NZ755929B2 - HIV Inhibitor compounds - Google Patents
HIV Inhibitor compounds Download PDFInfo
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- NZ755929B2 NZ755929B2 NZ755929A NZ75592918A NZ755929B2 NZ 755929 B2 NZ755929 B2 NZ 755929B2 NZ 755929 A NZ755929 A NZ 755929A NZ 75592918 A NZ75592918 A NZ 75592918A NZ 755929 B2 NZ755929 B2 NZ 755929B2
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- 150000001875 compounds Chemical class 0.000 title abstract description 13
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 title description 2
- 239000003112 inhibitor Substances 0.000 title description 2
- 230000002401 inhibitory effect Effects 0.000 title description 2
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- 206010000565 Acquired immunodeficiency syndrome Diseases 0.000 abstract description 6
- WTKZEGDFNFYCGP-UHFFFAOYSA-N pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract description 6
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, the compound of formula (I) for use in therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I. Preferred compounds are N-[(2S) -1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino) -3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(phenyl) methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate atazanavir (ATV) analogues substituted by several heterocycles, such as e.g. pyrazole (Rl); e.g. oxetane (substituent of X2); e.g. pyridine or pyrimidine (X1); e.g. piperazine or 3,8-diazabicyclo[3.2.1]octan (X2). eutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I. Preferred compounds are N-[(2S) -1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino) -3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(phenyl) methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate atazanavir (ATV) analogues substituted by several heterocycles, such as e.g. pyrazole (Rl); e.g. oxetane (substituent of X2); e.g. pyridine or pyrimidine (X1); e.g. piperazine or 3,8-diazabicyclo[3.2.1]octan (X2).
Description
(12) d patent specificaon (19) NZ (11) 755929 (13) B2
(47) Publicaon date: 2021.12.24
(54) HIV Inhibitor compounds
(51) Internaonal Patent Classificaon(s):
C07D 403/12 C07D 405/14 C07C 275/16 C07D 401/12 C07D 471/08 C07D 487/08 C07D 487/10
C07D 491/04 C07C 243/28 A61K 31/495 A61K 31/504 A61K 31/506 A61K 31/5365A61K 31/4155
A61K 31/337 A61P 31/14 A61P 31/18
(22) Filing date: (73) Owner(s):
2018.02.05 GILEAD SCIENCES, INC.
(23) Complete specificaon filing date: (74) Contact:
2018.02.05 DAVIES COLLISON CAVE PTY LTD
(30) Internaonal Priority Data: (72) Inventor(s):
US 62/455,348 2017.02.06 BACON, Elizabeth, M.
COTTELL, Jeromy, J.
(86) Internaonal Applicaon No.: KATO, Darryl
LINK, John, O.
TREJO MARTIN, Teresa, Alejandra
(87) Internaonal Publicaon number: YANG, Zheng-Yu
WO/2018/145021 CHIN, Elbert
KATANA, Ashley Anne
SHAPIRO, Nathan
(57) Abstract:
The invenon provides a nd of Formula I: or a pharmaceucally acceptable salt thereof
as bed herein. The invenon also provides pharmaceucal composions comprising a
compound of Formula I, processes for preparing compounds of Formula I, the nd of
formula (I) for use in therapeuc methods for treang the proliferaon of the HIV virus, treang
AIDS or delaying the onset of AIDS symptoms in a mammal using nds of Formula I.
Preferred compounds are N-[(2S) [2-[(2S,3S)hydroxy[[(2S)(methoxycarbonylamino)
-3,3-dimethylbutanoyl]amino]phenylbutyl][(phenyl) methyl]hydrazinyl]-3,3-dimethyl
oxobutanyl]carbamate avir (ATV) analogues substuted by several heterocycles, such as
NZ 755929 B2 e.g. pyrazole (Rl); e.g. oxetane (substuent of X2); e.g. pyridine or dine (X1); e.g. zine
or 3,8-diazabicyclo[3.2.1]octan (X2).
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FGE6H ;IJ 2KL4MN ODPQR PM 2Q SDT FUKK DQJB D98V>7WX1YZ[\]\^_`a\bYc\d\e\f_f\ghc\`g[c\^_if\
F<B j k LM4 QJB 2QHB lM3m 1 lM4l F;B nQHB lM43 F<B j k mMU QJB 2QHB lMn2 F<B j k NMK QJB mQHB lMmn
F<B j k lML QJB mQHB lM2m F<B j k NM2 QJB mQHB lMKU F?B 2QHB 3M3l F<B j k LMl QJB 2QHB 3M43 F<B j k
2K NMN QJB 2QHB 3MUl F<B j k mMU QJB 2QHB UML3 F?B 2QHB UMNL 1 UMNn F;B 2QHB UMNU 1 UMlN F;B 2QHB UM34
1 UM4U F;B 2QHB UM4U 1 UMUU F;B mQHB UMU2 F?B 2QHB UMnK F<B j k LML QJB 2QHB UM23 F<B j k LMl QJB
2QHB UM2m 1 UMKK F;B 2QHB nMNN F<B j k 2nMm QJB 2QHB nMlN F<B j k 2nM4 QJB 2QHB nMln 1 nM3K F;B
mQHB nM3K 1 nM4n F;B UQHB nM42 F?B nQHB mMNl 1 mMl3 F;B mQHB mMl3 1 mM4L F;B mQHB mMmn F?B mQHB
2MKl 1 KMLU F;B 2KQHB KMLm F?B nQHB KMlm F?B nQHM
12321
56789 5
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$ ! "#$# $#. % - / / #. (, * 0
()(+ 1 1 #20303 4 ' (, 0 ' $ , * , + ,) * - * $ #.# $ ! "#$#
7 0 % '$#'(, 0 0 #.( 5 0 $(()( .( 1(, 1($+(%( 0 6
;>?@:;AB C0D E-D @9> -3 FG HIG8J =KL 22M76N OFPQR P6 2Q SFT HUMM FQLD F;:V@9WX1
YZ[\]\^_`a\bYc\d\e\`_`\fgc\hf[c\^_hh\bYc\d\e\i_j\fgc\hf[c\^_ka\bYc\d\e\`_l\fgc\hf[c\l_l^\bYc\d\e\^_h\
QLD 4QJD m63N H>>D n o p6pD 46q QLD 2QJD m6UN H:D n o 7N6m QLD 2QJD m6U7 H>D n o p62 QLD 4QJD m6q4
H>D n o m6N QLD 4QJD m644 H>D n o p62 QLD 4QJD m624 H>D n o N6U QLD 2QJD 36p3 H>D n o 46m QLD 2QJD
2M 36mm H>D n o N6N QLD 2QJD 3633 H>D n o p6m QLD 2QJD 76M7 HAD 2QJD U6N7 H>>D n o p6UD 367 QLD 2QJD
U6Nq 1 U6pm H=D 2QJD U6mM H>>D n o p67D U63 QLD 2QJD U633 1 U67q H=D 4QJD U67M HAD 2QJD U6UM H>D n o
N6N QLD 2QJD U64U H>D n o N6p QLD 2QJD U642 1 U624 H=D 2QJD U6M2 H>D n o 2q64 QLD 2QJD q6pp H>D n o
2q64 QLD 2QJD q6p4 1 q63N H=D 4QJD q63p HAD qQJD q67N HAD qQJD 46N3 1 4633 H=D UQJD 46qq HAD 4QJD
2624 HAD qQJD 262M HAD qQJD 26M4 HAD qQJD M6pq HAD qQJ6
56789 5 rs
% 1 1 #'$#' & ' $()# * + ,) - - - $ ! "#$#
$#. % 0 / / #. (, * 0 ()(+ 1 1 #20303 4 ' (, 0
4M ' $ % , , + ,) * - * $ #.# $ ! "#$# 0 % '$#'(, 0 0
#.( 5 0 $(()( .( 1(, 1($+(%( *t 6 89:;<=;>?@:;AB C0D E0 D @9> 0 3 FG
HIG8J =KL 2MN36m OFPQR P6 2Q SFT HUMM FQLD F;:V@9WX1YZ[\]\^_ah\buc\`f[c\^_hk\bYc\d\e\i_k\
QLD 2QJD m63p H>D n o p6M QLD 4QJD m637 H>D n o 46U QLD 2QJD m6UM H>D n o m6N QLD 4QJD m6qU H>D n o
m6p QLD 4QJD m644 H>D n o m6N QLD 4QJD 36m3 H>D n o 2M62 QLD 2QJD 3673 H>D n o 46U QLD 2QJD 762p HAD
47 2QJD U6Nq H>:D n o 4M63D m6q QLD 2QJD U6m4 HAD 2QJD U637 1 U677 H=D 2QJD U672 HAD MQJD U6UM H>D n o
12341
567 89 28 6 567 89 28 62 28 6 1 4657 48 4635 48 4633
467 89 28 46 48 6 1 635 8 6 2 1 64 8 6 1 26 28 26 4
28 262 1 26 2 8 26 2 48 672 48 6
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242090B!"#$%34236@090$%/0902A60.*G*--*-90"!"46676#!A6;!16@0-.0$%/164?6B6"!&'8-/E
HIJKL K MNJK O P9 &Q-8 NI &)9,E&RS TSH U9 224 64 VRW8X W6 28 YRZ R89 RKJ[NI\]1
^_`abacdefaghiajk`iacdfeag^ialamand_akoiafk`iapdqnag^ialamajd_akoiafk`iapdrca1 56 5 8 56 4
76 89 8 562 2 6 89 28 3655 67 89 28 3634 6 89 28
2 627 28 6 4 J 6 564 89 8 65 28 63 J 2 62 226 6 89 28
6 2 28 6 3 1 64 28 643 1 6 28 627 1 6 5 8 46 4 226 89
28 467 28 467 2 65 89 28 4653 1 4635 8 4633 8 6 3 1 65
8 644 8 26 1 26 2 8 26 48 6
12341
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()(- 1 1 #2+3+3 4 ' (. + ' $ % . . - .) * , * $ #/#
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789:;<:=>?9:@A B+C D C ?8= + 3 EF GHF7I <JK 224LM4 NEOPQ OM 2P RES G4TT EPKC VW1
XYZ[\[]^_`[abc[deZc[]^`Y[aXc[f[g[h^i[ejc[`eZc[]^`k[aXc[f[g[d^l[ejc[`eZc[l^_d[amc[f[g[_h^h[ejc[`PIC
nM44 G=C o p qML PKC LPIC nMr4 G=C o p nMs PKC LPIC nMLr G=C o p qMT PKC LPIC nMTs G=C o p sM3 PKC
2T 2PIC 3Msr G=C o p LMn PKC 2PIC 3Mnq G=C o p sMs PKC 2PIC 5M2q G@C 2PIC 4Msr G=9C o p LTM5C nMr PKC
LPIC 4Mn2 G@C 2PIC 4M3T G=tC o p 22M3C 3MLC 5M3 PKC LPIC 4M52 G@C 2PIC 4M44 G=C o p sMq PKC 2PIC
4MrT G=C o p sMs PKC 2PIC 4ML2 1 4MT5 G<C LPIC rMs4 G=C o p 2rM5 PKC 2PIC rMsT G=C o p 2LMs PKC
2PIC rMqT G=C o p 2LM3 PKC 2PIC rMnn 1 rMnT G<C LPIC rM3q G@C rPIC rM33 G@C rPIC LMs3 1 LMnL G<C
4PIC LM44 1 LML4 G<C LPIC 2M23 G@C rPIC 2M24 G@C rPIC 2M22 G@C rPIC 2MTL G@C rPIM
12341
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DEC4F 9GH 22IJKI LBMNO MK 2N PBQ DIRR BNH@ B76S<5TU1VWXYZ [K4J D=@ JNF@ [K2R D:@ \ ] ^K4
NH@ 2NF@ _K3[ D:@ \ ] [K2 NH@ JNF@ _K3I D:@ \ ] JK` NH@ 2NF@ _KIR D:@ \ ] [KR NH@ JNF@ _K`I D:@ \ ]
_K^ NH@ JNF@ _KJJ D:@ \ ] [KR NH@ JNF@ _K22 D:@ \ ] ^K4 NH@ 2NF@ 3K_4 D:@ \ ] ^K_ NH@ 2NF@ 3K43 D:@
\ ] JKI NH@ 2NF@ IK^3 D6@ \ ] _K3 NH@ JNF@ IK[J 1 IK_2 D9@ `NF@ IK`^ D:@ \ ] ^K^ NH@ 2NF@ IKJI D:@ \
2R ] ^K_ NH@ 2NF@ IKJR 1 IKR3 D9@ JNF@ `K^_ D:@ \ ] 2`KJ NH@ 2NF@ `K[_ D:@ \ ] 2`KI NH@ 2NF@ `K__ 1
`K_2 D9@ 2NF@ `K3_ D=@ INF@ `K4^ D=@ `NF@ `KI4 D:@ \ ] 2IK3 NH@ JNF@ JK^` 1 JK[3 D9@ JNF@ JK[4 1
JK3_ D9@ 2NF@ JK`2 1 JK24 D9@ JNF@ JKR3 1 2K^` D9@ JNF@ 2K24 1 2KR` D9@ 2RNF@ 2KR2 D=@ `NF@ RK[J
D=@ `NFK
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22R^K4 LBMNO MK 2N PBQ DIRR BNH@ B76S<5TU1VWXYZYbcdeYfVgYhYiYdcjYklgYmkXgYbcejYfVgYhYiYncoY
NH@ 2NF@ _K33 1 _K4[ D9@ `NF@ _K43 D:@ \ ] JKI NH@ 2NF@ _K`2 D:@ \ ] [KR NH@ JNF@ _KJ` D:@ \ ] _K^
NH@ JNF@ _K2J D:@ \ ] [K2 NH@ JNF@ _KR_ D:@ \ ] ^K4 NH@ 2NF@ 3K_3 D:@ \ ] [K^ NH@ 2NF@ 3K3[ D:@ \ ]
2RKR NH@ 2NF@ 3KI_ D:@ \ ] JKI NH@ 2NF@ IK^J 1 IK[J D9@ JNF@ IK_I 1 IK33 D9@ JNF@ IK`I 1 IKJ2 D9@
J4 `NF@ IK2[ 1 IK2J D9@ 2NF@ IK22 1 `K^^ D9@ `NF@ `K[[ D:@ \ ] 2`K2 NH@ 2NF@ `K_[ D:@ \ ] 2`K` NH@
12341
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8 3 6 456 8 3 1 893 6 456 82 1 8 6 456 8 7 1 28 6 456 28 1 8 6
27456 8 6 7458
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2 GHIJK J LMIJ N 86 MH &)9E&QR SRG5 T 222 89 UQV4W V8 24 XQY Q4 6 QJIZMH[\1
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6 8 4 6 2456 8 2 1 8 3 6 456 8 2 6 8 4 6 456 827 6 8 4 6 2456 38 3
6 8 4 6 2456 38 6 8 4 6 2456 3837 6 8 4 6 2456 83 6 2 8 4 6 456
897 1 8 2 6 2456 879 1 8 9 6 2456 8 1 8 3 6 456 78 7 6 278 4 6 2456 78 I6
29 2 8 6 78 4 6 456 78 7 1 783 6 456 7833 6 7456 7837 6 456 782 6 7456 8 1 8
6 456 28 2 1 8 6 23458&
12331
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%!" #$%$ / '%$'(- $.( 5 %(()( .( 0(- 0(%,(/( *+ 2
9<=>89?@ A B C DB >7< 52 EF GHF6I ;JK 224LMN OEPQR PM 2Q SET GULL EQKB E98V>7WX1
YZ[\]\^_`a\bcd\ef[d\^_gh\bYd\i\j\h_a\fkd\gf[d\l_lZ\bYd\i\j\e_Z\fkd\gf[d\l_al\bYd\i\j\^_`\fkd\ef[d\
4MmU G<B n o pM2 QKB qQIB 4Mqm G<B n o pM2 QKB qQIB 4M24 G<B n o 2LML QKB 2QIB 3Mp2 G<B n o NMN QKB
2L 2QIB 3M4U G<B n o qMU QKB 2QIB 3Mqq G88B n o 44MmB UML QKB 2QIB 4MLq 1 UMNm G;B qQIB UMpm 1 UM4p G;B
qQIB UM44 G?B 2QIB UM3L G8<B n o 2UMmB mMN QKB qQIB UMUU G<B n o 2LML QKB 2QIB UMm2 G<B n o 2LML QKB
2QIB UMqq 1 UMLm G;B UQIB mMNm G<B n o 2mMq QKB 2QIB mM4q G?B qQIB mM3N G?B mQIB mM33 G?B mQIB mM42
1 mMUL G;B qQIB qMN3 1 qMp2 G;B mQIB qMp2 1 qM4q G;B 2QIB qMq4 1 qM2q G;B qQIB qMLU 1 2MNU G;B
qQIB 2M23 G?B mQIB 2M2U G?B mQIB 2M22 G?B mQIB 2MLm G?B mQIM
12341
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9<=>89?@ A'B C &B >7< 52 DE FGE6H ;IJ 22K3LM NDOPQ OL 2P RDS FKTT DPJB D98U>7VW1
XYZ[\[]^Y_[`ab[cdZb[]^ef[`Xb[g[h[i^_[djb[edZb[k^lf F<B m n oLK PJB 2PHB pLo4 F<B m n 4LT PJB KPHB
pL2K F<B m n 4L2 PJB oPHB pLTp F<B m n 2TL2 PJB 2PHB 3Lpo F<B m n 2TLT PJB 2PHB 3L44 F<B m n oLK PJB
2T 2PHB KLMq 1 KL4o F;B oPHB KLp4 1 KL4p F;B KPHB KLK4 1 KLo4 F;B 2PHB KLoo F<B m n 2TLT PJB 2PHB
KL2K 1 qLMp F;B KPHB qL4q F<B m n 2qLo PJB 2PHB qLp2 1 qL32 F;B 2PHB qL4M F?B qPHB qL4p F?B qPHB
qLKo 1 qLqo F;B oPHB oL43 1 oL3q F;B KPHB oL2p 1 oLT4 F;B oPHB 2LMK 1 2L4o F;B oPHB 2L2o 1 2LT3
F;B qPHB 2LT3 1 TLM4 F;B 2TPHB TLMq F?B qPHL
12341
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2J3KLK MCNOP NL 2O QCR EKSS COIA C87T=6UV1WXYZ[Z\]^_Z`WaZbZcZd]XZefaZ_eYaZ\]_gZ`WaZbZcZd]_Z
OIA 2OGA hLiS E;A j k 4LS OIA 2OGA hL3J 1 hL32 E:A 2OGA hLJl E;A j k hLi OIA JOGA hL2J E;A j k iLS
2S OIA JOGA hLSi E;A j k iLh OIA JOGA 3L34 E;A j k 4LS OIA 2OGA 3L3S E;A j k iL4 OIA 2OGA KL33 E7A j k
3L3 OIA KOGA KLKS 1 KLl2 E:A 3OGA KLSK E;A j k 2JL3 OIA JOGA lLi4 1 lLiS E:A lOGA lLhh E7A j k 3Ll
OIA KOGA lL32 E;A j k 2LJ OIA lOGA lL3h E>A lOGA lLKi E;A j k 2lLK OIA iOGA JLi4 1 JL33 E:A 3OGA
2L3h E7A j k iLi OIA JOGA 2LJK 1 2L2l E:A lOGA 2LSi E>A lOGA 2LS3 E>A lOGA 2LSl E>A lOGA SL43 E>A
lOGL
12341
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6789:;9<=>89?@ A'B C &B >7< &D2 EF GHF6I ;JK 22L2M4 NEOPQ OM 2P RES GT44 EPKB E98U>7VW1
XYZ[\[]^_`[aXb[c[d[e^e[fgb[_fZb[]^_h[aXb[c[d[i^e[fgb[_fZb[j^`_[aXb[c[d[kMT PKB kPIB 3M4l G<B m n kMk
PKB 2PIB 3Mkl 1 3M2l G;B 4PIB 3M2k G<B m n oM4 PKB kPIB pM3L G<B m n 24M4 PKB 2PIB pMpL 1 pM4k G;B
24 kPIB TMl4 G?B 2PIB TMol 1 TMoL G;B 2PIB TMp4 1 TM4p G;B 2PIB TM4T 1 TMTL G;B kPIB TMT2 G?B 2PIB
TML4 G<B m n lMl PKB 2PIB TMkk G<B m n lMl PKB 2PIB TM2k 1 LMl3 G;B kPIB LMoL G<B m n 2LMk PKB 2PIB
LM34 G<B m n 22Mo PKB 2PIB LMp4 1 LMp2 G;B 2PIB LM4l G?B LPIB LM43 G?B LPIB kMop 1 kMp4 G;B TPIB
kMkL G?B kPIB 2M24 1 4Ml4 G;B 2LPIB 4MlL G?B LPIM
12341
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6789:;9<=>89?@ A&B C %B >7< 1 DE FGE6H ;IJ 22K2LM NDOPQ OL 2P RDS FTUU DPJB D98V>7WX1
YZ[\]\^_`a\bYc\d\e\`_a\fgc\hf[c\^_ij\bYc\d\e\j_k\fgc\hf[c\l_mZ\bYYc\d\e\^_^c\`_a\fgc\hf[c\l_mU F<B n
o pLT PJB 2PHB 3LpK F<<B n o qLTB KLK PJB TPHB 3L2p F<B n o qL2 PJB pPHB rLrq F<B n o qLM PJB 2PHB
rL5T F<B n o pLT PJB 2PHB TLMK 1 TLqK F;B pPHB TL52 F<<B n o qLpB TLU PJB pPHB TLKT F?B 2PHB TLp3 1
2U TL2q F;B 2PHB TL2p 1 KLMT F;B TPHB KLqK F<B n o 2KLp PJB 2PHB KLr5 1 KLrU F;B 2PHB KL5M F?B KPHB
KL5r F?B KPHB pLq5 1 pLrp F;B TPHB pLU2 F<B n o 22LU PJB 2PHB 2L2q F<B n o 2KLM PJB 2PHB 2L2U 1
ULMT F;B 2KPHB ULMp F?B KPHL
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pU 6789:;9<=>89?@ A&B C 4B >7< 1 DE FGE6H ;IJ 2255Lr NDOPQ OL 2P RDS FTUU DPJB WX1
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pPHB 3LpT F<B n o 3LM PJB pPHB 3L2K F<B n o qL2 PJB pPHB rLrM F<B n o MLU PJB 2PHB rLr5 F<B n o pL5
PJB 2PHB rL2K F88B n o 55LKB KLM PJB 2PHB TL5q 1 TLTp F;B TPHB TLK5 F?B 2PHB TLp3 1 TL2q F;B 2PHB
TL2r 1 KLM5 F;B TPHB KLqT F<B n o 2KLK PJB 2PHB KLrK F?B pPHB KLrU F?B KPHB KL53 F?B KPHB pLqr 1
12321
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6 8 35S 8 4 8 S5S 1 S5S2 678 4 8 S593 1 S54 678 4 8 S543 1 S522 678 S 8 95 2 6 8
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lMmC nM4 PLC 2PJC 3M4l H=C o p lMT PLC nPJC 3M4n H=C o p 3Ml PLC nPJC 3Mnn H=C o p lMU PLC nPJC mMln
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5MUn H<C 2PJC TM3T 1 TMm3 H<C 2PJC TMm5 1 TM54 H<C nPJC TM5U H@C 2PJC TMTT H=C o p qMq PLC 2PJC
TM42 H=C o p 2UMU PLC 2PJC TM24 H=C o p 24MT PLC nPJC 4Mq4 H=C o p 24M4 PLC 2PJC 4Ml4 1 4M3n H<C
nPJC 4Mmq H@C 4PJC 4Mmm H@C 4PJC nMqT 1 nM3n H<C nPJC nM44 H@C nPJC 2M2m H@C 4PJC 2M2T H@C 4PJC 2M22
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12341
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6 + $(()( /( 1(. 1($-(%( 3 :=>?9:@A B+C D C ?8= *+3 EF GHF7I
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2V RKC 2RIC nN35 G=C k l mN3 RKC 2RIC 5NVV 1 ONm2 G<C ORIC ON4L 1 ONn4 G<C ORIC ON5O 1 ONLm G<C LRIC
ONLL 1 ONM3 G<C 2RIC ONM2 1 ONVO G<C nRIC LNmO G=C k l 2LN2 RKC 2RIC LN32 G@C LRIC LNnn G@C LRIC
LN52 1 LNLm G<C 5RIC LNVV 1 MN3M G<C ORIC MNL3 1 MN22 G<C ORIC MNVL 1 2N4O G<C ORIC 2N2n G@C LRIC
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12341
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"#$%&%defg%h""i%j%k%feli%men%opi%qo$i%deqd%h"i%j%k%gel%opi%qo$i%deqq%h"i%j%k%fen%opi%qo$i%nenf%1
56 3 89 2 564 8 4 6 2 56 4 8 36 5677 8 36 56
8 36 5624 8 2 6 2 6 8 65 2 63 8 36 2
632 8 6 2 6 1 6 89 63 1 655 89 6 8 6 2 6
1 6 89 7 6 1 6 89 76 8 276 2 7653 1 765 89 76 8 7
76 8 7 7673 8 276 6 4 1 65 89 67 1 624 89 624 1 6 7 89
262 8 7 262 8 7 2622 8 7 26 7 8 7 6 2 8755 !1"#$%&%1
556 155657 1556 1 6 4 8 4 6 2 6 122 6 6
12341
56789 5
! "#$#% & ' $()# * + ! "#$#, -)
0 + + + $ ! "#$# $#. % + / #. (- / / +
()(, 1 1 #2/3 3 4 ' (- + ' $ - / - , -) / + / $ #.# $ ! "#$#
* % '$#'(- * * #.( 5 * $(()( .( 1(- 1($,(%( 3
6789:;9<=>89?@ A*B C5B >7< / 3 DE FGE6H ;IJ 22K2L4 MDNOP NL 2O QDR FKSS DOJB D98T>7UV1
WXYZ[Z\]^XZ_W`ZaZbZc]\Zde`ZfdY`Z\]ghZ1 3LiK F;B 2OHB 3L23 F<B j k lLm OJB 2OHB 3L2m F?B 2OHB nLnl
2S F<<B j k 3L4B iLi OJB 2OHB nL02 F8B j k 0lLn OJB 2OHB nLmK F<B j k 3Li OJB iOHB nLil 1 nLiS F;B KOHB
nL23 F<B j k lL3 OJB 2OHB 4L3i F<B j k lL3 OJB 2OHB 4Lnm F<B j k 3Ln OJB 2OHB KLnn F8B j k nL4 OJB
iOHB KL4i F<B j k 4Lm OJB iOHB KL0m F<<B j k 3LmB 0L2 OJB iOHB KLKl 1 KLK2 F;B 2OHB KLmn 1 KLil F;B
2OHB KLin 1 KLSn F;B mOHB mLlm F<B j k 2mLi OJB 2OHB mL4l F?B mOHB mL43 1 mL42 F;B KOHB mLSS F<8B j
k 2SLiB 4Lm OJB 2OHB iLlK 1 iLni F;B KOHB iLSl 1 2Ll3 F;B 2OHB 2L2n F?B mOHB 2L20 F?B mOHB 2L2i F?B
mOHB 2LSm F?B mOHL 2lo QDR Fmnn DOJB D98T>7UV1WXYZ[Z1nnLmlB 1nnLn2B B 1l4L3n F<B j k
0lLn OJHB 1220LS2L
12341
56789 5
! "#$#% & ' $()# * + ! "#$#, -)
0 + + + $ ! "#$# $#. % + + #. (- / / +
()(, 1 1 #2/3 3 4 ' (- / ' $ - / - , -) / + / $ #.# $ ! "#$#
* % '$#'(- * * #.( 5 * $(()( .( 1(- 1($,(%( +6 3
789:;<:=>?9:@A B*C D5C ?8= 3 EF GHF7I <JK 22L2MN OEPQR PM 2Q SET GLUU EQKC E:9V?8WX1
YZ[\]\^_`Z\aYb\c\d\e_f\ghb\ig[b\^_jf\1 3Mkl G<C 2QIC 3M24 G=C m n lML QKC 2QIC 3M2N G@C 2QIC 4M4L
2U G==C m n 3MlC kMN QKC 2QIC 4M02 G9C m n 0lM4 QKC 2QIC 4MNL G=C m n 4Ml QKC kQIC 4MkL G==C m n 2kM4C
3Mk QKC LQIC 4M23 G=C m n 2UM2 QKC 2QIC oM3L 1 oM4o G<C kQIC 0MU3 1 LMlN G<C kQIC LMo0 1 LM0o G<C
kQIC LM0U 1 LML2 G<C 2QIC LMNl 1 LMk4 G<C 2QIC LMk2 1 LMUN G<C NQIC NMlN G=C m n 2NMk QKC 2QIC
NM43 1 NMo3 G<C LQIC NMo4 G@C NQIC kMl0 1 kM4N G<C LQIC kM22 G=C m n 22M2 QKC 2QIC 2M24 G@C NQIC
2M20 G@C NQIC 2M2k G@C NQIC 2MUN G@C NQIM 2lp SET GN44 EQKC WX1YZ[\]\144MNlC 144M4kC 1
44MlNC 1loM34 G=C m n 0lM4 QKIC 1220MUk
12341
56789 5
!"#"$ % & #'(" ) * !"#"+ ,(
/ * * * # !"#" #"- $ ) "- ', . .
'('+ 0 0 "1.2)2 3"0 ', . & # $ , , + ,( . * . # "-"
# !"#" ) $ &#"&', ) ) "-' 4 ) #''(' -' 0', 0'#+'$' * 2
56789:8;<=78>? @)A B4A =6; 42 CD EFD5G :HI 22/JKL MCNOP NK 2O QCR ESTT COIA C87U=6VW1
XYZ[\[]^_Y[`Xa[b[c[d^e[fga[hfZa[]^_i[`ja[kfZa[]^h][`Xa[b[c[l^k[fga[hfZa[]^hi[`ja[hfZa[e^_h[`ma[b[c[
2T /LKn OIA 2OGA nKoS E;A p q 3Kr OIA rOGA nKrS E7A p q 3K2 OIA SOGA nK23 E;A p q LKL OIA 2OGA JK3r E;A
p q LKL OIA 2OGA /KTT 1 SKLr E:A rOGA SK3S 1 SKnn E:A rOGA SKSS E;A p q LKL OIA 2OGA SKo2 E;A p q
2TKT OIA 2OGA SKr2 1 SKTn E:A oOGA oKnL 1 oKnT E:A 2OGA oKJL E>A oOGA oKJJ E>A oOGA oK/r 1 oKS2 E:A
rOGA rKLJ 1 rKJJ E:A SOGA rKr2 E;A p q 22Kr OIA rOGA 2KLL E;A p q LK2 OIA rOGA 2K2n E>A oOGA 2K2S
E>A oOGA 2K22 E>A oOGA 2KTo E>A oOGK 2Ls QCR Eonn COIA VW1XYZ[\[1nnKoLA 1nnKnrA 1nnK3JA 1
2/ LJK3n E;A p q /LKn OIGA 122/KToK
12331
56789 5
! "#$#% & ' $()# * + ! "#$#, -)
+ % . #/ (- 0 #/# 0 . ()(, 1 1 #20303 4-#-(- 0 ' $ - 0
- , -) + + + $ ! "#$# $#/ % 0 + 0 $ #/#
$ ! "#$# * % '$#'(- * * #/( . * $(()( /( 1(- ( +*
6789:;9<=>89?@ A*B C.B >7< 0.3 DE FGE6H ;IJ 2KK4LM NDOPQ OL 2P RDS FTUU DPJB D98V>7WX1
YZ[\]\^_`Z\aYb\c\d\e_^\fgb\hf[b\^_ij\aYb\c\d\i_i\fgb\hf[b\^_hj\aYb\c\d\k_l\fgb\hf[b\^_hi\amb\hf[b\
nL43 1 nL33 F;B 2PHB nL53 F8B o p 54Ln PJB 2PHB nLM3 1 nLMM F;B KPHB nLK5 F<<B o p 3LKB 5L3 PJB TPHB
2U nL23 F<B o p 4L4 PJB 2PHB qL3U F<B o p 4L4 PJB 2PHB TL3M 1 TLn5 F;B 2PHB TLq5 F<B o p 2ML5 PJB KPHB
TL5T F8B o p qL3 PJB KPHB TLTM F<B o p 4Ln PJB 2PHB TLM5 1 TL2q F;B MPHB TL2M F8B o p 22LM PJB KPHB
TLUK F<B o p 2KLT PJB UPHB ML4M F<B o p 2ML2 PJB 2PHB MLnK F<B o p 2ULT PJB KPHB MLq4 F<B o p KL2
PJB MPHB MLqq F?B MPHB ML5M 1 MLTT F;B 2PHB KL44 1 KLn2 F;B TPHB KLTn F<B o p 22Lq PJB KPHB 2L2n
F?B TPHB 2L2T F?B MPHB 2L22 F?B TPHB 2LUn F?B 5PHB 2LUM F?B MPHL 24r RDS FMnn DPJB D98V>7WX1<TH
]\1nnLM3 B 1nnLn2 F<B o p 5Lq PJHB 1nnL4n B 14qL3n F<B o p 54Ln PJHB 1225LUK L
12341
56789 5
! "#$#% & ' $()# * +) , , ,
$ ! "#$# $#- % , #- (+ . . ()(* / / #0.121 3#/ (+
4 . ' $ + . + * +) . , . $ #-# $ ! "#$# 2 % '$#'(+ 2 2
#-( 5 2 $(()( -( /(+ ( ,. 1 6789:;9<=>89?@ A2B C B >7< .1 DE
FGE6H ;IJ 2223K3 LDMNO MK 2N PDQ FR44 DNJB D98S>7TU1VWXYZY[\][Y^_`YabX`Y[\cdY^V`YeYfYc\]Y
NJB 2NHB gK43 F<B h i 3Kj NJB 2NHB gK4k F?B 2NHB jKk3 F<<B h i gK3B lKm NJB 2NHB jK4R F<B h i gK2
NJB lNHB jKRg F8B h i 43K3 NJB 2NHB jKR2 F<B h i gK2 NJB lNHB jKmm F<B h i jKg NJB lNHB jKl2 F<B h i
24 gK4 NJB lNHB jK2R F<B h i 3Kk NJB 2NHB kKgk F<B h i gK3 NJB 2NHB kKjk F<B h i 3Kg NJB 2NHB RK3k F8B h
i jKk NJB lNHB RKg2 F<<B h i gKmB 4K2 NJB lNHB RKR4 1 RKm2 F;B mNHB RKl4 F<B h i 3Kk NJB 2NHB RK24
F?B mNHB mK3g F<B h i 2mKl NJB 2NHB mKgk F<B h i 2mK4 NJB 2NHB mKjR F<B h i gKm NJB 2NHB mKkg F?B
mNHB mKk4 F?B mNHB mKmj F<B h i 2mK3 NJB lNHB lK34 1 lKkj F;B RNHB lKm4 1 lK23 F;B lNHB lK4j F<B h
i gKk NJB lNHB 2K2l F?B mNHB 2K43 F?B mNHB 2K42 F?B mNHB 4Kg4 F?B mNHK 23n PDQ Fmjk DNJB
24 D98S>7TU1VWXYZY1jjKR2 B 1jjKkk B 1jjKjm B 13kK4j F<B h i 43K3 NJHK
12341
56789 5
! "#$ % %& #"#' ( ) ! "#$ % % '*
" %+ "#, ( ! ( #%+% ! - " %$ -' ) .- %' (
3 "#-*- #. . %/(0)0 1%. -' ( & #"#' ( ' '* ) %+- 2 )
--*- +-" .-' .- -,- ! 0 7:;<67=>? @ <5: ( "#$ % %
-, ( ) "#%+- % % -' ) & #"#' 0 AB CDB4E 9FG 2HIJKL2 MANOP NK 2O QAR CSHH
AOG@ A76T<5UV1WSE XYZ[\][Z^_`Za b 2K3 OG@ 2OE@ IKLS c IKHJ C9@ LOE@ dKd3 Ce@ a b IKf OG@ LOE@
dKSL c dK2S C9@ dOE@ JK33 C6@ a b 2HK3 OG@ 2OE@ SKIH c SKJ3 C9@ fOE@ SKL3 c fKIS C9@ 2HOE@ fKdd c
2H fK3I C9@ 3OE@ fK23 C6@ a b 2LKf OG@ 2OE@ fKHL c LKd3 C9@ JOE@ LKf2 c 2KdJ C9@ SOE@ HKId C:@ a b
LdKJ OG@ LHOEK
12321
56789 5
! "#$#% & ' $()# * + ! "#$#, -)
1 + + + $ ! "#$# $#. % + / #. (- 0 0 /
()(, 2 2 #30404 5-#-(- 0 ' $ , -) 0 + 0 $ #.# $ ! "#$#
* % '$#'(- * * #.( / * $(()( .( 2(- 2($,(%( + 4
6789:;9<=>89?@ A*B C/B >7< 4 DE FGE6H ;IJ 22K3LM NDOPQ OL 2P RDS FTUU DPJB D98V>7WX1
^_`a\bcd\ef[d\^_a^\bcd\ef[d\^_eZ\bYd\g\h\i_`\fjd\ef[d\^_ek\bcd\ef[d\l_l^\bYd\g\h\i_`\fjd\ef[d\
2U mL1M F8B n o 13Lm PJB 2PHB mLp1 F<B n o mL4 PJB 4PHB mL4T F8B n o mLM PJB TPHB mL2T F<B n o 3LM PJB
2PHB mLU2 F<B n o ML3 PJB 2PHB KLm3 F<B n o 2ULU PJB 2PHB TLm3 F8B n o mLM PJB 4PHB TL1U 1 TL4T F;B
1PHB TL23 1 TLU1 F;B 4PHB pL3p F<B n o 2pL4 PJB 2PHB pLm3 1 pLKp F;B 3PHB pL2T F<B n o 24Lp PJB
4PHB pLUU 1 4Lm4 F;B TPHB 4LTK F?B 4PHB 4L2p 1 2L34 F;B 4PHB 2L2m F?B pPHB 2L21 F?B pPHB 2L24 F?B
pPHB 2LUp F?B pPHL 23q RDS FpmK DPJB D98V>7WX1YZ[\]\1mmLpK B 1mmLmU B 1mmLmM B 13KLMM F<B n o
21 13LM PJHB 1221LU2L
12341
6789 6
!"#"$ % & #'(" ) * !"#"+ ,(
0 * * * # !"#" #"- $ . * . # "-" * / & # , ) . /
'('+ 1 1 "2.3.3 4,",', . & # , . , + ,( # !"#" )
$ &#"&', ) ) "-' / ) #''(' -' 1', 1'#+'$' ** 3
56789:8;<=78>? @)A B/A =6; C3 DE FGE5H :IJ 223KLM NDOPQ OL 2P RDS FTKK DPJA D87U=6VW1
XYZ[\[]^_`[aXb[c[d[e^f[ghb[igZb[]^if[1 jLK3 F:A kPHA ML3j F;A l m kLk PJA 2PHA MLj2 F;;;A l m 3L2A
2K MLKA 2Lj PJA 2PHA MLMn F;;;A l m nLTA 2LjA KLM PJA 2PHA ML0M F;;A l m 3LkA kL4 PJA 2PHA ML0K F7A l m
03LM PJA 2PHA ML4K F;A l m ML3 PJA kPHA MLkn 1 ML2j F:A 0PHA ML24 F;A l m 3L3 PJA 2PHA nL34 F;A l m
3L4 PJA 2PHA nLM3 F7A l m nLM PJA 2PHA TL0K F;A l m 24L4 PJA kPHA TLTn 1 TL4j F:A 2PHA TLkT F;A l m
24L2 PJA kPHA TLkK 1 TLK0 F:A kPHA 4L34 F;A l m 24L2 PJA 2PHA 4LMM 1 4LnM F:A 0PHA 4Lnn F>A 4PHA
4L0j 1 4LTn F:A kPHA 4L4j F;A l m 24L4 PJA kPHA kL3n 1 kLM2 F:A TPHA kL40 F>A kPHA kL2T F7A l m 4Lk
PJA kPHA 2L2M F>A 4PHA 2L20 F>A 4PHA 2L2k F>A 4PHA 2LK4 F>A 4PHL 23o RDS F4Mn DPJA D87U=6VW1
1MML4T A 1MMLnn A 1MML3M A 13nLjM F;A l m 03Ln PJHA 1220LKK F;A l m jLM PJHL
12341
56789 5
!" # $%!&!'%" " ()#*#* +,(,!, # - .%$%, #
, ' ,& $%/ 0(.(1 2 - .!&( 3 $%/ 0(.(' ,&
.%/ 0(.( $.(4 $%1 # # .%(4( .%/ 0(.( 3
1 -.(-!, 3 3 (4! 3 .!!&! 4!$ "!, "!.'!1! *
6789:;9<=>89?@ A3B C B >7< # * DE FGE6H ;IJ 2255K3 LDMNO MK 2N PDQ F4RR DNJB D98S>7TU1
VWXYZY[\WWY]^_Y`aX_Y[\bcY]V_YdYeYf\gYah_Y`aX_Y[\biY]^_Y`aX_Yc\ffY]V_YdYeYj\iYah_Y`aX_Yc\cgY]V_YdYeY
3K4 NJB 2NHB kK43 F8B l m 53Kk NJB 2NHB kKno F<B l m kK3 NJB nNHB kKnR 1 kKRp F;B 5NHB oKkn F<B l m
2R 2RKn NJB 2NHB 4Ko2 F<B l m 2pK5 NJB 2NHB 4Kpq 1 4Kn3 F;B pNHB 4Kn4 1 4K2k F;B 2NHB 4KR4 F<8B l m
n3K4B 2pK3 NJB 5NHB pKqp F<B l m 2pK2 NJB 2NHB pKoo 1 pKo2 F;B 2NHB pK53 F?B pNHB pK5k F?B pNHB
pK44 1 pKno F;B 4NHB nKqk 1 nKon F;B oNHB nK22 F?B pNHB 2K35 F?B pNHB 2KqR F?B pNHB 2KRq F?B pNHB
2KR5 F?B pNHB 2KRn F?B pNHB RK34 F?B pNHK 23r PDQ Fpkk DNJB TU1VWXYZY1kkKpq B 1kkKkR B 1
kkKqq Fsrt u9>vHB 13oKqq F<B l m 53Kq NJHB 1225KRn K
12341
56789 5
!" # "$"%&' ' (#)*) + ' ", # - .&/&, #
, % ,$ /&0 1 . 2 3 - ."$ * /&0 1 . % ,$
4 .&0 1 . /. ! /&2 # # .& ! .&0 1 . *
2 -. -", * * !" 4 * .""$" !"/ '", '".%"2" )
56789:8;<=78>? @*A B4A =6; #) CD EFD5G :HI 22JJKLMCNOP NK2O QCR ESJJ COIA C87T=6UV1
WXYZ[Z\]XXZ^_`ZabY`Z\]aaZc LKJS E:A dOGA LKJe E>A 2OGA fKfe E;A g h 3KS OIA 2OGA fKS2 E7A g h 43KL
OIA 2OGA fKdi E;A g h fKd OIA eOGA fK24 E7A g h fKi OIA 4OGA iK3S E;A g h 3Kd OIA 2OGA SKSf c SKeL
2J E:A dOGA SKef c SKeJ E:A 2OGA SKdS c SK2L E:A 2OGA SK2d c eK3i E:A dOGA eKLS E;A g h 2eK2 OIA
2OGA eKfd E;A g h 2dKd OIA dOGA eKii c eKi2 E:A 2OGA eK43 E>A eOGA eK4f E>A eOGA eK2L c eK2d E:A
dOGA dKLi c dKie E:A 4OGA 2K3f c 2KL4 E:A dOGA 2KL2 c 2Kfe E:A dOGA 2KJL E>A eOGA 2KJ4 E>A eOGA
2KJd E>A eOGA JK3S E>A eOGK 23j QCR Eeff COIA UV1WXYZ[Z1ffKeL A 1ffKfJ A 1ffK3S A 13iKLL
E;A g h 43Kf OIGA 1224KJd K
12341
56789 5
! "#$#% & ' $()# * + ! "#$#, -)
0 + + + $ ! "#$# $#. % / % + #.# + /
$( $# % ()#1 * (2' $() - * ' - - , -) 3 + 3 $ #.#
$ ! "#$# * % '$#'(- * * #.( / * $(()( .( 4(- 4($,(%( + 5
6789:;9<=>89?@ A*B C/B >7< 5 DE FGE6H ;IJ 22KLM3 NDOPQ OM 2P RDS FTUU DPJB WX1
YZ[\]\^_ZZ\`ab\cd[b\^_ef\`Yb\g\h\f_Z\dib\cd[b\^_ej\`ab\cd[b\k_kj\`ab\cd[b\k_lj\`Yb\g\h\^_j\dib\md[b\
2U LM02 F<B n o pMK PJB qPHB LMT2 F<B n o 03ML PJB 2PHB LMKq 1 LMq0 F;B qPHB LM24 F<<B n o pMKB KMK PJB
TPHB LMU3 F<B n o 3M3 PJB 2PHB 4ML2 F<B n o 2UMU PJB 2PHB TMK3 1 TMKU F;B 2PHB TMKU 1 TM2L F;B
2PHB TM22 1 KM3L F;B qPHB KMpT F<B n o 2KMq PJB 2PHB KM4p 1 KM4q F;B 2PHB KM42 F?B KPHB KM0L F?B
KPHB KMUp F?B KPHB qMpq F<B n o LM3 PJB qPHB qMLp 1 qM42 F;B qPHB 2MUp F?B KPHB 2MU0 F?B KPHB 2MUq
F?B KPHB UM3T F?B KPHM 23r RDS FKLL DPJB D98V>7WX1YZ[\]\1LLMK3 B 1LLMLU B 1LLMpq B 134MpL F<B n
o 03ML PJHB 1220MUU M
12341
56789 5
! "#$#% & ' $()# * + ! "#$#, -)
+ + + $ ! "#$# $#. % + % /" !#- 0
()(, 1 1 #203*3 4#1 (- 0 ' $ , -) 0 + 0 $ #.# $ ! "#$#
* % '$#'(- * * #.( 6 * $(()( .( 1(- 1($,(%( 67 3
89:;<=;>?@:;AB C*D E6D @9> 0 3 FG HIG8J =KL 2244MN OFPQR PM 2Q SFT HNUU FQLD F;:V@9WX1
^_`Z\abc\de[c\^_fg\aYc\h\i\f_f\ejc\de[c\^_df\abc\de[c\k_kl\aYc\h\i\m_Z\ejc\de[c\k_`g\aYc\h\i\
53M4 QLD 2QJD 4Mnn H>D o p 4M3 QLD qQJD 4Mq5 H>D o p rMN QLD qQJD 4Mqq H>D o p rMU QLD qQJD sM32
2U H>D o p 3M2 QLD 2QJD NMNn HAD 2QJD NMn3 HAD qQJD NMnU HAD 2QJD NM2r 1 NMU2 H=D NQJD nM3n H>D o p 2nM2
QLD 2QJD nM4s 1 nM4U H=D 2QJD nMs3 HAD nQJD nMss HAD nQJD nMq2 H>D o p 22M3 QLD qQJD nMUN HAD nQJD
qM35 1 qM4U H=D NQJD qM2q 1 2M33 H=D qQJD 2Mrs H:D o p 4MU QLD qQJD 2M24 HAD NQJD 2M2N HAD nQJD 2M22
HAD nQJD 2MUn HAD nQJM 23t SFT Hn44 FQLD F;:V@9WX1YZ[\]\144MNU H>D o p 5Ms QLJD 144M42 D 144M3U
D 13sMrr H>D o p 53M4 QLJD 1225MU2 M
12341
56789 5
! "#$#% & ' $()# * + ! "#$#, -)
+ + + $ ! "#$# $#. % + #. (- / /
4 ()(, 0 0 #1/2*2 3#0 (- / ' $ - / - , -) / + / $ #.# $ ! "#$#
* % '$#'(- * * #.( 5 * $(()( .( 0(- 0($,(%( 5 2
6789:;9<=>89?@ A*B C5B >7< /2 DE FGE6H ;IJ 2244KL MDNOP NK 2O QDR FSTT DOJB D98U>7VW1
XYZ[\[]^Y_[`ab[cdZb[]^eY[1 4K24 F;B 2OHB 4KT4 F<B f g 3Kh OJB 2OHB 4KTh F<B f g TKi OJB 2OHB iKL4 1
iK4j F;B hOHB iK4T 1 iKSh F;B 2OHB iKS2 F<B f g 43Ki OJB 2OHB iKjh F<B f g iK3 OJB jOHB iK2L F<B f
2T g 4KS OJB jOHB iK2h F<B f g 4K2 OJB jOHB LKii F<B f g 4K3 OJB 2OHB LKi2 F<B f g 2TKT OJB 2OHB SK4i
F8B f g iKL OJB jOHB SKi2 F<<B f g 4KjB 4KT OJB jOHB SKhS F<B f g 3K3 OJB 2OHB SKjL F<B f g 2hK4 OJB
jOHB SKj2 F<B f g 2TKT OJB 2OHB SK22 1 hK3i F;B 4OHB hK4h F<B f g 2hKj OJB 2OHB hKLL 1 hKL2 F;B
2OHB hK43 F?B hOHB hK4i F?B hOHB hKj4 F<B f g 2hK3 OJB jOHB jK44 1 jKLh F;B SOHB jK23 1 jKT3 F;B
jOHB jKTj 1 2K34 F;B jOHB 2KT4 F?B hOHB 2KT4 F?B hOHB 2KTj F?B hOHB TK3S F?B hOHK 23k QDR Fhii
24 DOJB VW1XYZ[\[1iiKST B 1iiKij B 13LK4i F<B f g 43Ki OJHB 1224KTjK
12341
!"#"$ % & #'(" ) * + !"#", -(
4 #". $ + $ /! "- ) '(', 0 0 "1)2*2 3"0 '- )
& # - ) - , -( ) + ) # "." # !"#" * $ &#"&'- * *
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FGE6H ;IJ 22KLMN ODPQR PM 2Q SDT FUVV DQJB D98W>7XY1Z[\]^]_`a[]1 NM2U F;B KQHB NM2V F<B b
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8 8657 767 86 8 565 5 8672 1 569 8 563 76
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76 7 S 643 RS cQ hiC 2 j kP] ]NcffM PN fRR NM lMfPNbfM6 adNMf 5 O NOM fMPgNcRQ
cmNbfM kP] gRQgMQNfPNM bQ Mf fM bgM lfM]]bfM PQ NOM fM]c bM kP] lbfcdcM no pji PQ NOM
2 lfR bgN SoRlOcSc M NR PddRf 0;06 CD EDF G 27767 HCI J I6 KCL 877 C
12341
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J9<A@;=;?74O3AH>F>CC2H>EGEGE>5=9<A@;=;>F>CCK756;Q3RN=?;43AHNK94;H>BGB>
J9K7563A?@5N4;3AH63J=NO943AH>B>63J=;Q3>F>CC2H>EGEGE>5=9<A@;=;>F>
& CCK756;Q3RN=?;43AHNK94;H>BGB>J9K7563A?@5N4NK9J;H?@53AHM6743AH756343AHM3=9J94>F>3AH>
BGS>J9NON?9R3RA;TBUFUIV;R5N47>S>RN=?;Q3AN57:CIPFNHU:W 76X 6 Y976'Z [\ :]BG 9 :2IPU:5^ _^W
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12341
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GHIJKJLMHNJOPQJRSIQJLMRLJOGQJTJUJVMWJSXQJRSIQJLMYLJOGQJTJUJZMHJSXQJRSIQJLMYWJOPQJRSIQJ[M\WJ1 35]]
] 8&F 4A;F 35E4 8.F 4A;F 352> 1 352= 8&F 2A;F 354E 8**F ^ _ 4E5>F `52 A4F EA;F a53b 8!F ^ _ >5a A4F
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45`] 8&F bA;F 454a 1 =5>3 8&F >A;F =5>E 8.F bA;5
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m6789 nnop qp rp p n n n st u 56789 v 9 w 9 + st u 6 9
+ + + 7 st u r 89 9 o o s56789 q n nn+ n+ n 67 w 9 +
4] s x s yw wz86 7 9 9 s s w 9 6789 9 6 9 w + w 7 s o n 7 st u
56789 9 767 86 6 9 5 76 n +w
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2= A4F 4A;F a5`] 8*F ^ _ 25` A4F 4A;F a532 8*F ^ _ >5> A4F 4A;F a5]= 8*F ^ _ `5> A4F 4A;F E5>= 1 E5`2
8&F 4A;F E5E> 1 E5bE 8&F aA;F E52` 8.F EA;F E524 8*F ^ _ 4=5= A4F 4A;F E5=] 8*F ^ _ 4b5= A4F 2A;F
b5`] 8*F ^ _ 4b52 A4F 4A;F b5aE 8.F 2A;F b5]> 8.F bA;F b5]3 8.F bA;F 25`` 1 253E 8&F bA;F 253E 1
25ab 8&F 4A;F 45=a 8.F bA;F 45=] 8.F bA;F 45=2 8.F bA;F =5>b 8.F bA;5
12341
4567894
! "#$#% & ' $()# * + , ! "#$#- .)
1 , , , $ ! "#$# $#/ % , *(0 ,(
% /( $#' $$# #2* 34' $$# + & ' $ . * . - .) * , * $ #/#
$ ! "#$# + % '$#'(. + + #/( 5 + $(()( /( 3(.
( , 6 789:;<:=>?9:@A B C D* ?8= 6 EF GHF7I <JK LLLMNO PEQRS QN LR TEU
GMVV ERKC E:9W?8XY1Z[\]^]_`ab]1 cNV1 G<C 2RIC cNVL G=C d e 2N3 RKC LRIC 3NfL G==C d e cNgC 2N2
LV RKC LRIC 3NMM G9C d e 1gNc RKC LRIC 3NOf G=C d e cN2 RKC 2RIC 3N2M G=C d e 3Ng RKC 2RIC 3NLO G=C d e
cNV RKC 2RIC 3NV1 G=C d e gNg RKC LRIC fNc1 G=C d e 2N3 RKC LRIC fN32 G=C d e LVNV RKC LRIC fNfM
G=C d e cNg RKC LRIC MNO1 G=C d e gNc RKC LRIC MN2L G=C d e LVNV RKC LRIC MNV1 G=C d e L2Nf RKC 2RIC
ONc1 G=C d e LONL RKC 2RIC ONf1 G@C LRIC ON1c G=C d e LVN3 RKC fRIC ONOf G=C d e LMNg RKC 2RIC 2NcM
G==C d e LcNgC gN2 RKC 1RIC 2N3V G=C d e LVN2 RKC LRIC LNVf G=C d e fNO RKC fRIC LNV2 G@C ORIC VNgO
L1 G@C ORIN
12321
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- - - %!" #$%$ %$0 !& - +)1 -) $0 )/ +
0) %$( %%$ $2+ 34( %%$ , ' ( %! !/ + / . /* + - + %!$0$
%!" #$%$ , & (%$()/ , , $0) 6 , %))*) 0) 3)/ 3)%.)&)
- 7 ;>?@:;AB C D E+ @9> F GH IJH8K =LM NN5O72 PGQRS Q7 NR TGU IVWW GRMD
G;:X@9YZ1[\]^_^`abc^d[e^f^g^hai^jke^hj]e^`abl^d[e^f^g^ham^jMD NRKD 3732 I>>D n o p7qD 272 RMD NRKD
37VV I:D n o 5q7p RMD NRKD 374O I>D n o p72 RMD 2RKD 3725 I>D n o 37q RMD 2RKD 37NV I>D n o p7W RMD
NW 2RKD 37W5 I>D n o q7q RMD NRKD O7p5 I>D n o 273 RMD NRKD O7pN 1 O7O3 I=D 2RKD V7O4 I>>D n o p74D 57N
RMD 2RKD V7VO 1 V74W I=D 2RKD V72N I>D n o NW7W RMD NRKD V7W5 I>D n o N474 RMD 2RKD 47p5 I>D n o
N472 RMD NRKD 47OV I>D n o V74 RMD ORKD 475q IAD 4RKD 4753 IAD 4RKD 4742 IAD 4RKD 27p3 1 27O2 I=D
VRKD N7WO I>D n o O72 RMD ORKD N7W2 IAD 4RKD W7q4 IAD 4RK7
12341
6789 6
! "#$#% & ' $()# * + ! "#$#, -)
+ + + $ ! "#$# $#. + /#'$#' 0 ()(, 1 1 #203*3 4#1 (- 0
' $ , -) % 0 + 0 $ #.# $ ! "#$# *
% '$#'(- * * #.( 6 * $(()( .( 1(- 1($,(%( ++ 3
789:;<:=>?9:@A B6C D0 ?8= **3 EF GHF7I <JK LL42M5 NEOPQ OM LP RES G4TT EPKC E:9U?8VW1
XYZ[\[]^YY[_X`[a[b[c^d[ef`[geZ`[]^hc[_i`[geZ`[]^cd[_X`[a[b[j^k[ef`[geZ`[]^cl[1 mMT2 G<C LPIC 3Mn3 1
3M5T G<C LPIC 3M5T 1 3M4o G<C TPIC 3M4L G@C TPIC 3M2p 1 3M2T G<C 2PIC 3ML4 G==C q r LoM3C mMo PKC
LT oPIC nM3o G==C q r LmM5C pMn PKC LPIC 4Mo4 G9C q r 5M2 PKC oPIC 4MoT 1 4ML5 G<C oPIC 4MLo 1 oMp4 G<C
oPIC oMm4 G=C q r LoM2 PKC LPIC oM5m G=C q r LTM5 PKC nPIC oML3 G=C q r 2M4 PKC LPIC 2MpL 1 2Mn4
G<C oPIC 2ML4 G=C q r LLM4 PKC 2PIC LMp5 G=C q r mMn PKC LPIC LMo3 G=C q r nM4 PKC nPIC LML2 1 TMp3
G<C pPIC TMp4 G@C oPIM
6789 6 s
! "#$#% & ' $()# * + ! "#$#, -)
+ 0 ()(, 1 1 #203*3 4#1 (- 0 ' $ , -) + + +
$ ! "#$# $#. % 0 + 0 $ #.# $ ! "#$# * % '$#'(- *
2T * #.( 6 * $(()( .( 1(- ( +6 3 789:;<:=>?9:@A B6C D0 ?8= * 3
EF GHF7I <JK LL2mMn NEOPQ OM LP RES G4TT EPKC E:9U?8VW1XYZ[\[]^YY[_X`[a[b[c^d[ef`[geZ`[
mMLp G=C q r 2M2 PKC LPIC mMTn G=C q r 2LM3 PKC 2PIC 3Mno 1 3M5o G<C LPIC 3M4L G@C LPIC 3M2m 1 3M2L
G<C 2PIC 3ML4 G==C q r LoMpC mM2 PKC 4PIC nM3o G==C q r LmMmC pM5 PKC 2PIC 4M42 1 4MoT G<C LPIC
4MoT 1 4MLm G<C oPIC 4MLo G=C q r 4Mo PKC 2PIC 4MT2 G=C q r L2Mn PKC 2PIC oMm4 G=C q r LoM2 PKC
12341
5678 9 4 8 5 4 6 8 3678 9 8 3 9 6 8 2678 2 2 1 2 32 8 9678 2 32 1 2 5 8
5678 2 2 1 2 59 8 2678 5 8 3 6 8 2678 5 92 8 3 9 6 8 9678 5 55 1 8 678
8 967
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45=>=A5E'E(8FDG?G0H8E%=B3D3'(2<'9545B3D3'(2$%&'B'(2A$B>'(23D-@-0D3%958C83+3*003%956(78983
?3:$%&'(<98<=B3?3'(23?38C=31-I0?3%$%9==>=&$C=4$E=B3013'(2E=9A=:=%$)*0@.2
JK LM L NO L P - OK ),?SG)TU VUJ7 W 5559 XTY6Z Y 56 [T\ T6 8 TL ]OK^_1
`abcdcefagch`icjckclfmcnoicpnbicefqac1 5 8 5678 8 9 6 8 5678 9 8 5678 3 9 1
3 4 8 5678 3 5 8 5678 3 2 1 3 25 8 2678 3 5 8 5 48 2 6 8 4678 3 8
54 54 48 6 8 2678 9 8 6 8 5678 2 8 53 38 55 6 8 9678 2 8 59
6 8 678 9 9 8 59 2 6 8 5678 9 4 8 5 6 8 3678 9 5 8 5678 9 1 2 8 678
2 4 1 2 4 8 678 2 95 1 2 59 8 2678 2 4 1 5 8 2678 5 59 1 8 678 8 967
12341
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!" # $ % & ' ( $ ) *+ !" # $ , )
* & $ + - *- ! ) ,!. . / 0 0 1 . ( $! !
2 & (& * * $!" # $ * !% &
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,# . $, % +3 0 7:;<67=> ? @ A * <5: 0 BC DEC4F 9GH I2JKLJ MBNOP
NL IO QBR DSTT BOH@ B76U<5VW1XYZ[\[]^_`[aXb[c[d[e^`[fgb[_fZb[]^hi[aXb[c[d[i^Y[fgb[_fZb[]^he[
D:@ j k 2Ll OH@ IOF@ 3L22 D::@ j k lLK@ 2LS OH@ IOF@ 3LS2 D6@ j k 2KLK OH@ IOF@ 3LJ3 D:@ j k lL2 OH@
IT 2OF@ 3L2I D:@ j k 3LK OH@ 2OF@ 3LI2 D:@ j k 3LK OH@ 2OF@ 4Ll2 D:@ j k 2Ll OH@ IOF@ 4L4I D:@ j k KLT
OH@ IOF@ 2L2K D:m@ j k I3L2@ 2L3 OH@ 2OF@ SL34 1 SL3J D9@ SOF@ SL43 D6@ j k 4LS OH@ 2OF@ SL24 D:::@
j k ITLJ@ 3LJ@ 2LS OH@ 2OF@ SL22 1 SLS2 D9@ SOF@ SLJ2 D=@ IOF@ SL2T D=@ IOF@ SLII 1 SLTT D9@ 2OF@
JLKT 1 JL34 D9@ JOF@ JL33 1 JL4T D9@ 2OF@ JLTl 1 2LK3 D9@ 2OF@ 2LlK 1 2L32 D9@ JOF@ 2L3J 1 2L4J
D9@ IOF@ ILKT 1 ILlI D9@ 2OF@ IL4l 1 IL24 D9@ 2OF@ ILTK D=@ JOF@ ILT3 D=@ JOF@ ILTJ D=@ JOF@ TLK2
I2 D=@ JOFL
12341
4567894
!" ! # ! "$% & ' ( )*+ , " - .%
1 ( ( ( "*+ , " )" / )*0 ( / $. & &
)*$%$-* 2&3'3 4 $. & ! "*)*. & . - .% & ( & "* / "*+ , "
' 0 !" !$. ' ' /$ 5 ' "$$%$ /$) $. $"-$0$ 56 3
:=>?9:@A B &C D& ?8= &3 EF GHF7I <JK LLMNOP QERST RO LS UEV GMPP ESKC E:9W?8XY1
Z[\]^]_`ab]cZZd]e]f]a`gd]h`_]ijd]ki\d]_`k_]cZd]e]f]b`a]ijd]ki\d]l`lh]cmZd]e]f][`bd][`[d]a`g]ijd]ai\d
LP 3Ono 1 3O23 G<C MSIC 3O22 G=C p q rOL SKC 2SIC 3OLN G=C p q oOo SKC LSIC NOrN G=C p q rOo SKC LSIC
NOrP G=C p q oOo SKC LSIC NONM G=C p q 2OM SKC LSIC MOoN G==C p q rO2C 3OP SKC 2SIC MOrL G==C p q
rOnC 1OL SKC 2SIC MOMN 1 MOML G<C LSIC MOno 1 MOnn G<C LSIC MOnL G=C p q LPOP SKC LSIC MOLo 1 MOP3
G<C MSIC nOon G=C p q LnO2 SKC LSIC nO3N 1 nO3P G<C LSIC nONo G@C nSIC nONN G@C nSIC nOMP 1 nOnM
G<C 2SIC 2Oo1 1 2O3P G<C MSIC 2OnP 1 2OLr G<C 2SIC 2OL2 1 2OPL G<C 2SIC LO22 1 LOPM G<C LnSIC
L1 LOP2 G@C nSIO
12331
56789 5
! "#$#% & ' $()# * + , ! "#$#- .)
, , , $ ! "#$# $#/ % + #/ (. * *
4 ()(- 0 0 #1*2+2 3#0 (. * ' $ % . . - .) * , * $ #/#
$ ! "#$# + % '$#'(. + + #/( 5 + $(()( /( 0(. 0($-(%( 5 2
6789:;9<=>89?@ A B C* >7< 52 DE FGE6H ;IJ KK4LMN ODPQR PM KQ SDT FNUU DQJB WX1
YZ[\]\^_Z`\abc\de[c\^_f^\aYc\g\h\i_Z\ejc\ke[c\^_fk\aYc\g\h\d_^\ejc\ke[c\l_ZZ\aYc\g\h\mi_^ QJB KQHB
3Mn4 F<B o p 4M2 QJB 2QHB 3M24 F<B o p 3Mq QJB 2QHB 3MKN F<B o p 4MK QJB 2QHB 3MUn F<B o p qMq QJB
KU KQHB LM4N F<B o p 2M3 QJB KQHB LM3K F<B o p qMq QJB KQHB NM43 F8B o p 3ML QJB 2QHB NM32 F<<B o p 4M2B
NMq QJB 2QHB NML3 F?B KQHB NMN2 1 NM2q F;B KQHB NM24 1 NMK4 F;B KQHB NMKK 1 nMq4 F;B NQHB nM44 F<B
o p KnMK QJB KQHB nMLq 1 nML2 F;B 2QHB nM4q F?B nQHB nM43 F?B nQHB nMNK 1 nM24 F;B 2QHB 2M43 1 2M34
F;B nQHB 2ML4 F<<B o p K2MLB qMK QJB KQHB 2MK4 1 2MUL F;B 2QHB KMq4 1 KM4n F;B 2QHB KMU3 F?B nQHB
KMU4 F?B nQHB KMU2 F?B nQHB UMqn F?B nQHM
12341
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! "#$%$&#' ' ()!* * +(' $, ! - .#/#"#,
, & ,% "#0 1(.(/ 2 - .$%( ! 3 "#0 1(.(& ,%
3 3 3 .#0 1(.( ".(4 "#/ ! 3 ! .#(4( .#0 1(.(
/ -.(-$, (4$ 6 .$$%$ 4$" '$, '$.&$/$ 6 *
:=>?9:@A B C D! ?8= !3* EF GHF7I <JK LLMMNO PEQRS QN LR TEU GOMM ERKC
E:9V?8WX1YZ[\]\^_Z`\abc\de[c\^_f^ G=C g h 4N2 RKC LRIC iNML G=C g h 2N3 RKC LRIC 3NOO G=C g h 54Ni
RKC LRIC 3Njk G=C g h iN2 RKC 2RIC 3N25 G=C g h 3N4 RKC 2RIC 3NLO G=C g h iNL RKC 2RIC 3NMj G=C g h
LM iN5 RKC LRIC kNiO G=C g h 2Ni RKC LRIC kN3M G=C g h LMN2 RKC LRIC ONkk 1 ON53 G<C 2RIC ONj5 G=C g h
4Nk RKC LRIC ON2k 1 ONL3 G<C LRIC ONL2 1 jN4k G<C 5RIC jNi5 G=C g h LjN2 RKC LRIC jNk4 1 jNk2 G<C
2RIC jN54 G@C jRIC jN53 G@C jRIC jN25 G@C LRIC 2Ni3 1 2NkL G<C ORIC 2NM5 1 LN4k G<C 2RIC LN4M 1 LNi2
G<C 2RIC LNM3 G@C jRIC LNM5 G@C jRIC LNM2 G@C jRIC MN4O G@C jRIN
12341
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- - - %!" #$%$ %$0 !& - 1 1 $0 )/ + ,
!)*).!2 2 $3,4,4 5 ( )/ , ( %! !/ + / . /* + - + %!$0$ %!" #$%$
7 , & (%$()/ , , $0) 6 , %))*) 0) 2)/ ) 6+ 4
89:;<=;>?@:;AB C D E+ @9> -4 FG HIG8J =KL MMNMO7 PFQRS QO MR TFU HN44 FRLD F;:V@9WX1
YZ[\]\^_`a\1 3O2b H=D MRJD 3OMc H>D d e fON RLD MRJD 3OM4 H>D d e 2Oc RLD MRJD cOgf H>>D d e 3OgD
2OM RLD MRJD cO7b H:D d e 7fOc RLD MRJD cON7 H>D d e 3O2 RLD 2RJD cOb2 H>D d e cOf RLD 2RJD cO22 H>D
d e 3OM RLD 2RJD cOMb H>D d e fO3 RLD MRJD gOfN H>D d e 2Oc RLD MRJD gO34 H>D d e M4O2 RLD MRJD
M4 gOcM 1 gOgb H=D MRJD 7O4c 1 7O4M H=D MRJD NOc2 1 NOg3 H=D MRJD NOgN 1 NO7N H=D 2RJD NO72 1 NONf
H=D MRJD NONc 1 NONM H=D MRJD NOb4 H>D d e M4O4 RLD MRJD NO24 1 NO43 H=D 2RJD bOfN H>D d e MbOM
RLD MRJD bOcf H>D d e MMO4 RLD MRJD bOc2 H>D d e MMOc RLD MRJD bOgf HAD bRJD bOgg HAD bRJD 2Ofb 1
2O32 H=D bRJD 2O3M 1 2Ocb H=D MRJD 2Obb HAD 2RJD MOMg HAD bRJD MOM7 HAD bRJD MOMM HAD bRJD MO42 HAD
bRJO
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89:;<=;>?@:;AB C D E+ @9> +i4 FG HIG8J =KL MMNMOg PFQRS QO MR TFU HN44 FRLD F;:V@9WX1
YZ[\]\^_`j\kYYl\m\n\`_`l\o_^\pql\rp[l\^_rs\kYl\m\n\a_Z\pql\rp[l\^_ro\kYl\m\n\`_s\pql\rp[l\s_sZ\1
12341
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8 364 2 564 8 6 4 76 8 263 4 763 8 6 4
7654 1 7674 89 4 6 8 4 6 1 6 89 4 65 8 36 6 4 67 1 6
89 2 6 4 8 4 6 8 63 4 6 8 4 6 4 643 1 64 89 2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762455348P | 2017-02-06 | 2017-02-06 | |
| US62/455,348 | 2017-02-06 | ||
| PCT/US2018/016893 WO2018145021A1 (en) | 2017-02-06 | 2018-02-05 | Atazanavir (atv) analogues for treating hiv infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NZ755929A NZ755929A (en) | 2021-08-27 |
| NZ755929B2 true NZ755929B2 (en) | 2021-11-30 |
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