NZ794880A - A stable, self-dispersible, low foaming solid pesticide formulation - Google Patents
A stable, self-dispersible, low foaming solid pesticide formulationInfo
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- NZ794880A NZ794880A NZ794880A NZ79488017A NZ794880A NZ 794880 A NZ794880 A NZ 794880A NZ 794880 A NZ794880 A NZ 794880A NZ 79488017 A NZ79488017 A NZ 79488017A NZ 794880 A NZ794880 A NZ 794880A
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Abstract
The present subject matter relates to a stable pesticidal formulation which exhibits improved dispersibility in cold water and full compatibility with fertilizers.
Description
The present subject matter s to a stable pesticidal formulation which exhibits improved
dispersibility in cold water and full compatibility with fertilizers.
NZ 794880
A , SELF- DISPERSIBLE, LOW G SOLID PESTICIDE
FORMULATION
This application is a divisional of New Zealand al Phase Application No.
754449, the New Zealand National Phase application of filed on
7 December 2017, and claims priority from U.S. ional Application No.
62/431,342 filed on 7 December 2016, the entire content of each is hereby incorporated
by reference herein in their entirety.
Throughout this application, various publications are cited. Disclosures of the
documents and publications referred to herein are hereby incorporated in their entireties
by reference into this application.
TECHNICAL FIELD
The present subject matter relates to pesticidal ations for use in agricultural pest
control applications. In particular, this subject matter provides a stable pesticidal
formulation which exhibits improved dispersibility in cold and hard water and
compatibility with fertilizers.
BACKGROUND
Many pesticidal formulations are in the form of solid formulations which are applied
under various conditions and /or with other additives such as adjuvant and izer.
These agricultural formulations must t excellent chemical stability and a high
level of physical stability during the preparation, storage and application process.
r, many solid formulations are unpredictable and complex in nature due to the
physical incompatibility of many pesticides and izers especially under severe
conditions such as hard and/or cold water. This incompatibility can result in the
formation of agglomerates due to ation, flocculation, gelling, or precipitation of
solid particles of the pesticide in the spray tank. These formulations have generally poor
dispersion in water resulting in clogging of the nozzles and filters of spraying
equipment.
ations in powder form or in granular form are often introduced to the spray tank
through a mesh by adding water to the tank. The water available to the farmer may be
cold hard water. The hardness of the water may be from 350 ppm to 1000 ppm of
calcium carbonate. The temperature of the hard water can be as cold as 4—6°C. Such
cold water poorly disperses the active components, thereby leading to clogging the
mesh of the spray tank and causing a loss of pesticide. Sometimes it is quite impossible
to load the spray tank with all required pesticide portion due to the clogging.
Some granular ations, comprising for example Captan and , produce a
large amount of foam when added to the spray tank anti ively stirred. High
foaming leads to losses of the spraying solution and limits efficiency of the spraying
process.
These formulations may thereby produce poor spraying performance with resultant
damage to crops and/or ineffectiveness of treatment. it has been ized that this
physical incompatibility could be overcome to some limited extent by the use of
combinations ning sw‘factants, wetting agents and dispersants or by the addition
of various compatibility agents.
Based on the fact that no l solution of the incompatibility problem of pesticides
and fertilizers , there is a need in the art for new pesticidal formulations with
improved dispersibility. physical stability, and which are also compatible with
ferti lizers.
Applying pesticides in a high electrolyte environment results in enormous amounts of
foam which makes it difficult to dilute and apply the composition Based on the aspects
discussed above, there is a need in the art for a new pesticidal formulation comprising
combinations and applications of ary chemicals which have both high
compatibility characteristics and a good environmental safety profile.
When mixing a formulation with cold and/or hard water, there is a need to disintegrate
and disperse the resulting particles in order to e the dispersibility of the particles.
increasing disintegration and dispersion of granules in cold water is knosm in the art
using an effervescent agent and increasing the amount oi‘dispersing and wetting agents.
US 6,2 74, l 56 discloses effervescent granules which are mixed with pesticidal granules.
US 5,516,529 discloses effervescent granules which comprise water insoluble
substances that are capable of absorbing the water.
However. higher amounts of dispersing agent and effervescent agent in a formulation
te increased foam in the presence of water and may lead to increased use of
antifoaming agent. Antifoaming agents are sensitive to environment conditions such as
temperature and electrolyte.
During the last decade, the need for new agrochemical formulations with high
performance has been increasing.
There is a need to p a highly physically stable formulation. which has high
stability during the preparation, e and application process of the formulation.
SUMMARY
The present invention further provides a stable, self-dispersible, low foaming solid
formulation comprising:
a) at least one pesticide;
b) an effective amount ofan oaming agent; and
c) an effective amount of escent system.
The present invention further provides a stable, self-dispersible, low foaming solid
formulation comprising:
a) at least one pesticide;
b) an effective amount of a solid or a liquid oil-based anti-foaming agent; and
c) an effective amount of effervescent system.
The present invention es a stable, self—dispersible, low foaming solid formulation
comprising:
a) an effective amount of pesticide;
b) an effective amount of a solid or liquid oil-based anti-foaming agent: and
c) an effective amount of effervescent ,
wherein the formulation is compatible with cold and/or hard water.
The present invention provides a stable. self-dispersible, low foaming solid formulation
comprising:
a) an ive amount of ide;
b) an effective amount of a solid or a liquid oil-based anti-foaming agent; and
c) an effective amount of effervescent system,
wherein the formulation is formulated for application in the presence of cold and/or
hard water.
The present invention provides a stable, self-dispersible, low foaming solid
formulation comprising:
a) at least one pesticide in an amount of 25-85% by weight based on the total
weight of the formulation;
b) a solid or a liquid oil-based anti~foaming agent in an amount of up to 10%
by weight based on the total weight of the formulation; and
c) an effervescent system in an amount of at least 3-25% by weight based on
the total weight of the formulation,
wherein the formulation is compatible with cold and/or hard water.
The present invention further provides a stable, self-dispersible. low foaming solid
formulation comprising:
a) at least one phthalimide fungicide;
b) an effective amount ofa solid or a liquid oil—based oaming agent; and
c) an effective amount of effervescent system.
The present invention yet r provides a method of preparing a stable, self—
sibie. low foaming solid formulation comprising a solid antifoaming agent,
wherein the method comprises:
(i) mixing an effective amount of pesticide, an effective amount of the solid
anti~foaming agent and an effervescent ; and
(ii) granulating the mixture to obtain granules.
The present invention yet further provides a manufacturing process of a stable, self-
sible, low g solid formulation comprising a solid antifoaming agent.
wherein the cturing process comprises:
(i) mixing an effective amount of a pesticide, an effective amount of the solid
anti-foaming agent and an effective amount of escent system; and
(ii) granulating the mixture to obtain granules.
The present ion also provides a method of preparing a stable. self-dispersible,
low g solid formulation formulations comprising a liquid anti-foaming agent,
wherein the method comprises:
(i) mixing an effective amount of a ide and an effective amount of an
effervescent system;
(ii) granulating the mixture to obtain es; and
(iii) applying an effective amount of the liquid oil-based anti-foaming agent to
the obtained granules.
The present ion also provides a manufacturing process of a stable, self—
dispersible, low foaming solid formulation formulations comprising a liquid anti-
foaming agent, wherein the manufacturing process comprises:
(i) mixing an effective amount of a pesticide and an effective amount of an
effervescent system;
(ii) granulating the mixture to obtain granules; and
(iii) applying an effective amount of the liquid oil-based anti—foaming agent to
the obtained granules.
The present invention provides a stable, self—dispersible, low foaming solid formulation
comprising;
a) an effective amount of ide;
b) an effective amount of a solid or a liquid oil-based anti-foaming agent;
c) an effective amount of ling system: and
d) an effective amount of effervescent system,
wherein the formulation is compatible with cold and/or hard water or is formulated for
application in the ce of cold and’or hard water. and wherein the ratio of the
effervescent system to the dispelling system is 20:1 to 1:10.
The present invention es a stable, self-dispersible, low foaming solid
formulation comprising:
a) at least one pesticide in an amount of 25-85% by weight based on the total
weight of the formulation;
b) a solid or a liquid oil-based anti-foaming agent in an amount of up to 10%
by weight based on the total weight of the formulation;
c) a dispelling system in amount of up to 45% by weight based on the total
weight ofthe formulation; and
d) an effervescent system in an amount of at least 3-2596 by weight based on
the total weight of the formulation,
wherein the formulation is ible with cold and/or hard water.
The present invention further provides a stable, self—dispersible, low foaming solid
formulation comprising:
a) at least one pesticide;
b) an effective amount of a solid or a liquid sed anti-foaming agent;
0) a dispelling system in amormt of up to 45% by weight based on the total
weight of the formulation; and
d) an effective amount of effervescent .
The t invention further provides a stable. self-dispersible, low foaming solid
formulation comprising:
a) at least one phthalimide fungicide:
b) an effective amount of a solid or a liquid oil-based anti-foaming agent;
c) a dispelling system in amount of up to 45% by weight based on the total
weight of the ation; and
d) an effective amount of an effervescent system.
The present invention yet further provides a method of preparing a . self-
dispersible. low foaming solid ation comprising a solid anti-foaming agent,
wherein the method comprises:
(i) mixing an effective amount of pesticide, an effective amount of the solid
anti-foaming agent, and an effervescent system; and
(ii) granulating the e to obtain granules.
'llie present invention yet further provides a manufacturing process of a stable, self—
dispersible, low foaming solid formulation comprising a solid anti-foaming agent.
wherein the manufacturing process comprises:
(i) mixing an effective amount of a pesticide, an effective amorutt of the solid
anti-foaming agent, and an effective amount of effervescent system; and
(ii) granulating the mixture to obtain granules.
The present ion yet r provides a method of preparing a stable. self-
dispersible. low foaming solid formulation comprising a liquid oil-based anti-foaming
agent, n the method comprises:
(i) mixing an effective amount of pesticide and an effervescent system;
(ii) granulating the mixture to obtain granules; and
(iii) applying an effective amount of the liquid oil~based anti~foaming agent to
the obtained granules.
The t invention yet further provides a cturing process of a stable, self-
dispersible, low foaming solid formulation comprising a liquid oil—based anti-foaming
agent, wherein the manufacturing process comprises:
(i) mixing an effective amount of a pesticide and an effective amount of
escent ;
('ii) granulating the mixture to obtain granules; and
(iii) applying an effective amount of the liquid oil—based anti-foaming agent to
the obtained granules.
The present invention yet further es a method of preparing a stable. self-
dispersible, low foaming solid formulation comprising a solid oaming agent,
wherein the method comprises:
(i) mixing an effective amount of pesticide, an effective amount of the solid
anti-foaming agent. and an effervescent system; and
(ii) milling the mixture to obtain powder.
The present invention further es a method of controlling or preventing a disease
caused by phytopathogenic fungi on plants or propagation material thereof, comprising
ting the plants, the locus thereofor propagation material thereof with an effective
amount of at least one of the herein defined formulations.
According to another aspect, the present invention provides a method of controlling
undesired vegetation comprising applying to a locus of the undesired vegetation an
effective amount of at least one of the herein defined formulations.
According to another aspect, the present ion provides a method for controlling
unwanted insects comprising applying to an area infested with said insects an effective
amount of at least one of the herein defined formulations.
DETAILED DESCRIPTION
Definitions
All technical and scientific terms used herein have the same meanings as commonly
understood by someone ordinarily skilled in the art to which the present subject matter
s. The following definitions are provided for clarity.
As used herein. the term "pesticide" broadly refers to an agent that can be used to
control and/or kill a pest. The term is understood to include but is not limited to
fungicides, insecticides, nematicides, ides, acaricides, parasiticides or other
control agents. For chemical classes and applications. as well as specific compounds of
each class, see "The Pesticide Manual Thirteenth Edition" (British Crop tion
Council. Hampshire. UK, 2003), as well as "The e-Pesticide Manual. Version 3"
(British Crop Protection Council. ire. UK. 2003-04), the contents of each of
which are incorporated herein by reference in their entirety.
As used herein the term ”plant“ or "crop" includes reference to whole plants, plant
organs (eg. leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc), plant cells, or
plant seeds. This term also asses plant crops such as fruits and vegetables. in
some embodiments, the term "plant" may include the propagation material thereof.
which may include all the tive parts of the plant such as seeds and vegetative
plant material such as cuttings and , which can be used for the multiplication of
the plant. This includes seeds, tubers, spores, corms, bulbs. rhizomes. sprouts basal
shoots, stolons. and buds and other parts of plants, including seedlings and young
plants, which are to be transplanted after ation or after emergence from soil.
As used , the term "locus" includes not only areas where ests mar already exist,
. 5 .
but also areas where pests have yet to emerge, and also to areas under cultivation.
As used herein. the term “mixture” or "combination" refers. but is not limited to. a
combination in any physical form, eg. blend. on, or the like.
As used herein, the term "stable“ when used to characterize a solid formulation
comprising an effervescent system means that the effervescent system does not
substantially react before wetting. For example, the effervescent system does not
substantially react when exposed to the moisture present in the air at less than 40% RH
or to the moisture in the formulation prior to wetting.
As used herein, the term "low foaming" when used to characterire a solid formulation
means that the level of persistent foam is within limits of standard test of SANCO.
As used herein, the term "self-dispersible" refers to the sion of micro-particles in
the liquid phase without the need for ng.
The formulations of the subject invention are advantageous because these formulations
are self-dispersible and low foaming in the presence of cold and"or hard water.
As used herein. the term "effervescent" refers to the escape of gas from an aqueous
solution.
As used herein, the term “dispelling" refers to the dissipation of granules in water to
the primary ized solid particles of active ient from which the granules are
built.
As used herein, the term “liquid granulation aid" refers to an ve that reduces the
friction between particles es the granulation process by reducing the temperature
during the granules production and increases the stability of the formulation
components.
As used . the term “composition” refers to art undiluted formulation disclosed
herein before application.
As used herein, the term “end use composition" refers to a diluted formulation disclosed
herein before application.
As used . the phrase "agriculturally acceptable carrier" means rs which are
known and accepted in the art for the formation of formulations for agricultural or
horticultural use.
As used herein. the term “”a or ”an as used herein includes the singular and the plural,
unless specifically stated otherwise. Therefore, the terms "a," "an" or "at least one" can
be used interchangeably in this application.
Throughout the application, descriptions of various embodiments use the term
ising": r. it will be understood by one of skill in the art, that in some
specific instances, an embodiment can tively be described using the language
“consisting essentially of’ or "consisting of."
For purposes of better understanding the present teachings and in no way limiting the
scope of the teachings, each numerical parameter should be construed in light of the
number of ed icant digits and by applying ordinary rounding techniques. In
this regard, used of the term "about” herein specifically includes i109?) from the
indicated values in the range. In addition, the endpoints of all ranges directed to the
same component or property herein are inclusive of the endpoints, are ndently
combinable. and include all intermediate points and ranges.
i’esticidal Formulations
Formulation for use in cold water and high electrolyte environment are very ive
to foam formation and controlling foam formation is difficult due to the dispersing
agent, the temperature of the water and the concentration of electrolyte. All these
dramatically influence the effectiveness of the antifoaming agent and the concentration.
in addition. formulations comprising an effervescent system are very ive to
moisture and such solid formulations should contain a very limited amount of water to
ensure stability.
The t invention provides a pesticidal formulation which comprises an
effervescent system. a dispelling system and an antifoaming agent. wherein the amount
of moisture in the formulation is limited and the formulation is stable. In some
embodiments, the moisture in the formulation is less than 3%. Preferably. the moisture
in the formulation is less than 1%.
The present invention relates to a pesticidal formulation that ts good chemical
and physical stability under normal storage conditions and also shows improved
dispersibility in water and is compatible when mixed with fertilizers.
Chemical and physical stability is commonly considered to be "good” if the formulation
passes the following Cll’AC test that is standard in the relevant industry before and
after storage stability test (2 week at 54°C or equivalent - after 8 week at 40°C):
1. Active ingredient (Al) concentration is stable according to the acceptable
values in the ry (for example above concentration of50% Al -.+. 25 gr/kg
of the ed content);
to pH (in 1% solution) stable 2': 2;
3. Persistent foam (0.5%) (Temp=5¢C) < 60 ml after 1 minute;
41 MT 185 — Wet sieve test < l 0/6 (10%, 75pm);
'J‘ Suspensibility (0.5%) > 60%;
6. Wettability (10%) (Temp==:5°C) Less than 5 seconds; and
7. PSD, D90 <21 t1.
Normal storage condition is two years storage at room ature or under accelerated
storage ity test: after 2 weeks at 54°C or equivalent - after 8 weeks at 40°C or
after 12 weeks at 35°C.
The invention es a pesticidal formulation that produces a limited and reduced
amount of foam.
in some embodiments, the amount of foam is tested by standard ClPAC test. 1n some
embodiments, the anti-foaming agent is ive to reduce persistent foam of 0.5%
formulation in cold and/or hard water under rd CIPAC test. Persistent foam may
be measured by diluting a formulation in a measuring cylinder of standard dimensions
to create a homogenous or heterogenous mixture and inverting the mixture in the
measuring cylinder for a predetermined number of times. The amount of persistent
foam created and remaining after certain periods of time is measured For example, a
"0.5% formulation" means that a homogeneous or heterogenous mixture comprising
0.5% by weight of the stable, self-dispersible. low foaming solid formulation is used
for assessing persistent foam.
The present invention provides a stable, self-dispersible, low foaming solid formulation
comprising:
(a) an effective amount of a pesticide;
(b) an effective amount of an anti-foaming agent: and
(c) an effective amount of an effenv'escent system.
In some embodiments, the oaming agent is a solid anti—foaming agent
The present invention provides a , self-dispersible. loxv foaming solid formulation
comprising:
(a) an ive amount of a pesticide;
(b) an effective amount of a solid anti-foaming agent; and
(c) an effective amount of an effervescent system,
wherein the formulation is ible with cold and/or hard water.
The present ion provides a stable, self-dispersible, low foaming solid formulation
comprising:
(a) an effective amount of pesticide;
(b) an effective amount of a liquid oil-based anti-foaming agent; and
(c) an effective amount of an effervescent system,
wherein the formulation is compatible with cold and/or hard water.
in an embodiment. the formulation is a stable, self-dispersible, low foaming solid
formulation comprising:
(a) at least one pesticide in an amount of 25-85% by weight based on the total
weight of the formulation;
(b) a solid anti-foamin5v arent in an amount of u5 P to l0% bv weight based on, _
the total weight of the formulation; and
(c) an effervescent system in an amount of at least 3—25% by weight based on
the total weight of the formulation:
wherein the formulation is compatible with cold and/or hard water.
ln an embodiment, the formulation is a stable. self—dispersible. low g solid
formulation comprising:
(a) at least one pesticide in an amount of 25-85% by weight based on the total
weight of the formulation;
(b) a liquid oil-based anti-foaming agent in an amount of up to 10% by weight
based on the total weight of the ation; and
(c) an effervescent system in an amount of 3-25% by weight based on the total
weight of the formulation:
wherein the formulation is compatible with cold and/or hard water.
in some embodiments. the liquid oil-based antifoaming agent is substantially free of
water. In some embodiments the liquid oil-based aming agent is free of water.
In some embodiments, the formulation further comprises an amount of a dispelling
system. In some embodiments. the amount of the dispelling system is up to 45% by
weight based on the total weight of the formulation. In some embodiments. the amount
of the dispelling system is more than 0.59/6 by weight based on the total weight of the
formulation. In some embodiments, the amount of the dispelling system is up to 25%
by weight based on the total weight of the formulation. In some embodiments, the
amount of the ling system is about 7.5% to about 16% by weight based on the
total weight of the formulation.
In some ments, the weight ratio of the effervescent system to the dispelling
system is from about 20:] to about 1:10. In some embodiments. the weight ratio of the
effervescent system to the dispelling system is from about 15:1 to about 1:1. preferably
from about 14:1 to about 1:1, more preferably from about 7:1 to about 1:1. In some
embodiments, the weight ratio of the effervescent system to the dispelling system is
about 1:1 to about 1:10, preferably from about 1:10 to about 1:5. In some embodiments.
the weight ratio of the effervescent system to the dispelling system is from 7:1 to 1:5.
in some embodiments. the weight ratio of the effervescent system to the dispelling
system is from about 1:2 to about 1:49. The weight ratio between the effervescent
system to the dispelling system is critical and influences the rate and amount of foam
formation.
in some embodiments, the weight ratio of the effervescent system to the dispelling
system is about I : .l .7. In some embodiments, the weight ratio of the effervescent system
to the ling system is about 1:4.9. In some embodiments. the weight ratio of the
effervescent system to the dispelling system is about 1:2. In some embodiments, the
weight ratio of the effervescent system to the dispelling system is about lzl. I. In some
embodiments. the weight ratio of the effervescent system to the dispelling system is
about 7: 1. In some embodiments, the weight ratio of the effervescent system to the
dispelling system is about Hz].
in a r embodiment, the pesticidal formulations have the advantage that the
antifoaming agent and the dispelling system are already in without the need to add
additional external components to the spray tank.
A self-dispersible formulation is advantageous also for soluble formulations.
In some embodiments, the effervescent system comprises an acid and a base, preferably
a weak acid and a weak base. r, the effervescent system that may be used with
the fonnulations bed herein is not limited to the combination of an acid and a
base.
Chemical reaction between an acid and a base can result in a rapid spontaneous
evolution of C02 gas when the effervescent system is combined with and wetted by
water. ln-situ formation ofgas enhances solid disintegration and/or particles dispersion.
Acids may include, but are not limited to, c and inorganic acids. The inorganic
acid may be a weak acid. Organic acids may include but are not d to carboxylic
acids such as citric acid, fumaric acid, phthalic acid, maleic acid, malic acid, oxalic
acid, adipic acid, glutaric acid, 2-methyl glutaric acid, succinic acid and tartaric acid or
any combination thereof.
Bases may include, but are not limited to, organic and inorganic bases. The inorganic
base may be a weak base. lnorganic base may e but are not limited to an alkali
metal carbonate or bicarbonate such as lithium carbonate, sodium carbonate, sodium
bicarbonate. potassium ate, potassium bicarbonate or any combination thereof.
in some embodiments, the dispelling system comprises at least one sing agent
and at least one wetting agent.
Dispersing agents may include, but are. not limited to, low-foaming surfactants.
Low-foaming surfactants include, but are not limited to, alkyl naphthalene sulfonate.
formaldehyde condensate, condensed methyl naphthalene sulfonate, sodium salt, fatty
alcohol ethoxylate, alkoxylated alcohol. silicone surfactant, hydrophobically d
polyacrylate, alcohol aikoxylates. lignosulphonates, and mixtures thereof.
Wetting agents may include, but are not limited to, sodium alkylnaphthalene sulphonate
sodium phenolsulphonic acid formaldehyde polycondensed. sodium lauryl sulfate,
polyalkoxylated butyl ether and polyaryiphenyl ether ate.
When mixing the present formulation with cold and/or hard water. there is a need to
disintegrate and disperse the resulting particles in order to enhance the suspensibility of
the les.
in some embodiments, the weight ratio of the dispersing agent to the wetting agent is
from about 1:10 to about 10:1. 1n another embodiment. the weight ratio of the
sing agent to the wetting agent is from about 1:2 to about 6:1. In some
embodiments, the weight ratio of the dispersing agent to the wetting agent is 1:2. In
some embodiments- the weight ratio of the dispersing agent to the wetting agent is 2:1.
in some embodiments, the weight ratio of the dispersing agent to the wetting agent is
in an embodiment. the molar ratio of the acid to the base in the formulation is 1:10 to
:1. 1n another ment, the molar ratio of acid to the base is from about 1:5 to
:1. In a c embodiment. the molar ratio of acid to the base is from about 1:2 to
2:1. In a specific embodiment, the molar ratio of the acid to the base is from about 120.5
to 1:6. In a specific embodiment, the molar ratio of the acid to the base is from about
1:15 to 1:4. In a specific embodiment, the molar ratio of the acid to the base is from
about l:l.5 to about 1:2.
In some embodiment. the amount of the effervescent system in the present formulation
is at least 1%, or 2%, or 3%, or 5%, or 10%, or 15%, or 20%, or 25%, or 30%, or 35%,
or 40% by weight based on the total weight of the formulation. In another embodiment,
the effervescent system is t in the ation in an amount of about 1-40% by
weight based on the total weight of the formulation. in r specific embodiment.
the amount of the escent system present in the formulation is between about 2 to
about 30% by weight based on the total weight of the formulation. In another specific
embodiment, the amount of the effervescent system present in the formulation is
between about 3 to about 30% by weight based on the total weight of the formulation.
in a further embodiment, the amount of effervescent system present in the formulation
is n about 5% to about 25% by weight based on the total weight of the
formulation. in a further embodiment, the amount of effervescent system present in the
formulation is between about 3% to about 25% by weight based on the total weight of
the formulation. In a further embodiment, the amowit of effervescent system present in
the formulation is between about 3% to about 5% by weight based on the total weight
of the formulation.
The present invention ses an antifoaming agent. which may be a liquid oil-based
antifoaming or a solid antifoaming agent. ln some embodiments, the anti-foaming agent
is not Rhodorsilx’ti'“ EP 6703, Geronol AF 80, or SAG 1538. Preferably, the antifoarning
agent is a silicon(e)-based antifoaming agent, it is well known that silicon(e)—based
antifoaming agents are prone to inactivation during granulation s, storage and in
electrolyte environments.
ln some embodiments, le antifoaming agents are required to withstand the
operating conditions of the extrusion process. In some embodiment. the antifoaming
agent is capable of anding temperatures greater than 50°C. In some embodiments,
the antifoaming agent is capable of withstanding temperatures r than 40°C. In
some embodiments, the antifoaming agent is capable of withstanding temperatures
greater than 35°C. Further, as the present formulation may be mixed with inorganic
salts such as fertilizers. the anti foaming agent suppresses the foaming ofthe formulation
in such a mixture.
In another embodiment, the amount of antifoaming agent in the formulation is 0.1%. or
02%, or 0.5%. or l%. 2%. 3%, 4%. 5%. 6% by weight based on the total weight of the
formulation.
In another embodiment. the amount of antifoaming agent in the formulation is about
0.1-3t % by weight based on the total weight of the formulation. In another
embodiment, the amount of antifoaming agent in the formulation is about 01-20% by
weight based on the total weight of the ation. in another specific embodiment.
the amount of antifoaming agent present in the formulation is between about 0.2 to
about 5% based on the total weight of the formulation. ln a ftuther embodiment, the
amount of antifoaming agent present in the formulation is between about 0.5 to about
% based on the total weight of the formulation. In yet a r embodiment. the
amount of antifoaming agent present in the formulation is between about 0.5 to about
% based on the total weight of the formulation. In yet another embodiment, the amount
of the antifoaming agent present in the formulation is about 0.2-5% by weight based on
the total weight of the formulation. In yet a further embodiment, the amount of
antifoaming agent present in the ation is between about 0.5 to about 2.5% based
on the total weight of the formulation. In yet a further embodiment. the amount of
antifoaming agent present in the formulation is between about 1% to about 2% based
on the total weight ofthe formulation.
In another embodiment. the amount of antifoaming agent in the formulation is less than
% by weight based on the total weight of the formulation.
Suitable non-limiting es of antifoaming agents that may be used in the present
formulations e but are not d to silicon(e) on r flowable powders. such
as for e polysiloxane on a neutral carrier. An example of a liquid oil-based
aming agent that may be used in the present formulations is a liquid based on
polydimethyl siloxane oil and silica. In preferred embodiments. the solid anti-foaming
agent is Silfoam® SP 150. Silfoam-R') SP 150 is a polysiloxane ne-based powder
antifoaming agent sold by Wacker Chemie AG.
In some embodiments. the solid antifoaming agent is added to a mixture comprising the
pesticide and the effervescent system before milling and granulation.
In another embodiment, the amount of the solid antifoaming agent in the present
formulation is at least 0.1%. 0.29/6, 0.5%, or 1%, or 5%, or 10%, or 15%, 20% or 309/1»,
by weight based on the total weight of the formulation. In another embodiment. the
amount of the solid aming agent present in the formulation is about 0.2-5% by
weight based on the total weight of the formulation. In another embodiment, the amount
of the solid antifoaming agent present in the formulation is about 1% to about 2% by
weight based on the total weight of the ation.
in another embodiment. the ammmt of the liquid oil-based antifoaming agent in the
present formulation is at least 0.1%. 0.2%. 0.5%, or 1%, or 5%. or 10%, or 15%, 20%
or 30%, by weight based on the total weight of the formulation. In r embodiment,
the amount of the liquid oil-based antifoaming agent present in the formulation is about
02-596 by weight based on the total weight of the formulation.
in some embodiments. the formulation is in powder form. In some embodiments, the
formulation is in granule form. In some embodiments, the formulation is in tablet form.
in some embodiments, the tablet is a soluble tablet. In some embodiments, the tablet is
a dispersible tablet. The Formulation may in the form of a water dispersible granule
(WDG). soluble granule (SG), wettable powder (WP) or a soluble powder (SP).
Preferably, the formulation is the form of a water dispersible granule.
In one embodiment, the pesticides are in the form of a solid.
Formulations of the present invention may se pesticides which have a melting
point of at least 70°C. at least 75°C, at least 80°C, at least 85°C. at least 90°C, at least
95°C or at least 100°C. ably, the pesticides of the present subject matter have a
melting point of at least 100°C.
The pesticides refer to fungicides. herbicides, insecticides, and nematicides, and any
combination thereof.
Fungicides may e but are not limited to strobilurins, phtalimides fungicides.
azoles fungicides or any combination thereof.
in specific embodiments, fungicides may include but are not limited to azoxystrobin.
buprofezin, Captan, , Folpet, chlorothalonil, cymoxanil, cyazofamid,
enzuron, omorph, lipronil. fosetyl aluminum, prochlorax. (zinc complex),
tebuconazole or any combination thereof.
Insecticides may e but are not limited to organochlorides. neonicotinoids,
pyrethroids avermectine, dinotefuran or any combination thereof.
in c embodiments. insecticide may e but are not limited to imidacloprid,
novaluron, pymetrozine, thiamethoxam, cartap, emamectin benzoate or any
combination thereof.
Herbicides may include but are not d to imidazolinones, sulfonylureas,
carbamates triazines or any combination thereof.
in specific embodiments, herbicides may include but are not limited to ne, DCPA.
nicosulfuron or any combination thereof,
in some embodiments, the pesticide is Captan. In some embodiments. the pesticide is
Folpet. In some embodiments, the pesticide is a ation of l-aluminum,
Folpet and dimethomorph. In some embodiments, the pesticide is a combination of
cartap and emamectine benzoate. In some ments. the pesticide is merpan. In
some embodiments. the pesticide is a combination of pymetrozine and dinotefuran.
in an embodiment, the amount of pesticides in the formulation are about 01-99 wt. %,
about 5 wt. %, or about 01-90 wt. %, based on the total weight of the formulation.
in a specific embodiment, the pesticides are present in a tration of at least 2096.
%. 40%. 5.0%. 60%. 70%. 80%. 90% by weight based upon the total weight of the
formulation. ln a specific embodiment, the pesticide is preferably present in a
concentration of at least 70% by weight, of at least 75% by weight, of at least 80% by
weight, of at least 85% by weight. of at least 90% by weight, of at least 95% by weight
based upon the total weight of the formulation. In an embodiment, the pesticides are
t in a concentration of about 70-95% based upon the total weight of the
formulation. in an embodiment. the pesticides are present in a concentration of about
40-95% based upon the total weight of the formulation. in an embodiment. the
pesticides are present in a concentration of about 25-85% based upon the total weight
of the formulation. In an embodiment. the pesticides are present in a concentration of
about 80~85% based upon the total weight of the formulation.
In some embodiments. the present formulation further ses a wetting agent.
Non-limiting es of wetting agents used in the present subject matter include low-
foaming surfactant for example sodium aphthalene sulphonate, sodium
phenolsulphonic acid dehyde potycondensed, sodium lauryl sulfate,
polyalkoxylated butyl ether and polyan'lphenyl ether phosphate.
In some embodiments, the amount of wetting agent in the formulation is about 01-15%
by weight based on the total weight ofthe formulation. In another specific ment.
the amount of wetting agent present in the formulation is between about 0.5 to about
12% based on the total weight ofthe formulation. in a further embodiment, the amount
of wetting agent present in the ation is between about 0.5 to about 6% based on
the total weight of the formulation. In a further embodiment. the amount of wetting
agent present in the formulation is between about 2.5 to about 4.5% based on the total
weight ofthe formulation.
In another ment. the amount of wetting agent in the formulation is less than 10%
by weight based on the total weight of the forn'tulation.
Wetting agents may include, but are not limited to, sodium aphthalene sulphonate
sodium phenolsulphonic acid formaldehyde polycondensed, sodium lauryl sulfate.
polyalkoxylated butyl ether and polyaiylphenyl ether phosphate.
In some embodiments. the formulation further comprises a dispersing agent.
Dispersing agents may include, but are not limited to. low-foaming surfactants.
Low-foaming surfactants include, but are not d to, alkyl naphthalene sulfonate
formaldehyde sate. alkoxylated alcohol, silicone surfactant, condensed methyl
naphthalene sulfonate. sodium salt. fatty alcohol ethoxylate, silicone surfactant,
hydrophobically modified polyacrylate, lignosulphonates and mixtures.
in some embodiments, the amount of dispersing agent in the formulation is less than
3( % by weight based on the total weight of the ation. in some embodiments, the
amount of dispersing agent in the formulation is less than 20% by weight based on the
total weight of the formulation. In another specific embodiment. the amount of
dispersing agent present in the formulation is between about 1 to about 20% based on
the total weight of the formulation. In a r embodiment. the amount of dispersing
agent present in the formulation is between about 2 to about 16% based on the total
weight of the formulation. In a further embodiment, the amount of dispersing agent
present in the formulation is between about 2.5 to about I 1% based on the total weight
of the formulation.
In some ments. the formulation further comprises a granulation aid agent. The
granulation aid agent works as a lubricant, s the friction in the granulation
process and results in reducing the temperature during granulation.
Granulation aid agents may include, but are not limited to. polyethylene glycol and
polypropylene glycol alkylated polyalkoxylated glycol.
In some embodiments, the granulation aid agent is solid. In some embodiments, the
granulation aid agent is liquid. In some embodiments. the granulation aid agent may be
prepared as a solution in granulation water.
In another ment. the amowit of the granulation aid a(10ent in the ation is at
least , or 0.29/5, or 0.50/6. or 1%, or 1.5%, or 2%, or 2.5% by weight based on the
total weight of the formulation. In another embodiment, the amount of the ation
aid agent is less than 10% by weight based on the total weight of the formulation. In
another embodiment. the amount of the granulation aid agent is about 2% by weight
based on the total weight of the formulation.
In some embodiments, the ation further ses additives. In some
embodiments. the formulation further comprises fillers. In an embodiment, the filler is
a solid filler. In some embodiments. the formulation further comprising an
agriculturally acceptable carrier.
In some embodiments. the formulation further comprises buffers, drying agents.
processing agents, adjuvants, safeners, adhesives. neutralizers. binders. sequestrates.
stabilizers. antioxidants or mixtures thereof.
In some ments, the buffer is citrate, phosphate, e. or mixtures thereof. In
some embodiments, the drying agent is sodium aluminosilicate. In some embodiments,
the processing agent is amorphous silica, fumed silica or mixtures thereof.
In a r embodiment, the pesticidal agricultural formulation discussed herein is an
agrochemical formulation comprising:
(a) at least one pesticide in amount of at least ot‘25-85% by weight based on
the total weight of the formulation;
(b) 3 solid aming agent in an amount of 0.5%-30% by weight based on
the total weight of the formulation; and
(c) an effervescent system in an amount of 3-25% by weight based on the total
weight of the formulation.
ln a further embodiment, the pesticidal agricultural formulation discussed herein is an
agrochemical fomiulation comprising:
(a) at least one ide in amOtmt of at least of 25—85% by weight based on
the total weight of the formulation;
(b) a liquid oil-based antifoaming agent in an amount of 0596-3094) by weight
based on the total weight of the formulation: and
(e) an effervescent system in an amount of 345% by weight based on the total
weight of the formulation.
The present invention further provides a , self-dispersible, low foaming solid
formulation comprising:
a) at least one pesticide;
b) an effective amount of solid anti-foaming agent; and
c) an effective amount of effervescent system.
The present invention further provides a stable. self-dispersible, low foaming solid
ation comprising:
a) at least one pesticide;
b) an effective amount of liquid oil-based anti-foaming agent; and
c) an effective amount of effervescent .
The present invention r provides a stable, self-dispersible, low foaming solid
formulation comprising:
a) at least one phthalimide fungicide;
b) an effective amount ot‘a solid anti-foaming agent: and
c) an effective ammmt of effervescent system.
The present invention further provides a , self-dispersible, low foaming solid
formulation comprising:
a) at least one phthalimide fungicide;
b) an effective amount of a liquid oil-based anti-foaming agent; and
c) an ive amount of effervescent system.
The t invention provides a stable, self—dispersible, low foaming solid formulation
comprising:
a) an effective amount of pesticide:
b) an effective amount of a solid anti-foaming agent;
0) an effective amount of ling system; and
d) an effective amount of effervescent .
wherein the formulation is compatible with cold and/or hard water.
The present invention provides a stable. self-dispersible, low foaming solid formulation
comprising:
a) an effective amount of pesticide;
b) an effective amount of a liquid oil-based anti-foaming agent;
c) an effective amount of dispelling system; and
d) an effective amount of effervescent system.
wherein the formulation is ible with cold and/"or hard water.
The present invention provides a stable, self-dispersible. low foaming solid
formulation comprising:
a) at least one pesticide in an amount of 25-85% by weight based on the total
weight of the formulation;
b) 21 solid oaming agent in an amount of up to 10% by weight based on
the total weight of the formulation;
c) dispelling system in an amount of up to 45% by weight based on the total
weight of the ation, and
d) an effervescent system in an amount of 3-25% by weight based on the total
weight of the formulation,
wherein the ation is compatible with cold and/or hard water.
The present invention provides a stable. self-dispersible. low foaming solid
formulation sing:
a) at least one pesticide in an amount of 25-85% by weight based on the total
weight of the formulation;
b) a liquid oil-based anti-foaming agent in an amount of up to 10% by weight
based on the total weight of the formulation;
a dispelling system in an amount of up to 45% by weight based on the total
weight of the formulation, and
d) an effervescent system in an amount of 3-25% by weight based on the total
weight of the formulation,
wherein the formulation is compatible with cold and/or hard water.
The present invention further provides a stable, self-dispersible. low foaming solid
formulation comprising:
a) at least one pesticide
b) an effective amount ofa solid anti-foaming agent:
C) a ling system in an amount of up to 45% by weight based on the total
weight of the formulation; and
d) an effective amount of effervescent system.
The present invention further provides a stable, ispersible, low foaming solid
formulation comprising:
a) at least one pesticide
b) an effective amount of a liquid oil-based anti-foaming agent;
c) a dispelling system in an amount of up to 45% by weight based on the total
weight of the formulation; and
d) an ive amount of escent system.
The present invention further provides a stable, self-dispersible, low foaming solid
formulation comprising:
at least one phthalimide fungicide;
an effective amount of a solid anti-foaming agent:
a dispelling system in an amount of up to 45% by weight based on the total
weight ofthe formulation; and
d) an effective amount ofetfervescent system.
The present invention further provides a stable, ispersible, low foaming solid
formulation comprising:
a) at least one phthalimide fungicide;
b) an effective amount of a liquid oil-based anti-foaming agent;
c) a dispelling system in an amount of up to 45% by weight based on the total
weight of the formulation; and
d) an effective amount ofeffervescent system.
in an embodiment of the present invention. the formulation further comprises a.
granulation aid agent.
in an embodiment of the present invention, the formulation further comprising a solid
filler and/or an agriculturally acceptable carrier.
In some ment, the granulation aid agent can be prepared as a solution prior to
granulation.
Other ingredients. such as adhesives, neutralizers, binders. sequestrates, stabilizers.
buffers and/or antioxidants, may also be added to the present formulations in order to
increase the stability, of the described formulations.
Fertilizers that are compatible with the present formulation are generally olytic
and may he refers but not limited to m chloride, m nitrate, magnesium
de, magnesium nitrate. ammonium e, um sulfate. anhydrous
a, calcium nitrate/urea, oxamide, potassium nitrate, urea, urea sulfate,
ammoniated superpliosphate, diammonium phosphate, nitric phosphate, potassium
carbonate. potassium osphate. calcium chloride. magnesium ammonium
phosphate, magnesium sulfate. ammonium sulfate, potassium sulfate. Such fertilizers
are known to those of ty skill in the art.
The present formulation is also substantially compatible with micronutrient
formulations containing elements such as boron, , copper, iron, magnesium,
molybdenum, potassium. sodium, sulfur and zinc ions.
Due to the electrolytic nature of the fertilizer. when the formulations discussed herein
are mixed with fertilizers, the resulting highly electrolytic mixture may become
inhospitable to certain components ofthe formulation. As such, each ofthe components
of the abovementioned formulation shall be compatible in an electrolyte water solution.
The agricultural formulations herein may be mixed with water and/or fertilizers and
may be applied ergence and/or post-emergence to a desired locus by any means,
such as airplane spray tanks, knapsack spray tanks. cattle dipping vats. farm equipment
used in ground spraying (cg. boom Sprayers. hand Sprayers), and the like. The desired
locus may be soil, plants, and the like.
As used in the present methods, the formulations sed herein may be d
jointly or in a succession with a fertilizer. That is, the pesticidal formulation and a
fertilizer may be applied jointly or in succession.
Further. the agricultural formulations herein may be used in conjunction with one or
more other pesticides to control a wider variety of undesirable pests. When used in
conjunction with other pesticides, the herein described formulation may be ated
with the other pesticide/s, tank mixed with the other pesticide/s or applied tially
with the other pesticide/s. In addition, the herein described formulation may. optionally,
be ed with or blended with other ide formulations. This blend of pesticides
may be used to control pests in crops and op environments.
The present formulation may include additional crop protection agents, for example,
bio-stimulants, molluscicides. growth regulators, biological agents. fertilizers, or
mixtures thereof. When used in conjunction with additional crop protection , the
formulation can be formulated with these co-agents, tank mixed with the co—agents or
applied sequentially with the co—agents.
in some embodiments. the pesticidal formulation is stable when moisture present in the
air at less than 40% RH. In some embodiments, the formulation is stable when the
moisture present in the air is 40% RH or r than 40% RH. In some embodiments,
the formulation is stable when the moisture present in the air is from 40% RH to 50%
RH. In some embodiments, the formulation is stable when the re present in the
art is from 50% RH to 60% RH.
In some embodiments. the pesticidal formulation is stable when stored for at least 2
weeks at a ature of 54°C.
According to an embodiment, the pesticidal formulation may readily disperse in hard
water. In some embodiments. the water has a hardness of 120-1000 ppm of calcium
carbonate. In some embodiments, the water has a hardness of 180-1000 ppm of calcium
carbonate. in some embodiments. the water has a hardness of 300-] 000 ppm ofcalcium
carbonate.
According to an ment. the pesticidal formulation may readily disperse in cold
water. In some embodiments, the cold water has a temperature of less than 9°C. in some
embodiments, the cold water has a temperature of 5-9°C. In some embodiments, the
cold water has a ature of 2-8°C. In some ments. the temperature of the
cold water may be as cold as 4—6°C or less than 4°C.
Formulations of the present subject matter may be processed using an ion
processing. Altematively. one or more ofthe following methods may be used to process
the formulation: (l) mixing eration, (2) pan or drum granulation, (3) fluid bed
granulation.
in an embodiment, the herein disclosed formulation has improved dispersion properties.
In some embodiments. the pesticidal formulation disperses in less than 10 minutes,
preferably in less than 5 minutes, and more preferably the pesticidal formulation
disperses instantly upon contact with water, including hard and/or cold water.
The present invention also es a package comprising any one of the formulations
described herein, wherein the package is impermeable to moisture. As used herein, the
term “impermeable" when used to characterize a package means that the package is
sufficiently impermeable to moisture such that the effervescent system comprised in
the formulation contained in the package does not substantially react when the package
is exposed to humid air. For example, the package may be made of um
metallized film laminates.
Preparation of the dispersible stable formulation
The present invention yet further provides a method of ing a stable, self-
dispersible, low foaming solid formulation comprising a solid anti-foaming agent.
n the method comprises:
(i) mixing an ive amount of ide, an effective amount of the solid
anti-foaming agent. and an eifervescent system; and
(ii) granulating the mixture to obtain granules.
In some embodiments, the method further comprises mixing an amount of a dispelling
system during step (i).
The present invention provides a cturing process of a stable. self-dispersible,
low foaming solid formulation comprising a solid anti—foaming agent, wherein the
manufacturing process comprises:
(i) mixing an effective amount of a ide, an effective atnount of the
solid oaming agent and an effective amount of an escent
system; and
(ii) granulating the mixture to obtain granules.
The present invention yet further es a manufacturing process of a stable, self-
dispersible, low foaming solid ation comprising a solid anti-foaming agent,
n the manufacturing process comprises:
(i) mixing an ive amount of a pesticide, an effective amount of the solid
anti-foaming agent, dispelling system and an effective amount of
effervescent system; and
(ii) granulating the mixture to obtain granules.
The present invention yet further provides a method of preparing a stable, self-
dispersible, low foaming solid formulation comprising a liquid oil-based anti—foaming
agent, wherein the method comprises:
(i) mixing an effective amount of pesticide and an effervescent system:
(ii) granulating the mixture to obtain granules; and
(iii) applying an effective amount of the liquid oil-based anti-foaming agent to
the obtained granules.
The present invention also provides a manufacturing process of the formulations of the
present invention comprising a liquid anti-foaming agent, n the process
comprises:
(i) mixing an effective amount of a pesticide and an effective amount of an
effervescent system;
(ii) granulating the mixture to obtain granules; and
(iii) applying an effective amount of the liquid oil—based anti-foaming agent to
the obtained granules.
The present invention yet further provides a cturing process for a stable, self-
dispersible. low g solid formulation comprising a liquid oil-based oaming
agent, wherein the manufacturing process comprises:
(i) mixing an effective amount of pesticide, a dispelling system and an effective
amount of an effervescent system;
(ii) granulating the mixture to obtain granules; and
(iii) applying an effective amount of the liquid oil-based anti-foaming agent to
the obtained granules.
In some embodiments, the effective amount of the liquid oil-based anti-foaming agent
is applied to the obtained granules and is ed onto the surface of the granules, In
some embodiments, the ive amount of the liquid oil-based anti—foaming agent is
applied to the obtained granules and forms a liquid layer over the surface of the
granules.
In some embodiments. the effective amount of the liquid oil-based anti-foaming agent
is applied by spraying.
The present invention yet further provides a method of preparing a , self-
dispersible, low g solid formulation comprising a solid anti-foaming agent.
wherein the method comprises:
(i) mixing an effective amount of ide. an effective amount of the solid
anti-foaming agent, and an effective amount of an effervescent system; and
(ii) milling the mixture to obtain powder.
Lo.) '4)
In some embodiments, the method further comprising mixing an amount of a dispelling
agent during step (i),
The present invention provides a manufacturing process of a stable. ispersible,
low foaming solid formulation comprising a solid anti—foaming agent, wherein the
manufacturing process comprises:
(i) mixing an effective amount of a pesticide, an effective amount of the solid
oaming agent and an effective amount of an effervescent system; and
(ii) milling the e to obtain .
The present invention yet further provides a manufacturing process of a stable, self-
dispersibie, low foaming solid formulation comprising a solid anti-foaming agent.
wherein the manufacturing process comprises:
(i) mixing an effective amount of a pesticide, an effective amount of the solid
anti-foaming agent, dispelling system and an ive amount of
effervescent system; and
(ii) g the mixture to obtain powder.
in some embodiments. the process further comprises a step of milling of the mixture of
step (i) to the desired particle size distribution prior to performing step (ii). In some
embodiments, the desired particle size distribution is D(90)<35 microns. In some
embodiments, the desired particle size distribution is D(90)<26 microns. in some
embodiments, the desired particle size distribution is D(90)<22 microns. In some
embodiments, the desired particle size distribution is D(90)<2() microns. In some
embodiments. the desired particle size bution is D(‘)O)< 19 microns.
in some embodiments, the cturing process comprises further mixing a dispelling
system with the mixture of step (i) prior to performing step (ii).
In some embodiments, the dispelling system comprises at least one dispersing agent
and at least one g agent.
In some ments, the weight ratio of the escent system to the dispelling
system is from about 20:1 to about 12l0. In some embodiments, the weight ratio of the
effervescent system to the dispelling system is from about 15:1 to about 1:1, preferably
from about 14:1 to about 1:], more preferably from about 7:1 to about 1:1. In some
ments, the weight ratio of the effervescent system to the dispelling system is
about 1:1 to about 1:10, preferably from about 1:10 to about 1:5. preferable from 7:1 to
l :5. In some embodiments. the weight ratio of the effervescent system to the dispelling
system is from about 1:2 to about 1:4.9. The weight ratio between the effervescent
system to the ling system is critical and influences the rate and amorutt of foam
formation.
In some embodiments, the weight ratio of the escent system to the dispelling
system is about H .7. In some embodiments. the weight ratio ofthe effervescent system
to the dispelling system is about 124.9. 1n some embodiments, the weight ratio of the
effervescent system to the dispelling system is about 1:2. In some embodiments, the
weight ratio of the effervescent system to the dispelling system is about 1:1.]. In some
embodiments, the weight ratio of the effervescent system to the dispelling system is
about 7:1. In some embodiments, the weight ratio of the effervescent system to the
dispelling system is about 1.1:].
in some embodiments. the manufacturing process comprises further mixing a
dispersing agent with the mixture of step (i) prior to performing step (ii). In some
embodiments. the process comprises further mixing a wetting agent with the e
of step (i) prior to performing step (ii). in some embodiments, the process further
comprises adding a granulation aid agent to the mixture of step (i).
in some embodiments, the ide is milled prior to performing step (i).
1n some embodiments, the method or manufacturing process further comprises a step
of ssing the obtained granules or powder to obtain a tabiet. In some
embodiments, the method or manufacturing process further comprises a step of
compressing the obtained granules to obtain a tablet. In some embodiments, the method
manufacturing process further comprises a step of compressing the ed powder of
to obtain a tablet.
Methods of Use
The formulations described herein are suitable for the control of undesirable vegetation,
Lo) ‘JI
fungal pathogens, ia, insects or nematodes. Methods of using the pesticidal
formulations of the subject invention include adding the pesticidal formulation to a
carrier such as water and using the resulting dispersion or solution containing the
pesticidal formulation for spray applications to control the undesirable vegetation,
fungal pathogens, ia or s in crop or non-crop environments.
Effective application rates of the pesticidal formulation cannot generally be defined, as
it varies depending upon various conditions such as the type of pesticide. target pest.
weather conditions, and the type of crop.
In an embodiment. the formulation is d in a carrier at rate from about 1 to 100kg
of the pesticidal formulation per IOOOL of the carrier. In a further embodiment, the
formulation is diluted in a r at a rate from about t to 30kg of the pesticidal
formulation per 10001. of the carrier. In yet another embodiment, the formulation is
d in a carrier at a rate from about 5 to l5kg of the pesticidal formulation per 1000L
of the carrier. In an embodiment. the carrier is water.
In some embodiments, the formulation is applied with a fertilizer. In some
ments, the formulation is tank mixed with the fertilizer. In some embodiment.
the formulation is applied sequentially with the fertilizer.
In an embodiment, the fertilizer is d in a carrier at a rate from about 1 to 100 kg
per 10001. of the carrier. In a further embodiment, the fertilizer is diluted in a r at
a rate from about i to 30 kg per l000L of the carrier. In yet another embodiment, the
fertilizer is d in a carrier at a rate from about 2 to 20 kg per [000L of the carrier.
In some embodiments, the carrier is water.
Preparation and Application of the End Use Composition
The present invention also provides an end use composition of the ation
described herein.
The end use composition of the present invention can be obtained by diluting the
formulation described herein with a can‘ier such as water.
The solid formulation may be added to the tank after water is added.
The solid formulation may be added to the tank by washing the formulation over a mesh
which is placed on the tank.
The present ations are diluted with water before use to produce an aqueous
composition which is used in crop protection. ln some embodiments. the aqueous
composition which is used in crop protection is a solution. In some embodiments, the
aqueous composition which is used in crop protection is a dispersion.
In some embodiments, the end use ition is a solution. In some embodiments.
the end use composition is a sion.
in some embodiments the formulation is wetted to form suspension concentrate
formulation prior to dilution.
In some embodiments the formulation is wetted to form concentrated liquid formulation
prior to dilution.
Each ment disclosed herein is contemplated as being applicable to each of the
other disclosed embodiments. Thus, all combinations of the various elements bed
herein are within the scope of the invention. In addition. the elements recited in
formulation embodiments can be used in the method, process and use embodiments
described herein and vice versa.
EXAMPLES
Formulation Example l
One exemplary embodiment of the ation is illustrated in Table 1. below:
TABLE l
Captan
SupragilR \1NS'90
Sodium bicarbonate
m® SP 150
ETHYLAN® NS 500 LQ 30
This formulation was prepared by mixing the Captan with SupragilQ?) MNS/90,
Supragil-E- WP, citric acid. sodium bicarbonate and Silfoam-R‘ SP 150 in a mixer until
the powders dispersed homogeneously. The premix was then milled until a particle size
bution of d90<22 micron was achieved. A portion of the premix was milled with
a Micronizer jet mill and a second portion was milled with a centrifugal mill.
The milled premix was wetted with granulation water containing 9% of E'l‘HYl..AN®
NS 500 LQ in a mixer. The wetted powder was extruded in an extrusion granulator
through 0.8-2 mm screen and the granules were dried in fluidized bed dryer. The dried
granules were then sieved.
The formulation demonstrated good dispersibility and low foaming under the ing
field application conditions: hard water (water (D) 342 PPM), cold water temperature
(5-9°C) and mixing with up to 15 kg fertilizers 110001.; fertilizers contained calcium
(for example Fertilizer Ca(:NO3)2 — Calcinit -: l9%; CaO: . Results are
presented in Tables 2-3.
TABLE 2
. Stor't e at
Normal Before ‘ g
Storage at 54°C
Parameters
lelts. . room
Storage. for 2 weeks
temperature
Yellowish Yellowish Yellowish
’ P”\ earan ‘eL
breakable breakable breakable
granules granules granules
(aptan
762 762
concentration 2 766
pH( l 0/0)
Persistent foam
(0 5%)(Temp=5°C)
Wet Sieve Residue
(10% 45um)
- =5°C)
Suspensibility
(0.5%
Wettabllity
(Tem=5°C
TABLE 3
Results from sprav tank test
_*g~SeseweeAmountof 5 k
ation g
Amount of 15 kg Ca(N03)2 15 kg La(l\()3)2N. 1
tem e
.‘0 O
W'ashing
108 liter
volume
Washmg ratio
1; 2 1
oaming No foaming observed No foaming observed
Clem — no residues
filter ‘ Clean — no resrdues observed.
observed
.. Clean — no residues
Sieve basket Clean no residues observed
observed
No clogging of the nozzles No clogging of the nozzles
nozzles. ‘
observed observed
ation Example 2
One exemplary embodiment of the ation is illustrated in Table 4, below:
TABLE 4
Folpet 800 Kg (l 00%)
Agriiane 789 25
Supragil® WP
Citric acid
Sodium bicarbonate
Silfoam® SP 150
ETHYLAN-RL- NS 500 LQ
This formulation was prepared by mixing the Folpet with Agrilan® 789, Supragil®
WP, citric acid. sodium bicarbonate and Silfoam-E SP 150 in a mixer until the powders
dispersed homogeneously. The premix was then milled until a le size distribution
l 9 micron was achieved. A portion of the premix was milled with a izer
jet mill and a second portion was milled with a fugal mill. The type of milling had
no impact on the results detailed herein below.
The milled premix was wetted with granulation water containing 4.5% of ETHYLANE
NS 500 1.0 in a mixer. The wetted powder was extruded in an extrusion granulator
through 0.3-2 mm screen and the granules were dried in fluidized bed dryer The dried
granules were then sieved.
The formulation demonstrated good dispersibility and low foaming under the following
field application conditions: hard water (water (D) 342 PPM), cold water temperature
(59°C) and mixing with up to 15 kg fertilizers flOOOL; fertilizers contained Calcium
(for example izer Ca(NO3)2 Calcinit ((3a”; 19%; (3:10: 265%). Results are
presented in Tables 5-6.
TABLE 5
Storage at room temperature Storage at 54°C for 2. weeks
White breakable granules White ble granules
79.2% ( .
pI-l(l%) 9.4
Persistent foam
Wet Sieve Residue (10%.
45 tm Tem ===5°C
Conditions Stora e at room temerature Storage at 54°C for 2 weeks
Yellowish breakable
Appearance Yellowish breakable granules
granules
Folpet Concentration (96) 79.2%
wa vbt (k ,)
Persistent Foam (1%,
°C No g observed No foaming. ed
No clogging of the nozzles No clogging of the nozzles
Nozzles..
observed observed.
Formulation Example 3
One exemplary embodiment of the formulation is illustrated in Table 7, below:
TABLE 7
Fosetyl-Aluminum 500 Kg (100%)
Folpet 250 Kg (100%)
Dimethomorph 50 Kg (1009’ )
Berol 08 20
Supragil® WP
Citric acid 25
Sodium bicarbonate
Silfoamait) SP 150
ETHYLAN® NS 5001.0
This formulation was prepared by mixing the foseu’l-aluminum, Folpet and
omorph with Berol 08, Supragil® WP, citric acid, sodium bicarbonate and
Silfoam® SP 150 in a mixer until the powders dispersed homogeneously. The premix
was then milled until a particle size bution of d90<19 micron was achieved. A
portion of the premix was milled with a Micronizer jet mill and a second portion was
milled with a fugal mill. The type of milling had no impact on the s detailed
herein below.
The milled premix was wetted with granulation water containing ETl-1YLAN®
NS 5.00 LQ in a mixer. The wetted powder was extruded in an extrusion granulator
through 0.8-2 mm screen and the granules were dried in fluidized bed dryer. The dried
granules were then sieved.
The formulation demonstrated good dispersibility and low foaming under the following
field application conditions: hard water (water (D) 342 PPM), cold water temperature
(5-9°C) and mixing with up to 15 kg fertilizers /1000L; fertilizers contained Calcium
(for example Fertilizer Ca(NOs)2 Calcinit ((3a”: 19%; (3210: 26.5%). Results are
presented in Tables 8-9.
TABLE 8
Test Normal Limits Initial Results Final Results
Appearance Off—white granules Offlwhite it?
= mules
E.................................................... ........................................... . .............s. .............. ...........granules............
Fosetyl-Altmiinum
. 47.5 52. 5% 51.1% 51.1%
concentration
Folpel tration 23.75 - 26.25%
Dimethomorph 4 5 5.5 %
concentration r
pH (1% in water) 2.5---4.o
Wettability (10%) ‘
<, .30
°C) '
Wettability (10%)
_ : (so
(roomtuniwamre1
Persistent Foam Mama) m1 afterl
(3% 5°C min.
Persistent Foam
Maxéo ml after 1
( %) (room
temierature
Sieve test Residue <1%
Particle Size D(90)
. 22_35
m 2
TABLE 9
Results from spray tank test
Amount of ation 3.35 kg
% formulation 3%
Wash water temperature 3°C
tank temperature 15°C
Washing volume 40 liter
Washing ratio (W/L) 1:12
foaming No foaming observed
filter Clean — no residues observed
Sieve basket Clean — no residues observed
nozzles No clogging of the nozzles observed
Formulation Example 4
One exemplary embodiment of the formulation is illustrated in Table l0, below:
TABLE l0
250 Kg
Cartap HCl Tech.
261 K v for 96.0%
. [0 Kg
Emamectme Benzoate Tech..
ll K , for 910%
Supragm'lw"
Sodium bicarbonate
Silfoam® sp 150
E'l‘HYLAN'J?) NS 500 LQ
‘ ‘ Up to 1000 kg
1. Stage A: Preparation of Premix:
The Canap l-lCl Tech. and the Emamectine Benzoate Tech. were mixed with
Supragilfli; WP, citric acid. sodium bicarbonate. Silfoamik‘: SP 150. lonol® CP and
lactose to prepare the premix. The premix was milled to particle size distribution of
d90<20 micron.
2. Staoe B: Granulation:
The premix was wetted with approximately 13% granulation water contained 4% of
LANQ?) NS 500 LQ (as usly prepared on). Extrusion granulation
through 0.8 mm screen was performed and the granules were dried in fluidized bed
dryer. The dried granules were sieved.
Stability test results for this formulation is summarized in Table 11, below:
Table l l
Normal Initial
Limits ; Final Results
Results
Yellowish
Appearance White White
‘ breakable
granules granules
granules
23.0 27.0
Cartap l-lCl conc.
Emamectin te
(IS—1.2%,
a cone.
pH(l%) 3 o
Less then 5 Less then 5
Wettability
Persistent foam E ()0 ml : 8ml
0.5% after 1 min.
WSR (10%, 45pm)
Dilution Stabilityafter
minutes
Dilution Stability-
after 18 hours
Formulation Example 5
One exemplary embodiment of the formulation is illustrated in Table 12, below:
Table 12
500 Kg
Merpan tech.
532 K0 for 94.0 %
Agrilan 789 (hydrophobically 5
modified polyacn'late" c 20 Kg
Co olvmer 5
Supragil® WP (sodium
Diisopropylmmhrhalenesulphw-z 25 Kg
Morwet D-SOO (sodium salt of
naphthalene sulfonate
condensate (NSC) with block
.......copolymer)._.. .._......i.............._._..._..._..............._._..._...L.~.~....._._..........“a.....................................J
Ufoxane 3A (Sodium
Kg
[i nosu! )honale :
Ammonium e 78.5 Kg
Sodium bicarbonate 78.5 Kg
Silfoam® SP 150 (P()Li'siloxcinr:
Silicone-basedpowder amt/22am 20 Kg
a_ em)
Ethylandsl NS 500 LQ (non-
ionic surfactant. 15.0 Kg
olvalkoxvlated butvl ether)
Up to 1000 kg
Com Starch
about 121.0 k .
Table 13
Appearance Light brown granule
Bulk density
PSD Dam)“
This formulation was prepared by mixing the merpan with Agrilanig‘z 789. Supragil®
WP, Morwet D500. Ufoxan 3A, ammonium sulfate. sodium bicarbonate, corn starch
and Silfoam® SP 150 in a mixer until the s dispersed neously. The
premix was then milled tuitil a particle size distribution of d90<l9 micron was
ed. A portion of the premix was milled with a Micronizer jet mill and a second
portion was milled with a centrifugal mill. The type of milling had no impact on the
results detailed herein below.
The milled premix was wetted with granulation water containing 4.5% of‘ETHYI..AN®
NS 500 LQ in a mixer. The wetted powder was extruded in an extrusion granulator
through 0.8-2 mm screen and the granules were dried in ed bed dryer. The dried
granules were then sieved.
Formulation Example 6
One exemplary embodiment of the formulation is illustrated in Table 14, below:
Table 14
_ 293 Kg
P) metrozme tech._
298 K for 98.0 %
D'“°‘efi““"‘e°“__m.m_m_m.1L1233519L2§4139_______________
Ufoxane 3A (Sodium lignosulphonate)
Agrilanfli} 789 (hydrophobically modified
olvac 'late/ Acrvlic Cool rmer
Supragilriizh WP (sodium
Diiso ro vlna hthalenesul honate
Silfoamiii; SP 150 (Polysiloxane Silicone-
owder am agent
Ammonium sulfate
Sodium bicarbonate
Aerosil 150
(Silicon dioxide, ally prepared)
Tixosil 43 (Precipitated silica)
Break-THRU S 240
Polvether-modified olvsiloxane
Atlox 4913 - (l-lydrophilic methyl
methacvlate rafi co . olvmer
Emulsogen TS 540 (2,4.6-‘I‘ri-(l-
phenylethyl)-phenol polyglycol ether with S4
DOW PAC ULV Polyanionic Cellulose
Polvmer
‘ Up to 1000 kg
Table 15
Pymetrozine conc
Dinotefuran conc
11-10%)
Persistent foam (0.0 .%;0.3 %)
WSR (10%, 75um) >98%
Suspensibility (0.01%; 0.32%)
Wettability (10%)
gBiégéiéiiiii'i;""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""
Water content
* due to
use of Wmetrozine Di-hydrate in formulation, % water resulted
from the test is a bit higher than in usual formulations (part of Di—hydrate
water released)
Preparation procedure:
Stage A: Preparation of Milled Premix
This formulation was prepared by mixing the filinetroziiie Tech. and the furan
Tech. with e 3A, Agrilan-Ji} 789, il® WP, Silfoam-RL- SP 150, ammonium
sulfate, sodium bicarbonate, Aerosil 150. Tixosil 43, DOW PAC ULV and corn starch.
The premix was then milled until a particle size distribution of d90<l9 micron was
achiev ed.
Stage B: Preparation of hydratation solution
A ion solution ning 7.5% Break-Tl-IRU S 240, 7.5% Atlox 49l 3 and 7.5%
Emulsogen TS 540 and 775% water was prepared.
Stage C: Hvdratation and wetting
The milled premix from Stage A was wetted with 14% of hydratation solution from
Stage B (for 1000 kg premix, 140 kg hydratation solution). The premix was mixed for
s (the mixture heated to ~35°C), and allowed to cool for two hours
(minimum).
The premix was wetted with an additional ~10-12% of granulation water, extrusion
granulation through 1.2 mm screen was performed and the granules were dried in
zed bed dryer (Air temp. 65°C). The dried granules were sieved.
ation Example 7:
One exemplary embodiment of the formulation is illustrated in Table 16, below:
Table 16
500 Kg
MerPan “5°“_
(5.32 K2 for 940 %)
Agrilanft) 789 (hydrophobically
modified polyacrylate/ Acrylic 20 Kg
Co iolvmer
Supragiliic WP (sodium
Kg
Diiso m Vina hlhalenesul Mannie
Morwet D-SOO (sodium salt of
naphthalene sulfonate condensate 100 Kg
(NSC) with block co olvmer)
Ufoxane 3A (Sodium
Kg
li nosul honale'
Ammonium sulfate 78.5 Kg
Sodium bicarbonate 78.5 Kg
SILCOLAPSE’R) 416: liquid
antifoam based on polydimethyl 20 Kg
siloxane oil and silica
n’E NS 500 [Q — (non-ionic
surfactant, polyalkoxylated butyl 150 Kg
ether)
. Up to 1000 kg
Pregarafion grocedure:
1. Stage A: ation of Premix.
The Merpan tech. is mixed with Agrilanviiti- 789, Supragiliit‘; WP, Morwet D600, Ufoxane
3A. ammonium e, sodium bicarbonate and corn starch to prepare the premix. The
premix is milled to particle size distribution of d90<20 micron.
2. Stage B: Preparation of wetting solution.
IOO kg oi‘ETHYLAN-TE NS 500 LQ is dissolved in 8001, water to form a solution.
3. Stage C: Granulation of Mel-nan 78 WDG
The premix is wetted with wetting solution B. Extrusion granulation through 0.8 mm
screen is performed and the granules are dried in fluidized bed dryer. The dried granules
are sieved.
4. Stage D: Application: of liguid antifoaming agent
The dry granules are sprayed with 2% Sll.-COLAPSEJ§;z 416; liquid antifoam to form
the final fomrulation.
With the information ned herein, various departures from a precise description of
the present subject matter will be readily apparent to those skilled in the art to which
the t subject matter pertains, without ing from the spirit and the scope of
the below . The present subject matter is not to be considered d in scope to
the procedures, properties or components defined, since the preferred embodiments and
other descriptions are intended only to be rative of ular aspects of the
presently ed t matter. Indeed. various modifications of the described
modes for carrying out the present subject matter which are obvious to those skilled in
the art or related fields are intended to be within the scope of the following claims.
All publications, patents and patent applications mentioned in this specification are
herein incorporated in their entirety by reference into the specification, to the same
extent as if each individual publication, patent or patent application was specifically
and individually indicated to be incorporated herein by reference.
Claims (7)
1. A stable. self—dispersible. low foaming solid formulation comprising: (a) an effective amount of a pesticide; (b) an effective amount of an anti—foaming agent; and (c) an effective amount of an effen'escent system. The ation of claim l. wherein the anti-foaming agent is a solid anti- foaming agent. The formulation of claim 1 or 2. wherein the formulation further comprises dispelling system The formulation of claim 3, wherein the amount of the dispelling system is up to 45% by weight based on the total weight of the formulation. The formulation of claim 3 or 4. wherein the amount of the dispelling system is about 7.5% to about 16% by weight based on the total weight ofthe formulation. The formulation of any one of claims 3-5, wherein the dispelling system comprising at least one dispersing agent and at least one g agent. The formulation of claim 6, wherein the weight ratio of the dispersing agent to the wetting agent is from about l2l0 to about l0: 1. The formulation of claim 7, wherein the weight ratio of the dispersing agent to the wetting agent is about 2: l.
9. The formulation of any one of claims 6-8, wherein the dispersing agent is a low- foaming surfactant. It). The formulation of claim 9, n the low-foaming tant is selected from alkyl naphthalene sulfonate dehyde condensate, alkoxylated l, silicone surfactant. condensed methyl naphthalene sulfonate. sodium salt, fatty alcohol ethoxylate, hydrophobically modified polyacrylate, lignosulphonates, and mixtures thereof. ll. The formulation of any one of claims 6-10, wherein the amount ofthe dispersing agent is between about 2.5 to about 11% based on the total weight of the ation.
12. The formulation of any one of claims 6-11, wherein the wetting agents is selected from sodium alkylnaphthalene sulphonate sodium phenolsulphonic acid formaldehyde polycondensed, sodium lauryl sulfate, poly alkoxylated butyl ether, polyarylphenyl ether phosphate and mixtures thereof. The formulation of any one of claims 6-12. wherein the amount of the wetting agent is between about 2.5 to about 4.5% based on the total weight of the ation.
14. The formulation of any one of claims 3-13, wherein the weight ratio of the effervescent system to the dispelling system is from about 20:1 to about 1:10.
15. The ation of any one of claims 3-14. wherein the weight ratio of the effervescent system to the dispelling system is from about 1:2 to about 124.9.
16. The formulation of any one of claims 1-15, wherein the effervescent system is present in the formulation at an amount of 3 to 30% by weight based on the total weight of the formulation. l.
7. The formulation of claim 16. wherein the effervescent system is present in the formulation at an amount of 3 to 5% by weight based on the total weight of the ation
18. The formulation of any one of claim 1—17, wherein the effervescent system ses a weak acid and a weak base. The formulation of claim 18, wherein the acid is an inorganic weak acid or carboxylic acid selected from the group comprising of citric acid. fumaric acid, phthalic acid, maleic acid, malic acid. oxalic acid. adipic acid. glutaric acid, 2- methyl glutaric acid, succinic acid and tartaricacid and any combination thereof;
20. The formulation of claim 18 or 19, wherein the weak base is an alkali metal carbonate or onate selected from the group sing of lithium carbonate, sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and any combination thereof.
21. The formulation of any one of claims 18-20, wherein the molar ratio of the acid to the base is from about 120.5 to 1:6.
22. The formulation of claim 21, wherein the molar ratio of the acid to the base is from about 1: 1 .5 to 1:2.
23. The formulation of any one of claims 2-22, wherein the solid anti-foaming agent is silicon(e) on carrier llowable s.
24. The formulation of claim 2'3, wherein the silicon(e) on carrier flowable powders is polysiloxane on a neutral carrier. The formulation of any one of claims 1-24. wherein the antifoaming agent is tmaffected by temperatures greater than 35°C and are active in the presence of inorganic salts.
26. The ation of any one of claims 1-25, n the antifoaming agent is present in the formulation at a tration of 0.1. -30%, by weight based on the total weight of the formulation.
27. The formulation of any one of claims 1-26, n the antifoaming agent is present in a concentration of 0.26% by weight based on the total weight of the formulation.
28. The formulation of any one of claims 1-27. wherein the antifoaming agent is t in the formulation at a concentration of 1% to 2% by weight based on the total weight of all components in the formulation. The formulation of any one of claims 1-28, n the pesticide is selected from the group comprising of fungicides, insecticide. herbicide and nematicide and any ation thereof.
30. The formulation of any one of claims 1-29, wherein the pesticide is selected from the group comprising of azoxystrobin. buprofezin, Captan, chlorothalonil, cymoxanil, cyazofamid, diflubenxuron, dimethomorph, dinotefuran, fipronil. Folpet, fosetyl aluminum. imidacloprid, novaluron. prochloraz (zinc complex), pymetrozine, nazole. thiamethoxam, cartap, emamectin benzoate and any combination f.
31. The formulation of any one of claims 1-30. wherein the pesticide is present in the formulation at a concentration of about 25-95% by weight based on the total weight of the formulation.
32. The formulation of any one of claims l-3l, wherein the pesticides are t in a concentration of about 80-85% based upon the total weight of the formulation
33. The formulation of any one of claims 1-32, wherein the formulation further comprises an amount of a granulation aid agent.
34. The formulation of claim 33, wherein the granulation aid agent is liquid.
35. The formulation of claim 33 or 34. wherein the amount of the granulation aid agent is less than 10% by weight based on the total weight of the formulation.
36. The ation of any one of claims 33-35, wherein the amount of the granulation aid agent is about % by weight based on the total weight of the formulation.
37. The ation of any one of claims 1—36, wherein the formulation further comprises an amount of a dispersing agent and/or an amount of a wetting agent The formulation of any one of claims 1-37. wherein the formulation is in , granule or tablet form.
39. The formulation of any one of claims 1-38. wherein the formulation is in the form of a water dispersible granule, a wettable , a soluble granule, or a soluble powder.
40. The formulation of any one of claims 1—39, wherein the formulation is compatible with cold water.
41. The formulation of claim 40, wherein the cold water has a temperature of less than 9°C.
42. The formulation of any one of claims l-4l, n the formulation is compatible with hard water.
43. The formulation of claim42. wherein the hard water has a hardness of 120-1000 ppm of calcium carbonate.
44. The formulation of any one of claims 1-43, wherein the formulation is compatible with electrolytes. The formulation of claim 44, n the electrolytes are fertilizer and/or micronutrients.
46. The formulation of any one of claims 1-45, wherein the formulation further ses a fertilizer.
47. The formulation of any one ofclaims 1-46, wherein the formulation lacks a filler and an agriculturally acceptable carrier.
48. The formulation of any one of claims [—47 further comprising a buffer, a drying agent. a processing agent, an adjuvant, a r. an adhesive, a neutralizer. a binder, a sequestrate, a stabilizer, an antioxidant or any es f.
49. The formulation of claim 48, wherein: (a) the buffer is citrate, phosphate, acetate, or a mixture thereof, (b) the drying agent is sodium aluminosilicate, and/or (c) the processing agent is amorphous silica. fumed silica, or a mixture there-of. 5.0. A fertilizer ation comprising any one of the formulations defined in any one of claims l—49 and a fertilizer. Si. The fertilizer formulation of claim 50, wherein the fertilizer is selected from the group comprising of calcium de, calcium nitrate. magnesium chloride, ium nitrate, boron salts and a combination thereof.
52. The ation of claim any one of claims 45-51. wherein the micronutrient is zinc.
53. A solid formulation comprising: a) a fungicide or an insecticide in amount of at least 25% by weight based on the total weight of the formulation, b) an anti—foaming agent in amount ofat least 0.5% by weight based on the total weight of the formulation, and c) an effen'escent system in amount of at least % by weight based on the total weight of the formulation. The ation of claim 53, wherein the pesticide is a fungicide. The formulation of claim 54, wherein the fungicide is Captan or .
56. An end use composition comprising the formulation of any one of claims 1—55 and water.
57. The end use composition of claim 56, wherein the end use composition is a solution or a dispersion. A method of controlling or preventing a disease caused by phytopathogenic fungi on plants or propagation material thereof, comprising contacting the plants, the locus thereof or propagation material thereof with an effective amount of the formulation or end use composition of any one of claims 1-57. A method of controlling undesired vegetation comprising applying to a locus of the undesired vegetation an effective amormt of the formulation or end use composition of any one of claims 1-57i
60. A method for controlling unwanted s comprising ng to an area infested with said insects an effective amotmt of the formulation or end use composition of any one of claims 1-57.
61. The method of any one of claims 58—60, wherein the method further comprises application ofa fertilizer.
62. The method of claim 61, wherein the formulation and the fertilizer are applied jointly or in succession.
63. A method of preparation of a stable, self-dispersible, low foaming solid formulation comprising: (i) mixing an ive amount of pesticide, an effective amount of solid anti-foaming agent and an effervescent system; and (ii) granulating the mixture to obtain granules.
64. The method of claim 63. n the granules are compressed to obtain tablets. A method of ation of a stable. self-dispersible, low foaming solid formulation comprising: ( i) mixing an effective amount of pesticide. an effective amount of solid anti-foaming agent and an effervescent system; and (ii) milling the mixture to obtain powder.
66. The method of claim 65, wherein the powder is compressed to obtain tablets.
67. A e comprising the formulation of any one of claims 1-55, wherein the package is impermeable to moisture.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62/431,342 | 2016-12-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ794880A true NZ794880A (en) | 2022-12-23 |
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