NZ750708B2 - Inorganic ion detection system and methods - Google Patents

Inorganic ion detection system and methods

Info

Publication number
NZ750708B2
NZ750708B2 NZ750708A NZ75070817A NZ750708B2 NZ 750708 B2 NZ750708 B2 NZ 750708B2 NZ 750708 A NZ750708 A NZ 750708A NZ 75070817 A NZ75070817 A NZ 75070817A NZ 750708 B2 NZ750708 B2 NZ 750708B2
Authority
NZ
New Zealand
Prior art keywords
cartridge
separation
cationic polymer
polymer
separation channel
Prior art date
Application number
NZ750708A
Other versions
NZ750708A (en
Inventor
Heras Gustavo Blanco
Michael Charles Breadmore
Philip James Charles Zakaria
Original Assignee
University Of Tasmania
Filing date
Publication date
Application filed by University Of Tasmania filed Critical University Of Tasmania
Priority claimed from PCT/AU2017/050861 external-priority patent/WO2018032043A1/en
Publication of NZ750708A publication Critical patent/NZ750708A/en
Publication of NZ750708B2 publication Critical patent/NZ750708B2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D57/00—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
    • B01D57/02—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C by electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/025—Displaying results or values with integrated means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/2833—Collecting samples on a sticky, tacky, adhesive surface
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4055—Concentrating samples by solubility techniques
    • G01N2001/4061—Solvent extraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/4473—Arrangements for investigating the separated zones, e.g. localising zones by electric means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44739—Collecting the separated zones, e.g. blotting to a membrane or punching of gel spots
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44752—Controlling the zeta potential, e.g. by wall coatings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus

Abstract

system for the separation and detection of inorganic anions in a sample, the system comprising: • a separation channel with an inner coating of three or more alternating layers of a cationic polymer (e.g. hexadimethine bromide) and an anionic polymer (e.g. polystyrene sulfonate), wherein the first layer and the final layer are cationic polymer layers; • a detector for detecting inorganic anions that pass through a detection zone of the separation channel; • an injection system for injecting fluids including sample solutions and background electrolyte into an inlet end of the separation channel; wherein the background electrolyte comprises polyethyleneimine. Also described are corresponding methods, separation capillaries and cartridges for use in the system.

Claims (22)

CLAIMS :
1. A residue screening device for the separation and detection of nitrate, perchlorate, azide and chlorate anions in a sample, the device comprising: ? a separation channel with an inner coating of three or more alternating layers of a cationic polymer and an anionic polymer, wherein the first layer and the final layer are cationic polymer layers; ? a detector for detecting nitrate, perchlorate, azide and chlorate anions that pass through a detection zone of the separation channel; ? a background electrolyte reservoir containing a background electrolyte comprising polyethyleneimine; and ? an injection system for injecting fluids including sample solutions and background electrolyte into an inlet end of the separation channel; wherein the cationic polymer forming the cationic polymer layers is not polyethyleneimine.
2. The device of claim 1, wherein the anionic polymer forming the anionic polymer layer is a sulfonated or sulphated polymer or copolymer.
3. The device of claim 1 or claim 2, wherein the cationic polymer forming the cationic polymer layers is a hexadimethrine polymer or a polydiallyldimethylammonium polymer.
4. The device of claim 1 or claim 2, wherein the cationic polymer forming the cationic polymer layers is hexadimethrine bromide.
5. The device of any one of claims 1 to 4, wherein the device comprises a controller for controlling the injection system, flow of fluids through the separation channel, and operation of the detector for the detection of the nitrate, perchlorate, azide and chlorate anions.
6. The device of claim 5, wherein the controller controls a channel coating sequence for application of the alternating layers of cationic polymer and anionic polymer onto the separation channel.
7. The device of any one of claims 1 to 6, wherein the device comprises a computer display providing a visual representation of the presence of explosive residues in the 20243095_1 (GHMatters) P104090.NZ sample.
8. The device of any one of claims 1 to 7, wherein the separation channel has 3, 5 or 7 coating layers.
9. A residue screening device according to any one of claims 1 to 8, the device comprising: ? a receiver shaped to receive a replaceable cartridge that contains a separation channel with an inner coating of three or more alternating layers of a cationic polymer and an anionic polymer, wherein the first layer and the final layer are cationic polymer layers; ? a detector positioned to detect nitrate, perchlorate, azide and chlorate anions that pass through a detection zone of the separation channel when the cartridge containing the separation channel is positioned in the receiver; ? an injection system for injecting fluids including sample solutions and background electrolyte comprising polyethyleneimine into an inlet end of the separation channel contained in the cartridge, when the cartridge is positioned in the receiver; ? a background electrolyte reservoir containing said background electrolyte comprising polyethyleneimine; ? a controller for controlling the injection system, flow of fluids, operation of the detector for the detection of the nitrate, perchlorate, azide and chlorate anions; and ? a computer display providing a visual representation of the presence of explosive residues in the sample.
10. The device of any one of claims 1 to 9, wherein the concentration of polyethyleneimine in the background electrolyte is between about 0.03 and 0.08% by weight.
11. A method for the separation and detection of nitrate, perchlorate, azide and chlorate anions in a sample using electrophoresis, the method comprising a sample processing sequence which comprises: - introducing a sample and a background electrolyte comprising polyethyleneimine into a separation channel coated with alternating layers of a cationic polymer and an anionic polymer, wherein the first layer and the final layer of the separation 20243095_1 (GHMatters) P104090.NZ channel coating are cationic polymer layers, and the cationic polymer forming the cationic polymer layers is not polyethyleneimine; - applying a voltage potential across the separation channel to effect a separation of the nitrate, perchlorate, azide and chlorate anions; and - detecting the presence of the separated nitrate, perchlorate, azide and chlorate anions.
12. The method of claim 11, comprising locating a cartridge comprising the separation channel into a position so as to allow the sample processing sequence to be conducted, prior to conducting the sample processing sequence.
13. The method of claim 11, comprising locating a cartridge comprising the separation channel and a background electrolyte reservoir into a position so as to allow the sample processing sequence to be conducted, prior to conducting the sample processing sequence.
14. The method of claim 12 or claim 13, comprising performing multiple sample processing sequences prior to replacing the cartridge with a replacement cartridge after performing multiple sample processing sequences.
15. The method of claim 14, comprising replacing the cartridge with a replacement cartridge after performing not less than 1000 sample processing sequences with the replaced cartridge.
16. The method of any one of claims 11 to 15, wherein the cationic polymer forming the cationic polymer layer is hexadimethrine bromide, the anionic polymer forming the anionic polymer layer is polystyrene sulfonate.
17. The method of any one of claims 11 to 16, wherein the concentration of polyethyleneimine in the background electrolyte is between about 0.03 and 0.08% by weight.
18. Use of a separation capillary comprising an inner coating of three or more alternating layers of a hexadimethrine polymer and polystyrene sulfonate or a copolymer, salt or derivative thereof, wherein the first layer and the final layer are hexadimethrine polymer layers, in the method of any one of claims 11 to 17 for the separation and detection of nitrate, perchlorate, azide and chlorate anions. 20243095_1 (GHMatters) P104090.NZ
19. A cartridge comprising a separation capillary, wherein the separation capillary comprises an inner coating of three or more alternating layers of a hexadimethrine polymer and polystyrene sulfonate or a copolymer, salt or derivative thereof, wherein the first layer and the final layer are hexadimethrine polymer layers, and wherein the cartridge comprises a background electrolyte reservoir comprising a polyethyleneimine-containing background electrolyte composition, when used in the method of claim 11.
20. The cartridge of claim 19, wherein the concentration of polyethyleneimine in the background electrolyte composition is between about 0.04 and 0.08% by weight.
21. The cartridge of claim 19 or claim 20, wherein the hexadimethrine polymer is hexadimethrine bromide.
22. The cartridge of any one of claims 19 to 21, which is shaped for releasable insertion into a receiver of a device for the separation and detection of nitrate, perchlorate, azide and chlorate anions in a sample. 20243095_1 (GHMatters) P104090.NZ
NZ750708A 2017-08-15 Inorganic ion detection system and methods NZ750708B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2016903232A AU2016903232A0 (en) 2016-08-15 Elution and detection
AU2017902304A AU2017902304A0 (en) 2017-06-16 Inorganic ion detection system and methods
PCT/AU2017/050861 WO2018032043A1 (en) 2016-08-15 2017-08-15 Inorganic ion detection system and methods

Publications (2)

Publication Number Publication Date
NZ750708A NZ750708A (en) 2023-12-22
NZ750708B2 true NZ750708B2 (en) 2024-03-26

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