NZ741335A - New bicyclic dihydroisoquinoline-1-one derivatives - Google Patents
New bicyclic dihydroisoquinoline-1-one derivativesInfo
- Publication number
- NZ741335A NZ741335A NZ74133512A NZ74133512A NZ741335A NZ 741335 A NZ741335 A NZ 741335A NZ 74133512 A NZ74133512 A NZ 74133512A NZ 74133512 A NZ74133512 A NZ 74133512A NZ 741335 A NZ741335 A NZ 741335A
- Authority
- NZ
- New Zealand
- Prior art keywords
- dihydroisoquinoline
- compounds
- derivatives
- pyridin
- dihydro
- Prior art date
Links
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- OIMHVAZQSMNNEJ-UHFFFAOYSA-N 5-chloro-3,3-dimethyl-2-[5-[(1-methylpyrazol-4-yl)methyl]pyridin-3-yl]isoindol-1-one Chemical compound C1=NN(C)C=C1CC1=CN=CC(N2C(C3=CC(Cl)=CC=C3C2=O)(C)C)=C1 OIMHVAZQSMNNEJ-UHFFFAOYSA-N 0.000 abstract 1
- FBEWBUQUJHVHSR-UHFFFAOYSA-N 6-chloro-2-pyridin-3-yl-3,4-dihydroisoquinolin-1-one Chemical compound C1CC2=CC(Cl)=CC=C2C(=O)N1C1=CC=CN=C1 FBEWBUQUJHVHSR-UHFFFAOYSA-N 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 208000016998 Conn syndrome Diseases 0.000 abstract 1
- 208000014311 Cushing syndrome Diseases 0.000 abstract 1
- 108010009911 Cytochrome P-450 CYP11B2 Proteins 0.000 abstract 1
- 102100024329 Cytochrome P450 11B2, mitochondrial Human genes 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000020832 chronic kidney disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 208000013846 primary aldosteronism Diseases 0.000 abstract 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Provided are dihydroisoquinoline-1-one derivative compounds of formula (I), wherein the variables are as defined in the specification. Examples of the compounds include 6-Chloro-2-pyridin-3-yl-3,4-dihydro-2H-isoquinolin-1-one and 5-Chloro-3,3-dimethyl-2-[5-(1-methyl-1H-pyrazol-4-ylmethyl)-pyridin-3-yl]-2,3-dihydro-isoindol-1-one. The compounds are inhibitors of aldosterone synthase. The compounds may be useful in the treatment of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011083229 | 2011-11-30 | ||
| NZ72424612 | 2012-11-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ741335A true NZ741335A (en) | 2019-10-25 |
Family
ID=68318676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ74133512A NZ741335A (en) | 2011-11-30 | 2012-11-27 | New bicyclic dihydroisoquinoline-1-one derivatives |
Country Status (1)
| Country | Link |
|---|---|
| NZ (1) | NZ741335A (en) |
-
2012
- 2012-11-27 NZ NZ74133512A patent/NZ741335A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 6 YEARS UNTIL 27 NOV 2022 BY AJ PARK Effective date: 20200220 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 NOV 2023 BY THOMSON REUTERS Effective date: 20221003 |
|
| LAPS | Patent lapsed |