NZ722167A - Binding molecules targeting pathogens - Google Patents

Binding molecules targeting pathogens

Info

Publication number
NZ722167A
NZ722167A NZ722167A NZ72216713A NZ722167A NZ 722167 A NZ722167 A NZ 722167A NZ 722167 A NZ722167 A NZ 722167A NZ 72216713 A NZ72216713 A NZ 72216713A NZ 722167 A NZ722167 A NZ 722167A
Authority
NZ
New Zealand
Prior art keywords
binding domains
mhc
context
infected cells
chain
Prior art date
Application number
NZ722167A
Inventor
Ralph Alexander Willemsen
Johan Renes
Paul Steverink
Original Assignee
Apo T B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apo T B V filed Critical Apo T B V
Publication of NZ722167A publication Critical patent/NZ722167A/en

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  • Peptides Or Proteins (AREA)

Abstract

The present invention discloses that targeting infected cells for killing those infected cells can be achieved by providing a proteinaceous molecule comprising a single polypeptide chain comprising at least two specific binding domains separated by at least one linker further comprising an Fc monomer separated from said at least two specific binding domains by at least one linker, wherein said binding domains are Vh domains which specifically recognize a hepatitis C virus derived peptide in the context of MHC-1. More generally, the present invention relates to proteinaceous molecules comprising multiple recombinant antibody-fragments assembled at the DNA level into a single chain, which specifically bind hepatitis C virus derived peptide in the context of MHC-1. In addition, the invention relates to methods of diagnosing and treatment of infectious disease using these recombinant single-chain polypeptides.
NZ722167A 2012-06-26 2013-06-26 Binding molecules targeting pathogens NZ722167A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261664475P 2012-06-26 2012-06-26
US201261667859P 2012-07-03 2012-07-03
NZ70331613 2013-06-26

Publications (1)

Publication Number Publication Date
NZ722167A true NZ722167A (en) 2019-12-20

Family

ID=68847887

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ722167A NZ722167A (en) 2012-06-26 2013-06-26 Binding molecules targeting pathogens

Country Status (1)

Country Link
NZ (1) NZ722167A (en)

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Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 26 JUN 2021 BY IPAN GMBH

Effective date: 20200608

LAPS Patent lapsed