NZ715562A - Anti-viral compounds - Google Patents

Anti-viral compounds

Info

Publication number
NZ715562A
NZ715562A NZ715562A NZ71556211A NZ715562A NZ 715562 A NZ715562 A NZ 715562A NZ 715562 A NZ715562 A NZ 715562A NZ 71556211 A NZ71556211 A NZ 71556211A NZ 715562 A NZ715562 A NZ 715562A
Authority
NZ
New Zealand
Prior art keywords
pyrrolidin
compounds
benzimidazol
methyl
oxobutan
Prior art date
Application number
NZ715562A
Inventor
David A Degoey
Warren M Kati
Charles W Hutchins
Pamela L Donner
Allan C Krueger
John T Randolph
Christopher E Motter
Lissa T Nelson
Sachin V Patel
Mark A Matulenko
Ryan G Keddy
Tammie K Jinkerson
Yi Gao
Dachun Liu
John K Pratt
Todd W Rockway
Clarence J Maring
Douglas K Hutchinson
Charles A Flentge
Rolf Wagner
Michael D Tufano
David A Betebenner
Kathy Sarris
Kevin R Woller
Seble H Wagaw
Jean C Califano
Wenke Li
Daniel D Caspi
Mary E Bellizzi
William A Carroll
Original Assignee
Abbvie Bahamas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/903,822 external-priority patent/US20110092415A1/en
Priority claimed from US13/100,827 external-priority patent/US8937150B2/en
Application filed by Abbvie Bahamas Ltd filed Critical Abbvie Bahamas Ltd
Publication of NZ715562A publication Critical patent/NZ715562A/en

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Provided are compounds of general formula I, where the variables are as described in the specification. An example of the compounds is methyl { (2S)-1-[(2S)-2-{ 5-[(2R,5R)-5-{ 2-[(2S)-1-{ (2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl} pyrrolidin-2-yl]-1H-benzimidazol-5-yl} -1-(4-phenoxyphenyl)pyrrolidin-2-yl]-1H-benzimidazol-2-yl} pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl} carbamate. The compounds are inhibitors of hepatitis C virus (HCV). Further provided are processes and intermediates for preparing the compounds and pharmaceutical compositions comprising them. A preferred compound is methyl { (2S,3R)-1-[(2S)-2-{ 5-[(2R,5R)-1- { 3,5-difluoro-4-[4-(4-fluorophenyl)piperidin-1-yl]phenyl} -5-(6-fluoro-2-{ (2S)-1-[N-(methoxycarbonyl)-O-methyl-L-threonyl]pyrrolidin-2-yl} -1H-benzimidazol-5-yl)pyrrolidin-2-yl]-6-fluoro-1H-benzimidazol-2-yl} pyrrolidin-1-yl]-3-methoxy-1-oxobutan-2-yl} carbamate.
NZ715562A 2010-10-13 2011-10-12 Anti-viral compounds NZ715562A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/903,822 US20110092415A1 (en) 2009-06-11 2010-10-13 Anti-Viral Compounds
US12/964,027 US8921514B2 (en) 2009-06-11 2010-12-09 Anti-viral compounds
US201161446800P 2011-02-25 2011-02-25
US13/100,827 US8937150B2 (en) 2009-06-11 2011-05-04 Anti-viral compounds
NZ62664111 2011-10-12

Publications (1)

Publication Number Publication Date
NZ715562A true NZ715562A (en) 2017-09-29

Family

ID=59955228

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ715562A NZ715562A (en) 2010-10-13 2011-10-12 Anti-viral compounds

Country Status (1)

Country Link
NZ (1) NZ715562A (en)

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PSEA Patent sealed
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Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 12 OCT 2018 BY SPRUSON + FERGUSON

Effective date: 20180131

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Effective date: 20180917

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Effective date: 20190917

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