NZ793836A - Injection device, in particular autoinjector, for the simultaneous administration of several medications - Google Patents
Injection device, in particular autoinjector, for the simultaneous administration of several medicationsInfo
- Publication number
- NZ793836A NZ793836A NZ793836A NZ79383617A NZ793836A NZ 793836 A NZ793836 A NZ 793836A NZ 793836 A NZ793836 A NZ 793836A NZ 79383617 A NZ79383617 A NZ 79383617A NZ 793836 A NZ793836 A NZ 793836A
- Authority
- NZ
- New Zealand
- Prior art keywords
- drive
- carrying housing
- piston rods
- autoinjector
- carpules
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims abstract 6
- 238000002347 injection Methods 0.000 title claims abstract 6
- 239000007924 injection Substances 0.000 title claims abstract 6
- 229940090047 Auto-Injector Drugs 0.000 title claims 19
- 230000004308 accommodation Effects 0.000 claims abstract 11
- 230000004913 activation Effects 0.000 claims abstract 6
- 239000002131 composite material Substances 0.000 claims abstract 5
- 241001631457 Cannula Species 0.000 claims 5
- 230000014759 maintenance of location Effects 0.000 claims 4
- 238000007789 sealing Methods 0.000 claims 3
- 150000002500 ions Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000004568 cement Substances 0.000 claims 1
Abstract
The invention relates to an injection device (1) for the simultaneous administration of several medications. The injection device (1) comprises a carrying housing (5), an activation sleeve (8) surrounding the carrying housing (5), at least two carpules (9,11), a first drive module (13) for the administration of the medications, a securing device (14), a needle arrangement (17), a needle protection element (20), and a second triggerable drive module (21) for the needle arrangement (17). The carpules (9, 11), seen in cross-section, are arranged next to another. The first drive module (13) comprises a drive element (22) with a number of piston rods (23, 24) equal to the number of carpules (9, 11), which form a composite structural unit. At least one of the piston rods (23, 24) is configured in the form of a hollow cylinder and is formed as closed on the piston side, wherein arranged inside this is a first drive means (26) of the first drive module (13). The first drive means (26) can be arranged in an accommodation part (27) of the drive element (22), seen in cross-section as arranged laterally next to the piston rods (23, 24), wherein the accommodation part (27) forms with the piston rods (23, 24) a composite structural unit. istration of the medications, a securing device (14), a needle arrangement (17), a needle protection element (20), and a second triggerable drive module (21) for the needle arrangement (17). The carpules (9, 11), seen in cross-section, are arranged next to another. The first drive module (13) comprises a drive element (22) with a number of piston rods (23, 24) equal to the number of carpules (9, 11), which form a composite structural unit. At least one of the piston rods (23, 24) is configured in the form of a hollow cylinder and is formed as closed on the piston side, wherein arranged inside this is a first drive means (26) of the first drive module (13). The first drive means (26) can be arranged in an accommodation part (27) of the drive element (22), seen in cross-section as arranged laterally next to the piston rods (23, 24), wherein the accommodation part (27) forms with the piston rods (23, 24) a composite structural unit.
Description
The invention s to an injection device (1) for the simultaneous administration of several
medications. The injection device (1) comprises a ng housing (5), an activation sleeve (8)
surrounding the carrying housing (5), at least two carpules (9,11), a first drive module (13) for the
administration of the medications, a securing device (14), a needle arrangement (17), a needle
protection element (20), and a second triggerable drive module (21) for the needle arrangement
(17). The carpules (9, 11), seen in cross-section, are arranged next to another. The first drive
module (13) comprises a drive element (22) with a number of piston rods (23, 24) equal to the
number of carpules (9, 11), which form a composite structural unit. At least one of the piston rods
(23, 24) is configured in the form of a hollow cylinder and is formed as closed on the piston side,
wherein arranged inside this is a first drive means (26) of the first drive module (13). The first drive
means (26) can be arranged in an accommodation part (27) of the drive element (22), seen in
cross-section as ed laterally next to the piston rods (23, 24), wherein the odation
part (27) forms with the piston rods (23, 24) a composite structural unit.
NZ 793836
INJECTION DEVICE, IN PARTICULAR AUTOINJECTOR, FOR THE
SIMULTANEOUS ADMINISTRATION OF SEVERAL MEDICATIONS
Incorporation by Reference
This application is a divisional application of New d Patent Application No.
753021, which is the New Zealand National Phase ation of
2017/077651 filed on 27 October 2017, which claims the benefit of Austrian
Patent Application No. A50987/2016 filed on 27 r 2016 and of United States
of America Provisional Patent Application No. 62/413,557 filed on 27 October 2016,
the disclosures of which are incorporated herein by nce in their entirety.
Field of the Invention
The invention relates to an injection device, in particular an autoinjector, for the
simultaneous administration of at least two medications.
Background of the Invention
From WO 52542 A1 a generically configured injection device is known, with a
distal end section and a proximal end section. The injection device can be
automatically moved from a storage setting into an injection position. The device
ses a carrying housing configured as a sleeve, which is designed as
subdivided into a front ng housing part and a rear carrying housing part, and
comprises a distal end and a proximal end. The carrying housing is surrounded over
most of its length by an activation sleeve, wherein the distal end of the ng
housing projects beyond the activation sleeve. In order to trigger the injection device,
the activation sleeve can be moved in the axial direction relative to the carrying
g. Arranged in the carrying housing are a carpule and a needle arrangement.
The carpule is in drive connection with a first drive module. By means of a securing
device, the first drive module is held firmly in its position in relation to the carrying
housing until its activation for the injection procedure. In addition, accommodated
inside the carrying housing is a needle arrangement with a cannula, wherein, in the
storage setting of the injection device, the needle arrangement is arranged in front of
the carpule in the section of the distal end. Both ends of the cannula are also
arranged inside the carrying housing. Also ed is a needle protection element,
with a second activatable drive module in drive connection with it, the drive module
moving the needle protection element from the non-effective on into the cover
position. When viewed in the axial direction the first drive module is arranged behind
the e, as a result of which more space is needed in the direction of the
longitudinal extension.
Summary of the Invention
The object of the present invention is to overcome the disadvantages of the prior art
and to provide an injection device that allows for a multiple carpule arrangement, as
well as allowing for a compact ural arrangement of the entire injection device.
This object is solved by an injection device in accordance with the claims. In
particular the present invention provides an injector device according to claim 1.
The injection device according to the invention, in particular an autoinjector, serves to
provide the simultaneous administration of at least two medications to a living being,
in ular a person, which or who is in an emergency situation or exceptional
ion. The injection device, configured here as an autoinjector, can be
automatically moved from a e setting into an injection position. The injection
device, which has a distal end n that can be directed s a patient and a
proximal end section that faces away therefrom, comprises:
- a ng housing, said carrying housing being configured in a sleeve shape and
comprising a distal end and a proximal end,
- an tion sleeve, said activation sleeve surrounding the carrying housing over a
predominant part of its longitudinal extension, starting from the proximal end in the
direction towards the distal end, wherein the distal end of the carrying g
projects beyond the activation sleeve, and the activation sleeve is moveable in an
axial direction relative to the carrying housing,
- at least one e, with a piston arranged in it, said piston being movable in the
axial direction, and with a tion received in the at least one carpule which is to
be administered during the injection procedure, and wherein the at least one carpule
is received in the carrying housing,
- a first drive module with a first drive means, said first drive module being in drive
connection with the at least one carpule, and the first drive module being activatable
by means of the activation sleeve,
- a securing device, said securing device holding the first drive module firmly in
position ve to the carrying housing until the activation of the first drive module for
the injection procedure,
- a needle arrangement with at least one cannula, said needle arrangement being
arranged in front of the carpule in the section of the distal end when in the storage
setting of the injection , and in each case with both ends of the at least one
cannula being arranged inside the carrying housing,
- a needle protection t, wherein when in the e setting of the injection
device, the needle position element is e from a release position into a cover
position, in which the needle end of the at least one cannula is covered, and wherein
said needle end projects over the distal end of the carrying housing after the ion
procedure,
- a second activatable drive module, with a second drive means, said second drive
module ed to move the needle protection element from a non-effective position
into the cover position,
- and further comprises at least two carpules wherein, when viewed in cross-section,
the at least two carpules are arranged next to one another in the carrying housing,
- wherein the first drive module further comprises a drive element, said drive element
being arranged inside the carrying housing,
- wherein the drive element comprises in each case a number of piston rods that is
equal to the number of carpules, said piston rods forming a composite structural unit,
- wherein at least one of the piston rods is configured in the form of a hollow cylinder
that is closed at a first end region facing towards the distal end section,
- wherein the first drive means is arranged in the hollow cylinder of the at least one
piston rod and/or
- wherein the first drive means is arranged in an accommodation part of the drive
element, such that, when viewed in cross-section, it is ed laterally next to the
piston rods, and whereby the accommodation part forms a composite structural unit
with the piston rods.
The advantage thereby achieved lies in the fact that, due to the provision of the drive
element as a constituent part of the drive module, and due to the ement of
le carpules next to one another, the drive means of the first drive module can
be arranged directly inside one of the hollow ers of the piston rods and/or
immediately next to them. Due to the possible arrangement of the drive means inside
said piston rods, it is possible to achieve a shorter, more compact structure of the
injection device.
If the first drive means is received next to the piston rods in its own accommodation
part, then likewise a reduction in the structural length can also be achieved even with
the arrangement of multiple carpules. By the formation of an individual drive element,
at which the piston rods are ed, as well as, if appropriate, also an individual
accommodation part laterally next to the piston rods, it is possible for a compact first
drive module configuration to be achieved. In addition to this, however, it is also
possible to provide a self-contained structural unit, e which none of the first
drive means are arranged. This allows for the arily sterilisation to be carried
out more simply and more securely.
Advantageously an individual cannula can be arranged in front of each of the at least
two carpules. This allows for recourse to be made to standard components.
Additionally, r, this also make it possible for ent cannula lengths to be
selected for the medications being administered, whereby it is possible to control the
penetration depth, and therefore the administration on, beneath the surface of
the skin.
Another embodiment is terised in that the drive t comprises a
connection part that connects the piston rods and the accommodation part to one
another at the end regions thereof that face towards the proximal end section, and
wherein the piston rods and the odation part t in the distal direction
from the connection part. Due to the provision of the additional connection part, it is
possible for a compact structural unit to be formed. In addition to this, however, the
opposing arrangement of the carpules in relation to one another is fied, in
particular if different carpule sizes are arranged next to one another.
A further possible embodiment has the features that the piston rods and the
accommodation part are in each case configured in the form of hollow cylinders and
are in each case configured as closed at the end regions f that face towards
the distal end section. In this way material can be saved and, moreover, a completely
closed outer surface can be formed, starting from the proximal end towards the distal
ageously, if only one of the pistons of a first carpule of the at least two
carpules is connected to the piston rod allocated to the piston, and the other of the at
least two carpules is held at the first e by means of a holding device. Due to
the coupling of the piston rod to the piston, the two carpules can in this way be held
at the drive element in a flexible manner in the event of loading being incurred due to
a fall load event. In the storage setting, the drive element is also held in position
relative to the carrying housing, as a result of which a specific location positioning of
the carpules is possible.
Another possible and, if appropriate, alternative embodiment requires that each of
the pistons is d to the piston rod allocated to it in each case, and the at least
two carpules are held independently of one another at the drive element. This allows
for each of the carpules to be held independently of one another at the common drive
element at the piston rods arranged there. This allows for greater individual flexibility
to be achieved with the holding of the carpules inside the carrying housing.
In a further embodiment the carrying housing comprises a front carrying housing part
with a front accommodation space, and a rear carrying housing part with a rear
accommodation space, and the two carrying housing parts can be connected to one
another in a connection n in the axial direction, in two different longitudinal
positions, in a first connection setting and in a second connection setting.
Subdividing the carrying housing into the two carrying g parts allows access
into the interior, which is for the most part enclosed, so that sterilisation can be
carried out, and, ing the sterilisation, for the previously sterilised interior to be
closed off entirely in relation to the outside surrounding environment. This allows all
the components ed inside the carrying housing to be kept sterile until the
injection device is used.
r preferably the two carrying housing parts can be connected to one another in
the connection section by means of a coupling device. This allows for an additional
guidance to be ed between the housing parts which are to be coupled. In
on, however, this also provides a more reliable location positioning of the two
carrying gs in relation to one another in at least one of the two connection
settings, and in particular in both connection settings.
Additionally or alternatively the rear carrying housing part comprises at least two
guide extensions that project in the distal direction, said guide extensions being
supported on the front carrying g part and lying on it. Providing the additional
guide extensions facilitates a better ment movement, free of g, between the
two connection settings of the two carrying housing parts. In addition, however, it is
also possible, in the first connection g, for an access to be formed between the
guide extensions into the accommodation space of the carrying housing.
Advantageously, in the first tion setting, the carrying housing parts exhibit a
longitudinal extension which is greater than in the second tion setting.
ingly, a perceptible relative location positioning to one another can be
achieved between the two carrying housing parts. It is also thereby possible,
however, for a gap to be formed between the two carrying housing parts in the larger
longitudinal extension, so as to allow for the sterilisation of the accommodation space
to be carried out.
Another ative embodiment is terised in that the front carrying housing
part exhibits a longitudinal extension in the axial direction, which is selected in a
value range with a lower limit of 60% and an upper limit of 95%, in particular with a
lower limit of 70% and an upper limit of 85%, related to the total longitudinal
extension of the two carrying housing parts in the second connection setting.
Accordingly, the accommodation space serving for the sterilisation, inside the
carrying g, can be substantially extended in the direction towards the rear
carrying g part. In addition, however, due to the fact that a sealing element is
provided in the connection region between the two carrying housing parts, the
sealing of the accommodation space can be relocated onto the drive element. Since
in the storage setting of the device the common drive element is held in position on
the carrying housing, in particular on the rear carrying housing part, it is also
possible, to avoid any relative changes of position between the sealing element and
the common drive element occurring in the event of vibrating, and therefore avoid
any contaminants, in ular germs, entering into the sterilised accommodation
space.
A further possible and, if appropriate, alternative embodiment has the features that
the distal end of the carrying housing, in particular the distal end of the front carrying
g part, comprises a number of openings that is equal to the number of
cannulas, wherein said openings allow for the passage of the distal ends of the
cannulas of the needle ement, and, in each case, are provided with a
puncturable sealing plug, in a g position therein. This allows for an individual
sealable passage region to be formed for each of the cannulas, which additionally
allows for the accommodation space to be tely sealed.
A further embodiment makes provision for a sealing element to be provided, said
sealing element being arranged between the front carrying housing part and the rear
carrying g part, and formed such as to run continuously over the
circumference. The sealing t prevents an ingress of contaminants, in
particular germs, into the sterilised accommodation space after the sterilisation the
accommodation space.
Further preferably the sealing element comprises a sealing attachment at the distal
end section that faces towards the front carrying housing part and runs over the
entire circumference, wherein the first connection setting of the two carrying housing
parts said sealing attachment is arranged at a distance from a face e of the
front carrying housing part; and, in the second connection g of the two carrying
housing parts, the sealing attachment is in sealing t on the face e of the
front carrying housing part. Due to the provision of the sealing attachment, it is
possible to create a simple sealing effect on the preferably flat-configured face
surfaces between the two ng housing parts.
A further preferred embodiment is characterised in that the sealing attachment of the
g element is supported on a face surface of the rear carrying g part,
facing towards the front carrying housing part, and, further, that the sealing t
extends into contact with the rear carrying housing part. This allows for a secure
support of the g element to be achieved for the relative nt procedure
between the two carrying housing parts. This also allows, however, in the second
tion setting of the two carrying housing parts, for a secure location fixing of the
sealing element to be achieved.
It can further be of advantage if the sealing element, in the storage setting of the
device and with the carrying housing parts being in the second connection setting, is
in full ferential sealing contact with both the rear carrying housing part and the
drive element arranged inside the housing part, in particular with the tion part
of the element. This allows for an all-round continuous seal seat to be created in the
region of the rear ng housing part, between the drive element and the carrying
housing, in particular the rear carrying housing part.
Another embodiment is characterised in that the carrying housing, in particular the
rear carrying housing part, comprises at its distal end a transverse wall with a latch
ment cut-out opening arranged in it. Accordingly, a secure engagement
position can be provided for the securing device, of which a part is arranged on the
common drive element, as well as a relative positioning in relation to each other.
A further possible embodiment has the features that the securing device ses
at least one retention hook, said at least one ion hook being arranged on the
drive element, in particular the connection part f, and wherein in the storage
setting of the device, the at least one retention hook is held in the latch engagement
cut-out opening in the transverse wall. This avoids the need for additional retention
elements, and therefore for a compact configured drive t to be provided,
which is arranged in the immediate proximity of the proximal end of the carrying
housing in the storage setting of the device.
A r embodiment makes provision for the securing device to comprise a
securing cap with a securing pin, arranged in the distal end section, and wherein by
means of the securing pin, the at least one retention hook is held in an engaged
position, in the storage setting of the device. Providing the securing cap with the
ng pin, prevents any unintentional triggering of the device.
A further embodiment is characterised in that the proximal end region of the
activation sleeve comprises a closure wall, and wherein said wall comprises a
triggering means, in particular a triggering opening, aligned flush in relation to the
engagement cut-out opening arranged in the transverse wall of the carrying housing,
in particular of the rear carrying g part. Due to the provision of the ring
means, it is possible, on actuation of the activation sleeve, for the automated release
procedure to be initiated, once the securing device has been released.
A further preferred embodiment is characterised in that the second drive means of
the second drive module is arranged outside the carrying housing, in ular
e the two carrying housing parts, but inside the activation sleeve. Accordingly,
a protected arrangement of the second drive means can be achieved. In addition this
arrangement prevents tampering in a reliable manner.
Advantageously the second drive means of the second drive module extends in the
axial direction between the needle tion element and the proximal end of the
carrying housing, in ular of the rear carrying housing part. Due to the relatively
long axial extension of the second drive means, it is le in this way to achieve a
slim configuration for this.
Advantageously the first drive means and/or the second drive means are tively
formed by a pressure spring, configured as a helical spring. This allows for recourse
to be made to conventional commercial and economically priced components. This
also allows for the movement force generated by the respective springs to be
adjusted individually in a simple manner to meet the tive conditions of use.
Another alternative embodiment is characterised in that the second drive means is
arranged on the side of the piston rods which, when viewed in cross-section, is
opposite the accommodation part of the drive element. It is therefore likewise
possible for a lly offset arrangement of the second drive means to be created
inside the injection device. This is additionally favoured in that the carrying housing is
matched in its cross-section shape to the cylindrically configured carpules, and in this
way a certain longitudinal guidance is already achieved on the outside of the ng
housing.
A further possible and, if appropriate, alternative embodiment requires that the
longitudinal extension of the second drive means is guided at least in sections by
means of guide ts, wherein the guide elements are arranged on an outer side
of the carrying housing, in particular of the front carrying housing part. This allows for
a folding outwards nt of the second drive means to be avoided, and for a
tilting of these drive means between the carrying g and the activation sleeve.
A further embodiment makes provision for the needle protection element to be held
locked in its cover position in on to the carrying housing in the al direction
as well as in the axial direction. This makes it possible to prevent a piercing injury
caused by the already used cannula ends of the cannulas, and ore prevents
the transfer of infections.
r embodiment is characterised in that the simultaneous release takes place of
both the first drive module as well as of the second drive module with the axial
movement of the activation sleeve relative to the carrying housing. This therefore
ensures both the administration of the medication as well as the subsequent
protective positioning of the needle tion element occur automatically without
contributory action by the .
For a better understanding of the invention, this is explained in greater detail on the
basis of the following figures.
The figures show, in each case in a greatly simplified schematic representation:
Fig. 1 The injection device in an illustrative representation, in its secured
storage setting;
Fig. 2 the injection device ing to Fig. 1, in an illustrative representation
but with the activation sleeve removed;
Fig. 3 the injection device according to Figs. 1 and 2, in a separated
arrangement of the component parts;
Fig. 4 the injection device according to Fig. 2, in an illustrative
representation, in a view onto the second drive module for the needle
protection element;
Fig. 5 the ion device according to Fig. 1, in its secured storage setting,
in an axial section through the carpules;
Fig. 6 the injection device according to Fig. 5, after administration and with
the needle protection element in the protective position;
Fig. 7 the injection device according to Fig. 5, in a section according to
the lines VII-VII in Fig. 5;
Fig. 8 the proximal end section of the injection device, in the sterilisation
position in the axial section h the securing device.
By way of uction, it may be pointed out that in the different embodiments
described the same parts are provided with the same reference numbers or the same
component ations, wherein the disclosures contained in the ption as a
whole can be transferred analogously to same parts with same reference numbers or
same component designations. The location s selected in the description, such
as upper, lower, lateral, etc. also relate to the figure being directly described and
represented, and, in the event of a change of location, these location details are to be
transferred analogously to the new location.
The term “in ular” is understood to mean hereinafter that this may relate to a
possible more special configuration or more detailed specific description of an object
or a method step, but does not arily ent a mandatorily preferred
embodiment or a mandatory form of procedure.
Figures 1 to 8 show different views and sections of an injection device 1, which can
also be designated as an autoinjector. Such autoinjectors serve to administer at least
one medication to a person 2 or a living creature, n the administration takes
place automatically and therefore without contributory action by the operator. Such
injection devices 1 are secured, in their storage setting, against unintentional
triggering, wherein the triggering or actuation can only take place by deliberate
release or disengagement of a securing device 14, described hereinafter. If release
has been ed, triggering or actuation can follow, as a result of which the injection
device 1 is automatically moved into an injection position, and, in this position, the
medication or medications stored in the device are administered.
In some application situations it may be necessary for several medications to be held
separately from one r in the injection device 1, without them coming in contact
with one another before the stration. It is for such a e that the injection
device 1 described hereinafter is provided. It is intended that at least two medications
should be held ready so that the medicaments can then be stered to the
patient 2 simultaneously in one administration procedure.
The injection device 1 comprises a distal end section 3, which in use is directed
towards the patient 2, and a proximal end section 4, which faces away from the
patient.
Described hereafter are individual modules or components of the injection device 1,
which the device can comprise. In addition, for the location indication, the
designations front and rear are used, and in this context ‘front’ is assigned to the
patient facing or distal end section 3 and ‘rear’ to the proximal end section 4.
The injection device 1 therefore comprises a carrying housing 5, which is ured
in the form of a sleeve and comprises a distal end 6 and a proximal end 7. Also
provided is an activation sleeve 8, which nds the carrying housing 5 over a
predominant part of its longitudinal extension, starting from the proximal end 7 in the
ion towards the distal end 6. In this arrangement, the distal end 6 of the carrying
housing 5 projects beyond the activation sleeve 8 in the distal direction. The
activation sleeve 8 is movable relative to the carrying housing 5 in the axial direction,
and guided on it. As will be described hereinafter, this relative movement serves for
the release and ore the associated administration of the medication or the
medications.
In the present exemplary embodiment, two es 9, 11 are arranged in the
carrying housing 5, accommodating the tions which are to be administered in
each case but are not designated in greater detail. In a known manner, arranged
inside each of the es 9, 11 is a piston 10, 12, for providing a sealing closure of
the carpules 9, 11 in their proximal end regions. For the administration of the
medications, the carpules 9, 11 are in drive connection with a first drive module 13.
The at least two carpules 9, 11, seen in section, are arranged next to one
another in the carrying housing 5. The activation or triggering of the drive module 13
can take place by means of the activation sleeve 8, after release of the securing
device 14.
The securing device 14 holds at least the first drive module 13 securely in its position
in relation to the carrying housing 5 until its activation for the injection procedure.
It can also be of advantage if, for each of the carpules 9, 11, in each case an
individual cannula 15, 16 is provided. The cannulas 15, 16 form a needle
arrangement 17. In the storage setting of the injection device 1, the needle
arrangement, and in particular its cannulas 15, 16, are ed in front of the
respective carpules 9, 11, in the section of the distal end 7. Each of the cannulas 15,
16 comprises in turn a ends 18, 19, wherein, in the storage setting, both of the
cannula ends 18, 19 respectively are also arranged inside the carrying housing 5. In
the storage setting, likewise, the proximal ends 19 of the cannulas 15, 16, are
arranged in front of the tive carpules 9, 11. The puncture, and ore the
access to the medication, does not take place until the activation of the ion
device 1 by the activation sleeve 8.
In order to cover the distal ends 18 of the cannulas, which t beyond the
carrying housing 5 after the stration of the medications, provision can also be
made for a needle protection element 20. If the injection device 1 is in the storage
setting, the needle protection element 20 is arranged in what is referred to as a
e position for the distal ends 18, in which unhindered movement of the
cannulas 15, 16 and the subsequent administration can take place. If the
administration procedure has begun, and the distal cannula ends 18 are still in the
inserted injection position in the patient 2, the needle protection element 20 can be
located in a position on the skin or on an item of clothing if the t 2 is a person.
For the automated adjustment movement of the needle protection element 20, a
second rable or activatable drive module 18 can be provided, which is in drive
connection with the needle protection element 20. This therefore makes it possible
for the needle protection element 20 to move beyond the distal cannula ends 18 after
the injection procedure, projecting from the ng housing 5 over the distal end 7,
into a cover position protecting these ends.
The drive module 13 can r comprise a drive t 22, which is likewise
arranged inside the carrying housing 5. The drive element 22 comprises in each case
a number of piston rods 23, 24 which is equal to the number of carpules 9, 11. The
piston rods 23, 24 form a composite structural unit.
It is also possible for at least one of the piston rods 23, 24 to be configured in the
form of a hollow er, and is formed as closed at an end region 25 that faces
towards the distal end section 3. In this case, it would be possible, depending on the
clear internal ion of the piston rod 23, 24, for a first drive means 46 of the first
drive module 13 to be arranged or accommodated in the at least one piston rod 23,
24 configured in the form of a hollow cylinder.
In on to or independently of this, however, it would also be possible to provide
an individual accommodation part 27 on the drive element 22, which, when seen in
cross-section, is arranged laterally next to the piston rods 23, 24. The first drive
means 26 to be arranged or accommodated inside this. It would also be possible,
however, for a multiple arrangement of first drive means 26 to be provided, with
which in each case a first drive means 26 is located both inside at least one of the
piston rods 23, 24 as well as inside the accommodation part 27.
If the accommodation part 27 is provided, this forms a composite structural unit with
the piston rods 23, 24. The drive element 22 can further comprise a connection part
28, by means of which the at least two piston rods 23, 24, and, if provided, also the
odation part 27, are connected to one another to form a structural unit. Each
of the piston rods 23, 24, and, if provided, also the accommodation part 27, exhibit
tive end regions 29, wherein the mutual connection to form a structural unit
takes place in the area of said end regions 29. Starting from the common connection
part 28, the at least two piston rods 23, 24 and, as appropriate, the accommodation
part 27 project from this in the distal direction (i.e. towards the ‘front’ of the device).
In order to save al and weight, it may be advantageous if the at least two
piston rods 23, 24 and the accommodation part 27 of the drive element 22 are
respectively configured in the form of hollow cylinders, and in each case are formed
as closed in at first end regions 25 thereof which face s the distal end section
There are various ent ilities for holding the carpules 9, 11, on the drive
element 22. The first possibility makes provision for only one of the pistons 10, 12 of
a first of the at least two carpules 9, 11 to be coupled to the piston rod 23, 24
allocated to the piston 10, 12, and therefore to be brought into drive connection. The
other of the at least two carpules 11, 9 is held by means of a holding device 30 at the
first of the at least two es 9, 11. The other piston rod 24, 23, which is not
coupled, serves only to drive forward the carpule 11 and the piston 12 arranged
within it.
In an alternative arrangement, provision is made for each of the pistons 10, 12 to be
coupled to the piston rods 23, 24 allocated respectively to the pistons, and the at
least two es 9, 11 are held on the drive element 22 independently of one
another.
In order to facilitate the assembly and the sterilisation of components arranged inside
the carrying housing 5, the carrying g 5 is subdivided into a first carrying
housing part 31 and a rear carrying housing part 32. The front carrying g part
31 delimits a front accommodation space 33 and the rear carrying housing part 32
ts a rear accommodation space 34. To provide mutual connection, the two
ng housing parts 31, 32 are connected to one another in a connection section
in the axial direction, in two different udinal positions, in a first connection
setting and a second connection setting. This can be done by means of a coupling
device 36, not represented in any greater detail. Accordingly, the carrying housing
parts 31, 32 in the first connection setting exhibit a greater longitudinal extension in
relation to the second connection setting.
In the present exemplary embodiment, the front ng house part 31 exhibits a
longitudinal extension in the axial direction, which is selected in a value range with a
value with a lower limit of 60% and a value with an upper limit of 95% related to the
overall longitudinal extension of the two carrying housing parts 31, 32, in their second
connection setting. It has, however, also transpired that a value range is favourable
with which a value is selected with a lower limit of 70% and a value with an upper
limit of 85% related to the overall longitudinal extension of the two ng housing
parts 31, 32, in their second connection setting.
It is further ented that the rear carrying housing part 32 can comprise at least
two guide extensions 37 projecting in the distal direction. It would also be le,
r, for the guide extensions 37 to be provided either only on the front carrying
housing part 31 or also on reciprocal sides. The guide extensions 37 are supported
at the front carrying g part 31 and/or at the rear carrying housing part 32, lying
in contact with them.
In order to avoid an undesirable ingress of dirt contamination to the cannulas 15, 16
and to the carpules 9, 11 during the storage setting of the device, provision is r
made for the distal end 7 of the carrying housing 5, in particular the distal end 7 of
the front carrying housing part 31, to exhibit a number of gs 38, equal to the
number of cannulas 15, 16. Since preferably the number of cannulas 15, 16 is
selected as equal to the number of es 9, 11, this number also corresponds to
the number of openings 38. Arranged in each case in the individual openings 38 is a
puncturable sealing plug 39, in a sealing position, wherein, by the openings 38, the
through passage of the distal cannula ends 18 of the cannulas 15, 16 is made
possible. During the administration procedure, the sealing plugs 39 are also
punctured by the cannulas 15, 16.
In order to provide mutual sealing between the two mutually facing ends of the two
carrying housing parts 31, 32, a sealing element 40 is also provided, which is formed
such as to run continuously over the circumference. The sealing element 40
comprises at its distal end section, facing towards the front carrying housing part 31,
a sealing attachment 41, running continuously over the entire circumference. The
preferably -shaped sealing attachment 41 can further be ured such that it
projects between mutually facing face surfaces 42, 43 of the two ng housing
parts 31, 32; see Fig. 8. In the first connection setting, described hereinbefore, a
ferential gap is also formed between the mutually facing face surfaces of the
two carrying g parts 31, 32, into which gap the sealing attachment 41 can also
project. In order to provide at least one access for carrying out the sterilisation by
means of a gasification process into the front accommodation space 33 of the front
carrying housing part 31, the gap width is to be selected as sufficiently large for the
gap not to be completely closed by the sealing attachment 41 located in it.
With this exemplary embodiment, provision is made for the sealing attachment 41, in
the first connection setting of the two carrying housing parts 31, to be arranged at a
distance from the face surface 42 of the front carrying g part 31. In the second
connection setting of the two carrying housing parts 31, 32, the sealing ment
41 is in g contact on the face surface 42 of the front carrying housing part 31.
The sealing attachment 41 of the sealing element 40 can also be supported on the
face surface 43 of the rear carrying g part 32, facing the front carrying housing
part 31. The circumferential sealing t 40 can also extend into the rear carrying
housing part 32, and be supported lying in t on its inner surface.
It is also important that the sealing t 40, in the storage setting of the device,
and with the carrying housing parts 31, 32 being in the second connection setting, is
also in sealing contact over the full circumference on the drive element 22, arranged
in the interior of the housing parts. A circumferential support of the sealing element
40 is preferably also to be provided on the inner e of the rear carrying housing
part 32. In any event, at least the front accommodation space 33, in the storage
setting of the device, is to be completely sealed against the outside surrounding
environment by means of the sealing element 40. The sealing contact of the sealing
t 40 is to be applied in particular at the outer circumference of the connection
part 28 of the drive t.
The securing device 14 comprises at least one retention hook 44, and preferably a
plurality thereof, which is or are arranged with at least one retention hook 44 on the
drive element 22. The connection part 28 of the drive element 22 comprises in this
context a face wall, aligned preferably in the perpendicular direction in relation to a
longitudinal axis 45 of the injection device 1, from which wall the at least one
retention hook 44 is arranged ting in the proximal direction. For the latch
engagement of the at least one retention hook 44, the carrying housing 5, in
particular the rear carrying housing part 32, can se at its distal end a
transverse wall 46, with a latch engagement cut-out opening 47 arranged in it.
Accordingly, the at least one retention hook 44, in the secure setting as well as in the
storage setting, can be held in the latch engagement cut-out opening 47 of the
transverse wall 46. In this setting, the at least one retention hook 44 engages behind
the erse wall 46, on its side facing the proximal end section 4. The first drive
means 26 is supported on the one hand at the rear carrying housing part 32, and in
the accommodation part 27, imposing preliminary tension on it. If the securing device
14 is released, the drive element 22 is displaced in the direction towards the distal
end 6 or the distal end section 3.
The securing device 14 can further comprise a securing cap 48, with a securing pin
49, ed in the al end section 4 of the injection device 1. By means of this
securing pin 49, the at least one retention hook 44, in the storage setting, is held in a
latched setting at the carrying housing 5. In order to release or free the at least one
retention hook 44, it is first to be freed by the securing pin 49.
The triggering, and, associated with this, the freeing of the at least one retention hook
44, is carried out by means of the activation sleeve 8. For this purpose, the sleeve
comprises in its proximal end region a e wall 50. Provided at the closure wall
50 is a triggering means 51, which, in this exemplary embodiment, is configured as a
trigger opening. The triggering means 51 is aligned in the axial direction flush in
relation to the latch engagement t opening 47 arranged in the transverse wall
46 of the carrying housing 5, in ular of the rear carrying housing part 32.
The needle protection element 20 is in drive connection with the second drive module
21; see Fig. 4. The second drive module 21 comprises at least one second drive
means 52, which is arranged outside the carrying housing 5, in particular the two
carrying housing parts 31, 32, and inside the activation sleeve 8. The second drive
means 52 s in the axial direction between the needle protection element 20
and the proximal end of the carrying housing 5, in particular the rear carrying housing
part 32. So, for example, the face wall of the connection part 28 can form a stop for
the second drive means 52.
It is advantageous if the first drive means 26 and the second drive means 52 are in
each case formed by a pressure spring configured as a helical . This allows for
recourse to be made to standard components. It therefore becomes possible to
select a slim configuration of the second drive means 52. ingly, the second
drive means 52, configured as a l spring, can be arranged on the side of the
piston rods 23, in cross-section located opposite the accommodation part 27 of the
drive element 22, between the carrying housing 5 and the activation sleeve 8.
In order to avoid the g outwards movement of the second drive means 52,
configured as a helical spring, the drive means can be guided in its longitudinal
extension at least in part by means of guide elements 53. The guide elements 53 can
be arranged on an outer side of the carrying housing 5, in particular of the front
carrying housing part 31, and can be formed by webs or ribs.
In order to prevent a ng injury caused by the already used cannulas 15, 16, the
needle protection element 20 can be held locked in its cover setting in the proximal
direction as well as in the axial direction relative in on to the carrying g 5
by means of a locking device, not represented in r .
The axial adjustment movement carried out by the activation sleeve 8 in on to
the carrying housing 5 has the effect of the simultaneous release of both the first
drive module 12 as well as of the second drive module 21.
In conclusion, it may also be pointed out that the configuration of the injection device
1 described hereinbefore, in particular of the autoinjector, in a number of component
groups, corresponds to that configuration such as in
forerunner company of the present Applicants. Accordingly, for the configuration of
the needle arrangement 17, and for the guiding and locking engagement of the
needle protection element 20 and of the carpules 9, 11, reference is made to the
disclosure contained in the WO-A1.
The exemplary embodiments show possible configuration variants, wherein it may be
noted at this juncture that the invention is not restricted to the configuration variants
which are specially represented, but rather that e combinations of the individual
embodiment variants among one another are possible, and that this variation
possibility, on the basis of the ng with regard to technical action by way of the
present invention, lies within the ability of the person skilled in the art engaged in this
The range of protection is determined by the claims. The description and the
drawings, however, are to be drawn on for the interpretation of the claims. dual
features or feature combinations from the different exemplary embodiments shown
and described can represent independent inventive solutions. The object underlying
the independent inventive solutions can be derived from the description.
All details relating to value ranges in the present description are to be understood
such that they encompass any and all part ranges; for e, the indication 1 to 10
is to be understood such that all part ranges, from the lower limit 1 to the upper limit
10, are encompassed, i.e. all part ranges ing with a lower limit of 1 or greater
and ending at an upper limit of 10 or less, e.g. 1 to 1.7, or 3.2 to 8.1, or 5.5 to 10.
For the sake of good order, it may be mentioned in conclusion that for better
tanding of the structure, elements have in part been represented not to scale,
and/or enlarged or reduced in size.
Reference number list
1 Injection device 31 Front carrying housing part
2 Patient 32 Rear carrying housing part
3 Distal end section 33 Front accommodation space
4 Proximal end n 34 Rear accommodation space
Carrying housing 35 Connection n
6 Distal end 36 Coupling device
7 al end 37 Guide extension
8 Activation sleeve 38 Opening
9 Carpule 39 Sealing plug
Piston 40 Sealing element
11 Carpule 41 Sealing ment
12 Piston 42 Face surface
13 First drive module 43 Face surface
14 Securing device 44 Retention hook
Cannula 45 Longitudinal axis
16 Cannula 46 Transverse wall
17 Needle arrangement 47 Latch engagement cut-out
18 First cannula end 48 Securing cap
19 Second cannula end 49 Securing pin
Needle protection element 50 Closure wall
21 Second drive module 51 Triggering means
22 Drive element 52 Second drive means
23 Piston rod 53 Guide element
24 Piston rod
First end region
26 First drive means
27 Accommodation part
28 Connection part
29 Second end region
Retaining device
Claims (15)
1.
2. An autoinjector, which is configured for the simultaneous administration of at least two medications, and can be automatically moved from a storage setting into an 5 injection position, and wherein the jector, which has a distal end section that, in use, is directed towards a patient and a proximal end section that faces away therefrom, comprises: a carrying housing configured in the form of a , and comprising a distal end and a proximal end; 10 an activation sleeve surrounding a predominant part of a longitudinal extension of the carrying housing, wherein the activation sleeve is moveable in relation to the carrying housing in an axial direction; first and second carpules arranged next to each other in the carrying housing, each of the first and second carpules having a piston arranged therein that is 15 adjustable in the axial ion, and having a medication received therein for administration during an injection ure; a first drive module with a first drive means, the first drive module being in drive connection with the first and second carpules, and being activatable by the activation sleeve; 20 a securing device to secure the first drive module in position relative to the carrying housing until activation of the first drive module for the ion procedure; a needle arrangement ing first and second cannulas, wherein, when in the storage setting of the autoinjector, the needle arrangement is arranged in front of the first and second es in the distal end section, and both ends of the first and 25 second cannulas are arranged inside the carrying housing; wherein the first drive module further comprises a drive element arranged inside the carrying housing, the drive element including first and second piston rods and an accommodation part, wherein the first drive means is ed in the accommodation part of the 30 drive t, such that, when viewed in cross-section, the first drive means is arranged lly next to the first and second piston rods , and wherein the accommodation part forms a composite structural unit with the first and second piston rods. 35 2. The autoinjector according to claim 1, wherein each of the first and second cannula is arranged in front of its respective first or second carpules.
3. The autoinjector according to claim 1 or 2, wherein the drive element comprises a connection part, that connects the first and second piston rods and the accommodation part to one another at a second end region thereof that faces towards the proximal end sections, and wherein the first and second piston rods and 5 the accommodation part project from the connection part in the distal direction.
4. The autoinjector according to any one of the preceding claims, wherein the first and second piston rods and the accommodation part are in each case ured in the form of hollow cylinders, and in each case configured as closed at the end 10 region (25) thereof that faces towards the distal end section.
5. The autoinjector ing to any one of claims 1 to 4, wherein each of the pistons is d to the first or second piston rod allocated to it in each case, and the first and second carpules are held independently from one another on the drive 15 element.
6. The autoinjector according to any one of the preceding claims, wherein the distal end of the carrying g, in particular the distal end of a front carrying housing part, comprises a number of gs that is equal to the number of 20 cannulas, wherein the openings allow for the through passage of the distal ends of the cannulas, and in each case a puncturable sealing plug is arranged in the openings in a sealing position.
7. The autoinjector ing to any one of the preceding claims, wherein a 25 sealing t is oned between the front carrying housing part and a rear carrying housing part of the carrying housing, and is configured to extend continuously over the circumference.
8. The autoinjector according to any one of the ing claims, wherein the 30 securing device comprises either: (a) at least one retention hook, the at least one retention hook being arranged on the drive t, in particular a connection part thereof and wherein, in the storage setting of the device, the at least one retention hook is held in a latch engagement cut-out opening of a transverse wall of the carrying housing; and/or 35 (b) a securing cap with a securing pin, arranged in the distal end section, and wherein by means of the securing pin the at least one retention hook is held in a latch d setting when in the storage setting of the autoinjector.
9. The autoinjector according to any one of the preceding , wherein the first drive means is formed by a pressure spring, configured as a helical spring.
10. The autoinjector according to any one of the preceding claims, wherein a 5 needle protection element is positioned at the distal end of the ng house, wherein, when in the storage g of the autoinjector, the needle protection element is le from a release position into a cover position, in which ends of the first and second cannulas are covered, and wherein the cannula ends project beyond the distal end of the carrying housing after the injection procedure.
11. The autoinjector according to claim 10, wherein a second table drive module with a second drive means is arranged to move the needle protection element from a tive position into the cover position. 15
12. The autoinjector according to claim 10 or 11, wherein the second drive means is arranged on the side of the first and second piston rods which when viewed in section, is opposite the accommodation part of the drive element.
13. The autoinjector according to any one of claims 10 to 12, wherein a 20 longitudinal extension of the second drive means is guided at least in part by guide elements, wherein the guide elements are arranged on an outer side of the carrying housing, in particular of the front carrying housing part.
14. The autoinjector according to any one of claims 10 to 13, wherein the needle 25 protection element, in the cover position in relation to the carrying housing, is held locked in the proximal direction as well as in the axial direction.
15. The autoinjector according to any one of claims 10 to 14, wherein simultaneous release takes place of the first drive module and the second drive 30 module with the axial cement of the activation sleeve relative to the carrying housing. W0 78121
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62/413,557 | 2016-10-27 | ||
ATA50987/2016 | 2016-10-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ793836A true NZ793836A (en) | 2022-10-28 |
Family
ID=
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