NZ729119A - Agonists that enhance binding of integrin-expressing cells to integrin receptors - Google Patents
Agonists that enhance binding of integrin-expressing cells to integrin receptorsInfo
- Publication number
- NZ729119A NZ729119A NZ729119A NZ72911911A NZ729119A NZ 729119 A NZ729119 A NZ 729119A NZ 729119 A NZ729119 A NZ 729119A NZ 72911911 A NZ72911911 A NZ 72911911A NZ 729119 A NZ729119 A NZ 729119A
- Authority
- NZ
- New Zealand
- Prior art keywords
- integrin
- compounds
- agonists
- thienylmethyl
- cells
- Prior art date
Links
- 102000006495 integrins Human genes 0.000 title abstract 4
- 108010044426 integrins Proteins 0.000 title abstract 4
- 239000000556 agonist Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000001727 in vivo Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- OTGXZYOKJQIZTK-UHFFFAOYSA-N 2-[2-[bis(thiophen-2-ylmethyl)sulfamoyl]ethyl-methylamino]-n,n-bis(thiophen-2-ylmethyl)acetamide Chemical compound C=1C=CSC=1CN(CC=1SC=CC=1)C(=O)CN(C)CCS(=O)(=O)N(CC=1SC=CC=1)CC1=CC=CS1 OTGXZYOKJQIZTK-UHFFFAOYSA-N 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- -1 N,N-disubstituted amide Chemical class 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- QWDGYRDMZTZEHQ-URXFXBBRSA-N methyl (3s)-3-(1,3-benzodioxol-5-yl)-3-[[(2s)-1-[bis(thiophen-2-ylmethyl)carbamoyloxy]hexan-2-yl]carbamoylamino]propanoate Chemical compound C([C@H](CCCC)NC(=O)N[C@@H](CC(=O)OC)C=1C=C2OCOC2=CC=1)OC(=O)N(CC=1SC=CC=1)CC1=CC=CS1 QWDGYRDMZTZEHQ-URXFXBBRSA-N 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Provided are N,N-disubstituted amide, carbamate, urea and sulphonamide compounds of the general formula (I), wherein the variables are as described in the specification. Examples of the compounds include methyl (6S,10S)-10-(1,3-benzodioxol-5-yl)-6-butyl-3,8-dioxo-1-(2-thienyl)-2-(2-thienylmethyl)-4-oxa-2,7,9-triazadodecan-12-oate and 2-[{ 2-[bis(2-thienylmethyl)sulfamoyl]ethyl} (methyl)amino]-N,N-bis(2-thienylmethyl)acetamide. The compounds are integrin agonists that enhance the binding of cells to integrin ligands. Further provided is a method of enhancing the retention of exogenously-introduced cells at an in vivo target site and a method for treating damaged or diseased vascular tissue comprising treating the cells with the compounds and introducing them to an in vivo target site.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ746603A NZ746603A (en) | 2010-11-16 | 2011-11-16 | Agonists that enhance binding of integrin-expressing cells to integrin receptors |
| NZ746605A NZ746605A (en) | 2010-11-16 | 2011-11-16 | Agonists that enhance binding of integrin-expressing cells to integrin receptors |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41427110P | 2010-11-16 | 2010-11-16 | |
| NZ71110311 | 2011-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ729119A true NZ729119A (en) | 2018-12-21 |
Family
ID=66477021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ729119A NZ729119A (en) | 2010-11-16 | 2011-11-16 | Agonists that enhance binding of integrin-expressing cells to integrin receptors |
Country Status (1)
| Country | Link |
|---|---|
| NZ (1) | NZ729119A (en) |
-
2011
- 2011-11-16 NZ NZ729119A patent/NZ729119A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 6 YEARS UNTIL 16 NOV 2021 BY AJ PARK Effective date: 20190606 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 NOV 2022 BY ANAQUA SERVICES Effective date: 20211104 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 NOV 2023 BY ANAQUA SERVICES Effective date: 20221118 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 NOV 2024 BY ANAQUA SERVICES Effective date: 20231111 |