OA18212A - Use of active compound compositions. - Google Patents
Use of active compound compositions. Download PDFInfo
- Publication number
- OA18212A OA18212A OA1201600482 OA18212A OA 18212 A OA18212 A OA 18212A OA 1201600482 OA1201600482 OA 1201600482 OA 18212 A OA18212 A OA 18212A
- Authority
- OA
- OAPI
- Prior art keywords
- active compound
- compound composition
- mosquitos
- composition according
- resistant
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Abstract
The invention is in the technical field of vector control as well as insecticide-resistant mosquito and bed bug control. The active compound compositions of this invention are used against mosquitos and bed bugs which transmit disease pathogens or which annoy the well-being of humans and animals. The active compound compositions of this invention are in particular useful to overcome target-specific and/or metabolic-specific résistance of mosquitos and bed bugs and are biologically efficient on a variety of surfaces over an extended period of time.
Description
The invention is in the technical field of vector control as well as insecticide-resistant mosquito and bed bug control. The active compound compositions of this invention are used against mosquitos and bed bugs which transmit disease pathogens or which annoy the wcll-bcing of humans and animais. The active compound compositions of this invention are in particular useful to overcome insecticideresistance of mosquitos and bed bugs and are biologically efficient on a variety of surfaces over an extended period of time.
The présent invention relates to new use of active compound compositions which hâve veiy good insecticidal and arachnidial properties and which comprise firstly the known active synthcthic pyrethroid compound deltamethrin and secondly at least one furthei' known insecticidal active compound selected from the group of neonicotinoids.
It is known that the pyrethroid deltamethrin can be employed for controlling animal pests, in particular insects. It has been also disclosed that neonicotinoids such as acetamiprid, clothianidin, dinoteforan, imidacloprid, nitenpyram, thiacloprid and thiamethoxam can be used for controlling unwanted pests. Deltamethrin and neonicotinoids are known and described e.g. in “The Pesticide Manual”, 16th Edition, British Crop Protection Council (deltamethrin, page 241; acetamiprid, page 9; clothianidin, page 225; dinotefuran, page 384; imidacloprid, page 640; nitenpyram, page 809; thiacloprid, page 1102; thiamethoxam, page 854).
W02002/030202A2 relates to a method of preventing damage to the seed and/or shoots and foliage of a plant by a pest which includes treating the seed from which the plant grows with a composition that includes a combination of clothianidin and at least one pyrcthrin or synthetic pyrethroid. W02002/030202A2 does not disclose the use of the combination of neonicotinoids such as clothianidin with deltamethrin for vector control uses in particular against insecticide-resistant pests.
W02004/064522 relates to the use of an arthropod-repelling constituent of the pyrethroid/pyrethrin class combined with an agonist of the nicotine-producing acétylcholine receptors of arthropode, for efficiently repelling arthropods, preferably on animais (for animal health purposes), for a long time. W02002/030202A2 does not disclose the use of the combination of neonicotinoids such as clothianidin with deltamethrin for vector control uses in particular against insecticide-resistant pests.
Frédéric Darriet et al., Pest Manag Sci, 2013, 69:905-910 discloses in table 3 combinations of deltamethrin with piperonyl butoxid (PB O) and various neonicotinoids such as thiamethoxam, nitenpyram, thiacloprid, imidacloprid, clothianidin and acetamiprid. PBO is known as an insecticide synergist that - despite having no insecticidal activity on its own - enhances the potcncy of certain pesticides such as e.g. pyrethroids (sec e.g. table 2; results achieved with the combination of
-2deltamethrin and PBO e.g. the Pa value). As the combination of deltamethrin with PBO is already synergistic it is of no surprise that the addition of a neonicotinoid also leads to synergism (see table 3). However, this publication does not teach that a skilled person in the art can also achievc synergism against résistant strains of Aedes aegypti with the combination of deltamethrin and a neonicotinoid without PBO.
W02005/070210A1 relates to an insecticidal composition comprising a pyrethroid and a second insecticide selected from the group of imidacloprid, nithiazine, thiamethoxam, dinotefuran, nitenpyram, thiacloprid, clothianidin and chlorfenapyr, with significantly improved knock down and mortality characteristics when applied to general household pests. W02005/070210A1 does not disclose that the subject matter of the présent invention. In particular, W02005/070210A1 does not disclose the use of the combination of deltamethrin and a neonicotinoid for vector control. Furthermore, W02005/07021A1 does not disclose the use of the claimed combination for insecticide-resistant mosquito and/or insecticide résistant bed bug control.
Pyrethroids are the only insecticides that hâve obtained WHO recommendation against Malaria vectors for both Indoor Residuals Sprays (1RS) and Long Lasting Insecticidal Mosquito Nets (LLINs), in the form of alpha-cypermethrin, bifenthrin, cyfluthrin, permethrin, deltamethrin, lambda-cyhalothrin and etofenprox. It has been the chemical class of choice in agriculture and public health applications over the last several décades because of its relatively low toxicity to humans, rapid knock-down effect, relative longevity (duration of 3-6 months when used as 1RS), and low cost. However, massive use of pyrethroids in agricultural applications and for vector control led to the development of résistance in major Malaria and Dengue vectors. Strong résistance has e.g. been reported for the pyrethroid deltamethrin (and permethrin) for the Anopheles gambiae Tiassalé (from southem Côte d'ivoire) strain (Constant V.A. Edi et al., Emerging Infectious Diseases; Vol. 18, No. 9, September 2012). Pyrethroid résistance was also reported for permethrin, deltamethrin and lambda-cyhalothrin for the Aedes aegypti Cayman Island strain (Angela F. Harris et al., Am. J. Trop. Med. Hyg., 83(2), 2010) and alphacypermethrin, permethrin and lambda-cyhalothrin for certain Anopheles strains (Win Van Bortel, Malaria Journal, 2008, 7:102).
Bed bug control has (again) become a major task as a resurgence of bed bug infestations has occurred over the last 10 years. In this connection, it has also been reported that these insects hâve developed résistance to pyrethroids such as deltamethrin and beta-eyfluthrin (Zach N. Adclman et al, PloS ONE, October 2011, Vol 6, Issue 10).
Due to the emerging résistance in mosquitoes and bed bugs against certain pyrethroids there is an ongoing need for alternative solutions and strategies in particular for vector and bed bug control management. It is a further objective to avoid the use of piperonyl butoxid (PBO; while achieving
-3 similar/better synergistic effects) as a formulation with PBO is more expensive, more difficult to formulate (as PBO has a complex physico-chemical profile) and in general less rcliable in effect, residuality and storage stability. With the présent invention it has now been surprisingly found that the active compound composition comprising deltaniethrin and secondly at least one further active compound selected from the group of neonicotinoids can be used without PBO for vector control and insecticide-resistant mosquito control as well as for insecticide-resistant bed bug control.
With the présent invention it has now also been found that active compound compositions comprising deltaniethrin (herein referred to as active compounds of group A) and secondly at least one further active compound selected from the group of neonicotinoids (herein referred to as active compounds of group B) are synergistically active without PBO and are suitable for controlling animal pests and in particular to control insecticide-resistant animal pests. Owing to this synergism, markedly lower amounts of active compound may bc used and/or an existing insecticide résistance can be ovcrcomc, that is to say the effect of the mixture exceeds the effect of the individual components. The synergism is in particular surprising in connection with the control of insecticide-resistant mosquitos and/or bed bugs. The synergism is particularly pronounced after an extended period of time (e.g. 11 weeks or more after application of the active compound composition on a surface (particularly on porous and/or alkaline surfaces) and preferably 30 and more preferably 60 weeks after application).
As a conséquence the active compound composition of the invention has a long-term activity. Longerterm protection can reduce the exposure of the user, the inhabitants, the domestic animais and the environment to a minimum, because active substance needs to be applied less frequently.
In a preferred embodiment the active compound composition of the invention comprises preferably as an active compound from group A deltametrin.
The term neonicotinoids according to this invention refers preferably to a compound selected from the group of acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid and thiamethoxam.
In another preferred embodiment the active compound composition of the invention comprises preferably as an active compound from group B clothianidin.
The active compound compositions according to the invention are particularly useful for vector control. Vector control is the prévention of transmission of diseases by vector insects (such as Encephalitis, West Nile Virus, Dengue Fever, Malaria, Rift Valley Fever, Yellow Fever). Vector control methods vary considerably in their applicability, cost and sustainability of their results. In a preferred embodiment of the invention, vector control refers to Malaria and Dengue vector control. Vectors in connection with the prévention of the transmission of diseases arc preferably mosquitoes. A preferred embodiment of the
-4invention therefore relates to the use of the active compound composition of the invention to prevent the transmission of diseases by vector insects preferably by applying the active compound composition to a surface or by spraying it into the air. When the active compound composition is applied on a surface the vector insects are killed or repelled when getting into contact with the surface preferably before they bite human beings and transmit a disease. When the active compound composition is sprayed into the air the vector insects are killed or repelled when getting into direct contact with the active compound composition in the air preferably also before they are able to bite human beings and transmit a disease.
Vector control products include indoor residual spray (1RS), insecticide treated net, long lasting insecticide net, space spray and/or spatial repellents. The active compound composition according to the invention is particularly useful for indoor residual sprays. Indoor residual sprays refer to formulations that are applied on walls and roofs of houses and domestic animal shelters in order to kill adult vectoi' mosquitoes that land and rcst on these surfaces. The primary effect of such sprays is towards curtailing Malaria and Dengue transmission by reducing the life span of vector mosquitoes so that they can no longer transmit the disease from one person to another and reducing the density of the vector mosquitoes.
In another preferred embodiment of the invention the active compound composition of the invention are used to control insecticide-resistant mosquitos and/or insecticide résistant bed bugs. The term “insecticide-resistance” is the tenu used to describe the situation in which the mosquitos or bed bugs are no longer killed by the standard dose of insecticide (they are no longer susceptible to the insecticide) or manage to avoid coming into contact with the insecticide). See 1.2.; p.27; “Global Plan for Insecticide Résistance Management”, WHO 2012). The term vector in the context of this application refers preferably to a mosquito.
As an example, WHO recommended standard dose of deltamethrin for indoor residual treatment against mosquito vectors is 20-25 mg/m2 (http://www.who.int/whopes/Insecticides_IRS_Malaria_09.pdf). WHO recommended standard dose of deltamethrin products treatment of nets for malaria vector control is 15-25 mg/m2 (http://www.who.int/whopes/Insecticides_ITN_Malaria_ok3.pdf). WHO recommended standard dose for space spraying against mosquitoes are described in the publication: http://www.who.int/whopes/Insecticides_for_space_spraying_Jul_2012.pdf. WHO recommended deltamethrin doses for bed bug control are 0.3 - 0.5 g/1 (see Pesticides and their Application, WHO 2006; WHO/CDS/NTD/WHOPES/GCDPP/2006.1).
The term “control” insecticide-resistant mosquitoes and/or bed bugs refers to the possibility to be able to kill and/or repel mosquitoes and/or bed bugs that are insecticide-resistant (in order to avoid the biting of humans and transmission of the vectors to humans).
A further embodiment of the invention relates to the use of the active compound composition according
-5to the invention to control target-sitc- and/or nietabolic-resistant mosquitos and/or bed bugs. Target-site résistance refers to a form of biochemical résistance which occurs when the insecticide compound no longer binds to its target, and metabolic-resistance refers to a form of biochemical résistance which occurs when levels or modified activities of esterases, oxidases, or glutathione S-transferases (GST) prevent an insecticide compound from reaching its site of action.
In another preferred embodiment the active compound compositions of the présent invention are preferably used to control insecticide-resistant mosquitos wherein the insecticide-resistant mosquitos are selected from the group of Anopheles gambiae, preferably the strain RSPH and Anopheles funeslus, preferably the strain FUMOZ-R. In another preferred embodiment the active compound compositions of the présent invention are used to control pyrethroid and/or (preferably and) carbamate- résistant mosquitos, preferably pyrethroid and/or (preferably and) carbamate-resistant Anopheles gambiae and/or Anopheles funeslus mosquitos. More preferably, the active compound compositions of the présent invention are used to control pyrethroid-resistant mosquitos, preferably pyrethroid-resistant Anopheles gambiae and/or Anopheles funestus mosquitos. Another preferred embodiment of the invention relates to the active compound compositions of the présent invention used to control multi-resistant mosquitos.
The invention also relates to the use of an active compound composition according to the invention to control pyrethroid-resistant bed bugs. In a preferred embodiment, the active compound composition of the invention is used to control pyrethroid-resistant bed bugs, wherein the bed bugs hâve a Valine to Leucine mutation (V419L) and/or a Leucine to Isoleucine mutation (L925I) in the voltagc-gatcd sodium channel alpha-subunit gene.
As a further embodiment of the invention, the herein described uses of an active compound composition also includes methods of using the active compound composition for the same purpose.
Anopheles gambiae, the strain RSPH is a multi-resistant mosquito (target-site and metabolic-resistance) that is described in the reagent catalog of the Malaria Research and Reference Reagent Rcsource Center (www.MR4.org; MR4-number: MRA-334).
Anophelesfunestus, strain FUMOZ-R is a metabolic-resistant strain and is described in Hunt et al., Med Vet Entomol. 2005 Sep; 19(3):271-5). In this article it has been reported that Anopheles funestus - as one of the major malaria vector mosquitos in Africa - showed résistance to pyrethroid insecticides (lambdacyhalothrin, deltamethrin, permethrin and carbamate) in South Africa.
Certain Bed bugs are known to be résistant to pyrethroids, wherein the pyrethroid résistance can be ascribed to metabolic résistance such as increased metabolic détoxification by P450s, glutathione transferases, and esterases as well as target-site résistance due to decreased target-site sensitivity of voltagc-gatcd sodium channcls. It has been also reported that a Valine to Lcucinc mutation (V419L)
-6and/or the Leucine to Isoleucine mutation (L925I) in voltage-gated sodium channel alpha-subunit gene is responsible for target-site résistance to deltamethrin in bed bugs (Fan Zhu et al., Archives of Insect Biochemistiy and Physiology, 2010, Vol. 00, No 0, 1-13).
Pyrctliroid and/or (preferably and) carbamatc-rcsistant mosquitos/bcd bugs arc mosquitos/bcd bugs that are résistant to the treatment of pyrethroid insecticides and/or (preferably and) carbamate insecticides. Pyrethroid insecticides are e.g. allethrin, bifenthrin, cyfluthrin, cypermethrin, cyphenothrin, deltamethrin, esfenvalerate, etofenprox, fenpropathrin, fenvalerate, flucythrinate, imiprothrin, lambdacyhalothrin, metofluthrin, permethrin, prallethrin resmethrin, silafluofen, sumithrin, tau-fluvalinate, tefluthrin, tetramethrin, tralomethrin, transfluthrm. Carbamate insecticides are e.g. aldicarb, benfuracarb, carbaryl, carbofuran, carbosulfan, fenobucarb, methiocarb, methomyl, oxarnyl, thiodicarb, triazamate. In a more preferred embodiment the term “Pyrethroid” in the context of “pyrethroid-rcsistant mosquitos/bcd bugs refers to a compound selected from the group of cyfluthrin, cypermethrin, lambdacyhalothrin, deltamethrin and permethrin. In a more preferred embodiment pyrethroid résistance existe in regard to at least one pyrethroid selected from the group of lambda-cyhalothrin, deltamethrin and permethrin.
Multi-resistant mosquitos refers to a mosquitos where scveral different résistance mechanisms are présent simultaneously such as target-site résistance and metabolic résistance. The different résistance mechanisms may combine to provide résistance to multiple classes of products (IRAC publication: “Preventation and Management of Insecticide Résistance in Vectors of Public Health Importance”; second édition; 2011).
In a preferred embodiment, the active compound combinations according to the invention hâve synergistic actions preferably in regard to the above outlined uses. In a more preferred embodiment, the active compound combinations according to the invention show synergistic effects against metabolicresistant mosquitos, preferably against Anopheles funestus, more preferably against the strain FUMOZR. The synergistic effects can be observed, for exemple, when commcrcially available formulations of active compounds of group A and group B or pure technical compounds of group A and group B are applied together. The synergism is particularly pronounced (in particular against metabolic-resistant mosquitos, preferably against Anopheles funestus, more preferably against the strain FUMOZ-R) after the active compound combination has been applied to a certain surface and biological activity is measured after a certain period of time (preferably 11 weeks, more preferably 30 weeks and even more preferably 60 weeks after application). This improved long-term activity / long residuality applies in particular to the treatment of porous and/or alkaline surfaces, such as concrète, render, ashlar/brick, timber (treated and untreated), ccramic, straw or thatch, chalky, limy, gypsiferous, ccmcnt-containing and loamy surfaces. Here, upon application to non-porous surfaces, the activity remains unaffectcd on the whole. A preferred embodiment of the présent invention is therefore the use of an active compound
-7composition according to the présent invention wherein the active compound combination is applied to a surface and wherein the surface-applied active compound combination acts synergistically after a period of at least 11 weeks (preferably 30 and more preferably 60 weeks) without additional active compound composition application on the same surface. This activity ends 2 years, preferably 1.5 years, more preferably 70 weeks and rnost preferably 65 weeks after application of the active compound combination on the corresponding surface.
The active compound compositions according to the invention can be applied to any surface inside buildings or in the open, for example wallpaper, concrète, render, ashlar, timber (treated and untreated), ceramic (glazed and unglazed), straw or thatch, brick (untreated, limewashed, painted), clay minerais (for example terracotta), chalky, limy, gypsiferous, cement-containing and loamy surfaces.
Another embodiment refers to a use of the active compound composition according to the invention wherein the composition is applied only once to a surface for a time period of at least 11 weeks (preferably for a tune period of at least 30 weeks and more preferably for 60 weeks). Thcrefore, the active compound composition of the invention has a residuality of at least 11 weeks (preferably at least 30 weeks and more preferably at least 60 weeks). According to the WH OPES directive “Guidelines for testing mosquito adulticides for indoor residual spraying and treatment of mosquito nets” (see http://www.who.int/whopes/guidelines/en/; see section 2.4.2.1) “residuality” is fulfilled when the mortality is higher or equals 80% after 24 hours.
The synergistic effects permit a réduction of the application rates, a higher efficacy at the same application rate and/or a réduction in the number of individual applications required and/or to ovcrcome an existing insecticide résistance and - as a resuit for the user - an economically and ecologically improved résistant management of mosquitos and bed bugs.
For example, the combinations ofthe active compounds of group A and group B allow the activity to be synergistically enhanced in a manner which far and unexpcctedly excecds the activities which can be achieved with the formulations of the individual active compounds of group A and group B.
The ratio of the compounds of group A employed to the compounds of group B, and the total amount of the mixture to be employed, dépend on the particular mosquito/bed bug strain and the occurrence of the mosquito/bed bugs. The optimal ratios and overall rates used can be determined for each application by test sériés.
The application rate of the active compound combinations according to the invention varies preferably within ranges of between 0.001 and 1000 mg/m2, more preferably, 2 and 500 mg/m2 and even more preferred between 50 and 250 mg/nr.
-8The mixing ratio of the active compounds of deltamcthrin (compound of group A) with clothianidin (compound of group B) is advantageously and preferably for the use of mosquitos from 1:1 to 1: 200, preferably from, 1:1 to 1:40, more preferably from 1:2 to 1:20, even more preferably from 1:4 to 1:10, most preferably 1:8.
As a further unexpected resuit it has been found that the combination of deltamethrin and clothianidin is efficient against the herein discussed pests (and in particular mosquitoes, preferabyl mctabolic-resistant mosquitos, preferably Anopheles funestus, more preferably the strain FUMOZ-R) on surfaces such as concrète, tile and wood.
The active compound combination according to the invention may comprise further components, for example additional active compounds of a different type (e.g. other insecticides, antibacterial compounds, fungicides, herbicides etc.) and/or additives customary in crop protection and/or formulation auxiliaries, or may be used together with these compounds. However, the active compound combination according to the invention does not comprise piperonyl butoxid (PBO).
The active compound combinations of the invention can be converted to customary formulations, such as solutions, émulsions, wettable powders, suspensions, powders, dusts, pastes, soluble powders, granules (such as water dispersible granules), suspension-emulsion concentrâtes, tablets, bait formulations, smokc producing formulations, gels, foams, aérosols, natural materials imprcgnatcd with the active compound combinations of the invention, synthetic materials impregnated with the active compound combinations of the invention and microencapsulations of the active compound combinations of the invention in polymeric substances. These formulations can be used directly, as ready to use, or after dilution in the application medium.
These formulations are produced in a known manner, for example by mixing the active compounds/active compound combination with extenders, that is liquid solvents and/or solid carriers, optionally with the use of surfactants, that is emulsifiers and/or dispersants, adjuvants, that is substances which improve the biological performance without having an own biological activity, antifoam, preservatives, antioxidants, colourants, anti-freeze, pH stabilizers, thickencrs, and/or foam-formers.
Suitable for use as auxiliaries are substances which are suitable for imparting to the active compounds/active compound combination itself and/or to préparations derived therefrom (for example spray liquors, seed dressings) particular properties such as certain technical properties and/or also particular biological properties. Typical suitable auxiliaries are: extenders, solvents and carriers.
Suitable extenders are, for example, water, polar and nonpolar organic chemical liquide, for example from the classes of the aromatic and non-aromatic hydrocarbons (such as paraffine, alkylbenzenes, alkylnaphthalcncs, chlorobcnzcncs), the alcohols and polyols (which, if appropriate, may also be
-9substituted, etherified and/or esterifïed), the ketones (such as acetone, cyclohexanone), esters (including fats and oils) and (poly)ethcrs, the unsubstituted and substituted amines, amides, lactams (such as Nalkylpyrrolidones) and lactones, the sulphones and sulphoxides (such as dimethyl sulphoxide).
If the extender used is water, it is also possible to cmploy, for cxamplc, organic solvents as auxiliary solvents. Essentially, suitable liquid solvents are: aromatics such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons such as cyclohexane or paraffins, for example petroleum fractions, minerai and vegetable oils, alcohols such as butanol or glycol and also their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethylformamide and dimethyl sulphoxide, and also water.
Suitable solid carriers are: for example, ammonium salts and ground natural minerais such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerais, such as finely divided silica, alumina and silicates; suitable solid carriers for granules are: for example, crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite and dolomite, and also synthetic granules of inorganic and organic meals, and granules of organic material such as paper, sawdust, coconut shells, maize cobs and tobacco stalks; suitable emulsifiers and/or foam-formers are: for example, nonionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, for example alkylaryl polyglycol ethers, alkylsulphonates, alkyl sulphates, arylsulphonates and also protein hydrolyzates; suitable dispersants are nonionic and/or ionic substances, for example from the classes of the alcohol-POE- and/or -POP-ethers, acid and/or POP-POE esters, alkyl aryl and/or POP- POE ethers, fat- and/or POP-POE adducts, POE- and/or POP-polyol dérivatives, POE- and/or POP-sorbitan- or -sugar adducts, alkyl or aryl sulphates, alkyl- or arylsulphonates and alkyl or aryl phosphates or the corresponding PO-ether adducts. Furthermore, suitable oligo- or polymers, foi’ example those derived from vinylic monomers, from acrylic acid, from EO and/or PO alone or ni combination with, for example, (poly)alcohols or (poly)amines. It is also possible to employ lignin and its sulphonic acid dérivatives, unmodified and modified celluloses, aromatic and/or aliphatic sulphonic acids and their adducts with formaldéhyde.
Thickeners such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules or laticcs, such as gum arabic, polyvinyl alcohol and polyvinyl acetate, as well as natural phospholipids such as cephalins and lecithins, and synthetic phospholipids, can be used in the formulations. Further additives may be minerai and vegetable oils.
It is possible to use colorants such as inorganic pigments, for example iron oxide, titanium oxide and Prussian Blue, and organic dyestuffs, such as alizarin dyestuffs, azo dyestuffs and métal phthalocyanine
-10dyestuffs, and trace nutrients such as salts of iron, manganèse, boron, copper, cobalt, molybdenum and zinc.
In a particularly preferred embodiment the active compound combinations of the invention arc convcrtcd to suspensions concentrâtes (SC), water dispcrsablc granules (WG) or wcttablc powders (WP). Suspension concentrâtes (SCs) are usually made by premixing the active ingrédient powder in an aqueous solution of a liquid extender and a dispersant, followed by a wet grinding process in a bead mill to give a particle size in the range of 1 - 10 microns. Water dispersable granules (WGs) can be formulated using various processing techniques, resulting in products which redispersc or dissolve in water e.g. in the spray tank. The main processes for granulation to achieve WGs for the active compound combinations of the invention are: a) pan granulation, b) high speed mixing agglomération, c) extrusion granulation, d) fluid bed granulation, e) fluid bed spray granulation, f) spray drying, possibly with in-built agglomération process. Wcttablc powders (WPs) arc usually made from solid active ingrédients which are fine grinded through a hammer or pin type mill or a fluid energy micronizer. The powders contain dry surfactants as powder wetting and dispersing agents and inert carriers or fillers. WPs are preferably used in water-soluble bags. Water-soluble bags are known to a skilled person in the art and may e.g. consist of polyvinyl alcohol (PVA) or other water-soluble material.
The active compound composition of the invention can be used for liquid applications such as e.g. a spray solution to control animal pests on a variety of surfaces. The treatment of surfaces for example within or outside from buildings is necessary to control spreading of diseases that are transmitted by vectors (such as mosquitos) that transmit diseases or that annoy animais and humans. There is a great need for protecting the inhabitants effectively and with a long-lasting residuality. Moreover, reasons of hygiene and structural engineering require that animal pests be prevented from entering into buildings, spreading and dwelling in buildings and infesting wood or other materials.
Other uses include the intégration or coating of the active compound composition according to the invention into/of materials such as pcllcts, granules, dusts, yarns, foils, slccping mats, mosquito nets, textiles, wovens, braids, knits, felts, nonwovens, curtains, draperies, tarpaulins, fabrics, wood, papers, furnitures, fences in particular animal fences, paints etc. (intégration of active ingrédients into foils and mosquito nets is e.g. described in WO-A-2009/121580; PCT/EP2011/0055822, WO2011/128380).
The présent invention also relates to a material which comprises the active compound composition of the invention. The material is preferably selected from the group of foil, sleeping net, sleeping mat, mosquito net, textile, woven, braid, knit, felt, nonwoven, curtain, drapery, tarpaulin, fabric, wood, paper, furniture, fence preferably animal fence, paint.
Another preferred embodiment of the invention relates to a bed bug bait which comprises the active compound composition of the invention and means to attract bed bugs. Means to attract bed bugs are
- 11 known to a skilled person in the art (see e.g. WO 2011/149899).
Alternatively, in another embodiment of the invention, the active compound combination is used to control bed bugs via an ovicidial activity. For this purpose, the active compound combination of the invention is applied to (e.g. sprayed on) bed bugs and cggs directly (such as e.g. on bedsprings, box springs, and the interior of bed trames or headboards, including ail cracks and joints).
A further embodiment of this invention relates to the use of the above described material to control animal pests, preferably arthropode, preferably insccts and more preferably mosquitos and/or bed bugs in particular insecticide-resistant mosquitos and/or insecticide-resistant bed bugs and more preferably mosquitos and/or bed bugs that are target-site- and/or metabolic-resistant. Another preferred embodiment relates to the use of such a material to control insecticide-resistant mosquitos wherein the insecticide-resistant mosquitos are selected from the group of Anopheles gambiae, preferably the strain RSPH and Anopheles funestus, preferably the strain FUMOZ-R. In another preferred embodiment the current invention relates to the use of such a material to control pyrethroid and/or carbamate-resistant mosquitos, preferably pyrethroid and/or carbamate-resistant Anopheles gambiae and/or Anopheles funestus mosquitos. More preferably, the material of the présent invention is used to control pyrcthroidresistant mosquitos, preferably pyrethroid-resistant Anopheles gambiae and/or Anopheles funestus mosquitos. Another preferred embodiment of the invention relates to the use of such a material to control multi-resistant mosquitos.
The invention also relates to the use of the above described material to control pyrethroid-resistant bed bugs. In a preferred embodiment, the material is used to control pyrethroid-resistant bed bugs, wherein the bed bugs hâve a Valine to Leucine mutation (V419L) and/or a Leucine to Isoleucine mutation (L925I) in the voltage-gated sodium channel alpha-subunit gene.
The good insecticidal activity of the active compound combinations is illustrated by the examples below. Whereas the individual active compounds show weaknesses in their activity, the combinations show an activity which exceeds a simple addition of activities.
A synergistic effect of the active compound combination is always présent when the activity of the active compound combination exceeds the total of the activities of the active compounds when applied individually.
The expected activity for a given combination of two active compounds can be calculated according to S.R. Colby, Weeds 15 (1967), 20-22 as follows:
If
- 12X is the kill rate, expressed in % of the untreated control, when active compound A is applied at an application rate of m g/ha or at a concentration of m ppm,
Y is the kill rate, expressed in % of the untreated control, when active compound B is applied at an application rate of n g/ha or at a concentration of n ppm and
E is the kill rate, expressed in % of the untreated control, when active compounds A and B are applied at application rates of m and n g/ha or at a concentration of m and n ppm, then
ΧΎ e=x + yIf the actual insecticidal kill rate is greater than calculated, the kill of the combination is superadditive,
i.e. there is a synergistic effect. In this case, the actual observed kill rate has to be greater than the value for the expected kill rate (E or hereinafter in the tables also Colby exp. %) calculated from the formula given above.
If, in the context of this description, the short form of the “common name” of an active compound is used, this comprises in each case ail customary dérivatives, such as the esters and salts, and isomers, in particular optical isomers, especially the commercially available form or forms. If the “common name” refers to an ester or a sait, this in each case also comprises ail other customary dérivatives, such as other esters and salts, the free acids and neutral compounds, and isomers, in particular optical isomers, especially the commercially available form or forms. The terms “combination” and “composition” are used as synonyms throughout this application.
- 13 Examples
1. Metabolic-resistant Anopheles test
Solvent: Acetone
To produce a suitable préparation of active compound combination the active compounds deltamethrin and clothanidin were dissolved in acetone (for the control group only one active compound was dissolved in acetone). The active compound combination préparation (and the active compound preperations) were pipetted onto a glazed tile, wood and concrète and, after drying, adult mosquitoes of the species Anopheles funestus metabolic-resistant strain FUMOZ-R (Hunt et al., Med Vet Entomol. 2005 Sep; 19(3):271-5) are placed onto the treated tile, wood and concrète. The exposition time is 10 30 minutes.
hour, 2 hour, 4 hour, 24 hours after contact to the treated surface, the mortality proportion of the test animais in % is determined. Here, 100% means that ail mosquitoes hâve been killed; 0% means that none of the mosquitoes has been killed. The treated tile, wood and concrète was stored under stress conditions (30 °C/ 80% rh). Measurement with the treated tile, wood and concrète was repeated 5 weeks 15 (Table 1), 11 weeks (Table 2) and 60 weeks (Table 3) after the treatment with the active compound combination.
Table. 1: Deltamethrin and Clothianidin / Anopheles funestus / Mortality 5 weeks after treatment
| Concentration/ mg/m2 | Concentration / mg/m2 | Hours after contract to the treated surface | lh | 2h | 4h | 24h | lh | 2 h | 4h | 24h | lh | 2h | 4h | 24h | |
| Deltamet brin | CJothiani din | Surface | Tile | Wood | Concrète | ||||||||||
| Deltamethrin alone | 12.5 | 0 | Eflect% | 17 | 77 | 97 | 100 | 10 | 77 | 80 | 77 | 70 | 87 | 100 | 30 |
| 25 | 0 | Effect% | 7 | 83 | 100 | 93 | 30 | 90 | 93 | 83 | 90 | 100 | 100 | 73 | |
| Clothianidin alone | 0 | 100 | Effect% | 0 | 7 | 7 | 80 | 7 | 20 | 27 | 93 | 15 | 10 | 30 | 93 |
| 0 | 200 | Effect% | 0 | 0 | 10 | 90 | 7 | 10 | 20 | 93 | 3 | 17 | 30 | 83 | |
| Deltamethrin and Clothianidin | 12.5 | 100 | Effect% | 20 | 60 | 97 | 80 | 50 | 77 | 93 | 83 | 67 | 100 | 100 | 93 |
| 12.5 | 100 | Colby exp. | 17 | 78,61 | 97,2 | 100 | 16,3 | 81,6 | 85,4 | 98,39 | 74,5 | 88,3 | 100 | 95,1 | |
| 25 | 100 | Effect% | 43 | 80 | 83 | 80 | 30 | 83 | 93 | 87 | 80 | 95 | 100 | 97 | |
| 25 | 100 | Colby exp. | 7 | 84,19 | 100 | 98,6 | 34,9 | 92 | 94,9 | 98,81 | 91,5 | 100 | 100 | 98,1 | |
| 12.5 | 200 | Effect% | 17 | 90 | 100 | 77 | 3 | 60 | 87 | 97 | 70 | 90 | 100 | 97 | |
| 12.5 | 200 | Colby exp. | 17 | 77 | 97,3 | 100 | 16,3 | 79,3 | 84 | 98,39 | 70,9 | 89,2 | 100 | 88,1 | |
| 25 | 200 | Effect% | 60 | 97 | 100 | 97 | 73 | 100 | 100 | 100 | 75 | 95 | 100 | 93 | |
| 25 | 200 | Colby exp. | 7 | 81 | 100 | 99,3 | 34,9 | 91 | 94,4 | 98,81 | 90,3 | 100 | 100 | 95,4 |
-14Table. 2: Deltamethrin and Clothianidin / Anopheles funestus / Mortality 11 weeks after treatment
| Concentration / mg/m2 | Concentration / mg/m2 | Hours after contract to the treated surface | lh | 2h | 4h | 24h | lh | 2h | 4h | 24h | lh | 2h | 4h | 24h | |
| Délia met brin | Cblliiani din | Surface | Tile | Wood | Concrète | ||||||||||
| Deltamethrin alone | 12.5 | 0 | Effect0/» | 0 | 0 | 0 | 3 | 0 | 0 | 20 | 13 | 3 | 0 | 17 | 30 |
| 25 | 0 | Effect% | 10 | 33 | 43 | 63 | 0 | 27 | 80 | 70 | 13 | 43 | 63 | 73 | |
| Clothianidin alone | 0 | 100 | Effect0/» | 7 | 10 | 13 | 37 | 0 | 3 | 33 | 27 | 23 | 67 | 73 | 93 |
| 0 | 200 | Effect0/» | 7 | 20 | 43 | 73 | 13 | 17 | 17 | 40 | 3 | 17 | 47 | 83 | |
| Deltamethrin and Clothianidin | 12.5 | 100 | Effect/» | 13 | 37 | 40 | 30 | 10 | 43 | 50 | 50 | 67 | 83 | 93 | 93 |
| 12.5 | 100 | Colby exp. | 7 | 10 | 13 | 38,9 | 0 | 3 | 46,4 | 36,49 | 25,3 | 67 | 77,6 | 95,1 | |
| 25 | 100 | Effcct% | 13 | 47 | 80 | 87 | 30 | 57 | 97 | 87 | 33 | 77 | 90 | 97 | |
| 25 | 100 | Colby exp. | 16,3 | 39,7 | 50,4 | 76,7 | 0 | 29,2 | 86,6 | 78,1 | 33 | 81,2 | 90 | 98,1 | |
| 12.5 | 200 | Effect/» | 7 | 50 | 80 | 83 | 0 | 30 | 70 | 53 | 37 | 70 | 90 | 97 | |
| 12.5 | 200 | Colby exp. | 7 | 20 | 43 | 73,8 | 13 | 17 | 33,6 | 47,8 | 5,91 | 17 | 56 | 88,1 | |
| 25 | 200 | Effect% | 13 | 67 | 93 | 100 | 33 | 73 | 90 | 90 | 37 | 93 | 93 | 93 | |
| 25 | 200 | Colby exp. | 16.3 | 46,4 | 67,5 | 90 | 13 | 39,4 | 83.4 | 82 | 15,6 | 52,7 | 80,4 | 95,4 |
Table. 3: Deltamethrin and Clothianidin / Anopheles funestus / Mortality 60 weeks after treatment
| Concentration / mg/m2 | Concentration / mg/m2 | Hours after contract to the treated surface | lh | 211 | 4h | 24h | lh | 2 h | 4h | 24h | lh | 2h | 4h | 24 h | |
| Dellaniet brin | Clotliiaiii din | Surface | Tile | Wood | Concrète | ||||||||||
| Deltamethrin alone | 12.5 | 0 | Effect0/» | 0 | 0 | 17 | 30 | 0 | 0 | 17 | 43 | 0 | 0 | 0 | 13 |
| 25 | 0 | Effect0/» | 0 | 7 | 23 | 53 | 0 | 10 | 37 | 43 | 0 | 0 | 0 | 23 | |
| Clothianidin alone | 0 | 100 | Effect0/» | 0 | 0 | 0 | 17 | 0 | 0 | 0 | 10 | 0 | 3 | 20 | 37 |
| 0 | 200 | Effect/» | 0 | 3 | 7 | 43 | 0 | 3 | 3 | 17 | 0 | 7 | 17 | 63 | |
| Deltamethrin and Clothianidin | 12.5 | 100 | Effect0/» | 0 | 7 | 17 | 40 | 0 | 23 | 53 | 60 | 0 | 13 | 23 | 77 |
| 12.5 | 100 | Colby exp. | 0 | 0 | 17 | 41,9 | 0 | 0 | 17 | 48,7 | 0 | 3 | 20 | 45,2 | |
| 25 | 100 | Effect% | 0 | 23 | 67 | 87 | 0 | 67 | 87 | 93 | 0 | 7 | 33 | 70 | |
| 25 | 100 | Colby exp. | 0 | 7 | 23 | 61 | 0 | 10 | 37 | 48,7 | 0 | 3 | 20 | 51,5 | |
| 12.5 | 200 | Effect0/» | 0 | 10 | 30 | 53 | 0 | 27 | 63 | 73 | 0 | 7 | 20 | 80 | |
| 12.5 | 200 | Colby exp. | 0 | 3 | 22,8 | 60,1 | 0 | 3 | 19,5 | 52,69 | 0 | 7 | 17 | 67,8 | |
| 25 | 200 | Effect/» | 0 | 0 | 67 | 73 | 0 | 13 | 43 | 63 | 0 | 13 | 60 | 83 | |
| 25 | 200 | Colby exp. | 0 | 9,79 | 28,4 | 73,2 | 0 | 12,7 | 38,9 | 52,69 | 0 | 7 | 17 | 71,5 |
2. Efficiency of Deltamethrin and Clothianidin against bed bugs (Cimex Lectularius, strain Cincinnati (CIN-1)
To produce a suitable préparation Deltamethrin and Clothianidin was dissolved in acetone in various concentrations. Efficacy tests were done by placing 10 bed bug test animais (Cimex Lectularius, strain 10 Cincinnati (CIN-1)) onto a glazed tile and plywood. The prepared solutions in concentration of 6.25 mg/m2 Deltamethrin and 50 mg/nr Clothianidin were sprayed with a glass nozzle on glazed tile and plywood. The bed bugs were added to the sprayed glazed tile and plywood 1 and 3 weeks after spraying.
After 30 min. exposure time the bedbugs were transferred from the treated surface to plastic cups and
- 15the knock-down proportion of the test animais was determined 1 hour and 24 hours after the contact.
Knock-down values of between 93 to 100% were measured.
Claims (15)
- Patent claims1. Use of an active compound composition for vector control comprising deltamethrin and sccondly at least one further active compound selected from the group of neonicotinoids with the proviso that the active compound composition does not comprise pipcronyl butoxid.
- 2. Use of an active compound composition according to claim 1 for Malaria and Dengue vector control.
- 3. Use of an active compound composition according to one of the previous claims wherein the vectors are mosquitos.
- 4. Use of an active compound composition according to one of the previous claims wherein the vectors are insecticide-resistance mosquitos.
- 5. Use of an active compound composition for insecticide-resistant mosquito and/or insecticide résistant bed bug control comprising deltamethrin and secondly at least one further active compound selected from the group of neonicotinoids with the proviso that the active compound composition does not comprise piperonyl butoxid.
- 6. Use of an active compound composition according to one of the claims 4 and 5 wherein the insecticide-resistant mosquitos are target-site- and/or metabolic-resistant mosquitos.
- 7. Use of an active compound composition according to claim 6 wherein the target-site- and/or metabolic-resistant mosquitos are pyrethroid and/or carbamate-resistant mosquitos.
- 8. Use of an active compound composition according to one of the claims 6 and 7 wherein the vectors are multi-resistant mosquitos.
- 9. Use of an active compound composition according to one of the claims 6 to 7 wherein the insecticide-resistant mosquitos are metabolic-resistant mosquitos selected from the group of Anopheles fîmes tus, preferably the strain FUMOZ-R.
- 10. Use of an active compound composition according to claim 5 for target-site- and/or metabolicresistant bed bug control.
- 11. Use of an active compound composition according to claim 10 wherein the bed bugs are pyrethroid-resistant bed bugs.
- 12. Use of an active compound composition according to one of the previous claims wherein the active compound combination is applied only once to a surface for a time period of at least 11 weeks.
- 13. Use of an active compound composition according to claim 12 wherein the applied active5 compound combination on the surface acts synergistically after a period of at least 11 weeks without additional active compound composition application on the same surface.
- 14. Use of an active compound composition according to claim 13 wherein the surface is porous and/or alkaline.
- 15. Use of an active compound composition according to one of the preccding claims comprising10 deltamethrin and clothianidin.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14173656.1 | 2014-06-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA18212A true OA18212A (en) | 2018-09-04 |
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