NZ767752A - Targeted delivery of tertiary amine-containing drug substances - Google Patents
Targeted delivery of tertiary amine-containing drug substancesInfo
- Publication number
- NZ767752A NZ767752A NZ767752A NZ76775215A NZ767752A NZ 767752 A NZ767752 A NZ 767752A NZ 767752 A NZ767752 A NZ 767752A NZ 76775215 A NZ76775215 A NZ 76775215A NZ 767752 A NZ767752 A NZ 767752A
- Authority
- NZ
- New Zealand
- Prior art keywords
- tertiary amine
- containing drug
- targeted delivery
- drug substances
- cancer
- Prior art date
Links
- 150000003512 tertiary amines Chemical class 0.000 title abstract 2
- 229940088679 drug related substance Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 208000023275 Autoimmune disease Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Abstract
Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed. The ligand drug conjugate (LDC) composition of formula 1 is used in the treatment of cancer or an autoimmune disease in humans or non-human mammals.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462049206P | 2014-09-11 | 2014-09-11 | |
US201462087218P | 2014-12-03 | 2014-12-03 | |
US201462087755P | 2014-12-04 | 2014-12-04 | |
NZ730552A NZ730552A (en) | 2014-09-11 | 2015-09-10 | Targeted delivery of tertiary amine-containing drug substances |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ767752A true NZ767752A (en) | 2023-12-22 |
Family
ID=89473733
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ767751A NZ767751A (en) | 2014-09-11 | 2015-09-10 | Targeted delivery of tertiary amine-containing drug substances |
NZ767752A NZ767752A (en) | 2014-09-11 | 2015-09-10 | Targeted delivery of tertiary amine-containing drug substances |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ767751A NZ767751A (en) | 2014-09-11 | 2015-09-10 | Targeted delivery of tertiary amine-containing drug substances |
Country Status (1)
Country | Link |
---|---|
NZ (2) | NZ767751A (en) |
-
2015
- 2015-09-10 NZ NZ767751A patent/NZ767751A/en unknown
- 2015-09-10 NZ NZ767752A patent/NZ767752A/en unknown
Also Published As
Publication number | Publication date |
---|---|
NZ767751A (en) | 2023-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ERR | Error or correction |
Free format text: THE TITLE HAS BEEN CORRECTED TO TITLE: TARGETED DELIVERY OF TERTIARY AMINE-CONTAINING DRUG SUBSTANCES ; FILING DATE: 10 SEP 2020; STATUS: REJECTED; KIND CODE: A1 PUBLICATION DATE: 25 SEP 2020; TITLE: TARGETED DELIVERY OF TERTIARY AMINE-CONTAINING DRUG SUBSTANCES ; FILING DATE: 21 AUG 2023; STATUS: REJECTED; KIND CODE: TITLE: TARGETED DELIVERY OF TERTIARY AMINE-CONTAINING DRUG SUBSTANCES ; FILING DATE: 14 DEC 2023; STATUS: REJECTED; KIND CODE: TITLE: TARGETED DELIVERY OF TERTIARY AMINE-CONTAINING DRUG SUBSTANCES ; FILING DATE: 15 DEC 2023; STATUS: PROPOSED; KIND CODE: Effective date: 20231215 |