amplitude-modulated frequencies. Bladder cancer spécifie frequencies are provided below in Table 26. A patient suffering from bladder cancer may be treated with any number of the frequencies provided în Table 26, however it is generally préférable 20 to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly,
or more, 15 or more, or 20 or more, 25 or more, or 30 or more of the listed bladder cancer spécifie frequencies may be used in the treatment of bladder cancer. Il should be noted that while lhe table below provides certain frequencies for treatment of bladder cancer, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of bladder cancer are 5 within the scope of this disclosure.
[00163] Table 26: Amplitude-modulated frequencies for treatment of bladder cancer.
623.243 Hz 757.084 Hz 870.4 Hz 2454.423 Hz 2480.191 Hz
2581.101 Hz 2715.232 Hz 3042.012 Hz 3196.194 Hz 3265.323 Hz
3438.109 Hz 3692.319 Hz 3952.308 Hz 5230.227 Hz 6022.942 Hz
6061.711 Hz 6710.899 Hz 6721.912 Hz 7181.784 Hz 7212.826 Hz
7458.209 Hz 8235.21 Hz 8749.232 Hz 8767.189 Hz 9354.812 Hz
9611.339 Hz 12532.729 Hz 13467.209 Hz 13777.9 Hz 14015.241 Hz
18524.419 Hz
[00164] Treatment of lung cancer
[00165] Lung cancer may be treated according to the methods disclosed herein by the application of lung cancer spécifie amplitude-modulated frequencies. Lung cancer spécifie frequencies are provided below in Table 27. A patient suffering from lung cancer may be treated with any number of the frequencies provided în Table 27, however it is generally préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or 15 more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more of the listed lung cancer spécifie frequencies may be used in the treatment of lung cancer. It should be noted that while the table below provides certain frequencies for treatment of lung cancer, the disclosure îs not so limiting, and other frequencies discovered to be effective in the treatment of lung cancer are within the scope of this disclosure.
[00166] Table 27: Amplitude-modulated frequencies for treatment of lung cancer.
304.148 Hz 694.7 Hz 694.727 Hz 708.8 Hz 708.841 Hz
1587.811 Hz 1759.318 Hz 1873.477 Hz 2253.704 Hz 2391.312 Hz
2454.232 Hz 2729.929 Hz 2741.261 Hz 2761.312 Hz 2784.491 Hz
2812.443 Hz 2855.218 Hz 2859.495 Hz 3128.822 Hz 3139.297 Hz
3193.212 Hz 3348.783 Hz 3360.971 Hz 3366.311 Hz 3373.892 Hz
3440.212 Hz 3461.322 Hz 3682.489 Hz 3727.231 Hz 3749.882 Hz
3769.942 Hz 4131.235 Hz 4158.393 Hz 4243.393 Hz 4347.733 Hz
4373.411 Hz 4378.321 Hz 4416.221 Hz 4481.242 Hz 4777.521 Hz
4798.422 Hz 4837.241 Hz 4959.842 Hz 5013.321 Hz 5047.523 Hz
5068.322 Hz 5371.922 Hz 5538.432 Hz 5548.879 Hz 5679.309 Hz
5734.143 Hz 5787.342 Hz 6445.309 Hz 6838.434 Hz 6870.955 Hz
6879.216 Hz 7079.411 Hz 7216.288 Hz 7376.089 Hz 7761.289 Hz
8082.173 Hz 8281.259 Hz 8352.189 Hz 8442.473 Hz 8773.916 Hz
8935.752 Hz 9121.223 Hz 9181.434 Hz 9317.913 Hz 9363.896 Hz
9736.919 Hz 9753.321 Hz 10424.908 Hz 10452.913 Hz 10824.609 Hz
11656.329 Hz 12748.919 Hz 15774.291 Hz 15798.333 Hz 16510.333 Hz
[00167] Treatment of leiomyosarcoma
[00168] Leiomyosarcoma may be treated according to the methods disclosed herein by the application of leiomyosarcoma spécifie amplitude-modulated frequencies. Leiomyosarcoma spécifie frequencies are provided below in Table 28. A patient suffering from leiomyosarcoma may be treated with any number of the frequencies provided in Table 28, however it is generally préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more of the listed leiomyosarcoma spécifie frequencies may be used in the treatment of leiomyosarcoma. It should be noted that while the table below provides certain frequencies for treatment of leiomyosarcoma, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of leiomyosarcoma are within the scope of this disclosure.
[00169] Table 28: Amplitude-modulated frequencies for treatment of leiomyosarcoma.
836.923 Hz 843.181 Hz 1411.241 Hz 2073.721 Hz 2381.443 Hz
2711.019 Hz 2911.329 Hz 3232.185 Hz 3518.321 Hz 3544.209 Hz
3569.219 Hz 4233.822 Hz 4241.321 Hz 4266.591 Hz 4337.322 Hz
4424.112 Hz 4436.111 Hz 4485.22 Hz 5545.521 Hz 5577.841 Hz
5631.422 Hz 5696.184 Hz 6472.098 Hz 6558.342 Hz 6651.276 Hz
7168.892 Hz 7406.309 Hz 7452.528 Hz 7649.209 Hz 7808.352 Hz
9040.313 Hz 9074.294 Hz 9189.092 Hz 9484.512 Hz 9943.972 Hz
12086.394 Hz
[00170] Treatment of leukemia and chronic lymphoid cancer
[00171] Leukemia and chronic lymphoid cancer may be treated according to the methods disclosed herein by the application of leukemia and chronic lymphoid cancer spécifie amplitudemodulated frequencies. Leukemia and chronic lymphoid cancer spécifie frequencies are provided below in Table 29. A patient suffering from leukemia and chronic lymphoid cancer may be treated 20 with any number of the frequencies provided in Table 29, however it is generally préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10
or more, 15 or more of the listed leukemia and chronic lymphoid cancer spécifie frequencies may be used in the treatment of leukemia and chronic lymphoid cancer. It should be noted that while the table below provides certain frequencies for treatment of leukemia and chronic lymphoid cancer, the disclosure is not so limiting, and other frequencies discovered to be effective în the treatment of leukemia and chronic lymphoid cancer are within the scope of this disclosure.
[00172] Table 29; Amplitude-modulated frequencies for treatment of leukemia and chronic lymphoid cancer.
814.413 Hz 825.145 Hz 2415,243 Hz 2436.316 Hz 2874.432 Hz
2891.029 Hz 3361.671 Hz 5245,452 Hz 5557.333 Hz 6850.197 Hz
6919.322 Hz 7587.224 Hz 7629.318 Hz 8172.405 Hz 8272.338 Hz
8438.453 Hz 12950.331Hz
[00173] Treatment of myeloma
[00174] Myeloma may be treated according to the methods dîsclosed herein by the application of myeloma spécifie amplitude-modulated frequencies. Myeloma spécifie frequencies are provided below in Table 30. A patient suffering from myeloma may be treated with any number of the frequencies provided in Table 30, however it is generally préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more, 15 or 20 or more of the listed myeloma spécifie frequencies may be used in the treatment of myeloma.
It should be noted that while the table below provides certain frequencies for treatment of myeloma, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of myeloma are within the scope of this disclosure.
[00175] Table 30: Amplitude-modulated frequencies for treatment of myeloma.
765.196 Hz 2336.238 Hz 2372.122 Hz 2381.443 Hz 2425.394 Hz
656.339 Hz 2741.261 Hz 2883.618 Hz 2919.273 Hz 3265.323 Hz
3564.455 Hz 3580.25 Hz 3584.291 Hz 3674.292 Hz 5249.331 Hz
7967.311 Hz 7973.125 Hz 8049.952 Hz 8283.329 Hz 10351.323 Hz
[00176] Treatment of lymphoma
[00177] Lymphoma may be treated according to the methods dîsclosed herein by the application of lymphoma spécifie amplitude-modulated frequencies. Lymphoma spécifie frequencies are provided below in Table 31. A patient suffering from lymphoma may be treated with any number of the frequencies provided in Table 31, however it is generally préférable to employ as many of the frequencies as is practical for the treatment of the patient. Accordingly, 10 or more, 15 or more of the listed lymphoma spécifie frequencies may be used in the treatment of lymphoma. It should be noted that while the table below provides certain frequencies for treatment of lymphoma, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of lymphoma are within the scope of this disclosure.
[00178] Table 31: Amplitude-modulated frequencies for treatment of lymphoma.
752.5 Hz 976.3 Hz 1558.223 Hz 2310.912 Hz 2477.919 Hz
2560.843 Hz 3348.783 Hz 3371.216 Hz 3605.432 Hz 3623.198 Hz
3838.281 Hz 3838.48 Hz 5102 Hz 5696.932 Hz 5724.231 Hz
6358.194 Hz 7472.211 Hz 8062.121 Hz 8222.222 Hz
[00179] Treatment of brain cancer
[00180] Brain cancer may be treated according to the methods disclosed herein by the application of brain cancer spécifie amplitude-modulated frequencies. Brain cancer spécifie frequencies are 10 provided below in Table 32. A patient suffering from brain cancer may be treated with any number of the frequencies provided in Table 32, however it is generally préférable lo employ as many of the frequencies as is practical for the treatment of the patient. Accord ingly, 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more of the listed brain cancer spécifie frequencies may be used in the treatment of brain cancer. 15 It should be noted that while the table below provides certain frequencies for treatment of brain cancer, the disclosure is not so limiting, and other frequencies discovered to be effective in the treatment of brain cancer are within the scope of this disclosure.
[00181] Table 32; Amplitude-modulated frequencies for treatment of brain cancer.
1372.934 Hz 2318.182 Hz 2381.443 Hz 2425.394 Hz 2442.423 Hz
2478.973 Hz 2654.513 Hz 2661.324 Hz 2686.105 Hz 2690.179 Hz
3249.332 Hz 3277.509 Hz 3335.279 Hz 3348.783 Hz 3436.211 Hz
3916.321 Hz 4031.933 Hz 4086.091 Hz 4241.321 Hz 4318.222 Hz
4334.33 Hz 4358.333 Hz 4393.419 Hz 4454.194 Hz 4515.789 Hz
4619.324 Hz 4723.937 Hz 4853.286 Hz 5289.231 Hz 5378.099 Hz
5426.323 Hz 5640.981 Hz 6316.211 Hz 6459.203 Hz. 6474.332 Hz
6626.572 Hz 6855.286 Hz 6915.886 Hz 6943.386 Hz 7151.264 Hz
7182.922 Hz 7194.897 Hz 7323.209 Hz 7390.343 Hz 7796.221 Hz
7961.122 Hz 8128.942 Hz 8245.109 Hz 8272.281 Hz 8358.154 Hz
8408.121 Hz 9138.82 Hz 10719.318 Hz 11556.241 Hz 12828.633 Hz
14515.962 Hz 14586.765 Hz.
[00182] The following are synopses relate to exemplary uses of the electronic devices of the présent invention and the cancer spécifie frequencies for the treatment of patients:
Example A
[00183] A 79-year-old man was diagnosed with hepatitis A and B négative hepatocellular carcinoma. He underwent left hepatectomy the following month, which revealed the presence of a poorly differentiated hepatocellular carcinoma. The tumors largest diameter was 10 cm and was staged as pT3NxMx. After five months from diagnosis, the patient had evidence of dîsease progression with four new lésions identified within the right lobe of the liver and new médiastinal 10 adenopathy, and chemoembolization with doxorubicin and lipiodol was performed over the next month. A follow up MRI performed the following month showed progression of dîsease. Treatment with sorafenib was initiated when the patient’s performance status was KPS 80%, ECOG 1 with a Child Pugh of A6. Simultaneous compassionate treatment with the TheraBionic device emitting 206 hepatocellular carcinoma (HCC) spécifie frequencies was administered 3 hours a day. The patient had a complété response by marker as the level of alpha-fetoprotein (AFP) decreased from 92,620-0 international units/ml (lU/ml) prior to treatment initiation to 4.18 lU/ml, measured a year from the original diagnosis and 4 months after commencing treatment with the HCC spécifie frequencies.
[00184] Nexavar was discontînued in the beginning of the third year following the initial diagnosis because of intolérable si de effects. One month after discontinuation of Nexavar, there was evidence of early dîsease progression with a doubling of the AFP level, and near doubling of the levels of liver enzymes ASAP, ALAT, and gamma GT. The patient was re-examined for tumorspecific frequencies using the method described above. The analysis revealed puise pressure changes for additional HCC spécifie frequencies. Fifty HCC frequencies were added to the 206
HCC frequencies, i.e., the patient began receiving 256 frequencies with each treatment. A new MRI of the abdomen obtained in seven months later revealed the émergence of new tumor nodules. The patient was re-examined on the following month using the method described above. The analysis revealed puise pressure changes for 12 additional HCC spécifie frequencies, bringing the total number to 268 HCC spécifie frequencies. The same approach was used whenever there was 30 either clear progression by changes in AFP levels and/or significant enlargement of existing tumor masses and/or emergence of new tumor masses. Addition of new HCC spécifie frequencies led to significant decrease or stabilization of tumor masses as well as decreases in AFP levels. In the last year of treatment, the patient received a total of 422 HCC spécifie frequencies.
[00185] The patient received treatment with the TheraBionic device for 67 months, when he became unable to receive treatment on a régulai basis because of a hip fracture secondary to a fall, generaiized weakness, and worsening rénal failure. He passed away in six months later. In summary, addition of HCC spécifie frequencies led to repeated objective clinical responses assessed both radiologically and by tumor marker, which led to an exceptionally long survival (more than 6 years) in a patient with rapidly progressive advanced hepatocellular carcinoma.
[00186] Example B
[00187] 87-year-old man with a long-standing history of type II diabètes was diagnosed with advanced unresectable multifocal hepatocellular carcinoma. He declîned treatment with Nexavar and requested compassionate use treatment with the TheraBionic device. He began receiving treatment with 313 HCC spécifie frequencies two months after diagnosîs. The patient had stable disease for 13 months when he had evidence of disease progression by RECIST criteria. He began receiving treatment with 355 HCC spécifie frequencies within the following month. A follow-up MRI of the abdomen obtained after two months revealed the presence of necrosis within 2 lésions and stable disease in the others. Hence, the addition of 42 HCC spécifie frequencies led to a radiological response. A follow-up MRI of the abdomen obtained two months later showed stable disease by RECIST criteria. A follow-up MRI of the liver obtained after three months showed progression of disease by RECIST criteria with the appearance of new liver lésions. Two weeks later, the patient was examined with the method described above and changes in puise pressure were observed for 49 additional HCC frequencies. Hence, the patient began receiving treatment with 404 frequencies as of that month. A repeat MRI of the abdomen obtained three months later showed stable disease. The patient continued to do well over the next two months when he had gastrointestinal bleeding due to esophageal varices. He declined treatment for esophageal varices and passed away later that month. Hence, treatment of this patient demonstrates the clinical efficacy of additional HCC frequencies, which led to both objective response and stable disease.
[00188] Background
[00189] A portable and programmable device as described herein that is capable of delivering low levels of amplitude-modulated electromagnetic fields has been developed. The device emits a 27 MHz radiofrequency signal, amplitude-modulated at cancer-specific frequencies ranging from
0.1 to 150 kHz with high précision. The device is connected to a spoon-like coupler, which is placed in the patient’s mouth during treatment.
Example 1: Treatment of Breast Cancer
[00190] Breast cancer may be treated according to the methods dîsclosed herein by the application 10 of breast cancer spécifie amplitude-modulated frequencies. Breast cancer spécifie frequencies are provided below in Table 33.
[00191] Table 33: Amplitude-modulated frequencies discovered lo be effective for treatment of breast cancer.
374-374.7 Hz 419.8-420.4 Hz 420.4-420.8 Hz 429-429.7 Hz 1336-1336.7 Hz
1369-1369.7 Hz 1728-1728.7 Hz 1771.8-1772.3 Hz 1772.3-1772.8 Hz 2811-2811.7 Hz
2824-2S24.7 Hz 2840-2840.7 Hz 2858.8-2859.35Hz 2860-2860.7 Hz 2878-2878.7 Hz
2890-2890.7 Hz 3209-3209.7 Hz 3322-3322.7 Hz 3360-3360.7 Hz 3663-3663.7 Hz
3839-3839.7 Hz 3842.4-3843 Hz 3854-3854.7 Hz 3936-3936.7 Hz 4323-4323.7 Hz
4329-4329.7 Hz 4416-4416.7 Hz 4430-4430.7 Hz 4477.4-4478 Hz 4480.9-4481.35Hz
4714-4714.7 Hz 4805.3-4806 Hz 4813-4813.7 Hz 4819-4819.7 Hz 4822-4822.7 Hz
4823-4823.7 Hz 4833-4833.7 Hz 4890-4890.7 Hz 5154-5154.7 Hz 5243-5243.7 Hz
5407.3-5408 Hz 5716-5716.7 Hz 5976-5976.7 Hz 6024-6024.7 Hz 6070-6070.7 Hz
6094-6094.7 Hz 6414-6414.7 Hz 6717-6717.7 Hz 6751-6751.7 Hz 6968.4-6969 Hz
7013-7013.7 Hz 7042-7042.7 Hz 7080-7080.7 Hz 7145.4-7146 Hz 7151-7151.7 Hz _
7158-7158.7 Hz 7225-7225.7 Hz 8332-8332.7 Hz 8824-8824.7 Hz 8837-8837.7 Hz
9935-9935.7 Hz 9961-9961.7 Hz 10013-10013.7 Hz 10064-10064.7 Hz 10339.8-10340.4 Hz
10384-10384.7 Hz 10745-10745.7 Hz 10788-10788.7 Hz 10834-10834.7 Hz 10854-10854.7 Hz
10873-10873.7 Hz 10894-10894.7 Hz 11163-11163.7 Hz 11414-11414.7 Hz 11421-11421.7 Hz
11429-11429.7 Hz 11719-11719.7 Hz 11745-11745.7 Hz 11931-11931.7 Hz 11974-11974.7 Hz
11993-11993.7 Hz 12118-12118.7 Hz 12137-12137.7 Hz 12144-12144.7 Hz 12318-12318.7 Hz
12342-12342.7 Hz 12364-12364.7 Hz 12557-12557.7 Hz 12588-12588.7 Hz 13329-13329.7 Hz
13377-13377.7 Hz 13386-13386.7 Hz 13644-13644.7 Hz 13661-13661.7 Hz 13713-13713.7 Hz
14164-14164.7 Hz 14308-14308.7 Hz 14333.4-14333.9 Hz 14432-14432.7 Hz 14524-14524.7 Hz
14589-14589.7 Hz 14729-14729.7 Hz 14813-14813.7 Hz 14835-14835.7 Hz 14858-14858.7 Hz
14885-14885.7 Hz 15035-15035.6 Hz 15067-15067.7 Hz 15126-15126.7 Hz 15195-15195.7 Hz
15269-15269.7 Hz 15432-15432.7 Hz 15432-15432.7 Hz 15563-15563.7 Hz 15621-15621.7 Hz
15624-15624.7 Hz 15642-15642.7 Hz 15647-15647.7 Hz 15669-15669.7 Hz 15698-15698.7 Hz
15823-15823.7 Hz 16347-16347.7 Hz 17832-17832.7 Hz 18221-18221.7 Hz 18260-18260.7 Hz
19433-19433.7 Hz 19446-19446.7 Hz 19489.3-19490 Hz 19782-19782.7 Hz 19827-19827.7 Hz
21291.4-21292 Hz 21887-21887.7 Hz 22020-22020.7 Hz 22419-22419.7 Hz 22422-22422.7 Hz
22425-22425.7 Hz 22444-22444.7 Hz 22491-22491.7 Hz 22840.3-22841 Hz 22859-22859.7 Hz
22973-22973.7 Hz 22983-22983.7 Hz 23258-23258.7 Hz 23652-23652.7 Hz 24174-24174.7 Hz
24811-24811.7 Hz 26954-26954.7 Hz 27114-27114.7 Hz 30463.3-30464 Hz 34557.3-34558 Hz
34854-34854.7 Hz 38144-38144.7 Hz 38682-38682.7 Hz 41561-41561.7 Hz 41623-41623.7 Hz
41735-41735.7 Hz 42713-42713.7 Hz 44575.3-44576 Hz 46662-46662.7 Hz 48173-48173.7 Hz
50292-50292.7 Hz
Example 2: Treatment of neuroendocrine tumors
[00192] Neuroendocrine tumors may be treated according to the methods disclosed herein by the application of neuroendocrine tumor spécifie amplitude-modulated frequencies. Neuroendocrine tumors spécifie frequencies are provided below in Table 34.
[00193] Table 34: Amplitude-modulated frequencies discovered to be effective for treatment of neuroendocrine tumors.
843-843.7 Hz 1656-1656.7 Hz 2423-2423.7 Hz 2480-2480.7 Hz 2707-2707.7 Hz
2890-2890.7 Hz 3080.3-3081 Hz 3661-3661.7 Hz 3678-3678.7 Hz 3976.4-3977 Hz
4048-4048,7 Hz 4055-4055.7 Hz 4368.3-4369 Hz 4459-4459.7 Hz 4621-4621.7 Hz
4837-4837.7 Hz 4866-4866.7 Hz 5165.4-5166 Hz 5265-5265.7 Hz 5270-5270.7 Hz
6436-6436.7 Hz 7037-7037.7 Hz 8008-8008.7 Hz 8024-8024.7 Hz 8097-8097.7 Hz
8427-8427.7 Hz 8478.3-8479 Hz 8480-8480.7 Hz 8492-8492.7 Hz 8853-8853.7 Hz
8877-8877.7 Hz 9122-9122.7 Hz 9131-9131.7 Hz 9174-9174.7 Hz 10073-10073.7 Hz
10848.7-10849.3 Hz 11267-11267.7 Hz 11336-11336.7 Hz 11524-11524.7 Hz 11551.3-11552 Hz
11927.4-11928 Hz 12309-12309.7 Hz 13617-13617.7 Hz 13674-13674.7 Hz 13774-13774.7 Hz
14350-14350.7 Hz 14456-14456.7 Hz 14479-14479.7 Hz 14540-14540.7 Hz 14553-14553.7 Hz
14756-14756.7 Hz 14922-14922.7 Hz 14961-14961.7 Hz 15226-15226.7 Hz 15817-15817.7 Hz
15825-15825.7 Hz 15835-15835.7 Hz 15836-15836.7 Hz 15897-15897.7 Hz 16071-16071.7 Hz
17417-17417,7 Hz 17418-17418.7 Hz 17473-17473.7 Hz 17474-17474.7 Hz 17621-17621.7 Hz
17655-17655.7 Hz 18655-18655.7 Hz 18672-18672.7 Hz 18678-18678.7 Hz 19393-19393.7 Hz
19426-19426.7 Hz 19817-19817.7 Hz 19819-19819.7 Hz 19861-19861.7 Hz 19867-19867.7 Hz
20818-20818.7 Hz 21708-21708.7 Hz 21720-21720.7 Hz 21865-21865.7 Hz 21876-21876.7 Hz
22119-22119.7 Hz 22454-22454.7 Hz 24073-24073.7 Hz 30304-30304.7 Hz 31685-31685.7 Hz
43633-43633.7 Hz 44773-44773.7 Hz 46662-46662.7 Hz 46793-46793.7 Hz 48103-48103.7 Hz
50243-50243.7 Hz
Example 3: Treatment of non-Hodgkin lymphoma
[00194] Non-Hodgkin lymphoma tumors may be treated according to the methods disclosed herein by the application of non-Hodgkin lymphoma spécifie amplitude-modulated frequencies. Non-Hodgkin lymphoma tumors spécifie frequencies are provided below in Table 35.
[Ü0195] Table 35: Amplitude-modulated frequencies discovered to be effective for treatment of non-Hodgkin lymphoma.
3222-3222.7 Hz 3228-3228.7 Hz 3272-3272.7 Hz 3618-3618.7 Hz 4523-4523.7 Hz
4556-4556.7 Hz 4584-4584.7 Hz 5116-5116.7 Hz 5142-5142.7 Hz 6413-6413.7 Hz
6419.3-6420 Hz 6441-6441.7 Hz 6474-6474.7 Hz 6911.3-6912 Hz 6912-6912.7 Hz
6943-6943.7 Hz 7551-7551.7 Hz 7811-7811.7 Hz 7857-7857.7 Hz 7865-7865.7 Hz
8125-8125.7 Hz 9106-9106.7 Hz 9161-9161.7 Hz 9179-9179.7 Hz 9230-9230.7 Hz
9236-9236.7 Hz 9247-9247.7 Hz 11730.6-11731.1 Hz 11785-11785.7 Hz 13222-13222.7 Hz
13751-13751.7 Hz 13780-13780.7 Hz 15006-15006.7 Hz 15033-15033.7 Hz 15056-15056.7 Hz
15729-15729.7 Hz 15773-15773.7 Hz 17229-17229.7 Hz 17246-17246.7 Hz 17268-17268.7 Hz
20256-20256.7 Hz 22444-22444.7 Hz 30666-30666.7 Hz 30713-30713.7 Hz 30843-30843.7 Hz
38216-38216.7 Hz
Example 4: Treatment of adenocarcinoma of pancréas
[00196] Adenocarcinoma of pancréas may be treated according to the methods disclosed herein by the application of adenocarcinoma of pancréas spécifie amplitude-modulated frequencies. Adenocarcinoma of pancréas spécifie frequencies are provided below in Table 36.
[00197] Table 36: Amplitude-modulated frequencies discovered to be effective for treatment of adenocarcinoma of the pancréas.
403-403.7 Hz 441-441.7 Hz 527-527.7 Hz 624.32-624.8 Hz 633-633.7 Hz
727-727.7 Hz 759-759.7 Hz 785-785.7 Hz 811-811.7 Hz 829-829.7 Hz
841-841.7 Hz 962-962.7 Hz 964.5-965 Hz 972-972.7 Hz 974.4-975 Hz
977-977.7 Hz 1179.2-1179.8 Hz 1250.3-1251 Hz 1314-1314.7 Hz 1352-1352.7 Hz
1622-1622.7 Hz 1652-1652.7 Hz 1656-1656.7 Hz 1670.3-1671 Hz 1914-1914.7 Hz
2346-2346.7 Hz 2362-2362.7 Hz 2380-2380.7 Hz 2469.2-2469.7 Hz 2627-2627.7 Hz
2706-2706.7 Hz 2720.3-2721 Hz 2726-2726.7 Hz 2754-2754.7 Hz 2778-2778.7 Hz
2842-2842.7 Hz 2864-2864.7 Hz 2940-2940.7 Hz 2988-2988.7 Hz 3234-3234.7 Hz
3280.6-3281.3 Hz 3366-3366.7 Hz 3428-3428.7 Hz 3446-3446.7 Hz 3466-3466.7 Hz
3523-3523.7 Hz 3605-3605.7 Hz 3622,5-3623 Hz 3627-3627.7 Hz 3631-3631.7 Hz
3656-3656.7 Hz 3663-3663.7 Hz 3667-3667.7 Hz 3687-3687.7 Hz 4152-4152.7 Hz
4233-4233.7 Hz 4249-4249.7 Hz 4281-4281.7 Hz 4368.3-4369 Hz 4417-4417.7 Hz
4425-4425.7 Hz 4440.4-4441 Hz 4465-4465.7 Hz 4480.9-4481.35 Hz 4580.11-4580.7 Hz
4621-4621.7 Hz 4637-4637.7 Hz 4657-4657.6 Hz 4725-4725.7 Hz 4733-4733.7 Hz
4749-4749.7 Hz 4841-4841.7 Hz 4924-4924.7 Hz 4946-4946.7 Hz 5063-5063.7 Hz
5089-5089.7 Hz 5378.2-5378.7 Hz 5424-5424.7 Hz 5438-5438.7 Hz 6112-6112.7 Hz
6159-6159.7 Hz 6161.3-6162 Hz 6167-6167.7 Hz 6179-6179.7 Hz 6220.3-6221 Hz
6346-6346.7 Hz 6380.4-6381 Hz 6808-6808.7 Hz 6825-6825.7 Hz 6847-6847.7 Hz
6850-6850.7 Hz 6878-6878.7 Hz 7036-7036.7 Hz 7037-7037.7 Hz 7118-7118.7 Hz
7160-7160.7 Hz 7432-7432.7 Hz 7541-7541.7 Hz 7676-7676.7 Hz 7936-7936.7 Hz
8024-8024.7 Hz 8032-8032.7 Hz 8043-8043.7 Hz 8447-8447.7 Hz 8734-8734.7 Hz
8756-8756.7 Hz 8757-8757.7 Hz 8809-8809.7 Hz 8823-8823.7 Hz 8841-8841.7 Hz
8845-8845.7 Hz 8846-8846.7 Hz 8872-8872.7 Hz 9133-9133.7 Hz 9155.7-9156.2 Hz
9520-9520.7 Hz 9859-9859.7 Hz 10342-10342.6 Hz 10352-10352.7 Hz 10378-10378.7 Hz
10436-10436.7 Hz 10566.4-10567 Hz 10633-10633.7 Hz 10641-10641.7 Hz 10671-10671.7 Hz
10708-10708.7 Hz 10859-10859.7 Hz 10876-10876.7 Hz 11174-11174.7 Hz 11220-11220.7 Hz
11247-11247.7 Hz 11264-11264.7 Hz 11284-11284.7 Hz 11630-11630.7 Hz 11994-11994.7 Hz
12120.2-12120.7 Hz 12135-12135.7 Hz 12152-12152.7 Hz 12184-12184.7 Hz 12711-12711.7 Hz
13375-13375.7 Hz 13571-13571.7 Hz 13636.2-13636.7 Hz 13738.3-13739 Hz 13947-13947.7 Hz
14116-14116.7 Hz 14279-14279.7 Hz 14376-14376.7 Hz 14462-14462.7 Hz 14519-14519.7 Hz
14558-14558.7 Hz 14729-14729.7 Hz 14940.4-14941 Hz 14957-14957.7 Hz 15179-15179.7 Hz
15225-15225.6 Hz 15536-15536.7 Hz 15576-15576.7 Hz 15597-15597.7 Hz 15663-15663.7 Hz
15678-15678.7 Hz 15711-15711.7 Hz 15724-15724.7 Hz 15740-15740.7 Hz 15749-15749.7 Hz
15824-15824.7 Hz 15867-15867.7 Hz 16143-16143.7 Hz 17214-17214.7 Hz 17253-17253.7 Hz
17271-17271.7 Hz 17283-17283.7 Hz 17739-17739.7 Hz 17944-17944.7 Hz 17962-17962.7 Hz
18279-18279.7 Hz 18678.7-18679.3 Hz 18921-18921.7 Hz 18922-18922.7 Hz 19059-19059.7 Hz
19464-19464.7 Hz 19686-19686.4 Hz 19724-19724.7 Hz 20123-20123.7 Hz 20128-20128.7 Hz
20144-20144.7 Hz 20149.3-20150 Hz 20219-20219.7 Hz 20254-20254.7 Hz 21546-21546.7 Hz
21616-21616.7 Hz 21664-21664.7 Hz 21840-21840.7 Hz 21876-21876.7 Hz 21894-21894.7 Hz
22355-22355.7 Hz 22430-22430.7 Hz 22597-22597.7 Hz 22742-22742.7 Hz 22822-22822.7 Hz
22846-22846.7 Hz 22867-22867.7 Hz 23237-23237.7 Hz 23284-23284.7 Hz 24228-24228.7 Hz
24275-24275.7 Hz 24508-24508.7 Hz 24609.3-24610 Hz 24841-24841.7 Hz 27478-27478.7 Hz
32143-32143.7 Hz 32493-32493.7 Hz 33546-33546.7 Hz 40133-40133.7 Hz 40595-40595.7 Hz
44913-44913.7 Hz 45474-45474.7 Hz 46672.3-46673 Hz 48204-48204.7 Hz 48314-48314.7 Hz
50072-50072.7 Hz 50254-50254.7 Hz 52812-52812.7 Hz 79867-79867.7 Hz 80993.3-80994 Hz
91877-91877.7 Hz 95742-95742.7 Hz.
Example 5: Treatment of head and neck cancer
[00198] Head and neck cancer may be treated according to the methods disclosed herein by the application of head and neck cancer spécifie amplitude-modulated frequencies. Head and neck cancer spécifie frequencies are provided below in Table 37.
[00199] Table 37: Amplitude-modulated frequencies discovered to be effective for treatment of head and neck cancer.
1858-1858.7 Hz 2893-2893.7 Hz 5152-5152.7 Hz 6897-6897.7 Hz 7080-7080.7 Hz
7136-7136.7 Hz 7274-7274.7 Hz 8755-8755.7 Hz 9573-9573.7 Hz 9656-9656.7 Hz
10439-10439.7 Hz 10484-10484.7 Hz 10645-10645.7 Hz 10673-10673.7 Hz 11559-11559.7 Hz
14052-14052.7 Hz 17379-17379.7 Hz 19269-19269.7 Hz
Example 6: Treatment of gastric cancer
[00200] Gastric cancer may be treated according to the methods disclosed herein by the application of gastric cancer spécifie amplitude-modulated frequencies. Gastric cancer spécifie frequencies are provided below in Table 38.
[00201] Table 38: Amplitude-modulated frequencies discovered to be effective for treatment of gastric cancer.
374-374.7 Hz 560-560.7 Hz 628-628.7 Hz 642.4-643 Hz 708.3-709 Hz
749-749.7 Hz 806-806.6 Hz 825-825.7 Hz 843-843.7 Hz 914-914.7 Hz
959-959.7 Hz 969-969.7 Hz 1157-1157.7 Hz 1436-1436.7 Hz 1656-1656.7 Hz
2379.3-2380 Hz 2417-2417.7 Hz 2436-2436.7 Hz 2455-2455.7 Hz 2478-2478.7 Hz
2747-2747.7 Hz 2762-2762.7 Hz 2774-2774.7 Hz 2856.4-2857 Hz 2891-2891.7 Hz
2981-2981.7 Hz 3104.3-3105 Hz 3133-3133.7 Hz 3522-3522.7 Hz 3537-3537.7 Hz
3549-3549.7 Hz 3556-3556.7 Hz 3595-3595.7 Hz 3927-3927.7 Hz 4154-4154.7 Hz
4548-4548.7 Hz 4723-4723.7 Hz 5286-5286.7 Hz 5494.4-5495 Hz 5548.3-5549 Hz
5742-5742.7 Hz 6010-6010.7 Hz 6064-6064.7 Hz 6329-6329.7 Hz 6444-6444.7 Hz
6469-6469.7 Hz 6488-6488.7 Hz 7222.4-7223 Hz 7646-7646.7 Hz 7748-7748.7 Hz
7855-7855.7 Hz 7927-7927.7 Hz. 7951-7951.7 Hz 7970-7970.7 Hz 7979-7979.7 Hz
8039-8039.7 Hz 8055.4-8056 Hz 8926-8926.7 Hz 9109-9109.7 Hz 9123-9123.7 Hz
9136-9136.7 Hz 9146-9146.7 Hz 9157-9157.7 Hz 9194-9194.7 Hz 10137-10137.7 Hz
10345-10345.7 Hz 10727-10727.7 Hz 10802-10802.7 Hz 11533-11533.7 Hz 12165-12165.7 Hz
13241-13241.7 Hz 13307-13307.7 Hz 13330.7-13331.2 Hz 13408-13408.7 Hz 13434-13434.7 Hz
13714-13714.7 Hz 13746-13746.7 Hz 14016.4-14017 Hz 14160-14160.7 Hz 14483-14483.7 Hz
14511-14511.7 Hz 14670.4-14671 Hz 16309-16309.7 Hz 17418-17418.7 Hz 17455-17455.7 Hz
17485-17485.7 Hz 17581-17581.7 Hz 19125-19125.7 Hz 21430-21430.7 Hz 21714-21714.7 Hz
23946-23946.7 Hz 39586-39586.7 Hz 40734-40734.7 Hz 41172-41172.7 Hz 42146-42146.7 Hz
46143-46143.7 Hz
Example 7: Treatment of glioblastoma
[00202] Glioblastoma may be treated according to the methods disclosed herein by the application of glioblastoma spécifie amplitude-modulated frequencies. Glioblastoma spécifie frequencies are provided below in Table 39.
[00203] Table 39: Amplitude-modulated frequencies discovered to be effective for treatment of glioblastoma.
262-262.7 Hz 295-295.6 Hz 415-415.7 Hz 418-418.7 Hz 423-423.7 Hz
434-434.7 Hz 440.4-441 Hz 476-476.7 Hz 556-556.7 Hz 608-608.7 Hz
612-612.7 Hz 627-627.7 Hz 656-656.7 Hz 694-694.7 Hz 708.3-709 Hz
741-741.7 Hz 752.4-753 Hz 757-757.6 Hz 759-759.7 Hz 776-776.7 Hz
796.3-797 Hz 836-836.7 Hz 941-941.7 Hz 1027-1027.7 Hz 1045-1045.7 Hz
1195-1195.7 Hz 1868-1868.7 Hz 1897-1897.7 Hz 2044-2044.7 Hz 2439-2439.7 Hz
2612-2612.7 Hz 2632-2632.7 Hz 2653.3-2654 Hz 2686-2686.7 Hz 2690-2690.7 Hz
2697-2697.7 Hz 2738-2738.7 Hz 3157-3157.7 Hz 3218-3218.7 Hz 3227.3-3228 Hz
3249-3249.7 Hz 3277.3-3278 Hz 3281.6-3282.1 Hz 3436-3436.7 Hz 3633-3633.7 Hz
3656-3656.7 Hz 3962-3962.7 Hz 4148-4148.7 Hz 4241-4241.7 Hz 4410-4410.7 Hz
4416-4416.7 Hz 4454-4454.7 Hz 4619-4619.7 Hz 4632-4632.7 Hz 4853-4853.7 Hz
5139-5139.7 Hz 5156-5156.7 Hz 5996-5996.7 Hz 6292-6292.7 Hz 6297-6297.7 Hz
6459-6459.7 Hz 6474-6474.7 Hz 6492.3-6493 Hz 6626.3-6627 Hz 6727.4-6728 Hz
6809-6809.6 Hz 6841-6841.7 Hz 6915.3-6916 Hz 6943-6943.7 Hz 7110-7110.7 Hz
7182.4-7183 Hz 7194.3-7195 Hz 7268-7268.7 Hz 7323-7323.7 Hz 7480-7480.7 Hz
7663-7663.7 Hz 7796-7796.7 Hz 7936-7936.7 Hz 8070-8070.7 Hz 8128.4-8129 Hz
8145-8145.7 Hz 8158-8158.7 Hz 8314-8314.7 Hz 8355-8355.7 Hz 8484-8484.7 Hz
9138.3-9139 Hz 9155.7-9156.2Hz 9921-9921.7 Hz 10427-10427.7 Hz 10468-10468.7 Hz
10478-10478.7 Hz 10719-10719.7 Hz 10802-10802.7 Hz 10809-10809.7 Hz 10851-10851.7 Hz
11556-11556.7 Hz 11913-11913.7 Hz 12828.3-12829 Hz 13686.4-13687 Hz 14249-14249.7 Hz
14515.4-14516 Hz 14586.3-14587 Hz 14796-14796.7 Hz 15067-15067.7 Hz 15112-15112.7 Hz
17095-17095.7 Hz 17167-17167.7 Hz 18090-18090.7 Hz 18670.3-18671 Hz 18895-18895.7 Hz
19026-19026.7 Hz 20237-20237.7 Hz 20254-20254.7 Hz 20286-20286.7 Hz 24196-24196.7 Hz
25199-25199.7 Hz 26073-26073.7 Hz 26163-26163.7 Hz 26164-26164.7 Hz 30759-30759.7 Hz
32591.3-32592 Hz 36343-36343.7 Hz 41883-41883.7 Hz 44517-44517.7 Hz 44531-44531.7 Hz
45490-45490.7 Hz 47297-47297.7 Hz 49434-49434.7 Hz 50229-50229.7 Hz 69481-69481.7 Hz
78477.4-78478 Hz 80993.3-80994 Hz 81999-81999.7 Hz 85810-85810.7 Hz 89748-89748.7 Hz
92182-92182.7 Hz 95245-95245.7 Hz
Example 8: Treatment of squamous cell carcinoma of the anal canal
[00204] Squamous cell carcinoma of the anal canal may be treated according to the methods disclosed herein by the application of squamous cell carcinoma of the anal canal spécifie amplitude-modulated frequencies. Squamous cell carcinoma of the anal canal spécifie frequencies are provided below în Table 40.
[00205] Table 40: Amplitude-modulated frequencies discovered to be effective for treatment of squamous cell carcinoma of the anal canal.
295-295.6 Hz 304-304.7 Hz 436-436.7 Hz 581-581.7 Hz 679-679.7 Hz
694.3-695 Hz 708.3-709 Hz 796.3-797 Hz 1759-1759.7 Hz 1858-1858.7 Hz
1873-1873.7 Hz 2442-2442.7 Hz 2522-2522.7 Hz 2648-2648.7 Hz 2893-2893.7 Hz
2975-2975.7 Hz 2981-2981.7 Hz 3238-3238.7 Hz 3249.3-3250 Hz 3250.3-3250.8 Hz
3461-3461.7 Hz 3531-3531.7 Hz 3535-3535.7 Hz 3681-3681.7 Hz 4279-4279.7 Hz
4440.4-4441 Hz 4718-4718.7 Hz 4876-4876.7 Hz 5034-5034.7 Hz 5068-5068.7 Hz
5151-5151.7 Hz 5249-5249.7 Hz 5286-5286.7 Hz 5869-5869.7 Hz 5881-5881.7 Hz
6298.4-6299 Hz 6851-6851.7 Hz 6879-6879.7 Hz 6882.4-6883 Hz 6897-6897.7 Hz
6980.3-6981 Hz 7136-7136.7 Hz 7274-7274.7 Hz 7673-7673.7 Hz 7930-7930.7 Hz
7981-7981.7 Hz 8328-8328.7 Hz 8432-8432.7 Hz 8755-8755.7 Hz 8949-8949.7 Hz
9656-9656.7 Hz 10439-10439.7 Hz 10484-10484.7 Hz 11145-11145.7 Hz 11159-11159.7 Hz
11253-11253.7 Hz 11260-11260.7 Hz 11277.3-11278 Hz 11559-11559.7 Hz 11699-11699.7 Hz
11905-11905.7 Hz 12139-12139.7 Hz 13819-13819.7 Hz 13847-13847.7 Hz 13903-13903.7 Hz
17379-17379.7 Hz 18618-18618.7 Hz 18742-18742.7 Hz 21445-21445.7 Hz 21467-21467.7 Hz
22763-22763.7 Hz 33536-33536.7 Hz 37527-37527.7 Hz 37546-37546.7 Hz 53079-53079.7 Hz
58094-58094.7 Hz 59288-59288.7 Hz 59997-59997.7 Hz 88281-88281.7 Hz
Example 9: Treatment of hepatocellular carcinoma
[00206] Hepatocellular carcinoma may be treated according to the methods disclosed herein by the application of hepatocellular carcinoma spécifie amplitude-modulated frequencies. Hepatocellular carcinoma spécifie frequencies are provided below in Table 41.
[00207] Table 41: Amplitude-modulated frequencies discovered to be effective for treatment of hepatocellular carcinoma.
439-439.7 Hz 594-594.7 Hz 737-737.7 Hz 817-817.7 Hz 966-966.7 Hz
996-996.7 Hz 1785-1785.7 Hz 1823-1823.7 Hz 1881-1881.7 Hz 1963-1963.7 Hz
1973-1973.7 Hz 2189-2189.7 Hz 2321-2321.7 Hz 2372.3-2372.8 Hz 2459-2459.7 Hz
2647-2647.7 Hz 2825-2825.7 Hz 2836-2836.7 Hz 2860-2860.7 Hz 2971-2971.6 Hz
3171-3171.7 Hz 3188-3188.7 Hz 3749-3749.7 Hz 3762-3762.7 Hz 3823-3823.7 Hz
4007-4007.7 Hz 4013-4013.7 Hz 4454-4454.7 Hz 4997-4997.7 Hz 5151-5151.7 Hz
5239-5239.7 Hz 5322-5322.7 Hz 6317-6317.7 Hz 6330-6330.7 Hz 6334-6334.7 Hz
6432-6432.7 Hz 684Ü-6840.7 Hz 7098-7098.7 Hz 7169-7169.7 Hz 7239-7239.7 Hz
7338-7338.7 Hz 7378-7378.7 Hz 7481-7481.7 Hz 7510-7510.7 Hz 7719-7719.7 Hz
7748-7748.7 Hz 7787-7787.7 Hz 8388-8388.7 Hz 8412-8412.7 Hz 9588-9588.7 Hz
8522-8522.7 Hz 8845-8845.7 Hz 8935-8935.6 Hz 8949-8949.7 Hz 9273-9273.7 Hz
9695-9695.7 Hz 10387-10387.7 Hz 10641-10641.7 Hz 10731-10731.7 Hz 10740-10740.7 Hz
10762-10762.7 Hz 10768-10768.7 Hz 10776-10776.7 Hz 10805-10805.7 Hz 10831-10831.7 Hz
10889-10889.7 Hz 11209-11209.7 Hz 11243-11243.7 Hz 11247-11247.7 Hz 11275-11275.7 Hz
11295-11295.7 Hz 11569-11569.7 Hz 11590-11590.7 Hz 11946-11946.7 Hz 12498-12498.7 Hz
12572-12572.7 Hz 12649-12649.7 Hz 13215-13215.7 Hz 13252-13252.7 Hz 13735-13735.7 Hz
13856-13856.7 Hz 14114-14114.7 Hz 14170.7-14171.3 Hz 14532-14532.7 Hz 14574-14574.7 Hz
15521-15521.7 Hz 15528-15528.7 Hz 15546.3-15547 Hz 15589-15589.7 Hz 15982-15982.7 Hz
16381-16381.7 Hz 17556-17556.7 Hz 17749-17749.7 Hz 17978-17978.7 Hz 18030-18030.7 Hz
18246-18246.7 Hz 18567-18567.7 Hz 18686-18686.7 Hz 18842-18842.7 Hz 18897-18897.7 Hz
19510-19510.7 Hz 20324-20324.7 Hz 20825-20825.7 Hz 20908-20908.7 Hz 21616-21616.7 Hz
21778-21778.7 Hz 21876-21876.7 Hz 22353-22353.7 Hz 22459-22459.7 Hz 22535-22535.7 Hz
22709-22709.7 Hz 23509-23509.7 Hz 23526-23526.7 Hz 23560-23560,7 Hz 23589-23589.7 Hz
23957-23957.7 Hz 24014-24014.7 Hz 24117-24117.7 Hz 24869-24869.7 Hz 25449-25449.7 Hz
25454-25454.7 Hz 26722-26722.7 Hz 26861-26861.7 Hz 30942-30942.7 Hz 31713-31713.7 Hz
32866-32866.7 Hz 32870-32870.7 Hz 33765-33765.7 Hz 34405-34405.7 Hz 34562-34562.7 Hz
34984-34984.6 Hz 36410-36410.7 Hz 38483-38483.7 Hz 38659-38659.7 Hz 39035-39035.7 Hz
39223-39223.7 Hz 39510-39510.7 Hz 39729-39729.7 Hz 40693-40693.7 Hz 41244-41244.7 Hz
41574-41574.7 Hz 42913-42913.7 Hz 42923-42923.7 Hz 43243-43243.7 Hz 43413-43413.7 Hz
43542-43542.7 Hz 43603-43603.7 Hz 44742-44742.7 Hz 47693.4-47694 Hz 51592-51592.7 Hz
53947-53947.7 Hz 55072-55072.7 Hz 56093-56093.7 Hz 59089-59089.7 Hz 66969-66969.7 Hz
67683-67683.7 Hz 76537-76537.7 Hz 78229-78229.7 Hz 82845-82845.7 Hz 83612-83612.7 Hz
84086-84086.7 Hz 91245-91245.7 Hz 92361.3-92362 Hz 93332-93332.7 Hz 93530-93530.7 Hz
94968.3-94969 Hz 99281-99281.7 Hz 99846-99846.7 Hz
Example 10: Treatment of cholangiocarcinoma
[00208] Cholangiocarcinoma may be treated according to the methods disclosed herein by the application of cholangiocarcinoma spécifie amplitude-modulated frequencies.
Cholangiocarcinoma spécifie frequencies are provided below in Table 42.
[00209] Table 42: Amplitude-modulated frequencies discovered to be effective for treatment of cholangiocarcinoma
334-334.7 Hz 380-380.7 Hz 410-410.7 Hz 427-427.6 Hz 434-434.7 Hz
476-476.7 Hz 527-527.7 Hz 560-560.7 Hz 624-624.7 Hz 642.4-643 Hz
657-657.7 Hz 677.4-678 Hz 728-728.7 Hz 806-806.6 Hz 809-809.7 Hz
845-845.7 Hz 920-920.7 Hz 961-961.7 Hz 963.8-964.25Hz 964.3-964.8 Hz
974.4-975 Hz 1156.3-1157 Hz 1157-1157,7 Hz 1755-1755.7 Hz 1873-1873.7 Hz
1967-1967.7 Hz 2017.4-2018 Hz 2021-2021,7 Hz 2023-2023.7 Hz 2035-2035.7 Hz
2053-2053.7 Hz 2065-2065.7 Hz 2083-2083.7 Hz 2094-2094.7 Hz 2111-2111.7 Hz
2128-2128.7 Hz 2278-2278.7 Hz 2284-2284.7 Hz 2308-2308.7 Hz 2324-2324.7 Hz
2338-2338.7 Hz 2362-2362.7 Hz 2381-2381.7 Hz 2419-2419.7 Hz 2425-2425.7 Hz
2430-2430.7 Hz 2431-2431.6 Hz 2471-2471.7 Hz 2480-2480.7 Hz 2522-2522.7 Hz
2636-2636.7 Hz 2669-2669.7 Hz 2679-2679.7 Hz 2685-2685.6 Hz 2716-2716.6 Hz
2743.4-2744 Hz 2835-2835.7 Hz 2854-2854.7 Hz 2865-2865.7 Hz 2873.3-2874 Hz
2886-2886.7 Hz 3009-3009.7 Hz 3020-3020.7 Hz 3042-3042.6 Hz 3076.3-3077 Hz
3104.3-3105 Hz 3135-3135.7 Hz 3143-3143.7 Hz 3160.4-3161 Hz 3167-3167.7 Hz
3206-3206.7 Hz 3255-3255.7 Hz 3267-3267.7 Hz 3269-3269.7 Hz 3330.4-3331 Hz
3516-3516.7 Hz 3531-3531.7 Hz 3549-3549.7 Hz 3564-3564.7 Hz 3572-3572.7 Hz
3576-3576.7 Hz 3619-3619.7 Hz 3630-3630.7 Hz 3637.7-3638.3 Hz 3644-3644.7 Hz
3696-3696.7 Hz 3749.3-3750 Hz 3947-3947.7 Hz 3954-3954.7 Hz 4013.4-4014 Hz
4079.4-4080 Hz 4123.4-4124 Hz 4281-4281.7 Hz 4289-4289.7 Hz 4312.4-4313 Hz
4418-4418.7 Hz 4426-4426.7 Hz 4441-4441.7 Hz 4685-4685.6 Hz 4707-4707.7 Hz
4715-4715.7 Hz 4732-4732.7 Hz 4732-4732.7 Hz 4748-4748.7 Hz 4767-4767.7 Hz
4812-4812.7 Hz 4821-4821.7 Hz 4873-4873.7 Hz 4874-4874.7 Hz 4876-4876.7 Hz
4941-4941.7 Hz 5209.4-5210 Hz 5229-5229.7 Hz 5243-5243.7 Hz 5247-5247.7 Hz
5262-5262.7 Hz 5271-5271.7 Hz 5387.3-5388 Hz 5573-5573.7 Hz 5671-5671.7 Hz
5679-5679.7 Hz 5966-5966.7 Hz 5976.3-5977 Hz 6064-6064.7 Hz 6086-6086.7 Hz
6180-6180.7 Hz 6479.4-6480 Hz 6513-6513.7 Hz 6711-6711.7 Hz 6779-6779.7 Hz
6915.3-6916 Hz 7019-7019.7 Hz 7043-7043.7 Hz 7130-7130.7 Hz 7213-7213.7 Hz
7228.3-7229 Hz 7234-7234.7 Hz 7246-7246.7 Hz 7268-7268.7 Hz 7367-7367.7 Hz
7482-7482.7 Hz 7510.4-7511 Hz 7680.3-7681 Hz 7862-7862.7 Hz 7935-7935.7 Hz
8012.3-8013 Hz 8013-8013.7 Hz 8026-8026.7 Hz 8028-8028.7 Hz 8028-8028.7 Hz
8055.4-8056 Hz 8072-8072.7 Hz 8074-8074.7 Hz 8079-8079.7 Hz 8141-8141.7 Hz
8336-8336.7 Hz 8394.3-8395 Hz 8421-8421.7 Hz 8432-8432.7 Hz 8452-8452.7 Hz
8492-8492.7 Hz 8509.4-8510 Hz 8542-8542.7 Hz 8779-8779.7 Hz 8789.3-8790 Hz
8818-8818.7 Hz 8852-8852.7 Hz 8993-8993.7 Hz 9023-9023.7 Hz 9112-9112.7 Hz
9332-9332.7 Hz 9753-9753.7 Hz 9846-9846.7 Hz 10140-10140.7 Hz 10317-10317.7 Hz
10362-10362.7 Hz 10488-10488.7 Hz 10661-10661.7 Hz 10665.4-10666 Hz 10690-10690.7 Hz
10866-10866.7 Hz 11081-11081.7 Hz 11109.3-11110 Hz 11219-11219.7 Hz 11582-11582.7 Hz
11619-11619.7 Hz 11637-11637.7 Hz 11802.3-11803 Hz 11809-11809.7 Hz 11831-11831.7 Hz
11872-11872.7 Hz Γ1904.3-11905 Hz 12024.3-12025 Hz 12228-12228.7 Hz 12247-12247.7 Hz
12260.4-12261 Hz 12274-12274.7 Hz 12682-12682.7 Hz 12752-12752.7 Hz 12783-12783.7 Hz
12785-12785.7 Hz 13127-13127.7 Hz 13457-13457.7 Hz 13609-13609.7 Hz 13734-13734.7 Hz
13747-13747.7 Hz 13755-13755.7 Hz 13760-13760.7 Hz 13761-13761.7 Hz 13767-13767.7 Hz
13981-13981.7 Hz 14005-14005.7 Hz 14027-14027.7 Hz 14070-14070.7 Hz 14078-14078.7 Hz
14356-14356.7 Hz 14531-14531.7 Hz 14545-14545.7 Hz 14564-14564.7 Hz 14828-14828.7 Hz
14867-14867.7 Hz 14913.4-14914 Hz 14940-14940.7 Hz 15173-15173.7 Hz 15224-15224.7 Hz
15244-15244.7 Hz 15432-15432.7 Hz 15460-15460.7 Hz 15515-15515.7 Hz 15539-15539.7 Hz
15550.4-15551 Hz 15857-15857.7 Hz 16082-16082.7 Hz 16515-16515.7 Hz 17636-17636.7 Hz
17673-17673.7 Hz 18087-18087.7 Hz 18222-18222.7 Hz 18521-18521.7 Hz 18585-18585.7 Hz
19347-19347.7 Hz 19889-19889.7 Hz 21466-21466.7 Hz 21567-21567.7 Hz 21844-21844.7 Hz
21870-21870.7 Hz 21894-21894.7 Hz 22073-22073.7 Hz 22119-22119.7 Hz 22411-22411.7 Hz
22437-22437.7 Hz 22479-22479.7 Hz 22582-22582.7 Hz 22730-22730.6 Hz 22832-22832.7 Hz
22863-22863.7 Hz 23237-23237.7 Hz 23261-23261.7 Hz 23444-23444.7 Hz 26212-26212.7 Hz
27291-27291.7 Hz 31051-31051.7 Hz 35296-35296.7 Hz 37680-37680.7 Hz 39053-39053.7 Hz
39183-39183.7 Hz 39423-39423.7 Hz 40111-40111.7 Hz 41557-41557.7 Hz 42293-42293.7 Hz
43172-43172.7 Hz 43379-43379.7 Hz 44855-44855.7 Hz 45163-45163.7 Hz 45362-45362.7 Hz
46666-46666.7 Hz 46673-46673.7 Hz 46689-46689.6 Hz 51008-51008.7 Hz 52063-52063.7 Hz
52786-52786.7 Hz 52912-52912.7 Hz 55723-55723.7 Hz 61287-61287.7 Hz 61789-61789.7 Hz
71635-71635.7 Hz 86521-86521.7 Hz 87798.3-87799 Hz 88898-88898.7 Hz 91271-91271.7 Hz
92787-92787.7 Hz
Example 11: Treatment of mesothelioma
[00210] Mesothelioma may be treated according to the methods disclosed herein by the application of mesothelioma spécifie amplitude-modulated frequencies. Mesothelioma spécifie frequencies are provided below in Table 43.
[00211] Table 43: Amplitude-modulated frequencies discovered to be effective for treatment of
5 mesothelioma.
262-262.7 Hz 412-412.7 Hz 418-418.7 Hz 429-429.7 Hz 441-441.7 Hz
442-442.7 Hz 465-465.7 Hz 485-485.7 Hz 517-517.7 Hz 556-556.7 Hz
581-581.7 Hz 612-612.7 Hz 626-626.7 Hz 638-638.7 Hz 664-664.7 Hz
694.3-695 Hz 708.3-709 Hz 734.4-735 Hz 761-761.7 Hz 764-764.7 Hz
776-776.7 Hz 806-806.6 Hz 831-831.7 Hz 883-883.7 Hz 1191-1191.7 Hz
1591-1591.7 Hz 2475.4-2476 Hz 2581-2581.7 Hz 2749-2749.7 Hz 2988-2988.7 Hz
3042-3042.6 Hz 3131-3131.7 Hz 3193-3193.7 Hz 3240-3240.7 Hz 3335-3335.7 Hz
3371-3371.7 Hz 3518-3518.7 Hz 3523-3523.7 Hz 3530-3530.7 Hz 3556-3556.7 Hz
3621-3621.7 Hz 3656-3656.7 Hz 3674-3674.7 Hz 3681.7-3682.3 Hz 3817-3817.7 Hz
3833-3833.7 Hz 3877-3877.7 Hz 3948-3948.7 Hz 3958-3958.6 Hz 4044-4044.7 Hz
4190-4190.7 Hz 4261-4261.7 Hz 4330-4330.7 Hz 5496-5496.7 Hz 5640.4-5641 Hz
6416.3-6417 Hz 6441-6441.7 Hz 6717-6717.7 Hz 6758-6758.7 Hz 6783-6783.7 Hz
7110-7110.7 Hz 7140-7140.7 Hz 7154-7154.7 Hz 7156-7156.7 Hz 7253-7253.7 Hz
7283-7283.7 Hz 7546-7546.7 Hz 7725-7725.7 Hz 8386-8386.7 Hz 8562.4-8563 Hz
8810-8810.7 Hz 8827.4-8828 Hz 8843-8843.7 Hz 8859.3-8860 Hz 8863-8863.7 Hz
8877-8877.7 Hz 8881-8881.7 Hz 9075-9075.7 Hz 9929-9929.7 Hz 9947.9947.7 Hz
9970-9970.7 Hz 11023-11023.7 Hz 11031-11031.7 Hz 11042-11042.7 Hz Γ1046-11046.7 Hz
11074-11074.7 Hz 11083-11083.7 Hz 11124-11124.7 Hz 11540-11540.7 Hz 11831-11831.7 Hz
11929-11929.7 Hz 11956-11956.7 Hz 12267-12267.7 Hz 12929-12929.7 Hz 13674-13674.7 Hz
13742-13742.7 Hz 14285-14285.7 Hz 14947-14947.7 Hz 15531-15531.7 Hz 17737-17737.7 Hz
17757-17757.7 Hz 18121-18121.7 Hz 18126-18126.7 Hz 18140-18140.7 Hz 18921-18921.7 Hz
19406-19406.7 Hz 19476-19476.7 Hz 19577-19577.7 Hz 20634-20634.7 Hz 21372-21372.7 Hz
22411-22411.7 Hz 22519-22519.7 Hz 22538-22538.7 Hz 22548-22548.7 Hz 23111-23111.7 Hz
23921-23921.7 Hz | 24112-24112.7 Hz 24146-24146.7 Hz 39153-39153.7 Hz
Example 12: Treatment of thyroid cancer
[00212] Thyroid cancer may be treated according to the methods disclosed herein by the application of thyroid cancer spécifie amplitude-modulated frequencies. Thyroid cancer spécifie frequencies are provided below in Table 44.
[00213] Table 44: Amplitude-modulated frequencies discovered to be effective for treatment of thyroid cancer.
834-834.7 Hz 836-836.7 Hz 845-845.7 Hz 1213-1213.7 Hz 1220-1220.7 Hz
1252-1252.7 Hz 1815-1815.7 Hz 1966-1966.7 Hz 2050-2050.7 Hz 2313-2313.7 Hz
2318-2318.7 Hz 2320-2320.7 Hz 2328-2328.7 Hz 2336-2336.7 Hz 2359-2359.7 Hz
2373-2373.7 Hz 2380-2380.7 Hz 2425-2425.7 Hz 2429-2429.7 Hz 2436-2436.7 Hz
2513-2513.7 Hz 2629-2629.7 Hz 2653.7-2654.4 Hz 2830-2830.7 Hz 2834-2834.7 Hz
3030-3030.7 Hz 3056-3056.7 Hz 3609-3609.7 Hz 3646-3646.7 Hz 3674-3674.7 Hz
3694-3694.7 Hz 3908.7-3909.22Hz 3981-3981.7 Hz 4027-4027.7 Hz 4386.4-4387 Hz
4425.7-4426.22Hz 4792-4792.7 Hz 4844-4844.7 Hz 4870-4870.7 Hz 5259-5259.7 Hz
5510-5510.7 Hz 5533-5533.7 Hz 5714-5714.7 Hz 5741-5741.7 Hz 5742-5742.7 Hz
5752-5752.7 Hz 5766-5766.7 Hz 6392-6392.7 Hz 6423-6423.7 Hz 6781-6781.7 Hz
6832-6832.7 Hz 6864-6864.7 Hz 7404.4-7405 Hz 7526-7526.6 Hz 7646-7646.7 Hz
7652-7652.7 Hz 7913-7913.7 Hz 8217.4-8218 Hz 8251-8251.7 Hz 8347-8347.7 Hz
8731-8731.7 Hz 8740-8740.7 Hz 8749-8749.7 Hz 8814-8814.7 Hz 9169-9169.7 Hz
9506-9506.7 Hz 10159-10159.7 Hz 10395-10395.7 Hz 10541-10541.7 Hz 10830-10830.7 Hz
10844-10844.7 Hz 10878-10878.7 Hz 1Ü993-10993.7 Hz 11117-11117.7 Hz 11779-11779.7 Hz
11867-11867.7 Hz 12302-12302.7 Hz 12356-12356.7 Hz 13117-13117.7 Hz 13373-13373.7 Hz
13679-13679.7 Hz 13694-13694.7 Hz 14111-14111.7 Hz 14116-14116.7 Hz 14156-14156.7 Hz
14174-14174.7 Hz 14281-14281.7 Hz 14523-14523.7 Hz 14585-14585.7 Hz 14690-14690.7 Hz
14716-14716.7 Hz 14912-14912.7 Hz 14974-14974.7 Hz 15223-15223.7 Hz 15236-15236.7 Hz
15329-15329.7 Hz 15615-15615.7 Hz 15867-15867.7 Hz 15919-15919.7 Hz 15942-15942.7 Hz
16096-16096.7 Hz 18040-18040.7 Hz 18182-18182.7 Hz 18211-18211.7 Hz 18246-18246.7 Hz
18274-18274.7 Hz 18411-18411.7 Hz 18454-18454.7 Hz 18462-18462.7 Hz 18596-18596.7 Hz
19365-19365.7 Hz 19419-19419.7 Hz 19715-19715.7 Hz 19744-19744.7 Hz 19823-19823.7 Hz
20229-20229.7 Hz 20284-20284.7 Hz 20513-20513.7 Hz 20747-20747.7 Hz 21963-21963.7 Hz
22338-22338.7 Hz 22344-22344.7 Hz 22350-22350.7 Hz 22422-22422.7 Hz 22484-22484.7 Hz
22932-22932.7 Hz 23012-23012.7 Hz 23044-23044.7 Hz 23216-23216.7 Hz 23659-23659.7 Hz
23730-23730.7 Hz 24060-24060.7 Hz 24085-24085.7 Hz 26044-26044.7 Hz 26343-26343.7 Hz
27214-27214.7 Hz 28361-28361.7 Hz 33366-33366.7 Hz 33414-33414.7 Hz 33553-33553.7 Hz
34614-34614.7 Hz 35826-35826.7 Hz 40133-40133.7 Hz 40394-40394.7 Hz 40896-40896.7 Hz
40899-40899.7 Hz 41424-41424.7 Hz 41534-41534.7 Hz 41859-41859.7 Hz 41861-41861.7 Hz
42402-42402.7 Hz 43851-43851.7 Hz 44162-44162.7 Hz 44692-44692.7 Hz 45393-45393.7 Hz
45526-45526.7 Hz 46282-46282.7 Hz 46285-46285.7 Hz 47036-47036.7 Hz 48314-48314.7 Hz
48535-48535.7 Hz 52097-52097.7 Hz 54293-54293.7 Hz 54297-54297.7 Hz 55592-55592.7 Hz
57927-57927.7 Hz 59907-59907.7 Hz 65586-65586.7 Hz 67697-67697.6 Hz 71204-71204.7 Hz
71447-71447.7 Hz 74017-74017.7 Hz 76227-76227.7 Hz 76659-76659.7 Hz 82024-82024.7 Hz
Example 13: Treatment of prostate cancer
[00214] Prostate cancer may be treated according to the methods disclosed herein by the application of prostate cancer spécifie amplitude-modulated frequencies. Prostate cancer spécifie frequencies are provided beiow in Table 45.
[00215] Table 45; Amplitude-modulated frequencies discovered to be effective for treatment of prostate cancer.
408-408.7 Hz 429.7-430.3 Hz 561-561.7 Hz 568-568.7 Hz 572-572.7 Hz
631-631.7 Hz 709-709.7 Hz 717-717.7 Hz 733-733.7 Hz 810-810.7 Hz
817-817.7 Hz 830-830.7 Hz 1668-1668.7 Hz 1808-1808.6 Hz 2483-2483.7 Hz
2518-2518.7 Hz 2824-2824.7 Hz 3207-3207.7 Hz 3245-3245.7 Hz 3251-3251.7 Hz
3266.3-3267 Hz 3279.3-3280 Hz 3529-3529.7 Hz 3562-3562.7 Hz 3571-3571.7 Hz
3627-3627.7 Hz 3661-3661.7 Hz 3731-3731.7 Hz 3743-3743.7 Hz 3756-3756.7 Hz
3787-3787.7 Hz 3962-3962.7 Hz 4152-4152.7 Hz 4409-4409.7 Hz 4476-4476.7 Hz
4806-4806.7 Hz 4809-4809.7 Hz 4823-4823.7 Hz 4841-4841.7 Hz 4948-4948,7 Hz
4998-4998.7 Hz 5336-5336.7 Hz 5414-5414.7 Hz 5884-5884.7 Hz 6Γ17-6Γ17.7 Hz
6252-6252.7 Hz 6329-6329.7 Hz 6333-6333.7 Hz 6748-6748.7 Hz 6782-6782.7 Hz
7112-7112.7 Hz 7424-7424.7 Hz 7655-7655.7 Hz 7906-7906.7 Hz 7910-7910.7 Hz
7923-7923.7 Hz 8373-8373.7 Hz 8445-8445.7 Hz 8765-8765.7 Hz 8829-8829.7 Hz
8852-8852.7 Hz 8877-8877.7 Hz 9078-9078.7 Hz 9512-9512.7 Hz 9635-9635.7 Hz
9681-9681.7 Hz 9886-9886.7 Hz 10735-10735.7 Hz 10748-10748.7 Hz 10781-10781.7 Hz
10813.2-10813.8 Hz 11134-11134.7 Hz, 11155-11155.7 Hz 11164-11164.7 Hz 11264-11264.7 Hz
11381-11381.7 Hz 11416-11416.7 Hz 11438-11438.7 Hz 11469-11469.7 Hz 11628-11628.7 Hz
12330-12330.7 Hz 12391-12391.7 Hz 12880-12880.7 Hz 13467-13467.7 Hz 13562-13562.6 Hz
13805-13805,7 Hz 13828-13828.7 Hz 13834-13834.7 Hz 13857.4-13858 Hz 13858-13858.7 Hz
13871-13871.7 Hz 14009-14009.7 Hz 14034-14034.7 Hz 14153-14153.7 Hz 14489-14489.7 Hz
15071-15071.7 Hz 15149-15149.7 Hz 15233-15233.7 Hz 15253-15253.7 Hz 15263-15263.7 Hz
15435-15435.7 Hz 15545-15545.7 Hz 16176-16176.7 Hz 16329-16329.7 Hz 16679-16679.7 Hz
16804-16804.7 Hz 16821-16821.7 Hz 17333-17333.7 Hz 17435-17435.7 Hz 17974-17974.7 Hz
18260-18260.7 Hz 18641-18641.7 Hz 18831-18831.7 Hz 18884-18884.7 Hz 19453-19453.7 Hz
20948-20948.7 Hz 21119-21119.7 Hz 21167-21167.7 Hz 21636-21636.7 Hz 22312-22312.7 Hz
22361-22361.7 Hz 22419-22419.7 Hz 22430-22430.7 Hz 22443-22443.7 Hz 22459-22459.7 Hz
22879-22879.7 Hz 23117-23117.7 Hz 23137-23137.7 Hz 23412-23412.7 Hz 23548-23548.7 Hz
23686-23686.7 Hz 26142-26142.7 Hz 26465-26465.7 Hz 27328-27328.6 Hz 28653-28653.7 Hz
28744-28744.7 Hz 31572-31572.7 Hz 31633-31633.7 Hz 41062-41062.7 Hz 41325-41325.7 Hz
41473-41473.7 Hz 48683-48683.7 Hz 48793-48793.7 Hz 87507-87507.7 Hz
Example 14: Treatment of rhabdomyosarcoma
[00216] Rhabdomyosarcoma may be treated according to the methods disclosed herein by the application of rhabdomyosarcoma spécifie amplitude-modulated frequencies.
Rhabdomyosarcoma spécifie frequencies are provided below in Table 46.
[00217] Table 46: Amplitude-modulated frequencies discovered to be effective for treatment of rhabdomyosarcoma.
304-304.7 Hz 331-331.7 Hz 410-410.7 Hz 420-420,7 Hz 429-429.7 Hz
434-434.7 Hz 461-461.7 Hz 537.4-538 Hz 560-56Ü.7 Hz 572-572.7 Hz
605-605.7 Hz 611-611.7 Hz 618.3-619 Hz 626-626.7 Hz 717-717.7 Hz
776-776.7 Hz 779-779.7 Hz 810-810,7 Hz 814-814.7 Hz 826-826.7 Hz
836.4-837 Hz 843-843.7 Hz 843-843.7 Hz 1314-1314.7 Hz 1411-1411.7 Hz
1467-1467.7 Hz 1785-1785.7 Hz 1816-1816.7 Hz 1903-1903.7 Hz 2073.3-2074 Hz
2155-2155.7 Hz 2287-2287,7 Hz 2381-2381.7 Hz 2542-2542.7 Hz 2711-2711.6 Hz
2854-2854.6 Hz 2911-2911.7 Hz 3085.7-3086.3 Hz 3121-3121.7 Hz 3232-3232.7 Hz
3438-3438.7 Hz 3518-3518.7 Hz 3544-3544.7 Hz 3569-3569.7 Hz 3618-3618.7 Hz
3910-3910.7 Hz 3917-3917.7 Hz 4198-4198.7 Hz 4233.3-4234 Hz 4241-4241.7 Hz
266.3-267 Hz 4337-4337.7 Hz 4358-4358.7 Hz 4424-4424.7 Hz 4436-4436.7 Hz
4485-4485.7 Hz 4731-4731.7 Hz 4749-4749.7 Hz 4776-4776.7 Hz 5151-5151.7 Hz
5521-5521.7 Hz 5545.3-5546 Hz 5577.3-5578 Hz 5618-5618.7 Hz 5631-5631.7 Hz
5696-5696.7 Hz 6058-6058.7 Hz 6443-6443.7 Hz 6472-6472.6 Hz 6558-6558.7 Hz
6651-6651.7 Hz 6730-6730.7 Hz 7168.4-7169 Hz 7406-7406.7 Hz 7440-7440.7 Hz
7452.3-7453 Hz 7649-7649.7 Hz 7808-7808.7 Hz 8542-8542.7 Hz 8546-8546.7 Hz
8562-8562.7 Hz 8576-8576.7 Hz 8698-8698.7 Hz 8881-8881.7 Hz 9040-9040.7 Hz
9074-9074.7 Hz 9189-9189.6 Hz 9484.3-9485 Hz 9851-9851.7 Hz 9943.4-9944 Hz
10870-10870.7 Hz 10891-10891.7 Hz 12086-12086.7 Hz 12648-12648.7 Hz 15195-15195.7 Hz
17316-17316.7 Hz 18021-18021.7 Hz 18567-18567.7 Hz 19384-19384.7 Hz 20097-20097.7 Hz
20278.4-20279 Hz 21854-21854.7 Hz 21890-21890.7 Hz 24198-24198.7 Hz 24413-24413.7 Hz
24789-24789.7 Hz 26534-26534.7 Hz 27713-27713.7 Hz 28222-28222.7 Hz 40489-40489.7 Hz
40762-40762.7 Hz 41279-41279.7 Hz 42923-42923.7 Hz 43166-43166.7 Hz 43692-43692.7 Hz
48583-48583.7 Hz 49434-49434.7 Hz 66553-66553.7 Hz 79658-79658.7 Hz
Example 15: Treatment of colorectal cancer
[00218] Colorectal cancer may be treated according to the methods disclosed herein by the application of colorectal cancer spécifie amplitude-modulated frequencies. Colorectal cancer spécifie frequencies are provided below in Table 47.
[00219] Table 47: Amplitude-modulated frequencies discovered to be effective for treatment of colorectal cancer.
605-605.7 Hz 826-826.7 Hz 834-834.7 Hz 841.9-842.6 Hz 1808-1808.6 Hz
1928-1928.7 Hz 1989-1989.7 Hz 2439.7-2440.3Hz 2714-2714.7 Hz 2747-2747.7 Hz
2759-2759.7 Hz 2S07-2807.7 Hz 2826-2826.7 Hz 2981-2981.7 Hz 3209-3209.7 Hz
3213-3213.7 Hz 3244-3244.7 Hz 3261-3261.7 Hz 3548-3548.7 Hz 3634-3634.7 Hz
3646.4-3647 Hz 3915-3915.7 Hz 3922-3922.7 Hz 3940-3940.7 Hz 3946-3946.7 Hz
4135-4135.7 Hz 4155-4155.7 Hz 4224-4224.7 Hz 4241-4241.7 Hz 4283-4283.7 Hz
4323-4323.7 Hz 4438.7-4439.2Hz 4447-4447.7 Hz 4708-4708.7 Hz 4713-4713.7 Hz
4718-4718.7 Hz 4718-4718.7 Hz 4722-4722.7 Hz 4776-4776.7 Hz 4850-4850.7 Hz
4874-4874.7 Hz 5205-5205.7 Hz 5209-5209.7 Hz 5209-5209.7 Hz 5221-5221.7 Hz
5232-5232.7 Hz 5265-5265.7 Hz 5427-5427.7 Hz 5484.4-5485 Hz 6074-6074.7 Hz
6112-6112.7 Hz 6159-6159.7 Hz 6361-6361.7 Hz 6438-6438.7 Hz 6468-6468.7 Hz
6537-6537.7 Hz 6648-6648.7 Hz 6869-6869.7 Hz 6878-6878.7 Hz 6914-6914.7 Hz
6974-6974.7 Hz 6982-6982.7 Hz 6986-6986.7 Hz 7109-7109.7 Hz 7117-7117.7 Hz
7137-7137.7 Hz 7149-7149.7 Hz 7191.7-7192.3Hz 7531-7531.7 Hz 7560-7560.7 Hz
7879-7879.7 Hz 7936-7936.7 Hz 7970-7970.7 Hz 7994-7994.7 Hz 8038.4-8039 Hz
8413-8413.7 Hz 8438-8438.7 Hz 8467-8467.7 Hz 8771-8771.7 Hz 8809-8809.7 Hz
8889-8889.7 Hz 9071-907L7 Hz 9084-9084.7 Hz 9731-9731.7 Hz 10566-10566.7 Hz
10831.7-10832.1 Hz 10845-10845.7 Hz 10859-10859.7 Hz 10906-10906.7 Hz 10947-10947.7 Hz
10974-10974.7 Hz 11110-11110.7 Hz 11225-11225.7 Hz 11234-11234.7 Hz 11255-11255.7 Hz
11387-11387.7 Hz 11530-11530.7 Hz 11576-11576.7 Hz 11621-11621.7 Hz 11630-11630.7
11638-11638.7 Hz 11681-11681.7 Hz 11911-11911.7 Hz 11934-11934.7 Hz 11949-11949.7 Hz
12182-12182.7 Hz 12373-12373.7 Hz 12575-12575.7 Hz 12589-12589.7 Hz 12617-12617.7 Hz
12629-12629.7 Hz 12637-12637.7 Hz 12645-12645.7 Hz 13418-13418.7 Hz 13475-13475.7 Hz
13611-13611.7 Hz 13615-13615.7 Hz 13670-13670.7 Hz 13717-13717.7 Hz 13736-13736.7 Hz
13742-13742.7 Hz 13773-13773.7 Hz 13775-13775.7 Hz 13978.3-13979 Hz 14182-14182.7 Hz
14417-14417.7 Hz 14422-14422.7 Hz 14441-14441.7 Hz 14443-14443.7 Hz 14570-14570.7 Hz
14621-14621.7 Hz 14630-14630.7 Hz 14671-14671.7 Hz 14674-14674.7 Hz 14863-14863.7 Hz
14877-14877.7 Hz 14911-14911.7 Hz 14957-14957.7 Hz 14982-14982.7 Hz 15109-15109.7 Hz
15133-15133.7 Hz 15154-15154.7 Hz 15230-15230.7 Hz 15250-15250.7 Hz 15278-15278.7 Hz
16274-16274.7 Hz 17106-17106.7 Hz 17123-17123.7 Hz 17472-17472.7 Hz 17515-17515.7 Hz
17578.4-17579 Hz 17808-17808.7 Hz 17825-17825.7 Hz 18157-18157.7 Hz 18171-18171.7 Hz
18294-18294.7 Hz 18372-18372.7 Hz 18375-18375.7 Hz 18396-18396.7 Hz 18533-18533.7 Hz
18635-18635.7 Hz 19342-19342.7 Hz 19437-19437.7 Hz 19447-19447.7 Hz 19829-19829.7 Hz
20173-20173.7 Hz 20499-20499.7 Hz 21389-21389.7 Hz 21490-21490.7 Hz 21663-21663.7 Hz
21833-21833.7 Hz 22167-22167.7 Hz 22423.4-22424 Hz 22559.3-22560 Hz 22743-22743.7 Hz
23246-23246.7 Hz 23249-23249.7 Hz 23259-23259.7 Hz 23344-23344.7 Hz 23624-23624.7 Hz
23667-23667.7 Hz 24142-24142.7 Hz 26113-26113.7 Hz 26403-26403.7 Hz 28212-28212.7 Hz
28272-28272.7 Hz 28537-28537.7 Hz 30075-30075.7 Hz 30373-30373.7 Hz 31847-31847.7 Hz
33546-33546.7 Hz 35324-35324.7 Hz 35543-35543.7 Hz 42544-42544.7 Hz 42692.3-42693 Hz
42812-42812.7 Hz 42813-42813.7 Hz 43162-43162.7 Hz 43325-43325.7 Hz 44652-44652.7 Hz
46340-46340.7 Hz 46746-46746.7 Hz 48653-48653.7 Hz 51946-51946.7 Hz 52752-52752.7 Hz
80715-80715.7 Hz 94494.94494.7 Hz
[00220] Conclusions:
[00221] The treatment of cancer according to the method and devices described herein is a safe and promising novel treatment modality for multiple types of cancer. Following extended trials, it has been determined that application to subjects of the frequencies provided herein enhances the 5 efficacy of treatment and yields therapeutic effects in patients whose tumors hâve become résistant to therapy. It is accordingly preferred that most (i.e., over 50%) or ail of the determined listed frequencies be applied to the subject. The mechanism of including additional frequencies is attributed to either or both of inter-active synergism between applied frequencies or between cells which hâve been influenced by the treatment and additive effects of the additional frequencies.
[00222] Of further note is the fact that different patients suffering from the same type of tumor cell growth practically exhibit the above-mentioned physiological responses at the same welldefined AM frequencies. Furthermore, AM frequencies which differ only very slightly (less than 0.001% at higher frequencies) from the frequencies listed, in general elicit reduced or no physiological response by subjects exposed to excitation at such very slightly different frequency.
In view of these déterminations, the electronic System of the présent invention may be adapted to screen a subject for physiological responses over a broad range of frequencies to détermine the presence or absence tumor cells and, if positive, then to note at which defined frequencies physiological responses are elicited. These frequencies will in general match with the defined frequencies listed in one of the Examples above or such further examples as may be developed and hence the nature of the tumor will be known. The electronic system of the invention is therefore a valuable diagnostic tool for diagnosing the presence or absence and identities of types of tumor cell growths or cancers. Furlhermore, the electronic System of the invention is of value for predicting whether a patient will benefit from the application of a given sériés of modulation frequencies. The System therefore possesses a capability of predicting responses to treatment, thereby enhancing the possîbility to select optimal modes of treatment.
[00223] The sequence of well-defined frequencies is preferably applied sequenlially for determîned perîods of time, e.g., 3 seconds for each frequency, but several frequencies may also be applied simultaneously or may be applied in any order or in a random order. This means that a cycle of application involving 180 frequencies would take nearly 10 minutes time. Advantageous effects may, however, also arise from applying îndîvîdual well-defined frequencies for dîfferîng time perîods, e.g., some for 3 seconds, some for 6 seconds, etc.
[00224] Therapeutic dosages to be applied to a subject suffering from the presence of tumor cell growth or cancer are determîned by the time of application of the low energy electromagnetic émissions to the subject and will dépend on the nature of the cancer and the overall condition of the subject. In general, however, greatest expérience has been gained in treating terminally ill subjects expected to survive no longer than about three months and who hâve agreed to discontinue alternative forms of cancer treatments such as chemo-therapy or radioactive treatment. In these severe cases, convenient times of treatment are recommended, e.g., 3 times 1 hour daîly treatment. However, with the use of alternative forms of application, i.e., other than by means of a mouth probe, continuons application is possible and may be désirable.
[00225] While the invention has been described with spécifie embodiments, other alternatives, modifications and variations will be apparent to those skilled in the art. Accordingly, it will be intended to include all such alternatives, modifications, and variations within the spirit and scope of the appended daims.

Claims (16)

  1. CLA1MS
    1. An apparatus for treating a subject suffering from cancer, the apparatus comprising:
    20 a conductive applicator configured to apply to the subject low energy high frequency radiation, wherein the low energy high frequency radiation comprises one or more amplitudemodulated output signais; and a frequency synthesizer coupled to the conductive applicator and configured to generale the one or more amplitude-modulated output signais by generating:
    25 a carrier frequency signal having a carrier frequency from about IKHz to
    5000 MHz; and amplitude modulation frequency signais having amplitude modulation frequencies from about 0.1 Hz to about 150,000 Hz, wherein the amplitude modulation frequencies are selected to be cancer-specific frequencies;
    30 wherein the amplitude modulation frequency signais comprise 10 or more, 15 or more, or 20 or more, 25 or more, or 30 or more, 35 or more, or 40 or more, 45 or more, or 50 or more, 60 or more, 70 or more, 80 or more, 90 or more, or 100 or more of cancer-specific amplitude modulation frequencies selected from Table A:
    Table A
    262-262.7 Hz 266.3-267 Hz 295-295.6 Hz 334-334.7 Hz
    374-374.7 Hz 408-408.7 Hz 415-415.7 Hz 418-418.7 Hz
    419.8-420.4 Hz 420-420.7 Hz 420.4-420.8 Hz 429-429.7 Hz
    429.7-430.3 Hz 439-439.7 Hz 441-441.7 Hz 442-442.7 Hz
    465-465.7 Hz 485-485.7 Hz 527-527.7 Hz 556-556.7 Hz
    561-561.7 Hz 568-568.7 Hz 572-572.7 Hz 581-581.7 Hz
    594-594.7 Hz 605-605.7 Hz 611-611.7 Hz 612-612.7 Hz
    624.32-624.8 Hz 626-626.7 Hz 627-627.7 Hz 631-631.7 Hz
    633-633.7 Hz 638-638.7 Hz 677.4-678 Hz 679-679.7 Hz
    709-709.7 Hz 717-717.7 Hz 727-727.7 Hz 733-733.7 Hz
    737-737.7 Hz 759-759.7 Hz 761-761.7 Hz 810-810.7 Hz
    811-811.7 Hz 817-817.7 Hz 826-826.7 Hz 829-829.7 Hz
    830-830.7 Hz 834-834.7 Hz 836-836.7 Hz 883-883.7 Hz
    959-959.7 Hz 961-961.7 Hz 963.8-964.25 Hz 964.5-965 Hz
    966-966.7 Hz 969-969.7 Hz 972-972.7 Hz 974.4-975 Hz
    977-977.7 Hz 996-996.7 Hz 1027-1027.7 Hz 1045-1045.7 Hz
    1157-1157.7 Hz 1179.2-1179.8Hz 1195-1195.7 Hz 1213-1213.7 Hz
    1220-1220.7 Hz 1252-1252.7 Hz 1314-1314.7 Hz 1336-1336.7 Hz
    1352-1352.7 Hz 1369-1369.7 Hz 1436-1436.7 Hz 1467-1467.7 Hz
    1622-1622.7 Hz 1652-1652.7 Hz 1668-1668.7 Hz 1728-1728.7 Hz
    1759-1759.7 Hz 1771.7-1772.3 Hz 1772.3-1772.8 Hz 1785-1785.7 Hz
    1808-1808.6 Hz 1815-1815.7 Hz 1823-1823.7 Hz 1858-1858.7 Hz
    1868-1868.7 Hz 1881-1881.7 Hz 1897-1897.7 Hz 1903-1903.7 Hz
    1914-1914.7 Hz 1928-1928.7 Hz 1963-1963.7 Hz 1966-1966.7 Hz
    1967-1967.7 Hz 1973-1973.7 Hz 1989-1989.7 Hz 2021-2021.7 Hz
    2023-2023.7 Hz 2035-2035.7 Hz 2044-2044.7 Hz 2065-2065.7 Hz
    2094-2094.7 Hz 2111-2111.7 Hz 2128-2128.7 Hz 2189-2189.7 Hz
    2284-2284.7 Hz 2287-2287.7 Hz 2313-2313.7 Hz 2321-2321.7 Hz
    2328-2328.7 Hz 2346-2346.7 Hz 2359-2359.7 Hz 2372.3-2372.8 Hz
    2373-2373.7 Hz 2380-2380.7 Hz 2429-2429.7 Hz 2439.7-2440.3 Hz
    2455-2455.7 Hz 2459-2459.7 Hz 2469.2-2469.7Hz 2483-2483.7 Hz
    2513-2513.7 Hz 2518-2518.7 Hz 2612-2612.7 Hz 2627-2627.7 Hz
    2629-2629.7 Hz 2632-2632.7 Hz 2636-2636.7 Hz 2647-2647.7 Hz
    2648-2648.7 Hz 2653.3-2654 Hz 2653.7-2654.4Hz 2679-2679.7 Hz
    2697-2697.7 Hz 2706-2706.7 Hz 2707-2707.7 Hz 2714-2714.7 Hz
    2720.3-2721 Hz 2726-2726.7 Hz 2738-2738.7 Hz 2747-2747.7 Hz
    2754-2754.7 Hz 2759-2759.7 Hz 2762-2762.7 Hz 2774-2774.7 Hz
    2778-2778.7 Hz 2807-2807.7 Hz 2811-2811.7 Hz 2824-2824.7 Hz
    2825-2825.7 Hz 2826-2826.7 Hz 2830-2830.7 Hz 2834-2834.7 Hz __
    2836-2836.7 Hz 2840-2840.7 Hz 2842-2842.7 Hz 2854-2854.6 Hz____
    2854-2854.7 Hz 2858.8-2859.35Hz 2860-2860.7 Hz 2864-2864.7 Hz___
    2865-2865.7 Hz 2878-2878.7 Hz 2890-2890.7 Hz 2893-2893.7 Hz
    2940-2940.7 Hz 2971-2971.6 Hz 2975-2975.7 Hz 2981-2981.7 Hz
    3030-3030.7 Hz 3056-3056.7 Hz 3085.7-3086.3Hz 3121-3121.7 Hz___
    3133-3133.7 Hz 3135-3135.7 Hz 3143-3143.7 Hz 3171-3171.7 Hz
    3188-3188.7 Hz 3207-3207.7 Hz 3209-3209.7 Hz 3213-3213.7 Hz
    3218-3218.7 Hz 3222-3222.7 Hz 3227.3-3228 Hz 3228-3228.7 Hz
    3234-3234.7 Hz 3244-3244.7 Hz 3245-3245.7 Hz 3250.3-3250.8Hz
    3251-3251.7 Hz 3261-3261.7 Hz 3267-3267.7 Hz 3269-3269.7 Hz
    3272-3272.7 Hz 3279.3-3280 Hz 3280.6-3281.3 Hz 3281.6-3282.1 Hz
    3322-3322.7 Hz 3360-3360.7 Hz 3371-3371.7 Hz 3428-3428.7 Hz
    3446-3446.7 Hz 3466-3466.7 Hz 3522-3522.7 Hz 3529-3529.7 Hz
    3537-3537.7 Hz 3548-3548.7 Hz 3556-3556.7 Hz 3562-3562.7 Hz
    3571-3571.7 Hz 3595-3595.7 Hz 3609-3609.7 Hz 3618-3618.7 Hz
    3621-3621.7 Hz 3622.5-3623 Hz 3627-3627.7 Hz 3630-3630.7 Hz
    3631-3631.7 Hz 3633-3633.7 Hz 3634-3634.7 Hz 3637.7-3638.3Hz
    3644-3644.7 Hz 3646-3646.7 Hz 3646.4-3647 Hz 3656-3656.7 Hz
    3661-3661.7 Hz 3663-3663.7 Hz 3667-3667.7 Hz 3678-3678.7 Hz
    3681.7-3682.3Hz 3687-3687.7 Hz 3694-3694.7 Hz 3731-3731.7 Hz
    3743-3743.7 Hz 3749.3-3750 Hz 3756-3756.7 Hz 3762-3762.7 Hz
    3787-3787.7 Hz 3817-3817.7 Hz 3823-3823.7 Hz 3833-3833.7 Hz
    3839-3839.7 Hz 3842.4-3843 Hz 3854-3854.7 Hz 3877-3877.7 Hz
    3908.7-3909.22Hz 3910-3910.7 Hz 3915-3915.7 Hz 3922-3922.7 Hz
    3936-3936.7 Hz 3940-3940.7 Hz 3946-3946.7 Hz 3947-3947.7 Hz
    3948-3948.7 Hz 3954-3954.7 Hz 3958-3958.6 Hz 3962-3962.7 Hz
    3981-3981.7 Hz 4007-4007.7 Hz 4013-4013.7 Hz 4027-4027.7 Hz
    4048-4048.7 Hz 4055-4055.7 Hz 4135-4135.7 Hz 4148-4148.7 Hz
    4152-4152.7 Hz 4155-4155.7 Hz 4190-4190.7 Hz 4198-4198.7 Hz
    4224-4224.7 Hz 4233-4233.7 Hz 4249-4249.7 Hz 4281-4281.7 Hz
    4283-4283.7 Hz 4323-4323.7 Hz 4368.3-4369 Hz 4386.4-4387 Hz
    4409-4409.7 Hz 4410-4410.7 Hz 4418-4418.7 Hz 4425-4425.7 Hz
    4430-4430.7 Hz 4425.7-4426.22Hz 4438.7-4439.2 Hz 4441-4441.7 Hz
    4459-4459.7 Hz 4465-4465.7 Hz 4476-4476.7 Hz 4477.4-4478 Hz
    4523-4523.7 Hz 4548-4548.7 Hz 4580.11-4580.7Hz 4584-4584.7 Hz
    4621-4621.7 Hz 4632-4632.7 Hz 4637-4637.7 Hz 4657-4657.6 Hz
    4707-4707.7 Hz 4708-4708.7 Hz 4713-4713.7 Hz 4714-4714.7 Hz
    4722-4722.7 Hz 4723-4723.7 Hz 4725-4725.7 Hz 4731-4731.7 Hz
    4733-4733.7 Hz 4748-4748.7 Hz 4776-4776.7 Hz 4792-4792.7 Hz
    4805.3-4806 Hz 4806-4806.7 Hz 4809-4809.7 Hz 4812-4812.7 Hz
    4813-4813.7 Hz 4821-4821.7 Hz 4822-4822.7 Hz 4823-4823.7 Hz
    4833-4833.7 Hz 4841-4841.7 Hz 4844-4844.7 Hz 4850-4850.7 Hz
    4866-4866.7 Hz 4870-4870.7 Hz 4874-4874.7 Hz 4890-4890.7 Hz
    4924-4924.7 Hz 4941-4941.7 Hz 4946-4946.7 Hz 4948-4948.7 Hz
    4997-4997.7 Hz 4998-4998.7 Hz 5034-5034.7 Hz 5063-5063.7 Hz
    5089-5089.7 Hz 5116-5116.7 Hz 5139-5139.7 Hz 5142-5142.7 Hz
    5152-5152.7 Hz 5154-5154.7 Hz 5156-5156.7 Hz 5165.4-5166 Hz
    5205-5205.7 Hz 5209-5209.7 Hz 5209.4-5210 Hz 5221-5221.7 Hz
    5229-5229.7 Hz 5232-5232.7 Hz 5239-5239.7 Hz 5243-5243.7 Hz
    5259-5259.7 Hz 5265-5265.7 Hz 5270-5270.7 Hz 5286-5286.7 Hz
    5322-5322.7 Hz 5336-5336.7 Hz 5378.2-5378.7Hz 5407.3-5408 Hz
    5414-5414.7 Hz 5424-5424.7 Hz 5427-5427.7 Hz 5438-5438.7 Hz
    5484.4-5485 Hz 5510-5510.7 Hz 5533-5533.7 Hz 5618-5618.7 Hz
    5640.4-5641 Hz 5671-5671.7 Hz 5714-5714.7 Hz 5716-5716.7 Hz
    5741-5741.7 Hz 5742-5742.7 Hz 5752-5752.7 Hz 5766-5766.7 Hz
    5881-5881.7 Hz 5884-5884.7 Hz 5976-5976.7 Hz 5996-5996.7 Hz
    6010-6010.7 Hz 6024-6024.7 Hz 6058-6058.7 Hz 6070-6070.7 Hz
    6074-6074.7 Hz 6094-6094.7 Hz 6112-6112.7 Hz 6117-6117.7 Hz
    6159-6159.7 Hz 6167-6167.7 Hz 6179-6179.7 Hz 6220.3-6221 Hz
    6252-6252.7 Hz 6297-6297.7 Hz 6298.4-6299 Hz 6317-6317.7 Hz
    6330-6330.7 Hz 6333-6333.7 Hz 6334-6334.7 Hz 6346-6346.7 Hz
    6380.4-6381 Hz 6392-6392.7 Hz 6413-6413.7 Hz 6414-6414.7 Hz
    6416.3-6417 Hz 6419.3-6420 Hz 6423-6423.7 Hz 6432-6432.7 Hz
    6436-6436.7 Hz 6438-6438.7 Hz 6441-6441.7 Hz 6443-6443.7 Hz
    6444-6444.7 Hz 6468-6468.7 Hz 6469-6469.7 Hz 6479.4-6480 Hz
    6488-6488.7 Hz 6492.3-6493 Hz 6513-6513.7 Hz 6537-6537.7 Hz
    6648-6648.7 Hz 6717-6717.7 Hz 6727.4-6728 Hz 6730-6730.7 Hz
    6748-6748.7 Hz 6751-6751.7 Hz 6781-6781.7 Hz 6782-6782.7 Hz
    6808-6808.7 Hz 6809-6809.6 Hz 6825-6825.7 Hz 6832-6832.7 Hz
    6840-6840.7 Hz 6841-6841.7 Hz 6847-6847.7 Hz 6864-6864.7 Hz
    6869-6869.7 Hz 6897-6897.7 Hz 6911.3-6912 Hz 6912-6912.7 Hz
    6914-6914.7 Hz 6968.4-6969 Hz 6974-6974.7 Hz 6982-6982.7 Hz
    6986-6986.7 Hz 7013-7013.7 Hz ' 7037-7037.7 Hz 7042-7042.7 Hz
    7080-7080.7 Hz 7098-7098.7 Hz 7109-7109.7 Hz 7110-7110.7 Hz
    7112-7112.7 Hz 7117-7117.7 Hz 7136-7136.7 Hz 7137-7137.7 Hz
    7145.4-7146 Hz 7149-7149.7 Hz 7151-7151.7 Hz 7158-7158.7 Hz
    7160-7160.7 Hz 7169-7169.7 Hz 7191.7-7192.3Hz 7222.4-7223 Hz
    7225-7225.7 Hz 7234-7234.7 Hz 7239-7239.7 Hz 7246-7246.7 Hz
    7253-7253.7 Hz 7268-7268.7 Hz 7274-7274.7 Hz 7283-7283.7 Hz
    7338-7338.7 Hz 7367-7367.7 Hz 7378-7378.7 Hz 7404.4-7405 Hz
    7424-7424.7 Hz 7440-7440.7 Hz 7481-7481.7 Hz 7510-7510.7 Hz
    7526-7526.6 Hz 7531-7531.7 Hz 7546-7546.7 Hz 7551-7551.7 Hz
    7560-7560.7 Hz 7646-7646.7 Hz 7652-7652.7 Hz 7655-7655.7 Hz
    7673-7673.7 Hz 7676-7676.7 Hz 7719-7719.7 Hz 7748-7748.7 Hz
    7787-7787.7 Hz 7808-7808.7 Hz 7811-7811.7 Hz 7855-7855.7 Hz
    7857-7857.7 Hz 7865-7865.7 Hz 7879-7879.7 Hz 7906-7906.7 Hz
    7910-7910.7 Hz 7913-7913.7 Hz 7923-7923.7 Hz 7927-7927.7 Hz
    7930-7930.7 Hz 7936-7936.7 Hz 7951-7951.7 Hz 7970-7970.7 Hz
    7981-7981.7 Hz 7994-7994.7 Hz 8012.3-8013 Hz 8013-8013.7 Hz
    8024-8024.7 Hz 8026-8026.7 Hz 8032-8032.7 Hz 8039-8039.7 Hz
    8043-8043.7 Hz 8074-8074.7 Hz 8079-8079.7 Hz 8097-8097.7 Hz
    8125-8125.7 Hz 8145-8145.7 Hz 8158-8158.7 Hz 8217.4-8218 Hz
    8251-8251.7 Hz 8314-8314.7 Hz 8332-8332.7 Hz 8347-8347.7 Hz
    8355-8355.7 Hz 8373-8373.7 Hz 8386-8386.7 Hz 8388-8388.7 Hz
    8412-8412.7 Hz 8413-8413.7 Hz 8421-8421.7 Hz 8427-8427.7 Hz
    8445-8445.7 Hz 8447-8447.7 Hz 8467-8467.7 Hz 8478.3-8479 Hz
    8480-8480.7 Hz 8484-8484.7 Hz 8509.4-8510 Hz 8522-8522.7 Hz
    8546-8546.7 Hz 8562-8562.7 Hz 8576-8576.7 Hz 8698-8698.7 Hz
    8731-8731.7 Hz 8734-8734.7 Hz 8740-8740.7 Hz 8755-8755.7 Hz
    8756-8756.7 Hz 8757-8757.7 Hz 8765-8765.7 Hz 8771-8771.7 Hz
    8789.3-8790 Hz 8809-8809.7 Hz 8810-8810.7 Hz 8814-8814.7 Hz
    8823-8823.7 Hz 8824-8824.7 Hz 8827.4-8828 Hz 8829-8829.7 Hz
    8837-8837.7 Hz 8841-8841.7 Hz 8843-8843.7 Hz 8845-8845.7 Hz
    8846-8846.7 Hz 8853-8853.7 Hz 8859.3-8860 Hz 8872-8872.7 Hz
    8877-8877.7 Hz 8881-8881.7 Hz 8889-8889.7 Hz 8926-8926.7 Hz
    8935-8935.6 Hz 8949-8949.7 Hz 9023-9023.7 Hz 9071-9071.7 Hz
    9075-9075.7 Hz 9078-9078.7 Hz 9084-9084.7 Hz 9106-9106.7 Hz
    9109-9109.7 Hz 9112-9112.7 Hz 9122-9122.7 Hz 9123-9123.7 Hz
    9133-9133.7 Hz 9136-9136.7 Hz 9146-9146.7 Hz 9155.7-9156.2Hz
    9157-9157.7 Hz 9161-9161.7 Hz 9169-9169.7 Hz 9174-9174.7 Hz
    9179-9179.7 Hz 9194-9194.7 Hz 9230-9230.7 Hz 9236-9236.7 Hz
    9247-9247.7 Hz 9273-9273.7 Hz 9506-9506.7 Hz 9512-9512.7 Hz
    9573-9573.7 Hz 9588-9588.7 Hz 9635-9635.7 Hz 9656-9656.7 Hz
    9681-9681.7 Hz 9695-9695.7 Hz 9731-9731.7 Hz 9846-9846.7 Hz___
    9851-9851.7 Hz 9886-9886.7 Hz 9921-9921.7 Hz 9929-9929.7 Hz
    9935-9935.7 Hz 9947-9947.7 Hz 9961-9961.7 Hz 9970-9970.7 Hz
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    94494-94494.7 Hz 94968.3-94969 Hz 95245-95245.7 Hz 95742-95742.7 Hz
    99281-99281.7 Hz 99846-99846.7 Hz ____ __—-----
  2. 2. The apparatus of claim 1, wherein the cancer is selected from the group consisting of: breast cancer, neuroendocrine tumors, non-Hodgkin lymphoma, adenocarcinoma, head and neck cancer, gastric cancer, glioblasloma, squamous cell carcinoma, hepatocellular carcinoma, cholangiocarcinoma, mesothelioma, thyroid cancer, prostate cancer, rhabdomyosarcoma, iung cancer, kidney cancer, ovarîan cancer, bladder cancer, leiomyosarcoma, myeloma, lymphoma, leukemia, chronic lymphoid cancer, brain cancer, and colorectal cancer.
  3. 3. The apparatus of claim 1 or 2, wherein the carrier frequency is from about 0.1 - 1000
    MHz, or from about 1-500 MHz, or from about 1-100 MHz, or from about 5-50 MHz, or from about 10 MHz to about 40 MHz, or from about 15 MHz to about 30 MHz.
  4. 4. The apparatus according to any one of daims 1 to 3, wherein the frequency synthesizer is a digital frequency synthesizer comprising:
    a digital carrier frequency synthesizer configured to output the carrier frequency signal;
    a digital modulation frequency synthesizer configured to output the one or more amplitude modulation frequency signais; and an arithmetic logic unit (ALU) configured to numerîcally compute one or more digital modulated signais from the carrier frequency signal and a modulation frequency digital signal in real-time; and a digital to analog converter (DAC) configured to couvert the one or more digital modulated signais to the one or more amplitude-modulated output signais.
  5. 5. An apparatus for treating a subject suffering from cancer, the apparatus comprising:
    a conductive applicator configured to apply to the subject low energy high frequency radiation, wherein the low energy high frequency radiation comprises one or more amplitudemodulated output signais; and a frequency synthesizer coupled to the conductive applicator and configured to generate the one or more amplitude-modulated output signais by generating:
    a carrier frequency signal having a carrier frequency from about IKHz to 5000 MHz; and amplitude modulation frequency signais having amplitude modulation frequencies from about 0.1 Hz to about 150,000 Hz, wherein the amplitude modulation frequencies are selected to be cancer-specific frequencies;
    wherein the frequency synthesizer is a digital frequency synthesizer comprising.
    a digital carrier frequency synthesizer configured to output the carrier frequency signal;
    a digital modulation frequency synthesizer configured to output the one or more amplitude modulation frequency signais;
    an arithmetic logic unit (ALU) configured to numerically compote one or more digital moduiated signais from the carrier frequency signal and a modulation frequency digital signal in real-tîme; and a digital to analog converter (DAC) configured to couvert the one or more 5 digital moduiated signais to the one or more amplitude-modulated output signais.
  6. 6. The apparatus of claim 5, wherein the cancer is selected from the group consisting of: breast cancer, neuroendocrine tumors, non-Hodgkin lymphoma, adenocarcînoma, head and neck cancer, gastric cancer, glioblastoma, squamous cell carcinoma, hepatocellular carcinoma, 10 cholangiocarcinoma, mesothelioma, thyroid cancer, prostate cancer, rhabdomyosarcoma, lung cancer, kidney cancer, ovarian cancer, bladder cancer, leiomyosarcoma, myeloma, lymphoma, leukemia, chronic lymphoid cancer, brain cancer, and colorectal cancer.
  7. 7. The apparatus of claim 5 or 6, wherein the carrier frequency is from about 0.1 - 1000 15 MHz, or from about 1-500 MHz, or from about 1-100 MHz, or from about 5-50 MHz, or from about 10 MHz to about 40 MHz, or from about 15 MHz to about 30 MHz.
  8. 8. The apparatus according to any one of daims 5 to 7, wherein the modulation frequency îs from 100 Hz to 99,000 Hz.
  9. 9. The apparatus according to any one of daims 5 to 8, wherein the digital frequency synthesizer further comprises a controller configured to control a frequency and a power associated with the one or more amplitude-modulated output signais.
    25
  10. 10. The apparatus according to any one of daims 5 to 9, further comprising a directional coupler for providing, to the controller, power and absorption information relatîng to each of the one or more amplitude-modulated output signais.
  11. 11. The apparatus according to any one of daims 5 to 310 wherein the digital frequency 30 synthesizer further comprises a phase-locked loop (PLL) frequency multiplier configured to set a System dock for one or more of the following: the digital carrier frequency synthesizer or the digital modulation frequency synthesizer.
  12. 12. The apparatus according to any one of daims 5 to 11, wherein the digital carrier frequency synthesizer is a direct digital synthesizer (DDS).
  13. 13. The apparatus according to any one of daims 5 to 11, wherein the digital modulation 5 frequency synthesizer îs a direct digital synthesizer (DDS).
  14. 14. The apparatus according to any one of daims 1 to 13, wherein the frequency synthesizer is configured to generate the one or more amplitude-modulated output signais, either sequentially or simultaneously.
  15. 15. The apparatus according to any one of daims 1 to 14, wherein the conductive applicator is configured for insertion into an oral cavity of the subject undergoing treatment.
  16. 16. The apparatus according to any one of daims 1 to 15, wherein the amplitude modulation 15 frequencies are determined or predetermined by a bio-feedback process involving observations or measurements of physiological reactions by the subject during a time that cellular fonctions of the subject are excited by exposing the subject to émission of a modulated output signal.
OA1202200158 2019-10-21 2020-10-20 Electrical system for treatment of a subject OA20699A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62/923,908 2019-10-21
US62/934,212 2019-11-12

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Publication Number Publication Date
OA20699A true OA20699A (en) 2022-12-30

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