NZ765579B2 - Highly efficacious hemostatic adhesive polymer scaffold - Google Patents

Highly efficacious hemostatic adhesive polymer scaffold

Info

Publication number
NZ765579B2
NZ765579B2 NZ765579A NZ76557915A NZ765579B2 NZ 765579 B2 NZ765579 B2 NZ 765579B2 NZ 765579 A NZ765579 A NZ 765579A NZ 76557915 A NZ76557915 A NZ 76557915A NZ 765579 B2 NZ765579 B2 NZ 765579B2
Authority
NZ
New Zealand
Prior art keywords
chitosan
chanmel
kda
polymeric composition
sodium alginate
Prior art date
Application number
NZ765579A
Other versions
NZ765579A (en
Inventor
Omar M Ahmad
Joseph A Landolina
Original Assignee
Cresilon Inc
Filing date
Publication date
Application filed by Cresilon Inc filed Critical Cresilon Inc
Priority to NZ765579A priority Critical patent/NZ765579B2/en
Priority claimed from PCT/US2015/036894 external-priority patent/WO2016209198A1/en
Publication of NZ765579A publication Critical patent/NZ765579A/en
Publication of NZ765579B2 publication Critical patent/NZ765579B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/225—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0036—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/04—Alginic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

The invention relates to biocompatible polymer gel compositions useful in facilitating and maintaining hemostasis. The biocompatible polymeric gel composition is comprised of (a) one or more than one polyanionic polymer, (b) one or more than one polycationic polymer, and (c) a solvent. A preferred composition includes sodium alginate, chitosan, and water to produce an adhesive hemostatic device that is useful in facilitating and maintaining rapid hemostasis.

Claims (34)

What is claimed is:
1. A method of making a polymeric composition comprising:
a. mixing sodium alginate with water to make a first mixture, wherein in the first
mixture the sodium te is dissolved in the water; and
b. adding chitosan to said first mixture to provide the polymeric composition;
and wherein the polymeric composition is a colloidal gel dispersion with about 5% to
about 40% by weight of chitosan solid particles dispersed in a solution of about 1% to
about 5% by weight of sodium alginate in about 50% to about 94% by weight of water.
2. A method of claim 1 wherein said sodium alginate has a chain length of between
about 1,000 nm and about 3,000 nm.
3. A method of claim 1 or claim 2, wherein the sodium alginate has an e
molecular weight of about 100 kDa to about 1,000 kDa.
4. A method of claim 1 or claim 2, wherein the sodium alginate has an average
molecular weight of about 500 kDa to about 900 kDa.
5. A method of claim 1 or claim 2, wherein the sodium alginate has an average
molecular weight of about 800 kDa.
6. A method of any one of claims 1 to 5 wherein the chitosan has a chain length of
between about 2,000 nm and about 4,000 nm.
7. A method of any one of claims 1 to 5, wherein the chitosan has a chain length of
between about 2,800 nm and about 2,900 nm.
8. A method of any one of claims 1 to 5 n the chitosan has a chain length of
about 2850nm.
9. A method of any one of claims 1 to 5, wherein the an has an e molecular
weight of between about 1 kDa to about 2,000 kDa.
10. A method of any one of claims 1 to 5, wherein the chitosan has an average molecular
weight of between about 1 kDa to about 1,000 kDa.
11. A method of any one of claims 1 to 5, wherein the chitosan has an average molecular
1004795410
weight of about 1,000 kDa.
12. A method of any one of claims 1-11 where said an has an average degree of
deacetylation of between about 75.0% to about 99.5%.
13. A method of any one of claims 1 to 12, wherein the chitosan is derived from an
organic source.
14. A method of any one of claims 1 to 13, wherein the chitosan is derived from at least
one of marine invertebrates and fungi.
15. A method of any one of claims 1 to 14, wherein the sodium alginate is derived from
an organic source.
16. A method of any one of claims 1 to 15, wherein the sodium alginate is derived from
marine algae.
17. A method of any one of claims 1 to 16, wherein the polymeric composition has a
maximum clot strength from about 90 to about 200 clot strength units.
18. A method of any one of claims 1 to 16, wherein the polymeric composition
withstands a vertical strain of up to about 0.5 Newtons per square millimeter without
fracture.
19. A method of any one of claims 1 to 18, wherein the viscosity of the ric
composition is from about 145,000 cP to about 250,000 cP at about 25°C.
20. A method of any one of claims 1 to 18, n the viscosity of the polymeric
composition is about 169,500 cP at about 25°C.
21. A method of any one of claims 1 to 20, wherein the polymeric composition has a pH
of about 7.0.
22. A method of any one of claims 1 to 21, wherein the polymeric ition has a
Fourier Transform Infrared spectrum depicted in
23. A method of any one of claims 1 to 21, wherein the polymeric ition has a
Fourier Transform Infrared spectrum comprising absorption peaks at: from about
3,600 cm-1 to about 3,000 cm-1, about 2,900 cm-1, about 1,640 cm-1, and about
1,590 cm-1.
1004795410
24. A method of any one of claims 1 to 23, wherein the chitosan has an average degree
of deacetylation of n about 75.0% to about 85.0%.
25. A method of any one of claims 1 to 24, wherein the chitosan has an average degree
of deacetylation of between about 78.0% to about 83.0%.
26. A method of any one of claims 1 to 25, wherein the chitosan has an average degree
of ylation of between about 80.0% to about 81.0%.
27. A method of any one of claims 1 to 26, wherein the chitosan has an average degree
of deacetylation of about 80.5%.
28. A method of any one of claims 1 to 27, n the polymeric composition has a
density of between about 1.10 g/mL and about 1.30 g/mL at about 25°C.
29. A method of any one of claims 1 to 27, wherein the polymeric ition has a
density of about 1.21 g/mL at about 25°C.
31. A method of any one of claims 1 to 27, wherein the polymeric ition has a
s of elasticity of between about 6 kPa and about 23 kPa.
32. A method of any one of claims 1 to 31, wherein the polymeric composition has a
modulus of elasticity of about 16 kPa.
33. A method of claim 1, wherein the polymeric composition is a colloidal gel
dispersion with about 8% by weight of chitosan solid particles dispersed in a
solution of about 2.5% by weight of sodium alginate in about 89.5% by weight of
water.
34. A method of claim 1 or claim 33, wherein the polymeric composition has a viscosity
between about 165,000 cP and about 174,000 cP at about 25°C and the chitosan has an
average degree of deacetylation of between about 75.0% and about 99.5%.
1004795410
None set by chanmel
ionNone set by l
Unmarked set by chanmel
None set by chanmel
MigrationNone set by chanmel
Unmarked set by l
None set by chanmel
MigrationNone set by chanmel
Unmarked set by chanmel
None set by chanmel
MigrationNone set by chanmel
Unmarked set by chanmel
::::::::::::::::::::::::i....i....i....i....i....i....i....i....i....i....i....i....i....i....i....i....i....i....i....i....i....i....it.‘it.‘it.‘it.‘it.‘it.‘it.55555555::::::::::::.:.::::::::u. _
. mwmw
_ mmww W“
mmww EQEmmmwmg
. mmmm
‘ “8mm.
‘ ~yi~y.,x~yé.~y~m.~y#thtAth?‘tAt.a~y~m-~\,-~n~y~x.-~m-~A~y~s.-~m-~myy~n.-~A-~iy~+-i-iy~i-\\-~xy~yx-L<-+y-x-yx-~..y-w-ya-~x,y-a-yw.-~Ay-A-y«.-~My-a-~a--.-~x.x-a.-a.-~\-¢‘-?y~iy~xxy~xvy~iy~iy~yxtthttxtuxt?tx Q?m
u.
NZ765579A 2015-06-22 Highly efficacious hemostatic adhesive polymer scaffold NZ765579B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ765579A NZ765579B2 (en) 2015-06-22 Highly efficacious hemostatic adhesive polymer scaffold

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2015/036894 WO2016209198A1 (en) 2015-06-22 2015-06-22 Highly efficacious hemostatic adhesive polymer scaffold
NZ765579A NZ765579B2 (en) 2015-06-22 Highly efficacious hemostatic adhesive polymer scaffold
NZ739244A NZ739244A (en) 2015-06-22 2015-06-22 Highly efficacious hemostatic adhesive polymer scaffold

Publications (2)

Publication Number Publication Date
NZ765579A NZ765579A (en) 2023-12-22
NZ765579B2 true NZ765579B2 (en) 2024-03-26

Family

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