OA20645A - Stable herbicide formulation of Pyrazosulfuron ethyl. - Google Patents
Stable herbicide formulation of Pyrazosulfuron ethyl. Download PDFInfo
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- OA20645A OA20645A OA1202100386 OA20645A OA 20645 A OA20645 A OA 20645A OA 1202100386 OA1202100386 OA 1202100386 OA 20645 A OA20645 A OA 20645A
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- OA
- OAPI
- Prior art keywords
- composition
- pyrazosulfuron ethyl
- silica
- china clay
- pyrazosulfuron
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 95
- BGNQYGRXEXDAIQ-UHFFFAOYSA-N Pyrazosulfuron-ethyl Chemical group C1=NN(C)C(S(=O)(=O)NC(=O)NC=2N=C(OC)C=C(OC)N=2)=C1C(=O)OCC BGNQYGRXEXDAIQ-UHFFFAOYSA-N 0.000 title claims abstract description 66
- 238000009472 formulation Methods 0.000 title abstract description 8
- 230000002363 herbicidal Effects 0.000 title abstract description 6
- 239000004009 herbicide Substances 0.000 title abstract description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 53
- 239000004927 clay Substances 0.000 claims description 38
- 229910052570 clay Inorganic materials 0.000 claims description 38
- 230000003019 stabilising Effects 0.000 claims description 34
- 239000000377 silicon dioxide Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 17
- 238000002156 mixing Methods 0.000 claims description 13
- BPQQTUXANYXVAA-UHFFFAOYSA-N silicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims description 11
- 241000196324 Embryophyta Species 0.000 claims description 10
- 239000003905 agrochemical Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 238000003801 milling Methods 0.000 claims description 6
- VXMNDQDDWDDKOQ-UHFFFAOYSA-N Pyrazosulfuron Chemical compound COC1=CC(OC)=NC(NC(=O)NS(=O)(=O)C=2N(N=CC=2C(O)=O)C)=N1 VXMNDQDDWDDKOQ-UHFFFAOYSA-N 0.000 claims description 3
- 229910021485 fumed silica Inorganic materials 0.000 claims description 3
- 230000000087 stabilizing Effects 0.000 abstract description 4
- -1 dimethoxypyrimidin-2-ylcarbamoyl Chemical group 0.000 description 26
- 229920000056 polyoxyethylene ether Polymers 0.000 description 24
- 229940051841 POLYOXYETHYLENE ETHER Drugs 0.000 description 22
- 239000011734 sodium Substances 0.000 description 17
- 229910052708 sodium Inorganic materials 0.000 description 17
- 150000002191 fatty alcohols Chemical class 0.000 description 10
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 10
- 239000004094 surface-active agent Substances 0.000 description 10
- LSNNMFCWUKXFEE-UHFFFAOYSA-L Sulphite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- 229920001732 Lignosulfonate Polymers 0.000 description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 6
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical class C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 description 6
- 239000010452 phosphate Substances 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 5
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 5
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 5
- KUXGUCNZFCVULO-UHFFFAOYSA-N 2-(4-nonylphenoxy)ethanol Chemical compound CCCCCCCCCC1=CC=C(OCCO)C=C1 KUXGUCNZFCVULO-UHFFFAOYSA-N 0.000 description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 229920001400 block copolymer Polymers 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- HCWYXKWQOMTBKY-UHFFFAOYSA-N calcium;dodecyl benzenesulfonate Chemical compound [Ca].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 HCWYXKWQOMTBKY-UHFFFAOYSA-N 0.000 description 4
- 239000002270 dispersing agent Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229920000847 nonoxynol Polymers 0.000 description 4
- 229920000570 polyether Polymers 0.000 description 4
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 description 4
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000000080 wetting agent Substances 0.000 description 4
- PZZYQPZGQPZBDN-UHFFFAOYSA-N Aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2R)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 229920005552 sodium lignosulfonate Polymers 0.000 description 3
- DUIOKRXOKLLURE-UHFFFAOYSA-N 2-octylphenol Chemical compound CCCCCCCCC1=CC=CC=C1O DUIOKRXOKLLURE-UHFFFAOYSA-N 0.000 description 2
- 229940045714 Alkyl sulfonate alkylating agents Drugs 0.000 description 2
- 229960005069 Calcium Drugs 0.000 description 2
- 229960003563 Calcium Carbonate Drugs 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 241000722731 Carex Species 0.000 description 2
- RZXLPPRPEOUENN-UHFFFAOYSA-N Chlorfenson Chemical compound C1=CC(Cl)=CC=C1OS(=O)(=O)C1=CC=C(Cl)C=C1 RZXLPPRPEOUENN-UHFFFAOYSA-N 0.000 description 2
- 239000005909 Kieselgur Substances 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Natural products C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- SNQQPOLDUKLAAF-UHFFFAOYSA-N Nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 2
- 241000209094 Oryza Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 229920002675 Polyoxyl Polymers 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- HWKQNAWCHQMZHK-UHFFFAOYSA-N Trolnitrate Chemical compound [O-][N+](=O)OCCN(CCO[N+]([O-])=O)CCO[N+]([O-])=O HWKQNAWCHQMZHK-UHFFFAOYSA-N 0.000 description 2
- WWBXZKQQXUFSED-UHFFFAOYSA-N [Na].O=C.C1=CC=C2C(S(=O)(=O)OC)=CC=CC2=C1 Chemical compound [Na].O=C.C1=CC=C2C(S(=O)(=O)OC)=CC=CC2=C1 WWBXZKQQXUFSED-UHFFFAOYSA-N 0.000 description 2
- 150000003973 alkyl amines Chemical class 0.000 description 2
- 150000008051 alkyl sulfates Chemical class 0.000 description 2
- 150000008052 alkyl sulfonates Chemical class 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000006229 carbon black Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N diguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000002193 fatty amides Chemical class 0.000 description 2
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 229910003480 inorganic solid Inorganic materials 0.000 description 2
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 description 2
- 229920005610 lignin Polymers 0.000 description 2
- HOPIDIRJCBJLSF-UHFFFAOYSA-N methyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(=O)OC)=CC=CC2=C1 HOPIDIRJCBJLSF-UHFFFAOYSA-N 0.000 description 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 2
- 229920005646 polycarboxylate Polymers 0.000 description 2
- 229910052903 pyrophyllite Inorganic materials 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- ASEFUFIKYOCPIJ-UHFFFAOYSA-M sodium;2-dodecoxyethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOS([O-])(=O)=O ASEFUFIKYOCPIJ-UHFFFAOYSA-M 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- QYKIQEUNHZKYBP-UHFFFAOYSA-N vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000000593 degrading Effects 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- HGWNQLBXGHYTMN-UHFFFAOYSA-N pyrimidin-2-ylsulfonylurea Chemical compound NC(=O)NS(=O)(=O)C1=NC=CC=N1 HGWNQLBXGHYTMN-UHFFFAOYSA-N 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N tin hydride Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Abstract
The present invention provides a stabilizing system for preparing stable herbicide formulation comprising pyrazosulfuron ethyl.
Description
7 STABLE HERBICIDE FORMULATION OF PYRAZOSULFURON ETHYL
FIELD OF INVENTION
The présent invention relates to a stable herbicide formulation comprising pyrazosulfuron ethyl. The présent invention also relates to a stabilising System for formulation comprising pyrazosulfuron ethyl and method of préparation the formulation.
BACKGROUND OF THE INVENTION
Pyrazosulfuron ethyl is a pyrimidinylsulfonylurea herbicide having IUPAC name 5-[(4,6 5 dimethoxypyrimidin-2-ylcarbamoyl) sulfamoyl]-l-methyl pyrazole-4-carboxylic acid and
Chemical structure as follows:
Pyrazosulfuron ethylis a systemic herbicide used to control annual and perennial broad-leaved weeds and sedges, pre- or post-emergence, wet sown and transplanted rice crops.
Varions agrochemical compositions comprising pyrazosulfuron ethyl as active ingrédient are available in the market, but they are known to be degrading during the shelf life of the product. The dégradation of the active ingrédient is not suitable for formulation and will resuit in ineffective dose application when applied in the field thus resulting in poor control of weeds.
Hence, there is an urgent and unmet need of the stable formulation comprising pyrazosulfuron ethyl which is stable prevent dégradation during its shelf life.
OBJECT OF THE INVENTION
It is an object of the présent invention to provide a storage stable composition comprising pyrazosulfuron ethyl.
It is another object of the présent invention to provide a process for preparing a storage stable composition comprising pyrazosulfuron ethyl.
It is an object of the présent invention to to provide a stable composition comprising pyrazosulfuron ethyl that does not undergo dégradation.
SUMMARY OF INVENTION
In an aspect the présent invention provides a storage stable agrochemical composition comprising:
a) pyrazosulfuron ethyl; and
b) astabilising System comprising silicaand china clay
In another aspect the présent invention provides a process for préparation of storage stable 5 composition comprising herbicidally effective amount of pyrazosulfuron ethyl and a stabilising System comprising silica and china clay, said process comprising:
Step-1: Pre-blending of pyrazosulfuron ethyl and stabilising System comprising silica and china clay optionally with agrochemically acceptable excipients;
Step-2: Milling; and
Step-3: Post-blendîng and/or drying to get a compositionwith predefined % moisture.
In another aspect the présent invention provides a method of controlling undesired weeds, 10 said method comprising applying to the weeds or to their locus an herbicidally effective amount of astorage stable agrochemical composition according to the présent invention.
DETAILED DESCRIPTION OF THE INVENTION
The présent invention provides an agrochemical composition and in particular a storage stable agrochemical composition.
It is surprising to found that a stabilising System comprising silica and china clay, helps to increase shelf life of the product comprising pyrazosulfuron ethyl of formula-1.
Formua-1:
pCH3 :O2CH2CH3 <-SGaNHCONH-^ ?
ch3
OCHS
Surprisingly the présent inventors found a stabilizing System which is effective in increasing stability and shelf life of agrochemical compositions comprising pyrazosulfuron ethyl.
Tn an embodiment there is provided a storage stable composition comprising:
a) pyrazosulfuron ethyl; and
b) astabilising System comprising silicaand china clay.
Tn another embodiment the storage stable compositions according to the présent invention further comprises other agrochemically acceptable surfactants.
Thus, in an embodiment there is provided a storage stable composition comprising:
a) pyrazosulfuron ethyl;
b) astabilising System comprising silicaand china clay; and
c) optionally an agrochemically acceptable surfactant.
Tn an embodiment storage stable composition comprises pyrazosulfuron ethyl as anactive ingrédient.
In another embodiment storage stable composition comprises herbicidally effective amount of pyrazosulfuron ethyl as active ingrédient.
In another embodiment storage stable composition according to the présent invention comprisespyrazosulfuron ethyl in the concertation of from about 0.1% to about 25%.
In another embodiment storage stable composition comprises herbicidally effective amount of pyrazosulfuron ethyl in combination with other agrochemically active ingrédient.
In another embodiment, according to the présent invention, dégradation of pyrazosulfuron ethyl is controlled.
In another embodiment, according to the présent invention, dégradation of pyrazosulfuron ethyl is controlled to <5% of pyrazosulfuron ethyl présent in the composition.
In an embodiment storage stable composition of pyrazosulfuron ethyl according to the présent invention comprises a stabilising System.
Tn another embodiment stabilising System of storage stable composition of pyrazosulfuron ethyl according to the présent invention comprisessilica and china clay.
In another embodiment,stabilising System of storage stable composition of pyrazosulfuron ethyl comprises silica selected from precipitated silica and fumed silica.
In another embodiment stabilising System of storage stable composition of pyrazosulfuron ethyl comprises silica in the concertation of from about 0.1% to about 10%.
]q in another embodiment stabilising System of storage stable composition of pyrazosulfuron ethyl comprises silica in the concertation of from about 0.1% to about 7%.
In another embodiment stabilising System of storage stable composition of pyrazosulfuron ethyl comprises china clay.
In an embodiment china clay of stabilising System has water holding capacity of up to 75% by weight.
In another embodiment stabilising System of storage stable composition of pyrazosulfuron ethyl comprises china clay in the concertation of 10% to 90%.
In another embodiment stabilising System of storage stable composition of pyrazosulfuron ethyl comprises precipitated silica and china clay, in a ratio from aboutl:5 to about 1:30.
In another embodiment stabilising System of storage stable composition of pyrazosulfuron ethyl comprises precipitated silica and china clay, in a ratio from about 1:7 to about 1:20.
.
In an embodiment, the storage stable composition of pyrazosulfuron ethyl according to the présent invention comprises an agrochemically acceptable surfactant.
Thus, in an embodiment, there is provided a storage stable composition comprising:
a) pyrazosulfuron ethyl;
b) astabilising System comprising silica and china clay; and
c) an agrochemically acceptable surfactant.
In an embodiment, the stabilising System of storage stable composition of pyrazosulfuron 5 ethyl comprises silica selected from precipitated silica and fumed silica.
In another embodiment stabilising System of storage stable composition of pyrazosulfuron ethyl comprises silica in the concertation of from about 0.1 % to about 10%.
In another embodiment stabilising System of storage stable composition of pyrazosulfuron ethyl comprises silica in the concertation of from about 1% to about 7%.
In another embodiment stabilising System of storage stable composition of pyrazosulfuron ethyl comprises china clay.
In another embodiment stabilising System of storage stable composition of pyrazosulfuron ethyl comprises china clay in the concertation of from about 10% to about 90%.
In another embodiment stabilising System of storage stable composition of pyrazosulfuron ethyl comprises china clay in the concertation of from about 50% to about 90%.
U In another embodiment stabilising System of storage stable composition of pyrazosulfuron ethyl comprises china clay in the concertation of from about 60% to about 80%.
In an embodiment of the présent invention, agrochemically acceptable surfactant may be selected from dispersing agents, wetting agents, fillers and the like.
In stated embodiment, agrochemically accepted excipients may be selected from, but not limited to, following stated agrochemically accepted excipients:
Dispersing agents may include lignosulfonate, calcium lignin iodate, sodium lauryl polyoxyethylene ether sulfate, alkyl naphthalene condensate sulfonate, sodium dodecyl benzene sulfonate, sodium lauryl sulfate, Alkyl polyoxyethylene ether sulfonate, alkylphenol polyoxyethylene ether formaldéhyde condensate, alkylphenol polyoxyethylene ether nonylphenol polyoxyethylene ether, polyoxyethylene polyoxypropylene ether block copolymer , pull-open powder, high molecular carboxylate, sodium methylene biguanide sulfonate, polyvinyl alcohol, modified naphthalene sulfonate, polycarboxylate, alkylnaphthalene sulfonate, alkylphenol polyoxyl Vinyl ether, EO/PO block polyether, JFC, unrolled powder, nonylphenol ethoxylate, octylphenol polyoxyethylene sulfate, fatty alcohol sulfate, alkylnaphthalene sulfonate, fatty amide N- Methanesulfonate, fatty alcohol sodium polyoxyethylene sulfate, fatty acid sulfate, fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, alkylbenzyldimethylammonium chloride, alkylamine oxide, etc. or mixture thereof.
Wetting agents may include alkyl sulfates, alkyl sulfonates, naphthalene sulfonates, sodium lignosulfonate, fatty alcohol polyoxyethylene ethers, alkylphenol ethoxylates, short chain EO/PO block polyethers, nonylphenol ethoxylate, nonionic ethoxylate, sodium alkyl sulfate, sodium dodecyl sulfate, TERSPERSE 2700, TERSPERSE 1004, sodium lignosulfonate, NNO, polyoxyethylene polyoxypropylene one or a combination of two or more of an ether block copolymer, an alkylphenol polyoxyethylene ether phosphate, or a water-soluble polymer compound CMC or PVA, etc. or mixtures thereof
Fillers may includean organic or inorganic solid inert substance such as talc, clay, diatomaceous earth, magnésium aluminum silicate, white carbon black, pyrophyllite, light calcium carbonate, high clay, organic bentonite, etc. or mixtures thereof.
Surfactants may include sodium dodecylbenzenesulfonate, calcium dodecylbenzenesulfonate, sodium alkyl sulfate, fatty alcohol sulfate, alkyl ethylsulfonate, Sodium methylnaphthalene sulfonate formaldéhyde condensate, naphthalene sulfonate, formaldéhyde condensate, polycarboxylic acid, lignosulfonate, alkylphenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether or a variety, etc. or mixtures thereof.
In another embodiment the surfactant is selected from sodium alkyl sulfate, formaldéhyde condensâtes, sodium dodecylbenzenesulfonate, calcium dodecylbenzenesulfonate, fatty 7 alcohol sulfate, alkyl ethylsulfonat, Sodium methylnaphthalene sulfonate, naphthalene sulfonate formaldéhyde condensate, polycarboxylic acid, lignosulfonate, alkylphenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether, etc. or mixtures thereof.
In another embodiment there is provided a process for préparation of storage stable composition comprising herbicidally effective amount of pyrazosulfuron ethyl and astabilismg system comprising silica and china clay.
Tn an embodiment the composition is formulated as a solid composition.
In a preferred embodiment the composition is formulated as powder (WP).
llnan embodiment there is provided a process for préparation of storage stable composition comprising herbicidally effective amount of pyrazosulfuron ethyl and a stabilising System comprising silica and china clay, said process comprising:
Step-1: Pre-blending of pyrazosulfuron ethyl and stabilising System comprising silica and china clayoptionally with agrochemically acceptable excipients;
Step-2: Milling; and
Step-3: Post-blending and/or drying to get a composition with predefined % moisture.
In another embodiment there is provided a process for préparation of storage stable composition comprising herbicidally effective amount of pyrazosulfuron ethyl and a stabilising System comprising silica and china clay, said process comprising:
Step-1: Pre-blending of pyrazosulfuron ethyl and stabilising system comprising silica and china clay optionally with agrochemically acceptable excipients;
Step-2: Milling;
Step-3: Post-blending and/or drying to get a composition with predefined % moisture; and
Step-4: Formulating to a suitable form using a suitable equipment
In above stated embodiment, in step-1, the terni ‘stabilising System’ refers to stabilising System comprising silica and china clay, in stabilizing effective ratio.
In above stated embodiment, in step-1, the tenu ‘agrochemically accepted excipients’ refers 5 to additives of the composition that may be selected from dispersing agents, wetting agents, fillers, surfactants, etc.
In above stated embodiment, in step-1, agrochemically accepted excipients may be selected from, but not limited to, foliowing stated agrochemically accepted excipients:
Dispersing agents may include lignosulfonate, calcium lignin iodate, sodium lauryl polyoxyethylene ether sulfate, alkyl naphthalene condensate sulfonate, sodium dodecyl 10 benzene sulfonate, sodium lauryl sulfate, Alkyl polyoxyethylene ether sulfonate, alkylphenol polyoxyethylene ether formaldéhyde condensate, alkylphenol polyoxyethylene ether nonylphenol polyoxyethylene ether, polyoxyethylene polyoxypropylene ether block copolymer , pull-open powder, high molecular carboxylate, sodium methylene biguanide sulfonate, polyvinyl alcohol, modified naphthalene sulfonate, polycarboxylate, alkylnaphthalene sulfonate, alkylphenol polyoxyl Vinyl ether, EO/PO block polyether, JFC, 15 unrolled powder, nonylphenol ethoxylate, octylphenol polyoxyethylene sulfate, fatty alcohol sulfate, alkylnaphthalene sulfonate, fatty amide N- Methanesulfonate, fatty alcohol sodium polyoxyethylene sulfate, fatty acid sulfate, fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, alkylbenzyldimethylammonium chloride, alkylamine oxide, etc. or mixture thereof.
Wetting agents may include alkyl sulfates, alkyl sulfonates, naphthalene sulfonates, sodium 20 lignosulfonate, fatty alcohol polyoxyethylene ethers, alkylphenol ethoxylates, short chain EO/PO block polyethers, nonylphenol ethoxylate, nonionic ethoxylate, sodium alkyl sulfate, sodium dodecyl sulfate, TERSPERSE 2700, TERSPERSE 1004, sodium lignosulfonate, NNO, polyoxyethylene polyoxypropylene one or a combination of two or more of an ether block copolymer, an alkylphenol polyoxyethylene ether phosphate, or a water-soluble polymer compound CMC or PVA, etc. or mixtures thereof.
Piliers may include an organic or inorganic solid inert substance such as talc, clay, diatomaceous earth, magnésium aluminum silicate, white carbon black, pyrophyllite, light calcium carbonate, high clay, organic bentonite, etc. or mixtures thereof.
Surfactants may include sodium dodecylbenzenesulfonate, calcium dodecylbenzenesulfonate, 5 sodium alkyl sulfate, fatty alcohol sulfate, alkyl ethylsulfonate, Sodium methylnaphthalene sulfonate formaldéhyde condensate, naphthalene sulfonate, formaldéhyde condensate, polycarboxylic acid, lignosulfonate, alkylphenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether or a variety, etc. or mixtures thereof.
In another embodiment the surfactant is selected from sodium alkyl sulfate, formaldéhyde 0 condensâtes, sodium dodecylbenzenesulfonate, calcium dodecylbenzenesulfonate, fatty alcohol sulfate, alkyl ethylsulfonat, Sodium methylnaphthalene sulfonate, naphthalene sulfonate formaldéhyde condensate, polycarboxylic acid, lignosulfonate, alkylphenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether, etc. or mixtures thereof.
In yet. another embodiment, in step-1, pre-blending is camed out in a time period of about 15 15 minutes to 2 hours by charging pyrazosulfuron ethyl,stabilising System comprising precipitated silica and china clay and agrochemically accepted excipients if any simultaneously.
In anembodiment, step-2 provides a process for milling of pre-blended mixture of Step-1.
In another embodiment, Step-2 comprises grinding of the pre-blended mixture of Step-1 at pressure 6 to 8 Kg / cm2to obtain ground material with spécifie particle size.
In the présent invention, the tenu ‘spécifie particle size’ refers to D90 - less than 15 micron and/or wet sieve - 99.8 % passing through 500 BSS test.
In another embodiment, step-3 provides a process for post-blending of ground pyrazosulfuron ethyl, stabilising System and agrochemically accepted excipients if any, obtained as product of step-2.
Ί ...
In another embodiment, step-3 comprises blending of ground pyrazosulfuron ethyl, stabilising
System, and agrochemically accepted excipients if any, obtained as product of step-2 for a time period of about 15 min to 2 hours in order to facilitate complété homogénisation of resulting powder composition.
In another embodiment, step-3 comprises drying of the blended mixture to get a product with predefined % moisture.
Tn another embodiment, step-3 comprises drying of the blended mixture to get a product with % moisture <2%.
Tn a preferred embodiment, step-3 comprises drying of the blended mixture to get a product with % moisture <1%.
Tn another embodiment, in step-4, the process of formulating is not particularly limiting.
In a preferred embodiment tin step-4 the composition according to the présent invention is formulated in the form of powder.
The présent invention provides a method of controlling undesired weeds, said method 10 comprising applying to the weeds or to their locus an herbicidally effective amount of a storage stable agrochemical composition comprising:
a) Pyrazosulfuron ethyl; and
b) astabilising System comprising silica and china clay.
In an embodiment, the présent invention provides a method controlling annual and perennial broad-leaved weeds and sedges, pre- or post-emergence, in wet-sown and transplanted rice crops, said method comprising applying to the weeds or to their locus an herbicidally effective amount of a storage stable agrochemical composition comprising:
a) Pyrazosulfuron ethyl; and
b) a stabilising System comprising silica and china clay.
The invention will now be described further by reference to the following examples, which are intended to illustrate, but not limit, the scope of the appended claims.
Example 1
Exemplary composition was prepared as follows:
| Sr.no | Ingrédients | Quantity (w/w) |
| 1 | Pyrazosulfuron ethyl | 10.9 |
| 2 | Precipitated Silica | 4.00 |
| 3 | China Clay | 78.1 |
| 4 | Sodium alkyl sulphate | 3.00 |
| 5 | Formaldéhyde condensate | 4.00 |
Process conditions:
Step-1 (Pre-Blending): Pyrazosulfuron ethyl, precipitated Silica,china Clay, sodium alkyl sulphate and formaldéhyde condensate were charged in required quantities in pre-blender. Blending was carried out for 20 Minutes.
Step-2 (Milling): The pre-blended material was ground to desired particle size under grinding pressure
Step-3 (Post-Blending): The ground material was blended in post blender for 15 min to achieve complété homogenization and dried to get the product having a moisture content <1%.
The stability results of the exemplary composition prepared according to above formula are:
| Sr. No | Parameters | AMB | AHS 14 Days | AHS 28 Days |
| 1 | Assay of pyrazosulfuron ethyl (% w/w) | 10.77 | 10.63 | 10.55 |
| 2 | Suspensibility (% w/w) | 94.40 | 89.10 | 95.00 |
| 3 | pH (1% Aq.) | 5.35 | 5.55 | 5.58 |
| 4 | Wet Sieve Test* | 100 | 100 | 100 |
| 5 | Wettability (s) | 15 | 15 | 15 |
| 6 | Moisture Content | 0.64 | 153 | 151 |
| 7 | Bulk Density | 0.256 | NA | NA |
*(material passing through 75-micron test Sieve) (% w/w) % Degradationofpyrazosulfuron ethyl:
| Sample | AMB(Odays) | AHS 14 Days | AHS 28 Days |
| Example 1 | 0.00 | 1.30 | 2.04 |
Compositions according to the présent invention are listed in the below table (Example 2 and 3)
| Sr.no | Ingrédients | Example 2 | Example 3 |
| 1 | Pyrazosulfuron-ethyl | 5.3 | 15 |
| 2 | Precipitated Silica | 4.27 | 3.8 |
| 3 | Formaldéhyde condensate | 4 | 4 |
| 4 | Sodium alkyl sulphate | 3 | 3 |
| 5 | China Clay | 83.43 | 74.2 |
| Total | 100 | 100 |
% Dégradation of pyrazosulfuron ethyl:
| Sample | AMB (Odays) | AHS 14 Days |
| Example 2 | 0.0 | 3.4 |
| Example 3 | 0.0 | 4.1 |
Comparative example (Example 4): A comparative composition of pyrazosulfuron ethyl was prepared as foliows:
| Sr. no | Ingrédients | Quantity (w/w) |
| 1 | Pyrazo sulfuron-ethyl | 10.9 |
| 2 | arylsulfonic acid sodium sait | 04.00 |
| 3 | Anionic surfactant | 04.00 |
| 4 | Sodium Ligno sulphate | 04.00 |
| 5 | Pentab UF | 01.00 |
| 6 | Precipitated Silica | 14.70 |
| 10 | Kaolin | 61.40 |
% Dégradation of pyrazosulfuron ethyl:
| Sample | AMB (0 days) | AHS 14 Days | AHS 28 Days |
| Example 4 | 0.0 | 12.69 | 24.87 |
Exatnple 1-3 demonstrates inventions according to the présent invention. Example 4 is a comparative example in which stabilizing System according to the invention is absent. Zéro timedata was generated for ail the samples. Studied were conducted by keeping the samples at 54°C for 14 days and 28 days. The results indicate that the stabilization System according to the présent invention provides significant Chemical stability to pyrazosulfuron ethyl in the composition.
Claims (11)
1. A s tarage stable agrochemical composition comprising:
a) pyrazosulfuron ethyl; and
b) astabilising System comprising silicaand china clay
2. A composition according to claim 1 wherein said pyrazosulfuron ethylis présent in an amount from about 0.1% to about 25%by weight of the composition
3. A composition according to claim 1 wherein said silica is selected from precipitated silica and fumed silica
4. A composition according to claim 1 wherein said silica ispresent in an amount from about 0.1% to about 10% by weight of the composition.
5. A composition according to claim 1 wherein said china clay is présent in an amount from about 10% to about 90% by weight of the composition.
6. A composition according to claim 1 wherein ratio of said precipitated silica and china clay varies from about 1:5 to about 1:30.
7. A composition according to claim 1 wherein dégradation of pyrazosulfuron ethyl is controlled to <5% of pyrazosulfuron ethyl présent in the composition
8. A process for préparation of storage stable composition comprising herbicidally effective amount of pyrazosulfuron ethyl and a stabilising System comprising silica and china clay, said process comprising:
Step-1: Pre-blending of pyrazosulfuron ethyl and stabilising system comprising silica and china clay optionally with agrochemically acceptable excipients;
Step-2: Milling;
Step-3: Post-blending and/or drying to get a composition with predefined % moisture; and
Step-4: Formulating to a suitable form using a suitable equipment
9. A process of claim 8 wherein said process provides said composition having a % moisture <2%.
10. A process of claim 8 wherein said process provides said composition in the form of powder.
11. A method of controlling undesired weeds, said method comprising applying to the weeds or to their locus an herbicidally effective amount of a storage stable agrochemical composition comprising:
a) Pyrazosulfuron ethyl; and
b) a stabilising System comprising silica and china clay.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201921012064 | 2019-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA20645A true OA20645A (en) | 2022-12-28 |
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