NZ735678B2 - Pump cap for a pharmaceutical container, insert for a pump cap for a pharmaceutical container, pharmaceutical container with the pump cap, and computer program product - Google Patents
Pump cap for a pharmaceutical container, insert for a pump cap for a pharmaceutical container, pharmaceutical container with the pump cap, and computer program product Download PDFInfo
- Publication number
- NZ735678B2 NZ735678B2 NZ735678A NZ73567816A NZ735678B2 NZ 735678 B2 NZ735678 B2 NZ 735678B2 NZ 735678 A NZ735678 A NZ 735678A NZ 73567816 A NZ73567816 A NZ 73567816A NZ 735678 B2 NZ735678 B2 NZ 735678B2
- Authority
- NZ
- New Zealand
- Prior art keywords
- pump cap
- personal digital
- digital assistant
- pharmaceutical container
- electronic unit
- Prior art date
Links
- 238000004590 computer program Methods 0.000 title claims description 64
- 230000004913 activation Effects 0.000 claims abstract description 43
- 239000003814 drug Substances 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims description 48
- 230000001702 transmitter Effects 0.000 claims description 34
- 229920003023 plastic Polymers 0.000 claims description 18
- 239000004033 plastic Substances 0.000 claims description 18
- 239000002775 capsule Substances 0.000 claims description 14
- 229910052751 metal Inorganic materials 0.000 claims description 13
- 239000002184 metal Substances 0.000 claims description 13
- 239000011888 foil Substances 0.000 claims description 10
- 230000000875 corresponding Effects 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 229940097496 Nasal Spray Drugs 0.000 claims description 7
- 239000007922 nasal spray Substances 0.000 claims description 7
- 239000004698 Polyethylene (PE) Substances 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 6
- 229920000573 polyethylene Polymers 0.000 claims description 6
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 6
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- WMWTYOKRWGGJOA-CENSZEJFSA-N Fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims description 5
- 229960000289 fluticasone propionate Drugs 0.000 claims description 5
- 229920001665 Poly-4-vinylphenol Polymers 0.000 claims description 4
- -1 Polyethylene terephthalate Polymers 0.000 claims description 4
- 229920001721 Polyimide Polymers 0.000 claims description 4
- 239000004642 Polyimide Substances 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 230000001419 dependent Effects 0.000 claims description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 4
- 229920002037 poly(vinyl butyral) polymer Polymers 0.000 claims description 4
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 4
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 4
- 239000004800 polyvinyl chloride Substances 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- GEVMVZWOOIIINI-KTIJLCEXSA-N 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one;[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propano Chemical compound Cl.C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O GEVMVZWOOIIINI-KTIJLCEXSA-N 0.000 claims description 3
- 229940075416 Dymista Drugs 0.000 claims description 3
- 230000003213 activating Effects 0.000 claims description 3
- 238000011156 evaluation Methods 0.000 claims description 3
- 229920000122 Acrylonitrile butadiene styrene Polymers 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims description 2
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 claims description 2
- 229960004574 azelastine Drugs 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 239000004417 polycarbonate Substances 0.000 claims description 2
- 229920000515 polycarbonate Polymers 0.000 claims description 2
- 239000011112 polyethylene naphthalate Substances 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 229920005989 resin Polymers 0.000 claims description 2
- 239000011347 resin Substances 0.000 claims description 2
- 229920002554 vinyl polymer Polymers 0.000 claims description 2
- 230000000007 visual effect Effects 0.000 claims description 2
- MBUVEWMHONZEQD-UHFFFAOYSA-N Azeptin Chemical compound C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1 MBUVEWMHONZEQD-UHFFFAOYSA-N 0.000 claims 1
- 229920002994 synthetic fiber Polymers 0.000 claims 1
- 239000010410 layer Substances 0.000 description 6
- 229940079593 drugs Drugs 0.000 description 5
- YEJAJYAHJQIWNU-UHFFFAOYSA-N azelastine hydrochloride Chemical compound Cl.C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1 YEJAJYAHJQIWNU-UHFFFAOYSA-N 0.000 description 4
- 238000005086 pumping Methods 0.000 description 4
- 229960004335 Azelastine hydrochloride Drugs 0.000 description 3
- 229940071648 Metered Dose Inhaler Drugs 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminum Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 239000003990 capacitor Substances 0.000 description 3
- 238000004146 energy storage Methods 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000002985 plastic film Substances 0.000 description 3
- 238000004513 sizing Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- WRMNZCZEMHIOCP-UHFFFAOYSA-N Phenethyl alcohol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000000670 limiting Effects 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 239000006200 vaporizer Substances 0.000 description 2
- 208000006673 Asthma Diseases 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229950008138 Carmellose Drugs 0.000 description 1
- FYGDTMLNYKFZSV-MRCIVHHJSA-N Dextrin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](CO)OC(O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-MRCIVHHJSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229940067107 Phenylethyl Alcohol Drugs 0.000 description 1
- 229940068968 Polysorbate 80 Drugs 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 230000002596 correlated Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 239000002365 multiple layer Substances 0.000 description 1
- 230000000149 penetrating Effects 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/30—Compliance analysis for taking medication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2205/00—General identification or selection means
- A61J2205/60—General identification or selection means using magnetic or electronic identifications, e.g. chips, RFID, electronic tags
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
- A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
- A61J7/0427—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3546—Range
- A61M2205/3561—Range local, e.g. within room or hospital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
- A61M2205/3592—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using telemetric means, e.g. radio or optical transmission
-
- B05B11/30—
-
- B05B11/308—
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B12/00—Arrangements for controlling delivery; Arrangements for controlling the spray area
- B05B12/004—Arrangements for controlling delivery; Arrangements for controlling the spray area comprising sensors for monitoring the delivery, e.g. by displaying the sensed value or generating an alarm
- B05B12/006—Pressure or flow rate sensors
- B05B12/008—Pressure or flow rate sensors integrated in or attached to a discharge apparatus, e.g. a spray gun
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B12/00—Arrangements for controlling delivery; Arrangements for controlling the spray area
- B05B12/02—Arrangements for controlling delivery; Arrangements for controlling the spray area for controlling time, or sequence, of delivery
-
- G—PHYSICS
- G08—SIGNALLING
- G08B—SIGNALLING OR CALLING SYSTEMS; ORDER TELEGRAPHS; ALARM SYSTEMS
- G08B21/00—Alarms responsive to a single specified undesired or abnormal condition and not otherwise provided for
- G08B21/18—Status alarms
- G08B21/182—Level alarms, e.g. alarms responsive to variables exceeding a threshold
-
- G—PHYSICS
- G08—SIGNALLING
- G08B—SIGNALLING OR CALLING SYSTEMS; ORDER TELEGRAPHS; ALARM SYSTEMS
- G08B21/00—Alarms responsive to a single specified undesired or abnormal condition and not otherwise provided for
- G08B21/18—Status alarms
- G08B21/24—Reminder alarms, e.g. anti-loss alarms
-
- G—PHYSICS
- G08—SIGNALLING
- G08B—SIGNALLING OR CALLING SYSTEMS; ORDER TELEGRAPHS; ALARM SYSTEMS
- G08B25/00—Alarm systems in which the location of the alarm condition is signalled to a central station, e.g. fire or police telegraphic systems
- G08B25/009—Signalling of the alarm condition to a substation whose identity is signalled to a central station, e.g. relaying alarm signals in order to extend communication range
-
- G—PHYSICS
- G08—SIGNALLING
- G08B—SIGNALLING OR CALLING SYSTEMS; ORDER TELEGRAPHS; ALARM SYSTEMS
- G08B25/00—Alarm systems in which the location of the alarm condition is signalled to a central station, e.g. fire or police telegraphic systems
- G08B25/01—Alarm systems in which the location of the alarm condition is signalled to a central station, e.g. fire or police telegraphic systems characterised by the transmission medium
- G08B25/10—Alarm systems in which the location of the alarm condition is signalled to a central station, e.g. fire or police telegraphic systems characterised by the transmission medium using wireless transmission systems
Abstract
The present invention relates to a pump cap for a pharmaceutical container, and/or a pump cap inlay for a pharmaceutical container. In particular, the present invention relates to a pump cap, and a pump cap inlay, for registering the activation of the pump cap by a user and wirelessly transmitting a signal indicating activation of the pump cap to an electronic device in the form of a personal digital assistant (PDA). The present invention may assist in providing an overview of the activation of the pump cap to a patient or a doctor to assist in monitoring administration of pharmaceuticals. a signal indicating activation of the pump cap to an electronic device in the form of a personal digital assistant (PDA). The present invention may assist in providing an overview of the activation of the pump cap to a patient or a doctor to assist in monitoring administration of pharmaceuticals.
Description
Pump cap for a pharmaceutical container, insert for a pump cap for a pharmaceutical
container, pharmaceutical container with the pump cap, and computer program product.
Specification
Technical field, prior art, technological background
The following is a description of a pump cap for a pharmaceutical container, an inlay for a pump
cap for a pharmaceutical container with a pump cap and a computer program product that serves
the pump cap jointly with an electronic unit.
Examples of administered, nasally and sublingually, controlled substances from a container are
the well known, various and costly aerosol metering valves and spray pumps by Aptar Pharma,
for example (www.aptar.com).
Recording the discharge processes of such pharmaceutical dispensers can help count the number
of discharge processes. The patient or the doctor can thus be provided with an overview of the
discharge processes that were carried out. In this regard, DE 10 2010 042 007 A1 and DE 10
2008 064 559 A1 are also referred to as technological background.
From DE 10 2014 204 939 B3, a dispenser in the shape of an MDI (Metered Dose Inhaler) for
discharging a pharmaceutical medium is popular. This dispenser has a sensor to record a
discharge process and an electronic processing circuit to record and further process one of the
signals emitted from the sensor. The sensor is part of a sensor unit, which has a radio transmitter
to produce a radio signal and the processing circuit has a radio receiver adapted to receive radio
signals produced from the radio transmitter.
US 2015/061867 A1 relates to devices and methods for the electronic surveillance and recording
of the emission of particularly pharmaceutical substances through various donating devices,
including the wireless transfer of the recorded data to an external electronic device.
A1 discloses a vaporizer for donating pharmaceutical substances, which is
appropriate and determined to dose a respectively administered medication by an external
electronic device.
US 8,8071,131 B1 discloses a device and a method for surveilling the use of a vaporizer by
asthma patients, including a computer program product, which is determined for the use on smart
phones or personal digital assistants (PDA).
Two electronic components are thus intended for this dis penser, which are integrated in a joint
dispenser but are not galvanically coupled to each other. Instead, both electronic components, the
sensor unit and the processing circuit are connected via a radio interface. This processing circuit
has an energy source (battery or accumulator) that stores the radio receiver and display device in
a specific location in a dispenser and, if applicable, a storage device to save the discharge
processes, taking into consideration the time of the discharge process. The sensor unit has a
sensor, a radio transmitter and, if applicable, an energy source (battery and accumulator) for
operating the radio transmitter. Instead of the energy source, a converter is intended to convert
mechanical energy to electrical energy, which is identical with the sensor. The user thus uses it to
convert the energy created by the discharge process into electrical energy for the radio
transmitter. A piezoelectric generator serves as a converter.
Underlying problem
This arrangement has a string of disadvantages, of which only a few are mentioned here. It is a
separate, receiving unit of a pharmaceutical container to be additionally purchased by the user
(the patient). It makes the medication container to be carried by the patient bigger. Its operation
is also conceptually very expensive. On one hand, the signal and energy producing piezoelectric
generator is expensive. On the other hand, the arrangement of batteries and an display in the
processing circuit located in the dispenser are also to be disposed of after the life span of the
arrangement.
Solution to the problem
In order to at least partially solve the previously mentioned problems, a pump cap for a
pharmaceutical container, an inlay for a pump cap for a pharmaceutical container with a pump
cap and a computer program product for a personal digital assistant is suggested.
There is an electronic unit in the pump cap. This electronic unit is adapted, on one hand, to
record the activation of a pump cap by a user to release the content of the container and, on the
other hand, to release the reporting signals of the activations of the pump cap in a wireless
manner, in order to allow the required operational energy to be led from outside in a wireless
manner for the record of activations and release of signals.
The operational energy of the electronic unit will be transmitted from an electronic
unit, independent of the pump cap, in the form of a so-called personal digital assistant (PDA),
such as a mobile or cordless phone, a so-called smart phone, a so-called smart watch, a tablet
computer, a notebook or something similar; the electronic unit is adapted to receive the
operational energy of the personal digital assistant.
Advantages, designs
The pharmaceutical container with this kind of adapted pump cover is essentially less costly in
production and thus also in disposal. The electronic unit with a pharmaceutical container
comprising approximately 100 to 200 medications, independent of the pump cap, has a longer
life and operational cycle than a pharmaceutical container with a pump cap. The costly
disposable part of the discharge unit of DE 10 2014 204 939 B3 with batteries and an display is
thus omitted. What’s more, it is, nevertheless, common for a user these days to move around
with such a person digital assistant (PDA) at all times. Likewise, a patient who has to administer
nasal and sublingual controlled (pharmaceutical) substances carries this pharmaceutical container
about as a rule. As long as the user avoids the solution suggested here in terms of carrying
unnecessary electronic appliances i.e. he passes on the pump cap on the pharmaceutical container
on the processing circuits with batteries and accumulators suggested here, the radio receiver and
the MDI display device of DE 10 2014 204 939 B3. Furthermore, the expensive cost-intensive
piezoelectrical generator is omitted.
The electronic appliance, namely the personal digital assistant, has, on one hand, corresponding
structural components in the form of one or several antennae or other emitters such as the
associated control electronics and a processor with storage and input/output elements (touch-
sensitive display panels). A computer program product is suggested for the processor of the
personal digital assistant (a so-called app), which allows the control electronics of the antenna to
release operational energy for the electronic unit of the pump cover in order to receive the signals
released from the electronic unit in a wireless manner and, after their processing, to have the
processor display the pump cap activations on the display of the electronic appliance.
The electronic unit of the pump cap is a transmitter, for example in the form of a RFID- Module
(RFID = Radio Frequency Identification) and essentially has a chip module comprising an
antenna designed as a coil or dipole. This chip module enables the contactless, automated
registration and/or retrieval of data in / out of the chip of a transmitter. Such a transmitter
comprises, for example, a coil-shaped transmitter antenna next to the chip, which enables data
access. A pump cap personalization, explained in detail, is part of the registered data, more
precisely relating to the pharmaceutical container, with regards to “pairing” with the computer
program product of the personal digital assistant. The signals reported by the pump cap
activations are part of the retrieved data.
The transmitter, thus the antenna and chip module, is integrated in the pump cap and receives its
operational energy from the personal digital assistant (PDA) only if the user activates the
corresponding computer program product on the personal digital assistant, or, permanently, as
long as the pump cap on the pharmaceutical container is sufficiently close to the personal digital
assistant and radiates energy via its corresponding antenna(e).
In a variant, the transmitter is adapted to transmit data via Near Field Communication (= NFC)
via radio and within a short distance of approximately 10cm to 20cm. Details in this regard are
also explained in ISO / IEC 14443 A and B or in ISO / IEC 15693. Data for the NFC
Communication is thus transmitted at a 13.56 MHz range. In this regard, active and passive NFC
transformers can be used. Active NFC transmitters are able to initiate and communicate
connections. Passive NFC transmitters are not able to build connections independently. They
need an active partner, in this case the PDA, to test the data.
Active transmitters need a source of energy whilst the passive transmitter can manage without a
source of energy. In order to state their information via the pumping operation(s), passive
transmitters make use of the energy transferred from active readers. Energy is transferred to the
transmitter via the active reader, in order to transmit information about the pumping operation(s)
within a short distance of around 10 cm to 20 cm. In a variant, the operation energy storage of
the transmitter is meant to be assigned, for example, in the form of a capacitor.
Since a diversity of smart phones (Apple 6, Android, BlackBerry, Windows, etc) is being
planned or already exists, those equipped with NFC functionality (according to NFC-Standard
ISO / IEC 14443 A and B or ISO / IEC 15693), namely coils, control electronics, appropriate
NFC-control software (NFC protocol stack) in the processor-operational system of the Smart
phone, the inlay / electronic unit of the pump cap in different smart phones or other personal
digital assistants PDA are supplied with operational energy to respond and retrieve. Such a
personal digital assistant is used for the collaboration of the pump cap described here and/or the
inlay described below.
Instead of a Near-Field Communication, (energy and) data transmission can also occur via
Bluetooth Standard, Wibree Standard, ANT+-Standard or Zigbee Standard.
In a variant, the electronic unit of a pump cap is equipped with a sensor comprising a switch
adapted to record a discharge process. This switch can be built in a particularly simple form
through two electrical contacts that are electrically bridged to the opening of the pharmaceutical
container via a metallic , for example aluminum, capsule if the user presses down the pump
cover to cause a discharge process. If the cap of the pharmaceutical container is designed without
a metal capsule, then the switch simply has an opening or closing switch. Aside from this switch
sensor, a capacitive, magnetic or other form of recording can be used to ensure that the electronic
unit is capable of releasing an appropriate signal.
In an additional variant, an inlay in a pharmaceutical container is suggested, wherein the
electronic unit is a transmitter. The transmitter comprises essentially a chip module comprising
an antenna designed as a coil or dipole for the contactless, automated registration and/or retrieval
of data in and out of the chip, wherein the registered data comprises a personalized identifier for
pairing the electronic unit with a computer program product in the personal digital assistant
(PDA) and/or the retrieved data comprise the signals reported by the activation of the pump
covers.
The inlay comprises plastic wrap, whose outside diameter is smaller than the inside diameter of
the pump cap. The inlay is shaped in a way that it is inserted and, if applicable, stuck into the
pump cap to ensure that it is accommodated between the opening of the pharmaceutical container
and one located at the pump operation toward the fixed pharmaceutical container wall and the
pump cap. The plastic wrap of the inlay has an opening passage for a drug discharge socket. The
plastic wrap carries the chip module of the transmitter and its antenna, which is equipped as a
planar ring coil or dipole. In this variant, the electronic unit is also equipped with a sensor with a
switch adapted for recording the discharge process. This switch can be built in a particularly
simple form through two electrical contacts that are electrically bridged to the opening of the
pharmaceutical container via a metallic, for example aluminum, capsule if the user presses down
the pump cover to cause a discharge process. If the opening of the pharmaceutical container is
designed without a metal capsule, then the switch simply has an opening or closing switch.
Otherwise, capacitive, magnetic or other types of sensor systems are appropriate to record one or
several occurring discharge processes. The discharge process is then transmitted via the
transmitter to the personal digital assistant.
Foil material for the inlay can be wood-free paper, coating paper or paper stuffed with resin,
synthetic and/or plastic foil from plastic material such as Polyethylene (PE), Polyvinyl chloride
(PVC), Polyvinyl chloride-Acetate-Copolymer, Polyethylene terephthalate (PET) or
Polyethylene terephthalate glycol-modified (PETG), Polyethylene naphthalate (PEN),
Acrylonitrile-Butadiene-Styrene-Copolymers (ABS), Polyvinyl butyral (PVB), Polymethyl-
methacrylate (PMMA), Polyimide (PI), Polyvinyl alcohol (PVA), Polystyrene (PS), Polyvinyl
phenol (PVP), Polyethylene (PE), Polypropylene (PP), Polycarbonate (PC) or their foil
derivatives with a thickness of at least 75 µm or more. One or multiple layers of the support
structure can be produced from this foil material in which one or several multi-layer spiral or
cylindrical coil can be produced as antenna coil for Near-Field Communication. Furthermore, a
capacitor can be included to store the operational energy received via the antenna coil in such
single or multi-layer support structures.
A shape (diameter and height) of a 1 Euro coin is thus produced for the inlay, for example, with
a central passage opening (a few millimeters of the diameter or the lateral dimension) for the
drug discharge socket of the pharmaceutical container.
This inlay is particularly advantageous provided it can be used in the readily conceived
container from pump caps and pharmaceutical containers prior to final assembly without any
modification carried out on the pump cap or the pharmaceutical container. Through the small
construction height, which is derived from the thickness of the foil materials and chips as well as
the sensor arrangement, the actuation path of the pump cap also does not undergo any practical
change to ensure that the discharge volume of the medication during the activation of the pump
cap also does not vary with the figure in the inlay located in the pump cap.
In one aspect an assembly is provided, comprising (i) a pharmaceutical container comprising a
nasal spray, for example in the form of a solution or suspension, preferably Dymista® nasal
spray (an azelastine HCl/Fluticasone propionate combination), (ii) a pump cap connected to a
drug discharge socket of the pharmaceutical container, and (iii) an electronic unit, which is either
accepted in an insert provided between the pharmaceutical container and the pump cap, or
directly in said pump cap. Here, the pump cap can be realized with the electronic unit and/or the
insert provided between the pharmaceutical container and the pump cap in the variants described
above.
In another aspect, a computer program product is provided for the personal digital assistant PDA,
which is adapted and programmed so that an electronic unit is supplied in an inlay or, directly in
a pump cap according to one of the previous claims by an appropriate control of the personal
digital assistant PDA with operating energy and discharge processes from the pharmaceutical
container is detected, comprising a preparation mode in order to implement a pairing of a
respective electronic unit in an inlay in the pump cap or directly in a pump cap with a personal
digital assistant, a wake-up mode in order to activate the electronic unit in the inlay and/or in the
pump cap, a receiving mode in order to wait for the user to activate the pump cap so that the
electronic unit transmits signals which reflect the discharge processes from the pharmaceutical
container by activating the pump cap, an evaluation mode in order to measure the time elapsed
between successive activations of the pump cap and to categorize different events based on the
time elapsed.
Additional details are also defined in the dependent claims.
Brief description of the drawings
Additional goals, features, advantages, and potential applications are discernible from the
following description of design examples with reference to the corresponding drawings, which
shall not be considered limiting in any way. Here, all features described and/or illustrated by
images show per se or in arbitrary combinations thereof the objective disclosed here, regardless
of their grouping in the claims or their reference. The dimensions and proportions of the
components shown in the figures are not necessarily true to scale here; in order to implement a
design; they may deviate from the illustration.
Fig. 1 shows a variant of the pump cap in a schematic, lateral cross-section in cooperation with a
computer program executed on a personal digital assistant PDA,
Fig. 1a shows a variant of an electronic unit for the pump cap with a transmitter and an antenna
12a designed as a coil in a schematic illustration,
Fig. 2 shows another variant of a pump cap in a schematic lateral cross-section in cooperation
with a computer program product executed on a personal digital assistant,
Fig. 2a shows a variant of an electronic unit for the pump cap with a transmitter and an antenna
designed as a coil in a schematic top view,
Fig. 3 shows another variant of a pump cap in a schematic lateral cross-section in cooperation
with a computer program product executed on a personal digital assistant,
Fig. 4 shows the computer program product in cooperation with an electronic unit in the pump
cap or the use with the personal digital assistant, on which the computer program product is
executed.
Detailed description of the drawings
Fig. 1 shows a first design of a pump cap 10 made from plastic for a pharmaceutical container
18. This pump cap 10 is designed as an attachment for the pharmaceutical container 18. For this
purpose, the pump cap 10 comprises an applicator socket 10a, which conically tapers towards it
free end. The applicator socket 10a extends away from a seat 10c showing a constant radius arch,
which is designed to accept the pharmaceutical container 18. This pharmaceutical container 18
comprises a fluid reservoir, not shown in greater detail, a metal, for example aluminum, capsule
18a, closing the neck of the pharmaceutical container 18, and an outlet socket 18b. The metal
capsule 18a and the outlet socket 18b can be displaced in reference to each other. Here, the
pharmaceutical container 18 is designed such that by pushing down the seat 10c showing a
constant radius arch, the pump cap 10 is pressed in the direction towards the metal capsule 18a of
the outlet socket 18b into the neck of the pharmaceutical container 18, and here a defined volume
of the pharmaceutical medium, previously located in the liquid reservoir of the pharmaceutical
container 18, is discharged through the outlet socket 24.
The outlet socket 24 is accepted in an outlet channel 10b allocated to the applicator socket 10a.
The seat 10c with a constant radius arch shows a cover disk and a tubular section. The tubular
section is open at one (lower) end and encompasses the neck and perhaps partially the upper
section of the pharmaceutical container 18. The cover disk of the seat 10c with a constant radius
arch closes the tubular section at its other (upper) end and is pressed for discharging the
pharmaceutical medium in the direction towards the metal capsule 18a of the pharmaceutical
container 18.
An electronic unit 12 is allocated to the pump cap 10. Said cap in turn is adapted to detect any
activation of the pump cap 10 by the user in reference to the pharmaceutical container 18, in
order to discharge the content of the container. Furthermore, the electronic unit 12 is adapted to
wirelessly transmit signals reflecting such activations of the pump cap 10. Finally, the electronic
unit 12 is adapted to be wirelessly supplied with operating energy from the outside using an
electronic device, here a personal digital assistant PDA for (i) detecting one or more actuations
of the pump cap 10 by a user and for (ii) wirelessly transmitting signals regarding one or more
activation(s) of the pump cap 10.
As also illustrated in Fig. 1a, the electronic unit 12 includes a transmitter, which essentially
comprises a chip module and an antenna 12a designed as a coil or as a dipole. The electronic unit
12 is adapted for the wireless, automatic registering and/or retrieval of the data in/out of the chip.
The data to be entered includes, for example, a personal identification to pair the electronic unit
12 with a computer program product on the personal digital assistant PDA. This way it is
ensured that a pharmaceutical container 18, more precisely its pump cap / its electronic unit 12,
communicates exclusively the pump processes to be counted to the computer program product
on the personal digital assistant of a user of the pharmaceutical container 18. The data to be read
from the electronic unit 12 includes the signals reflecting the activation of the pump cap 10. This
data telegram to be transmitted can additionally include the personal identifications written
during the pairing of the computer program product on the personal digital assistant PDA of the
respective user in the electronic unit 12.
Via the antenna 12a, designed in Fig. 1a as a coil, the electromagnetic energy received by the
antenna 12a, transmitted by the personal digital assistant PDA, can be collected in the electronic
unit 12 via an energy generation circuit and saved as electric energy in the operating energy
storage unit 12c here realized as a capacitor. This way, the electric energy is available for
subsequent energy supply of the chip module when transmitting the signals reflecting the
actuation of the pump cap 10 (perhaps in the data telegram including the personalized
identification).
In the variant of Fig. 1 the electronic unit 12 of the transmitter is integrated in the pump cap. The
transmitter is adapted to only receive operating energy from the personal digital assistant when
the user of the respective computer program product is activated on the personal digital assistant
PDA. In this case, the PDA emits the energy via an appropriate antenna. Alternatively, the
transmitter and/or its electronic unit 12 are adapted to permanently receive operating energy
from the personal digital assistant PDA as long as the pump cap 10 is located on the
pharmaceutical container 18 in a sufficient spatial proximity of the personal digital assistant
PDA and this PDA emits via appropriate antenna(e) energy to the antenna 12a of the electronic
unit 12.
The electronic unit 12 is equipped with a sensor 12b, which shows in one variant a switch
adapted for recording an output process. This switch can be formed in a particularly simple form
by two electric contacts, which are electrically bridged by a metal capsule 18a to close the
pharmaceutical container 18 when the user pushes the pump cap 10 down to such an extent that a
discharge process occurs. If the closure of the pharmaceutical container 18 was to be performed
without any metal capsule 18a, for example designed by an electrically non-conductive plastic,
the sensor 12b may represent a switch designed as a simple opening or closing switch sensor.
Instead of this switch, here a capacitive, magnetic, or other sensor 12b may also be provided for
detecting the pumping process so that the electronic unit 12 can emit a signal to the personal
digital assistant PDA, respectively representing the discharge process.
For the electronic unit 12, such NFC-components of the companies NXP (www.nxp.com) or
AMS (www.ams.com) may be used for example, respectively comprising a signal input, in order
to record and process sensor signals, and to allow transmitting them via the antenna 12a to the
personal digital assistant PDA.
In the variant illustrated in Fig. 1, the antenna 12a is embedded in the plastic material of the
applicator socket 10a of the pump cap 10. Here, the coil antenna 12a designed as a loop shows
several windings, which taper following the cone of the applicator socket 10a. In other variants,
not shown here, the coil antenna 12a may also be accepted in the seat 10c with a constant radius
arch, for example in the cover disk of the seat 10c with a constant radius arch or its tubular
section.
In the variant shown in Figs. 2 and 3, the electronic unit 12 is not embedded in the plastic
material of the pump cap 10. Rather, here the electronic unit 12 is a part of a separate insert in
the form of an inlay for the pump cap 10 of a pharmaceutical container 18 that can be produced
independently from the pump cap 10.
The tubular section of the pump cap 10 is open at one (lower) end and encompasses the neck and
perhaps partially the upper section of the pharmaceutical container 18. The cover disk of the seat
10c with a constant radius arch closes the tubular section at its other (upper) end and is pressed in
the direction towards the metal cap 18a of the pharmaceutical container 18 in order to discharge
the pharmaceutical medium. The inlay is located at the interior wall of the cover disk of the seat
10c with a constant radius arch, for example adhered or fastened by way of spot welding. This
inlay also shown in Fig. 2a shows a circular disk-shaped form with the diametric dimensions of
approximately a 1-Euro coin, here with a round, central penetrating opening (showing a few
millimeters in diameter or lateral dimension) for the drug discharge socket 18c of the
pharmaceutical container 18.
The inlay carries the electronic unit 12 at the side (in Fig. 2 at the bottom) facing the
pharmaceutical container 18. Similar to the variant of Fig. 1, it is equipped with a sensor 12b,
which in one variant shows a switch adapted to detect a discharge process. This switch can be
formed in a particularly simple design by two electric contact sites, which are then electrically
bridged by a metal capsule 18a for closing the pharmaceutical container 18 when the user pushes
the pump cap 10 down to such an extent that a discharge process occurs. If the closure of the
pharmaceutical container 18 is designed without a metal capsule 18a, for example made from an
electrically not conducting plastic, the sensor 12b may represent a switch simply designed as an
opening or closing switch. Instead of this switch sensor, here a capacitive, magnetic, or other
sensor 12b may also be provided for detecting a pumping process, so that the electronic unit 12
can transmit to the personal digital assistant PDA a signal appropriately reflecting the drug
discharge process.
Otherwise, the electronic unit 12 is consistent with the variant described in the context with Figs.
1 and 1a. The plastic material of the insert represents, in the variant of Fig. 2, a layer of plastic
film, for example made from plastic, such as polyethylene (PE) or polyvinyl chloride (PVC) with
a thickness of approximately 100 μm. The antenna 12a, here designed as a coil antenna, is
applied on this plastic film and contacts the electronic unit 12, which comprises also the sensor
12b.
In the variant of Fig. 3, unlike in the variant of Fig. 2, the inlay is designed in several layers, with
the plastic material of the inlay in the variant of Fig. 3 representing several laminated layers of
synthetic film, for example plastics such as polyethylene (PE) or polyvinyl chloride (PVC)
showing a thickness of 75 μm. The windings of the coil antenna 12a are located between the
individual layers. In this stack of plastic films, in one variant, in addition to the antenna 12a also
the operating energy storage unit 12c is located. With regards to sizing and design of the coil
antenna 12a in its different variants discussed above, reference is made for example to “Antenna
Circuit Design for RFID Applications”, AN710, Youbok Lee, Ph.D., 2003 Microchip
Technology Inc. Another literature source for sizing and design of the coil antenna 12a, also
dependent on the various different RFID-chips that can be inserted in the electronic unit, is
“RFID Design Fundamentals and Applications”, Albert Lozano-Nieto, CRC Press Taylor &
Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742, '
2011 by Taylor and Francis Group, LLC. Another example of literature for sizing and design of
the coil antenna 12a is “Design of Antennas for RFID Application”, Ming-Tao Zhang et al. in
“Development and Implementation of RFID Technology” edited by Cristina TURCU, ISBN
9789026137, pp. 554, February 2009, I-Tech, Vienna, Austria.
The pump cap with the corresponding electronic unit 12 according to Fig. 1, or the pump cap 10
with an inlay according to Figs. 2 and 3, is combined with a pharmaceutical container 18 to form
another container, and a nasal spray is located in the pharmaceutical container, for example in
the form of a solution or suspension, preferably Dymista® nasal spray, a combination of
azelastine hydrochloride and Fluticasone propionate, with 1 g suspension comprising 1,000
microgram azelastine hydrochloride and 365 microgram fluticasone propionate, and with one jet
of 0.14 g comprising 137 microgram azelastine hydrochloride and 50 microgram fluticasone
propionate, and with the other components of the nasal spray representing disodium edetate,
glycerol, micro-crystalline cellulose, and carmellose sodium, polysorbate 80, benzalconium
chloride, phenyl-ethyl alcohol, and purified water.
The computer program product running on the personal digital assistant PDA in preparation
mode VBM causes the pairing of a respective electronic unit 12 in (an inlay or directly in) the
pump cap 10 with the personal digital assistant PDA. For this purpose, the user starts the
preparation mode of the computer program product and brings the personal digital assistant PDA
into the spatial proximity of the pump cap 10 comprising the electronic unit 12. In the
preparation mode VBM of the computer program product, this initiates the emission of
electromagnetic energy according to the NFC-standard ISO / IEC 14443 A and B or ISO / IEC
15693 via the NFC-functionality (coils, control electronic, appropriate NFC-control software
(=NFC protocol stack) in the processor operating system) of the personal digital assistant PDA.
As soon as the electronic unit 12 receives sufficient electromagnetic energy via its coil antennae
12a from the antenna in the personal digital assistant PDA, the electronic unit 12 is activated and
reacts with the confirmation signal transmitted by its coil antenna 12a. Now, the personal digital
assistant PDA transmits, for example an (alphanumeric) multi-digit individualized identification,
which is received by the electronic unit 12 via the antenna 12a and is saved in a non-volatile
storage unit of the chip of the electronic unit 12, the EEPROM, which is not shown in greater
detail here.
Alternatively, it is also possible that after the activation of the electronic unit 12, said unit also
transmits from the memory unit of the chip a multi-digit individualized identification stored
there, for example an alphanumerical one, via the antenna 12a to the personal digital assistant
PDA.
In both variants it is achieved that, on the one hand, the personal digital assistant PDA and, on
the other hand, the electronic unit 12 in the pump cap 10, are adjusted to each other. Here, during
the later receipt of discharge processes from the pharmaceutical container 18 from signals
reflecting the activation of the pump cap 10, the computer program product can reliably allocate
these signals exclusively to this very assembly, and not to any other one, and process them
accordingly. Additionally, a discharge meter is reset to zero.
In order to record with the personal digital assistant PDA and the simultaneously running
computer program product, any signals reflecting discharge processes from the pharmaceutical
container 18 by activation of the pump cap 10 and to allow displaying them on the monitor of the
personal digital assistant PDA, in a wake-up mode AWM, the electronic unit 12 is activated
(located in an inlay or directly in) the pump cap 10.
For this purpose, the user starts the computer program product and brings the personal digital
assistant PDA into the spatial proximity of the pump cap 10 comprising the electronic unit 12. In
the preparation mode VBM of the computer program product, it initiates the transmission of
electromagnetic energy according to the NFC-standard ISO / IEC 14443 A and B or in ISO / IEC
15693 via the NFC-functionality (coils, control electronic, appropriate NFC-control software
(=NFC protocol stack) in the processor operating system) of the personal digital assistant PDA.
As soon as the electronic unit 12 receives sufficient electromagnetic energy via its coil antenna
12a from the antenna of the personal digital assistant PDA, the electronic unit 12 is activated.
Once the transmitted electromagnetic energy is sufficient, the electronic unit 12 transmits a brief
“active signal” together with its individualized identification to the personal digital assistant
PDA. This occurs commonly within one or two seconds after the user has brought the personal
digital assistant PDA into spatial proximity of the pump cap 10 comprising the electronic unit 12.
The receipt of the “active signal” and thus the readiness of the personal digital assistant PDA to
detect discharge processes from the pharmaceutical container 18 by signals reflecting the
activation of the pump cap 10, processing and ability to display these signals on the monitor of
the personal digital assistant PDA are indicated by the computer program product by an
appropriate acoustic or visual message on the monitor of the personal digital assistant PDA.
In the next step of the computer program product, the personal digital assistant PDA is kept in
receiver mode EM. In this receiver mode EM, the computer program product waits for the user
operating the pump cap 10 such that the electronic unit 12 transmits via its coil antenna 12a
signals which reflect discharge processes from the pharmaceutical container 18 by activating the
pump cap 10.
In order to prevent that the counting of the discharge processes is dependent on the operation of
the pump cap 10 by the user, all activations of the pump cap 10 are transmitted by the electronic
unit 12 to the personal digital assistant PDA. The computer program product however evaluates
how much time elapses between two activations of the pump cap 10. If very short intervals
(approximately 1 – 4 seconds) are signalized between two or more activations of the pump cap
by the electronic unit 12, this shall be categorized by the computer program product as a so-
called priming of the pharmaceutical container 18;
the computer program product abstains from increasing the discharge meter but shows the
present status on the monitor of the personal digital assistant PDA.
If two activations of the pump cap 10 are signaled by the electronic unit 12 in short intervals
(approximately 4 – 10 seconds) to the personal digital assistant PDA, this is categorized by the
computer program product as two discharge events (one discharge process for each nostril of the
user); the computer program product accordingly increases the discharge meter and shows the
present status on the monitor of the personal digital assistant PDA. Additionally, this number of
discharge processes is saved together with a current date/time stamp in the memory of the
personal digital assistant PDA for later use.
In the present case, a differentiation is described between the so-called priming of the
pharmaceutical container 18 and two discharge processes using different temporal intervals
between two activations of the pump cap 10. In one variant, not shown in greater detail, it is
provided in case of two activations of the pump cap 10, regardless of the time interval, to
increase in the computer program product the discharge meter accordingly and to display the
current status on the monitor of the personal digital assistant PDA. If more than two activations
of the pump cap 10 are signaled within a predetermined period, e.g., 5 - 15 seconds, to the
computer program product, in another variant, not shown in greater detail either, the discharge
meter in the computer program product is increased by two and the current status is displayed on
the monitor of the personal digital assistant PDA.
Another variant provides, after the pairing of a respective electronic unit 12 (in an inlay or
directly in) the pump cap 10 with the personal digital assistant PDA, in a first step to prompt the
user for priming using a message on the monitor of the personal digital assistant PDA. Here, the
signalized interval is recorded and saved in the computer program product for comparison of the
signal progression for later activations of the pump cap 10. In a second step, using a message on
the monitor of the personal digital assistant PDA, then the user is prompted to execute two
discharge processes (one discharge event for each nostril of the user). Here, the signaled interval
is also recorded and saved in the computer program product for comparison of the signal
progression in case of later operation of the pump cap 10.
In a subsequent operation of the pump cap 10, the temporal progression of the activations of the
pump cap 10 signaled is compared to the saved progressions. Depending on the categorized
activations of the pump cap 10, then the computer program product increases the discharge meter
accordingly by two (or not, if the operations were categorized as priming) and the current status
is displayed on the monitor of the personal digital assistant PDA.
In addition to the above-described functionalities of the computer program product, here, a
history display mode HDM is provided, which displays the discharge events counted since the
most recent pairing of the respective electronic unit 12 of the pump cap 10 with the personal
digital assistant PDA, respectively provided with time/date stamp, on the monitor of the personal
digital assistant PDA. For this purpose, the discharge processes saved in the personal digital
assistant PDA are read from the memory of the personal digital assistant PDA together with the
respective date/time stamp and processed into a list or graph, and indicated for example along a
timeline.
Furthermore, an application reminder mode EEM is provided, in which the user can enter one or
more times of day or intervals at which the user shall respectively perform the next
administration. It is displayed on the monitor of the personal digital assistant PDA how much
time remains until the next administration. At the specified point of time of administration, the
personal digital assistant PDA then triggers an optic and/or acoustic and/or haptic alarm.
The presently described functionalities of the computer program product can also be integrated
in a computer program product (app), which furthermore allows a number of other functions and
options for the user. For example, various symptoms can be documented in their severity and
frequency and perhaps correlated to the administration cycle of the medication.
The above-described variants as well as their design and operating aspects serve only for the
better understanding of the structure, the functionality, and the features; they have no limiting
effect upon the disclosure, for example to the design examples. The figures are partially
schematic, with essential features and functions being shown sometimes considerably enlarged in
order to illustrate functions, effects, technical designs, and features. Here, each functionality,
each principle, each technical feature, and each characteristic disclosed in the figures or the text
can be combined with all claims, all features in the text, and in the other figures, other
functionalities, principles, technical designs, and features included in this disclosure or resulting
therefrom, in a free and arbitrary fashion such that all possible combinations of the described
variants shall be included, here.
Here, combinations between all individual designs in the text are also possible; this means in
every section of the description, in the claims, and also combinations between different variants
in the text, in the claims and the figures. The claims shall also not be considered limited to their
disclosure and thus shall not exclude any potential combinations of all features shown. All
disclosed features are explicitly also disclosed individually and in combination with all other
characteristics.
Claims (20)
1. Pump cap inlay for a pharmaceutical container, including one or more plastic foils whose outside diameters are smaller than the inside diameter of a pump cap and which have a passage opening for a medicine discharge connection piece of a pharmaceutical container, wherein the inlay also includes an electronic unit, which is a transmitter that includes a chip module and an antenna designed as a coil or dipole, and wherein the chip module of the transmitter and the antenna are fitted to the plastic foils, wherein the electronic unit is adapted to - register activation of the pump cap relative to the pharmaceutical container by a user to discharge the content of the pharmaceutical container, - wirelessly emit signals indicating activation(s) of the pump cap, and - receive operational energy for (i) registration of one or more activations of the pump cap by a user, and (ii) wirelessly emitting signals indicating one or more activations of the pump cap, wirelessly from the outside by an electronic device in form of a personal digital assistant (PDA).
2. Pump cap inlay for a pharmaceutical container according to claim 1, wherein the electronic unit of the inlay is for the contactless, automated registration and/or retrieval of data in/out of the chip, and wherein the registered data includes a personalized identifier of the pump cap for pairing with a computer program product on the personal digital assistant (PDA) and the retrieved data comprises the signals indicating the activation of the pump cap.
3. Pump cap inlay for a pharmaceutical container according to any one of the preceding claims, wherein the transmitter is integrated in the inlay and adapted to either only receive its operational energy from the personal digital assistant, if the user activates the corresponding computer program product on the personal digital assistant or adapted to receive its operational energy permanently from the personal digital assistant (PDA) provided that the pump cap on the pharmaceutical container comprising the inlay is physically close to the personal digital assistant and said radiates energy via its corresponding antenna(e).
4. Pump cap inlay for a pharmaceutical container according to any one of the preceding claims, wherein the electronic unit is adapted to receive the operational energy from the personal digital assistant in the form of a mobile or cordless phone, a so-called smart phone, a smart watch, a tablet computer, a notebook, a personal digital assistant (PDA) or something similar.
5. Pump cap inlay for a pharmaceutical container according to any one of the preceding claims, wherein the electronic unit comprises a transmitter adapted to wirelessly emit signals indicating activations of the pump cap via near-field communication - NFC - and/or to wirelessly receive operational energy.
6. Pump cap inlay for a pharmaceutical container according to any one of the preceding claims, wherein the electronic unit is equipped with a sensor comprising a switch adapted to register a discharge process, preferably comprising two electrical contacts adapted and arranged in a way that they are electrically bridged via a metallic component of the pharmaceutical container if the user presses down the pump cover together with the inlay located therein to cause a discharge process or the switch is an opening or closing switch, provided that the sensor is adapted to interact with the pharmaceutical container whose cap is designed without a metal capsule.
7. Pump cap inlay for a pharmaceutical container according to any one of the preceding claims, wherein the foil material of the inlay is one or several layers of wood-free paper, coating paper or paper stuffed with resin, plastic and/or plastic foils from synthetic material such as Polyethylene (PE), Polyvinyl chloride (PVC), Polyvinyl chloride-Acetate-Copolymer, Polyethylene terephthalate (PET) or glycol-modified Polyethylene terephthalate (PETG), Polyethylene naphthalate (PEN), Acrylonitrile-Butadiene-Styrene-Copolymers (ABS), Polyvinyl butyral (PVB), Polymethyl-methacrylate (PMMA), Polyimide (PI), Polyvinyl alcohol (PVA), Polystyrene (PS), Polyvinyl phenol (PVP), Polyethylene (PE), Polypropylene (PP), Polycarbonate (PC) or their derivatives containing foils with a thickness of at least 75 µm or more.
8. Pump cap for a pharmaceutical container, including a pump cap inlay according to claim 1.
9. Pump cap for a pharmaceutical container according to claim 8, wherein the electronic unit of the inlay is for the contactless, automated registration and/or retrieval of data in/out of the chip, and wherein the registered data includes a personalized identifier of the pump cap for pairing with a computer program product on the personal digital assistant (PDA), and the retrieved data comprises the signals indicating the activation of the pump cap.
10. Pump cap for a pharmaceutical container according to claim 9, wherein the transmitter is adapted to either only receive its operational energy from the personal digital assistant, if the user activates the corresponding computer program product on the personal digital assistant or adapted to receive its operational energy permanently from the personal digital assistant (PDA) provided that the pump cap on the pharmaceutical container is physically close to the personal digital assistant and said radiates energy via its corresponding antenna(e).
11. Pump cap for a pharmaceutical container according to any one of claims 8 to 10, wherein the electronic unit is adapted to receive the operational energy from the personal digital assistant in the form of a mobile or cordless phone, a so-called smart phone, a smart watch, a tablet computer, a notebook, a personal digital assistant (PDA) or something similar.
12. Pump cap for a pharmaceutical container according to any one of claims 8 to 11, wherein the electronic unit comprises a transmitter adapted to wirelessly emit signals indicating activations of the pump cap via near-field communication - NFC - and/or to wirelessly receive operational energy.
13. Pump cap for a pharmaceutical container according to any one of claims 8 to 12, wherein the electronic unit is equipped with a sensor comprising a switch adapted to register a discharge process, preferably comprising two electrical contacts adapted and arranged in a way that they are electrically bridged via a metallic component of the pharmaceutical container if the user presses down the pump cover together with the inlay located therein to cause a discharge process or the switch is an opening or closing switch, provided that the sensor is adapted to interact with the pharmaceutical container whose cap is designed without a metal capsule.
14. Pharmaceutical container with a pump cap inlay according to any one of claims 1 –to 7 or pump cap according to any one of claims 8 to 13.
15. A pharmaceutical container according to claim 14, wherein there is a nasal spray in the pharmaceutical container, for example in the form of a solution or suspension, preferably Dymista® nasal spray and an Azelastine HCl/Fluticasone propionate combination.
16. A computer program product adapted and programmed to provide operational energy to the electronic unit of an inlay according to any one of claims 1 to 7 or directly to the pump cap of any one of claims 8 to 13 or the pharmaceutical container of claim 14 or claim 15 through appropriate control of the personal digital assistant (PDA) and to register the discharge process of the pharmaceutical container with: - A preparatory mode (VBM) to cause a pairing of a respective electronic unit in an inlay in the pump cap with the personal digital assistant, - A wake-up mode (AWM) to activate the electronic unit in the inlay or the pump cap, - A receiver mode (EM) to wait for the user to activate the pump cap so that the electronic unit transmits signals that indicate discharge processes from the pharmaceutical container caused by activation of the pump cap, - An evaluation mode (AM) to measure elapsed time between successive activations of the pump cap and to categorize different incidents dependent on the elapsed time.
17. The computer program product according to claim 16, wherein in the preparation mode (VBM) -- the computer program product is adapted and programmed to induce the radiation of electromagnetic energy via the personal digital assistant (PDA) so that the electronic unit receives electromagnetic energy from the antenna in the personal digital assistant (PDA) via its coil antenna, through which the electronic unit is activated and reacts with a confirmation signal transmitted via its coil antenna; -- the computer program product is adapted and programmed to transmit an individualized identification that can be received by the electronic unit through their antenna and be stored in the electronic unit or the electronic unit sends out a stored individualized identification to the personal digital assistant (PDA) via its antenna, and -- the computer program product is adapted and programmed to set the discharge meter to zero.
18. The computer program product according to claim 14 or 15, wherein in the wake-up mode (AVM) -- the computer program product is adapted and programmed to cause the radiation of electromagnetic energy through the personal digital assistant (PDA) so that the electronic unit receives electromagnetic energy from the antenna in the personal digital assistant (PDA) via its coil antenna and transmits an "active signal" together with its individualized identification to the personal digital assistant (PDA); and -- the computer program product is adapted and programmed to emit audio and/or visual indication after receiving an "active signal" via the personal digital assistant (PDA) to indicate the readiness of the personal digital assistant (PDA) to register, to process and/or to display the discharge processes from the pharmaceutical container through the indication signals caused by activating the pump cap.
19. The computer program product according to claim 16, 17 or 18, wherein in the evaluation mode (AM) -- the computer program product is adapted and programmed to categorize two or more activations of the pump cap that are signaled by the electronic unit within a very short time interval as priming of the pharmaceutical container and not increase the discharge meter; -- the computer program product is adapted and programmed to categorize two or more activations of the pump cap signaled by the electronic unit within a short time interval as two discharge processes and to increase the discharge meter accordingly; and -- the computer program product stores the number of these discharge processes along with the date/time stamp in the personal digital assistant (PDA).
20. Computer program product according to claim 16, 17, 18 or 19, wherein -- the computer program product is adapted and programmed to present, in a history display mode (HDM), the counted discharge processes since the last pairing of the respective pump cap’s electronic unit with the personal digital assistant (PDA) on the screen of the personal digital assistant (PDA), each provided with a time/date stamp, and/or the computer program product is adapted and programmed to enable the user, in an application reminder mode (EEM), to input one or more day-times or time intervals into the personal digital assistant (PDA) during which the next intake should be performed, wherein the computer program product is adapted and programmed in a way that the time period remaining until the next intake is displayed on the screen of the person digital assistant (PDA) and/or the computer program product is adapted and programmed in a way that at the specified time the personal digital assist (PDA) raises an optically, acoustically, and/or haptically alarm.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102015004073.1 | 2015-03-30 | ||
DE102015004073.1A DE102015004073B3 (en) | 2015-03-30 | 2015-03-30 | Pump cap for a pharmaceutical container, insert for a pump cap for a pharmaceutical container, pharmaceutical container with the pump cap, and computer program product |
PCT/EP2016/054350 WO2016155970A1 (en) | 2015-03-30 | 2016-03-02 | Pump cap for a pharmaceutical container, insert for a pump cap for a pharmaceutical container, pharmaceutical container with the pump cap, and computer program product |
Publications (2)
Publication Number | Publication Date |
---|---|
NZ735678A NZ735678A (en) | 2021-03-26 |
NZ735678B2 true NZ735678B2 (en) | 2021-06-29 |
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