OA20202A - Method for administering hypnotic/sedative agent. - Google Patents

Method for administering hypnotic/sedative agent. Download PDF

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Publication number
OA20202A
OA20202A OA1201500067 OA20202A OA 20202 A OA20202 A OA 20202A OA 1201500067 OA1201500067 OA 1201500067 OA 20202 A OA20202 A OA 20202A
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OA
OAPI
Prior art keywords
patient
anesthésia
general
treatment
needs
Prior art date
Application number
OA1201500067
Inventor
Shigehito Sato
Matsuyuki Doi
Toshihiko KONOMI
Maki Kondo
Original Assignee
Paion Uk Limited
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Publication of OA20202A publication Critical patent/OA20202A/en

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Abstract

By intravenously administering a sedative comprising methyl

Description

[Désignation of Document] SPECIFICATION
[Title of the Invention] DOSING REGIMEN OF SEDATIVE
[Technical Field] [0001]
The présent invention relates to a dosing regimen of a sédative comprising, as an active ingrédient, methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate, which is a benzodiazépine compound, or a sait thereof. More particularly, the invention relates to a dosing regimen of the sédative most suitable for the induction and/or maintenance of general anesthésia.
[Background Art] [0002]
General anesthésia is widely used for the purpose of eliminating physical and mental pain of a patient caused by surgery. Requirements necessary for general anesthésia are as follows: to cause loss of consciousness in a patient (sédation); to eliminate pain (analgesia); to cause loss of body motor (muscle relaxation); and to get rid of unwanted reflexes such as throat seizure and arrhythmia (reflex inhibition) . However, it is difficult to satisfy ail of the requirements using a single anesthetic. Further, the degree of necessity of the requirements for general anesthésia varies depending on the surgery to be performed, and therefore, when general anesthésia is used, in order to satisfy the respective requirements for general anesthésia, a sédative, an analgésie, a muscle relaxant, etc. are administered while adjusting the doses thereof according to the type of surgery and the individual patient. Such a technique is called balanced anesthésia and has been regarded as a highly valuable technique for achieving idéal anesthésia while minimizing side effects of respective agents by combining various agents. [0003]
Sédatives which are used in general anesthésia to cause loss of consciousness in a patient and maintain the State of loss of consciousness are roughly divided into an intravenous anesthetic and an inhalational anesthetic. The intravenous anesthetic has advantages not shared by an inhalational anesthetic, for example, the intravenous anesthetic can be used with a relatively simple device, there is no stage of excitement at the time of induction of general anesthésia, contamination in the surgery room or air is not caused, etc. Therefore, since a product containing propofol was placed on the market in 1995, the intravenous anesthetic has spread rapidly in Japan. Further, in 2007, a product containing remifentanil hydrochloride, which is a short-acting narcotic analgésie and can be intravenously administered, and a product containing rocuronium bromide, which is a muscle relaxant and can be intravenously administered, were placed on the market in succession, and a total intravenous anesthésia (TIVA) technique which satisfies ail of the requirements necessary for general anesthésia using agents which can be continuously and intravenously administered is gradually spreading. [0004]
As the intravenous anesthetic for the purpose of sédation, a product containing, as an active ingrédient, propofol, midazolam, thiamylal sodium, or the like has been often used. [0005]
The duration of sédative effect of propofol is short, and even if propofol is administered for a long time, the time from completion of administration to recovery from anesthésia is short, and therefore, propofol is used for the induction and maintenance of general anesthésia. However, propofol has been known to hâve problems that circulatory dépréssion such as hypotension, occurrence of angialgia, risk of microbial contamination, and intraoperative awakening are likely to be caused, a burning sensation is caused due to the activation of TRPA1 channel, etc. Further, it has been noted that propofol has a risk of causing propofol infusion syndrome, although the occurrence is rare. The propofol infusion syndrome is a disease caused in a patient to whom propofol has been administered for long-term sédation in an intensive care unit and is a fatal complication in which metabolic acidosis, dyslipidemia, and multiple organ failure progress to cause bradyarrhythmia and lead to cardiac arrest.
[0006]
On the other hand, midazolam, which is a benzodiazépine hypnotic, has advantages that the circulatory dépressive effect is lower than propofol, it has an amnésie effect useful for the prévention of a posttraumatic stress disorder due to intraoperative awakening, there is an antagonist therefor, etc. However, the duration of sédative effect of midazolam is long, and therefore, it is necessary to use midazolam by intermittent administration not by continuous administration, and midazolam is not so suitable for practical use in the induction and maintenance of general anesthésia. In addition, if midazolam is administered for a long time, recovery from anesthésia after stopping the administration is delayed, and therefore, a time until a patient can leave the surgery room is prolonged to increase the burden on the patient and also the medical staff is tied down for a long time. [0007]
Further, thiamylal sodium exhibits a sédative effect rapidly at the time of induction of general anesthésia and a time until recovery from anesthésia after stopping the administration is short, and therefore thiamylal sodium is used for the induction of general anesthésia. However, similarly to midazolam, if thiamylal sodium is administered for a long time, recovery from anesthésia after stopping the administration is delayed, and therefore, thiamylal sodium is not used for the purpose of maintenance of general anesthésia.
[0008]
As described above, intravenous anesthetics for the purpose of sédation currently used in a clinical site hâve advantages and disadvantages, respectively, and the development of a novel intravenous anesthetic having only the respective advantages has been demanded.
[0009]
On the other hand, methyl
3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate is a benzodiazépine compound disclosed in WO 2000/069836, and it is described that the compound is a short-acting central nervous system depressant that is useful for intravenous administration in the following clinical settings: preoperative sédation, anxiolysis, and amnestic use for perioperative events; conscious sédation during short diagnostic, operative or endoscopie procedures; as a component for the induction and maintenance of general anesthésia prior and/or concomitant to the administration of other anesthetics; and ICU sédation. Further, it is described that this compound may form a pharmaceutically acceptable sait with benzenesulfonic acid or the like, and by intravenously administering such a compound through bolus injection, preferably continuous infusion to a mammal at a dose of from 0.01 to 5.0 mg/kg of body weight, and preferably from 0.02 to 0.5 mg/kg of body weight, a sédative or hypnotic effect can be obtained (see Patent Document 1). [0010]
Further, for example, in WO 2008/007071, a benzenesulfonic acid sait of methyl
3-[ (4S) -8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate and a crystalline polymorphism thereof are disclosed (see Patent Document 2). [0011]
Further, for example, in WO 2012/062439, a method for obtaining a sédative effect by administering methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate, a sait thereof, or a solvaté thereof in combination with an opioid at a dose of from 2 to 10 mg is disclosed (see Patent Document 3). [0012]
Still further, for example, in Anesthésia and Analgesia, vol. 115, pp. 274-283, 2012 and Anesthésia and Analgesia, vol. 115, pp. 284-296, 2012, the évaluation results obtained by comparing safety, tolerability, pharmacokinetics, pharmacological effects, etc. between a placebo and midazolam when performing single intravenous administration of 6 i remimazolam (methyl
3-[( 4 S )-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate ) over 1 minute in a double-blind manner are described (see Non-Patent Documents 1 and 2).
[0013]
Further, for example, in British Journal of Pharmacology, vol. 155, pp. 52-61, 2008 and British Journal of Anaesthesia, vol. 105, No. 6, pp. 798-809, 2010, it is described that continuons intravenous injection to sheep was performed for 2 minutes using CNS 7056 (methyl
3—[ (4 S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate) (see Non-Patent Documents 3 and 4).
[0014]
As described above, when general anesthésia is introduced, a plurality of agents are simultaneously applied to a patient, and it is by no means rare that by combining a plurality of agents, an adverse effect is exhibited in a patient or a desired drug efficacy cannot be obtained. Also, it is not difficult to predict that a possibility of the onset of toxicity is increased by performing the long-term continuons administration of a compound even if the compound has been confirmée! to be safe in single administration or short-term continuous administration.
[0015]
For example, it is known that sensitivity to a benzodiazépine compound is increased in the elderly and also it is said that the sensitivity varies depending on the gender. It is true in the case of a narcotic analgésie. For example, it is said that the clearance of remifentanil is decreased by 25% in patients at the âge of 65 or more, and also that a time until the concentration of remifentanil in plasma reaches equilibrium with that in the site of action is delayed. Further, in general, when a benzodiazépine compound is used in combination with a narcotic analgésie, a synergistic effect is obtained, and therefore, it is considered that when these compounds are used in combination, the respective doses should be decreased.
[0016]
In the case where a novel dosing regimen such as long-term continuons administration is to be employed by using a plurality of agents in combination, it is not sufficient that safety in the single administration of each agent has been confirmed, and a method capable of obtaining a safer and more adéquate drug efficacy should be selected in considération of the interaction by the combination of such agents, the toxicity and accumulation of the compounds or métabolites thereof by long-term continuons administration, etc. [0017]
However, in the case where a sédative comprising methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate or a sait thereof is to be administered to a patient for the purpose of the induction and/or maintenance of general anesthésia, since such a compound has been continuously administered to sheep for only 2 minutes and to a human for only 1 minute, specifically what dosing regimen should be used for the compound was totally unknown so as to be able to use the compound as a safe and useful general anesthetic having the advantages of propofol (for example, the adjustability is high, and a recovery time from anesthésia after stopping the administration is short) and the advantages of midazolam, which is a benzodiazépine hypnotic (for example, the activity of causing circulatory dépréssion such as hypotension is low, and there is an antagonist for midazolam) in the case where the compound is used in combination with other concomitant agents as well as in the case where the compound is used alone. [Prior Art Documents] [Patent Documents] [0018]
[Patent Document 1] WO 2000/069836
[Patent Document 2] WO 2008/007071
[Patent Document 3] WO 2012/062439
[Non-Patent Documents]
[0019]
[Non-Patent Document 1] Anesthésia and Analgesia, vol. 115, pp. 274-283, 2012
[Non-Patent Document 2] Anesthésia and Analgesia, vol. 115, pp. 284-296, 2012
[Non-Patent Document 3] British Journal of Pharmacology, vol. 155, pp. 52-61, 2008
[Non-Patent Document 4] British Journal of Anaesthesia, vol. 105, No. 6, pp. 798-809, 2010 [Summary of the Invention] [Problems that the Invention is to Solve] [0020]
An object of the invention is to provide a most suitable dosing regimen of a sédative comprising, as an active ingrédient, methyl
3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate or a sait thereof when it is used for the induction and/or maintenance of general anesthésia.
[Means for Solving the Problems] [0021]
The présent inventors made intensive studies in order to achieve the above object, and as a resuit, they found that the below-described spécifie dosing regimen is most suitable when a sédative comprising, as an active ingrédient, methyl
3-[ (4 S)-8-bromo-l-methyl-6-( 2-pyridinyl)-4H-imidazo[1,2-a]
[ 1,4]benzodiazepin-4-yl]propanoate or a sait thereof is used for the induction and/or maintenance of general anesthésia, and then, further made intensive studies, thereby completing the invention.
[0022]
That is, the présent invention relates to:
[A01] An agent which is a sédative comprising, as an active ingrédient, methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-y1]propanoate or a sait thereof, wherein the dosing rate of the active ingrédient by intravenous administration is about 0.3 mg to about 40 mg/hour/kg in a patient who needs a treatment with the agent;
[A02] the agent according to the above [A01], wherein the active ingrédient is methyl
3-[ (4 S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate;
[A03] the agent according to the above [A01] or [A02], which is used for the induction and/or maintenance of general anesthésia;
[A04] the agent according to any one of the above [A01] to [A03] , which is used for (1) the induction and maintenance of general anesthésia or (2) the induction of general anesthésia;
[A05] the agent according to the above [A03] or [A04], which is used in combination with a narcotic analgésie and optionally a muscle relaxant;
[A06j the agent according to the above [A03] or [A04], which induces loss of consciousness in the patient within about 180 seconds after the intravenous administration is started;
[A07] the agent according to the above [A04], wherein the agent is used for the induction and maintenance of general anesthésia, and the intravenous administration includes a two-step administration process;
[A08] the agent according to the above [A07], wherein the two-step administration process includes: a first step for the induction of general anesthésia, in which the dosing rate of the active ingrédient by intravenous administration is about 3 mg to about 40 mg/hour/kg in a patient who needs a treatment with the agent; and a second step for the maintenance of general anesthésia, in which the dosing rate of the active ingrédient by intravenous administration is about 0.3 mg to about 2.5 mg/hour/kg in a patient who needs a treatment with the agent;
[A09] the agent according to the above [A08], wherein, in the first step, the dosing rate of the active ingrédient by intravenous administration is about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the agent;
[A10] the agent according to the above [A08] or [A09], wherein, in the first step, the dosing rate of the active ingrédient by intravenous administration is about 4 mg, about mg, about 8 mg, about 12 mg, about 21 mg, or about 30 mg/hour/kg in a patient who needs a treatment with the agent;
[Ail] the agent according to any one of the above [A08] to [A10], wherein, in the first step, the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the agent;
[A12] the agent according to any one of the above [A08] to [Ail], wherein the patient is 20 years old or older and younger than 65 years old;
[A13] the agent according to the above [A12], wherein, in the first step, the dosing rate of the active ingrédient by intravenous administration is about 6 mg, about 12 mg, about 21 mg, or about 30 mg/hour/kg in a patient who needs a treatment with the agent;
[A14] the agent according to the above [A12] or [A13], wherein, in the first step, the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the agent;
[Ά15] the agent according to any one of the above [A08] to [A10], wherein the patient is 65 years old or older;
[A16] the agent according to the above [A15], wherein, in the first step, the dosing rate of the active ingrédient by intravenous administration is about 4 mg, about 8 mg, or about 12 mg/hour/kg in a patient who needs a treatment with the agent;
[A17] the agent according to the above [A15], wherein, in the first step, the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the agent;
[A18] the agent according to the above [A08], wherein, in the second step, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 2 mg/hour/kg in a patient who needs a treatment with the agent;
[A19] the agent according to any one of the above [A08] to [A14] and [A18] , wherein the patient is 20 years old or older and younger than 65 years old;
[A20] the agent according to the above [A19], wherein, in the second step, the dosing rate of the active ingrédient by intravenous administration is about 0.8 mg to about 2 mg/hour/kg in a patient who needs a treatment with the agent;
[A21] the agent according to the above [A19], wherein, in the second step, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the agent;
[A22] the agent according to any one of the above [A19] to [A21], wherein, in the second step, the dosing rate of the active ingrédient by intravenous administration is about 1 mg/hour/kg in a patient who needs a treatment with the agent;
[A23] the agent according to any one of the above [A08] to [Ail] and [A15] to [A18], wherein the patient is 65 years old or older;
[A24] the agent according to the above [A23], wherein, in the second step, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the agent;
[A25] the agent according to the above [A23] or [A24], wherein, in the second step, the dosing rate of the active ingrédient by intravenous administration is about 1 mg/hour/kg in a patient who needs a treatment with the agent;
[A26] the agent according to the above [A04], wherein the agent is used for the induction of general anesthésia, and the intravenous administration includes a one-step administration process;
[A27] the agent according to the above [A26], wherein the patient is 20 years old or older, and the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the agent;
[A28] an agent for inducing loss of consciousness in a patient within about 180 seconds after intravenous administration is started, wherein the agent is a sédative comprising, as an active ingrédient, methyl 3 —[(4 S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a]
[1, 4]benzodiazepin-4-yl]propanoate benzenesulfonate, and is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the agent and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 2 mg/hour/kg in a patient who needs a treatment with the agent;
[A29] the agent according to the above [A05] or [A28], wherein the narcotic analgésie is remifentanil;
[A30] the agent according to the above [A05], [Ά28], or [A29], wherein the muscle relaxant is rocuronium bromide;
[A31] the agent according to the above [A01], [A28], [A29], or [A30], wherein the incidence rate of hypotension as a side effect is less than 15%;
[0023]
[B01] a sédative comprising, as an active ingrédient, methyl
3-[(4 S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [ 1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, which is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, wherein the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 6 mg/hour/kg in a patient who needs a treatment with the sédative and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the sédative;
[B02] a sédative comprising, as an active ingrédient, methyl
3-[ (4 S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a]
[1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, which is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, wherein the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 12 mg/hour/kg in a patient who needs a treatment with the sédative and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the sédative;
[B03] a sédative comprising, as an active ingrédient, methyl
3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a]
[ 1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, which is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction of general anesthésia, wherein the dosing rate of the active ingrédient by intravenous administration is about 6 mg/hour/kg in a patient who needs a treatment with the sédative;
[B04] a sédative comprising, as an active ingrédient, methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a]
[ 1,4]be nzodiazepin-4-yl]propanoate benzenesulfonate, which is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction of general anesthésia, wherein the dosing rate of the active ingrédient by intravenous administration is about 12 mg/hour/kg in a patient who needs a treatment with the sédative;
[0024]
[COI] a product comprising (1) a pharmaceutical composition comprising, as an active ingrédient, methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a]
[1,4]ben zodiazepin-4-yl]propanoate benzenesulfonate, (2) a container, and (3) an instruction, a manual, an appendix, or a product label, indicating that the active ingrédient can be used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia by intravenous administration in a two-step administration process;
[C02] the product according to the above [COI], wherein the two-step administration process includes: a first step for the induction of general anesthésia, in which the dosing rate is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the product; and a second step for the maintenance of general anesthésia, in which the dosing rate is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the product;
[C03] a product comprising (1) a pharmaceutical composition comprising, as an active ingrédient, methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, (2) a container, and (3) an instruction, a manual, an appendix, or a product label, indicating that the active ingrédient can be used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction of general anesthésia by intravenous administration at a dosing rate of about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the product;
[0025]
[D01] an instruction, amanual, an appendix, or a product label, indicating that methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate can be used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia by intravenous administration in a two-step administration process;
[D02] the instruction, manual, appendix, or product label according to the above [D01], wherein the two-step administration process includes : a first step for the induction of general anesthésia, in which the dosing rate is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the compound; and a second step for the maintenance of general anesthésia, in which the dosing rate is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the compound;
[D03] an instruction, amanual, an appendix, or a product label, indicating that methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate can be used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction of general anesthésia by ‘ .1 intravenous administration at a dosing rate of about 6 mg or about 12 mg mg/hour/kg in a. patient who needs a treatment with the compound;
[D04] a method for advertising a pharmaceutical composition comprising, as an active ingrédient, methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, comprising notifying to a target viewer the matter that the active ingrédient can be used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia by intravenous administration in a two-step administration process, thereby promoting the use of the composition;
[D05] the method according to the above [D04], wherein the two-step administration process includes: a first step for the induction of general anesthésia, in which the dosing rate is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the composition; and a second step for the maintenance of general anesthésia, in which the dosing rate is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the composition;
[D06] a method for advertising a pharmaceutical composition comprising, as an active ingrédient, methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, comprising notifying to a target viewer the matter that the active ingrédient can be used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction of general anesthésia by intravenous administration at a dosing rate of about 6 mg or about 12 mg mg/hour/kg in a patient who needs a treatment with the composition, thereby promoting the use of the composition;
[0026]
[E01] a method which is a sédative method including intravenously administering an effective amount of methyl 3 —[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [ 1,4]benzodiazepin-4-yl]propanoate or a sait thereof, which is an active ingrédient, to a patient who needs a treatment with the compound, wherein the dosing rate of the active ingrédient by intravenous administration is about 0.3 mg to about 40 mg/hour/kg in a patient who needs a treatment with the compound;
[E02] a method for inducing loss of consciousness in a patient within about 180 seconds after the intravenous administration is started, which is a sédative method including intravenously administering an effective amount of methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, which is an active ingrédient, to a patient who needs a treatment with the compound, wherein the method is performed using the d 1 compound in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the compound and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 2 mg/hour/kg in a patient who needs a treatment with the compound;
[E03] a method which is a sédative method including intravenously administering an effective amount of a benzodiazépine sédative comprising methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate as an active ingrédient to a patient who needs a treatment with the sédative, wherein the method is performed using the sédative in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, the intravenous administration of the active ingrédient includes a two-step administration process including a first step for the induction of general anesthésia and a second step for the maintenance of general anesthésia, and loss of consciousness is induced in a patient within about 180 seconds after the administration of the benzodiazépine sédative is started at a dosing rate of about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the sédative in the first step, recovery of consciousness occurs in a patient under general anesthésia within about 30 minutes after stopping the administration of the benzodiazépine sédative at a dosing rate of about 0.4 mg to about 2 mg/hour/kg in a patient who needs a treatment with the sédative in the second step, and the incidence rate of hypotension as a side effect is less than 15%;
[E04] a method which is a sédative method including intravenously administering an effective amount of methyl 3-[ (4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [ 1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, which is an active ingrédient, to a patient who needs a treatment with the compound, wherein the method is performed using the compound in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the compound and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about
0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the compound;
[0027]
[FOI] methyl
3-[(43)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate or a sait thereof for inducing a sédative state, wherein the dosing rate of the compound by intravenous administration is about 0.3 mg to about 40 mg/hour/kg in a patient who needs a treatment with the compound;
[F02] methyl
3-[(43)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate for inducing a sédative state, wherein the compound is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the compound and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 2 mg/hour/kg in a patient who needs a treatment with the compound, and loss of consciousness is induced in a patient within about 180 seconds after the intravenous administration thereof is started;
[F03] methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate for inducing a sédative state, which is a benzodiazépine compound for intravenous administration, wherein the compound is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, the intravenous administration of the compound includes a two-step administration process including a first step for the induction of general anesthésia and a second step for the maintenance of general anesthésia, and loss of consciousness is induced in a patient within about 180 seconds after the administration of the benzodiazépine compound is started at a dosing rate of about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the compound in the first step, recovery of consciousness occurs in a patient under general anesthésia within about 30 minutes after stopping the administration of the benzodiazépine compound at a dosing rate of about 0.4 mg to about 2 mg/hour/kg in a patient who needs a treatment with the compound in the second step, and the incidence rate of hypotension as a side effect is less than
15%;
[F04] methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate for inducing a sédative state, wherein the compound is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the compound, and in a second step for maintenance of general anesthésia, the dosing rate of the active ingrédient is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the compound;
[0028]
[G01] use of methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate or a sait thereof for producing a sédative, wherein the dosing rate of the compound by intravenous administration is about 0.3 mg to about 40 mg/hour/kg in a patient who needs a treatment with the compound;
[G02] use of methyl
3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [ 1,4]benzodiazepin-4-yl]propanoate benzenesulfonate as an active ingrédient for producing a sédative which induces loss of consciousness in a patient within about 180 seconds after the intravenous administration thereof is started, wherein the compound is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the compound and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 2 mg/hour/kg in a patient who needs a treatment with the compound;
[G03] use of methyl —[(4 S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate as an active ingrédient for producing a benzodiazépine sédative for intravenous administration, wherein the compound is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, the intravenous administration of the compound includes a two-step administration process including a first step for the induction of general anesthésia and a second step for the maintenance of general anesthésia, and loss of consciousness is induced in a patient within about 180 seconds after the administration of the benzodiazépine sédative is started at a dosing rate of about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the compound in the first step, recovery of consciousness occurs in a patient under general anesthésia within about 30 minutes after stopping the administration of the benzodiazépine sédative at a dosing rate of about 0.4 mg to about 2 mg/hour/kg in a patient who needs a treatment with the compound in the second step, and the incidence rate of hypotension as a side effect is less than 15%;
[G04] use of methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [ 1,4]benzodiazepin-4-yl]propanoate benzenesulfonate as an active ingrédient for producing a sédative, wherein the compound is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the compound, and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about . 4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the compound;
[0029]
[H01] a sédative, which is a benzodiazépine sédative to be used for the induction and maintenance of general anesthésia by continuous intravenous administration, wherein loss of consciousness is induced in a patient within about 180 seconds after the administration of the benzodiazépine sédative is started at a dosing rate necessary for the induction of general anesthésia in the patient;
[H02] a sédative, which is a benzodiazépine sédative to be used for the induction and maintenance of general anesthésia by continuous intravenous administration, wherein recovery of consciousness occurs in a patient under general anesthésia within about 30 minutes after stopping the administration of the benzodiazépine sédative at a dosing rate necessary for the maintenance of general anesthésia in the patient;
[H03] a sédative, which is a benzodiazépine sédative to be used for the induction and maintenance of general anesthésia by continuous intravenous administration, wherein loss of consciousness is induced in a patient within about 180 seconds after the administration of the benzodiazépine sédative is started at a dosing rate necessary for the induction of general anesthésia in the patient, and recovery of consciousness occurs in a patient under general anesthésia within about 30 minutes after stopping the administration of the benzodiazépine sédative at a dosing rate necessary for the maintenance of general anesthésia in the patient;
[H04] the sédative according to any one of the above [H01] to [H03] , wherein the benzodiazépine sédative comprises methyl 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[l,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate as an active ingrédient;
[H05] the sédative according to the above [H04], wherein the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the sédative, and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 2 mg/hour/kg in a patient who needs a treatment with the sédative;
[H06] the sédative according to the above [H04] or [H05], wherein the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the sédative, and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the sédative;
[H07] the sédative according to the above [H04], [H05], or [H06] , wherein the incidence rate of hypotension as a side effect is less than 15%;
[H08] a sédative, which is a benzodiazépine sédative for intravenous administration comprising, as an active ingrédient, methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, wherein the sédative is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, the intravenous administration of the active ingrédient includes a two-step administration process including a first step for the induction of general anesthésia and a second step for the maintenance of general anesthésia, and loss of consciousness is induced in a patient within about 180 seconds after the administration of the benzodiazépine sédative is started at a dosing rate of about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the sédative in the first step, recovery of consciousness occurs in a patient under general anesthésia within about 30 minutes after stopping the administration of the benzodiazépine sédative at a dosing rate of about 0.4 mg to about 2 mg/hour/kg in a patient who needs a treatment with the sédative in the second step, and the incidence rate of hypotension as a side effect is less than 15%;
[H09] a sédative, which is a benzodiazépine sédative for intravenous administration comprising, as an active ingrédient, methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, wherein the sédative is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, the intravenous administration of the active ingrédient includes a two-step administration process including a first step for the induction of general anesthésia and a second step for the maintenance of general anesthésia, and loss of consciousness is induced in a patient within about 180 seconds after the administration of the benzodiazépine sédative is started at a dosing rate of about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the sédative in the first step, recovery of consciousness occurs in a patient under general anesthésia within about 30 minutes after stopping the administration of the benzodiazépine sédative at a dosing rate of about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the sédative in the second step, and the incidence rate of hypotension as a side effect is less than 15%;
[0030]
[J01] an agent for inducing general anesthésia comprising, as an active ingrédient, methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate or a sait thereof, wherein the dosing rate of the active ingrédient by intravenous administration is about 3 mg to about 40 mg/hour/kg in a patient who needs a treatment with the agent;
[J02] an agent for inducing general anesthésia comprising, as an active ingrédient, methyl 3-[ (4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1, 4]benzodiazepin-4-yl]propanoate or a sait thereof, wherein the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the agent;
[J03] the agent according to any one of the above [J01] or [J02], wherein the active ingrédient is methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate;
[J04] the agent according to any one of the above [J01] to [ J03] , which is used in combination with a narcotic analgésie and optionally a muscle relaxant;
[0031]
[KOI] an agent for maintaining general anesthésia comprising, as an active ingrédient, methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate or a sait thereof, wherein the dosing rate of the active ingrédient by intravenous administration is about 0.3 mg to about 2.5 mg/hour/kg in a patient who needs a treatment with the agent;
[K02] an agent for maintaining general anesthésia comprising, as an active ingrédient, methyl 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate or a sait thereof, wherein the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the agent;
[K03] the agent according to the above [KOI] or [K02], wherein the active ingrédient is methyl 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate;
[K04] the agent according to any one of the above [KOI] to [K03], wherein the agent is used in combination with a narcotic analgésie and optionally a muscle relaxant;
[0032]
[LOI] an agent for inducing and maintaining general anesthésia comprising, as an active ingrédient, methyl 3-[(43)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate or a sait thereof, wherein the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 3 mg to about 40 mg/hour/kg in a patient who needs a treatment with the agent, and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.3 mg to about 2.5 mg/hour/kg in a patient who needs a treatment with the agent;
[1102] an agent for inducing and maintaining general anesthésia comprising, as an active ingrédient, methyl 3-[(43)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [ 1,4]benzodiazepin-4-yl]propanoate or a sait thereof, wherein the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the agent, and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the agent;
*1
[L03] the agent according to the above [LOI] or [L02], wherein the active ingrédient is methyl
3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a]
[1,4]benzodiazepin-4-y1]propanoate benzenesuifonate;
[L04] the agent according to any one of the above [LOI] to [L03 ], wherein the agent is used in combination with a narcotic analgésie and optionally a muscle relaxant;
[0033]
[MOI] a dosing regimen of methyl 3-[ (4 S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1, 4]benzodiazepin-4-yl]propanoate benzenesulfonate for the induction and maintenance of general anesthésia;
[M02] a dosing regimen of a sédative comprising methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate for the induction and maintenance of general anesthésia;
[M03] the dosing regimen according to the above [MOI] or [M02], wherein the incidence rate of hypotension as a side effect is less than 15%;
[0034]
[N01] a sédative comprising, as an active ingrédient, methyl
3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate or a sait thereof, wherein the sédative is intravenously administered to a patient who needs a treatment with the sédative for more than 2 minutes for inducing and maintaining general anesthésia;
[N02] the sédative according to the above [N01], wherein the active ingrédient is methyl
3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-y1]propanoate benzenesuifonate;
[N03] the sédative according to the above [N01] or [N02] , wherein the intravenous administration includes a two-step administration process;
[N04] the sédative according to the above [N03] , wherein the two-step administration process includes: a first step for the induction of general anesthésia, in which the dosing rate of the active ingrédient by intravenous administration is about 3 mg to about 40 mg/hour/kg in a patient who needs a treatment with the sédative; and a second step for the maintenance of general anesthésia, in which the dosing rate of the active ingrédient by intravenous administration is about 0.3 mg to about 2.5 mg/hour/kg in a patient who needs a treatment with the sédative;
[N05] the sédative according to the above [N03] or [N04], wherein the two-step administration process includes: a first step for the induction of general anesthésia, in which the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the sédative; and a second step for the maintenance of general anesthésia, in which the dosing rate of the active ingrédient by intravenous administration is about
0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the sédative;
[NO6] the sédative according to any one of the above [N01] to [N05] , which is used in combination with a narcotic analgésie and optionally a muscle relaxant;
[N07] the sédative according to any one of the above [N01] to [N06], which induces loss of consciousness in the patient within about 180 seconds after the intravenous administration is started;
[N08] the sédative according to any one of the above [N01] to [N07], wherein the incidence rate of hypotension as a side effect is less than 15%;
[N09] a sédative which induces loss of consciousness in a patient within about 180 seconds after the intravenous administration is started, wherein the sédative comprises, as an active ingrédient, methyl
3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4] benzodiazepin-4- y 1 ] propanoate benzenesulf onate, is used in combination with a narcotic analgésie and optionally a muscle relaxant, and is intravenously administered to a patient who needs a treatment with the sédative for more than 2 minutes for inducing and maintaining general anesthésia, the intravenous administration includes a two-step administration û<
process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the sédative and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 2 mg/hour/kg in a patient who needs a treatment with the sédative;
[N10] a sédative which induces loss of consciousness in a patient within about 180 seconds after the intravenous administration is started, wherein the sédative comprises, as an active ingrédient, methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4] benzodiazepin-4- y 1 ] propanoate benzenesulf onate, is used in combination with a narcotic analgésie and optionally a muscle relaxant, and is intravenously administered to a patient who needs a treatment with the sédative for more than 2 minutes for inducing and maintaining general anesthésia, the intravenous administration includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the sédative and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the sédative;
[Nil] a sédative comprising, as an active ingrédient, methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, wherein the sédative is used in combination with a narcotic analgésie and optionally a muscle relaxant and is intravenously administered to a patient who needs a treatment with the sédative for more than 2 minutes for inducing and maintaining general anesthésia, the intravenous administration includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the sédative and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 2 mg/hour/kg in a patient who needs a treatment with the sédative, and in the first step, loss of consciousness is induced in a patient within about 180 seconds after the intravenous administration is started, and in the second step, an adéquate depth of anesthésia is ensured in a patient during surgery; and
[N12] a sédative comprising, as an active ingrédient, methyl
3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, wherein the sédative is used in combination with a narcotic analgésie and optionally a muscle relaxant and is intravenously administered to a patient who needs a treatment with the sédative for more than 2 minutes for inducing and maintaining general anesthésia, the intravenous administration includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the sédative and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the sédative, and in the first step, loss of consciousness is induced in a patient within about 180 seconds after the intravenous administration is started, and in the second step, an adeguate depth of anesthésia is ensured in a patient during surgery. [Advantage of the Invention] [0035]
According to the invention, a dosing regimen of a sédative comprising methyl
3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a]
[ 1,4]benzodiazepin-4-yl]propanoate, which is a benzodiazépine compound, or a sait thereof is disclosed. The dosing regimen is most suitable when using the benzodiazépine compound for the induction and maintenance of general anesthésia and employs intravenous administration, and therefore is particularly useful for total intravenous anesthésia (TIVA). By using the dosing regimen of the invention, rapid loss of consciousness is caused to place a patient in a state of general anesthésia after the administration is started and also rapid recovery of consciousness occurs after stopping the administration and recovery from the state of general anesthésia can be achieved. In addition, a side effect such as hypotension is mild and an adéquate depth of anesthésia can be maintained, and therefore, intraoperative awakening does not occur. Even if intraoperative awakening occurs, the benzodiazépine compound is expected to exhibit an amnésie effect based on the benzodiazépine skeleton of the compound so as not to cause a posttraumatic stress disorder due to the memory upon awakening during surgery.
[Mode for Carrying Out the Invention] [0036]
In the invention, methyl
3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [ 1,4]benzodiazepin-4-yl]propanoate (hereinafter sometimes 43 abbreviated as Compound A) is a known compound represented by the following formula (A) , and is described in, for example,
Example le-8 in WO 2000/069836. The compound is s orne time s also referred to as remimazolam or CNS 7056.
[Chemical 1]
(A)
[0037]
In the invention, unless otherwise specified, as apparent to those skilled in the art, the symbol [Chemical 2] indicates a bond going behind the plane of the paper (that is, α-configuration); the symbol [Chemical 3] indicates a bond coming out of the plane of the paper (that is, β-configuration); and the symbol [Chemical 4] indicates an α-configuration, β-configuration, or a mixture thereof at an arbitrary ratio.
[0038]
In the invention, examples of the sait of methyl 3-[ (4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [ 1,4]benzodiazepin-4-yl]propanoate include salts described in WO 2000/069836 such as hydrochlorides, hydrobromides, sulfates, nitrates, phosphates, salicylates, p-toluenesulfonates, tartarates, citrates, methanesulfonates, maleates, formates, malonates, succinates, isethionates, lactobionates, naphthalene-2-sulfonates, sulfamates, ethanesulfonates, and benzenesulfonates. [0039]
In the invention, as one of the preferred embodiments of Compound A and a sait thereof, methyl 3-[ (4 S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate can be exemplified. Methyl
3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate (hereinafter sometimes abbreviated as Compound B) is a known compound represented by the following formula (B), and is described in, for example, WO 2008/007071 as a besilate. [Chemical 5]
[0040]
In the invention, Compound A or a sait thereof and Compound B can be produced by appropriately combining known methods, for example, methods described in WO 2000/069836, WO 2008/007071, WO 2008/007081, WO 2011/032692, and WO 2012/062439, or similar methods thereto, etc. In addition, such a compound can also be produced by using general methods other than the above methods, for examples, methods described in Comprehensive Organic Transformations: A Guide to Functional Group Préparations, 2nd Edition (Richard C. Larock, John Wiley & Sons, Inc., 1999), etc., or partially modified methods thereof, etc. in an appropriate combination. [0041]
Compound A or a sait thereof and Compound B are grouped in a benzodiazépine compound based on the structure thereof. Further, midazolam having the following structure is also grouped in a benzodiazépine compound.
6
[Chemical 6]
[0042]
The benzodiazépine compound is a collective term of a group of compounds having a partial structure of a bicyclic heterocycle in which a benzene ring and a 7-membered ring having 2 nitrogen atoms are condensed in its structural formula. Many of the benzodiazépine compounds hâve an activity to induce hypnosis by activating the GABAa receptor to promote the inflow of chloride ions, and therefore are used as an active ingrédient of a sédative (a benzodiazépine sédative) as a benzodiazépine sédative agent. [0043]
In the invention, the sédative comprising Compound A or a sait thereof as an active ingrédient refers to a pharmaceutical composition comprising Compound A or a sait thereof as an active ingrédient for the induction of a sédative and/or sédative state in a mammal (preferably a human, more preferablya patient) which (who) receives the administration.
[0044]
Such a pharmaceutical composition may be any as long as it is a préparation obtained by formulation of Compound A or a sait thereof as an active ingrédient along with a variety of pharmaceutically acceptable carriers such as additives and solvents, however, a composition for intravenous administration is preferably used. Here, the pharmaceutically acceptable carrier refers to a substance other than the active ingrédient to be generally used in a pharmaceutical préparation. As the pharmaceutically acceptable carrier, a substance which does not exhibit a pharmacological effect at a dose of the préparation, is harmless, and does not inhibit the pharmacological effect of the active ingrédient is preferred. Further, the pharmaceutically acceptable carrier can be used also for the purpose of enhancing the usefulness of the active ingrédient and the préparation, facilitating the formulation, stabilizing the quality, improving the usability, etc. Specifically, a substance described in Japanese pharmaceutical excipients (edited by The Japan Pharmaceutical Excipients Council) published by YAKUJI NIPPO LIMITED in 2000 may be appropriately selected according to need. [0045]
The pharmaceutical composition for intravenous administration may be in the form of a solution, a suspension, an émulsion, or a solid stérile préparation (such as a lyophilized injection) which is used by dissolving or suspending immediately before use, and can be generally produced by the following method (a) , (b) or (c) :
(a) a method in which the active ingrédient as such or a mixture obtained by adding an additive to the active ingrédient is dissolved, suspended, or emulsified in an water for injection or another aqueous solvent or a non-aqueous solvent, etc. and then homogenized, and the resulting product is filled into a container for injection and the container is sealed, followed by sterilization;
(b) a method in which the active ingrédient as such or a mixture obtained by adding an additive to the active ingrédient is dissolved, suspended, or emulsified in an water for injection or another aqueous solvent or a non-aqueous solvent, etc. and then homogenized, followed by stérile filtration, or préparation is aseptically performed, followed by homogenization, and the resulting product is filled into a container for injection and the container is sealed; or (c) a method in which the active ingrédient as such or the active ingrédient and an additive such as an excipient, etc. is/are dissolved in an water for injection, followed by stérile filtration, and the resulting product is filled into a container for injection and thereafter lyophilized, or the resulting product is lyophilized in a dedicated container and thereafter directly filled into a container.
[0046]
The invention discloses a dosing regimen for using a sédative comprising Compound A or a sait thereof as an active ingrédient for the induction and/or maintenance of general anesthésia, that is, (1) the induction of general anesthésia, (2) the maintenance of general anesthésia, or (3) the induction and maintenance of general anesthésia, and further, the invention is characterized by the dosing regimen. [0047]
In the invention, the induction of general anesthésia refers to a treatment of placing a patient who is not in a state of general anesthésia in a state of general anesthésia. Specifically, the induction of general anesthésia is performed by administering an agent for inducing general anesthésia in an amount necessary for inducing general anesthésia to a patient. That is, in the invention, the induction of general anesthésia can be performed by administering a sédative comprising Compound A or a sait thereof as an active ingrédient in an amount necessary for inducing general anesthésia to a patient.
[0048]
Whether or not the patient is in a state of general anesthésia can be determined by the presence or absence of consciousness in the patient. Whether or not the patient is conscious after the induction of general anesthésia is started can be determined by, for example, asking a simple question requiring a response of the patient or observing a response to physical stimulation applied to the body of the patient, etc. An example of a simple procedure for determining whether or not the patient is conscious is as follows. For example, a procedure in which the patient is made to count aloud along with the induction of general anesthésia, and after the patient stops counting aloud, the shoulder of the patient is shaken or the like can be exemplified. It can be determined that if the patient does not respond when the shoulder is shaken, the patient is not conscious, if the patient responds, the patient is conscious.
[0049]
In the invention, the maintenance of general anesthésia refers to a treatment of maintaining the state of general anesthésia in a patient having been placed in a state of general anesthésia. Specifically, the maintenance of general anesthésia can be performed by administering an agent for maintaining general anesthésia in an amount necessary for maintaining general anesthésia to a patient. That is, in the invention, the maintenance of general anesthésia is performed by administering a sédative comprising Compound A or a sait thereof as an active ingrédient in an amount necessary for maintaining general anesthésia to a patient.
[0050]
In the invention, the induction and maintenance of general anesthésia refers to the induction of general anesthésia and the maintenance of general anesthésia are performed in succession. That is, in the invention, the induction and maintenance of general anesthésia can be performed by administering a sédative comprising Compound A or a sait thereof as an active ingrédient in an amount necessary for inducing general anesthésia to a patient so that the patient is placed in a state of general anesthésia, and subséquently, administering the sédative in an amount necessary for maintaining general anesthésia to the patient so that the state of general anesthésia is maintained. [0051]
Among the dosing regimens of the sédative comprising Compound A or a sait thereof disclosed in the invention, a dosing regimen to be used for the induction and maintenance of general anesthésia will be described in detail below as the dosing regimen of the invention. [0052]
The dosing regimen of the invention includes administering the sédative to a patient by a two-step administration process. More specifically, the administration process includes two steps in total, i.e., one step (first step) for the induction of general anesthésia and one step (second step) for the maintenance of general anesthésia. The Chemical concentration of the sédative for such an administration process is not particularly limited. It is not always necessary to use the Chemical in the same concentration in the first step and the second step. However, taking into considération convenience or the like in a clinical site, the Chemical concentration of the sédative to be used for the induction and maintenance of general anesthésia is preferably 1 mg/mL.
[0053]
In the dosing regimen of the invention, it is preferred that the sédative comprising Compound A or a sait thereof is administered continuously to a patient for more than 2 minutes in total in the first step and the second step.
[0054]
In the dosing regimen of the invention, the first step performed for the induction of general anesthésia includes intravenously administering Compound A or a sait thereof, which is the active ingrédient, to a patient who needs a treatment with the compound at a dosing rate of about 3 mg to about 40 mg/hour/kg in the patient, which constitutes one step.
[0055]
The dosing rate in the first step is preferably, for example, about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the compound, more preferably, for example, about 4 mg, about 6 mg, about 8 mg, about 12 mg, about 21 mg, or about 30 mg/hour/kg in a patient who needs a treatment with the compound. Particularly, the dosing rate is preferably about 6 mg or about 12 mg/hour/kg in a patient which needs a treatment with the compound. [0056]
In particular, in the case where the patient is a non-elderly adult, the dosing rate is preferably, for example, about 6 mg to about 30 mg/hour/kg in a patient who needs a treatment with the compound, and more preferably, for example, about 6 mg, about 12 mg, about 21 mg, or about 30 mg/hour/kg in a patient who needs a treatment with the compound. Above ail, the dosing rate is preferably not more than about 12 mg/hour/kg in a patient who needs a treatment with the compound, and therefore the dosing rate is preferably about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the compound. [0057]
On the other hand, in the case where the patient is an elderly adult, the dosing rate is preferably, for example, about 4 mg to about 12 mg/hour/kg in a patient who needs a treatment with the compound, and more preferably, for example, about 4 mg, about 8 mg, or about 12 mg/hour/kg in a patient 54 l . < 1 who needs a treatment with the compound. Further, within such a range of the dosing rate, the same dosing rate as in a non-elderly adult, namely about 6 mg or about 12 mg/hour/kg in a patient which needs a treatment with the compound, is also preferred.
[0058]
In the invention, an elderly adult refers to a patient who is 65 years old or older, and a non-elderly adult refers to a patient who is 20 years old or older and younger than 65 years old. [0059]
Further, in the invention, the dosing rate of Compound A or a sait thereof is expressed in, for example, about 12 mg/hour/kg in a patient who needs a treatment with the compound, however, it should be understood that 12 mg as used herein dénotés the amount of Compound A in a free form. In the case of using a sait, it should be understood that 12 mg dénotés the amount of Compound A contained in the sait and the amount of the sait should be calculated by adding the amount of an acid component constituting the sait (for example, in the case of Compound B, benzenesulfonic acid) to 12 mg. Accordingly, in the invention, in the case of using, as an active ingrédient, a sait of Compound A, in order to avoid ambiguousness, it is to be noted that the workings as the amount of Compound A may be properly compensated for the expression of the dosing rate . [0060]
In the dosing regimen of the invention, the second step which is performed for the maintenance of general anesthésia includes intravenous administration of Compound A or a sait thereof, which is the active ingrédient, to a patient who needs a treatment with the compound at a dosing rate of about 0.3 mg to about 2.5 mg/hour/kg in the patient, preferably about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the compound, and more preferably about 1 mg/hour/kg in a patient who needs a treatment with the compound, which constitutes one step. The second step is preferably performed for more than 2 minutes. [0061]
In the invention, the unit notation can be appropriately changed within a range that conforms to the standard scientific notation. For example, about 3 mg per hour per kilogram can be expressed as about 3 mg/kg/h or about 3 mg/kg/hr, and can also be expressed as about 0.05 mg/kg/min. [0062]
In the dosing regimen of the invention, it is preferred that the dosing rate of the active ingrédient in the single step is not changed, however, in the step for the maintenance of general anesthésia (second step), the dosing rate can be appropriately increased or decreased within a range of about
0.3 mg to about 2.5 mg/hour/kg in a patient who needs a treatment with the compound, and preferably within a range of about 2 mg at maximum in a patient who needs a treatment with the compound by using indexes of the general conditions of a patient, for example, signs of awakening of a patient or a BIS value in a patient, as an index. Specifically, for example, in the case of a non-elderly adult, the dosing rate can be appropriately increased or decreased within a range of about 0.4 mg to about 2 mg/hour/kg, specifically within a range of about 0.8 mg to about 2 mg/hour/kg or about 0.4 mg to about 1 mg/hour/kg, in a patient who needs a treatment with the compound, and for example, in the case of an elderly adult, the dosing rate can be appropriately increased or decreased within a range of about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the compound.
[0063]
Specifically, in the case where, for example, signs of awakening such as body motion, change in blood pressure or puise rate, lacrimation, or sweating are observed or a BIS value exceeds 53 in a patient in a state of maintenance of general anesthésia, the dosing rate of Compound A or a sait thereof, which is an active ingrédient, can be increased within the above range, and in the case where it is confirmed that a BIS value is 53 or less and signs of awakening are not observed, the dosing rate of Compound A or a sait thereof, which is an active ingrédient, can be decreased within the above range.
[0064]
The BIS as used herein stands for bispectral index, and refers to a parameter obtained by the numerical conversion of an electroencephalographic signal acquired by a sensor attached to the forehead using a calculation processing method developed by Aspect Medical Systems, Inc., and is used for monitoring the depth of anesthésia. The range of the BIS value is from 0 to 100, and a BIS value of 100 dénotés an awakening state, and as the depth of anesthésia is increased, the BIS value is decreased. During surgery using general anesthésia, the depth of anesthésia which gives a BIS value between 40 and 60 is considered to be appropriate. [0065]
In the case where a sédative comprising Compound A or a sait thereof as an active ingrédient is used for the induction and maintenance of general anesthésia in the dosing regimen of the invention, it is preferred to use the sédative in combination with an analgésie such as a narcotic analgésie or a local analgésie and if necessary, further with a muscle relaxant. It is more preferred to use the sédative in combination with a narcotic analgésie in the first step for the induction of general anesthésia, and in combination with a narcotic analgésie and a muscle relaxant in the second step for the maintenance of general anesthésia. The narcotic analgésies to be used in the first step and the second step may not necessarily be the same, and also the administration routes thereof may not necessarily be the same.
[0066]
In the invention, as the narcotic analgésie, a natural analgésie, a synthetic analgésie, or a semi-synthetic analgésie may be used as long as it is an analgésie which has been academically demonstrated to bind to an opioid receptor. However, a narcotic analgésie which exhibits an analgésie effect by intravenous administration is preferred. Examples of such a narcotic analgésie include remifentanil and fentanyl, and particularly preferred is remifentanil (such as remifentanil hydrochloride). [0067]
In the invention, the local analgésie is not particularly limited as long as it is a local analgésie which may be used for the analgésie purpose at the general anesthésia, and examples thereof include cocaïne, procaine, tetracaine, benzocaine, lidocaine, mepivacaine, bupivacaine, levobupivacaine, ropivacaine, prilocaine (propitocaine), dibucaine, and the like. [0068]
In the invention, as the muscle relaxant, a natural muscle relaxant, a synthetic muscle relaxant, or a semi-synthetic muscle relaxant may be used as long as it is a muscle relaxant to be used in anesthesiological practice. However, a muscle relaxant which exhibits a muscle relaxing effect by intravenous administration is preferred. Examples of such a muscle relaxant include rocuronium, vecuronium, and suxaméthonium, and particularly preferred is rocuronium (such as rocuronium bromide).
[0069]
In the case of using the muscle relaxant, it is preferred to monitor the degree of muscle relaxation in a patient. The degree of muscle relaxation can be easily determined by, for example, measuring a ΤΌΕ ratio using a frequently used device such as a TOF watch. [0070]
Here, the TOF ratio refers to a value obtained by a train of four method which is a method for evaluating the degree of muscle relaxation. Four separate stimuli are given at a frequency of 2 Hz. When the muscle is not relaxed, the ratio of the height of the fourth stimulus (T4) to that of the first stimulus (Tl) (TOF ratio: T4/T1) is substantially 100%, and as the degree of muscle relaxation is increased, the TOF ratio is decreased. A device for measuring the TOF ratio is a TOF watch, and in Japan, a TOF watch is available from MSD, Inc. (JMDN code: 35723003; approval No: 21100BZY00162000) . [0071]
According to a preferred embodiment of the dosing regimen of the invention, the dosing rate in the first step for the induction of general anesthésia is at most about 12 times faster than the dosing rate in the second step for the maintenance of general anesthésia. An appendix attached to a propofol injection (trade name: 1% Diprivan injection) currently available in Japan describes that the induction of general anesthésia is carried out at a dosing rate of 0.5 mg/kg/10 sec, and the maintenance of general anesthésia is carried out at a dosing rate of 4 to 10 mg/kg/h. When calculation was made using these dosing rates, the dosing rate in the first step for the induction of general anesthésia is 18 to 45 times faster than the dosing rate in the second step for the maintenance of general anesthésia. The fact that the time required for the induction of general anesthésia is substantially the same (about 1 to 2 minutes) and the rate for the induction of general anesthésia is slower indicates that by using the dosing regimen of the invention, a risk of overdosing at the time of induction of general anesthésia is further decreased. For example, Miller's Anesthésia, seventh édition, which is recognized as a standard of anesthetics, volume 1, page 724 describes that the most conspicuous effect during the use of propofol for the induction and maintenance of general anesthésia is a lowering of the arterial pressure at the induction of general anesthésia. That is, it may be said that the dosing regimen of the invention which reduces a risk of the occurrence of such an undesirable effect at the induction of general anesthésia is truly preferred.
[0072]
Further, the dosing regimen of the invention has overcome even a problem of vasostimulant which methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate is considered to possess potentially. For example, when Compound B is continuously intravenously administered to a non-human animal (for example, a monkey) at a dosing rate of 1 mg/kg/h to 2 mg/kg/h for several hours (for example, 4 hours to 6 hours) , there may be the case where vasostimulant is observed in the neighborhood of an effective dose. However, according to the dosing regimen of the invention, even in the case where the compound is administered in an amount per kg of the body weight equal to or more than that in the preceding test examples in which vasostimulant was observed, Compound B does not cause the vasostimulant. It can be said that this is an astonishingly excellent effect provided by the dosing regimen of the invention. [0073]
In the invention, in the case where the sédative comprising Compound A or a sait thereof is used only for the purpose of inducing general anesthésia not for the purpose of inducing and maintaining general anesthésia, it is only necessary to perform the first step in the above-described dosing regimen of the invention. In this case, though the drug solution concentration of the sédative is not particularly limited, an arbitrary concentration may be adopted within a range of, for example, 1 mg/mL to 5 mg/mL. Further, in this case, for the maintenance of general anesthésia, an arbitrary agent for maintaining anesthésia can be used. [0074]
In the invention, in the case where the sédative comprising Compound A or a sait thereof is used only for the purpose of maintaining general anesthésia not for the purpose of inducing and maintaining general anesthésia, it is only necessary to perform the second step in the above-described dosing regimen of the invention. In this case, though the drug solution concentration of the sédative is not particularly limited, for example, it is preferably 1 mg/mL. Further, in this case, for the induction of general anesthésia, an arbitrary agent for inducing anesthésia can be used. [0075] [Toxicity]
As long as the sédative comprising Compound A or a sait thereof as an active ingrédient is used for the induction and/or maintenance of general anesthésia using the dosing regimen disclosed in the invention, side effects thereof are extremely low. For example, in the below-described Examples, the results of clinical trials in 85 cases of patients in total are shown, and hypotension whose causal relationship with methyl
3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate or a sait thereof, which is the active ingrédient, cannot be denied, in other words, which may be caused by the administration of the compound was observed in only 9 cases (10.6%). Further, angialgia was not observed in any of the patients.
[0076]
In this spécification, the expression adverse event and/or side effect is used. The adverse event refers to every unpreferred or unintended sign (including abnormal laboratory examination values), symptom, or pathology occurring while Compound A or a sait thereof is being administered regardless of the presence or absence of the causal relationship with Compound A or a sait thereof. [0077]
Further, the side effect refers to, among the above-described adverse events, an effect which is determined such that its causal relationship with Compound A or a sait thereof cannot be denied in considération of the conditions and past history of a test subject, a concomitant agent, a time relationship with the onset of the event, etc. [0078]
[Application to Pharmaceutical Product]
In the case where the sédative comprising Compound A or a sait thereof as an active ingrédient is used for the induction and/or maintenance of general anesthésia using the dosing regimen disclosed in the invention, any patient can receive the administration of the sédative as long as the patient needs general anesthésia, preferably the patient is going to undergo surgery using general anesthésia regardless of the type of surgery or the duration of surgery. For example, the 85 cases of patients in total who participated in the clinical trials, the results of which are shown in the below-described Examples, underwent surgery using general anesthésia for a different site such as the anterior neck, left forehead, lower jaw, chest, abdomen, utérus, extremities, trunk and right upper extremity, crotch, urinary tract, bladder, right hip joint, right lower extremity, etc., and it is demonstrated that the induction and/or maintenance of general anesthésia using the dosing regimen disclosed in the invention can be applied to any patient. [0079]
By using the sédative comprising Compound A or a sait thereof as an active ingrédient for the induction of general anesthésia or the induction and maintenance of general anesthésia using the dosing regimen disclosed in the invention, anesthésia can be induced rapidly in a patient who needs general 65
I anesthésia according to the procedure of the first step. Preferably, the loss of consciousness can be caused in a patient within about 180 seconds, more preferably within about 120 seconds, further more preferably within about 90 seconds, still further more preferably within about 70 seconds, and particularly preferably within about 60 seconds after the intravenous administration of Compound A or a sait thereof is started.
[0080]
By using the sédative comprising Compound A or a sait thereof as an active ingrédient for the maintenance of general anesthésia or the induction and maintenance of general anesthésia using the dosing regimen disclosed in the invention, stable maintenance of anesthésia can be ensured in a patient under general anesthésia according to the procedure of the second step of the dosing regimen. Specifically, it is not necessary to perform a salvage treatment for the excessive anesthésia in the patient under general anesthésia, and further, intraoperative awakening due to light anesthésia is not caused in the patient under general anesthésia. [0081]
By using the sédative comprising Compound A or a sait thereof as an active ingrédient for the maintenance of general anesthésia or the induction and maintenance of general anesthésia using the dosing regimen disclosed in the invention, , Ψ » after stopping the administration thereof, rapid recovery from anesthésia can be caused in a patient under general anesthésia. In the below-described Examples 2 and 4, an average time until the patient opened eyes, an average time until the trachea was extubated, an average time until the patient stated the date of birth, and a time until it was determined that the patient can leave the surgery room after stopping the administration are shown, and whether the patient is an elderly adult or not, the average time until the patient opened eyes was about 15 minutes or less and the average time until it was determined that the patient can leave the surgery room was about 30 minutes or less, and therefore, it is apparent that rapid recovery from anesthésia can be obtained.
[0082]
The usefulness of dosing regimen of the invention can also be confirmed by, for example, the following test (Test Example X) in addition to the four tests described in the Examples. By using the three indexes of presence or absence of intraoperative awakening/memory, presence or absence of salvage treatment against the sédative effect, and presence or absence of body motion as obtained as a resuit of such tests, the function as general anesthetic can be evaluated compositely. Further, in addition to the above, as needed, the évaluation of usefulness regarding, for example, a time from the start of the administration of Compound B until loss of consciousness, a BIS value at each point of time, a time until the patient opens eyes after the administration of Compound B is stopped, a time until extubation after the administration of Compound B is stopped, a time until the patient States the date of birth after the administration of Compound B is stopped, a time until it is determined that the patient can leave the surgery room after the administration of Compound B is stopped, or controllability of the depth of anesthésia, and évaluation of items of safety regarding, for example, adverse events, side effects, general laboratory examination (for example, hematological examination, hematobiochemical examination, or urinalysis), physical examination (for example, blood pressure/heart rate (recumbent position), respiratory rate, body température (for example, deep part température or arterial oxygen saturation) , electrocardiography (for example, resting 12-lead electrocardiogram or monitor electrocardiogram) , a proportion of the point of time when the systolic blood pressure is 80 mmHg or more and less than 150 mmHg to the total points of time, the number of times of using a vasopressor, observation of the administration site with an investigational new drug, or observation of the excited state, may be carried out. [0083]
Test Example X (Induction and maintenance of general anesthésia in patients at the âge of 20 or older using Compound B)
A multi-center, randomized, parallel-group, controlled study is carried out for 325 surgery patients at the âge of 20 or older to undergo general anesthésia using propofol as a control in combination with a narcotic analgésie. [0084] [Method]
The study is carried out by allocating 325 test subjects to three groups (Group XI, Group X2, and Group X3) according to the description in the following Table 1. [Table 1]
Table 1
Group XI X2 X3
Dosing rate of Compound B (mg/kg/h) 6 12
Dose of propofol (mg/kg) 2.0-2.5 ( slowly)
Test subjects 130 130 65
[0085]
After the test subjects are subjected to an analgésie treatment by intravenous continuous administration of remifentanil hydrochloride (see the following a-1), the intravenous administration of Compound B or propofol (see the following a-2) is started. After loss of consciousness in the test subjects is confirmed, rocuronium bromide is intravenously administered (see the following a-3), and the dosing rate of Compound B or propofol is also changed (see the following a-4). After confirming that a sufficient muscle relaxing effect is obtained, endotrachéal intubation is performed. During the surgery, the intravenous continuous administration of remifentanil hydrochloride (see the following a-5) and the intravenous continuous administration of Compound B or propofol are continued, and rocuronium bromide is administered (see the following a-6) , as needed. After completion of the surgery, the intravenous continuous administration of remifentanil hydrochloride and Compound B or propofol is stopped. [0 08 6] (a-1)
The dosing rate of remifentanil hydrochloride is set to 0.25 to 0.5 pg/kg/min. Incidentally, it is to be noted that the dose of remifentanil hydrochloride can be appropriately increased or decreased according to the âge or general conditions of the test subject. [0087] (a-2)
The dosing rate of Compound B is set according to the description in the above Table 1. Incidentally, it is to be noted that in the Group X3, propofol which is the control is used in place of Compound B and is slowly administered at a dose of 2.0 to 2.5 mg/kg.
[0088] (a-3)
The dose of rocuronium bromide is set to 0.6 to 0.9 mg/kg. Incidentally, it is to be noted that the dose of rocuronium bromide can be appropriately increased or decreased according to the âge or general conditions of the test subject. [0089] (a-4)
The dosing rate of Compound B is set to 1 mg/kg/h. Incidentally, it is to be noted that the dosing rate of Compound B can be appropriately increased or decreased within a range of 2 mg/kg/h at maximum while observing the general conditions of the test subject until completion of the surgery. Further, the dosing rate of propofol is set to 4 to 10 mg/kg/h, and it is to be noted that the dosing rate of propofol can also be appropriately increased or decreased while observing the general conditions of the test subject until completion of the surgery. [0090] (a-5)
The dosing rate of remifentanil hydrochloride is set to 0.25 qg/kg/min. Incidentally, it is to be noted that the dosing rate of remifentanil hydrochloride can be appropriately increased or decreased within a range of 2.0 pg/kg/min at maximum while observing the general conditions of the test subject. It is to be noted that during light anesthésia, the single intravenous administration of remifentanil hydrochloride can be additionally performed at a dose of 0.5 to 1.0 pg/kg. [0091] (a-6)
It is to be noted that during the surgery, rocuronium bromide can be intravenously administered at a dose of 0.1 to 0.2 mg/kg, or can be intravenously and continuously administered at a dosing rate of 7 pg/kg/min which is used as a standard, as needed. [0092]
The dosing regimen of the invention, the usefulness of which has been confirmed by carrying out the studies described in the Examples or the above-described study, may be described by providing appropriate items regarding efficacy/effect, dosage and administration, and the like in at least one of an instruction, a manual, an appendix, and a product label (including one corresponding to a label or labeling or labelling in U.S.A.) to be attached to, for example, a pharmaceutical composition comprising as an active ingrédient, the compound or a sait thereof (preferably Compound B) . Though such examples are not limited to this, examples thereof include the description of the following Case 1 or 2. [0093] (Case 1) [Efficacy/Effect] Induction and Maintenance of general anesthésia [0094] [Dosage/Administrâtion] (1) Induction
In general, remimazolam is intravenously administered at a rate of 6 mg/kg/h to an adult patient while observing the general conditions of the patient until sleeping is obtained. (2) Maintenance
The dosing rate is adjusted so as to obtain an adéquate depth of anesthésia while observing the general conditions of a patient. In general, for the adult patient, the adéquate depth of anesthésia is obtained at a dosing rate of remimazolam of 0.4 to 1 mg/kg/h.
Further, an analgésie (for example, a narcotic analgésie or a local analgésie) is to be used in combination. [0095] (Case 2) [Efficacy/Effect] Induction and Maintenance of general anesthésia [0096] [Dosâge/Administrâtion] (1) Induction
In general, remimazolam is intravenously administered at a rate of 12 mg/kg/h to an adult patient while observing the general conditions of the patient until sleeping is obtained.
(2) Maintenance
The dosing rate is adjusted so as to obtain an adéquate depth of anesthésia while observing the general conditions of a patient. In general, for the adult patient, the adéquate depth of anesthésia is obtained at a dosing rate of remimazolam of 0.4 to 1 mg/kg/h.
Further, an analgésie (for example, a narcotic analgésie or a local analgésie) is to be used in combination. [0097]
In the invention, the product includes (1) a pharmaceutical composition comprising, as an active ingrédient, Compound A or a sait thereof and (2) a container containing the composition, and in addition thereto, (3) at least one of an instruction, a manual, an appendix, a product label, and the like (including one corresponding to a label or labeling or labelling in U.S.A.), indicating that the composition can be used in combination with an appropriate concomitant drug (preferably a narcotic analgésie and/or a muscle relaxant, or the like) for the induction and maintenance of general anesthésia, as needed. [0098]
Here, the appendix means a package insert (also called statement of virtues) as referred to under the Pharmaceutical Affairs Law in Japan; Summary of Product Characteristics (SPC or SmPC) as referred to under the instructions in the European Union (EU); US Package Insert (USPI) as referred to under the Code of Fédéral Régulations in U.S.A.; or official documents corresponding to the foregoing documents in other countries, the official documents describing the items necessary for adéquate use of medicines and being attached to the medicines.
[0099]
The items described in these documents are stipulated in detail in, for example, so far as the package insert of Japan is concerned, Articles 52, 54, and 68-4, etc. of the
Pharmaceutical Affairs Law (see Notification Nos. 606 and 607 of the Pharmaceutical Affairs Bureau, Ministry of Health and Welf are dated April 2 5, 1997, and/or the related notifications, etc., as needed); so far as the Summary of Product Characteristics of the European Union is concerned, Directive 2001/83/EC Article 11, etc. (see A guideline on SmPC and/or the related guidelines, etc., as needed); and so far as the US Package Insert of U.S.A. is concerned, 21 CFR 201.100, etc. (see 21 CFR 201.57 and/or the related code of fédéral régulations, etc., as needed). However, in general, information regarding indication, administration, dosage, dosing regimen, warning, and/or contraindication, etc. is
I included.
[0100]
Incidentally, in U.S.A., in addition to the above-described US Package Insert, it is stipulated in 21 CFR 201 Subpart B that a part or the whole of the contents be described in the US Package Insert as a label or labeling or labelling. Here, the label means one expressed directly on the container, and the labeling or labelling means a concept including, in addition to the label, a print on the package or a printed matter annexed to the product, etc. [0101]
In the invention, the container means one enclosing immediately Compound A or a sait thereof as the active ingrédient, and it may also be called an intermediate container, an immédiate wrapper, or an inner seals, etc. In general, examples of the container which is used include a can, a bottle, a box, an ampoule, a vial, a tube, a unit dose container for eyedrop medicines, paper, a cloth, a plastic film, a plastic bag, an SP sheet, a PTP sheet, a plastic container, and the like. However, in the invention, a container for injection, such as an ampoule or a vial, is preferred. [0102]
The container enclosing a pharmaceutical composition is generally packaged by an outer container or an outer wrapper in a combined state with at least one of an instruction, a manual, an appendix, a product label, and the like (including one corresponding to a label or labeling or labelling in U.S.A.), as described above, and it may be circulated in the market.
[0103]
Further, the invention also discloses a method for advertising a pharmaceutical composition comprising, as an active ingrédient, Compound A or a sait thereof, wherein the use of the composition for the induction and/or maintenance of general anesthésia is promoted to a target viewer. [0104]
In the above-described method, during the induction and/or maintenance of general anesthésia, the information indicating usefulness for using the pharmaceutical composition comprising the compound of the invention, particularly an advantage in the health aspect is publicly distributed. The distribution of such information is performed via an appropriate advertising medium in addition to communication by languages. Here, as the advertising medium, newspaper, magazine, télévision, radio, video, pamphlet, leaflet, poster, social networking system, electronic mail, electronic signboard, digital signage, internet advertising (for example, homepage/website or banner advertising), outdoor advertising (for example, posterboard, néon sign, or large-sized vision), transportation advertising (for example, advertising poster in train, bus, taxi, etc.,
I advertising on window, gakumen kokoku (on—frame advertising), or station attach advertising), movie/slide advertising (for example, screen advertising in theater), POP advertising (for example, window advertisement or point-of-purchasing advertising), direct advertising (for example, direct mail, newspaper insert advertising, or leaflet advertising), specialty advertising (for example, novelty advertising of calender, ballpoint pen, etc.), other advertisings (for example, skywriting or bench advertising), or the like may be arbitrarily adopted. It is easy for one skilled in the art to produce such advertising media.
[0105]
Ail of the technical or scientific terminologies and abbreviates used in this spécification hâve the same meanings as those ordinarily understood by one skilled in the art who belongs to the field of the invention, unless otherwise indicated.
[0106]
This application claims priority to Japanese Patent Application No. 2012-192081 filed on August 31, 2012, the entire contents of which are incorporated by reference herein.
The entire contents of ail of the patent documents and the non-patent documents or the references explicitly cited in this spécification are incorporated herein by reference as part of this spécification.
1 :. i
[Exampies] [0107]
Hereinafter, the invention will be described in detail with reference to Examples and Biological Examples, however, the invention is not limited thereto.
In the following studies, as Compound B to be administered, a pharmaceutical préparation described in the below-mentioned Préparation Example was used. [0108]
Further, in the following studies, in order to confirm safety, adverse events and side effects were observed, and also general laboratory examination (hematological examination, hematobiochemical examination and urinalysis), physical examination (blood pressure, puise rate, respiratory rate, body température, blood oxygen saturation level and end-tidal carbon dioxide level) , electrocardiography, etc. were carried out according to the procedures commonly used by those skilled in the art. [0109]
The term BMI described in tables dénotés body mass index and is a physique index which represents the degree of obesity in humans and is calculated from the relationship between body weight and body height. BMI can be calculated according to the formula : {BMI = body weight (kg) / (body height (m))2}.
[0110]
Example 1 (Induction of general anesthésia in non-elderly adults using Compound B)
A non-blind study was carried out for 25 surgery patients at the âge of 20 or older and younger than 65 to undergo general anesthésia using Compound B in combination with a narcotic analgésie. [OUI] [Method]
The study was carried out by allocating 25 test subjects to four groups (Group Al, Group A2, Group A3 and Group A4) according to the description in the following Table 2. [Table 2] Table 2
Group A1 A2 A3 A4
Dosing rate of Compound B (mg/kg/h) 6 12 21 30
Number of test subjects (patients) 5 10 5 5
Gender of test subjects Male 2 1 4 3
(patients) Female 3 9 1 2
[0112]
At 5 minutes before the start of the administration of Compound B, the intravenous continuous administration of remifentanil hydrochloride (see the following 1-1) was started, and after 5 minutes passed, the intravenous continuous administration of Compound B (see the following 1-2) was started. After loss of consciousness in the test subjects was confirmed, rocuronium bromide was intravenously administered (see the following 1-3) and also the dosing rate of Compound B was changed (see the following 1-4) . After confirming that the TOF ratio reached 0 by using a TOF Watch, endotrachéal intubation was performed, and the intravenous continuous administration of remifentanil hydrochloride and Compound B was stopped. After endotrachéal intubation, sevoflurane was used for the maintenance of general anesthésia during the surgery.
[0113] (1-1)
The dosing rate of remifentanil hydrochloride was set to 0.25 pg/kg/min. (1-2)
The dosing rate of Compound B was set according to the description in the above Table 2.
(1-3)
The dose of rocuronium bromide was set to 0.6 mg/kg. The dose of rocuronium bromide can be increased or decreased appropriately according to the âge or symptoms of the test subject, however, the upper limit thereof was set to 0.9 mg/kg. [0114] (1-4)
The dosing rate of Compound B was set to 1 mg/kg/h. The dosing rate of Compound B can be increased or decreased appropriately according to the conditions of the test subject, and it was determined that when a BIS value exceeds 53 or signs of awakening (body motion, change in blood pressure or puise rate, lacrimation, sweating, etc.) are observed, the dosing rate of Compound B can be increased to a maximum of 2.5 mg/kg/h, and when it is confirmed that a BIS value is 53 or less and also signs of awakening are not observed, the dosing rate of Compound B can be carefully decreased.
[0115] [Results]
The results obtained in Example 1 are shown in the following Table 3 (the ± numerical value in each parenthesis additionally shown for the average âge, average body height, average body weight and BMI represents a standard error, and as for the time until loss of consciousness, an average value and a range of actual values (in parenthesis) of the times in the patients (25 patients) in compliance with the study protocol are shown). [0116]
In the step for the induction of general anesthésia, by intravenously and continuously administering Compound B to the patients at a dosing rate of 6, 12, 21 or 30 mg/kg/h, the patients lost consciousness in 108.0 sec, 70.3 sec, 65.8 sec or 65.4 sec (each of which is an average value), respectively. The completion rate of endotrachéal intubation was 100%. Only one patient in Group A2 developed hypotension as a side effect, which shows that the incidence of hypotension was not increased as the dosing rate of Compound B was increased. Further, other side effects to be concerned or abnormal laboratory data were not observed.
[0117]
[Table 3]
Table 3
Group A1 A2 A3 A4
Average âge (years old) 53.2 (±9-5) 49.3 (±14.5) 51.4 (±14.0) 50.4 (±10.1)
Average body height (cm) 161.7 (±1.69) 156.9 (±6.73) 163.4 (±5.22) 161.7 (±13.11)
Average body weight (kg) 59.4 (±3.40) 56.3 (±10.30) 71.5 (±22.67) 61.5 (±13.20)
BMI 22.75 (±1.52) 22.88 (±4.04) 27.02 (±9.65) 23.28 (±2.77)
Time until loss of consciousness (sec) 108.0 (97-117) 70.3 (53-84) 65.8 (61-73) 65.4 (54-83)
Number of test subjects who developed hypotension (patients) Adverse event 0 3 3 1
Side effect 0 1 0 0
[0118]
Example 2 (Induction and maintenance of general anesthésia in non-elderly adults using Compound B)
A non-blind study was carried out for 30 surgery patients at the âge of 20 or older and younger than 65 to undergo general anesthésia using Compound B in combination with a narcotic analgésie. [0119] [Method]
The study was carried out by allocating ail of the 30 test subjects to one group (Group B).
At 5 minutes before the start of the administration of Compound B, the intravenous continuous administration of remifentanil hydrochloride (see the following 2 — 1) was started, and after 5 minutes passed, the intravenous continuous administration of Compound B (see the following 2-2) was started. After loss of consciousness in the test subjects was confirmed, rocuronium bromide was intravenously administered (see the following 2-3) and also the dosing rate of Compound B was changed (see the following 2-4) . After confirming that the TOF ratio reached 0 by using a TOF Watch, endotrachéal intubation was performed. During the surgery, the intravenous continuous administration of remifentanil hydrochloride (see the following 2-5) and the intravenous continuous administration of Compound B (see the following 2-6) were continued, and rocuronium bromide was administered (see the following 2-7) as needed. After completion of the surgery, it was confirmed that the TOF ratio increased to 0.9 or higher by using a TOF Watch, and then, the intravenous continuous administration of remifentanil hydrochloride and Compound B was stopped. [0120] (2-1)
The dosing rate of remifentanil hydrochloride was set to 0.25 pg/kg/min. (2-2)
The dosing rate of Compound B was set to 12 mg/kg/h.
(2-3)
The dose of rocuronium bromide was set to 0.6 mg/kg. The dose of rocuronium bromide can be increased or decreased appropriately according to the âge or symptoms of the test subject, however, the upper limit thereof was set to 0.9mg/kg. [0121] (2-4)
The dosing rate of Compound B was set to 1 mg/kg/h. The dosing rate of Compound B can be increased or decreased appropriately according to the conditions of the test subject, and it was determined that when a BIS value exceeds 53 or signs of awakening (body motion, change in blood pressure or puise rate, lacrimation, sweating, etc.) are observed, the dosing rate of Compound B can be increased to a maximum of 2.5 mg/kg/h, and when it is confirmed that a BIS value is 53 or less and also signs of awakening are not observed, the dosing rate of Compound B can be carefully decreased. [0122] (2-5)
The dosing rate of remifentanil hydrochloride was set to 0.25 pg/kg/min. It was determined that the dosing rate of remifentanil hydrochloride can be increased by 25% to 100% (with the proviso that the dosing rate does not exceed a maximum of 2.0 pg/kg/min) at intervals of from 2 to 5 minutes, or can be decreased by 25% to 50% while observing the general conditions of the test subject. It was also determined that during light anesthésia, the single intravenous administration of remifentanil hydrochloride can be additionally performed at a dose of from 0.5 to 1.0 pg/kg at intervals of from 2 to 5 minutes.
[0123] (2-6)
The dosing rate of Compound B was set to 1 mg/kg/h. The dosing rate of Compound B can be increased or decreased appropriately according to the conditions of the test subject, and it was determined that when a BIS value exceeds 53 or signs of awakening (body motion, change in blood pressure or puise rate, lacrimation, sweating, etc.) are observed, the dosing rate of Compound B can be increased to a maximum of 2.5 mg/kg/h, and when it is confirmed that a BIS value is 53 or less and also signs of awakening are not observed, the dosing rate of Compound B can be carefully decreased. [0124] (2-7)
It was determined that rocuronium bromide can be intravenously administered at a dose of from 0.1 to 0.2 mg/kg or intravenously and continuously administered at a dosing rate of 7 pg/kg/min which is used as a standard. [0125]
[Results]
The results obtained in Example 2 are shown in the following Table 4 (the ± numerical value in each parenthesis additionally shown for the average âge, average body height, average body weight and BMI represents a standard error, and as for the time until loss of consciousness, an average value and a range of actual values (in parenthesis) of the times in the patients (25 patients) in compliance with the study protocol are shown). [0126]
In the step for the induction of general anesthésia, by intravenously and continuously administering Compound B to the patients at a dosing rate of 12 mg/kg/h, the patients lost consciousness in 72.8 sec (which is an average value). The completion rate of endotrachéal intubation was 100%. [0127]
In the step for the maintenance of general anesthésia, the dosing rate of Compound B was set to 1 mg/kg/h at the beginning, and thereafter, the dosing rate of Compound B was appropriately adjusted while observing the conditions of the test subject such as a BIS value, whereby the surgery could be completed without performing a salvage treatment for sédation in ail of the test subjects. Further, signs of awakening during the surgery were not observed and it was confirmed that the test subjects had no recollection during anesthésia .
The number of patients who developed hypotension as a side effect was three, which accounts for 10% of the test subjects in Group B. Further, other side effects to be concerned or abnormal laboratory data were not observed. [0128]
The average of the dosing periods of Compound B of 30 cases in the step for the maintenance of general anesthésia was 167.0 ± 81.3 min (the shortest dosing period: 4.7 min and the longest dosing period: 329.7 min). The maintenance of general anesthésia using Compound B was safely and effectively performed throughout these dosing periods.
[0129]
[Table 4]
Table 4
Group B
Average âge (years old) 45.8 (±11.4)
Average body height (cm) 157.3 (±7.69)
Average body weight (kg) 55.9 (±10.58)
BMI 22.64 (±4.37)
Time until loss of consciousness (sec) 72.8 (48-120)
Number of test subjects who developed hypotension (patients) Adverse event 3
Side effect 3
[0130]
In order to confirm the rapidity of recovery from anesthésia after stopping the administration, for the patients ( 24 patients) in compliance with the study protocol, a time until the patient opened eyes, a time until the trachea was extubated, a time until the patient stated the date of birth, and a time until it was determined that the patient can leave the surgery room, after stopping the administration of Compound B were measured, and the following results were obtained.
• Average time until the patient opened eyes (min): 13.9 • Average time until the trachea was extubated (min): 16.4 • Average time until the patient stated the date of birth (min) : 21.5 • Average time until the patient were allowed to leave the surgery room (min): 25.5
These results showed that Compound B allows rapid recovery from anesthésia after stopping the administration of Compound B.
[0131]
Example 3 (Induction of general anesthésia in elderly adults using Compound B)
A non-blind study was carried out for 20 surgery patients at the âge of 65 or older to undergo general anesthésia using Compound B in combination with a narcotic analgésie.
[0132]
[Method]
The study was carried out by allocating 20 test subjects to three groups (Group Cl, Group C2 and Group C3) according to the description in the following Table 5.
[Table 5]
Table 5
Group C1 C2 C3
Dosing rate of Compound B (mg/kg/h) 4 8 12
Number of test subjects (patients) 10 5 5
Gender of test subjects __________(patients)__________ Male 6 3 3
Female 4 2 2
[0133]
At 5 minutes before the start of the administration of Compound B, the intravenous continuous administration of remifentanil hydrochloride (see the following 3-1) was started, and after 5 minutes passed, the intravenous continuous administration of Compound B (see the following 3-2) was started. After loss of consciousness in the test subjects was confirmed, rocuronium bromide was intravenously administered (see the following 3-3) and also the dosing rate of Compound B was changed (see the following 3-4). After confirming that the TOF ratio reached 0 by using a TOF Watch, endotrachéal intubation was performed, and the intravenous continuous administration of remifentanil hydrochloride and Compound B was stopped. After endotrachéal intubation, sevoflurane was used for the maintenance of general anesthésia during the surgery. [0134] (3-1)
The dosing rate of remifentanil hydrochloride was set to 0.25 pg/kg/min.
(3-2)
The dosing rate of Compound B was set according to the description in the above Table 5. (3-3)
The dose of rocuronium bromide was set to 0.6 mg/kg. The dose of rocuronium bromide can be increased or decreased appropriately according to the âge or symptoms of the test subject, however, the upper limit thereof was set to 0 . 9 mg/kg. [0135] (3-4)
The dosing rate of Compound B was set to 1 mg/kg/h. The dosing rate of Compound B can be increased or decreased appropriately according to the conditions of the test subject, and it was determined that when a BIS value exceeds 53 or signs of awakening (body motion, change in blood pressure or puise rate, lacrimation, sweating, etc.) are observed, the dosing rate of Compound B can be increased to a maximum of 2.5 mg/kg/h, and when it is confirmed that a BIS value is 53 or less and also signs of awakening are not observed, the dosing rate of Compound B can be carefully decreased. [0136] [Results]
The results obtained in Example 3 are shown in the following Table 6 (the ± numerical value in each parenthesis additionally shown for the average âge, average body height, average body weight and BMI represents a standard error, and as for the time until loss of consciousness, an average value and a range of actual values (in parenthesis) of the times in the patients (Group Cl: 9 patients, Group C2: 4 patients and Group C3: 5 patients) in compliance with the study protocol are shown).
[0137]
In the step for the induction of general anesthésia, by intravenously and continuously administering Compound B to the patients at a dosing rate of 4, 8 or 12 mg/kg/h, the patients lost consciousness in 115.2 sec, 72.5 sec or 57.6 sec (each of which is an average value), respectively. The completion rate of endotrachéal intubation was 100%. The number of patients who developed hypotension as a side effect was one in each Group, which shows that the incidence of hypotension was not increased as the dosing rate of Compound B was increased. Further, other side effects to be concerne! or abnormal laboratory data were not observed. [0138] [Table 6]
Table 6
Group C1 C2 C3
Average âge (years old) 72.9 (±5.4) 75.0 (±4.2) 74.2 (±5-9)
Average body height (cm) 157.9 (±8.00) 153.5 (±6.33) 152.8 (±10.61)
Average body weight (kg) 57.2 (±11.77) 58.3 (±6.93) 57.9 (±5.43)
BMI 22.78 (±3.35) 24.66 (±1.14) 25.05 (±4.02)
Time until loss of consciousness (sec) 115.2 (67-165) 72.5 (58-87) 57.6 (43-68)
Number of test subjects who developed hypotension (patients) Adverse event 2 3 2
Side effect 1 1 1
[0139]
Example 4 (Induction and maintenance of general anesthésia in elderly adults using Compound B)
A non-blind study was carried out for 10 surgery patients at the âge of 65 or older to undergo general anesthésia using Compound B in combination with a narcotic analgésie. [0140] [Method]
The study was carried out by allocating ail of the 10 test subjects to one group (Group D).
At 5 minutes before the start of the administration of Compound B, the intravenous continuons administration of remifentanil hydrochloride (see the following 4-1) was started, and after 5 minutes passed, the intravenous continuous administration of Compound B (see the following 4-2) was started. After loss of consciousness in the test subjects was confirmed, rocuronium bromide was intravenously administered (see the following 4-3) and also the dosing rate of Compound B was changed (see the following 4-4). After confirming that the TOF ratio reached 0 by using a TOF Watch, endotrachéal intubation was performed. During the surgery, the intravenous continuons administration of remifentanil hydrochloride (see the following 4-5) and the intravenous continuons administration of Compound B (see the following 4-6) were continued, and rocuronium bromide was administered (see the following 4-7) as needed. After completion of the surgery, it was confirmed that the TOF ratio increased to 0.9 or higher by using a TOF Watch, and then, the intravenous continuons administration of remifentanil hydrochloride and Compound B was stopped.
[0141] (4-1)
The dosing rate of remifentanil hydrochloride was set to 0.25 pg/kg/min.
(4-2)
The dosing rate of Compound B was set to 4 mg/kg/h. (4-3)
The dose of rocuronium bromide was set to 0.6 mg/kg. The dose of rocuronium bromide can be increased or decreased appropriately according to the âge or symptoms of the test subject, however, the upper limit thereof was set to 0 . 9 mg/kg. [0142] (4-4)
The dosing rate of Compound B was set to 1 mg/kg/h. The dosing rate of Compound B can be increased or decreased appropriately according to the conditions of the test subject, and it was determined that when a BIS value exceeds 53 or signs of awakening (body motion, change in blood pressure or puise rate, lacrimation, sweating, etc.) are observed, the dosing rate of Compound B can be increased to a maximum of 2.5 mg/kg/h, and when it is confirmed that a BIS value is 53 or less and also signs of awakening are not observed, the dosing rate of Compound B can be carefully decreased. [0143] (4-5)
The dosing rate of remifentanil hydrochloride was set to 0.25 pg/kg/min. It was determined that the dosing rate of remifentanil hydrochloride can be increased by 25% to 100% (with the proviso that the dosing rate does not exceed a maximum of 2.0 pg/kg/min) at intervals of from 2 to 5 minutes, or can be decreased by 25% to 50% while observing the general conditions of the test subject. It was also determined that during light anesthésia, the single intravenous administration of remifentanil hydrochloride can be additionally performed at a dose of from 0.5 to 1.0 pg/kg at intervals of from 2 to 5 minutes. [0144] i
< 4 - 6 )
The dosing rate of Compound B was set to 1 mg/kg/h. The dosing rate of Compound B can be increased or decreased appropriately according to the conditions of the test subject, and it was determined that when a BIS value exceeds 53 or signs of awakening (body motion, change in blood pressure or puise rate, lacrimation, sweating, etc.) are observed, the dosing rate of Compound B can be increased to a maximum of 2.5 mg/kg/h, and when it is confirmed that a BIS value is 53 or less and also signs of awakening are not observed, the dosing rate of Compound B can be carefully decreased. [0145] (4-7)
It was determined that rocuronium bromide can be intravenously administered at a dose of from 0.1 to 0.2 mg/kg or intravenously and continuously administered at a dosing rate of 7 pg/kg/min which is used as a standard. [0146] [Results]
The results obtained in Example 4 are shown in the following Table 7 (the ± numerical value in each parenthesis additionally shown for the average âge, average body height, average body weight and BMI represents a standard error, and as for the time until loss of consciousness, an average value and a range of actual values (in parenthesis) of the times in the patients (7 patients) in compliance with the study protocol are shown).
[0147]
In the step for the induction of general anesthésia, by intravenously and continuously administering Compound B to the patients at a dosing rate of 4 mg/kg/h, the patients lost consciousness in 100.3 sec (which is an average value). The completion rate of endotrachéal intubation was 100%. [0148]
In the step for the maintenance of general anesthésia, the dosing rate of Compound B was set to 1 mg/kg/h at the beginning, and thereafter, the dosing rate of Compound B was appropriately adjusted while observing the conditions of the test subject such as a BIS value, whereby the surgery could be completed without performing a salvage treatment for sédation in ail of the test subjects. Further, signs of awakening during the surgery were not observed and it was confirmed that the test subjects had no recollection during anesthésia.
The number of patients who developed hypotension as a side effect was two, which accounts for 20% of the test subjects in Group D. Further, other side effects to be concerned or abnormal laboratory data were not observed. [0149]
The average of the dosing periods of Compound B of 10 cases in the step for the maintenance of general anesthésia was 229.6 ± 151.3 min (the shortest dosing period: 57.0 min and the longest dosing period: 621.7 min). The maintenance of general anesthésia using Compound B was safely and effectively performed throughout these dosing periods.
[0150]
[Table 7]
Table 7
Group D
Average âge (years old) 75.1 (±7.4)
Average body height (cm) 153.4 (±10.98)
Average body weight (kg) 56.8 (±8.52)
BMI 24.10 (±2.48)
Time until loss of consciousness (sec) 100.3 (70-135)
Number of test subjects who developed hypotension (patients) Adverse event 3
Side effect 2
In order to confirm the rapidity of recovery from anesthésia after stopping the administration, for the patients (7 patients) in compliance with the study protocol, a time until the patient opened eyes, a time until the trachea was extubated, a time until the patient stated the date of birth, and a time until it was determined that the patient can leave the surgery room, after stopping the administration of Compound B were measured, and the following results were obtained.
• Average time until the patient opened eyes (min): 10.9 • Average time until the trachea was extubated (min): 13.6 i
!
• Average time until the patient stated the date of birth (min) :
18.5
Average time until the patient were allowed to leave the surgery room (min): 19.1 [0152]
These results showed that Compound B allows rapid recovery from anesthésia after stopping the administration of Compound B.
[0153]
Formulation Example 1 (Injection) (ampoule) Methyl
3-[(4S)-8-bromo-1-methyl- 6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate (89.76 g) , maltose (473 g) , and polysorbate 80 (5.5 g) were mixed in a conventional manner, and a pH adjusting agent and water for injection were added thereto, whereby a solution (5.5 L) at a pH of 3.0 was obtained. The obtained solution was sterilized in a conventional manner and filled in ampoules at 5 mL per ampoule, followed by lyophilization in a conventional manner, whereby 1,000 ampoules each comprising 81.6 mg of methyl 3-[(4S) -8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo [1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate (60 mg in terms of the amount of methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate) were obtained.
[0154]
Formulation Example 2 (Injection) (vial) Methyl
3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[ 1,2-a]
[1,4]benzodiazepin-4-yl]propanoate benzenesulfonate (89.76 g), maltose (473 g), and polysorbate 80 (5.5 g) were mixed in a conventional manner, and a pH adjusting agent and water for injection were added thereto, whereby a solution (5.5 L) at a pH of 3.0 was obtained. The obtained solution was sterilized in a conventional manner and filled in vials at 5 mL per vial, followed by lyophilization in a conventional manner, whereby 1,000 vials each comprising 81.6 mg of methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate (60 mg in terms of the amount of methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate) were obtained. [Industrial Applicability] [0155]
The sédative employing the dosing regimen disclosed in the invention is safe, can rapidly induce general anesthésia in a patient and stably maintain the state of general anesthésia, and allows rapid recovery from anesthésia in a patient after stopping the administration thereof, and therefore is useful for the induction and/or maintenance of general anesthésia.
100

Claims (44)

  1. [Désignation of Document] Claims
    [Claim 1]
    An agent which is a sédative comprising, as an active ingrédient, methyl
    3 - [ (48) -8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate or a sait thereof, wherein the dosing rate of the active ingrédient by intravenous administration is about 0.3 mg to about 40 mg/hour/kg in a patient who needs a treatment with the agent.
  2. [Claim 2]
    The agent according to claim 1, wherein the active ingrédient is methyl
    3-[(48)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate.
  3. [Claim 3]
    The agent according to claim 1 or 2, which is used for the induction and/or maintenance of general anesthésia.
  4. [Claim 4]
    The agent according to claim 3, which is used for (1) the induction and maintenance of general anesthésia, or (2) the induction of general anesthésia.
    101
  5. [Claim 5]
    The agent according to claim 3 or 4, which is used in combination with a narcotic analgésie and optionally a muscle relaxant.
  6. [Claim 6]
    The agent according to claim 4, which induces loss of consciousness in the patient within about 180 seconds after the intravenous administration is started.
  7. [Claim 7]
    The agent according to claim 4, wherein the agent is used for the induction and maintenance of general anesthésia, and the intravenous administration includes a two-step administration process.
  8. [Claim 8]
    The agent according to claim 7, wherein the two-step administration process comprises: a first step for the induction of general anesthésia, in which the dosing rate of the active ingrédient by intravenous administration is about 3 mg to about 40 mg/hour/kg in a patient who needs a treatment with the agent; and a second step for the maintenance of general anesthésia, in which the dosing rate of the active ingrédient by intravenous administration is about 0.3 mg to about 2.5
    102 mg/hour/kg in a patient who needs a treatment with the agent.
  9. [Claim 9]
    The agent according to claim 8, wherein, in the first step, the dosing rate of the active ingrédient by intravenous administration is about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the agent.
  10. [Claim 10]
    The agent according to claim 9, wherein, in the first step, the dosing rate of the active ingrédient by intravenous administration is about 4 mg, about 6 mg, about 8 mg, about 12 mg, about 21 mg, or about 30 mg/hour/kg in a patient who needs a treatment with the agent.
  11. [Claim 11]
    The agent according to claim 10, wherein, in the first step, the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the agent.
  12. [Claim 12]
    The agent according to claim 9, wherein the patient is 20 years old or older and younger than 65 years old.
    103
  13. [Claim 13]
    The agent according to claim 12, wherein, in the first step, the dosing rate of the active ingrédient by intravenous administration is about 6 mg, about 12 mg, about 21 mg, or about 30 mg/hour/kg in a patient who needs a treatment with the agent.
  14. [Claim 14]
    The agent according to claim 13, wherein, in the first step, the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the agent.
  15. [Claim 15]
    The agent according to claim 9, wherein the patient is 65 years old or older.
  16. [Claim 16]
    The agent according to claim 15, wherein, in the first step, the dosing rate of the active ingrédient by intravenous administration is about 4 mg, about 8 mg, or about 12 mg/hour/kg in a patient who needs a treatment with the agent.
  17. [Claim 17]
    The agent according to claim 15, wherein, in the first step, the dosing rate of the active ingrédient by intravenous
    104 administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the agent.
  18. [Claim 18]
    The agent according to claim 8, wherein, in the second step, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 2 mg/hour/kg in a patient who needs a treatment with the agent.
  19. [Claim 19]
    The agent according to claim 18, wherein the patient is 20 years old or older and younger than 65 years old.
  20. [Claim 20]
    The agent according to claim 19, wherein, in the second step, the dosing rate of the active ingrédient by intravenous administration is about 0.8 mg to about 2 mg/hour/kg in a patient who needs a treatment with the agent.
  21. [Claim 21]
    The agent according to claim 19, wherein, in the second step, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the agent.
    105
  22. [Claim 22]
    The agent according to claim 19, wherein, in the second step, the dosing rate of the active ingrédient by intravenous administration is about 1 mg/hour/kg in a patient who needs a treatment with the agent.
  23. [Claim 23]
    The agent according to claim 18, wherein the patient is 65 years old or older.
  24. [Claim 24]
    The agent according to claim 23, wherein, in the second step, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the agent.
  25. [Claim 25]
    The agent according to claim 23, wherein, in the second step, the dosing rate of the active ingrédient by intravenous administration is about 1 mg/hour/kg in a patient who needs a treatment with the agent.
  26. [Claim 26]
    The agent according to claim 4, wherein the agent is used for the induction of general anesthésia, and the intravenous t ' εν
    106 administration includes a one-step administration process.
  27. [Claim 27]
    The agent according to claim 26, wherein the patient is 20 years old or older, and the dosing rate of the active ingrédient by intravenous administration is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the agent.
  28. [Claim 28]
    An agent for inducing loss of consciousness in a patient within about 180 seconds after intravenous administration is started, wherein the agent is a sédative comprising, as an active ingrédient, methyl
    3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, and is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, the intravenous administration of the active ingrédient comprises a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 4 mg to about 30 mg/hour/kg in a patient who needs a treatment with the agent and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4
    107
    I mg to about 2 mg/hour/kg in a patient who needs a treatment with the agent.
  29. [Claim 29]
    The agent according to claim 5 or 28, wherein the narcotic analgésie is remifentanil.
  30. [Claim 30]
    The agent according to claim 5, 28, or 29, wherein the muscle relaxant is rocuronium bromide.
  31. [Claim 31]
    The agent according to claim 1, 28, 29, or 30, wherein the incidence rate of hypotension as a side effect is less than 15% .
  32. [Claim 32]
    A sédative comprising, as an active ingrédient, methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, which is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, wherein the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia,
    108 the dosing rate of the active ingrédient by intravenous administration is about 6 mg/hour/kg in a patient who needs a treatment with the sédative and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the sédative.
  33. [Claim 33]
    A sédative comprising, as an active ingrédient, methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [ 1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, which is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia, wherein the intravenous administration of the active ingrédient includes a two-step administration process, and in a first step for the induction of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 12 mg/hour/kg in a patient who needs a treatment with the sédative and in a second step for the maintenance of general anesthésia, the dosing rate of the active ingrédient by intravenous administration is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the sédative.
    109
  34. [Claim 34]
    A sédative comprising, as an active ingrédient, methyl 3-[ (4 S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, which is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction of general anesthésia, wherein the dosing rate of the active ingrédient by intravenous administration is about 6 mg/hour/kg in a patient who needs a treatment with the sédative.
  35. [Claim 35]
    A sédative comprising, as an active ingrédient, methyl 3-[(4 S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [ 1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, which is used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction of general anesthésia, wherein the dosing rate of the active ingrédient by intravenous administration is about 12 mg/hour/kg in a patient who needs a treatment with the sédative.
  36. [Claim 36]
    A product comprising (1) a pharmaceutical composition comprising, as an active ingrédient, methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, (2) a
    110 container, and (3) an instruction, a manual, an appendix, or a product label, indicating that the active ingrédient can be used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia by intravenous administration in a two-step administration process.
  37. [Claim 37]
    The product according to claim 36, wherein the two-step administration process includes : a first step for the induction of general anesthésia, in which the dosing rate is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the product; and a second step for the maintenance of general anesthésia, in which the dosing rate is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the product.
  38. [Claim 38]
    A product comprising (1) a pharmaceutical composition comprising, as an active ingrédient, methyl 3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate benzenesulfonate, (2) a container, and (3) an instruction, a manual, an appendix, or a product label, indicating that the active ingrédient can be used in combination with a narcotic analgésie and optionally
    111 a muscle relaxant for the induction of general anesthésia by intravenous administration at a dosing rate of about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment of the product.
  39. [Claim 39]
    An instruction, a manual, an appendix, or a product label, indicating that methyl
    3-[ (4 S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [ 1,4]benzodiazepin-4-yl]propanoate benzenesulfonate can be used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction and maintenance of general anesthésia by intravenous administration in a two-step administration process.
  40. [Claim 40]
    The instruction, manual, appendix, or product label according to claim 39, wherein the two-step administration process includes: a first step for the induction of general anesthésia, in which the dosing rate is about 6 mg or about 12 mg/hour/kg in a patient who needs a treatment with the compound; and a second step for the maintenance of general anesthésia, in which the dosing rate is about 0.4 mg to about 1 mg/hour/kg in a patient who needs a treatment with the compound.
    112
  41. [Claim 41]
    An instruction, a manual, an appendix, or a product label, indicating that methyl
    3-[(4S)-8-bromo-l-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [ 1,4]benzodiazepin-4-yl]propanoate benzenesulfonate can be used in combination with a narcotic analgésie and optionally a muscle relaxant for the induction of general anesthésia by intravenous administration at a dosing rate of about 6 mg or about 12 mg mg/hour/kg in a patient who needs a treatment with the compound.
  42. [Claim 42]
    A method which is a sédative method including intravenously administering an effective amount of methyl 3-[ (4 S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate or a sait thereof, which is an active ingrédient, to a patient who needs a treatment with the compound, wherein the dosing rate of the active ingrédient by intravenous administration is about 0.3 mg to about 40 mg/hour/kg in a patient who needs a treatment with the compound.
  43. [Claim 43]
    Methyl
    113
    3 — [ ( 4 S )-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a] [1, 4]benzodiazepin-4-yl]propanoate or a sait thereof for inducing a sédative state, wherein the dosing rate of the compound by intravenous administration is about 0.3 mg to about 40 mg/hour/kg in a patient who needs a treatment with the compound.
  44. [Claim 44]
    Use of methyl
    3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a]
    [1,4]benzodiazepin-4-yl]propanoate or a sait thereof for producing a sédative, wherein the dosing rate of the compound by intravenous administration is about 0.3 mg to about 40 mg/hour/kg in a patient who needs a treatment with the compound.
    114
OA1201500067 2012-08-31 2013-08-30 Method for administering hypnotic/sedative agent. OA20202A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2012-192081 2012-08-31

Publications (1)

Publication Number Publication Date
OA20202A true OA20202A (en) 2022-03-18

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