NZ764072A - Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan - Google Patents
Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphanInfo
- Publication number
- NZ764072A NZ764072A NZ764072A NZ76407215A NZ764072A NZ 764072 A NZ764072 A NZ 764072A NZ 764072 A NZ764072 A NZ 764072A NZ 76407215 A NZ76407215 A NZ 76407215A NZ 764072 A NZ764072 A NZ 764072A
- Authority
- NZ
- New Zealand
- Prior art keywords
- day
- dextromethorphan
- bupropion
- twice
- orally administered
- Prior art date
Links
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 title claims abstract 9
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 title claims abstract 9
- 229960001058 bupropion Drugs 0.000 title claims abstract 9
- 229960001985 dextromethorphan Drugs 0.000 title claims abstract 9
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000002459 sustained effect Effects 0.000 title 1
- 239000012458 free base Substances 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to the use of a combination of dextromethorphan and bupropion for treating depression, by oral administration of 40-100 mg of dextromethorphan and 90-150 mg of bupropion (each in free base or salt form) once or twice a day for at least 14 days. The claimed treatment regime results in a Cmin of 3-110 ng/mL on the seventh day of administration.
Claims (10)
1. Use of a ation of dextromethorphan and bupropion for the manufacture of a medicament for treating depression, wherein the treatment comprises orally administering the ation of about 40 mg to about 100 mg of dextromethorphan in the free base or a salt form and about 90 mg to about 150 mg of bupropion in the free base or a salt form, once a day or twice a day, for at least 14 days, to a human being suffering from depression, and wherein on the seventh day, the Cmin of dextromethorphan is about 3 ng/mL to about 110 ng/mL.
2. The use of claim 1, wherein about 0.6 mg/kg to about 1 mg/kg of the dextromethorphan is to be orally administered once a day or twice a day.
3. The use of claim 1 or 2, n about 0.6 mg/kg to about 0.8 mg/kg of the dextromethorphan is to be orally administered once a day or twice a day.
4. The use of claim 1, 2, or 3, wherein about 45 mg of the dextromethorphan is to be orally administered once a day or twice a day.
5. The use of claim 1, 2, 3, or 4, wherein about 100 mg to about 150 mg of the bupropion is to be orally administered once a day or twice a day.
6. The use of claim 1, 2, 3, or 4, wherein about 95 mg to about 150 mg of the ion is to be orally administered once a day or twice a day.
7. The use of claim 1, 2, 3, or 4, wherein a total amount of about 150 mg to about 250 mg of the bupropion is to be orally administered daily.
8. The use of claim 1, 2, 3, or 4, wherein a total amount of about 105 mg to about 200 mg of the bupropion is to be orally administered daily.
9. The use of claim 1, 2, 3, or 4, wherein about 105 mg to about 150 mg of the bupropion is to be orally administered once a day or twice a day.
10. The use of claim 1, 2, 3, or 4, wherein about 100 mg to about
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/550,618 US9198905B2 (en) | 2013-11-05 | 2014-11-21 | Compositions and methods for reducing dextrorphan plasma levels and related pharmacodynamic effects |
| US14/554,988 US9205083B2 (en) | 2013-11-05 | 2014-11-26 | Compositions and methods comprising erythrohydroxybupropion and related compounds for improving the efficacy of dextromethorphan |
| US14/554,947 US20150126542A1 (en) | 2013-11-05 | 2014-11-26 | Compositions and Methods for Increasing the Metabolic Lifetime of Dextromethorphan and Related Pharmacodynamic Effects |
| US14/555,085 US9238032B2 (en) | 2013-11-05 | 2014-11-26 | Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan |
| US14/602,177 US9402843B2 (en) | 2013-11-05 | 2015-01-21 | Compositions and methods of using threohydroxybupropion for therapeutic purposes |
| US14/604,397 US9168234B2 (en) | 2013-11-05 | 2015-01-23 | Bupropion as a modulator of drug activity |
| US14/617,624 US9486450B2 (en) | 2013-11-05 | 2015-02-09 | Hydroxybupropion and related compounds as modulators of drug plasma levels |
| US14/628,062 US9402844B2 (en) | 2013-11-05 | 2015-02-20 | Methods of modulating drug plasma levels using erythrohydroxybupropion |
| NZ747111A NZ747111A (en) | 2014-11-21 | 2015-05-01 | Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ764072A true NZ764072A (en) | 2022-12-23 |
Family
ID=84527790
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ764088A NZ764088A (en) | 2014-11-21 | 2015-05-01 | Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan |
| NZ764077A NZ764077A (en) | 2014-11-21 | 2015-05-01 | Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan |
| NZ764072A NZ764072A (en) | 2014-11-21 | 2015-05-01 | Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ764088A NZ764088A (en) | 2014-11-21 | 2015-05-01 | Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan |
| NZ764077A NZ764077A (en) | 2014-11-21 | 2015-05-01 | Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan |
Country Status (1)
| Country | Link |
|---|---|
| NZ (3) | NZ764088A (en) |
-
2015
- 2015-05-01 NZ NZ764088A patent/NZ764088A/en unknown
- 2015-05-01 NZ NZ764077A patent/NZ764077A/en unknown
- 2015-05-01 NZ NZ764072A patent/NZ764072A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ764077A (en) | 2022-12-23 |
| NZ764088A (en) | 2023-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAY 2024 BY ANAQUA SERVICES Effective date: 20230420 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAY 2025 BY ANAQUA SERVICES Effective date: 20240418 |