NZ745725A - Oligonucleotide conjugates - Google Patents
Oligonucleotide conjugatesInfo
- Publication number
- NZ745725A NZ745725A NZ74572513A NZ74572513A NZ745725A NZ 745725 A NZ745725 A NZ 745725A NZ 74572513 A NZ74572513 A NZ 74572513A NZ 74572513 A NZ74572513 A NZ 74572513A NZ 745725 A NZ745725 A NZ 745725A
- Authority
- NZ
- New Zealand
- Prior art keywords
- oligonucleotide conjugates
- totalmer
- mixmer
- cleavable
- oligonucleotides
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to the field of oligonucleotide therapeutics, and in particular to the use of a cleavable, e.g. a phosphodiester region covalently attached to a conjugate and a mixmer or totalmer, a targeting group or blocking group to enhance the properties of the oligonucleotides, for example to improve the therapeutic index.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12192773 | 2012-11-15 | ||
EP13153296 | 2013-01-30 | ||
EP13157237 | 2013-02-28 | ||
EP13174092 | 2013-06-27 | ||
NZ70817113A NZ708171A (en) | 2012-11-15 | 2013-11-14 | Oligonucleotide conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ745725A true NZ745725A (en) | 2019-10-25 |
Family
ID=68318670
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ74178213A NZ741782A (en) | 2012-11-15 | 2013-11-14 | Oligonucleotide conjugates |
NZ74572513A NZ745725A (en) | 2012-11-15 | 2013-11-14 | Oligonucleotide conjugates |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ74178213A NZ741782A (en) | 2012-11-15 | 2013-11-14 | Oligonucleotide conjugates |
Country Status (1)
Country | Link |
---|---|
NZ (2) | NZ741782A (en) |
-
2013
- 2013-11-14 NZ NZ74178213A patent/NZ741782A/en unknown
- 2013-11-14 NZ NZ74572513A patent/NZ745725A/en unknown
Also Published As
Publication number | Publication date |
---|---|
NZ741782A (en) | 2019-10-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY173826A (en) | Oligonucleotide conjugates | |
EP2563366A4 (en) | Uses of phospholipid conjugates of synthetic tlr7 agonists | |
EA032986B1 (en) | Pyrrolobenzodiazepines | |
EA032867B9 (en) | Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates | |
BR112015018161A2 (en) | LNA ANTISENSE OLIGOMER CONJUGATE, PHARMACEUTICAL COMPOSITION AND USE OF AN LNA ANTISENSE OLIGOMER CONJUGATE | |
MX344009B (en) | Amatoxin-conjugates with improved linkages. | |
MX2019009283A (en) | PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF. | |
NZ706853A (en) | Vegf neutralizing prodrugs for the treatment of ocular conditions | |
MX2012000575A (en) | ε-POLYLYSINE CONJUGATES AND USE THEREOF. | |
MX2018013332A (en) | Targeted pyrrolobenzodiazapine conjugates. | |
HK1206268A1 (en) | Non linear multiblock copolymer drug conjugates for the delivery of active agents | |
MX344010B (en) | Amatoxin-conjugates with improved linkers. | |
EA201591178A1 (en) | IMPROVED COMPOSITIONS FOR EXTRACT PASSING FOR TREATING MUSCLE DISTROPHIA | |
EP2910573A4 (en) | Antibody-drug conjugate produced by binding through linker having hydrophilic structure | |
MX2021003858A (en) | Conjugates for treating diseases caused by psma expressing cells. | |
MX2010003299A (en) | Micromirs. | |
MY178680A (en) | Hydrogel prodrugs | |
EP2652134A4 (en) | Galactose cluster-pharmacokinetic modulator targeting moiety for sirna | |
EP2723393A4 (en) | Extracellular targeted drug conjugates | |
EP2796150A4 (en) | Novel oligonucleotide conjugates and use thereof | |
PH12015500664A1 (en) | Pharmaceutical combinations comprising dual angiopoietin-2/dll4 binders and anti-vegf-r agents | |
WO2013120038A3 (en) | Morpholino targeting dux4 for treating fshd | |
EP2683737A4 (en) | Extracellular targeted drug conjugates | |
EP2766051A4 (en) | Porphyrin-phospholipid conjugate microbubbles and their use as contrast agents. | |
EP2663338A4 (en) | Oligosaccharide conjugates for targeting bacteria and uses related thereto |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PSEA | Patent sealed | ||
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 14 NOV 2021 BY THOMSON REUTERS Effective date: 20200926 |
|
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 14 NOV 2022 BY THOMSON REUTERS Effective date: 20211002 |
|
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 14 NOV 2023 BY THOMSON REUTERS Effective date: 20221003 |