NZ728207A - Oligonucleotide-based inhibitors comprising locked nucleic acid motif - Google Patents

Oligonucleotide-based inhibitors comprising locked nucleic acid motif

Info

Publication number
NZ728207A
NZ728207A NZ728207A NZ72820713A NZ728207A NZ 728207 A NZ728207 A NZ 728207A NZ 728207 A NZ728207 A NZ 728207A NZ 72820713 A NZ72820713 A NZ 72820713A NZ 728207 A NZ728207 A NZ 728207A
Authority
NZ
New Zealand
Prior art keywords
oligonucleotides
chemically modified
oligonucleotide
locked nucleic
nucleic acid
Prior art date
Application number
NZ728207A
Inventor
Rooij Eva Van
Christina M Dalby
Rusty L Montgomery
Original Assignee
Miragen Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miragen Therapeutics Inc filed Critical Miragen Therapeutics Inc
Publication of NZ728207A publication Critical patent/NZ728207A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to chemical modification motifs for oligonucleotides complementary to miR-92a. The oligonucleotides of the present invention, such as chemically modified antisense oligonucleotides, can have increased in vivo efficacy. The chemically modified oligonucleotides provide advantages in one or more of potency, efficiency of delivery, target specificity, toxicity, and/or stability. The chemically modified oligonucleotides have a specific chemical modification motif or pattern of locked nucleic acids (LNAs). The oligonucleotide (e.g. antisense oligonucleotide) can target RNA, such as miRNA or mRNA. Also provided herein are compositions comprising the chemically modified oligonucleotides and methods of using the chemically modified oligonucleotides as therapeutics for various disorders, including cardiovascular disorders.
NZ728207A 2012-06-21 2013-06-21 Oligonucleotide-based inhibitors comprising locked nucleic acid motif NZ728207A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261662746P 2012-06-21 2012-06-21
US201361801533P 2013-03-15 2013-03-15
NZ70270613 2013-06-21

Publications (1)

Publication Number Publication Date
NZ728207A true NZ728207A (en) 2018-09-28

Family

ID=66476982

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ728207A NZ728207A (en) 2012-06-21 2013-06-21 Oligonucleotide-based inhibitors comprising locked nucleic acid motif

Country Status (1)

Country Link
NZ (1) NZ728207A (en)

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Effective date: 20190509

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