NZ712576B2 - Dna-pk inhibitors - Google Patents

Abstract

The present invention relates to compounds (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Description

DNA-PK INHIBITORS This application claims the benefit to US. Provisional Application No. 61/777,816, filed on March 12, 2013, the entire t of which is incorporated herein by reference.

TECHNICAL FIELD OF THE INVENTION The present ion relates to nds useful as inhibitors of DNA— dependent protein kinase (DNA-PK). The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of cancer, OUND OF THE INVENTION ng radiation (IR) induces a variety of DNA damage of which double strand breaks (DSBs) are the most cytotoxic. These DSBs can lead to cell death via apoptosis and/or mitotic catastrophe if not rapidly and completely repaired. In addition to IR, certain chemotherapeutic agents including topoisomerase II inhibitors, bleomycin, and doxorubicin also cause DSBs. These DNA lesions trigger a x set of s through the DNA damage response network that function to repair the d DNA and maintain cell viability and genomic stability. In mammalian cells, the predominant repair y for DSBs is the mologous End Joining Pathway (NHEJ). This pathway functions regardless of the phase of the cell cycle and does not require a template to re- ligate the broken DNA ends. NHEJ requires coordination of many proteins and signaling pathways. The core NHEJ machinery consists of the Ku70/80 dimer and the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), which together comprise the active DNA-PK enzyme complex. DNA-PKcs is a member of the phosphatidylinositol 3-kinase-related kinase (PIKK) family of serine/threonine protein kinases that also includes ataxia telangiectasia mutated (ATM), ataxia telangiectasia and Rad3 -related (ATR), mTOR, and four PI3K isoforms. However, while DNA-PKcs is in the same protein kinase family as ATM and ATR, these latter kinases function to repair DNA damage through the Homologous Recombination (HR) pathway and are restricted to the S and G2 phases of the cell cycle. While ATM is also recruited to sites of DSBs, ATR is recruited to sites of single stranded DNA breaks.

NHEJ is thought to proceed through three key steps: recognition of the DSBs, DNA processing to remove non-ligatable ends or other forms of damage at the termini, and finally ligation of the DNA ends. Recognition of the DSB is carried out by binding of the Ku heterodimer to the ragged DNA ends followed by recruitment of two molecules of cs to adjacent sides of the DSB; this serves to protect the broken termini until additional processing enzymes are recruited. Recent data supports the hypothesis that DNA-PKcs phosphorylates the processing enzyme, Artemis, as well as itself to prepare the DNA ends for additional processing. In some cases DNA polymerase may be required to synthesize new ends prior to the ligation step. The hosphorylation of DNA-PKcs is believed to induce a conformational change that opens the central DNA binding cavity, es DNA-PKcs from DNA, and facilitates the ultimate religation of the DNA ends.

It has been known for some time that DNA-PK'/' mice are hypersensitive to the effects of IR and that some non-selective small molecule inhibitors of cs can radiosensitize a variety of tumor cell types across a broad set of genetic backgrounds.

While it is expected that tion of DNA-PK will radiosensitize normal cells to some extent, this has been observed to a lesser degree than with tumor cells likely due to the fact that tumor cells possess higher basal levels of endogenous replication stress and DNA damage (oncogene—induced replication stress) and DNA repair mechanisms are less efficient in tumor cells. Most importantly, an improved therapeutic window with greater sparing of normal tissue will be imparted from the ation of a DNA-PK inhibitor with recent advances in precision delivery of focused IR, including image-guide RT (IGRT) and intensity-modulated RT (IMRT). tion of DNA-PK activity induces effects in both cycling and non-cycling cells. This is highly significant since the majority of cells in a solid tumor are not ly replicating at any given moment, which limits the efficacy of many agents targeting the cell cycle. Equally intriguing are recent reports that suggest a strong tion between inhibition of the NHEJ y and the y to kill traditionally radioresistant cancer stem cells (CSCs). It has been shown in some tumor cells that DSBs in t CSCs predominantly activate DNA repair through the NHEJ pathway; it is believed that CSCs are usually in the quiescent phase of the cell cycle. This may explain why half of cancer patients may experience local or distant tumor e despite treatment as current strategies are not able to effectively target CSCs. A DNA-PK inhibitor may have the ability to sensitize these potential metastatic progenitor cells to the effects of IR and select DSB-inducing chemotherapeutic agents.

Given the involvement of DNA-PK in DNA repair processes, an application of ic DNA-PK tory drugs would be to act as agents that will enhance the efficacy of both cancer chemotherapy and radiotherapy. Accordingly, it would be desirable to develop compounds useful as inhibitors of .

SUMMARY OF THE ION It has been found that compounds of this ion, and pharmaceutically acceptable compositions thereof, are effective as inhibitors of DNA-PK. Accordingly, the invention features compounds having the general formula: (I), or a pharmaceutically acceptable salt thereof, where each of R1, R2, X, Ring A, Ring B and Ring C is as d elsewhere herein. [0007A] In a particular aspect, the present invention provides a compound having the formula: (I), or a pharmaceutically acceptable salt thereof, wherein: Ring A is [FOLLOWED BY PAGE 3a] , , , , or ; Ring B is , , , , , , , , , , or , n Ring B is optionally tuted with up to 4 fluorine atoms, up to two OH, or up to two C1-4alkyl which is optionally tuted with up to 3 fluorine atoms, up to two OH, or up to two OC1-2alkyl groups; Ring C is a cyclohexane or a cyclobutane ring; X is –NH-, -O-, or -OC1-4 alkyl-; each of R1 and R2 is, independently, hydrogen, -C(O)NHR4, -C(O)OR4, -NHC(O)R4, -NHC(O)OR4, -NHC(O)NHR4, -NHS(O)2R4, -C0-4 alkyl-NHR4, or -OR4, wherein R1 and R2 cannot simultaneously be hydrogen, and wherein R1 and R2 and the intervening carbon atom can form a dioxane or dioxolane ring; R3 is hydrogen, -C1-4alkyl, fluoro, chloro, -OC1-2alkyl, -C(O)H, H, -C(O)OC1- 3 alkyl is 2alkyl, -CN, -C(O)NHC1-2alkyl, or -C(O)NH2, wherein each of said R optionally substituted with up to 3 fluorine atoms, up to two OH, or up to two -OC1- 2alkyl ; R4 is hydrogen, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C3-5cycloalkyl, phenyl, a 5 membered clic or ic heteroaryl ring selected from pyrrole, imidazole, pyrazole, triazole, thiazole, isothiazole, oxazole, pyridine, dine, pyrimidinone, pyrazine, pyridazine, and quinoline, or a 4membered monocyclic or bicyclic heterocyclyl ring selected from oxetane, tetrahydrofuran, tetrahydropyran, dihydroisoxazole, pyrimidine-2,4(1H,3H)-dione, dihydrofuropyrimidine, dihydropyranopyrimidine, dihydropyrrolopyrimidine, tetrahydropteridine, and tetrahydropyridopyrimidine, wherein each of said R4 groups is optionally substituted [FOLLOWED BY PAGE 3b] with up to four Br, Cl, F, or C1-4alkyl, up to three CN, NO2, C2-4alkenyl, C2-4alkynyl, C3-6cycloalkyl, C0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-O-C1-4 alkyl, C0-4 alkyl-O-C0-4 C3-5 cycloalkyl, C(O)OC1-4 alkyl, C(O)OC0-4 C3-5 cycloalkyl, C0-4 alkyl- C(O)NH 2, C(O)NHC1-4 alkyl, C(O)N(C1-4 alkyl) 2, C(O)NH(C0-4 alkyl-C3-5 cycloalkyl), CH 5, C 5, C 5) 5, C 2OR 0-4 alkyl-C(O)R 0-4 alkyl-C(O)N(R 2, C0-4 alkyl-C(O)OR 0-4 alkyl- NHC(O)R 5, C 5) 0-4 alkyl-N(R 2, a heterocyclic ring system selected from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, pyrrolidine, and piperazine, a heteroaryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, triazole, zole, and tetrazole, or up to two OR5, wherein each of said optional R4 substituents is optionally substituted with up to four fluorine atoms, up to two C1-4alkyl groups, up to two OH groups, up to two OC1-4alkyl groups, up to two SC1-4alkyl groups, a C(O)C1-4 alkyl, a C(O)OC1-4 alkyl, or a C(O)OC 0-4 alkyl-C3-5 cycloalkyl; and each R5 is, independently, hydrogen, C1-4alkyl, a 5membered heteroaryl selected from ole, le, thiazole, pyridine, and pyrimidine, or a 4membered heterocyclyl selected from oxetane, tetrahydrofuran, and tetrahydropyran, and each R5 group is optionally substituted with chloro, up to three fluorine atoms, up to two C1-2alkyl, CH2OH, CN, up to two OH, up to two OC1-2alkyl, a xetane, pyrrolidine, or triazole, or two R5 groups er with the intervening nitrogen atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine 0007B]In a further particular aspect, the present ion provides a compound, or a ceutically acceptable salt thereof, selected from the list of compounds in Table 1 herein. [0007C] In a still further particular aspect, the present invention provides a a compound, or a pharmaceutically acceptable salt thereof, selected from the list of compounds in Table 2 herein.

[FOLLOWED BY PAGE 3c] [0007D] In another ular aspect, the present invention provides a compound of the formula: O N O N N N O N O N H CH3 , N CH3 O , , , , , , [FOLLOWED BY PAGE 3d] or , or a pharmaceutically acceptable salt thereof. [0007E] In a still further particular aspect, the present invention provides a compound of the a: , or a ceutically acceptable salt thereof.

The invention also provides pharmaceutical compositions that include a compound of formula I and a pharmaceutically acceptable r, adjuvant, or vehicle.

These compounds and pharmaceutical compositions are useful for treating or lessening the severity of .

The compounds and compositions provided by this invention are also useful for the study of DNA-PK in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such s; and the comparative evaluation of new kinase inhibitors.

[FOLLOWED BY PAGE 4] DETAILED DESCRIPTION OF THE INVENTION Definitions and General Terminology As used , the following definitions shall apply unless otherwise indicated. For purposes of this invention, the chemical elements are identified in accordance with the Periodic Table of the Elements, CAS version, and the Handbook of Chemistry and Physics, 75th Ed. 1994. Additionally, general ples of organic chemistry are bed in “Organic Chemistry,” Thomas Sorrell, University Science Books, Sausalito: 1999, and “March’s ed Organic Chemistry,” 5th Ed., Smith, MB. and March, J., eds. John Wiley & Sons, New York: 2001, the entire contents of which are hereby incorporated by reference.

As bed herein, compounds of the invention may optionally be substituted with one or more substituents, such as are illustrated generally above, or as exemplified by particular classes, subclasses, and species of the invention. It will be appreciated that the phrase “optionally tuted” is used interchangeably with the phrase “substituted or unsubstituted.” In l, the term “substituted,” whether ed by the term “optionally” or not, refers to the replacement of one or more hydrogen radicals in a given structure with the radical of a specified substituent. Unless otherwise indicated, an optionally tuted group may have a tuent at each substitutable position of the group. When more than one position in a given structure can be substituted with more than one substituent selected from a specified group, the substituent may be either the same or different at each on.

As described herein, when the term “optionally substituted” precedes a list, said term refers to all of the subsequent substitutable groups in that list. For example, if X is halogen; optionally substituted C1_3 alkyl or phenyl; X may be either optionally substituted alkyl or ally substituted phenyl. Likewise, if the term “optionally substituted” follows a list, said term also refers to all of the substitutable groups in the prior list unless ise indicated. For example: ifX is halogen, C1_3 alkyl, or phenyl, wherein X is optionally substituted by JX, then both C1_3 alkyl and phenyl may be optionally substituted by IX. As is apparent to one having ordinary skill in the art, groups such as H, halogen, N02, CN, NHz, OH, or OCF3 would not be included because they are not substitutable groups. As is also apparent to a skilled person, a heteroaryl or heterocyclic ring ning an NH group can be optionally substituted by replacing the hydrogen atom with the substituent. If a substituent radical or structure is not identified or d as “optionally substituted,” the substituent radical or structure is unsubstituted.

Combinations of substituents envisioned by this invention are preferably those that result in the formation of stable or chemically feasible nds. The term “stable,” as used herein, refers to compounds that are not substantially altered when ted to conditions to allow for their production, detection, and, preferably, their recovery, purification, and use for one or more of the purposes disclosed herein. In some embodiments, a stable compound or chemically feasible compound is one that is not substantially altered when kept at a temperature of 40°C or less, in the e of moisture or other chemically reactive ions, for at least a week.

The term “alkyl” or “alkyl group,” as used herein, means a straight-chain (i.e., unbranched) or branched, substituted or unsubstituted hydrocarbon chain that is tely saturated. Unless otherwise specified, alkyl groups contain 1—8 carbon atoms.

In some embodiments, alkyl groups contain 1-6 carbon atoms, and in yet other embodiments, alkyl groups contain 1-4 carbon atoms (represented as “C1_4 alkyl”). In other embodiments, alkyl groups are characterized as “C0_4 alkyl” representing either a nt bond or a C1_4 alkyl chain. es of alkyl groups include methyl, ethyl, propyl, butyl, isopropyl, isobutyl, sec—butyl, and tert—butyl. The term “alkylene,” as used , represents a saturated nt straight or branched chain hydrocarbon group and is exemplified by methylene, ethylene, isopropylene and the like. The term “alkylidene,” as used , represents a divalent straight chain alkyl linking group. The term “alkenyl,” as used , represents monovalent straight or branched chain arbon group containing one or more carbon—carbon double bonds. The term “alkynyl,” as used , represents a monovalent straight or branched chain hydrocarbon group containing one or more carbon—carbon triple bonds.

The term “cycloalkyl” (or “carbocycle”) refers to a monocyclic C3—C8 hydrocarbon or bicyclic C8-C12 hydrocarbon that is completely saturated and has a single point of attachment to the rest of the molecule, and wherein any individual ring in said bicyclic ring system has 3—7 members. Suitable cycloalkyl groups include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and cycloheptyl.

The term “heterocycle,” “heterocyclyl,” “heterocycloalkyl,” or “heterocyclic” as used herein refers to a monocyclic, bicyclic, or tricyclic ring system in which at least one ring in the system contains one or more heteroatoms, which is the same or different, and that is completely saturated or that contains one or more units of unsaturation, but which is not aromatic, and that has a single point of attachment to the rest of the molecule.

In some embodiments, the “heterocycle,” “heterocyclyl,” “heterocycloalkyl,” or “heterocyclic” group has three to fourteen ring members in which one or more ring members is a heteroatom independently selected from , sulfur, nitrogen, or phosphorus, and each ring in the system contains 3 to 8 ring s.

Examples of heterocyclic rings include, but are not limited to, the following monocycles: 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydrothiophenyl, 3-tetrahydrothiophenyl, 2-morpholino, 3-morpholino, 4-morpholino, morpholino, 3- thiomorpholino, 4-thiomorpholino, l-pyrrolidinyl, 2-pyrrolidinyl, olidinyl, l-tetrahydropiperazinyl, 2-tetrahydropiperazinyl, ahydropiperazinyl, ridinyl, 2- piperidinyl, 3-piperidinyl, l-pyrazolinyl, 3-pyrazolinyl, 4-pyrazolinyl, 5-pyrazolinyl, lpiperidinyl , 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 2-thiazolidinyl, 3-thiazolidinyl, 4-thiazolidinyl, l-imidazolidinyl, 2-imidazolidinyl, 4-imidazolidinyl, 5-imidazolidinyl; and the ing bicycles: 3-lH-benzimidazolone, 3-(l-alkyl)-benzimidazol-2—one, indolinyl, ydroquinolinyl, tetrahydroisoquinolinyl, benzothiolane, benzodithiane, and 1,3 -dihydro-imidazolone.

The term “heteroatom” means one or more of oxygen, sulfur, nitrogen, or phosphorus, ing any oxidized form of nitrogen, sulfur, or phosphorus; the quatemized form of any basic nitrogen; or a tutable nitrogen of a heterocyclic ring, for example N (as in 3,4-dihydro-2H-pyrrolyl), NH (as in pyrrolidinyl) or NR+ (as in N- substituted pyrrolidinyl).

The term “unsaturated,” as used , means that a moiety has one or more units of unsaturation.

The term “alkoxy,” or “thioalkyl,” as used herein, refers to an alkyl group, as preViously defined, attached to the principal carbon chain through an oxygen (“alkoxy”) or sulfur alkyl”) atom.

The terms “haloalkyl,” “haloalkenyl,” and “haloalkoxy” mean alkyl, alkenyl, or alkoxy, as the case may be, substituted with one or more halogen atoms. The term “halogen” means F, Cl, Br, or I.

The term “aryl” used alone or as part of a larger moiety as in “aralkyl,” “aralkoxy,” or “aryloxyalkyl,” refers to a monocyclic, bicyclic, or tricyclic yclic ring system having a total of six to fourteen ring members, n said ring system has a single point of attachment to the rest of the molecule, at least one ring in the system is aromatic and wherein each ring in the system contains 4 to 7 ring members. The term “aryl” may be used interchangeably with the term “aryl ring.” Examples of aryl rings include phenyl, naphthyl, and anthracene.

The term “heteroaryl,” used alone or as part of a larger moiety as in “heteroaralkyl,” or “heteroarylalkoxy,” refers to a monocyclic, bicyclic, and tricyclic ring system haVing a total of five to fourteen ring members, n said ring system has a single point of attachment to the rest of the molecule, at least one ring in the system is aromatic, at least one ring in the system contains one or more heteroatoms independently selected from nitrogen, oxygen, sulfur or orus, and wherein each ring in the system contains 4 to 7 ring members. The term “heteroaryl” may be used interchangeably with the term “heteroaryl ring” or the term “heteroaromatic.” Further examples of heteroaryl rings include the ing monocycles: 2-furanyl, 3-furanyl, N—imidazolyl, azolyl, 4-imidazolyl, 5-imidazolyl, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, N-pyrrolyl, 2-pyrrolyl, 3- pyrrolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, pyridazinyl (e.g., 3-pyridazinyl), 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, tetrazolyl (e. g., 5- tetrazolyl), triazolyl (e.g., 2-triazolyl and 5-triazolyl), 2-thienyl, 3-thienyl, pyrazolyl (e.g., 2-pyrazolyl), isothiazolyl, 1,2,3-oxadiazolyl, 1,2,5-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,3-triazolyl, thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,5-thiadiazolyl, pyrazinyl, 1,3,5- nyl, and the following es: benzimidazolyl, benzofuryl, benzothiophenyl, l (e.g., 2-indolyl), purinyl, inyl (e. g., 2-quinolinyl, 3-quinolinyl, 4-quinolinyl), and isoquinolinyl (e.g., l-isoquinolinyl, 3-isoquinolinyl, or 4-isoquinolinyl)..

As bed herein, a bond drawn from a substituent to the center of one ring within a multiple-ring system (as shown below) represents substitution of the substituent at any substitutable position in any of the rings within the multiple ring system. For example, Structure a represents possible substitution in any of the positions shown in Structure b.

WO 59690 X X | .

/ ) I N X N X H | X X Structure a Structure b This also applies to multiple ring systems fused to optional ring systems (which would be represented by dotted lines). For example, in Structure c, X is an optional tuent both for ring A and ring B. ure c If, however, two rings in a multiple ring system each have different substituents drawn from the center of each ring, then, unless otherwise specified, each substituent only represents substitution on the ring to which it is attached. For example, in Structure d, Y is an ally tuent for ring A only, and X is an al substituent for ring B only.

\Zr'_‘\‘ | A B _,_x /, , Structure d The term “protecting group,” as used herein, represent those groups intended to protect a functional group, such as, for example, an alcohol, amine, carboxyl, carbonyl, etc., against undesirable reactions during synthetic procedures. Commonly used protecting groups are disclosed in Greene and Wuts, Protective Groups In Organic Synthesis, 3rd Edition (John Wiley & Sons, New York, 1999), which is incorporated herein by reference. Examples of nitrogen protecting groups include acyl, aroyl, or carbamyl groups such as formyl, acetyl, propionyl, pivaloyl, t-butylacetyl, 2-chloroacetyl, 2- bromoacetyl, roacetyl, trichloroacetyl, phthalyl, o-nitrophenoxyacetyl, oc- chlorobutyryl, benzoyl, 4-chlorobenzoyl, 4-bromobenzoyl, obenzoyl and chiral auxiliaries such as protected or unprotected D, L or D, L-amino acids such as alanine, leucine, phenylalanine and the like; sulfonyl groups such as benzenesulfonyl, p— toluenesulfonyl and the like; carbamate groups such as benzyloxycarbonyl, pchlorobenzyloxycarbonyl , oxybenzyloxycarbonyl, p-nitrobenzyloxycarbonyl, 2- nitrobenzyloxycarbonyl, p-bromobenzyloxycarbonyl, 3,4-dimethoxybenzyloxycarbonyl, 3,5—dimethoxybenzyloxycarbonyl, 2,4-dimethoxybenzyloxycarbonyl, 4- methoxybenzyloxycarbonyl, 2-nitro-4,5-dimethoxybenzyloxycarbonyl, 3,4,5- trimethoxybenzyloxycarbonyl, l-(p-biphenylyl)— l -methylethoxycarbonyl, dimethyl- 3,5—dimethoxybenzyloxycarbonyl, benzhydryloxycarbonyl, t-butyloxycarbonyl, ropylmethoxycarbonyl, isopropyloxycarbonyl, carbonyl, methoxycarbonyl, allyloxycarbonyl, 2,2,2,-trichloroethoxycarbonyl, phenoxycarbonyl, 4-nitrophenoxy carbonyl, fluorenylmethoxycarbonyl, cyclopentyloxycarbonyl, adamantyloxycarbonyl, cyclohexyloxycarbonyl, phenylthiocarbonyl and the like, arylalkyl groups such as benzyl, triphenylmethyl, benzyloxymethyl and the like and silyl groups such as trimethylsilyl and the like. Preferred N—protecting groups are formyl, acetyl, benzoyl, pivaloyl, t-butylacetyl, alanyl, phenylsulfonyl, benzyl, loxycarbonyl (Boc) and oxycarbonyl (Cbz).

Examples of hydroxyl protecting groups include ethers, such as tetrahydropyranyl, tert butyl, benzyl, allyl, and the like; silyl ethers such as trimethyl silyl, triethyl silyl, triisopropylsilyl, tert-butyl diphenyl silyl, and the like; esters such as acetyl, trifluoroacetyl, and the like; and carbonates. Hydroxyl protecting groups also include those appropriate for the protection of phenols.

Unless otherwise depicted or , structures recited herein are meant to include all isomeric (e. g., enantiomeric, diastereomeric, and geometric (or conformational)) forms of the ure; for e, the R and S configurations for each asymmetric , (Z) and (E) double bond isomers, and (Z) and (E) conformational isomers. Therefore, single stereochemical isomers as well as enantiomeric, diastereomeric, and geometric (or conformational) mixtures of the present compounds are within the scope of the invention. Compounds that have been drawn with stereochemical centers def1ned, usually through the use of a hatched (will) or bolded (—-) bond, are stereochemically pure, but with the absolute stereochemistry still undefined. Such compounds can have either the R or S uration. In those cases where the absolute configuration has been determined, the chiral (s) are labeled (R) or (53 in the drawing.

Unless otherwise stated, all tautomeric forms of the compounds of the invention are within the scope of the invention. Additionally, unless otherwise stated, ures depicted herein are also meant to include compounds that differ only in the presence of one or more isotopically enriched atoms. For example, nds having the present structures except for the replacement of hydrogen by deuterium or tritium, or the replacement of a carbon by a 13C— or 14C—enriched carbon are within the scope of this invention. Such compounds are useful, for example, as analytical tools, probes in ical assays, or as DNA-PK inhibitors with an improved therapeutic profile.

Description ofCompounds 0fthe Invention In one aspect, the invention features compounds having the formula: X N R1@ 0 9 (I), n Ring A is a ring system selected from R3 R3 R3 R3 ”Ql QSNQ‘lQN SQNA/ / ‘/ Ring B is a ring system selected from [Jooooooooh) wherein Ring B is optionally substituted with up to 4 fluorine atoms, up to two OH or up to two C1_4alkyl which is optionally substituted with up to 3 fluorine atoms, up to two OH, or up to two OC1_2alkyl groups; Ring C is a cyclohexane or a cyclobutane ring; X is —NH-, -O-, or -OC1_4 alkyl-; each of R1 and R2 is, independently, hydrogen, —C(O)NHR4, —C(O)OR4, —NHC(O)R4, —NHC(O)OR4, )NHR4, —NHS(O)2R4, —co_4 alkyl—NHR4, or —OR4, n R1 and R2 cannot simultaneously be en, and wherein R1 and R2 and the intervening carbon atom can form a dioxane or dioxolane ring; R3 is hydrogen, -C1_4alkyl, fluoro, chloro, —OC1_2alkyl, —C(O)H, —C(O)OH, —C(O)OC1_ zalkyl, —CN, —C(O)NHC1_2alkyl, or -C(O)NH2, wherein each of said R3 alkyl is optionally substituted with up to 3 fluorine atoms, up to two OH, or up to two 0C1- zalkyl groups; R4 is hydrogen, C1_4alkyl, C2_4alkenyl, C2_4alkynyl, C3_5cycloalkyl, phenyl, a 5 membered monocyclic or ic heteroaryl ring selected from pyrrole, imidazole, pyrazole, triazole, thiazole, isothiazole, oxazole, pyridine, pyrimidine, pyrimidinone, pyrazine, pyridazine, or quinoline, or a 4—lO—membered monocyclic or bicyclic heterocyclyl ring selected from oxetane, tetrahydrofuran, tetrahydropyran, dihydroisoxazole, pyrimidine-2,4(lH,3H)—dione, dihydrofuropyrimidine, opyranopyrimidine, opyrrolopyrimidine, tetrahydropteridine, or tetrahydropyridopyrimidine, wherein each of said R4 groups is optionally substituted with up to four Br, Cl, F, or C1_4alkyl, up to three CN, NOZ, C2_4alkenyl, C2_4alkynyl, C3_6cycloalkyl, C0_4 alkyl-C3_5 cycloalkyl, C0_4 alkyl-O-C1_4 alkyl, C0_4 O-C0_4 C3_5 lkyl, C(O)OC1_4 alkyl, C(O)OC0_4 alkyl-C3_5 cycloalkyl, C0_4 alkyl- C(O)NH2, C(O)NHC1_4 alkyl, C(O)N(C1_4 alkyl)2, C(O)NH(C0_4 alkyl—C3_5 cycloalkyl), CHZORS, 00.4 alkyl—C(O)R5, 00.4 alkyl—C(O)N(R5)2, 00.4 alkyl—C(O)OR5, 00.4 alkyl- NHC(O)R5, C0_4 alkyl-N(R5)2, a heterocyclic ring system selected from oxetane, ine, ydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, idine or zine, a heteroaryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, le, oxadiazole or tetrazole, or up to two 0R5, wherein each of said optional R4 substituents is optionally substituted with up to four fluorine atoms, up to two C1_4alkyl groups, up to two OH groups, up to two OC1_4alkyl groups, up to two SC1_4alkyl groups, a C(O)C1_4 alkyl, a C(O)OC1_4 alkyl, or a C(O)OC0_4 alkyl—C3_5 cycloalkyl, and each R5 is, independently, hydrogen, C1_4alkyl, a 5—6—membered heteroaryl selected from imidazole, le, thiazole, pyridine, or pyrimidine, a 4membered heterocyclyl selected from oxetane, tetrahydrofuran, or tetrahydropyran, and each R5 group is optionally substituted with chloro, up to three fluorine atoms, up to two kyl, CHzOH, CN, up to two OH, up to two OC1_2alkyl, a xetane, pyrrolidine, or triazole, or two R5 groups together with the intervening nitrogen atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

In one embodiment, Ring C is utane.

In another aspect, the invention features nds having the formula: X N 9 (11), wherein R1 and R2 are as defined for compounds of formula I.

In another aspect, the invention features compounds having the formula: ,x N R23... 0 , wherein R2 is as defined for compounds of formula 1.

In another aspect, the invention es compounds having the formula: NA/j X II / N a (II-A-l), wherein R2 is as defined for compounds of formula I.

In another aspect, the invention features compounds having the formula: WO 59690 ,X N a (II-B), wherein R1 is as defined for compounds of formula 1.

In another aspect, the invention features compounds having the formula: IX N a (II-B-l), wherein R1 is as defined for nds of formula I.

In one embodiment, R1 is -C0_4 alkyl-NHR4.

In another ment, X is —O- or —OC1_4 alkyl—.

In one embodiment, Ring C is cyclohexane.

In another aspect, the invention es compounds having the formula: a (111), wherein R1 is as defined for compounds of formula I.

In one embodiment, X is —NH—.

In another aspect, the invention features compounds having the formula: H A N N R2“NO, 6 ), wherein R2 is as defined for compounds of formula I.

In another aspect, the invention features compounds having the formula: H \ I /N U oN /N O; e (III-A-1)0r (III-A-Z), wherein R2 is as defined for compounds of formula I.

In one embodiment, R2 is —co_4 alkyl—NHR4 or —OR4.

In another embodiment, R2 is -NHR4 or -OR4.

In another aspect, the invention features nds having the formula: H A U” DN 6 ), wherein R1 is as defined for compounds of formula 1.

In another aspect, the invention features compounds having the formula: N \/\7 N/O H H ‘ I / N R10N UN UN / (III-B-l) or (III-B- 2), wherein R1 is as defined for compounds of formula I. 2014/024767 In one embodiment, R1 is -C0_4 alkyl—NHR4 or -OR4.

In r embodiment, R1 is -NHR4 or -OR4.

In another embodiment, X is —O-.

In another aspect, the invention features compounds having the formula: 0’0 N (III-C), wherein R2 is as defined for compounds of formula I.

In another , the invention features compounds having the formula: MIA/j N’0 0’0 ON 00 oN / R2‘\ sz“ e (III-C-l) or e (III-C-Z), wherein R2 is as defined for compounds of formula I.

In another aspect, the invention features compounds having the formula: U" o“ \:e (III-D), wherein R1 is as defined for nds of formula I.

In another aspect, the invention features compounds having the formula: N ‘/x N/O I I 9 (III-D-l) or e (III-D-Z), wherein R1 is as defined for compounds of formula I.

In one embodiment, R1 is -C0_4 alkyl—NHR4 or -OR4.

In another embodiment, R1 is -NHR4 or -OR4.

In another aspect, the invention features compounds having the a: R4,Ycor: (III-D-3), wherein Y is —O— or —NH—.

In one embodiment of nds having formula I, II, II-A, II-A-l, II-B, II- B-1,III, III-A, l, III-A-Z, III-B, III-B-l, III-B-Z, III-C, III-C-l, III-C-Z, III-D, l, III-D-Z, or III-D-3, lsUEJEflOQ In another embodiment, In another embodiment, R3 is hydrogen.

In another embodiment, R4 is hydrogen, C1_4alkyl, C2_4alkenyl, C2_4alkynyl, C3. 5cycloalkyl, phenyl, wherein each of said R4 groups is optionally substituted with up to four Br, Cl, F, or C1_4alkyl, up to three CN, N02, C2_4alkenyl, kynyl, C3_6cycloalkyl, C0_4 C3_5 cycloalkyl, C0_4 alkyl-O-C1_4 alkyl, C0_4 O-C0_4 alkyl-C3_5 cycloalkyl, C(O)OC1.4 alkyl, C(O)OC0.4 alkyl—C3.5 cycloalkyl, C0_4 alkyl—C(O)NH2, C(O)NHC1_4 alkyl, C(O)N(C1_4 alkyl)2, C(O)NH(C0_4 alkyl—C3_5 cycloalkyl), CHZORS, 00.4 alkyl—C(O)R5, 00-4 alkyl—C(O)N(R5)2, 00.4 alkyl—C(O)OR5, 00.4 alkyl—NHC(O)R5, 00.4 alkyl—N(R5)2, a heterocyclic ring system selected from oxetane, azetidine, tetrahydrofuran, opyran, tetrahydropyran, morpholine, piperidine, pyrrolidine or piperazine, a heteroaryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, triazole, oxadiazole or tetrazole, or up to two 0R5, wherein each of said al R4 substituents is optionally substituted with up to four fluorine atoms, up to two C1_4alkyl groups, up to two OH groups, up to two OC1_4alkyl groups, up to two SC1_4alkyl groups, a C(O)C1_4 alkyl, a C(O)OC1_4 alkyl, or a C(O)OC0_4 alkyl-C3_5 cycloalkyl, and each R5 is, ndently, hydrogen, C1_4alkyl, a 5—6—membered heteroaryl selected from imidazole, triazole, thiazole, ne, or pyrimidine, a 4membered heterocyclyl selected from oxetane, tetrahydrofuran, or tetrahydropyran, and each R5 group is optionally substituted with chloro, up to three fluorine atoms, up to two C1_2alkyl, CHZOH, CN, up to two OH, up to two OC1_2alkyl, a spirooxetane, pyrrolidine, or triazole, or two R5 groups together with the intervening nitrogen atom form a morpholine ring, ine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

In another embodiment, R4 is a 5—lO—membered monocyclic or bicyclic heteroaryl ring selected from pyrrole, ole, pyrazole, triazole, thiazole, azole, oxazole, pyridine, pyrimidine, pyrimidinone, pyrazine, pyridazine, or quinoline, wherein each of said R4 groups is ally substituted with up to four Br, Cl, F, or C1_4alkyl, up to three CN, N02, C2_4alkenyl, C2_4alkynyl, C3_6cycloalkyl, C0_4 alkyl-C3_5 cycloalkyl, C0_4 alkyl—O—C1_4 alkyl, C0_4 alkyl—O—C0_4 alkyl—C3_5 cycloalkyl, C(O)OC1_4 alkyl, 0_4 alkyl-C3_5 cycloalkyl, C0_4 alkyl-C(O)NH2, C(O)NHC1_4 alkyl, C(O)N(C1_4 alkyl)2, C(O)NH(C0_4 alkyl—C3_5 cycloalkyl), CHZORS, 00.4 C(O)R5, 00.4 alkyl—C(O)N(R5)2, Co_4 alkyl-C(O)OR5, Co_4 alkyl-NHC(O)R5, Co_4 alkyl-N(R5)2, a heterocyclic ring system selected from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, pyrrolidine or piperazine, a heteroaryl ring system selected from furan, e, oxadiazole, pyrrole, pyrazole, triazole, oxadiazole or ole, or up to two 0R5, wherein each of said optional R4 substituents is optionally substituted with up to four fluorine atoms, up to two C1_4alkyl groups, up to two OH groups, up to two OC1_4alkyl groups, up to two SC1_4alkyl groups, a C(O)C1_4 alkyl, a C(O)OC1_4 alkyl, or a C(O)OC0_4 alkyl-C3_5 cycloalkyl, and each R5 is, independently, hydrogen, C1_4alkyl, a mbered aryl selected from imidazole, triazole, thiazole, pyridine, or pyrimidine, a 4membered heterocyclyl selected from oxetane, tetrahydrofuran, or tetrahydropyran, and each R5 group is optionally substituted with , up to three fluorine atoms, up to two kyl, CHZOH, CN, up to two OH, up to two OC1_2alkyl, a spirooxetane, pyrrolidine, or triazole, or two R5 groups together with the intervening nitrogen atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

WO 59690 In yet another embodiment, R4 is pyridine or pyrimidine, which is optionally substituted with up to four Br, Cl, F, or C1_4alkyl, up to three CN, N02, C2_4alkenyl, C2. 4alkynyl, C3_6cycloalkyl, C0_4 alkyl-C3_5 cycloalkyl, C0_4 alkyl-O-C1_4 alkyl, C0_4 alkyl-O-C0_ 4 alkyl-C3_5 cycloalkyl, C(O)OC1_4 alkyl, C(O)OC0_4 alkyl-C3_5 lkyl, C0_4 alkyl- 2, C(O)NHC1_4 alkyl, C(O)N(C1_4 2, C(O)NH(C0_4 alkyl—C3_5 cycloalkyl), CHZORS, 00.4 alkyl—C(O)R5, 00.4 alkyl—C(O)N(R5)2, 00.4 alkyl—C(O)OR5, 00.4 alkyl- NHC(O)R5, C0_4 alkyl-N(R5)2, a heterocyclic ring system selected from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, pyrrolidine or piperazine, a heteroaryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, triazole, oxadiazole or ole, or up to two 0R5, wherein each of said optional R4 substituents is optionally tuted with up to four fluorine atoms, up to two C1_4alkyl groups, up to two OH groups, up to two OC1_4alkyl groups, up to two SC1_4alkyl groups, a C(O)C1_4 alkyl, a C(O)OC1_4 alkyl, or a C(O)OC0_4 C3_5 cycloalkyl, and each R5 is, ndently, en, C1_4alkyl, a 5—6—membered heteroaryl selected from imidazole, triazole, thiazole, pyridine, or pyrimidine, a 4membered heterocyclyl selected from oxetane, tetrahydrofuran, or tetrahydropyran, and each R5 group is optionally substituted with chloro, up to three fluorine atoms, up to two C1_2alkyl, CHZOH, CN, up to two OH, up to two OC1_2alkyl, a spirooxetane, pyrrolidine, or triazole, or two R5 groups er with the intervening nitrogen atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

In another embodiment, R4 is a embered monocyclic or bicyclic heterocyclyl ring selected from oxetane, tetrahydrofuran, tetrahydropyran, dihydroisoxazole, pyrimidine-2,4(lH,3H)-dione, dihydrofuropyrimidine, dihydropyranopyrimidine, dihydropyrrolopyrimidine, tetrahydropteridine, or tetrahydropyridopyrimidine, wherein each of said R4 groups is optionally substituted with up to four Br, Cl, F, or C1_4alkyl, up to three CN, N02, C2_4alkenyl, kynyl, C3. 6cycloalkyl, C0_4 alkyl-C3_5 cycloalkyl, C0_4 O-C1_4 alkyl, C0_4 alkyl-O-Co_4 C3_5 cycloalkyl, C(O)OC1_4 alkyl, C(O)OC0_4 alkyl-C3_5 cycloalkyl, C0_4 alkyl-C(O)NH2, C(O)NHC1_4 alkyl, C(O)N(C1_4 alkyl)2, C(O)NH(C0_4 alkyl—C3_5 lkyl), CHZORS, C0_4 alkyl—C(O)R5, 00.4 alkyl—C(O)N(R5)2, 00.4 alkyl—C(O)OR5, 00.4 alkyl—NHC(O)R5, 00.4 alkyl-N(R5)2, a heterocyclic ring system selected from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, pyrrolidine or piperazine, a aryl ring system selected from furan, oxazole, oxadiazole, pyrrole, le, triazole, oxadiazole or tetrazole, or up to two 0R5, wherein each of said optional R4 substituents is optionally substituted with up to four fluorine atoms, up to two C1_4alkyl groups, up to two OH groups, up to two OC1_4alkyl groups, up to two SC1_4alkyl groups, a _4 alkyl, a C(O)OC1_4 alkyl, or a C(O)OC0_4 alkyl-C3_5 cycloalkyl, and each R5 is, independently, hydrogen, C1_4alkyl, a 5—6—membered heteroaryl selected from imidazole, triazole, thiazole, pyridine, or pyrimidine, a 4membered heterocyclyl selected from oxetane, tetrahydrofuran, or tetrahydropyran, and each R5 group is optionally substituted with chloro, up to three fluorine atoms, up to two C1_2alkyl, CHZOH, CN, up to two OH, up to two OC1_2alkyl, a spirooxetane, pyrrolidine, or le, or two R5 groups together with the intervening nitrogen atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

In another aspect, the invention features nds haVing the formula: N/§/\‘|I Uo / N H'?‘ R“ [”1 0 (IV), wherein R3 is hydrogen, C1_4alkyl, fluoro, chloro, -OC1_2alkyl, or -C(O)NH2, _ C(O)H, or -CN, wherein each of said R3 alkyl is ally substituted with OH or up to 3 e atoms; R4 is NAX‘I R4aJ|\ x2’J\ R4b X1 is N, CH, CF, CCl, or CC1_2 alkyl optionally substituted with up to 3 fluorine atoms; X2 is N or CR“; wherein X1 and X2 cannot simultaneously be N, each of R4a and R4c is, independently, hydrogen, F, Cl, Br, CN, N02, , R“, C1_4 alkyl, C0_4 alkyl-C3-5 cycloalkyl, C0_4 alkyl-O-C1_4 alkyl, Co_4 alkyl-O-C0_4 C3_5 cycloalkyl, C2_4 alkenyl, C2_4 alkynyl, 1_4 alkyl, C(O)OC0_4 alkyl-C35 cycloalkyl, C(O)NH2, C(O)NHC1_4 alkyl, C(O)N(C1_4 alkyl)2, (C0_4 alkyl—C35 cycloalkyl), a heterocyclic ring system selected from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, or piperazine, or a heteroaryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, triazole, or tetrazole, or R“, R4a, and the intervening atoms form a dihydrofuran, a dihydropyran, or a tetrahydropiperidine heterocyclic ring system; wherein each of said R4a, R“, or R40 cyclic or heteroaryl ring systems is optionally substituted with up to four fluorine atoms, up to two C1_4 alkyl, up to two OH groups, a C(O)C1_4 alkyl, a C(O)OC1_4 alkyl, or a C(O)OC0_4 alkyl—C3-5 cycloalkyl; and wherein each of said R4a or R4c alkyl or cycloalkyl is optionally , R“, substituted with up to 2 non-geminal OH groups or up to 3 fluorine atoms.

In one embodiment, R3 is hydrogen.

In another embodiment, each of X1 and X2 is, ndently, CH or N.

In another embodiment, each of R4a and R4b is, independently, a cyclic ring system selected from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, line, dine, or piperazine, n each of said R4a or R4b heterocyclic or heteroaryl ring systems is ally substituted with up to four fluorine atoms, up to two C1_4 alkyl, up to two OH groups, a C(O)C1_4 alkyl, a C(O)OC1_4 alkyl, or a C(O)OC0_4 alkyl—C3_5 cycloalkyl; and wherein each of said R4a or R4b alkyl or cycloalkyl is optionally substituted with up to 2 non-geminal OH groups or up to 3 fluorine atoms.

In another embodiment, each of R4a and R4b is, independently, a heteroaryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, le, or tetrazole, wherein each of said R4a or R4b heterocyclic or aryl ring s is optionally substituted with up to four fluorine atoms, up to two C1_4 alkyl, up to two OH groups, a C(O)C1_4 alkyl, a C(O)OC1_4 alkyl, or a C(O)OC0_4 alkyl-C3_5 cycloalkyl; and n each of said R4a or R4b alkyl or cycloalkyl is optionally substituted with up to 2 minal OH groups or up to 3 fluorine atoms.

In another embodiment, each of R4a and R4b is, independently, hydrogen, F, Cl, Br, CN, NOZ, C1_4 alkyl, C0_4 alkyl-C3_5 cycloalkyl, C0_4 alkyl-O-C1_4 alkyl, C0_4 alkyl-O-C0_4 alkyl-C35 cycloalkyl, C2_4 alkenyl, C2_4 l, C(O)OC1_4 alkyl, C(O)OC0_4 alkyl—C35 cycloalkyl, C(O)NH2, C(O)NHC1_4 alkyl, C(O)N(C1_4 alkyl)2, or C(O)NH(C0_4 alkyl—C3_5 cycloalkyl), wherein each of said R4a or R4b heterocyclic or heteroaryl ring systems is optionally substituted with up to four fluorine atoms, up to two C1_4 alkyl, up to two OH groups, a C(O)C1_4 alkyl, a C(O)OC1_4 alkyl, or a 0_4 alkyl—C3_5 cycloalkyl; and wherein each of said R4a or R4b alkyl or cycloalkyl is optionally substituted with up to 2 non—geminal OH groups or up to 3 fluorine atoms.

In another embodiment, the invention features a compound selected from the group of compounds listed in Table l.

In another embodiment, the invention features a compound selected from the group of compounds listed in Table 2.

Compositions, Formulations, and Administration ofCompounds ofthe Invention In another embodiment, the invention es a pharmaceutical ition comprising a compound of any of the formulae described herein and a pharmaceutically acceptable excipient. In a further ment, the invention provides a pharmaceutical composition sing a compound of Table 1. In a further ment, the composition onally comprises an additional therapeutic agent.

According to another embodiment, the invention provides a composition comprising a compound of this invention or a pharmaceutically acceptable derivative thereof and a pharmaceutically acceptable carrier, adjuvant, or vehicle. In one embodiment, the amount of nd in a composition of this invention is such that is effective to measurably inhibit a DNA-PK in a biological sample or in a patient. In another embodiment, the amount of compound in the compositions of this ion is such that is effective to measurably inhibit DNA-PK. In one embodiment, the ition of this invention is formulated for administration to a patient in need of such composition. In a further embodiment, the composition of this invention is formulated for oral administration to a patient.

The term “patient,” as used herein, means an animal, preferably a mammal, and most preferably a human.

It will also be appreciated that certain of the compounds of present invention can exist in free form for treatment, or where appropriate, as a pharmaceutically acceptable derivative thereof. According to the present invention, a ceutically acceptable derivative includes, but is not limited to, pharmaceutically able gs, salts, esters, salts of such esters, or any other adduct or derivative which upon 2014/024767 administration to a patient in need is capable of providing, directly or indirectly, a compound as otherwise described herein, or a metabolite or residue thereof. As used herein, the term “inhibitory active metabolite or residue thereof ’ means that a metabolite or residue thereof is also an inhibitor of DNA-PK.

As used herein, the term aceutically acceptable salt” refers to those salts which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower s without undue ty, irritation, allergic response and the like.

Pharmaceutically acceptable salts are well known in the art. For example, S.

M. Berge et al., describe pharmaceutically acceptable salts in detail in J. Pharmaceutical es, 66: 1—19, 1977, which is incorporated herein by reference. Pharmaceutically acceptable salts of the compounds of this invention include those derived from suitable inorganic and organic acids and bases. Examples of pharmaceutically able, nontoxic acid addition salts are salts of an amino group formed with inorganic acids such as hydrochloric acid, hydrobromic acid, phosphoric acid, sulfuric acid and perchloric acid or with organic acids such as acetic acid, oxalic acid, maleic acid, tartaric acid, citric acid, succinic acid or malonic acid or by using other methods used in the art such as ion exchange. Other pharmaceutically acceptable salts include adipate, te, ascorbate, aspartate, benzenesulfonate, benzoate, bisulfate, borate, butyrate, camphorate, camphorsulfonate, citrate, entanepropionate, digluconate, dodecylsulfate, ethanesulfonate, formate, te, glucoheptonate, ophosphate, gluconate, hemisulfate, heptanoate, ate, hydroiodide, 2-hydroxy-ethanesulfonate, lactobionate, lactate, laurate, lauryl sulfate, malate, maleate, malonate, methanesulfonate, 2- naphthalenesulfonate, nicotinate, nitrate, oleate, oxalate, palmitate, pamoate, pectinate, persulfate, 3-phenylpropionate, ate, picrate, pivalate, propionate, stearate, succinate, sulfate, tartrate, thiocyanate, p-toluenesulfonate, undecanoate, valerate salts, and the like. Salts derived from appropriate bases include alkali metal, alkaline earth metal, ammonium and 4 alkyl)4 salts. This invention also envisions the quatemization of any basic nitrogen—containing groups of the compounds disclosed herein. Water or oil— soluble or dispersable products may be obtained by such quaternization. entative alkali or alkaline earth metal salts include sodium, lithium, potassium, calcium, magnesium, and the like. Further pharmaceutically acceptable salts include, when appropriate, nontoxic ammonium, quaternary ammonium, and amine cations formed using counterions such as halide, hydroxide, carboxylate, sulfate, phosphate, nitrate, C1_g sulfonate and aryl sulfonate.

As described above, the pharmaceutically acceptable compositions of the present invention onally comprise a pharmaceutically acceptable carrier, adjuvant, or vehicle, which, as used herein, includes any and all solvents, ts, or other liquid vehicle, dispersion or suspension aids, surface active agents, isotonic agents, thickening or emulsifying agents, preservatives, solid binders, lubricants and the like, as suited to the particular dosage form desired. In Remington: The Science and Practice ofPharmacy, 21st edition, 2005, ed. D.B. Troy, cott Williams & Wilkins, Philadelphia, and Encyclopedia ofPharmaceutical Technology, eds. J. Swarbrick and J. C. Boylan, 1988— 1999, Marcel Dekker, New York, the contents of each of which is incorporated by reference herein, are sed various carriers used in ating pharmaceutically acceptable itions and known techniques for the preparation thereof Except insofar as any tional carrier medium is incompatible with the nds of the invention, such as by producing any undesirable biological effect or otherwise interacting in a deleterious manner with any other component(s) of the pharmaceutically acceptable composition, its use is contemplated to be within the scope of this invention.

Some examples of materials which can serve as pharmaceutically acceptable carriers e, but are not limited to, ion gers, alumina, aluminum stearate, lecithin, serum proteins, such as human serum albumin, buffer substances such as phosphates, glycine, sorbic acid, or potassium sorbate, partial glyceride mixtures of saturated vegetable fatty acids, water, salts or electrolytes, such as protamine sulfate, disodium hydrogen ate, potassium hydrogen phosphate, sodium de, zinc salts, colloidal silica, magnesium trisilicate, polyvinyl pyrrolidone, polyacrylates, waxes, hylene—polyoxypropylene—block polymers, wool fat, sugars such as lactose, glucose and sucrose; starches such as corn starch and potato starch; cellulose and its derivatives such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; powdered tragacanth; malt; gelatin; talc; excipients such as cocoa butter and suppository waxes; oils such as peanut oil, seed oil; er oil; sesame oil; olive oil; corn oil and soybean oil; glycols; such a propylene glycol or polyethylene ; esters such as ethyl oleate and ethyl laurate; agar; buffering agents such as magnesium hydroxide and aluminum ide; alginic acid; pyrogen-free water; isotonic saline; 's solution; ethyl alcohol, and phosphate buffer solutions, as well as other non-toxic compatible lubricants such as sodium lauryl sulfate and magnesium stearate, as well as coloring agents, releasing agents, g agents, sweetening, flavoring and perfuming agents, preservatives and antioxidants can also be present in the composition, according to the judgment of the formulator.

The compositions of the present invention may be stered orally, parenterally, by inhalation spray, topically, rectally, nasally, ly, vaginally or via an implanted reservoir. The term “parenteral” as used herein includes subcutaneous, intravenous, intramuscular, intra-articular, intra-synovial, intrasternal, intrathecal, intraocular, intrahepatic, intralesional, epidural, intraspinal, and intracranial injection or infusion techniques. Preferably, the compositions are administered , intraperitoneally or intravenously. Sterile injectable forms of the compositions of this invention may be s or nous suspension. These suspensions may be formulated according to techniques known in the art using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation may also be a sterile inj ectable on or suspension in a non-toxic parenterally acceptable diluent or solvent, for example as a solution in 1,3—butanediol. Among the acceptable es and solvents that may be employed are water, 's solution and isotonic sodium chloride solution.

In on, e, fixed oils are conventionally employed as a solvent or suspending medium.

For this purpose, any bland fixed oil may be employed ing synthetic mono— or diglycerides. Fatty acids, such as oleic acid and its glyceride derivatives are useful in the preparation of injectables, as are natural pharmaceutically-acceptable oils, such as olive oil or castor oil, especially in their polyoxyethylated versions. These oil solutions or suspensions may also contain a long-chain alcohol t or dispersant, such as carboxymethyl cellulose or similar dispersing agents that are commonly used in the formulation of pharmaceutically acceptable dosage forms including ons and suspensions. Other commonly used surfactants, such as Tweens, Spans and other emulsifying agents or bioavailability enhancers which are commonly used in the manufacture of pharmaceutically acceptable solid, liquid, or other dosage forms may also be used for the purposes of formulation.

WO 59690 The pharmaceutically acceptable compositions of this invention may be orally administered in any orally acceptable dosage form ing, but not limited to, capsules, tablets, s sions or solutions. In the case of tablets for oral use, carriers commonly used include lactose and corn starch. Lubricating agents, such as magnesium stearate, are also typically added. For oral administration in a capsule form, useful diluents include lactose and dried cornstarch. When aqueous suspensions are required for oral use, the active ingredient is combined with emulsifying and suspending agents. If desired, n ning, flavoring or coloring agents may also be added.

Alternatively, the pharmaceutically acceptable compositions of this invention may be administered in the form of suppositories for rectal administration. These can be prepared by mixing the agent with a suitable ritating excipient that is solid at room temperature but liquid at rectal ature and therefore will melt in the rectum to release the drug. Such materials include cocoa butter, beeswax and polyethylene glycols.

The pharmaceutically acceptable compositions of this invention may also be administered lly, especially when the target of treatment includes areas or organs readily accessible by topical application, including diseases of the eye, the skin, or the lower intestinal tract. Suitable topical formulations are readily prepared for each of these areas or organs. l application for the lower intestinal tract can be effected in a rectal suppository formulation (see above) or in a suitable enema formulation. Topically— transdermal patches may also be used.

For topical applications, the pharmaceutically acceptable itions may be formulated in a suitable ointment containing the active component suspended or ved in one or more carriers. Carriers for topical administration of the compounds of this invention include, but are not limited to, mineral oil, liquid petrolatum, white petrolatum, ene glycol, polyoxyethylene, polyoxypropylene compound, emulsifying wax and water. Alternatively, the pharmaceutically acceptable compositions can be formulated in a suitable lotion or cream ning the active components suspended or dissolved in one or more pharmaceutically acceptable rs. Suitable carriers include, but are not limited to, mineral oil, sorbitan monostearate, polysorbate 60, cetyl esters wax, cetearyl alcohol, 2—octyldodecanol, benzyl alcohol and water.

For lmic use, the pharmaceutically able compositions may be formulated, e. g., as micronized sions in isotonic, pH adjusted sterile saline or other aqueous solution, or, preferably, as solutions in isotonic, pH ed sterile saline or other aqueous solution, either with or without a preservative such as benzylalkonium chloride.

Alternatively, for ophthalmic uses, the pharmaceutically able itions may be formulated in an ointment such as petrolatum. The pharmaceutically acceptable compositions of this invention may also be administered by nasal aerosol or inhalation.

Such compositions are prepared ing to techniques well-known in the art of pharmaceutical formulation and may be prepared as solutions in saline, employing benzyl alcohol or other suitable vatives, absorption promoters to enhance bioavailability, fluorocarbons, and/or other conventional solubilizing or dispersing agents.

Most preferably, the pharmaceutically acceptable compositions of this invention are formulated for oral administration.

Liquid dosage forms for oral administration include, but are not limited to, pharmaceutically acceptable emulsions, microemulsions, solutions, suspensions, syrups and s. In addition to the active compounds, the liquid dosage forms may contain inert diluents commonly used in the art such as, for example, water or other solvents, solubilizing agents and emulsifiers such as ethyl alcohol, isopropyl alcohol, ethyl ate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3—butylene glycol, dimethylformamide, oils (in particular, cottonseed, groundnut, corn, germ, olive, castor, and sesame oils), glycerol, ydrofurfuryl alcohol, polyethylene glycols and fatty acid esters of sorbitan, and mixtures thereof. Besides inert diluents, the oral compositions can also e adjuvants such as wetting agents, fying and suspending agents, sweetening, flavoring, and perfuming agents.

Injectable preparations, for example, sterile inj ectable aqueous or oleaginous sions may be formulated according to the known art using suitable dispersing or wetting agents and suspending agents. The sterile injectable ation may also be a sterile inj ectable solution, suspension or emulsion in a nontoxic parenterally acceptable diluent or solvent, for example, as a solution in l,3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution, U.S.P. and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil can be employed including synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid are used in the preparation of injectables.

The injectable formulations can be sterilized, for example, by filtration through a bacterial-retaining filter, or by incorporating sterilizing agents in the form of sterile solid compositions which can be dissolved or dispersed in sterile water or other e inj ectable medium prior to use.

In order to prolong the effect of a compound of the present invention, it is often desirable to slow the absorption of the compound from subcutaneous or intramuscular injection. This may be accomplished by the use of a liquid suspension of crystalline or amorphous al with poor water solubility. The rate of tion of the compound then depends upon its rate of dissolution that, in turn, may depend upon crystal size and crystalline form. atively, dissolving or suspending the nd in an oil vehicle accomplishes delayed absorption of a parenterally administered nd form.

Inj ectable depot forms are made by forming microencapsule matrices of the nd in biodegradable polymers such as polylactide—polyglycolide. Depending upon the ratio of compound to polymer and the nature of the particular polymer ed, the rate of compound release can be controlled. Examples of other biodegradable polymers include poly(orthoesters) and poly(anhydrides). Depot injectable formulations are also prepared by entrapping the compound in liposomes or mulsions that are compatible with body tissues. itions for rectal or vaginal administration are preferably suppositories which can be prepared by mixing the compounds of this invention with le non- irritating excipients or carriers such as cocoa butter, polyethylene glycol or a suppository wax which are solid at ambient ature but liquid at body temperature and therefore melt in the rectum or vaginal cavity and release the active compound.

Solid dosage forms for oral administration e capsules, tablets, pills, powders, and granules. In such solid dosage forms, the active compound is mixed with at least one inert, pharmaceutically acceptable excipient or carrier such as sodium citrate or dicalcium phosphate and/or a) fillers or extenders such as starches, lactose, sucrose, glucose, mannitol, and silicic acid, b) binders such as, for example, carboxymethylcellulose, alginates, gelatin, polyvinylpyrrolidinone, sucrose, and acacia, c) humectants such as glycerol, d) disintegrating agents such as agar-agar, calcium carbonate, potato or tapioca , alginic acid, certain silicates, and sodium ate, e) solution retarding agents such as paraffin, f) absorption accelerators such as quaternary ammonium compounds, g) wetting agents such as, for example, cetyl alcohol and glycerol monostearate, h) absorbents such as kaolin and bentonite clay, and i) lubricants such as talc, calcium stearate, magnesium stearate, solid hylene s, sodium lauryl sulfate, and es thereof. In the case of capsules, s and pills, the dosage form may also comprise ing agents.

Solid compositions of a similar type may also be employed as fillers in soft and hard-filled gelatin capsules using such excipients as lactose or milk sugar as well as high molecular weight hylene glycols and the like. The solid dosage forms of tablets, dragees, capsules, pills, and granules can be prepared with coatings and shells such as enteric coatings and other coatings well known in the pharmaceutical formulating art.

They may optionally contain opacifying agents and can also be of a composition that they release the active ingredient(s) only, or preferentially, in a certain part of the intestinal tract, optionally, in a delayed manner. Examples of embedding compositions that can be used include polymeric substances and waxes. Solid compositions of a r type may also be employed as fillers in soft and hard-filled n capsules using such excipients as lactose or milk sugar as well as high molecular weight polethylene glycols and the like.

The active compounds can also be in encapsulated form with one or more excipients as noted above. The solid dosage forms of tablets, dragees, capsules, pills, and granules can be prepared with coatings and shells such as enteric coatings, release controlling coatings and other coatings well known in the pharmaceutical formulating art. In such solid dosage forms the active compound may be admixed with at least one inert diluent such as sucrose, lactose or starch. Such dosage forms may also comprise, as is normal practice, additional substances other than inert diluents, e. g., tableting lubricants and other tableting aids such a magnesium stearate and microcrystalline cellulose. In the case of capsules, tablets and pills, the dosage forms may also comprise buffering agents. They may optionally contain opacifying agents and can also be of a composition that they release the active ingredient(s) only, or entially, in a certain part of the intestinal tract, optionally, in a d . Examples of embedding compositions that can be used include polymeric substances and waxes. 2014/024767 Dosage forms for topical or transdermal stration of a compound of this invention include ointments, pastes, creams, lotions, gels, powders, solutions, , inhalants or patches. The active component is admixed under sterile conditions with a pharmaceutically acceptable carrier and any needed preservatives or s as may be required. Ophthalmic formulation, eardrops, and eye drops are also contemplated as being within the scope of this invention. onally, the present invention contemplates the use of transdermal patches, which have the added advantage of providing controlled delivery of a compound to the body. Such dosage forms can be made by dissolving or dispensing the compound in the proper medium. Absorption enhancers can also be used to increase the flux of the compound across the skin. The rate can be lled by either providing a rate controlling membrane or by dispersing the compound in a polymer matrix or gel.

The compounds of the invention are preferably formulated in dosage unit form for ease of administration and uniformity of dosage. The expression "dosage unit form" as used herein refers to a physically discrete unit of agent appropriate for the t to be treated. It will be understood, r, that the total daily usage of the compounds and compositions of the present invention will be decided by the attending physician within the scope of sound medical judgment. The specific effective dose level for any particular patient or sm will depend upon a variety of factors including the disorder being treated and the severity of the er; the activity of the specific nd employed; the specific ition employed; the age, body weight, general health, sex and diet of the patient; the time of administration, route of administration, and rate of excretion of the specific compound employed; the duration of the treatment; drugs used in combination or coincidental with the specific nd employed, and like factors well known in the medical arts.

The amount of the compounds of the present invention that may be combined with the carrier materials to produce a composition in a single dosage form will vary depending upon the host treated, the particular mode of administration. Preferably, the compositions should be formulated so that a dosage of between 0.01 — 100 mg/kg body weight/day of the inhibitor can be administered to a patient receiving these itions.

Depending upon the particular proliferative condition or cancer to be treated, additional therapeutic agents, which are normally administered to treat or prevent that ion, may also be present in the itions of this invention. As used herein, additional therapeutic agents which are ly administered to treat or prevent a particular proliferative condition or cancer are known as “appropriate for the disease, or condition, being treated.” Examples of additional therapeutic agents are provided infra.

The amount of additional therapeutic agent present in the compositions of this invention will be no more than the amount that would normally be administered in a composition comprising that therapeutic agent as the only active agent. Preferably the amount of additional therapeutic agent in the presently disclosed compositions will range from about 50% to 100% of the amount normally present in a ition comprising that agent as the only eutically active agent.

Uses ofthe Compounds and Compositions ofthe Invention In one embodiment, the invention es a method of sensitizing a cell to a theraputic agent or a disease state that induces a DNA lesion comprising the step of contacting the cell with one or more DNA-PK inhibitors of formulae 1, II, or III, or subformula thereof (e. g., formulae I-A, I-A-l, I-A-2, I-B, I-B-l, I-B-Z, I-C, I-C-l, I-C-2, I-C-3, I-C-4, I-D, I-D-1, I-D-2, I-D-3, I-D-4, or I-D-5).

The invention further provides s of potentiating a therapeutic regimen for treatment of cancer comprising the step of administering to an individual in need thereof an effective amount of a DNA-PK inhibitor of formula I, II, or III, or a subformula thereof. In one aspect, the therapeutic n for treatment of cancer es radiation therapy.

Compounds of the invention are useful in ces where radiation therapy is indicated to enhance the therapeutic benefit of such ent. In addition, radiation therapy frequently is indicated as an adjuvent to surgery in the treatment of cancer. The goal of radiation y in the adjuvant setting is to reduce the risk of recurrence and enhance disease—free survival when the primary tumor has been controlled. Adjuvant radiation therapy is indicated in several diseases including colon, rectal, lung, gastroesophageal, and breast cancers as described below.

The invention also can be practiced by including another anti-cancer chemotherapeutic agent with a compound of the invention in a therapeutic regimen for the treatment of , with or without radiation therapy. The combination of a DNA-PK inhibitor compound of the invention with such other agents can potentiate the chemotherapeutic protocol. For example, the inhibitor nd of the invention can be stered with etoposide or bleomycin, agents known to cause DNA strand breakage.

The invention further relates to radiosensitizing tumor cells utilizing a compound of formula I, II, or III, or a subformula thereof. The preferred compounds are those as described for the pharmaceutical compositions of the invention. A compound that can sensitize” a cell, as used herein, is defined as a molecule, preferably a low molecular weight molecule, administered to s in therapeutically effective amount to increase the sensitivity of cells to electromagnetic radiation and/or to promote the treatment of diseases that are treatable with electromagnetic radiation (e.g., X-rays).

Diseases that are treatable with omagnetic ion include neoplastic diseases, benign and malignant tumors, and cancerous cells.

The present invention also provides s of treating cancer in an animal that includes administering to the animal an effective amount of a DNA-PK inhibitor such as, for example, a compound of the invention. The invention further is directed to methods of inhibiting cancer cell , including processes of cellular proliferation, veness, and asis in ical systems. Methods include use of a compound of the invention as an inhibitor of cancer cell growth. Preferably, the methods are employed to inhibit or reduce cancer cell growth, invasiveness, metastasis, or tumor incidence in living animals, such as mammals. The compounds of the invention can be used, either alone or in combination with the use of IR or one or more chemotherapeutic agents, in treating cancer or inhibiting cancer cell growth. Methods of the invention also are readily adaptable for use in assay systems, e. g., assaying cancer cell growth and properties thereof, as well as identifying compounds that affect cancer cell growth.

Tumors or sms include growths of tissue cells in which the multiplication of the cells is uncontrolled and progressive. Some such growths are benign, but others are termed “malignant” and can lead to death of the organism. Malignant neoplasms or “cancers” are distinguished from benign growths in that, in addition to exhibiting sive cellular proliferation, they can invade surrounding tissues and metastasize. Moreover, malignant neoplasms are characterized in that they show a greater loss of differentiation (greater “dedifferentiation”) and their organization relative to one r and their surrounding tissues. This property is also called “anaplasia.” Neoplasms treatable by the present invention also e solid tumors, i.e., carcinomas and sarcomas. omas include those malignant neoplasms d from epithelial cells which infiltrate (invade) the surrounding tissues and give rise to metastases.

Adenocarcinomas are carcinomas derived from glandular tissue, or from tissues which form recognizable glandular structures. r broad category of cancers includes sarcomas, which are tumors whose cells are embedded in a fibrillar or homogeneous substance like embryonic connective tissue. The invention also enables treatment of cancers of the myeloid or lymphoid systems, including leukemias, lymphomas, and other cancers that lly do not present as a tumor mass, but are distributed in the vascular or lymphoreticular systems.

DNA-PK activity can be associated with s forms of cancer in, for example, adult and pediatric oncology, growth of solid tumors/malignancies, myxoid and round cell carcinoma, locally ed tumors, metastatic cancer, human soft tissue sarcomas, including Ewing's sarcoma, cancer metastases, including lymphatic metastases, squamous cell carcinoma, particularly of the head and neck, esophageal us cell carcinoma, oral carcinoma, blood cell malignancies, ing multiple myeloma, leukemias, including acute lymphocytic leukemia, acute nonlymphocytic leukemia, c lymphocytic leukemia, chronic myelocytic ia, and hairy cell leukemia, effusion lymphomas (body cavity based lymphomas), thymic lymphoma lung cancer, including small cell lung carcinoma, cutaneous T cell lymphoma, Hodgkin's ma, non-Hodgkin's lymphoma, cancer of the adrenal cortex, ACTH-producing tumors, nonsmall cell cancers, breast cancer, including small cell carcinoma and ductal carcinoma, intestinal cancers, ing stomach cancer, colon cancer, colorectal cancer, polyps associated with colorectal neoplasia, pancreatic , liver cancer, urological cancers, including bladder cancer, including primary superficial bladder tumors, invasive transitional cell carcinoma of the bladder, and muscle—invasive bladder cancer, prostate cancer, malignancies of the female genital tract, including ovarian carcinoma, primary peritoneal epithelial sms, cervical carcinoma, uterine endometrial cancers, vaginal cancer, cancer of the vulva, uterine cancer and solid tumors in the ovarian follicle, malignancies of the male genital tract, ing testicular cancer and penile cancer, kidney cancer, including renal cell carcinoma, brain cancer, including intrinsic brain , neuroblastoma, astrocytic brain tumors, gliomas, metastatic tumor cell invasion in the central nervous system, bone s, including osteomas and osteosarcomas, skin cancers, including malignant melanoma, tumor progression of human skin keratinocytes, squamous cell cancer, thyroid cancer, retinoblastoma, neuroblastoma, peritoneal effusion, malignant pleural effusion, mesothelioma, Wilms's , gall bladder cancer, blastic neoplasms, hemangiopericytoma, and Kaposi's sarcoma. Methods to potentiate treatment of these and other forms of cancer are embraced by the invention.

The invention provides a method of inhibiting DNA-PK activity in a biological sample that includes contacting the biological sample with a nd or composition of the ion. The term “biological sample,” as used herein, means a sample e a living organism and includes, t limitation, cell cultures or extracts thereof; biopsied material obtained from a mammal or extracts thereof; and blood, saliva, urine, feces, semen, tears, or other body fluids or extracts thereof. Inhibition of kinase activity, particularly DNA—PK activity, in a biological sample is useful for a variety of purposes known to one of skill in the art. Examples of such purposes include, but are not limited to, biological specimen storage and biological assays. In one embodiment, the method of inhibiting DNA-PK activity in a biological sample is limited to non-therapeutic methods.

Preparation ofCompounds ofthe Invention As used , all abbreviations, s and tions are consistent with those used in the contemporary scientific literature. See, e. g., Janet S. Dodd, ed., The ACS Style Guide: A Manualfor Authors and Editors, 2nd Ed., Washington, DC: American Chemical Society, 1997. The following definitions describe terms and abbreviations used BPin pinacol boronate ester Brine a saturated NaCl on in water DCM dichloromethane DIAD diisopropylazodicarboxylate DIEA diisopropylethylamine DMA dimethylacetamide DMF dimethylformamide DMSO dimethylsulfoxide DTT dithiothreitol ESMS electrospray mass spectrometry EtZO ethyl ether EtOAc ethyl acetate EtOH ethyl alcohol HEPES 4-(2-hydroxyethyl)— l azineethanesulfonic acid HPLC high performance liquid chromatography IPA isopropanol LAH lithium aluminum hydride LC—MS liquid chromatography-mass spectrometry LDA lithium diisoproylethylamide Me methyl MeOH methanol MsCl methanesulfonyl chloride MTBE methyl t—butyl ether NMP N—methylpyrrolidine Pd2(dba)3 tris(dibenzylideneacetone)dipalladium(0) Pd(dppf)Clz 1,1' bis(diphenylphosphino)-ferrocene dichloro-palladium PG protecting group Ph phenyl (rac)—BINAP racemic is(diphenylphosphino)-l,l'-binaphthyl RockPhos di— tert—butyl(2',4',6'-triisopropyl-3 ,6-dimethoxy-[ l l '-biphenyl]—2— yl)phosphine RT or rt room temperature SFC supercritical fluid tography SPhos 2—dicyclohexylphosphino-2',6'-dimethoxybiphenyl TBAI tetrabutylammonium iodide tBu tertiary butyl THF tetrahydrofuran TEA triethylamine TMEDA ethylethylenediamine VPhos [3 —(2—dicyclohexylphosphanylphenyl)—2,4-dimethoxy- phenyl]sulfonyloxysodium General Synthetic Procedures In general, the nds of this invention may be prepared by methods described herein or by other methods known to those skilled in the art. e 1. General preparation of the compounds of formula G H NH2 E 1 A H A Br N Br N N N o [C] —> —> R1U F NMP, 180°C N Pol2(o|ba)3, rac—BINAP, N (step H) ngcos, toluene, 100°C [A] [0Bl] (step 1-ii) [D] PGHHEN’O/ AN deprotect HQ (step 1--iii) (UN H2N U—>(step 1--iv)R1a_|_ WHOHQ [E] [G] P Scheme 1 Compounds of formula I, n X1 is NH (i.e., compounds of formula I-A), can be prepared as outlined below in Scheme 1. Accordingly, as shown in step l—i of Scheme 1, heteroaryl compounds of formula A can be reacted with morpholine or a morpholine analog by heating the mixture in a polar, non-protic solvent to produce compounds of formula B. Utilizing a palladium-catalyzed, phosphine ligand-assisted Buchwald/Hartwig-type coupling, as shown in step l—ii of Scheme 1, a compound of formula B can be reacted with aminocyclohexanes of formula C to e compounds of formula D, wherein R1 and R2 are as described elsewhere herein. In one e, when monoprotected meso cyclohexane—l,4—diamines of a E are prepared, removal of the protecting group forms compounds of formula F, as shown in step l-iii of Scheme 1. The resulting free amine can then be reacted with various moieties having groups reactive towards amines (e.g., Rla—L, where L is a leaving group such as chloro, bromo, iodo, toluenesulfonate, methanesulfonate, or trifluoromethanesulfonate; or where L is a reactive 2014/024767 carbonyl—containing moiety such as an active ester or an isocyanato group) to produce a compound of formula G, as shown in step l—iv of Scheme 1.

Example 2. General preparation of the compounds of formula M, N, R, and S A A Ho (3N HO N protect PG’O N [“3 O deprotect —> —> —> NW: 180°C (step 24) (step 2—iii) [H] Br [J] Br (step 2—ii) [K] E j [I], N I UU or 00 base (step 2—-iv) 00 0 Scheme 2a Compounds of formula I, wherein X1 is O can be prepared as outlined below in Schemes 2a and 2b. Accordingly, as shown in step 2—i of Scheme 2a, the hydroxyl group of heteroaryl compounds of formula H can be protected to produce compounds of formula J, which can then be reacted with morpholine or a morpholine analog by heating the mixture in a polar, non-protic solvent to produce nds of formula K after removal of the protecting group, as shown in steps 2-ii and 2-iii of Scheme 2a. Subsequently, as shown in step 2—iv of Scheme 2a, a compound of formula K can be d with a compound of formula L under conditions sufficient to affect the SN2 displacement of its leaving group (e.g., where L is a leaving group such as chloro, bromo, iodo, toluenesulfonate, esulfonate, or trifluoromethanesulfonate) to produce a compound of formula M or formula M, depending on r R1 or R2 is en. In those instances when R1 or R2 are protected nitrogen or oxygen moieties, nds of the invention can be produced by removal of the protecting group and subsequent synthetic manipulation of the resulting free amine/alcohol.

WO 59690 Alternatively, as shown in Scheme 2b, the hydroxyl group of a compound of a 0 can be reacted with a compound of formula L to produce a fused bicycloheteroaryl e of formula P, which can subsequently be reacted with morpholine or a morpholine analog to produce a compound of formula M or formula N.

\\\L H m RI—O A U HO N R2 o [L] N 0 —> [M] or [N] —, NMP, 180°C base R5 (step 2—vi) [Bor] Br (step 2—v) [P] Scheme 2b Alternatively, as shown in Scheme 2c, compounds of the invention in which Ring B is a dihydropyran ring can be prepared by reacting compounds of formula Q with dialkyl (3,6—dihydro—2H—pyran—4—yl)boronates to produce compounds of formula R.

Compounds of formula R can then be uently reduced to form compounds of formula S. mm A 0 Q 61 RE (Step 2--viii)R [Q] Br Pd(dppf) Na2C03 DMF [R] {31 (step 2—-\/ii) 0 0 Scheme 2c Example 3. Preparation of ethyl (4-((7-morpholinoquinoxalin yl)amino)cyclohexyl)carbamate (Compound 6) and N1-(7-morpholinoquinoxalinyl)— N4-(pyrimidinyl)cyclohexane-1,4-diamine (Compound 18) H NH NH \ 2 ONH ”(N /N Boc\ (0’ Br NH2 Br /N N ___£L_, ___Ji______* MeOH NMP 180°C Pd2(dba)3, rac—BINAP, (step 3-i) F (step 3 ll) CsZCO3, toluene, 100°C “001] 0 (flep34m I10031 H Nfl\ N /N N \ N \ | NO 0 DIEA, 3DCM 03:0 /N /N ME IO TFAJDCM H’[::]’ (step3-v) [:::I’ (tS ep3V') (step 3- iv) * N N \ Br 1 a, 1004 [:1 [1005 0 TEA, NMP, N N 130°C v [13] E 1 Scheme 3 As shown in step 3—i of Scheme 3, to a solution of 3—bromo—5—fluoro—benzene— 1,2-diamine (compound 1001, 1.11 g, 5.41 mmol) in methanol (11 mL) was added oxaldehyde (1.57 mL of 40 % w/V, 10.8 mmol). The reaction mixture was stirred at room temperature under nitrogen. After 2 hours a yellow solid precipitated. The reaction mixture was diluted with water (20 mL), d an additional 5 minutes, filtered, and the ted solid dried under high vacuum to produce 5—bromo—7—fluoroquinoxaline (compound 1002, 868 mg, 70.6% yield): 1H—NMR (3 00 MHz, DMSO—d6) 8 9.06 (s, 2H), 8.36 (dd, J = 8.5, 2.7 Hz, 1H), 8.00 (dd, J = 9.2, 2.7 Hz, 1H); ESMS (M+H+) = 227.14.

As shown in step 3—ii of Scheme 3, to a solution of 5—bromo—7— fluoroquinoxaline (4.5 g, 19.8 mmol) in NMP (67.5 mL) was added morpholine (3.1 mL, .6 mmol). The reaction mixture was heated to 140°C and stirred for 15 hours. After cooling, the mixture was poured into water (200 mL), ted with ethyl acetate (2 x 2014/024767 100mL), dried over magnesium sulfate, filtered, evaporated under reduced re, and purified by medium pressure silica gel chromatography (10 to 80% EtOAc/hexanes gradient) to provide 4—(8-bromoquinoxalin—6—yl)morpholine (compound 1003, 3.86g, 66% yield) as a yellow solid: 1H—NMR (400 MHz, g) 5 8.82 (d, J = 1.6 Hz, 1H), 8.73 (d, J = 1.6 Hz, 1H), 8.12 (d, J = 2.5 Hz, 1H), 7.27 (d, J = 2.4 Hz, 1H), 3.87-3.69 (m, 4H), 3.44—3.34 (m, 4H); ESMS (M+H+) = 227.14.

As shown in step 3-iii of Scheme 3, a mixture of 4-(8-bromoquinoxalin yl)morpholine (1.57 g, 5.34 mmol), tert—butyl-N—(4-aminocyclohexyl)carbamate (1.37 g, 6.40 mmol), (rac)—BINAP (664 mg, 1.07 mmol), cesium carbonate (5.22 g, 16.0 mmol), and Pd2(dba)3 (489 mg, 0.534 mmol) in toluene (50 mL) was heated at 100°C for 12 hours. After cooling, the mixture was diluted with ethyl acetate (150 mL) and water (25 mL), then filtered through diatomaceous earth which was subsequently washed with ethyl acetate. The combined organics were washed with brine, dried over sodium sulfate, concentrated under reduced pressure, and purified by medium pressure silica gel chromatography (0 to 60% EtOAc/hexanes nt) to provide tert—butyl(—4—((7— morpholinoquinoxalin—5—yl)amino)cyclohexyl)carbamate (compound 1004, 1.83 g, 83.2% yield): 1H-NMR (300 MHz, CDC13) 8 8.65 (d, J = 2.0 Hz, 1H), 8.35 (d, J = 2.0 Hz, 1H), 6.60 (d, J = 2.4 Hz, 1H), 6.34 (d, J = 2.4 Hz, 1H), 6.11 (d, J = 7.8 Hz, 1H), 4.60 (s, 1H), .86 (m, 4H), 3.67 (s, 2H), 3.41-3.25 (m, 4H), 1.85 (d, J = 3.0 Hz, 5H), 1.74—1.57 (m, 3H), 1.45 (s, 9H).

As shown in step 3—iv of Scheme 3, to a solution of tert—butyl (—4—((7— morpholinoquinoxalinyl)amino)cyclohexyl)carbamate (900 mg, 2.00 mmol) in dichloromethane (16 mL) was added trifluoroacetic acid (3 mL, 38.9 mmol). The ing black reaction mixture was stirred under an atmosphere of nitrogen at room ature for 2 hours. Saturated aqueous sodium bicarbonate (150 mL) was added slowly until the color turned from black to orange. The mixture was extracted with dichloromethane (2 x 100 mL) and the combined organics washed with brine (50 mL), dried over sodium sulfate, and concentrated under reduced pressure to provide—Nl—(7— morpholinoquinoxalin—5-yl)cyclohexane—1,4-diamine, oroacetate (compound 1005): 1H NMR (300 MHz, CDCl3) 8 8.64 (d, J = 1.9 Hz, 1H), 8.36 (d, J =1.9 Hz, 1H), 6.59 (d, J = 2.3 Hz, 1H), 6.34 (d, J = 2.3 Hz, 1H), 6.20 (d, J = 7.9 Hz, 1H), 3.95-3.84 (m, 4H), 3.69 (s, 1H), 3.41-3.25 (m, 4H), 2.93 (d, J = 8.9 Hz, 1H), 2.09—1.87 (m, 2H), 1.90—1.68 (m, 6H), 1.58 (dd, J = 11.2, 8.7 Hz, 2H); ESMS (M+H+) = 328.34. This compound was used as is without r purification.

As shown in step 3—v of Scheme 3, to solution of N1—(7—morpholinoquinoxalin- -yl)cyclohexane-1,4-diamine (25 mg, 0.07 mmol) and diisopropylethylamine (18.0 mg, 24.3 11L, 0.14 mmol) in dichloromethane (750 11L) was added ethyl chloroformate (11.4 mg, 10.0 11L, 0.105 mmol). The reaction mixture was stirred for 12 hours, diluted with dichloromethane (10mL), washed with saturated s sodium bicarbonate (5mL), dried over sodium sulfate, and concentrated under reduced pressure. The resulting residue was purified by HPLC preparative chromatography using a 10-90% acetonitrile/water (0.1% TFA) gradient as eluant to provide ethyl (4-((7-morpholinoquinoxalin yl)amino)cyclohexyl)carbamate (compound 6, 14 mg, 50% yield): 1H—NMR (3 00 MHz, CDCl3) 8 8.65 (d, J = 2.0 Hz, 1H), 8.36 (d, J = 2.0 Hz, 1H), 6.61 (d, J = 2.4 Hz, 1H), 6.35 (d, J = 2.4 Hz, 1H), 6.10 (d, J = 7.6 Hz, 1H), 4.72 (s, 1H), 4.12 (q, J = 7.0 Hz, 2H), 3.96— 3.82 (m, 4H), 3.68 (s, 2H), 3.42—3.23 (m, 4H), 1.93—1.78 (m, 6H), 1.69 (dd, J = 15.0, 6.3 Hz, 2H), 1.25 (t, J = 7.1 Hz, 3H); ESMS (M+H+) = 400.17.

] As shown in step 3—vi of Scheme 3, A e of N1—(7—morpholinoquinoxalin- -yl)cyclohexane—1,4-diamine (185 mg, 0.56 mmol), 2—bromopyrimidine (93 mg, 0.58 mmol), and triethylamine (143 mg, 197 11L, 1.41 mmol) in 1-methylpyrrolidinone (3 mL) was heated to 130°C and stirred for 15 hours. After cooling to room ature, the mixture was diluted with ethyl acetate (70 mL) and methyl tert-butyl ether (20 mL), washed with water (3 x 20 mL), washed with brine (15 mL), dried over sodium sulfate, concentrated under reduced pressure, and purified by medium pressure silica gel tography (10 to 100% EtOAc/hexanes gradient) to provide Nl—(7— morpholinoquinoxalinyl)-N4-(pyrimidinyl)cyclohexane-1,4-diamine und 18, 102 mg, 45% yield): 1H—NMR (300 MHz, CDCl3) 8 8.65 (d, J = 2.0 Hz, 1H), 8.37 (d, J = 2.0 Hz, 1H), 8.27 (d, J = 4.8 Hz, 2H), 6.60(d, J = 2.4 Hz, 1H), 6.51 (t, J = 4.8 Hz, 1H), 6.36 (d, J =2.4 Hz, 1H), 6.15 (d, J = 7.8 Hz, 1H), 5.20 (d, J = 7.7 Hz, 1H), 4.04 (d, J = 7.9 Hz, 1H), 3.96—3.82 (m, 4H), 3.70 (s, 1H), 3.39—3.24 (m, 4H), 1.94 (dd, J = 13.7, 4.4 Hz, 6H), 1.78 (dt, J = 28.8, 16.1 Hz, 2H); ESMS (M+H+) = 328.34. e 4. Preparation of 1-(4-((7-(8-oxa—3-azabicyclo[3.2.1]octanyl)quinoxalin yl)amino)cyclohexyl)—3—ethylurea (Compound 22)\ MN @N Br NI/m/ / N B r / N BOC\N —> H—>BocN NMP, 180°C N Pd2(dba)3, rac—BINAP F (step 4-i) (332003 toluene 100°C [1007] 0 0 (step 4- ii) TFA/DCM _> HzNN’O’NN # (step 4—iii) *TFA DIEA DCM HN/gMOI-I: (step 4-iv) E29 kc: [22] 0 Scheme 4 As shown in step 4—i of Scheme 4, to a on of o—7— fluoroquinoxaline (compound 1002, 150 mg, 0.66 mmol) in NMP (2.3 mL) was added 8— oxaazabicyclo[3.2.1]octane (178 mg, 1.2 mmol) at RT. The reaction e was sealed in a microwave vial and heated at 180°C for 20 s. Afte cooling to RT and pouring into water, the aqueous phase was extracted with EtOAc (3x). The combined extracts were dried over MgSO4, filtered, concentrated under reduced pressure, and purified by medium pressure silica gel chromatography (0 to 100% EtOAc/hexanes gradient) to e 3-(8-bromoquinoxalinyl)—8-oxaazabicyclo[3.2.1]octane (compound 1006, 87 mg, 41% yield) as a dark orange oil: ESMS (M+H+) = 320.07.

As shown in step 4—ii of Scheme 4, a degassed solution of 3—(8— bromoquinoxalinyl)oxa—3-azabicyclo[3.2.1]octane (261 mg, 0.815 mmol), tert—butyl N—(4-aminocyclohexyl)carbamate (210 mg, 0.98 mmol), rac-BINAP (102 mg, 0.163 mmol), CszCO3 (797 mg, 2.45mmol), and Pd2(dba)3 (75 mg, 0.0815 mmol) in toluene (10.5 mL) was heated at 100°C (oil bath temp) in a sealed microwave tube for 15 hours.

After cooling, the mixture was applied directly to a chromatography column and purified by medium pressure silica gel chromatography (0 to 100% EtOAc/hexanes gradient) to afford tert—butyl (4—((7-(8-oxaazabicyclo[3 .2. 1]octan-3 -yl)quinoxalin yl)amino)cyclohexyl)carbamate (compound 1007, 141 mg, 36% yield) as a white solid: 1H—NMR (400 MHz, CDCl3) d 8.49 (s, 1H), 8.23 (d, J = 1.5 Hz, 1H), 6.48 (s, 1H), 6.18 (d, J = 1.9 Hz, 1H), 6.06 (s, 1H), 4.52 (s, 1H), 4.47 (s, 2H), 3.60 (s, 2H), 3.45 (d, J = 11.6 Hz, 2H), .12 (m, 2H), 1.96—1.84 (m, 4H), 1.79 (s, 5H), 1.54 (s, 3H) and 1.38 (s, 9H) ppm; ESMS (M+H+) = 453.96.

As shown in step 4-iii of Scheme 4, to a solution of compound 1007 (141 mg, 0.295 mmol) in CHzClz (2.5 mL) was added TFA (656 mg, 443 uL, 5.75 mmol) at RT.

The resulting black solution was stirred for 2 hours and then the reaction was quenched by the addition of saturated NaHCO3 until the black color gradually turned into an orange color. The reaction mixture was extracted with CH2Clz (3x) and the combined organic extracts were dried over NaZSO4 and evaporated to dryness to provide Nl—(7—(8—oxa—3— azabicyclo [3 .2. 1]octan-3 inoxalinyl)cyclohexane-1,4-diamine, oroacetate (compound 1008): ESMS (M+H+) = . This material was used in subsequent reactions without any further purification.

As shown in step 4—iV of Scheme 4, to a solution of compound 1008 (45 mg, 0.071 mmol) and DIEA (36.5 mg, 49.0 uL, 0.28 mmol) in CH2Clz (1.4 mL) was added ethyl isocyanate (20 mg, 0.28 mmol) at RT. The solution was stirred at this temperature for 15 hours and then d directly to a chromatography column and purified by medium re silica gel chromatograph (0 to 100% hexanes gradient) to afford 1-(4-((7-(8-oxa-3 -azabicyclo[3.2.1]octan-3 -yl)quinoxalin-5 -yl)amino)cyclohexyl)-3 - ethylurea (compound 22, 8 mg, 27% yield) as a white solid: 1H-NMR (400 MHz, CDCl3) 8 8.54 (s, 1H), 8.22 (s, 1H), 6.43 (s, 1H), 6.19 (s, 1H), 6.02 (s, 1H), 4.47 (s, 2H), 4.38 (d, J = 5.2 Hz, 1H), 4.28 (s, 1H), 3.74 (s, 1H), 3.60 (s, 1H), 3.42 (s, 4H), 3.14—3.09 (m, 4H), 2.05—1.87 (m, 3H), 1.79 (s, 3H), 1.55 (d, J = 7.1 Hz, 2H) and 1.21-1.05 (m, 5H) ppm; ESMS (M+H+) = 425.35.

Example 5. Preparation of N1-(6-morpholinobenzo[c][1,2,5]oxadiazolyl)-N4- (pyrimidinyl)cyclohexane-1,4-diamine (CompoundH 23) NBoc NHZ )0: TEA DMF 4M HCI/THF —> —> J'V| / * HCI (step 5-11)-- N NAN 140°C (step5-i) v [1010] v [1011] F5: H I’N *HCI VI [1011] HNU 00 N N Pd2(dba)3, rac—BINAP, v E j , toluene, 100°C “012] (step 5-iii) [23] Scheme 5 As shown in step 5—i of Scheme 5, a mixture of tert—butyl ((cis)—4— aminocyclohexyl)carbamate (compound 1009, 490 mg, 2.3 mmol), ropyrimidine (262 mg, 2.3 mmol) and TEA (463 mg, 63 70L, 4.6 mmol) in DMF (10 mL) was subjected to microwave irradiation for 20 minutes at 150°C. The reaction mixture was diluted with EtOAc, washed with H20, dried over NazSO4, concentrated under reduced re, and purified by medium pressure silica gel chromatography (0 to 50 % EtOAc/hexanes gradient) to provide tert-butyl (pyrimidinylamino)cyclohexyl)carbamate (compound 1010) as a white solid: 1H—NMR (300 MHz, CDC13) 8 8.28 (d, J = 4.8 Hz, 2H), 6.53 (t, J= 4.8 Hz, 1H), 5.12 (s, 1H), 4.56 (s, 1H), 3.99 (dq, J= 7.0, 3.5 Hz, 1H), 3.65 (s, 1H), 1.83 (tq, J= 10.2, 3.6 Hz, 5H), 1.66 (s, 8H), 8.13—7.91 (m, 3H), 1.47 (s, 9H).

As shown in step 5—ii of Scheme 5, HCl (3 mL, 4M in THF, 12 mmol) was added to compound 1010. The mixture was stirred for 30 min and concentrated under reduced pressure to produce N1—(pyrimidin—2—yl)cyclohexane-1,4-diamine hydrochloride (compound 1011). This material was used in subsequent reactions as is without further purification.

As shown in step 5—iii of Scheme 5, a mixture of 4-bromo morpholinobenzo[c][1,2,5]oxadiazole und 1012, 147 mg, 0.5 mmol), (cis)—N1— (pyrimidinyl)cyclohexane-l,4-diamine hydrochloride (120 mg, 0.6 mmol), (me)— BINAP (32 mg, 0.05 mmol) 0.026 mmol), and cesium carbonate (506 , a)3 (24 mg, mg, 1.55 mmol) in toluene (5 mL) was flushed with nitrogen gas and stirred overnight at 90°C under an atmosphere of nitrogen. The mixture was filtered though a layer of diatomaceous earth, concentrated under reduced pressure, and purified by medium pressure silica gel chromatography (0 to 80% EtOAc/hexanes gradient) to provide (cis)— N1—(6—morpholinobenzo[c] [ l ,2,5]oxadiazolyl)-N4-(pyrimidinyl)cyclohexane- l ,4- diamine (compound 23) as an orange solid: 1H—NMR (300 MHz, CDCl3) 5 8.20 (d, J = 4.9 Hz, 2H), 6.46 (t, J = 4.8 Hz, 1H), 6.05 (d, J = 1.6 Hz, 1H), 5.82 (s, 1H), 5.24 (s, 1H), 4.82 (d, J = 7.0 Hz, 1H), 3.98 (s, 1H), .72 (m, 4H), 3.60 (s, 1H), 3.23-3.06 (m, 4H), 1.95— 1.62 (m, 8H).

Example 6. Preparation of 5-meth0xy-N-((cis)((7-m0rpholin0quin0xalin yl)0xy)cyclohexyl)pyrimidinamine (Compound 134) _\\“OH “(\OMS “10H MsCI, TEA, i 1 N / N Et3N, iPrOH HN0 DCM HN(O + ' —’ \ A -- H2N A (step 6—i) N/ N (Step ‘3'") N/ N Br V I \ [1014] Br H B \ NH2 NH2 NH2 tr' H HO NI/er1 HO NO 2 HO NH O / HO N02 Br2 2 2 Raney Ni O —> —> —> dioxane EtOAc MeOH Br (ste 6-iii ) Br p (step6lv)_' (steP 6—v)

[1016] [1017] TBDMS-CI, | /N H c (N 1. 3 ‘Si’0 /N imidazole, E 1 O N[1014] DCM H3C7( 1 HN —> —> WH3C CH3 Pd2(dba)3, rac—BINAP, C32CO3 NAN N Br C32CO3, toluene, | E 1 dioxane, \ 100°C [:1 105°C o 2. TBAF (step 6-Viii) MeOH, /\(step 6-vii) (AIIyIPdC|)2, U / N e 100°C (step 6-ix) NAN V UN00 O\ [1341 Scheme 6 As shown in step 6—i of Scheme 6, to a e of 5-bromofluoro-pyrimidine (l g, 5.651 mmol) in iPrOH (10 mL) was added TEA (1.143 g, 1.574 mL, 11.30 mmol) and transamin0cyclohexan-l-ol (650.8 mg, 5.651 mmol). The mixture was microwaved for 20min at 150°C, concentrated under reduced pressure, diluted with EtOAc washed with water, and dried over NaZSO4. After removal of the volatiles under reduced pressure, the residue was d by medium pressure silica gel chromatography (0—80% EtOAc/hexanes gradient) to provide (trans)—4—((5 —bromopyrimidin—2— WO 59690 yl)amino)cyclohexanol (compound 1013, 1.2 g): 1H—NMR (300 MHz, CDCl3) 8 8.28 (s, 2H), 5.03 (d, J = 8.1 Hz, 1H), 3.91—3.49 (m, 2H), 2.31—1.90 (m, 4H), 1.56—1.19 (m, 4H)..

As shown in step 6—ii of Scheme 6, to compound 1013 (1.2 g, 4.41 mmol) in DCM (20 mL) was added TEA (1.134 g, 1.84 mL, 13.2 mmol) and MsCl (505 mg, 341 uL, 4.41 mmol). The reaction mixture was stirred for 1 hour, concentrated under reduced pressure, and purified by medium pressure silica gel chromatography (0 to 80% EtOAc/hexanes gradient) to e trans((5-bromopyrimidinyl)amino)cyclohexyl methanesulfonate (compound 1014): 1H—NMR (300 MHz, CDCl3) 8 8.29 (s, 2H), 5.03 (d, J = 7.8 Hz, 1H), 4.70 (tt, J = 10.6, 3.9 Hz, 1H), 3.80 (dtt, J = 11.2, 7.6, 3.7 Hz, 1H), 3.04 (s, 3H), 2.30-2.12 (m, 4H), 1.93—1.69 (m, 2H), 1.51—1.33 (m, 2H).

As shown in step 6—iii of Scheme 6, to a solution of 2-aminonitrophenol (5.00 g, 32.4 mmol) in dioxane (50 mL) was added bromine (6.22 g, 2.01 mL, 38.9 mmol).

The mixture was stirred for 2 hours and a precipitate formed, which was collected and washed with dioxane and ether. The resulting yellow solid treated with a saturated NaHCO3 solution, which was extracted with EtOAc (3x). The combined organics were dried over , filtered, and trated under reduced pressure to yield 2—amino—5— bromo—3—nitrophenol (compound 1015) as a brown solid. This material was carried on as is in subsequent reactions without futher purification.

As shown in step 6—iv of Scheme 6, to a solution of 2—aminobromo-3— nitrophenol (7.5 g, 31.8 mmol) in ethyl acetate (60 mL) was added Raney nickelTM (1.90 g, 214 ”L, 32.4 mmol) and the reaction e was shaken for 2 hours under an atmosphere of H2 at 30 psi. After filtering and drying over NaZSO4, the mixture was concentrated under reduced pressure to provide 2,3—diamino—5—bromophenol (compound 1016), which was used as is in subsequent reactions without futher purification.

As shown in step 6—v of Scheme 6, 2,3—diamino—5—bromophenol (6.0 g, 29.5 mmol) was dissolved in methanol and to this solution was added glyoxal (3.77 g, 2.98 mL, 64.9 mmol) and d ght. The reaction mixture was concentrated under reduced pressure to a minimum volume and the resulting tan solid collected by filtration and dried under high vacuum to produce 7—bromoquinoxalin—5—ol (compound 1017), which was used as is in uent ons without futher purification.

As shown in step 6—vi of Scheme 6, a solution of 7—bromoquinoxalin—5—ol (2.0 g, 8.89 mmol) in DCM (20 mL) was added imidazole (1.82 g, 26.7 mmol) and tert— butyldimethylsilyl chloride (1.34 g, 1.65 mL, 8.89 mmol). The reaction mixture was stirred overnight at RT, concentrated under reduced pressure, and purified by medium pressure silica gel tography (0 to 20% EtOAc/hexanes gradient) to e 7— bromo—5—((tert—butyldimethylsilyl)oxy)quinoxaline (compound 1018) as a colorless oil: 1H—NMR (300 MHz, CDCL3) 8 8.69 (q, J = 1.8 Hz, 2H), 7.80 (d, J = 2.1 Hz, 1H), 7.22 (d, J = 2.1 Hz, 1H), 0.96 (s, 9H), 0.81 (s, 7H).

As shown in step 6—vii of Scheme 6, a mixture of 7—bromo—5—((tert— butyldimethylsilyl)oxy)quinoxaline (700 mg, 2.06 mmol), line (270 mg, 270 ”L, 3.09 mmol), a)3 (94.50 mg, 0.1032 mmol), (rac)—BINAP (129 mg, 0.206 mmol), cesium carbonate (2.02 g, 6.19 mmol) in toluene (7 mL) was flushed with nitrogen for 10 minutes. The mixture was then heated overnight at 100°C. After cooling, the reaction mixture was diluted with EtOAc, filtered through a layer of diatomaceous earth, concentrated under reduced pressure, and purified by medium pressure silica gel chromatography (0 to 30% EtOAc/hexanes gradient) to provide 7-morpholinoquinoxalin- —01. This compound (450 mg, 1.3 mmol) was dissolved in THF (20 mL) and tetra—n- mmonium fluoride (539 mg, 2.06 mmol) was added. The reaction mixture was stirred for 0.5 hour, concentrated under reduced pressure, and purified by medium pressure silica gel chromatography (0 to 100% EtOAc /hexanes gradient) to e 7— linoquinoxalinol (compound 1019) as a yellow solid: 1H—NMR (300 MHz, CDC13) 8 8.75 (d, J = 2.0 Hz, 1H), 8.46 (d, J = 2.0 Hz, 1H), 7.70 (d, J = 41.8 Hz, 1H), 7.01 (d, J = 2.6 Hz, 1H), 6.89 (d, J = 2.5 Hz, 1H), 4.12—3.78 (m, 4H), 3.51—3.24 (m, 4H).

As shown in step 6-viii of Scheme 6, a solution of 7-morpholinoquinoxalin 01 (100 mg, 0.432 mmol), (trans)((5-bromopyrimidinyl)amino)cyclohexyl methanesulfonate (compound 1014, 303 mg, 0.865 mmol), and CsCO3 (282 mg, 0.865 mmol) in dioxane (1.0 mL was d for 16 hours at 105°C. After cooling, the reaction mixture was diluted with EtOAc, filtered through diatomaceous earth, concentrated under reduced pressure, and purified by medium pressure silica gel tography (0 to 5% MeOH/DCM gradient) to produce 5—bromo—N—((cis)—4—((7—morpholinoquinoxalin—5— yl)oxy)cyclohexyl)pyrimidinamine (compound 1020, 110 mg) as a yellow foam: 1H- NMR (400 MHz, CDC13) 8 8.70 (d, J = 2.0 Hz, 1H), 8.64 (d, J = 1.9 Hz, 1H), 8.29 (s, 2H), 6.98 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 5.29 (d, J = 8.3 Hz, 1H), 4.81 (s, 1H), 4.04-3.84 (m, 4H), 3.42—3.31 (m, 4H), 2.22 (s, 2H), 1.92 (d, J = 4.9 Hz, 6H).

As shown in step 6-ix of Scheme 6, to a mixture 5—bromo—N—((cis)—4—((7— linoquinoxalinyl)oxy)cyclohexyl)pyrimidinamine (75 mg, 0.155 mmol), cesium carbonate (101 mg, 0.309 mmol) chloride dimer (0.28 mg, , allylpalladium(H) 0.0015 mmol) RockPhos (2.17 mg, 0.0046 mmol) and MeOH (9.9 mg, 12.5 uL, 0.31 mmol) in toluene (2 mL) was flushed with nitrogen gas and heated to 100°C for 18 hours.

The reaction mixture was iluted with EtOAc, d though a layer of diatomaceous earth, and concentrated under reduced pressure. Purification by medium pressure silica gel chromatography (0—8% MeOH/DCM gradient) yielded 5—methoxy—N—((cis)—4—((7— morpholinoquinoxalinyl)oxy)cyclohexyl)pyrimidinamine (compound 134, 43 mg): 1H—NMR (300 MHz, CDCl3) 8 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 8.07 (s, 2H), 6.96 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 5.01 (d, J = 8.1 Hz, 1H), 4.80 (q, J = 5.6, 4.2 Hz, 1H), 4.03—3.87 (m, 5H), 3.80 (s, 3H), 3.42—3.27 (m, 4H), 2.29—2.10 (m, 2H), 1.99—1.82 (m, 6H).

Example 7. ation of 4-(8-(((trans)—4-(pyrimidin yloxy)cyclohexyl)oxy)quinoxalinyl)morpholine (Compound 34) and ((cis)—4— (pyrimidinyloxy)cyclohexyl)oxy)-quinoxalinyl)morpholine und 42) NélN HOUQX 00H MCI, TEA, 1. 6M HCI (aq) SDCM NaH, DMF /i/Oi}2_ NaBH4 MeOH k (step7— iii) (step 7--i) N N N / N (step 7_ ii) U [1022] U [1023] UOMS Q O —> O\\“O, NAN C82003, dioxane,110°C NJ\|N N21,“ K) (step 7—iv) V [N] ENj O V

[42] Scheme7 As shown in step 7—i of Scheme 7, to a solution of 1,4—dioxaspiro[4.5]decan—8— 01 (compound 1021, 1.0 g, 6.32 mmol) in DMF (10 mL) was added NaH (370 mg, 9.25 mmol). The reaction mixture was stirred for 20 minutes before the addition of 2- 2014/024767 chloropyrimidine (869 mg, 7.59 mmol). The mixture was d for 30 minute at RT and then heated to 100°C for 9 hours. After cooling, the mixture was diluted with EtOAc, washed with H20, dried over NazSO4, concentrated under reduced pressure, and purified by medium pressure silica gel chromatography (0—40% EtOAc/hexanes) to produce 2—(1,4— dioxaspiro[4.5]decanyloxy)pyrimidine (compound 1022) as a colorless oil: 1H NMR (300 MHz, Chloroform-d) 8 8.52 (d, J = 4.8 Hz, 2H), 6.92 (t, J = 4.8 Hz, 1H), 5.15 (ddd, J = 10.7, 6.5, 4.2 Hz, 1H), 4.05-3.87 (m, 4H), 2.14-1.85 (m, 6H), 1.79-1.65 (m, 2H); ESMS (M+H+) = 237.12.

As shown in step 7—ii of Scheme 7, to 2—(1,4—dioxaspiro[4.5]decan—8— pyrimidine (620 mg, 2.624 mmol) was added HCl (4.0 mL of 6 M, 8.86 mmol) and the reaction mixture was stirred for 2 hours. The pH of the mixture was neutralized with with sat. NaHCO3(aq) and the mixture was concentrated under reduced pressure as a ol azeotrope. To the residue was added DCM (30mL) to produce a precipitate, ed by stirring for an additional 20 minutes. The solids were filtered off and the mother liquor was concentrated under reduced pressure. The ing residue was dissolved in methanol and sodium borohydride (151 mg, 3.99 mmol) was added as a solid.

The mixture was stirred for 1 hour and the reaction quenched with HCl (6M, 0.70 mL).

Stirring was continued until gas evolution . The pH of the mixture was adjusted to about 8 with 1N sodium ide and extracted with EtOAc (20mL). The organics were dried over sodium sulfate and concentrated under d pressure to produce 4— (pyrimidinyloxy)cyclohexanol (compound 1023, 248mg, 64% yield) as a mixture of (cis)— and (trans)— isomers. A 12 mg aliquot of the sample was purified Via HPLC ative reversed—phase chromatography (IO—90% CH3CN/water nt containing 0.1% TFA) to separate the isomers: (trans)pyrimidinyloxycyclohexanol - 1H NMR (300 MHz, Chloroform-d) 8 8.54 (d, J = 4.8 Hz, 2H), 6.95 (t, J = 4.8 Hz, 1H), 5.05 (tt, J = 9.4, 4.0 Hz, 1H), 3.91-3.75 (m, 1H), 2.26-1.99 (m, 4H), 1.76-1.41 (m, 4H); ESMS (M+H+) = 195.07, (cis)—4—pyrimidinyloxycyclohexanol -1H NMR (300 MHz, Chloroform-d) 5 8.62 (d, J = 4.9 Hz, 2H), 7.04 (t, J = 4.9 Hz, 1H), 5.21 (tt, J = 5.3, 2.6 Hz, 1H), 4.56 (s, 1H), 3.85 (p, J = 5.9 Hz, 1H), 2.17—2.02 (m, 2H), 1.88-1.67 (m, 6H); ESMS (M+H+) = 195.07. The remaining material was used in subsequent reactions as the cis/trans mixture.

As shown in step 7—iii of Scheme 7, to a solution of a cis/trans mixture of 4— pyrimidinyloxycyclohexanol (244 mg, 1.256 mmol) and triethylamine (350 ”L, 2.51 mmol) in dichloromethane (5 mL) was added methane sulfonyl de (145 11L, 1.87 mmol). The reaction mixture was stirred for 2 hours, concentrated under reduced pressure, and purified by medium pressure silica gel tography (0— 20% EtOAc/dichloromethane gradient) to provide 4-pyrimidinyloxycyclohexyl) esulfonate (compound 1024, 239 mg, 70% yield) as a mixture of ans isomers: 1H NMR (300 MHz, Chloroform—d) 8 8.51 (d, J = 4.8 Hz, 2H), 6.93 (t, J = 4.8 Hz, 1H), .13 (dq, J = 9.9, 3.0 Hz, 1H), 4.87 (p, J = 3.8 Hz, 1H), 3.04 (d, J = 2.4 Hz, 3H), .99 (m, 4H), 1.99—1.74 (m, 4H); ESMS (M+H+) = 273.52.

As shown in step 7—iv of Scheme 7, a mixture of (4-pyrimidin—2— yloxycyclohexyl) methanesulfonate (105 mg, 0.386 mmol), 7-morpholinoquinoxalinol (178.3 mg, 0.7712 mmol), and CszCO3 (125.6 mg, 0.3856 mmol) in dioxane (1.5 mL) was sealed in a 5 mL microwave tube and heated to 110°C for 14 hours using an oil bath. The reaction mixture was cooled to room temperature, diluted with EtOAc, and filtered h diatomaceous earth which was subsequently washed with ethyl acetate. The filtrate was concentrated under reduced pressure and the residue purified via preparative reversed—phase HPLC (10—90% water gradient containing 0.1% TFA). Fractions containing a mixture of cis and trans isomers were further purified via SFC using a chiral OJ column and eluting with 40% MeOH in C02 to provide 21mg of 4—(8—(((trans)—4— (pyrimidinyloxy)cyclohexyl)oxy)quinoxalinyl)morpholine (compound 34): 1H NMR (300 MHz, Chloroform—d) 8 8.69 (dd, J = 3.4, 1.9 Hz, 1H), 8.62 (dd, J = 3.6, 1.9 Hz, 1H), 8.51 (dd, J = 4.8, 2.2 Hz, 2H), 7.01—6.83 (m, 3H), 5.18 (tt, J = 7.0, 3.4 Hz, 1H), 4.79 (tt, J = 6.9, 3.1 Hz, 1H), .85 (m, 4H), 3.34 (dq, J = 4.8, 2.6 Hz, 4H), 2.44-2.16 (m, 4H), 1.92 (tdd, J = 16.4, 7.7, 2.8 Hz, 4H); ESMS (M+H+) = 408.56, and 22 mg of 4—(8—(((cis)—4— (pyrimidinyloxy)cyclohexyl)oxy)-quinoxalinyl)morpholine (compound 42): 1H NMR (300 MHz, Chloroform—d) 8 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 8.52 (d, J = 4.8 Hz, 2H), 7.01—6.87 (m, 3H), 5.17 (ddt, J = 8.7, 6.7, 3.4 Hz, 1H), 4.76-4.58 (m, 1H), 4.00—3.87 (m, 4H), 3.40-3.27 (m, 4H), 2.43—2.22 (m, 4H), 2.05-1.87 (m, 2H), 1.86— 1.71 (m, 2H); ESMS (M+H+) = 408.56.

Example 8. N—[(cis)—4-[7-(3,6-dihydro-2H—pyranyl)quinoxalin yl]oxycyclohexyl]pyrimidinamine (Compound 36) H30 CH3 \\OMS O‘B’ NN N/fil/fi N/fi\l/fi [1026] | /\©N /N HO /N NJ\IN (0,0 \ [1014] HN HN NJ\|N —> Br 08003,CH30N Pd(dppf)C|2 O V NAIN(60/ 90 C [1025] rowave V (step 8-i) 150 C [36] (step 8-ii) Scheme 8 As shown in step 8—i of Scheme 8, to a mixture of 7—bromoquinoxalin—5—ol (compound 1018, 200 mg, 0.89 mmol) and cesium carbonate (579 mg, 1.78 mmol) in NMP (4.0 mL) was added (trans)(pyrimidinylamino)cyclohexyl methanesulfonate (compound 1014, 241.1 mg, 0.8887 mmol). The mixture was stirred for 18 hours at 90°C, at which time an onal 0.5 eq of compound 1014 (241 mg, 0.89 mmol) was added.

After stirring at 90°C for an additional 6 hours, the reaction mixture was diluted with EtOAc, washed with H20, dried over NazSO4, concentrated, and purified by medium pressure silica gel chromatography (0—5% MeOH/DCM) to provide s)—4—((7— bromoquinoxalinyl)oxy)cyclohexyl)pyrimidinamine und 1025): 1H-NMR (300 MHz, CDCl3) 8 9.01-8.77 (m, 2H), 8.29 (d, J = 4.8 Hz, 2H), 7.89 (d, J = 1.9 Hz, 1H), 7.25 (d, J = 2.0 Hz, 1H), 6.53 (t, J = 4.8 Hz, 1H), 5.43-5.22 (m, 1H), 4.79 (td, J = 5.2, 2.5 Hz, 1H), 4.18—3.95 (m, 1H), 3.51 (s, 1H), 2.22 (td, J = 10.2, 9.6, 5.4 Hz, 2H), .86 (m, 6H).

As shown in step 8—ii of Scheme 8, a mixture of N—((cis)—4—((7— bromoquinoxalinyl)oxy)cyclohexyl)pyrimidinamine (compound 1025, 52 mg, 0.1299 mmol) 0.01299 mmol), 2-(3,6-dihydro-2H—pyranyl)- , Pd(dppf)Clz (10.61 mg, 4,4,5,5—tetramethyl—l,3,2—dioxaborolane (compound 1026, 27.3 mg, 0.13 mmol) , NazCO3 (l95 uL of 2M (aq) solution, 0.39 mmol) in DMF (1 mL) was flushed with nitrogen gas for 10 minutes. The mixture was subjected to microwave radiation for 20 min at 150 0C.

After cooling, the mixture was diluted with EtOAc washed with H20, dried over NazSO4, concentrated under reduced re and purified by medium pressure silica gel chromatography (0—5% MeOH/DCM) to provide N—[(cis)—4—[7—(3,6—dihydro—2H—pyran—4— yl)quinoxalinyl]oxycyclohexyl]pyrimidinamine (compound 36) as an off-white solid: 1H—NMR (300 MHz, CDCl3) 5 8.94—8.76 (m, 2H), 8.29 (d, J = 4.8 Hz, 2H), 7.67 (d, J = 1.7 Hz, 1H), 6.53 (t, J = 4.8 Hz, 1H), 6.37 (tt, J = 31,15 Hz, 1H), 5.30 (d, J = 7.9 Hz, 1H), 4.87 (dt, J = 7.5, 3.6 Hz, 1H), 4.43 (q, J = 2.8 Hz, 2H), 4.02 (t, J = 5.5 Hz, 3H), 2.68 (dqd, J = 6.0, 3.4, 3.0, 1.8 Hz, 2H), 2.35—2.11 (m, 2H), 2.07—1.84 (m, 6H); ESMS (M+H+) = 404.2.

Example 9. N—((cis)—4-((7-morpholinoquinoxalinyl)oxy)cyclohexyl)pyrimidinamine (Compound 28) HO\¢¢N H N/\ N N \ “19—“[1017] ago /N [0j ()1 Cgizo PPh3, DIAD, AP {£1230 THF, 0°c to RT Br a)3 110°C (step 9—-i) [1°23] (step 9-ii) [1029] [0N] 0 NI H2NNH2 / N / N H3 M90” RT DIEA, 100°C (step 9—iii)H (step 9—iv) N / IN [28] V [N] Scheme 9 As shown in step 9—i of Scheme 9, 7—bromoquinoxalin—5—ol (compound 1017, .4 g, 24.0 mmol), 2—((trans)—4—hydroxycyclohexyl)isoindoline—1,3—dione (5.607 g, 22.86 mmol), and triphenylphosphine (8.994 g, 7.945 mL, 34.29 mmol) were dissolved in anhydrous THF and the flask was cooled in an ice bath. DIAD (6.93 g, 6.64 mL, 34.3 mmol) was added dropwise and the reaction was stirred at 0°C for 5 minutes, then warmed to room temperature and stirred for 18 hours. The reaction mixture was concentrated under reduced pressure, the e was treated with EtZO and stirred for 0.5 hour at RT, the precipitates filtered off, the e concentrated under reduced pressure, and the residue purified by medium pressure silica gel chromatography (0—50% EtOAc/hexanes gradient) to produce 2—[(cis)—4—(7—bromoquinoxalinyl)oxycyclohexyl]isoindoline—1,3- dione (compound 1028, 6.2 g, 60% yield): 1H—NMR (300 MHz, CDCl3) 8 8.95 (d, J = 1.8 Hz, 1H), 8.86 (d, J = 1.8 Hz, 1H), 7.91 (d, J = 2.0 Hz, 1H), .80 (m, 2H), 7.77—7.68 (m, 2H), 7.31 (d, J = 2.0 Hz, 1H), 4.96 (t, J = 2.9 Hz, 1H), 4.29 (tt, J = 12.5, 3.8 Hz, 1H), 2.88 (qd, J = 12.9, 3.6 Hz, 2H), 2.54—2.32 (m, 2H), 1.94—1.61 (m, 4H).

] As shown in step 9—ii of Scheme 9, In a round bottom flask fitted with a condenser, a mixture of 2-[4-(7-bromoquinoxalinyl)oxycyclohexyl]isoindoline-1,3- dione (6.2 g, 12.34 mmol) , morpholine (1.61 g, 1.62 mL, 18.5 mmol) and CszCO3 (12.06 g, 37.0 mmol) in anhydrous toluene (73 mL) was treated with rac—BINAP (768.4 mg, 1.234 mmol) and Pd2(dba)3 (565 mg, 0.617 mmol). The reaction mixture was heated at 110°C for 18 hours. After cooling to room temperature, the mixture was filtered through diatomaceous earth and concentrated under reduced re. The residue was triturated with EtZO and the solids collected by filtration and washed with EtZO to produce s)— 4—((7—morpholinoquinoxalin—5—yl)oxy)cyclohexyl)isoindoline—1,3—dione (compound 1029, 4.2 g) as yellow solid. The filterate was concentrated under reduced pressure and purified by medium pressure silica gel chromatography (0—100% hexanes gradient) to e an additional 300 mg of compound 1029: 1H—NMR (3 00 MHz, CDCl3) 8 8.76— 8.63 (m, 2H), 7.85 (dd, J = 5.4, 3.1 Hz, 2H), 7.79—7.60 (m, 2H), 7.09 (d, J = 2.6 Hz, 1H), 6.99 (d, J = 2.5 Hz, 1H), 5.06 (t, J = 2.8 Hz, 1H), 4.27 (tt, J = 12.3, 3.8 Hz, 1H), 4.02—3.85 (m, 4H), 3.49—3.27 (m, 4H), 3.03—2.75 (m, 2H), 2.37 (d, J = 14.0 Hz, 2H), 1.83-1.56 (m, 4H).

As shown in step 9—iii of Scheme 9, to a suspension of s)—4—(7— morpholinoquinoxalinyl)oxycyclohexyl]isoindoline-1,3-dione (2.3 g, 5.02 mmol) in MeOH (25 mL) was added hydrazine (321 mg, 315 ”L, 10.0 mmol) and the reaction mixture d for 18 hours at RT, over which time the initial suspension became homogenenous followed by the appearance of a precipitate. EtZO (30 mL) was added and the reaction mixture stirred an additional 30 minutes. The precipitates were filtered off, the filtrate concentrated under d pressure, the residue treated with DCM (30 mL), and any remaining solids removed by filtration. The filtrate was concentrated under reduced pressure to provide (cis)—4—((7—morpholinoquinoxalinyl)oxy)cyclohexanamine (compound 1030), which was used as is in subsequent reactions: 1H—NMR (3 00 MHz, CDCl3) 8 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 6.95 (d, J = 2.5 Hz, 1H), 6.90 WO 59690 (d, J = 2.5 Hz, 1H), 5.00—4.67 (m, 3H), 4.03—3.81 (m, 4H), 3.49 (s, 1H), 3.43—3.25 (m, 4H), 2.88 (q, J = 6.2 Hz, 2H), 2.36—1.96 (m, 6H).

As shown in step 9—iv of Scheme 9, to a solution so (cis) 4—(7— morpholinoquinoxalinyl)oxycyclohexanamine (415 mg, 1.264 mmol) and 2- methylsulfonylpyrimidine (400 mg, 2.53 mmol) was added DIEA (490 mg, 661 ”L, 3.79 mmol) and the reaction mixture was sealed in a vessel and heated to 100°C for 16 hours.

After this time, the les were removed under a stream of nitrogen gas and the crude e dissolved in minimal amount of DCM. Purification by medium pressure silica gel chromatography (0—10% MeOH/DCM, 1% Et3N] produced N—((cis)—4—((7— morpholinoquinoxalinyl)oxy)cyclohexyl)pyrimidinamine containing triethylamine hydrochloride as an impurity. Dissolved product in DCM and stirred with a silica- supported amine (Silabond amine® 40—63 ,um). The scavenger mixture was filtered, concentrated under reduced re, and dried under high vacuum to provide N—((cis)—4— ((7-morpholinoquinoxalinyl)oxy)cyclohexyl)pyrimidinamine (Compound 28, 435 mg): 1H—NMR (400 MHz, CDCl3) 8 8.68 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 8.27 (s, 1H), 8.26 (s, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 6.50 (t, J = 4.8 Hz, 1H), 4.78 (s, 1H), 4.08 — 3.97 (m, 1H), 3.94 — 3.86 (m, 4H), 3.37 — 3.28 (m, 4H), 2.20 (d, J = 9.1 Hz, 2H), 1.95 — 1.85 (m, 6H).

Example 10. Preparation of N-[4-[7-(6-oxaazabicyclo[3.1.1]heptanyl)quinoxalin yl]oxycyclohexyl]pyrimidinamine (Compound 291) O N + —’ N o 0 / 00 Br N "”'0H ,filfl: Scheme 10a To a mixture of 7-bromoquinoxalinol (47.53 g, 211.2 mmol), 2-(4- hydroxycyclohexyl)isoindoline-1,3-dione (52.41 g, 213.7 mmol), and PPh3 (87.31 g, 332.9 mmol) in THF (740 mL) at 21 0C was added tert-butyl (NZ)—N—tert— butoxycarbonyliminocarbamate ) (79.51 g, 328.0 mmol) in portions over 40 min so as to maintain the temperature below 30 OC and the resultant reaction mixture was stirred at room temperature for a further 20 h.

The reaction was evaporated in vacuo. The residual reddish—brown viscous oil was dissolved in CH2Cl2 and filtered through a plug of silica in a glass column using applied air pressure (plug was made with 1L of dry silica suspended in CH2Cl2). The plug was eluted with CH2Cl2, the fractions were ed and evaporated in vacuo to afford a red—brown viscous oil/foam, that was then dissolved in 700 mL of MeOH before precipitating. The mixture was d at room temperature for 1 h, filtered, washed with cold MeOH (500 mL) and Et2O (100 mL), then dried in vacuo to yield a tan solid that was suspended in 300 mL MeOH and brought to reflux for 10 min. The suspension was cooled to room temperature and ed, washed with a further MeOH and Et2O (4: 1), and dried in vacuo to provide 2—[4-(7-bromoquinoxalinyl)oxycyclohexyl]isoindoline-1,3-dione (58.43 g, 126.6 mmol, 59.94%). 1H NMR (400 MHz, CDCl3) 5 8.96 (d, J = 1.8 Hz, 1H), 8.86 (d, J =1.8 Hz, 1H), 7.91 (d, J = 1.9 Hz, 1H), 7.89 — 7.82 (m, 2H), 7.78 — 7.67 (m, 2H), 7.30 (d, J =1.9 Hz, 1H), 4.95 (s, 1H), 4.29 (tt, J = 12.5, 3.7 Hz, 1H), 2.87 (qd, J = 13.1, 3.5 Hz, 2H), 2.44 (d, J = 15.2 Hz, 2H), 1.80 (t, J = 14.1 Hz, 2H), 1.67 (d, 2H). EST—MS m/z calc. 316, found 452.19 (M+1)+; ion time: 0.92 minutes.

WO 59690 0 can.O N N J\ \3 Br N N N Scheme 10b ] A mixture of 2-[4-(7-bromoquinoxalinyl)oxycyclohexyl]isoindoline-1,3- dione (1 g, 2.211 mmol), 6-oxaazabicyclo[3.1.1]heptane HCl (180 mg, 1.328 mmol), cesium carbonate (2.161 g, 6.633 mmol), a)3 (202.5 mg, 0.2211 mmol) and rac— BINAP (275.3 mg, 0.4422 mmol) in dioxane (5 mL) was stirred overnight at 70 0C, then heated in a microwave reactor for 15 min at 150 °C. The reaction was then diluted with methylene chloride, filtered though Celite, and concentrated. Silica gel flash column chromatography (0-5% MeOH/DCM) yielded 2-[4-[7-(6-oxa—3-azabicyclo[3.1.1]heptan—3- yl)quinoxalin-5—yl]oxycyclohexyl]isoindoline—1,3—dione (750 mg, 72.1%) as a yellow solid that was carried on to the next reaction. 0 ””00 gm —> N\ $6,N: Scheme 10c To a solution of 2—[4—[7—(6-oxa—3—azabicyclo[3.1.1]heptan-3—yl)quinoxalin—5— yl]oxycyclohexyl]isoindoline-1,3-dione (800 mg, 1.700 mmol) in EtOH (10 mL) was added hydrazine monohydrate (85.10 mg, 83.35 uL, 1.700 mmol) and the reaction was stirred at reflux overnight, then concentrated, d with DCM, and filtered. The filtrate WO 59690 was trated, and purified on a 40 g silica gel cartridge with 0—50% (20% NH3/MeOH) to yield 4—[7—(6—oxa—3-azabicyclo[3.1.1]heptanyl)quinoxalin yl]oxycyclohexanamine (450 mg, 77.8%) as a yellow solid. 1H NMR (300 MHz, form—d) 6 8.65 (d, J = 1.9 Hz, 1H), 8.53 (d, J = 1.9 Hz, 1H), 6.83 (q, J = 2.6 Hz, 2H), 4.83 (t, J = 6.0 Hz, 4H), 3.87 = 8.7, 6.6 Hz, 1H), 3.01 — 3.60 (m, 5H), 3.34 (dt, J — 2.83 (m, 1H), 2.23 (dq, J = 11.3, 5.8, 4.8 Hz, 2H), 2.07 (d, J = 8.7 Hz, 1H), 1.92 — 1.62 (m, 6H).

H2NOH do. <1: * U —» N N<1”?N/ Scheme 10d A mixture of 4-[7-(6-oxa-3 -azabicyclo[3.1.1]heptanyl)quinoxalin yl]oxycyclohexanamine (190 mg, 0.5581 mmol), 2-fluoropyrimidine (60 mg, 0.6118 mmol) and DIEA (200 ”L, 1.148 mmol) in 2-propanol (2 mL) was heated in a microwave reactor for 20 min at 150 °C. The reaction mixture was concentrated, and then purified from 12 g silica gel cartridge with 0-6% MeOH/DCM to yield N—[4—[7—(6—oxa—3— azabicyclo[3. 1. 1]heptanyl)quinoxalinyl]oxycyclohexyl]pyrimidinamine (120.2 mg, 48.9%) as a yellow solid. Mass + 1: 419.23; Retention Time: 0.72; NMR Annotation: 1H NMR (400 MHz, Chloroform-d) 5 8.42 (d, J = 1.9 Hz, 1H), 8.30 (d, J = 1.9 Hz, 1H), 8.04 (d, J = 4.8 Hz, 2H), 6.65 — 6.56 (m, 2H), 6.28 (t, J = 4.8 Hz, 1H), 4.99 (d, J = 8.1 Hz, 1H), 4.60 (d, J = 6.5 Hz, 3H), 3.79 (dd, J = 8.2, 4.0 Hz, 0H), 3.62 — 3.38 (m, 4H), 3.17 — 3.03 (m, 1H), 2.07 — 1.90 (m, 2H), 1.89 — 1.59 (m, 7H).

Example 11. Preparation of 6-(4-methylpiperazinyl)-N—((1s,4s)((7- morpholinoquinoxalinyl)oxy)cyclohexyl)pyrimidinamine (Compound 537) H2NU N CI WN‘ NO 0 NW? NJ NaOt—Bu O fiNj t-BuXPhos Palladacycle / ENj / ~ QM] o It J , 100 °C to ~ Scheme 11 A suspension of orpholinoquinoxalin—5—yl)oxycyclohexanamine (500 mg, 1.52 mmol), 4-chloro(4-methylpiperazinyl)pyrimidine (324 mg, 1.52 mmol), and NaOt—Bu (440 mg, 4.58 mmol) in t—BuOH (10.1 mL) was degassed by bubbling N2 through the mixture for 10 min. t—BuXPhos Palladacycle (53 mg, 0.077 mmol) was added, and the on mixture was sealed hermetically and heated to 100 0C in an oil bath for 2 h. The t was removed in vacuo, and the crude residue was purified by silica gel chromatography (40 g Isco gold column, linear gradient 0% —> 10% MeOH/CH2C12 [+0. 1% Et3N]) to yield 6-(4-methylpiperazinyl)-N—((1s,4s)—4-((7- morpholinoquinoxalinyl)oxy)cyclohexyl)pyrimidinamine as a yellow solid (654.7 mg, 83.5% yield). 1H NMR (400 MHz, Chloroform—d) 8 8.69 (d, J = 1.8 Hz, 1H), 8.61 (d, J =1.8 Hz, 1H), 8.19 (s, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.3 Hz, 1H), 5.42 (s, 1H), 4.78 (s, 1H), 4.70 (d, J = 8.0 Hz, 1H), 3.97 — 3.87 (m, 4H), 3.83 (s, 1H), 3.64 — 3.50 (m, 4H), 3.40 — 3.27 (m, 4H), 2.53 = 9.2 Hz, 2H), — 2.42 (m, 4H), 2.34 (s, 3H), 2.19 (d, J 1.97 — 1.77 (m, 6H). ESI—MS m/z calc. 504.2961, found 505.44 (M+1)+; Retention time: 0.5 minutes. e 12. Preparation of 2-(4-methylpiperazinyl)-N—((1s,4s)((7- morpholinoquinoxalinyl)oxy)cyclohexyl)pyrimidinamine (Compound 535) H2N0 H Cl N N o *J UN / Eli 0 (\N N’ EtOH, reflux J OJ {\N N \N/W 2_ M2 ylpiperazine 0‘0 i-Pr2NEt i-PrOH, 170 °C uwave (\Na JN Scheme 12 To a solution of 4-(7-morpholinoquinoxalinyl)oxycyclohexanamine (500 mg, 1.522 mmol) and Et3N (212 uL, 1.522 mmol) in EtOH (7.25 mL) was added 2,4— dichloropyrimidine (216.0 mg, 1.450 mmol). The resultant reaction solution was heated to reflux for 5 h, then cooled to room temperature. The solvent was removed in vacuo, and the crude residue was purified by silica gel chromatography (40 g Isco gold column, linear gradient 0% —> 10% MeOH/CHzClz [+0.1% Et3N]) to e 2—chloro—N—[4—(7— morpholinoquinoxalinyl)oxycyclohexyl]pyrimidinamine as a yellow solid (485 mg, 75% yield). 1H NMR (300 MHz, Chloroform—d) 8 8.70 (d, J = 2.0 Hz, 1H), 8.60 (d, J = 2.0 Hz, 1H), 8.00 (d, J = 4.8 Hz, 1H), 6.96 (d, J = 2.5 Hz, 1H), 6.89 (d, J = 2.5 Hz, 1H), 6.23 (d, J = 5.9 Hz, 1H), 5.18 (d, J = 5.7 Hz, 1H), 4.80 (s, 1H), 3.99 — 3.84 (m, 4H), 3.42 — 3.21 (m, 4H), 2.32 — 2.08 (m, 2H), 2.05 — 1.73 (m, 6H). ESI—MS m/z calc. 440.17276, found 441.25 ; Retention time: 0.69 minutes.

A solution of 2—chloro-N—[4-(7-morpholinoquinoxalin yl)oxycyclohexyl]pyrimidinamine (236 mg, 0.5352 mmol), 1-methylpiperazine (190 uL, 1.711 mmol), and Hunig's base (315 uL, 1.808 mmol) in i—PrOH (3.6 mL) was heated to 170 °C in a microwave for 1 h. The solvent was removed in vacuo. The crude residue was purified by silica gel chromatography (40 g Isco gold column, linear gradient 0% —> % MeOH/CHzClz [+0.1% Et3N]) to provide 2-(4-methylpiperazinyl)-N—((1s,4s) ((7-morpholinoquinoxalinyl)oxy)cyclohexyl)pyrimidinamine as a yellow solid (219 mg, 79% yield). 1H NMR (400 MHz, Chloroforrn—d) 8 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 7.88 (d, J = 5.7 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), .67 (d, J = 5.8 Hz, 1H), 4.84 — 4.63 (m, 2H), 3.99 — 3.83 (m, 5H), 3.82 — 3.73 (m, 4H), 3.37 — 3.27 (m, 4H), 2.49 — 2.40 (m, 4H), 2.33 (s, 3H), 2.23 — 2.11 (m, 2H), 1.96 — 1.82 (m, 6H). EST—MS m/z calc. 504.2961, found 505.35 (M+1)+; Retention time: 0.51 minutes. e 13. Preparation of N—methyl(((1s,4s)((7-morpholinoquinoxalin yl)oxy)cyclohexyl)amino)pyrimidine—4—carboxamide und 359) GNU-l 1) Oxallyl de 0' DMF \ 2) methyl amine I TH NVN NV“ NaHCO3 Scheme 13a A solution of oxalyl chloride (186.2g, 256.0 mmol) and DMF (1.7 mL, 21.96 mmol) was added to a suspension of 6—chloropyrimidine—4—carboxylic acid (9.1 g, 57.40 mmol) in dichloromethane (3 00 mL) dropwise via dropping funnel over 20min. Allowed to stir for 2hr and concentrated the acid chloride under reduced pressure. The acid chloride was dissolved in dichloromethane ) and to it was added a solution of methylamine (30.71 mL of 40 %w/v, 395.5 mmol) in water and NaHCO3 (188.3 mL of 1.2 M, 226.0 mmol) dropwise. The on mixture was d to stir overnight. The layers were separated and extracted the aqueous layer with dichloromethane (200mL).

The combined organics were washed with brine, dried over sodium sulfate, and concentrated under reduced pressure. Chromatographed over 120g silica gel using 0—50% EtOAc/Heptane as eluent. 4.356g (44.94% yield) of ro—N—methylpyrimidine carboxamide was obtained as a white solid. 1H NMR (400 MHz, Chloroform—d) 5 8.99 (d, J =1.1Hz, 1H), 8.16 (d, J =1.1Hz, 1H), 7.90 (s, 1H), 3.06 (d, J = 5.2 Hz, 3H).

NH2 o’fi 0 V“ /“ O 0 sodium t—butoxide N CI i N E / \ + \ H t-BuXPhos palladacycle | 0 t—BuOH N “N N’ N N N {W W H I \ '0‘ K/o / H Scheme 13b A solution of orpholinoquinoxalinyl)oxycyclohexanamine (7.593 g, 23.12 mmol), 6-chloro-N-methyl-pyrimidinecarboxamide (4.35 g, 25.35 mmol), and t- BuXPhos palladacycle (1.519 g, 2.333 mmol) in tBuOH (100 mL) was added sodium t— butoxide (25.5 mL of 2 M, 51.00 mmol). Allowed to stir at room temperature under N2 overnight. The reaction was diluted with dichloromethane (100mL) and filtered through Celite with dichloromethane wash. The filtrate was concentrated under d pressure and chromatographed over 330g silica gel using 0—>14% Methanol/DCM as eluent. The ing product was dissolve in small amount of ethanol (15mL) and the product precipitated over 1h. Filtered with cold ethanol wash to give a yellow solid. the solid was dried under vacuum over for 48h at 50°C to yield N—methyl—6—(((1s,4s)—4—((7— morpholinoquinoxalinyl)oxy)cyclohexyl)amino)pyrimidinecarboxamide (2.58g) as a yellow solid. 1H NMR (300 MHz, form—d) 8 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 8.53 = 5.6 Hz, 1H), 7.20 (d, J = 1.2 Hz, 1H), 6.96 — 8.44 (m, 1H), 8.00 (d, J (d, J = 2.5 Hz, 1H), 6.90 (d, J = 2.5 Hz, 1H), 5.50 (s, 1H), 4.83 (dt, J = 4.8, 2.5 Hz, 1H), 3.97 = 5.1 Hz, 3H), 2.31 — 3.87 (m, 4H), 3.39 — 3.29 (m, 4H), 3.01 (d, J — 2.19 (m, 2H), 2.06 — 1.70 (m, 6H). EST—MS m/z calc. 463.2332, found 464.25 (M+1)+; Retention time: 0.59 minutes. 2014/024767 Example 14. Preparation of N—methyl(((1s,4s)((7-morpholinoquinoxalin yl)oxy)cyclohexyl)amino)pyrimidine—4—carboxamide (Compound 350) O O \ EDCI, HOBT MLNH N N gfithflamme N N Scheme 14a A solution of 2-chloropyrimidine—4-carboxylic acid (4.425 g, 27.91 mmol) in DMF (35.40 mL) was added 1-hydroxybenzotriazole (Water (1)) (2.982 g, 19.47 mmol) and EDCI (Hydrochloric Acid (1)) (6.372 g, 33.24 mmol) at room temperature. After stirred for 10 min, to the mixture was added METHYL AMINE in tetrahydrofuran(20.93 mL of 2 M, 41.86 mmol) and stirred for 2h. The reaction was diluted with ethyl acetate, washed with water, and dried over sodium sulfate then concentrated. The resuting residue was purified from silica gel column 0-30% ethyl acetate/ hexanes to obtain 2-chloro-N— methylpyrimidinecarboxamide as a white solid. 1H NMR (300 MHz, form—d) 5 8.85 (d, J = 4.9 Hz, 1H), 8.07 (d, J = 4.9 Hz, 1H), 7.82 (s, 1H), 7.27 (s, 0H), 3.06 (d, J = .2 Hz, 3H). 09 .\ / sodium t—butoxide o a”N / N 0v ‘ J\ E + N \N | N z W| hos palladacycle \ N N’W NH t—BuOH I K/O , N N’fi Scheme 14b A solution of 4-(7-morpholinoquinoxalinyl)oxycyclohexanamine (6.013 g, 18.31 mmol), ro-N-methyl-pyrimidinecarboxamide (3.41 g, 19.87 mmol) and t- BuXPhos palladacycle (1.220 g, 1.873 mmol) in tBuOH (100 mL) was added sodium t— butoxide (20.52 mL of 2 M, 41.04 mmol). Allowed to stir at rt under N2 overnight.

Diluted rxn with dichloromethane (100mL), filtered through celite and concentrated e under reduced pressure. The resulting residue was chromatographed over 220g silica gel using 0—>14% Methanol/dichlomethane. The product was ated with ethanol (40mL) at 70°C for 2h, filtered and dried under vacuum at 50°C overnight to obtain N— (((1s,4s)—4-((7-morpholinoquinoxalinyl)oxy)cyclohexyl)amino)pyrimidine carboxamide (5.03 g, 62%yield) as a fine yellow powder. 1H NMR (300 MHz, Chloroform-d) 8 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.48 (d, J = 4.9 Hz, 1H), 7.75 (s, 1H), 7.32 (d, J = 4.9 Hz, 1H), 6.96 (d, J = 2.5 Hz, 1H), 6.91 (d, J = 2.5 Hz, 1H), 5.30 (d, J = 7.9 Hz, 1H), 4.85 = 8.5, 4.7 Hz, 1H), 3.99 - 4.73 (m, 1H), 4.07 (dd, J - 3.82 (m, 4H), 3.41 = 5.1 Hz, 3H), 2.20 (q, J = 6.0 Hz, 2H), 2.06 - 3.20 (m, 4H), 3.01 (d, J - 1.82 (m, 6H). EST-MS m/z calc. 463.2332, found 464.31 (M+1)+; Retention time: 0.71 minutes Tables 1 and 2 provides analytical characterization data for certain compounds of formula I (blank cells indicate that the test was not performed).

Table 1.

H NMR (300 MHz, unless indicated otherwise) NMR oeaks iven as 8 values (CDC13) 3 8.64 (d, J = 2.0 Hz, Nfi 1H), 8.36 (d, J=2.0 Hz, 1H), N 6.61 (d, J = 2.4 Hz, 1H), 6.34 i 0’ (d, J = 2.4 Hz, 1H), 5.90 (s, N9" 370.52 1H), 5.40 (d, J = 7.7 Hz, 1H), N 3.98 — 3.76 (m, 5H), 3.51 — 3.24 E j (m, 5H), 2.33 — 2.08 (m, 4H), 0 1.99 (s, 3H), 1.58 — 1.31 (m, (CDC13) 3 8.63 (d, J = 1.9 Hz, 1H), 8.34 (d, J =19 Hz, 1H), 7.17 (d, J = 8.6 Hz, 2H), 6.90 o’ 3 Nfi (d, J = 8.5 Hz, 2H), 6.59 (d, J = N 2.2 Hz, 1H), 6.29 (d, J = 2.2 0’ Hz, 1H), 5.86 (d, J = 7.6 Hz, 476.61 1H), 5.29 (d, J = 8.0 Hz, 1H), N 3.96 — 3.75 (m, 8H), 3.52 (s, E 1 2H), 3.39 —3.22 (m, 5H), 2.19 0 (d, J: 11.7 Hz, 2H), 2.12 _ 1.89 (m, 2H), 1.43 (td, J = 13.0, 2.4 Hz, 2H), 1.32 _ 1.15 (m, H NMR (300 MHz, unless Compound Structure ted otherwise) NMR peaks given as 5 values (CDC13) 5 8.65 (d, J = 2.0 Hz, 1H), 8.35 (d, J = 2.0 Hz, 1H), 6.60 (d, J = 2.4 Hz, 1H), 6.34 (d, J = 2.4 Hz, 1H), 6.11 (d, J = 7.8 Hz, 1H), 4.60 (s, 1H), 3.97 — 3.86 (m, 4H), 3.67 (s, 2H), 3.41 = — 3.25 (m, 4H),1.85(d, J 3.0 Hz, 5H), 1.74 — 1.57 (m, 3H 1.45 , s, 9H (CDC13) 5 8.64 (d, J = 1.9 Hz, 1H), 8.34 (d, J :19 Hz, 1H), 6.61 (d, J = 2.2 Hz, 1H), 6.35 (d, J = 2.3 Hz, 1H), 6.12 (br s, 1H), 5.56 (d, J = 7.5 Hz, 1H), 4.11 — 3.81 (m, 5H), 3.70 (m, 1H), 3.42 — 3.24 (m, 4H), 1.99 (s, 3H), 1.86 (m, 6H), 1.75 — 1.51 m, 2H (CDC13) 5 8.65 (d, J = 2.0 Hz, 1H), 8.36 (d, J = 2.0 Hz, 1H), 6.62 (d, J = 2.4 Hz, 1H), 6.34 (d, J = 2.3 Hz, 1H), 6.09 (d, J = 7.6 Hz, 1H), 4.68 (d, J = 7.2 Hz, 1H), 3.97 — 3.82 (m, 4H), 3.76 — 3.47 (m, 2H), 3.40 — 3.23 (m, 4H), 3.01 (s, 3H), 2.04 — 1.65 m, 8H (CDC13) 5 8.65 (d, J = 2.0 Hz, 1H), 8.36 (d, J = 2.0 Hz, 1H), 6.61 (d, J = 2.4 Hz, 1H), 6.35 (d, J = 2.4 Hz, 1H), 6.10 (d, J = 7.6 Hz, 1H), 4.72 (s, 1H), 4.12 (q, J = 7.0 Hz, 2H), 3.96 — 3.82 (m, 4H), 3.68 (s, 2H), 3.42 — 3.23 (m, 4H), 1.93 — 1.78 (m, 6H), 1.69 (dd, J =15.0, 6.3 Hz, H NMR (300 MHz, unless nd Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 3 8.65 (d, J = 2.0 Hz, 1H), 8.35 (d, J = 2.0 Hz, 1H), 6.61 (d, J = 2.4 Hz, 1H), 6.35 (d, J = 2.3 Hz, 1H), 6.10 (d, J = 7.7 Hz, 1H), 5.26 (s, 1H), 4.85 (d, J = 7.4 Hz, 1H), 4.03 — 3.79 (m, 8H), 3.68 (s, 2H), 3.41 — 3.24 (m, 4H), 2.16 (dd, J = 13.9, 6.0 Hz, 1H), 2.08 — 1.93 (m, 1H), 1.86 (d, J = 3.5 Hz, 6H), 1.76 — 1.54 (m, 2H) (CDC13) 3 8.65 (d, J = 2.0 Hz, 1H), 8.36 (d, J = 2.0 Hz, 1H), 6.61 (d, J = 2.4 Hz, 1H), 6.35 (d, J = 2.4 Hz, 1H), 6.10 (d, J = 7.6 Hz, 1H), 4.88 (d, J = 6.3 Hz, 1H), 4.21 (d, J = 4.1 Hz, 2H), 3.95 — 3.88 (m, 4H), 3.87 — 3.59 (m, 4H), 3.40 — 3.26 (m, 4H), 1.95 — 1.52 (m, 9H) (CDC13) 3 8.65 (d, J = 1.9 Hz, 1H), 8.37 (d, J = 2.0 Hz, 1H), 6.61 (d, J = 2.3 Hz, 1H), 6.34 (d, J = 2.3 Hz, 1H), 6.09 (d, J = 7.4 Hz, 1H), 4.81 (s, 1H), 4.66 (s, 2H), 4.01 — 3.86 (m, 4H), 3.65 (s, 2H), 3.42 — 3.24 (m, 4H), 1.87 (t, J = 2.3 Hz, 5H), 1.64 d, J 26.9 Hz, 6H (CDC13) 3 8.65 (d, J = 1.9 Hz, 1H), 8.36 (d, J =19 Hz, 1H), 6.61 (d, J = 2.3 Hz, 1H), 6.35 (d, J = 2.3 Hz, 1H), 6.10 (d, J = 7.7 Hz, 1H), 4.72 (s, 1H), 4.02 (t, J = 6.6 Hz, 2H), 3.95 — 3.82 (m, 4H), 3.68 (s, 2H), 3.43 — 3.26 (m, 4H), 1.87 (d, J = 3.7 Hz, 6H), 1.78 — 1.50 (m, 4H), H NMR (300 MHz, unless Compound Structure ted otherwise) NMR peaks given as 8 values (CDC13) 3 8.65 (d, J = 2.0 Hz, 1H), 8.35 (d, J = 2.0 Hz, 1H), 6.60 (d, J = 2.4 Hz, 1H), 6.35 (d, J = 2.4 Hz, 1H), 6.10 (d, J = 7.7 Hz, 1H), 4.91 (dt, J = 12.5, 6.2 Hz, 1H), 4.69 (s, 1H), 4.01 — 3.81 (m, 4H), 3.68 (s, 2H), 3.46 — 3.24 (m, 4H), 1.93 — 1.76 (m, 6H), 1.78 — 1.56 (m, 2H), 1.25 (t, J = 9.6 Hz, 6H) (CDC13) a 8.65 (d, J = 1.9 Hz, 1H), 8.35 (d, J =19 Hz, 1H), 6.61 (d, J = 2.3 Hz, 1H), 6.35 (d, J = 2.3 Hz, 1H), 6.11 (d, J = 7.6 Hz, 1H), 4.74 (s, 1H), 3.99 — 3.79 (m, 6H), 3.68 (s, 2H), 3.40 = — 3.24 (m, 4H), 1.87 (d, J 3.5 Hz, 7H), 1.78 _ 1.52 (m, 2H), 0.93 (d, J = 6.7 Hz, 6H) (CDC13) 5 8.65 (t, J = 1.6 Hz, 1H), 8.36 (t, J = 1.6 Hz, 1H), 6.61 (d, J = 2.3 Hz, 1H), 6.35 (d, J = 2.0 Hz, 1H), 6.11 (d, J = 7.6 Hz, 1H), 4.91 (d, J = 7.2 Hz, 1H), 4.80 — 4.18 (m, 4H), 4.00 — 3.84 (m, 4H), 3.81 — 3.56 (m, 2H), 3.46 — 3.21 (m, 4H), 1.87 (d, J: 3.5 Hz,6H), 1.71 dd, J 16.0, 8.2 Hz, 2H (CDC13) 5 8.65 (d, J = 2.0 Hz, 1H), 8.36 (d, J = 2.0 Hz, 1H), 6.61 (d, J = 2.4 Hz, 1H), 6.34 (d, J = 2.3 Hz, 1H), 6.10 (d, J = 7.1 Hz, 1H), 4.83 (s, 1H), 4.69 (s, 2H), 3.96 — 3.83 (m, 4H), 3.68 (s, 2H), 3.40 — 3.23 (m, 4H), 2.48 (t, J = 2.4 Hz, 1H), 1.87 (d, J = 4.2 Hz,6H), 1.71 H NMR (300 MHz, unless Compound Structure indicated ise) NMR peaks given as 8 values (CDC13) 8 8.66 (d, J = 2.0 Hz, 1H), 8.37 (d, J = 2.0 Hz, 1H), 7.10 = — 6.98 (m, 2H), 6.87 (d, J 9.0 Hz, 2H), 6.62 (d, J = 2.4 Hz, 1H), 6.36 (d, J = 2.4 Hz, 1H), 6.13 (d, J = 7.3 Hz, 1H), .06 (d, J = 7.9 Hz, 1H), 3.97 — 3.84 (m, 4H), 3.84 — 3.61 (m, 5H), 3.42 — 3.25 (m, 4H), 1.91 (d, J = 4.2 Hz, 6H), 1.85 — 1.68 (m, 2H) (CDC13) 8 8.49 (s, 1H), 8.23 (d, J = 1.5 Hz, 1H), 6.48 (s, 1H), 6.18 (d, J = 1.9 Hz, 1H), 6.06 (s, 1H), 4.52 (s, 1H), 4.47 (s, 2H), 3.60 (s, 2H), 3.45 (d, J = 11.6 Hz, 2H), 3.14 — 3.12 (m, 2H), 1.96 — 1.84 (m, 4H), 1.79 (s, 5H), 1.54 (s, 3H) and 1.38 (s, 9H) 9pm (CDC13) 8 6.13 (d, J = 1.6 Hz, 1H), 5.89 (d, J = 1.4 Hz, 1H), 4.87 (d, J = 7.0 Hz, 1H), 4.59 (s, 1H), 3.26 (dd, J = 9.2, 4.3 Hz, 4H), 1.98 — 1.74 (m, 6H), 1.65 (dd, J = 15.9, 7.3 Hz, 3H), 1.47 (s, 9H) (CDC13) 8 8.65 (d, J = 2.0 Hz, 1H), 8.37 (d, J = 2.0 Hz, 1H), 8.27 (d, J = 4.8 Hz, 2H), 6.60 (d, J = 2.4 Hz, 1H), 6.51 (t, J = 4.8 Hz, 1H), 6.36 (d, J = 2.4 Hz, 1H), 6.15 (d, J = 7.8 Hz, 1H), 5.20 (d, J = 7.7 Hz, 1H), 4.04 (d, J = 7.9 Hz, 1H), 3.96 — 3.82 (m, 4H), 3.70 (s, 1H), 3.39 — 3.24 (m, 4H), 1.94 (dd, J 13.7, 4.4 Hz, 6H), 1.78 (dt, J = H NMR (300 MHz, unless Cmpd. ESMS Compound Structure indicated ise) (M+H) NMR peaks given as 8 values (CDC13) 5 8.64 (d, J = 1.9 Hz, 1H), 8.35 (d, J =1.9 Hz, 1H), 6.58 (t, J = 5.1 Hz, 2H), 6.34 (d, J = 2.3 Hz, 1H), 6.10 (d, J = 7.3 Hz, 1H), 4.03 (d, J = 8.3 19 Map6 400.46 Hz, 1H), 3.88 (t, J = 4.7 Hz, E J 6H), 3.68 (s, 1H), 3.42 (s, 3H), 3.37 — 3.23 (m, 4H), 1.98 — 1.78 0 (m, 6H), 1.69 (dd, J = 15.8, 7.5 Hz, 2H) (400.0 MHz, CDC13) 3 8.52 (d, J: 1.7 Hz, 1H), 8.23 (d, J = 1.6 3 Hz, 1H), 6.47 (d, J = 1.9 Hz, 1H), 6.19 (s, 1H), 6.03 (s, 1H), .19 (s, 1H), 4.76 (d, J = 7.6 Hz, 1H), 4.47 (s, 2H), 3.87 — 20 468.23 3.76 (m, 4H), 3.60 (s, 2H), 3.45 (d, J: 11.6 Hz, 2H), 3.13 — 3.10 (m, 2H), 2.61 (s, 1H), 2.13 — 2.04 (m, 1H), 1.95 — 1.85 (m, 5H), 1.79 (s, 5H) and 1.62 — 1.58 (m, 2H) 21 426.31 (400.0 MHz, CDC13) 5 8.54 (s, 1H), 8.22 (s, 1H), 6.43 (s, 1H), Z_ 6.19 (s, 1H), 6.02 (s, 1H), 4.47 (s, 2H), 4.38 (d, J = 5.2 Hz, 1H), 4.28 (s, 1H), 3.74 (s, 1H), 22 425.35 3.60 (s, 1H), 3.42 (s, 4H), 3.14 OQZ — 3.09 (m, 4H), 2.05 — 1.87 (m, 3H), 1.79 (s, 3H), 1.55 (d, J = 7.1 Hz, 2H) and 1.21 — 1.05 (m, 2014/024767 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 3 8.20 (d, J = 4.9 Hz, 2H), 6.46 (t, J = 4.8 Hz, 1H), 6.05 (d, J = 1.6 Hz, 1H), 5.82 (s, 1H), 5.24 (s, 1H), 4.82 (d, J = 7.0 Hz, 1H), 3.98 (s, 1H), 3.85 — 3.72 (m, 4H), 3.60 (s, 1H), 3.23 — 3.06 (m, 4H), 1.95 — 1.62 m, 8H . (400 MHz, CDC13) 8 8.65 (s, 1H), 8.37 (d, J =18 Hz, 1H), 8.08 (d, J = 4.9 Hz, 1H), 7.41 (t, J = 7.7 Hz, 1H), 6.61 (s, 1H), 6.58 — 6.53 (m, 1H), 6.46 — 6.30 (m, 2H), 6.15 (d, J = 7.3 Hz, 1H), 4.56 (s, 1H), 3.98 — 3.78 (m, 5H), 3.76 — 3.61 (m, 1H), 3.42 = — 3.24 (m, 4H), 1.97 (d, J 29.6 Hz, 6H), 1.86 — 1.66 (m, (CDC13) a 8.69 (d, J = 2.0 Hz, 1H), 8.42 (d, J = 2.0 Hz, 1H), 8.26 (s, 1H), 7.14 (d, J = 2.1 Hz, 1H), 6.64 (d, J = 2.4 Hz, 1H), 6.38 (d, J = 2.3 Hz, 1H), 6.24 (d, J = 6.8 Hz, 1H), 4.31 (q, J = 7.1 Hz, 2H), 3.97 — 3.81 (m, 5H), 3.41 — 3.24 (m, 4H), 2.22 (d, J = 7.5 Hz, 2H), 1.90 (dd, J = 22.4, 10.3 Hz, 6H), 1.35 (t, J = 7.1 Hz, 3H) (CDC13) 3 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J =19 Hz, 1H), 6.95 (d, J = 2.5 Hz, 1H), 6.88 (d, J = 2.5 Hz, 1H), 4.82 ? 4.60 (m, 2H), 4.00 ? 3.88 (m, 4H), 3.69 (d, J = 6.8 Hz, 1H), 3.42 ? 3.28 (m, 4H), 2.15 (p, J = 6.7, .6 Hz, 2H), 1.94 ? 1.75 (m, H NMR (300 MHz, unless nd Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 5 8.65 (d, J = 2.0 Hz, 1H), 8.36 (d, J = 2.0 Hz, 1H), 7.98 (dd, J = 2.8, 1.5 Hz, 1H), 7.88 (d, J =15 Hz, 1H), 7.79 (d, J = 2.8 Hz, 1H), 6.62 (d, J = 2.4 Hz, 1H), 6.37 (d, J = 2.4 Hz, 1H), 6.17 (s, 1H), 8.69 — 8.61 (m, 1H), 4.60 (d, J = 7.7 Hz, 1H), 4.08 — 3.83 (m, 5H), 8.71 — 8.57 (m, 1H), 3.73 (t, J = 6.9 Hz, 1H), 3.40 — 3.25 (m, 4H), 1.96 (h, J = 4.9 Hz, 6H), 1.77 (q, J = 7.4, 6.1 Hz, 2H) (400 MHz, CDC13) 5 8.77 — 8.59 (m, 2H), 8.29 (d, J = 4.9 Hz, 2H), 7.01 — 6.87 (m, 2H), 6.61 — 6.48 (m, 1H), 4.82 (s, 1H), 4.05 (s, 1H), 3.93 (t, J = 4.8 Hz, 4H), 3.35 (t, J = 4.8 Hz, 4H), 2.23 (d, J = 13.1 Hz, 2H), 2.05 — 1.82 (m, 6H) (DMSO—ds) 5 12.65 (s, 1H), 8.69 (d, J = 2.0 Hz, 2H), 8.43 (d, J = 2.0 Hz, 1H), 8.00 (d, J = 7.9 Hz, 1H), 6.54 (d, J = 2.5 Hz, 1H), 6.48 (d, J = 2.3 Hz, 1H), 6.17 (d, J = 8.2 Hz, 1H), 4.06 (s, 1H), 3.77 (dd, J = 5.9, 3.8 Hz, 4H), 3.29 (s, 5H), 2.04 — 1.46 (m, 8H) (CDC13) 5 8.66 (d, J = 2.0 Hz, 1H), 8.58 (s, 1H), 8.37 (d, J = 2.0 Hz, 1H), 8.13 (s, 2H), 6.63 (d, J = 2.4 Hz, 1H), 6.37 (d, J = 2.4 Hz, 1H), 6.14 (d, J = 7.6 Hz, 1H), 3.96 — 3.86 (m, 4H), 3.76 (d, J = 7.7 Hz, 2H), 3.54 (d, J = 8.3 Hz, 1H), 3.39 — 3.29 (m, 4H), 2.02 — 1.86 (m, 6H), H NMR (300 MHz, unless Cmpd. ESMS Compound Structure indicated ise) (M+H) NMR peaks given as 8 values (CDC13) a 12.88 — 12.45 (m, 1H), 8.66 (d, J = 2.0 Hz, 1H), 8.37 (d, J = 2.0 Hz, 1H), 7.81 (s, 1H), 6.62 (d, J = 2.3 Hz, 1H), 6.36 (d, J = 2.4 Hz, 1H), 31 422.49 6.12 (d, J = 7.7 Hz, 1H), 5.27 (s, 1H), 5.05 (d, J = 7.6 Hz, 1H), 4.02 — 3.83 (m, 4H), 3.63 (d, J = 47.6 Hz, 2H), 3.44 — 3.22 (m, 4H), 1.91 (q, J = 4.8, 4.3 Hz, 6H), 1.82—1.69 (m, 2H) (CDC13) 3 8.78 (d, J = 1.3 Hz, 1H), 8.66 (d, J = 2.0 Hz, 1H), 8.37 (d, J = 2.0 Hz, 1H), 7.91 (d, J = 1.3 Hz, 1H), 6.62 (d, J = 2.4 Hz, 1H), 6.37 (d, J = 2.4 32 464.6 Hz, 1H), 6.16 (d, J = 7.6 Hz, 1H), 5.13 (d, J: 7.6 Hz, 1H), 4.10 (s, 1H), 3.99 — 3.86 (m, 7H), 3.76 (s, 1H), 3.39 — 3.28 (m, 4H), 1.98 (h, J = 4.8 Hz, 6H), 1.80 (t, J = 8.7 Hz, 2H) (CDC13) 5 8.63 (d, J = 1.9 Hz, 1H), 7.99 (dd, J = 2.8, 1.5 Hz, 1H), 7.94 — 7.85 (m, 1H), 7.79 (d, J = 2.8 Hz, 1H), 7.14 (d, J = 1.0 Hz, 1H), 7.03 — 6.87 (m, 33 407.3 2H), 4.82 (d, J = 5.7 Hz, 1H), 4.70 (d, J = 8.0 Hz, 1H), 4.03 — 3.86 (m, 4H), 3.51 (s, 1H), 3.43 — 3.30 (m, 4H), 2.35 — 1.81 (m, (CDC13) 5 8.69 (dd, J = 3.4, 1.9 Hz, 1H), 8.62 (dd, J = 3.6, 1.9 Hz, 1H), 8.51 (dd, J = 4.8, 2.2 Hz, 2H), 7.01 — 6.83 (m, 3H), .18 (tt, J = 7.0, 3.4 Hz, 1H), 34 408.5 4.79 (tt, J = 6.9, 3.1 Hz, 1H), 4.00 — 3.85 (m, 4H), 3.34 (dq, J = 4.8, 2.6 Hz, 4H), 2.44 — 2.16 (m, 4H), 1.92 (tdd, J = 16.4, 7.7, 2.8 Hz, 4H) 2014/024767 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 8 8.68 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 6.99 — 6.85 (m, 2H), 4.70 (dq, J = 7.3, 3.5 Hz, 1H), 4.05 — 3.84 (m, 8H), 3.40 - 3.25 (m, 4H), 2.19 — 1.93 (m, 6H), 1.77 — 1.64 (m, 2H) (CDC13) 3 8.94 — 8.76 (m, 2H), 8.29 (d, J = 4.8 Hz, 2H), 7.67 (d, J = 1.7 Hz, 1H), 6.53 (t, J = 4.8 Hz, 1H), 6.37 (tt, J = 3.1, 1.5 Hz, 1H), 5.30 (d, J = 7.9 404.2 Hz, 1H), 4.87 (dt, J = 7.5, 3.6 Hz, 1H), 4.43 (q, J = 2.8 Hz, 2H), 4.02 (t, J = 5.5 Hz, 3H), 2.68 (dqd, J = 6.0, 3.4, 3.0, 1.8 Hz, 2H), 2.35 — 2.11 (m, 2H), 2.07 — 1.84 (m, 6H) (CDC13) a 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J =19 Hz, 1H), 8.18 (dd, J = 3.7, 0.8 Hz, 2H), 7.01 — 6.85 (m, 2H), 5.37 — 5.20 37 425.25 (m, 1H), 4.79 (d, J = 5.5 Hz, 1H), 4.02 — 3.85 (m, 4H), 3.43 — 3.29 (m, 4H), 2.31 — 2.15 (m, 2H), 2.02 — 1.85 (m, 6H) (CDC13) a 8.61 (d, J = 2.0 Hz, 1H), 8.55 (d, J =19 Hz, 1H), 8.20 (d, J = 4.8 Hz, 2H), 6.87 (d, J = 2.5 Hz, 1H), 6.81 (d, J = 2.5 Hz, 1H), 6.46 (t, J = 4.8 Hz, 38 1H), 4.95 (s, 1H), 4.45 (n, J = .7, 3.6 Hz, 1H), 3.95 — 3.77 (m, 5H), 3.32 — 3.19 (m, 4H), 2.34 — 2.10 (m, 4H), 1.82 (dt, J = 12.9, 10.0 Hz, 2H), 1.45 1.20 (m, 2H) H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 8 8.72 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.37 (s, 1H), 6.98 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 6.36 (d, J = 1.0 Hz, 1H), 4.91 - 4.76 (m, 1H), 4.00 — 3.88 (m, 4H), 3.45 - 3.24 (m, 4H), 2.34 - 2.17 (m, 2H), 2.03 — 1.84 m, 6H (CDC13) 8 8.71 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 7.15 (d, J = 9.3 Hz, 1H), 7.00 — 6.87 (m, 2H), 6.64 (d, J = 9.3 Hz, 1H), 4.89 - 4.76 (m, 2H), 4.11 - 4.03 (m, 1H), 4.00 — 3.83 (m, 4H), 3.40 - 3.24 (m, 4H), 2.23 (dq, J = 12.9, 6.3, 5.6 Hz, 2H 2.02 - 1.79 , m, 6H ) 8 8.63 (d, J = 1.9 Hz, 1H), 8.55 (d, J =1.9 Hz, 1H), 7.58 (d, J = 23.6 Hz, 2H), 6.89 (d, J = 2.4 Hz, 1H), 6.84 (d, J = 2.5 Hz, 1H), 4.73 (s, 2H), 3.93 — 3.72 (m, 5H), 3.34 — 3.18 (m, 4H), 2.29 (s, 3H), 2.15 (m, 2H), 1.84 (m, 6H) (CDC13) 8 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =1.9 Hz, 1H), 8.52 (d, J = 4.8 Hz, 2H), 7.01 - 6.87 (m, 3H), 5.17 (ddt, J = 8.7, 6.7, 3.4 Hz, 1H), 4.76 — 4.58 (m, 1H), 4.00 — 3.87 (m, 4H), 3.40 — 3.27 (m, 4H), 2.43 - 2.22 (m, 4H), 2.05 - 1.87 (m, 2H), 1.86 — 1.71 m, 2H 2014/024767 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (CDC13) a 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J =19 Hz, 1H), 7.36 (s, 1H), 7.12 (d, J = 3.6 Hz, 1H), 6.95 (d, J = 2.5 Hz, 1H), 6.90 (d, J = 2.5 Hz, 1H), 6.48 (d, J = 3.6 Hz, 1H), 5.18 (d, J = 8.0 Hz, 1H), 4.79 (td, J = 5.4, 2.7 Hz, 1H), 3.97 — 3.85 (m, 4H), 3.70 (q, J = 6.8 Hz, 1H), 3.39 — 3.25 (m, 4H), 2.29 _ 2.12 (m, 2H), 2.07 — 1.77 (m, (CDC13) a 8.71 (d, J = 2.0 Hz, 1H), 8.64 (d, J = 2.0 Hz, 1H), 8.54 (d, J = 2.9 Hz, 1H), 8.47 (d, J = 3.0 Hz, 1H), 6.99 (d, J = 2.4 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 5.81 (d, J = 8.3 Hz, 1H), 4.84 (dt, J = 5.3, 2.8 Hz, 1H), 4.13 — 4.05 (m, 1H), 4.00 — 3.84 (m, 4H), 3.43 — 3.30 (m, 4H), 2.32 — 2.17 (m, 2H), 2.02 — (CDC13) a 8.70 (d, J = 2.0 Hz, 1H), 8.64 (d, J =19 Hz, 1H), 8.29 (s, 2H), 6.98 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 5.29 (d, J = 8.3 Hz, 1H), 4.81 (s, 1H), 4.04 — 3.84 (m, 4H), 3.42 _ 3.31 (m, 4H), 2.22 (s, 2H), 1.92 (d, J = 4.9 Hz, 6H) (CDC13) 3 8.63 (d, J = 2.0 Hz, 1H), 8.52 (d, J = 4.8 Hz, 2H), 8.37 (d, J = 2.0 Hz, 1H), 6.92 (t, J = 4.8 Hz, 1H), 6.62 (d, J = 2.4 Hz, 1H), 6.38 (d, J = 2.4 Hz, 1H), 6.16 (s, 1H), 5.27 (s, 1H), 4.06 — 3.78 (m, 4H), 3.64 (s, 1H), 3.48 — 3.20 (m, 4H), 2.14 (s, 2H), 2.04 — 1.80 (m, H NMR (300 MHz, unless Compound Structure ted otherwise) NMR peaks given as 5 values (CDC13) 3 8.66 (dd, J = 20.5, 1.9 Hz, 2H), 6.93 (dd, J = 17.3, 2.5 Hz, 2H), 4.87 — 4.65 (m, 1H), 4.04 — 3.83 (m, 4H), 3.72 (s, 3H), 3.46 — 3.22 (m, 4H), 2.72 — 2.40 (m, 1H), 2.35 — 1.99 (m, 4H), 1.99 — 1.51 (m, 4H) (DMSO—d6) 5 12.13 (s, 1H), 8.72 (d, J = 1.7 Hz, 1H), 8.58 (d, J: 1.8 Hz,1H), 7.13 (d, J: 2.1 Hz, 1H), 6.83 (d, J = 2.0 Hz, 1H), 4.94 — 4.84 (m, 1H), 3.91 — 3.68 (m, 4H), 3.51 — 3.19 (m, 4H), 2.47 — 2.33 (m, 1H), 2.04 — 1.82 (m, 4H), 1.82 — 1.60 m, 4H (400 MHz, CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.60 (d, J :19 Hz, 1H), 7.99 (s, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.3 Hz, 1H), 6.20 (s, 1H), 5.19 (bs, 1H), 4.81 (bs, 1H), 3.96 — 3.84 (m, 4H), 3.40 — 3.27 (m, 4H), 2.29 — 2.14 (m, 2H),1.99 — 1.81 m, 6H (400 MHz, CDC13) 5 8.69 (d, J :19 Hz, 1H), 8.60 (d, J :19 Hz, 1H), 8.30 (d, J = 2.1Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 5.84 (s, 1H), 5.42 (s, 1H), 4.81 (s, 1H), 3.99 — 3.82 (m, 4H), 3.39 — 3.24 (m, 4H), 2.31 — 2.19 (m, 2H), 2.08 — 2014/024767 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 3 8.69 (d, J =19 Hz, 1H), 8.60 (d, J = 1.9 Hz, 1H), 8.30 (d, J = 2.1 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 5.84 (s, 1H), 5.42 (s, 1H), 4.81 (s, 1H), 3.99 — 3.82 (m, 4H), 3.39 — 3.24 (m, 4H), 2.31 — 2.19 (m, 2H 2.08 — 1.72 , m, 8H (400 MHz, CDC13) 5 8.68 (d, J =14 Hz, 1H), 8.60 (d, J = 1.5 Hz, 1H), 6.93 (s, 1H), 6.90 (s, 1H), 6.28 (s, 1H), 5.06 (d, J = 7.9 Hz, 1H), 4.77 (s, 1H), 4.06 (bs, 1H), 3.97 — 3.84 (m, 4H), 3.38 — 3.25 (m, 4H), 2.27 (s, 6H), 2.18 — 2.09 (m, 2H), 1.94 — 1.83 m, 7H (CDC13) 3.9 Hz, 1H), 8.28 (d, J = 4.8 Hz, 2H), 6.85 (t, J = 1.9 Hz, 2H), 6.51 (t, J = 4.8 Hz, 1H), 5.29 (d, J = 6.3 Hz, 1H), 4.80 (dq, J = 5.5, 2.8 Hz, 1H), 4.57 (d, J = 3.9 Hz, 2H), 4.02 (t, J = 6.2 Hz, 1H), 3.54 — 3.43 (m, 2H), 3.19 (dd, J = 11.6, 2.6 Hz, 2H), 2.27 — 2.14 (m, 2H), 2.08 — 1.85 m, 10H (CDC13) 3 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J =19 Hz, 1H), 7.45 (d, J = 7.8 Hz, 2H), 7.02 — 6.81 (m, 2H), 4.78 (ddd, J = 7.3, 5.6, 3.1 Hz, 1H), 4.66 (d, J = 7.9 Hz, 1H), 4.01 — 3.78 (m, 7H), 3.41 — 3.25 (m, 4H), 2.30 — 2.08 (m, 2H), 1.94 (h, J = 8.8, H NMR (300 MHz, unless Compound Structure ted otherwise) NMR peaks given as 8 values (CDC13) 0 8.73 (d, J = 2.0 Hz, 1H), 8.63 (d, J = 2.0 Hz, 1H), 7.42 (d, J = 9.3 Hz, 1H), 6.96 (dd, J = 19.6, 2.5 Hz, 2H), 6.65 (d, J = 9.3 Hz, 1H), 5.40 (s, 1H), 4.86 (s, 1H), 3.94 (dd, J = .9, 3.8 Hz, 4H), 3.37 (dd, J = 6.0, 3.7 Hz, 4H), 2.27 (d, J = 12.7 Hz, 2H), 2.05 — 1.80 (m,6H) (CDC13) a 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J =19 Hz,1H), 8.28 (d, J = 4.8 Hz, 2H), 6.98 — 6.86 (m, 2H), 6.53 (t, J = 4.8 Hz, 1H), 5.39 (s, 1H), 4.89 — 4.75 (m, 1H), 4.18 — 3.93 (m, 2H), 3.93 — 3.72 (m, 2H), 3.70 — 3.52 (m, 2H), 3.00 (td, J = 12.0, 3.5 Hz, 1H), 2.66 (dd, J = 12.1, .3 Hz, 1H), 2.21 (d, J = 8.9 Hz, 2H), 1.93 (d, J = 6.7 Hz, 6H), 1.30 (d, J = 6.2 Hz, 3H) (CDC13) 5 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J =19 Hz, 1H), 8.28 (d, J = 4.8 Hz, 2H), 7.02 — 6.86 (m, 2H), 6.53 (t, J = 4.8 Hz, 1H), 5.40 (s, 1H), 4.82 (d, J = 5.8 Hz, 1H), 4.20 — 3.95 (m, 2H), 3.94 — 3.53 (m, 6H), 3.03 (td, J = 12.0, 3.5 Hz, 1H), 2.86 (dd,J=12.1, 10.4 Hz, 1H), 2.20 (d, J = 9.2 Hz, 2H), 2.11 — 1.80 (m, 7H) (400 MHz, methanol—d4) 5 8.69 (d, J = 2.0 Hz, 1H), 8.56 (d, J = 2.0 Hz, 1H), 7.12 (d, J = 2.3 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 5.36 (s, 1H), 3.97 (s, 1H), 3.91 — 3.86 (m, 4H), 3.84 (s, 6H), 3.43 — 3.35 (m, 4H), 2.23 — 2.10 (m, 2H), 2.00 — 1.81 (m, WO 59690 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J: 1.9 Hz, 1H), 8.36 (d, J =18 Hz, 1H), 7.54 (dd, J = 8.8, 2.2 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 6.37 (d, J = 8.7 Hz, 1H), 5.11 (s, 1H), 4.80 (s, 1H), 3.94 (s, 1H), 3.94 — 3.79 (m, 4H), 3.38 — 3.25 (m, 4H), 2.32 — 2.12 (m, 2H), 2.02 — 1.78 (m, 6H) (CDC13) 5 8.71 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 7.06 — 6.88 (m, 3H), 6.80 (dd, J = 9.4, 6.3 Hz, 1H), 4.97 — 4.71 (m, 2H), 4.14 (q, J = 7.1 Hz, 1H), 4.01 - 3.85 (m, 4H), 3.44 - 3.24 (m, 4H), 2.23 (d, J = 10.7 Hz, 2H), 1.96 (dt, J = 11.0, 7.6 Hz, 6H) (400 MHz, CDC13) 8 8.69 (d, J =18 Hz, 1H), 8.61 (d, J: 1.9 Hz, 1H), 6.94 (d, J = 2.3 Hz, 1H), 6.87 (s, 1H), 5.78 — 5.64 (m, 1H), 4.73 (s, 1H), 4.01 (s, 1H), 3.97 — 3.78 (m, 4H), 3.43 — 3.18 (m, 4H), 2.26 _ 2.05 (m, 2H), 1.98 — 1.73 (m, 6H), 1.36 — 1.26 (m, 1H), 1.01 _ 0.92 (m, 2H), 0.78 — 0.67 (m, 2H) (400 MHz, CDC13) a 8.69 (d, J :19 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 6.95 (d, J = 2.3 Hz, 1H), 6.87 (d, J = 2.2 Hz, 1H), 6.79 (d, J = 8.1 Hz, 1H), 4.73 (s, 1H), 4.34 (dd, J = 8.3, 5.9 Hz, 1H), 4.04 — 3.84 (m, 7H), 3.40 — 3.28 (m, 4H), 2.35 — 2.24 (m, 1H), 2.23 — 2.11 (m, 2H), 2.09 — 1.98 (m, 1H), 1.97 — 1.76 H NMR (300 MHz, unless nd Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 5 8.53 (s, 1H), 8.29 (d, J = 4.8 Hz, 2H), 6.92 (d, J = 2.5 Hz, 1H), 6.85 (d, J = 2.5 Hz, 1H), 6.52 (t, J = 4.8 Hz, 1H), .25 (d, J = 8.3 Hz, 1H), 4.79 (s, 1H), 4.07 (d, J = 20.4 Hz, 1H), 3.98 — 3.85 (m, 4H), 3.43 — 3.21 (m, 4H), 3.05 — 2.83 (m, 2H), 2.30 — 2.14 (m, 1H), 2.03 — 1.71 (m, 7H), 1.45 (dq, J = 14.5, 7.3 Hz, 2H), 0.98 (t, J = 7.3 Hz, 3H) (CDC13) 5 8.55 (s, 1H), 8.29 (d, J = 1.5 Hz, 2H), 7.05 — 6.93 (m, 1H), 6.85 (d, J = 2.5 Hz, 1H), .49 (d, J = 8.0 Hz, 1H), 4.80 (d, J = 5.8 Hz, 1H), 4.03 — 3.81 (m, 5H), 3.45 — 3.27 (m, 4H), 2.98 (dd, J = 8.5, 7.0 Hz, 2H), 2.32 — 2.09 (m, 2H), 2.00 — 1.71 (m, 8H), 1.56 — 1.34 (m, 2H), 0.98 (td, J = 7.3, 3.3 Hz, 3H) (CDC13) a 8.76 — 8.66 (m, 3H), 8.61 (d, J = 1.9 Hz, 1H), 6.99 — 6.87 (m, 2H), 5.71 (d, J = 8.1 Hz, 1H), 4.81 (s, 1H), 4.11 (s, 1H), 3.92 (t, J = 4.9 Hz, 4H), 3.34 (t, J = 4.9 Hz, 4H), 2.22 (d, J = 10.2 Hz, 2H), 2.02 — 1.85 (m, 6H) (CDC13) 5 8.77 (d, J = 2.3 Hz, 1H), 8.72 (d, J = 2.3 Hz, 1H), 7.12 (d, J = 2.4 Hz, 1H), 7.02 (d, J = 2.4 Hz, 1H), 4.92 (s, 1H), 4.18 — 4.08 (m, 2H), 3.93 (t, J = 4.9 Hz, 4H), 3.85 — 3.76 (m, 2H), 3.60 (q, J = 7.0 Hz, 2H), 3.47 (t, J = 4.9 Hz, 4H), 2.26 (d, J = 13.3 Hz, 2H), 2.07 (t, J = 10.5 Hz, 2H), 2.01 — 1.72 (m, 2H), 1.26 (t, J = 7.0 Hz, H NMR (300 MHz, unless nd Structure indicated otherwise) NMR peaks given as 8 values (CDC13) a 8.71 (d, J = 2.0 Hz, 1H), 8.64 (d, J =19 Hz, 1H), 8.02 (s, 1H), 6.94 (dd, J = 12.2, 2.5 Hz, 2H), 5.32 (s, 2H), 4.87 (d, J = 8.1 Hz, 1H), 4.79 (s, 1H), 4.01 _ 3.86 (m, 4H), 3.36 (q, J = 5.4, 4.7 Hz, 4H), 2.83 (s, 6H), 2.19 (s, 2H), 1.92 (d, J = 4.8 Hz, 6H) (CDC13) 3 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 8.34 (s, 2H), 7.02 — 6.86 (m, 2H), 6.00 (tt, J = 3.0, 1.5 Hz, 1H), 5.41 — 5.21 (m, 1H), 4.81 (dt, J = 7.2, 3.6 Hz, 1H), 4.31 (q, J = 2.8 Hz, 2H), 4.03 (dd, J = 7.8, 4.4 Hz, 1H), 4.00 — 3.82 (m, 6H), 3.42 — 3.25 (m, 4H), 2.44 (tdd, J = 5.7, 2.9, 1.7 Hz, 2H), 2.22 (dq, J = 11.2, 6.6, 6.0 Hz, 2H), 2.02 — 1.83 (m, 6H) (CDC13) 5 9.05 (s, 1H), 8.88 — 8.71 (m, 3H), 8.49 (s, 1H), 7.06 (d, J = 2.3 Hz, 1H), 6.96 (d, J = 2.3 Hz, 1H), 4.85 (s, 1H), 4.17 (s, 1H), 3.93 (t, J = 4.8 Hz, 4H), 3.42 (t, J = 4.9 Hz, 4H), 2.25 - 2.10 (m, 2H),1.95(d, J = 11.9 Hz, 4H) NW/ (methanol—d4) 5 8.69 (s, 1H), ,00 N 8.56 (s, 1H), 7.20 (s, 1H), 7.10 (d, J = 2.2 Hz, 1H), 6.88 (d, J = N 2.4 Hz, 1H), 4.93 (d, J = 14.3 70 NJ\N N E 1 409.45 Hz, 2H), 3.95 — 3.76 (m, 7H), I 3.42 —3.32 (m, 4H), 3.09 (d,J= O 7.3 Hz, 1H), 2.21 — 2.09 (m, fiN’CHi" 2H,1.856Hi (dd,J=10.8,5.6H,Z H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 5 8.79 — 8.64 (m, 3H), 8.59 (d, J =19 Hz, 1H), 6.99 — 6.88 (m, 2H), 6.19 (q, J = 4.7 Hz, 1H), 5.90 (d, J = 8.2 Hz, 1H), 4.81 (dq, J = 5.3, 2.7 Hz, 1H), 4.08 (qd, J = 8.2, 6.5, 2.3 Hz, 1H), 3.97 — 3.87 (m, 4H), 3.39 = — 3.29 (m, 4H), 2.93 (d, J 4.8 Hz, 3H), 2.27 — 2.14 (m, 2H), 2.06 — 1.79 (m, 6H) ) 5 3.97 — 3.87 (m, 4H), 3.39 — 3.29 (m, 4H), 3.10 (s, 6H), 2.22 (dt, J = 11.3, 5.1 Hz, 2H), 1.94 (dd, J = 8.3, 3.9 Hz, 6H), 4.12 - 4.01 (m, 1H), 8.70 (d, J :19 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.46 (s, 2H), 7.00 = 8.1 — 6.87 (m, 2H), 5.57 (d, J Hz,1H), 4.81 (dq, J = 5.1, 2.4 Hz, 1H) (400 MHz, CDC13) 8 8.69 (d, J = 1.2 Hz, 1H), 8.57 (d, J = 21.7 Hz, 1H), 6.93 (d, J = 1.7 Hz, 1H), 6.86 (s, 1H), 5.75 (d, J = 7.4 Hz, 1H), 4.74 (s, 1H), 4.03 — 3.87 (m, 8H), 3.81 (dd, J .2, 7.5 Hz, 1H), 3.37 — 3.25 (m, 4H), 2.96 - 2.76 (m, 1H), 2.23 - 2.07 (m, 4H), 1.84 — 1.78 m, 6H (400 MHz, CDC13) 8 8.69 (d, J :19 Hz, 1H), 8.60 (d, J =1.9 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.86 (d, J = 2.4 Hz, 1H), .42 (d, J = 7.9 Hz, 1H), 4.72 (s, 1H), 3.98 (s, 1H), 3.95 — 3.86 (m, 4H), 3.40 — 3.26 (m, 4H), 3.05 — 2.87 (m, 1H), 2.32 - 2.21 (m, 2H), 2.21 - 2.07 (m, 4H), 2.03 - 1.90 (m, 1H), 1.90 — 2014/024767 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (CDC13) a 8.72 — 8.51 (m, 2H), 7.01 (d, J = 2.5 Hz, 1H), 6.93 (d, J = 2.5 Hz, 1H), 4.84 (s, 1H), 4.40 (s, 2H), 3.99 (s, 1H), 3.83 (dd, J = 5.9, 3.8 Hz, 4H), 3.65 (s, 2H), 3.35 (t, J = 4.9 Hz, 4H), 2.87 (s, 2H), 2.27 — 1.91 (m, 4H), 1.90 — 1.59 (m, 2H), 1.41 (s, 9H) (CDC13) 5 8.70 (t, J = 2.2 Hz, 1H), 8.63 (dd, J = 2.7, 1.9 Hz, 1H), 7.97 (s, 1H), 7.00 — 6.86 (m, 2H), 5.05 (d, J = 8.2 Hz, 1H), 4.77 (s, 1H), 4.02 (s, 1H), 3.93 (t, J = 4.7 Hz, 4H), 3.86 (s, 1H), 3.35 (t, J = 4.8 Hz, 4H), 3.17 (t, J = 6.0 Hz, 1H), 2.89 (d, J = 5.5 Hz, 1H), 2.71 (t, J = 6.0 Hz, 1H), 2.21 (dd, J = 9.2, 4.9 Hz, 2H), 1.91 (d, J = 5.5 Hz, 3H), 1.75 (d, J = 5.6 Hz, (400 MHz, CDC13) 8 8.68 (d, J = 1.9 Hz, 1H), 8.63 — 8.54 (m, 1H), 6.93 (d, J = 2.4 Hz, 1H), 6.86 (d, J = 2.3 Hz, 1H), 5.76 — .55 (m, 1H), 4.93 — 4.67 (m, 4H), 3.99 (d, J = 26.0 Hz, 1H), 3.95 — 3.81 (m, 4H), 3.77 — 3.55 (m, 2H), 3.39 _ 3.28 (m, 4H), 2.21 _ 2.09 (m, 2H), 1.90 — 1.75 (400 MHz, CDC13) 8 8.69 (s, 1H), 8.60 (s, 1H), 6.94 (s, 1H), 6.86 (s, 1H), 5.59 (s, 1H), 4.74 (s, 1H), 4.11 — 3.81 (m, 5H), 3.42 — 3.23 (m, 4H), 2.28 — 2.09 (m, 2H), 1.98 (s, 3H), 1.90 — 1.78 (m, 6H) 2014/024767 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 5 8.69 (d, J = 1.9 Hz, 1H), 8.60 (d, J = 1.9 Hz, 1H), 6.93 (d, J = 2.4 Hz, 1H), 6.86 (d, J = 2.3 Hz, 1H), 5.52 (d, J = 7.3 Hz, 1H), 4.73 (s, 1H), 3.99 (s, 1H), 3.96 — 3.87 (m, 4H), 3.38 — 3.30 (m, 4H), 2.24 — 2.08 (m, 4H),1.88 — 1.79 (m, 6H), 1.16 (t, J = 7.6 Hz, 3H) (400 MHz, CDC13) 5 8.69 (d, J =19 Hz, 1H), 8.60 (d, J :19 Hz, 1H), 6.93 (d, J = 2.4 Hz, 1H), 6.86 (d, J = 2.3 Hz, 1H), .53 (d, J = 7.7 Hz, 1H), 4.73 (s, 1H), 4.00 (s, 1H), 3.95 — 3.84 (m, 4H), 3.39 — 3.25 (m, 4H), 2.22 — 2.06 (m, 4H), 1.88 — 1.76 (m, 6H), 1.70 — 1.61 (m, 2H), 0.94 (t, J = 7.4 Hz, 3H) (400 MHz, CDC13) 5 8.69 (d, J :19 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.87 (d, J = 2.2 Hz, 1H), 6.65 (d, J = 8.5 Hz, 1H), 4.72 (s, 1H), 4.06 (s, 1H), 3.96 — 3.85 (m, 6H), 3.43 (s, 3H), 3.38 — 3.28 (m, 4H), 2.24 — 2.09 (m, 2H), 1.95 — 1.76 (m, 6H) (400 MHz, CDC13) 5 8.68 (d, J =18 Hz, 1H), 8.59 (d, J: 1.8 Hz, 1H), 6.93 (d, J = 2.3 Hz, 1H), 6.86 (d, J = 2.0 Hz, 1H), .53 (d, J = 7.8 Hz, 1H), 4.72 (s, 1H), 4.01 (s, 1H), 3.96 — 3.81 (m, 4H), 3.37 — 3.24 (m, 4H), 2.24 — 2.06 (m, 3H), 2.01 (d, J = 7.0 Hz, 2H), 1.87 — 1.76 (m, 6H), 0.94 (d, J = 6.5 Hz, 2014/024767 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 5 8.62 (d, J = 1.9 Hz, 1H), 8.55 (d, J = 1.9 Hz, 1H), 6.87 (d, J = 2.4 Hz, 1H), 6.80 (d, J = 2.3 Hz, 1H), .62 (d, J = 7.7 Hz, 1H), 4.64 (s, 1H), 3.99 — 3.76 (m, 5H), 3.37 — 3.14 (m, 4H), 2.21 — 1.95 (m, 2H), 1.87 — 1.63 (m, 6H), 1.13 s, 9H (400 MHz, CDC13) 3 8.69 (d, J :19 Hz, 1H), 8.61 (d, J: 1.9 Hz, 1H), 8.19 (d, J = 4.8 Hz, 1H), 6.95 (d, J = 2.3 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 6.70 (dd, J = 51,12 Hz, 1H), 6.56 (s, 1H), 4.87 (d, J = 7.6 Hz, 1H), 4.80 (s, 1H), 3.96 — 3.88 (m, 4H), 3.85 (s, 1H), 3.38 — 3.28 (m, 4H), 2.28 — 2.14 (m, 2H), 2.00 — 1.85 (m, 6H) (CDC13) 5 8.67 (d, J = 2.0 Hz, 1H), 8.62 (d, J = 2.0 Hz, 1H), 7.05 — 6.95 (m, 2H), 6.72 (s, 1H), 4.88 (s, 1H), 3.98 — 3.82 (m, 4H), 3.64 (t, J = 5.1 Hz, 2H), 3.41 — 3.31 (m, 4H), 3.24 (s, 3H), 3.09 (t, J = 5.2 Hz, 2H), 2.68 (s, 3H), 2.30 — 1.99 (m, 4H), 1.86 (d, J = 9.0 Hz, 4H) (CDC13) 3 9.68 (s, 1H), 8.76 — 8.58 (m, 2H), 7.00 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 6.41 (dd, J = 17.7, 11.1 Hz, 1H), 5.65 (d, J = 17.7 Hz, 1H), 5.33 (d, J = 11.1 Hz, 1H), 4.85 (q, J = 3.6 Hz, 1H), 4.01 (s, 1H), 3.94 — 3.70 (m, 4H), 3.47 — 3.19 (m, 4H), 2.27 — 1.94 H NMR (300 MHz, unless Cmpd. ESMS Compound Structure ted otherwise) (M+H) NMR peaks given as 8 values (CDC13) a 8.63 (d, J = 1.9 Hz, 1H), 8.57 (d, J =19 Hz, 1H), 8.20 (dd, J = 5.0, 1.9 Hz, 1H), Z_ 7.57 (dd, J = 7.6, 1.9 Hz, 1H), 6.89 (d, J = 2.5 Hz, 1H), 6.85 (d, J = 2.5 Hz, 1H), 6.51 (dd, J 87 MOON 4312 = 7.6, 4.9 Hz, 1H), 5.12 (d, J = Z \ OZ\_/ 7.7 Hz, 1H), 4.83 _ 4.71 (m, 0H), 4.24 _ 4.03 (m, 1H), 3.92 — / 3.77 (m, 4H), 3.35 — 3.19 (m, 4H), 2.28 — 2.10 (m, 2H), 1.88 (td, J = 8.3, 6.8, 3.9 Hz, 6H) (400 MHz, CDC13) a 8.69 (s, Z_ 1H), 8.63 (s, 1H), 8.57 (s, 1H), WOO 8.30 — 8.12 (m, 2H), 7.85 (t, J = 7.1 Hz, 1H), 7.50 — 7.37 (m, 88 0% 434.25 1H), 6.94 (s, 1H), 6.89 (s, 1H), 4.89 — 4.63 (m, 1H), 4.35 — 4.13 | E:j (m, 1H), 4.01 — 3.78 (m, 4H), N\ 3.43 — 3.19 (m, 4H), 2.37 — 2.15 (m, 2H), 2.12 — 1.82 (m, 6H) (400 MHz, CDC13) 3 8.99 (s, 1H), 8.73 (d, J = 3.4 Hz, 1H), 8.70 (d, J = 1.6 Hz, 1H), 8.60 Z_ (d, J: 1.7 Hz, 1H), 8.11 (d, J: OHNO’O/ 7.8 Hz, 1H), 7.40 (dd, J = 7.6, 4.8 Hz, 1H), 6.95 (d, J = 2.1 89 43422 Hz, 1H), 6.90 (s, 1H), 6.30 (d, J / = 7.6 Hz, 1H), 4.81 (s, 1H), \N [No] 4.22 (s, 1H), 3.97 — 3.85 (m, 4H), 3.41 — 3.23 (m, 4H), 2.32 — 2.17 (m, 2H), 2.01 — 1.84 (m, (400 MHz, CDC13) a 8.75 (dd, J = 4.4, 1.7 Hz, 2H), 8.70 (d, J Nfi =19 Hz, 1H), 8.60 (d, J: 1.9 ’0’o N Hz, 1H), 7.62 (dd, J = 4.4, 1.7 Hz, 2H), 6.95 (d, J = 2.4 Hz, 90 HN 434.22 1H), 6.89 (d, J = 2.5 Hz, 1H), N 6.33 (d, J = 8.2 Hz, 1H), 4.81 0 / I E j (s, 1H), 4.27 — 4.16 (m, 1H), o 3.96—3.87 (m, 4H),3.38—3.31 (m, 4H), 2.30 — 2.16 (m, 2H), 2.00 — 1.86 (m, 6H) H NMR (300 MHz, unless Cmpd. ESMS Compound Structure indicated ise) (M+H) NMR peaks given as 8 values (400 MHz, CDC13) 5 8.69 (d, J =19 Hz, 1H), 8.63 — 8.58 (m, 1H), 7.77 (dd, J = 5.2, 3.2 Hz, 2H), 7.54 — 7.40 (m, 3H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 91 433.21 2.4 Hz, 1H), 6.23 (d, J = 8.0 Hz, 1H), 4.78 (s, 1H), 4.31 — 4.13 (m, 1H), 3.95 — 3.87 (m, 4H), 3.38 — 3.27 (m, 4H), 2.31 — 2.17 (m, 2H), 1.97 — 1.85 (m, (400 MHz, CDC13) 5 8.69 (d, J =19 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 7.47 (d, J = 8.9 Hz, 1H), 7.00 (d, J =10 Hz, 1H), 6.95 (d, J = 0.7 Hz, 1H), 6.94 92 437.24 (d, J = 2.5 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 4.81 (s, 1H), 4.07 (d, J = 12.3 Hz, 4H), 3.98 — 3.85 (m, 4H), 3.41 — 3.24 (m, 4H), 2.34 — 2.12 (m, 2H), 2.06 — 1.83 (m, 6H) (methanol—d4) 5 8.69 (d, J = 2.2 Hz, 1H), 8.59 (d, J = 2.2 Hz, 1H), 8.53 (d, J = 4.9 Hz, 1H), 7.19 (d, J = 5.0 Hz, 1H), 7.15 (d, J = 2.3 Hz, 1H), 6.87 (d, J = 93 451.21 2.4 Hz, 1H), 4.95 (d, J = 7.7 Hz,1H), 4.10 (s, 1H), 3.95 — 3.82 (m, 4H), 3.47 — 3.37 (m, 4H), 2.20 (d, J = 10.1 Hz, 2H), 2.04 — 1.81 (m, 6H) (CDC13) 3 8.68 (d, J = 2.0 Hz, 1H), 8.60 (d, J =19 Hz, 1H), 8.29 (s, 2H), 6.98 — 6.87 (m, 2H), 5.36 (d, J = 8.1 Hz, 1H), 4.79 (q, J = 5.2, 4.0 Hz, 1H), 94 437.44 4.52 (s, 2H), 4.01 (dd, J = 8.1, 4.3 Hz, 1H), 3.95 — 3.84 (m, 4H), 3.39 — 3.28 (m, 4H), 2.25 — 2.12 (m, 2H), 1.99 — 1.82 (m, H NMR (300 MHz, unless Cmpd. ESMS Compound Structure ted otherwise) (M+H) NMR peaks given as 8 values (400 MHz, CDC13) 3 8.70 (d, J = 1.7 Hz, 1H), 8.65 — 8.58 (m, 1H), 7.80 (s, 1H), 7.22 (d, J = 9.6 Hz, 1H), 7.15 (d, J = 7.6 Hz, 1H), 6.95 (d, J = 2.4 Hz, 95 424.21 1H), 6.89 (d, J = 2.4 Hz, 1H), 4.80 (s, 1H), 4.24 — 4.09 (m, 1H), 3.98 — 3.85 (m, 4H), 3.40 — 3.29 (m, 4H), 2.29 — 2.15 (m, 2H), 2.02 — 1.86 (m, 6H) (400 MHz, CDC13) a 8.89 (d, J = 4.9 Hz, 2H), 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J =19 Hz, 1H), 8.20 (d, J = 8.3 Hz, 1H), 7.45 (t, J = 4.9 Hz, 1H), 6.94 96 435.19 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 4.75 (s, 1H), 4.39 — 4.21 (m, 1H), 4.00 — 3.84 (m, 4H), 3.41 — 3.21 (m, 4H), 2.29 — 2.13 (m, 2H), 2.12 — 1.87 (m, (400 MHz, CDC13) 8 9.25 (d, J = 1.4 Hz, 1H), 8.97 (d, J = 5.0 Hz, 1H), 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =1.9 Hz, 1H), 8.22 = — 8.04 (m, 2H), 6.95 (d, J 97 435.19 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 4.81 - 4.72 (m, 1H), 4.26 - 4.15 (m, 1H), 3.96 — 3.86 (m, 4H), 3.38 - 3.29 (m, 4H), 2.28 - 2.17 (m, 2H), 2.06 — 1.86 (m, 6H) (400 MHz, CDC13) 8 9.33 (s, 1H), 9.12 (s, 2H), 8.70 (d, J = 1.9 Hz, 1H), 8.57 (d, J =19 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 98 435.19 6.44 (d, J = 7.8 Hz, 1H), 4.83 (s, 1H), 4.23 (qd, J = 9.2, 4.7 Hz, 1H), 3.96 — 3.87 (m, 4H), 3.38 — 3.30 (m, 4H), 2.32 — 2.18 (m, 2H), 2.01 — 1.88 (m, 6H) H NMR (300 MHz, unless Compound Structure indicated ise) NMR peaks given as 8 values (400 MHz, CDC13) 3 9.29 (dd, J = 5.0, 1.7 Hz, 1H), 8.70 (d, J = 1.9 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 8.33 (dd, J = 8.4, 1.7 Hz, 2H), 7.67 (dd, J = 8.4, 5.0 Hz, 1H), 6.95 (d, J = 2.5 Hz, 1H), 6.91 (d, J = 2.5 Hz, 1H), 4.85 (s, 1H), 4.29 — 4.13 (m, 1H), 3.98 — 3.85 (m, 4H), 3.40 — 3.26 (m, 4H), 2.32 — 2.16 (m, 2H), 2.12 — 1.98 (m, 2H), 1.99 — 1.87 (m, 4H) (400 MHz, CDC13) 3 11.83 (s, 1H), 8.71 (d, J =19 Hz, 1H), 8.59 (d, J =19 Hz, 1H), 7.55 (d, J = 2.4 Hz, 1H), 7.05 (d, J = 8.5 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.87 (dd, J = 4.7, 2.3 Hz, 1H), 6.84 (d, J = 2.4 Hz, 1H), 4.74 (s, 1H), 4.18 (s, 1H), 3.96 — 3.88 (m, 4H), 3.38 — 3.29 (m, 4H), 2.17 — 2.09 (m, 2H), 1.94 — 1.81 m, 6H (400 MHz, CDC13) 3 8.70 (d, J =19 Hz, 1H), 8.63 (d, J: 1.9 Hz, 1H), 8.07 (s, 1H), 7.01 (d, J = 8.3 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.88 (d, J = 2.4 Hz, 1H), 4.76 (s, 1H), 4.23 — 4.09 (m, 1H), 3.98 — 3.84 (m, 4H), 3.40 — 3.26 (m, 4H), 2.48 (s, 3H), 2.28 — 2.12 (m, 2H), 1.99 — 1.82 (m, 6H) (CDC13) 3 8.71 (d, J = 1.9 Hz, 1H), 8.59 (d, J = 2.0 Hz, 1H), 6.96 (d, J = 2.5 Hz, 1H), 6.89 (d, J = 2.5 Hz, 1H), 4.73 (d, J = .7 Hz, 1H), 4.18 (d, J = 7.7 102 Hz, 1H), 3.93 (dd, J = 5.9, 3.8 Hz, 4H), 3.69 — 3.55 (m, 1H), 3.46 (d, J = 16.5 Hz, 1H), 3.41 = 16.4 — 3.28 (m, 4H), 3.08 (d, J Hz, 1H), 2.17 (d, J = 11.6 Hz, 2H), 2.00 — 1.75 (m, 6H) H NMR (300 MHz, unless Compound ure indicated otherwise) NMR peaks given as 8 values (CDC13) 8 8.72 (d, J = 2.0 Hz, 1H), 8.64 (d, J = 2.0 Hz, 1H), 6.99 (d, J = 2.5 Hz, 1H), 6.93 (d, J = 2.5 Hz, 1H), 5.74 (s, 1H), 4.80 (s, 1H), 4.02 — 3.87 (m, 4H), 3.36 (t, J = 4.9 Hz, 4H), 2.19 (s, 2H), 2.08 — 1.79 (m, 6H) (CDC13) 3 8.73 (s, 1H), 8.68 (d, J = 2.4 Hz, 1H), 6.99 (d, J = 2.4 Hz, 1H), 6.85 (d, J = 2.4 Hz, 1H), 5.69 (d, J = 2.5 Hz, 1H), 4.76 (s, 1H), 3.84 (dd, J = 5.9, 3.9 Hz, 4H), 3.38 (dd, J = 6.0, 3.9 Hz, 4H), 2.15 (d, J: 11.1 Hz, 2H 1.96 — 1.67 , m, 6H (CDC13) 3 8.70 (d, J = 1.9 Hz, 1H), 8.59 (d, J =19 Hz, 1H), 8.30 (d, J =13 Hz, 1H), 7.89 (d, J = 1.4 Hz, 1H), 6.93 (dd, J = 18.4, 2.5 Hz, 2H), 5.52 (d, J = 7.8 Hz, 1H), 4.83 (tt, J = 4.8, 2.7 Hz, 1H), 4.19 — 4.01 (m, 1H), 3.96 — 3.87 (m, 4H), 3.39 — 3.26 (m, 4H), 2.31 — 2.14 (m, 2H), 2.09 — 1.78 (m, 6H) (400 MHz, CDC13) a 8.71 (d, J =19 Hz, 1H), 8.64 (d, J =19 Hz, 1H), 7.88 (dd, J = 7.4, 2.1 Hz, 1H), 7.02 (dd, J = 11.9, 8.3 Hz, 1H), 6.97 (d, J = 2.4 Hz, 106 1H), 6.92 (d, J = 2.4 Hz, 1H), 6.83 (dd, J = 12.4, 7.6 Hz, 1H), 4.78 (s, 1H), 4.25 (s, 1H), 4.03 — 3.85 (m, 4H), 3.44 _ 3.23 (m, 4H), 2.38 (s, 3H), 2.30 — 2.13 H NMR (300 MHz, unless Compound Structure indicated ise) NMR peaks given as 8 values (400 MHz, CDC13) a 8.73 — 8.66 (m, 1H), 8.65 — 8.59 (m, 1H), 8.05 (dd, J = 6.6, 2.8 Hz, 1H), 7.46 — 7.36 (m, 1H), 7.08 (dd, J = 11.1, 8.8 Hz, 1H), 6.95 107 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 6.84 — 6.66 (m, 1H), 4.76 (bs, 1H), 4.22 (bs, 1H), 3.96 — 3.87 (m, 4H), 3.37 — 3.28 (m, 4H), 2.28 _ 2.10 (m, 2H), 2.01 _ 1.86 (m, 6H) (CDC13) 5 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 2.0 Hz, 1H), 8.49 (d, J = 1.4 Hz, 1H), 7.77 (d, J = 1.4 Hz, 1H), 6.93 (dd, J = 16.1, 2.5 Hz, 2H), 5.03 (d, J 108 = 7.9 Hz, 1H), 4.81 (td, J = 5.3, 2.6 Hz, 1H), 4.09 — 3.98 (m, 1H), 3.98 — 3.87 (m, 4H), 3.39 — 3.26 (m, 4H), 3.19 (s, 3H), 3.12 (s, 3H), 2.22 (dt, J = 11.2, 4.9 Hz, 2H), 2.02 — 1.82 (m, 6H) (CDC13) 8 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =1.9 Hz, 1H), 8.10 (d, J = 0.5 Hz, 2H), 6.97 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 5.13 (d, J = 8.3 Hz, 1H), 4.80 (s, 1H), 4.06 — 109 3.86 (m, 5H), 3.35 (dd, J = 5.9, 3.8 Hz, 4H), 2.27 - 2.14 (m, 2H), 1.92 (d, J = 5.1 Hz, 6H), 1.79 - 1.44 (m, 6H), 1.28 (t, J = 7.1 Hz, 1H), 1.03 — 0.83 (m, 2H 0.68 — 0.51 , m, 2H (400 MHz, CDC13) 8 8.69 (d, J = 1.9 Hz, 1H), 8.64 — 8.54 (m, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.86 (d, J = 2.5 Hz, 1H), 6.06 — .78 (m, 1H), 4.79 — 4.68 (m, 110 HN0° 395.19 1H), 4.11 - 3.96(m,1H), 3.96 — 3.86 (m, 4H), 3.40 — 3.27 (m, 4H), 2.13 (dd, J = 11.0, 5.2 Hz, 2H), 1.94 (s, 3H), 1.90 — 1.78 (m, 6H) 2014/024767 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 8 8.70 (d, J =19 Hz, 1H), 8.66 — 8.53 (m, 00 3H), 7.93 (dd, J = 6.4, 5.0 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 112 HN 452.18 6.90 (d, J = 2.4 Hz, 1H), 6.78 (s, 1H), 4.78 (bs, 1H), 4.23 (bs, 1H), 3.97 — 3.85 (m, 4H), 3.38 — 3.27 (m, 4H), 2.30 — 2.15 (m, 2H), 2.02 — 1.86 (m, 6H) (400 MHz, CDC13) 8 8.70 (s, 1H), 8.60 (s, 1H), 6.94 (s, 1H), 6.87 (s, 1H), 5.99 (d, J = 6.8 Hz, 1H), 4.75 (bs, 1H), 4.03 113 439.24 (bs, 1H), 3.99 — 3.83 (m, 4H), 3.43 — 3.21 (m, 4H), 2.33 (s, 1H), 2.24 _ 2.04 (m, 2H), 1.94 — 1.74 (m, 6H), 1.56 (s, 6H) (400 MHz, CDC13) 8 8.70 (d, J =19 Hz, 1H), 8.63 (d, J: 1.9 Hz, 1H), 8.40 (dt, J = 4.3, 1.3 00 Hz, 1H), 8.01 (d, J = 8.5 Hz, 1H), 7.58 — 7.52 (m, 1H), 7.51 — 114 HN 452.15 7.46 (m, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 4.74 (s, 1H), 4.29 — 4.17 (m, 1H), 3.97 — 3.88 (m, 4H), 3.39 — 3.30 (m, 4H), 2.25 — 2.16 (m, 2H), 2.06 — 1.88 (m, 6H) H NMR (300 MHz, unless Compound Structure ted otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 5 8.69 (d, J =18 Hz, 1H), 8.62 (d, J: 1.8 Hz, 1H), 8.09 (dd, J = 7.9, 6.1 Hz, 1H), 7.47 (d, J = 8.1 Hz, 1H), 7.13 (dd, J = 11.8, 7.9 Hz, 115 1H), 6.95 (d, J = 2.3 Hz, 1H), 6.90 (d, J = 2.3 Hz, 1H), 6.82 (s, 1H), 4.77 (s, 1H), 4.24 (s, 1H), 3.96 — 3.88 (m, 4H), 3.38 — 3.30 (m, 4H), 2.27 — 2.14 (m, 2H), 2.01 — 1.87 (m, 6H) (400 MHz, CDC13) 8 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =1.9 Hz, 1H), 7.83 (d, J = 2.7 Hz, 1H), 7.19 — 6.93 (m, 4H), 6.89 116 (d, J = 2.4 Hz, 1H), 4.75 (s, 1H), 4.21 (s, 1H), 3.95 — 3.89 (m, 4H), 3.38 — 3.30 (m, 4H), 2.26 - 2.13 (m, 2H), 2.03 — 1.86 (m, 6H) (400 MHz, CDC13) 8 8.69 (d, J :19 Hz, 1H), 8.62 (d, J =1.9 Hz, 1H), 7.35 (d, J = 2.2 Hz, 1H), 6.99 (d, J = 8.2 Hz, 1H), 6.93 (d, J = 2.4 Hz, 1H), 6.88 117 (d, J = 2.4 Hz, 1H), 6.78 (d, J = 2.3 Hz, 1H), 4.73 (s, 1H), 4.26 - 4.14 (m, 1H), 3.96 — 3.87 (m, 7H), 3.36 — 3.29 (m, 4H), 2.23 - 2.12 (m, 2H), 2.01 - 1.82 (m, (400 MHz, CDC13) 5 10.00 (s, 1H), 8.63 (d, J =19 Hz, 1H), 8.54 (d, J = 1.9 Hz, 1H), 6.93 (s, 1H), 6.87 (d, J = 2.4 Hz, 1H), 6.81 (d, J = 2.4 Hz, 1H), 6.50 (s, 1H), 4.69 (s, 1H), 4.15 — 4.05 (m, 1H), 3.92 — 3.77 (m, 4H), 3.35 — 3.19 (m, 4H), 2.27 (d, J = 0.5 Hz, 3H), 2.18 — 2.04 H NMR (300 MHz, unless nd Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 8 8.70 (s, 1H), 8.63 (s, 1H), 6.99 — 6.50 (m, 3H), 4.76 (d, J = 20.7 Hz, 119 1H), 4.19 (s, 1H), 4.13 — 3.74 (m, 7H), 3.41 - 3.21 (m, 4H), 2.37 — 2.08 (m, 5H), 2.03 — 1.79 (m, 6H) (400 MHz, CDC13) 8 8.73 (d, J = 1.9 Hz, 1H), 8.58 (d, J =1.9 Hz, 1H), 6.97 (d, J = 2.4 Hz, 1H), 6.93 (s, 1H), 6.88 (d, J = 120 2.3 Hz, 1H), 6.53 (s, 1H), 4.79 (s, 1H), 4.24 - 4.15 (m, 1H), 3.96 — 3.86 (m, 4H), 3.40 — 3.27 (m, 4H), 2.22 - 2.15 (m, 2H), 1.94 - 1.82 m, 6H (400 MHz, CDC13) 8 8.70 (d, J =1.9 Hz, 1H), 8.62 (d, J =1.9 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 6.71 (d, J = 2.1 Hz, 1H), 6.54 (dd, J = 3.9, 1.7 Hz, 1H), 6.09 (dd, J = 3.9, 2.6 Hz, 1H), 5.94 (d, J = 8.1 Hz, 1H), 4.76 (s, 1H), 4.11 (s, 1H), 3.98 — 3.86 (m, 7H), 3.39 — 3.27 (m, 4H), 2.27 - 2.14 (m, 2H), 1.95 — 1.83 m, 6H (400 MHz, CDC13) 8 8.70 (s, 1H), 8.61 (s, 1H), 8.51 (s, 1H), 7.50 (s, 1H), 6.95 (s, 1H), 6.89 (s, 1H), 6.16 (d, 1H), 4.80 (s, 1H), 4.18 (s, 1H), 4.01 — 3.78 (m, 4H), 3.44 - 3.23 (m, 4H), 2.33 — 2.16 (m, 2H), 1.91 (d, J = H NMR (300 MHz, unless Cmpd. ESMS Compound Structure ted otherwise) (M+H) NMR peaks given as 8 values (400 MHz, CDC13) 3 8.69 (d, J =18 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 7.50 (d, J = 1.2 Hz, 1H), 7.36 (d, J = 1.0 Hz, 1H), 7.16 (d, J = 7.9 Hz, 1H), 6.94 123 437.21 (d, J = 2.3 Hz, 1H), 6.88 (d, J = 2.3 Hz, 1H), 4.78 (s, 1H), 4.20 — 4.09 (m, 1H), 3.95 — 3.87 (m, 4H), 3.73 (s, 3H), 3.38 — 3.28 (m, 4H), 2.25 — 2.14 (m, 2H), 2.00 — 1.82 (m, 6H) (CDC13) 3 8.68 (d, J = 1.9 Hz, 1H), 8.58 (d, J :19 Hz, 1H), 7.85 = — 7.72 (m, 2H), 6.95 (d, J 2.5 Hz, 1H), 6.86 (d, J = 2.5 124 473.2 Hz, 1H), 4.89 (d, J = 7.5 Hz, 1H), 4.71 (dq, J = 5.5, 2.7 Hz, 1H), 4.00 — 3.85 (m, 7H), 3.47 — 3.27 (m, 5H), 2.19 — 2.07 (m, 2H), 1.97 — 1.65 (m, 6H) (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.55 (d, J :19 Hz, 1H), 7.46 (d, J = 2.0 Hz, 1H), 6.97 (d, J = 2.5 Hz, 1H), 6.81 (dd, J = 22.5, 2.3 Hz, 2H), 5.65 — 5.56 125 473.25 (m, 1H), 4.73 (p, J = 2.5 Hz, 1H), 4.10 (s, 3H), 3.95 — 3.85 (m, 4H), 3.47 (d, J = 15.3 Hz, 1H), 3.36 — 3.27 (m, 4H), 2.23 — 2.08 (m, 2H), 1.98 — 1.62 (m, (CDC13) 5 8.68 (d, J = 1.9 Hz, 1H), 8.58 (d, J :19 Hz, 1H), 7.41 (d, J = 2.3 Hz, 1H), 6.95 (d, J = 2.5 Hz, 1H), 6.86 (d, J = 2.5 Hz, 1H), 6.69 (d, J = 2.3 126 473.25 Hz, 1H), 4.95 (d, J = 7.3 Hz, 1H), 4.72 (h, J = 2.6 Hz, 1H), 4.02 = — 3.82 (m, 7H), 3.52 (d, J 9.0 Hz, 1H), 3.37 — 3.27 (m, 4H), 2.12 (dt, J = 16.1, 5.7 Hz, 2H), 1.97 — 1.65 (m, 6H) WO 59690 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 8 8.62 (d, J = 1.9 Hz, 1H), 8.54 (d, J :19 Hz, 1H), 8.01 (s, 2H), 6.88 (s, 1H), 6.83 (d, J = 2.5 Hz, 1H), 4.93 (d, J = 8.1 Hz, 1H), 4.72 (d, J = 5.8 Hz, 1H), 4.53 (d, J = 6.0 Hz, 2H), 4.38 (d, J = 6.0 Hz, 2H), 3.89 - 3.75 (m, 4H), 3.35 - 3.13 (m, 4H), 2.10 (s, 3H), 1.95 - 1.72 (m, 6H), 1.36 (s, 3H) (CDC13) a 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =19 Hz, 1H), 8.56 (s, 2H), 7.04 — 6.87 (m, 2H), 6.19 (d, J = 6.8 Hz, 1H), .15 (d, J = 8.2 Hz, 1H), 5.01 (d, J = 6.8 Hz, 1H), 4.81 (s, 1H), 4.11 — 3.85 (m, 6H), 3.43 — 3.22 (m, 4H), 2.21 (d, J = 9.5 Hz, 2H), 1.94 (t, J = 3.9 Hz, 6H), 1.36 (t, J = 7.1 Hz, 3H) (CDC13) 8 8.60 (d, J = 1.9 Hz, 1H), 8.53 (d, J =19 Hz, 1H), 7.81 (s, 2H), 6.91 — 6.75 (m, 2H), 5.08 — 4.89 (m, 2H), 4.89 — 129 4.77 (m, 2H), 4.67 (ddd, J = 8.2, 4.7, 1.9 Hz, 3H), 3.94 — 3.72 (m, 5H), 3.34 — 3.17 (m, 4H), 2.21 _ 2.00 (m, 2H), 1.91 — 1.69 (m, 6H) (400 MHz, methanol—d4) 5 8.69 (d, J = 2.0 Hz, 1H), 8.55 (d, J = 2.0 Hz, 1H), 7.10 (d, J = 2.3 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 4.85 — 4.82 (m, 1H), 4.07 (q, J = 6.9 Hz, 2H), 3.95 — 3.81 (m, 4H), 3.64 — 3.53 (m, 1H), 3.42 — 3.35 (m, 4H), 2.20 — 2.02 (m, 2H), 1.94 — 1.66 (m, 6H), 1.24 (t, J = 7.1 Hz, 3H) H NMR (300 MHz, unless Compound ure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 5 8.73 — 8.65 (m, 1H), 8.60 (d, J = 1.9 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.87 (d, J = 2.3 Hz, 1H), 4.90 — 4.58 (m, 2H), 3.97 — 3.88 (m, 4H), 3.83 (d, J = 6.3 Hz, 2H), 3.72 (s, 1H), 3.39 — 3.27 (m, 4H), 2.20 — 2.06 (m, 2H), 1.95 = — 1.76 (m, 7H), 0.93 (d, J 6.7 Hz, 6H) (400 MHz, CDC13) 5 8.70 (d, J = 1.6 Hz, 1H), 8.62 (d, J = 1.7 Hz, 1H), 7.36 (t, J = 7.6 Hz, 2H), 7.19 (t, J = 7.3 Hz, 1H), 7.13 (d, J = 7.7 Hz, 2H), 6.96 (s, 1H), 6.89 (s, 1H), 5.12 (d, J = 7.2 Hz, 1H), 4.77 (s, 1H), 3.98 — 3.85 (m, 4H), 3.79 (s, 1H), 3.39 — 3.28 (m, 4H), 2.29 — 2.11 (m, 2H), 1.98 — 1.79 (m, (CDC13) 5 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.04 (s, 2H), 6.97 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.7 Hz, 1H), 4.79 (s, 2H), 4.07 — 3.83 (m, 6H), 3.42 — 3.25 (m, 4H), 2.29 = — 2.02 (m, 2H), 1.92 (d, J 4.6 Hz, 6H), 1.36 — 1.12 (m, (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.07 (s, 2H), 6.97 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.6 Hz, 1H), 4.99 (d, J = 8.0 Hz, 1H), 4.81 (d, J = 5.9 Hz, 1H), 3.93 (dd, J = 6.0, 3.7 Hz, 5H), 3.81 (s, 3H), 3.45 — 3.24 (m, 4H), 2.21 (d, J = 8.6 Hz, 2H), 2.05 — 1.78 (m, 6H) H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values ) 3 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.19 (s, 2H), 6.96 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 5.12 (d, J = 8.1 Hz, 1H), 135 4.81 (d, J = 5.6 Hz, 1H), 4.09 — 3.85 (m, 5H), 3.63 — 3.41 (m, 4H), 3.43 — 3.26 (m, 4H), 2.69 (t, J = 6.6 Hz, 2H), 2.33 — 2.13 (m, 2H), 2.03 — 1.83 (m, 6H), 1.21 (t, J = 7.0 Hz, 3H) (methanol—d4) 5 8.77 — 8.65 (m, 3H), 8.56 (d, J = 2.0 Hz, 1H), 7.11 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 4.92 (s, 1H), 4.02 (dd, J = 8.4, 4.3 Hz, 1H), 3.93 — 3.83 (m, 4H), 3.69 (t, J = 5.7 Hz, 2H), 3.47 (t, J = .8 Hz, 2H), 3.42 — 3.33 (m, 5H), 2.26 — 2.15 (m, 2H), 2.08 — 1.78 (m, 6H) (CDC13) 5 8.73 — 8.58 (m, 4H), 7.01 = — 6.87 (m, 2H), 6.12 (d, J 7.9 Hz, 1H), 5.57 (d, J = 8.1 Hz, 1H), 4.80 (s, 1H), 4.39 — 137 4.28 (m, 1H), 4.10 (d, J = 6.9 Hz, 1H), 3.97 — 3.87 (m, 4H), 3.54 — 3.29 (m, 9H), 2.21 (d, J = 9.9 Hz, 2H), 2.08 — 1.84 (m, 6H), 1.28 (d, J = 6.8 Hz, 3H) (CDC13) 5 9.04 (d, J = 3.2 Hz, 1H), 8.97 (d, J = 3.3 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 8.55 (d, J :19 Hz, 1H), 6.90 (d, J = 2.5 Hz, 1H), 6.84 (d, J = 2.5 138 Hz, 1H), 6.03 (d, J = 8.2 Hz, 1H), 4.77 (td, J = 5.1, 2.6 Hz, 1H), 4.15 — 4.07 (m, 1H), 3.92 — 3.79 (m, 4H), 3.35 — 3.15 (m, 4H), 2.25 — 2.11 (m, 2H), 1.95 — 1.69 (m, 6H) 2014/024767 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 5 8.74 (d, J =19 Hz, 2H), 8.70 (d, J =19 Hz, 1H), 8.03 (dd, J = 8.9, 2.0 Hz, 1H), 6.97 (d, J = 2.4 Hz, 1H), 6.92 (d, J = 2.4 Hz, 1H), 139 6.37 (d, J = 8.9 Hz, 1H), 6.05 (s, 1H), 4.81 (s, 1H), 3.99 — 3.88 (m, 4H), 3.84 (s, 1H), 3.39 — 3.27 (m, 4H), 2.31 — 2.17 (m, 2H), 2.08 — 1.98 (m, 2H), 1.98 — 1.82 (m, 4H) (400 MHz, CDC13) 3 8.70 (d, J =19 Hz, 1H), 8.61 (d, J: 1.9 Hz, 1H), 8.53 (d, J = 2.1 Hz, 1H), 7.88 (dd, J = 8.8, 2.4 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 6.39 (d, J = 8.7 Hz, 1H), 5.61 (s, 2H), 4.97 (d, J = 7.9 Hz, 1H), 4.80 (s, 1H), 4.02 — 3.82 (m, 5H), 3.42 — 3.26 (m, 4H), 2.27 — 2.14 (m, 2H), 2.00 — 1.81 (m, (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =19 Hz, 1H), 8.09 (s, 2H), 7.01 — 6.86 (m, 2H), 4.88 — 4.75 (m, 1H), 4.08 — 141 3.80 (m, 9H), 3.43 — 3.27 (m, 4H), 3.09 — 2.96 (m, 4H), 2.31 — 2.15 (m, 2H), 2.05 — 1.81 (m, (CDC13) 8 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =19 Hz, 1H), 8.14 (d, J = 0.8 Hz, 2H), 7.01 _ 6.90 (m, 2H), 4.81 (td, J = 5.6, 2.7 Hz, 1H), 4.08 — 3.84 (m, 5H), 3.43 — 3.26 (m, 4H), 2.25 _ 2.10 (m, 5H), 2.02 — 1.83 (m, H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values ) 5 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.02 (s, 2H), 6.95 (dd, J = 11.8, 2.5 Hz, 2H), 4.81 (s, 2H), 4.08 — 3.85 (m, 5H), 3.41 — 3.30 (m, 4H), 2.20 (d, J = 10.1 Hz, 2H), 1.95 (d, J = 19.7 Hz, 6H), 1H 143 NMR (3 00 MHz, Methanol-d4) ? 8.68 (d, J = 2.0 Hz, 1H), 8.56 (d, J = 2.1 Hz, 1H), 7.93 (s, 2H), 7.11 (d, J = 2.5 Hz, 1H), 6.88 (d, J = 2.4 Hz, 1H), 3.96 — 3.71 (m, 5H), 3.37 (dd, J = 5.8, 3.9 Hz, 4H), 2.27 — 2.04 (m, 2H 1.98 — 1.74 , m, 6H. (400 MHz, CDC13) 5 8.69 (d, J :19 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.47 (d, J = 2.1 Hz, 1H), 7.84 (dd, J = 8.7, 2.4 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 6.37 144 (d, J = 8.7 Hz, 1H), 5.94 (d, J = 3.9 Hz, 1H), 4.92 (d, J = 7.8 Hz, 1H), 4.79 (s, 1H), 3.98 — 3.84 (m, 5H), 3.39 — 3.26 (m, 4H), 2.98 (d, J = 4.8 Hz, 3H), 2.27 — 2.12 (m, 2H), 1.97 — 1.83 (400 MHz, CDC13) a 8.69 (d, J =19 Hz,1H),8.61(d,J=1.9 Hz, 1H), 8.20 (s, 1H), 7.61 (d, J = 8.2 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.4 Hz, 1H), 6.43 (d, J = 7.9 Hz, 1H), 4.81(s,1H),3.98 — 3.81 (m, 5H), 3.40 — 3.27 (m, 4H), 3.09 (s, 6H), 2.27 _ 2.15 (m, 2H), 1.99 — 1.83 (m, 6H) H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values ) 5 8.76 (d, J = 2.0 Hz, 1H), 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 7.99 (dd, J = 8.8, 2.2 Hz, 1H), 6.97 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 6.38 (d, J = 8.9 Hz, 1H), 5.13 (s, 1H), 4.82 (s, 1H), 4.11 — 3.73 (m, 8H), 3.44 — 3.27 (m, 4H), 2.30 — 2.17 (m, 2H), 2.07 — 1.79 (m, 6H) (400 MHz, CDC13) 5 10.77 — .42 (m, 1H), 8.70 (d, J :19 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 7.30 (d, J = 8.2 Hz, 1H), 7.15 (d, J = 5.7 Hz, 2H), 6.95 147 (d, J = 2.5 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 4.83 (s, 1H), 4.19 — 4.05 (m, 1H), 3.99 — 3.84 (m, 4H), 3.40 — 3.27 (m, 4H), 2.31 — 2.15 (m, 2H), 2.06 — 1.93 (m, 2H), 1.93 — 1.79 (m, 4H) (DMSO-d6) 5 8.73 (d, J = 1.5 Hz, 3H), 8.59 (d, J :19 Hz, 1H), 8.12 (d, J = 8.2 Hz, 1H), 7.84 (d, J = 7.4 Hz, 1H), 7.14 (d, J = 2.4 Hz, 1H), 6.84 (d, J = 2.3 Hz, 1H), 4.93 (s, 1H), 4.51 148 (ddd, J = 13.3, 8.2, 5.2 Hz, 1H), 4.01 = — 3.74 (m, 6H), 3.55 (q, J 8.0 Hz, 1H), 3.38 — 3.27 (m, 4H), 2.33 — 2.15 (m, 1H), 2.06 (d,J= 11.1 Hz,2H), 1.96 — 1.67 (m, 8H), 1.02 (d, J = 6.3 H NMR (300 MHz, unless Cmpd. ESMS Compound Structure indicated otherwise) (M+H) NMR peaks given as 8 values (DMSO—d6) 5 8.76 — 8.67 (m, 3H), 8.59 (d, J =19 Hz, 1H), 8.32 (d, J = 6.5 Hz, 1H), 7.84 (d, J = 7.3 Hz, 1H), 7.14 (d, J = 2.5 Hz, 1H), 6.84 (d, J = 2.3 149 520.33 Hz, 1H), 4.93 (s, 1H), 4.49 — 4.37 (m, 1H), 3.96 — 3.63 (m, 9H), 3.55 (dd, J = 8.9, 4.2 Hz, 1H), 3.38 — 3.27 (m, 4H), 2.23 — 2.00 (m, 4H), 1.95 — 1.71 (m, (DMSO—d6) 5 8.76 — 8.67 (m, 3H), 8.59 (d, J =19 Hz, 1H), 8.32 (d, J = 6.5 Hz, 1H), 7.84 (d, J = 7.3 Hz, 1H), 7.14 (d, J = 2.5 Hz, 1H), 6.84 (d, J = 2.3 150 520.33 Hz, 1H), 4.93 (s, 1H), 4.49 — 4.37 (m, 1H), 3.96 — 3.63 (m, 9H), 3.55 (dd, J = 8.9, 4.2 Hz, 1H), 3.38 — 3.27 (m, 4H), 2.23 — 2.00 (m, 4H), 1.95 — 1.71 (m, ) 5 8.70 (d, J = 1.9 Hz, 1H), 8.64 (d, J = 2.0 Hz, 1H), 7.93 (s, 2H), 7.02 — 6.90 (m, 2H), 4.82 (t, J = 6.7 Hz, 3H), 151 4.66 (t, J = 6.4 Hz, 2H), 4.14 (q, J = 7.1 Hz, 1H), 4.08 — 3.89 (m, 5H), 3.42 — 3.25 (m, 4H), 2.80 (s, 3H), 2.22 (s, 2H), 2.05 — 1.79 (m, 6H) (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.64 (d, J =1.9 Hz, 1H), 7.94 (s, 2H), 6.99 — 6.90 (m, 2H), 4.82 (s, 1H), 4.05 — 3.87 152 464.21 (m, 5H), 3.44 (q, J = 6.3 Hz, 1H), 3.39 — 3.26 (m, 4H), 2.23 (d, J = 12.4 Hz, 2H), 2.03 - 1.82 (m, 6H), 1.23 (d, J = 6.3 Hz, 6H) WO 59690 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 8 8.64 — 8.49 (m, 2H), 6.93 (d, J = 3.9 Hz, 1H), 6.83 (d, J = 2.4 Hz, 1H), 5.27 (d, J = 8.1 Hz, 1H), 4.94 (t, J = 1.9 Hz, 153 2H), 4.81 (t, J = 1.9 Hz, 2H), 4.72 (s, 1H), 3.96 (s, 1H), 3.89 — 3.78 (m, 4H), 3.37 — 3.25 (m, 4H),2.11 (s, 2H), 1.82 (d, J = .1 Hz, 6H (CDC13) 8 8.68 (dd, J = 8.7, 2.0 Hz, 1H), 8.56 (d, J = 2.0 Hz, 1H), 6.92 (d, J = 2.3 Hz, 1H), 6.84 (d, J = 2.4 Hz, 1H), 4.92 154 (t, J = 2.7 Hz, 2H), 4.82 (t, J = 2.7 Hz, 2H), 4.75 (s, 1H), 3.94 — 3.81 (m, 4H), 3.35 — 3.15 (m, 4H), 2.14 (d, J = 12.0 Hz, 2H), (CDC13) 8 8.71 (d, J = 1.9 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 7.02 — 6.89 (m, 2H), 4.83 (s, 1H), 4.08 — 3.87 (m, 5H), 3.44 — 155 3.33 (m, 4H), 3.27 (d, J = 26.0 Hz, 4H), 2.23 (d, J = 9.8 Hz, 2H), 2.05 — 1.80 (m, 6H), 1.14 (s, 6H) (CDC13) 3 8.70 (d, J = 2.0 Hz, N6} 1H), 8.63 (d, J =19 Hz, 1H), ’0’0 N 7.72 (s, 2H), 6.96 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.5 Hz, HN 1H), 5.03 (s, 1H), 4.80 (q, J = 156 ;\N N 462.23 4.4 Hz, 1H), 4.03 — 3.89 (m, Vl E 1 4H), 3.83 (t, J = 7.1 Hz, 4H), o 3.44 — 3.29 (m, 4H), 2.41 (dq, J N = 8.6, 7.1 Hz, 2H), 2.20 (q, J = Q 5.9 Hz, 2H), 1.99 — 1.81 (m, H NMR (300 MHz, unless Cqungd nd Structure indicated otherwise) ' NMR peaks given as 8 values (CDC13) 3 8.71 (d, J = 2.0 Hz, 1H), 8.64 (d, J = 1.9 Hz, 1H), 8.41 (s, 2H), 6.97 (d, J = 2.4 Hz, 1H), 6.93 (d, J = 2.5 Hz, 158 1H), 5.32 (d, J = 8.1 Hz, 1H), 4.82 (s, 1H), 4.07 (s, 1H), 4.00 — 3.88 (m, 4H), 3.43 — 3.29 (m, 4H), 2.22 (s, 2H), 2.06 — 1.81 (400 MHz, CDC13) 5 8.69 (d, J =19 Hz, 1H), 8.61 (d, J: 1.9 Hz, 1H), 8.05 (d, J = 2.2 Hz, 1H), 7.46 (dd, J = 8.5, 2.3 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 160 6.90 (d, J = 2.4 Hz, 1H), 6.39 (d, J = 8.6 Hz, 1H), 4.77 (s, 1H), 4.53 (s, 2H), 3.95 — 3.87 (m, 5H), 3.36 — 3.32 (m, 4H), 2.25 = — 2.12 (m, 2H), 1.90 (d, J H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values ) 3 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J =19 Hz, 1H), 8.26 (s, 2H), 6.95 (d, J = 2.5 Hz, 1H), 6.90 (d, J = 2.6 Hz, 1H), 5.23 (d, J = 8.1 Hz, 1H), 4.80 (d, J = 5.8 Hz, 1H), 4.26 (s, 2H), 4.03 (s, 1H), 3.97 — 3.85 (m, 4H), 3.44 — 3.21 (m, 7H), 2.32 — 2.09 (m, 2H), 2.06 — 1.70 (m, 6H) (DMSO-d6) 8 8.81 - 8.64 (m, 3H), 8.58 (d, J =1.9 Hz, 1H), 7.99 (d, J = 7.6 Hz, 1H), 7.76 (d, J = 7.4 Hz, 1H), 7.14 (d, J = 2.5 Hz, 1H), 6.84 (d, J = 2.3 Hz, 1H), 4.92 (s, 1H), 3.98 - 3.84 (m, 1H), 4.05 (dq, J = 13.5, 6.7 Hz, 1H), 3.79 (d, J = 9.6 Hz, 4H), 3.32 (d, J = 8.2 Hz, 4H), 2.06 (d, J = 11.8 Hz, 2H), 1.96 — 1.66 (m, 6H), 1.14 (d, J = 6.6 Hz, 6H) (CDC13) 5 8.69 (d, J = 1.9 Hz, 1H), 8.65 — 8.53 (m, 3H), 6.93 (dd, J = 14.6, 2.5 Hz, 2H), 5.48 (d, J = 8.0 Hz, 1H), 4.81 (d, J = 6.1 Hz, 1H), 4.19 — 4.03 (m, 1H), 3.92 (dd, J = 6.0, 3.7 Hz, 4H), 3.65 — 3.54 (m, 4H), 3.34 (dd, J = 5.9, 3.7 Hz, 4H), 2.27 — 2.15 (m, 2H), 2.08 — 1.81 (m, 10H) (400 MHz, CDC13) 5 8.60 (d, J :19 Hz, 1H), 8.52 (d, J :19 Hz, 1H), 8.01 (d, J = 2.1 Hz, 1H), 7.35 (dd, J = 8.8, 2.5 Hz, 1H), 6.86 (d, J = 2.5 Hz, 1H), 6.80 (d, J = 2.5 Hz, 1H), 6.20 (d, J = 8.4 Hz, 1H), 4.68 (s, 1H), 4.47 (d, J = 8.0 Hz, 1H), 3.92 — 3.80 (m, 4H), 3.74 (s, 1H), 3.34 — 3.14 (m, 4H), 2.18 — 2.02 (m, 2H), 1.94 — 1.67 (m, 2014/024767 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 3 8.69 (d, J =19 Hz, 1H), 8.63 (d, J: 1.9 Hz, 1H), 8.44 — 8.37 (m, 1H), 8.33 (d, J = 8.1 Hz, 1H), 7.58 (dd, J = 7.8, 0.9 Hz, 1H), 7.31 (dd, J = 7.7, 4.6 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 4.75 (s, 1H), 4.25 — 4.10 (m, 1H), 3.97 — 3.85 (m, 4H), 3.41 — 3.26 (m, 4H), 2.75 (s, 3H), 2.29 — 2.13 (m, 2H), 2.06 — 1.85 (m, 6H) (400 MHz, CDC13) 3 8.69 (d, J =19 Hz, 1H), 8.63 (d, J: 1.9 Hz, 1H), 8.41 (d, J = 4.5 Hz, 1H), 8.21 (d, J = 8.0 Hz, 1H), 8.08 — 7.98 (m, 1H), 7.25 — 7.22 (m, 1H), 6.95 (d, J = 2.5 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 4.76 (s, 1H), 4.27 — 4.15 (m, 1H), 3.98 — 3.86 (m, 4H), 3.40 — 3.29 (m, 4H), 2.43 (s, 3H), 2.29 — 2.16 (m, 2H), 2.07 — 1.86 (m, (400 MHz, CDC13) 5 8.70 (d, J =19 Hz, 1H), 8.63 (d, J: 1.9 Hz, 1H), 8.37 (dd, J = 1.4, 0.7 Hz, 1H), 8.16 (d, J = 8.4 Hz, 1H), 8.09 (d, J = 8.0 Hz, 1H), 7.66 = — 7.61 (m, 1H), 6.95 (d, J 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 4.75 (s, 1H), 4.29 — 4.16 (m, 1H), 3.97 — 3.86 (m, 4H), 3.39 — 3.29 (m, 4H), 2.41 (s, 3H), 2.28 — 2.15 (m, 2H), 2.04 — 1.84 m, 6H 2014/024767 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 3 8.69 (d, J =18 Hz, 1H), 8.63 (d, J: 1.9 Hz, 1H), 8.39 (d, J =16 Hz, 1H), 8.17 (d, J = 8.6 Hz, 1H), 8.11 (d, J = 8.0 Hz, 1H), 7.66 (dd, J = 7.9, 2.0 Hz, 1H), 6.95 (d, J = 2.3 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 4.76 (s, 1H), 4.31 — 4.14 (m, 1H), 4.00 — 3.85 (m, 4H), 3.42 — 3.25 (m, 4H), 2.73 (q, J = 7.6 Hz, 2H), 2.30 — 2.14 (m, 2H), 1.99 (ddd, J = 34.6, 19.6, 10.3 Hz, 7H), 1.29 (t, J = 7.6 Hz, 3H (400 MHz, CDC13) 3 8.70 (d, J :19 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 8.24 (d, J = 7.8 Hz, 1H), 8.01 (d, J = 7.5 Hz, 1H), 7.72 (t, J = 7.7 Hz, 1H), 7.27 (d, J = 6.6 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 4.82 — 4.68 (m, 1H), 4.27 — 4.13 (m, 1H), 3.98 — 3.86 (m, 4H), 3.41 — 3.28 (m, 4H), 2.60 (s, 3H), 2.30 — 2.18 (m, 2H ,2.09 — 1.88 m, 6H (400 MHz, CDC13) 3 8.69 (d, J =18 Hz, 1H), 8.61 (d, J: 1.9 Hz, 1H), 7.90 (d, J = 7.2 Hz, 1H), 7.83 — 7.78 (m, 1H), 7.76 — 7.69 (m, 1H), 6.96 (d, J = 2.3 Hz, 1H), 6.94 — 6.86 (m, 2H), 4.77 (s, 1H), 4.17 (s, 1H), 4.00 (s, 3H), 3.95 — 3.86 (m, 4H), 3.40 — 3.29 (m, 4H), 2.30 — 2.17 2014/024767 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 5 8.76 (dd, J = 4.9, 0.8 Hz, 1H), 8.70 (d, J =19 Hz, 1H), 8.62 (d, J =19 Hz, 1H), 8.48 — 8.38 (m, 1H), 8.09 (d, J = 8.0 Hz, 1H), 7.67 171 HN’O’O (dd, J = 4.9, 1.6 Hz, 1H), 6.96 ”fig 1: (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 4.76 (s, 1H), 4.31 — 4.14 (m, 1H), 4.01 — 3.83 (m, 4H), 3.43 — 3.26 (m, 4H), 2.31 — 2.15 (m, 2H), 2.08 — 1.87 (m, (400 MHz, CDC13) 5 8.70 (d, J =19 Hz, 1H), 8.64 (d, J =19 Hz, 1H), 8.11 (dd, J: 7.4, 1.4 Hz, 1H), 7.96 (dd, J = 15.6, 7.7 Hz, 1H), 7.82 (d, J = 7.7 Hz, 1H), 7.09 (dd, J = 8.1,18 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.4 Hz, 1H), 4.80 (s, 1H), 4.26 — 4.09 (m, 1H), 3.99 — 3.86 (m, 4H), 3.41 — 3.25 (m, 4H), 2.31 — 2.17 (m, 2H), 2.05 — 1.86 m, 6H (400 MHz, CDC13) a 8.69 (d, J =19 Hz, 1H), 8.62 (d, J =19 Hz, 1H), 8.30 (d, J = 2.1 Hz, 1H), 7.80 (d, J = 7.9 Hz, 1H), 7.32 (ddd, J = 10.3, 8.1, 2.3 Hz, 174 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 4.74 (s, 1H), 4.27 — 4.15 (m, 1H), 4.00 — 3.86 (m, 4H), 3.41 — 3.27 (m, 4H), 2.27 — 2.13 (m, 2H), 2.08 — 1.86 m, 6H H NMR (300 MHz, unless ngd nd Structure indicated otherwise) ' NMR peaks given as 8 values (400 MHz, CDC13) 8 12.21 (s, 1H), 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =1.9 Hz, 1H), 8.17 (d, J = 7.4 Hz, 1H), 8.07 (dd, J = 4.2, 1.5 Hz, 1H), 7.33 (ddd, J = 10.0, 8.5, 2.9 Hz, 2H), 6.97 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.5 Hz, 1H), 4.83 — 4.74 (m, 1H), 4.24 — 4.11 (m, 1H), 3.99 — 3.86 (m, 4H), 3.41 — 3.26 (m, 4H), 2.30 — 2.18 (m, 2H), 2.08 — 1.87 (m, 6H) (400 MHz, CDC13) 5 11.13 (s, 1H), 8.71 (d, J :19 Hz, 1H), 8.59 (d, J :19 Hz, 1H), 7.64 — 7.39 (m, 2H), 7.07 (d, J = 6.8 177 Hz, 1H), 7.02 — 6.79 (m, 3H), 4.76 (s, 1H), 4.32 — 4.15 (m, 1H), 3.96 — 3.85 (m, 4H), 3.42 — 3.24 (m, 4H), 2.39 — 2.14 (m, 2H ,2.10 — 1.82 m, 6H (400 MHz, CDC13) 5 8.70 (d, J =19 Hz, 1H), 8.64 (d, J :19 ”q Hz, 1H), 8.14 (dd, J = 7.6, 0.7 Hz, 1H), 7.91 (d, J = 8.1 Hz, 0 N 1H), 7.81 (t, J: 7.8 Hz, 1H), 7.46 (dd, J = 7.9, 0.7 Hz, 1H), 178 468.17 6.96 (d, J = 2.4 Hz, 1H), 6.91 \ (d, J = 2.4 Hz, 1H), 4.80 (s, / E 1 1H), 4.24 —4.08 (m, 1H), 3.99 — O 3.83 (m, 4H), 3.41 — 3.26 (m, 4H), 2.33 _ 2.18 (m, 2H), 2.11 _ 1.98 (m, 2H), 1.98 — 1.87 (m, H NMR (300 MHz, unless nd Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 5 8.70 (d, J =19 Hz, 1H), 8.63 (d, J: 1.9 m Hz, 1H), 8.13 (d, J = 7.7 Hz, 00 N 1H), 8.02 (d, J = 7.8 Hz, 1H), 7.86 (t, J = 7.7 Hz, 1H), 7.48 HN (d, J = 7.8 Hz, 1H), 6.96 (d, J = [N] 2.4 Hz, 1H), 6.91 (d, J = 2.4 Hz, 1H), 4.85 (s, 2H), 4.79 (s, 1H), 4.28 — 4.15 (m, 1H), 4.00 — 3.87 (m, 4H), 3.41 — 3.27 (m, 4H), 2.88 (s, 1H), 2.33 — 2.16 (m, 2H), 2.07 — 1.88 (m, 6H) (400 MHz, CDC13) 5 8.68 (d, J :19 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.16 (d, J = 7.8 Hz, ,0 1H), 7.56 (dd, J = 8.4, 7.3 Hz, 1H), 7.43 (d, J = 6.7 Hz, 1H), 180 GAG 6.96 (d, J = 2.4 Hz, 1H), 6.91 (:1 (d, J = 2.4 Hz, 1H), 6.50 (d, J = 7.8 Hz, 1H), 4.74 (s, 1H), 4.21 — 4.07 (m, 1H), 3.97 — 3.86 (m, L7 4H), 3.54 — 3.48 (m, 4H), 3.40 — 3.29 (m, 4H), 2.26 — 2.14 (m, 2H 2.07 — 1.88 , m, 10H (400 MHz, CDC13) 5 8.91 (s, 2H), 8.71 (d, J :19 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 8.30 (dd, J = 7.7, 0.7 Hz, 1H), 8.11 (t, J = 7.9 Hz, 1H), 7.74 (d, J = 8.2 Hz, 1H), 7.57 (dd, J = 8.0, 181 0.7 Hz, 1H), 6.97 (d, J = 2.4 Hz, 1H), 6.92 (d, J = 2.4 Hz, 1H), 4.82 (s, 1H), 4.27 — 4.11 (m, 1H), 3.99 — 3.85 (m, 4H), 3.42 — 3.27 (m, 4H), 2.34 — 2.20 (m, 2H), 2.12 — 2.00 (m, 2H), 2.00 — 1.84 m, 4H H NMR (300 MHz, unless Compound Structure ted otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 8 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J =1.9 Hz, 1H), 8.15 (s, 1H), 7.43 (d, J = 8.1 Hz, 1H), 6.97 (d, J = 2.3 182 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 4.82 (s, 1H), 4.24 — 4.13 (m, 1H), 3.98 — 3.86 (m, 4H), 3.40 — 3.27 (m, 4H), 2.30 — 2.16 m, 2H 2.05 — 1.78 , m, 6H (400 MHz, CDC13) a 8.69 (d, J :19 Hz, 1H), 8.63 (d, J :19 Nfi Hz, 1H), 7.86 (d, J = 3.1 Hz, 0 N 0 1H), 7.57 (d, J = 3.1 Hz, 1H), 7.38 (d, J = 8.0 Hz, 1H), 6.95 183 HN 440.12 (d, J = 2.4 Hz, 1H), 6.90 (d, J = AVS N 2.4 Hz, 1H), 4.79 (s, 1H), 4.25 \ — 4.09 (m, 1H), 3.97 — 3.88 (m, N / E j 0 4H), 3.39 — 3.29 (m, 4H), 2.28 — 2.17 (m, 2H), 2.07 — 1.96 (m, 2H), 1.96 — 1.85 (m, 4H) (400 MHz, CDC13) 5 8.69 (d, J =19 Hz, 1H), 8.62 (d, J :19 Nfi Hz, 1H), 7.50 (d, J = 1.1 Hz, 1H), 7.28 (d, J = 8.3 (0’ \©/O HZ, 1H), 6.95 (d, J = 2.4 HZ, 1H), 6.89 (d, J = 2.4 Hz, 1H), 184 “N 45409 DAW/ 4.78 (s, 1H), 4.23 — 4.07 (m, S N CH3[ ] 1H),3.99 _ 3.87 (m,4H),3.40 _ 3.27 (m, 4H), 2.53 (d, J =10 0 Hz, 3H), 2.28 — 2.14 (m, 2H), 2.04 — 1.95 (m, 2H), 1.95 — 1.84 (m, 4H) (400 MHz, CDC13) a 8.70 (t, J = 5.6 Hz, 1H), 8.61 (dd, J = Nfi 12.5,1.9 Hz, 1H), 7.35 (d, J = 0 N 8.0 Hz, 1H), 7.11 (d, J = 0.9 0 Hz, 1H), 7.01 — 6.92 (m, 1H), HN 6.89 (d, J = 2.4 Hz, 1H), 4.85 — 185 454-13 470 (m, 1H), 4.26 — 4.11 (m, S N \ / E 1 1H), 3.90 (dd, J = 15.3, 10.4 0 Hz, 4H), 3.42 — 3.25 (m, 4H), CH3 2.49 (d, J = 0.9 Hz, 3H), 2.30 — 2.16 (m, 2H), 2.12 — 1.84 (m, H NMR (300 MHz, unless Compound Structure ted otherwise) NMR peaks given as 8 values (CDC13) 8 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J =1.9 Hz, 1H), 8.01 (d, J = 5.8 Hz, 1H), 7.00 - 6.86 (m, 2H), 6.03 (d, J = 5.8 Hz, 1H), 4.80 (d, J = 5.8 Hz, 1H), 4.07 (s, 1H), 3.97 - 3.83 (m, 7H), 3.41 — 3.28 (m, 4H), 2.20 (dd, J = 12.3, 5.6 Hz, 2H), 1.95 (dh, J = 11.8, 5.6, 4.7 Hz, (CDC13) 8 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =1.9 Hz, 1H), 7.70 (s, 1H), 6.96 (q, J = 2.6 Hz, 2H), 5.75 (d, J = 6.5 Hz, 187 1H), 4.82 (s, 1H), 4.65 (s, 1H), 3.93 (dd, J = 5.9, 3.8 Hz, 4H), 3.63 (s, 4H), 3.36 (dd, J = 6.1, 3.7 Hz, 4H), 2.14 (s, 2H), 1.95 (d, J = 31.2 Hz, 6H) (400 MHz, CDC13) 8 9.02 (d, J = 2.6 Hz, 1H), 8.70 (d, J =1.9 Hz, 1H), 8.61 (d, J =1.9 Hz, 1H), 8.17 (dd, J = 9.3, 2.6 Hz, 1H), 6.97 (d, J = 2.4 Hz, 1H), 188 6.91 (d, J = 2.4 Hz, 1H), 6.36 (d, J = 9.3 Hz, 1H), 5.37 (s, 1H), 4.82 (s, 1H), 4.04 (s, 1H), 3.96 - 3.87 (m, 4H), 3.40 - 3.27 (m, 4H), 2.31 — 2.18 (m, 2H), 2.03 - 1.84 (m, 6H) (400 MHz, CDC13) 8 8.69 (d, J = 1.6 Hz, 1H), 8.61 (d, J= 1.7 Hz, 1H), 8.32 (s, 1H), 7.56 (d, J = 6.7 Hz, 1H), 6.96 (d, J = 2.2 Hz, 1H), 6.90 (d, J = 2.3 Hz, 189 474.147 1H), 6.40 (d, J = 8.7 Hz, 1H), 4.96 (s, 1H), 4.80 (s, 1H), 4.01 - 3.84 (m, 5H), 3.42 — 3.24 (m, 4H), 2.21 (d, J = 8.4 Hz, 2H), H NMR (300 MHz, unless Compound Structure ted otherwise) NMR peaks given as 8 values (CDC13) 5 8.52 (s, 1H), 8.29 (d, J = 4.8 Hz, 2H), 6.90 (d, J = 2.5 Hz, 1H), 6.85 (d, J = 2.5 Hz, 1H), 6.52 (t, J = 4.8 Hz, 1H), .36 (s, 1H), 4.79 (dq, J = 5.6, 2.9 Hz, 1H), 4.04 (dp, J = 8.0, 3.8 Hz, 1H), 3.97 — 3.85 (m, 4H), 3.38 — 3.26 (m, 4H), 2.70 (s, 3H), 2.29 — 2.11 (m, 2H), 2.00 — 1.78 (m, 6H) (CDC13) 5 8.52 (s, 1H), 8.29 (d, J = 4.8 Hz, 2H), 6.90 (d, J = 2.5 Hz, 1H), 6.85 (d, J = 2.5 Hz, 1H), 6.53 (t, J = 4.8 Hz, 1H), .42 (d, J = 7.9 Hz, 1H), 4.80 (dq, J = 5.9, 2.9 Hz, 1H), 4.11 — 3.98 (m, 1H), 3.91 (dd, J = 5.9, 3.8 Hz, 4H), 3.42 — 3.21 (m, 4H), 2.71 (s, 3H), 2.31 — 2.07 (m, 2H), 2.04 — 1.77 (m, 6H) (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =19 Hz, 1H), 7.97 (s, 1H), 6.97 (d, J = 2.5 Hz, 1H), 6.93 (d, J = 2.5 Hz, 1H), 5.36 (s, 1H), 4.80 (d, J = 192 6.2 Hz, 1H), 4.65 (d, J = 0.9 Hz, 2H), 4.02 (t, J = 5.8 Hz, 3H), 3.98 — 3.82 (m, 4H), 3.42 — 3.30 (m, 4H), 2.80 (t, J = 5.8 Hz, 2H), 2.29 — 2.11 (m, 2H), 2.03 — 1.77 (m, 7H) (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =19 Hz, 1H), 7.95 (s, 2H), 7.05 — 6.88 (m, 2H), 4.92 (s, 1H), 4.79 (s, 1H), 3.93 (t, J = 4.8 Hz, 5H), 3.60 — 3.44 (m, 4H), 3.37 (d, J = 10.5 Hz, 9H), 2.20 (d, J = 6.9 Hz, 2H), 1.91 (d, J = 4.6 Hz, 6H) H NMR (300 MHz, unless Compound ure indicated otherwise) NMR peaks given as 8 values (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J =19 Hz, 1H), 8.28 (d, J = 0.9 Hz, 1H), 6.97 (d, J = 2.5 Hz, 1H), 6.91 (d, J = 2.5 Hz, 1H), 5.74 — 5.58 (m, 194 1H), 5.16 (d, J = 8.0 Hz, 1H), 4.82 (dq, J = 5.4, 2.7 Hz, 1H), 4.06 = — 3.85 (m, 7H), 3.70 (d, J 14.0 Hz, 1H), 3.42 — 3.28 (m, 4H), 2.30 — 2.16 (m, 2H), 1.99 — 1.75 (m, 6H) (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 2.0 Hz, 1H), 7.43 (dd, J = 8.6, 7.2 Hz, 1H), 7.02 — 6.86 (m, 3H), 6.55 (dd, J 195 = 8.6, 0.8 Hz, 1H), 4.80 (d, J = 6.6 Hz, 2H), 4.10 — 3.81 (m, 5H), 3.47 — 3.25 (m, 4H), 2.30 — 2.11 (m,2H), 1.99 — 1.81 (m, (CDC13) 8 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J =19 Hz, 1H), 7.61 (d, J = 9.4 Hz, 1H), 7.41 (d, J = 7.2 Hz, 1H), 7.05 — 6.87 196 (m, 2H), 6.65 (s, 1H), 4.86 (s, 1H), 4.04 — 3.87 (m, 7H), 3.74 (s, 1H), 3.43 — 3.27 (m, 4H), 2.21 (d, J = 10.8 Hz, 2H), 1.98 d, J: 23.5 Hz, 6H (400 MHz, CDC13) 8 8.68 (d, J =19 Hz, 1H), 8.61 (d, J: 1.9 Hz, 1H), 8.13 — 8.04 (m, 1H), 7.67 (d, J = 2.4 Hz, 1H), 6.99 — 6.93 (m, 2H), 6.90 (d, J = 2.4 Hz, 1H), 6.33 (d, J = 8.7 Hz, 1H), 4.77 (s, 1H), 3.99 — 3.65 (m, 7H), 3.39 — 3.27 (m, 4H), 2.25 — 2.10 (m, 2H), 1.96 — 1.82 H NMR (300 MHz, unless nd Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 5 8.69 (d, J = 1.6 Hz, 1H), 8.61 (d, J: 1.7 Hz, 1H), 8.57 (d, J = 2.1 Hz, 1H), 7.89 (dd, J = 8.9, 2.3 Hz, 1H), 6.95 (s, 1H), 6.90 (s, 1H), 6.62 (d, J = 9.0 Hz, 1H), 5.99 198 (d, J = 7.7 Hz, 1H), 4.78 (s, 1H), 4.18 (s, 1H), 4.03 — 3.81 (m, 4H), 3.76 — 3.60 (m, 4H), 3.42 — 3.25 (m, 4H), 2.62 — 2.44 (m, 4H), 2.36 (s, 3H), 2.29 — 2.14 (m, 2H), 1.99 — 1.84 (m, (400 MHz, CDC13) 5 8.73 — 8.65 (m, 3H), 8.60 (d, J =19 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), .93 (d, J = 8.0 Hz, 1H), 4.79 (s, 1H), 4.23 — 4.09 (m, 1H), 3.97 — 3.88 (m, 8H), 3.40 — 3.25 (m, 4H), 2.53 — 2.42 (m, 4H), 2.34 (s, 3H), 2.26 — 2.18 (m, 2H 1.97 — 1.83 , m, 6H (400 MHz, CDC13) 5 8.69 (d, J =19 Hz, 1H), 8.61 (d, J: 1.9 Hz, 1H), 7.51 — 7.42 (m, 2H), 6.98 = — 6.85 (m, 3H), 6.07 (d, J 8.0 Hz, 1H), 4.77 (s, 1H), 4.25 — 4.11 (m, 1H), 3.99 — 3.85 (m, 4H), 3.40 — 3.27 (m, 4H), 3.26 — 3.14 (m, 4H), 2.67 — 2.52 (m, 4H), 2.36 (s, 3H), 2.28 — 2.13 (m, 2H), 1.98 — 1.84 (m, 6H) (400 MHz, CDC13) 5 9.47 (s, 1H), 8.68 (d, J :17 Hz, 1H), 8.56 (d, J =17 Hz, 1H), 8.21 — 8.11 (m, 1H), 6.97 — 6.85 (m, 201 4H), 4.82 (s, 1H), 4.23 — 4.07 (m, 1H), 3.96 — 3.87 (m, 4H), 3.38 — 3.29 (m, 4H), 3.03 (s, 4H), 2.65 (s, 4H), 2.37 — 2.25 (m, 5H), 2.02 — 1.84 (m, 6H) H NMR (300 MHz, unless Compound ure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 3 8.69 (d, J =18 Hz, 1H), 8.63 (d, J: 1.9 Hz, 1H), 8.27 (dd, J = 4.7, 1.9 Hz, 1H), 8.19 (s, 1H), 8.11 (d, J = 6.8 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.92 (d, J = 2.3 Hz, 1H), 6.51 (dd, J = 7.4, 4.9 Hz, 1H), 4.76 (s, 1H), 4.30 (s, 1H), 4.02 — 3.90 (m, 4H), 3.88 (s, 3H), 3.41 — 3.26 (m, 4H), 2.29 — 2.11 (m, 2H), 2.11 — 1.85 (m, (CDC13) a 8.70 (d, J = 1.9 Hz, 1H), 8.60 (d, J :19 Hz, 1H), 8.15 (s, 1H), 6.93 (dd, J = 17.9, 2.5 Hz, 2H), 6.43 (d, J = 6.1 Hz, 1H), 5.20 (s, 1H), 4.82 (s, 1H), 4.00 — 3.82 (m, 4H), 3.44 — 3.25 (m, 4H), 2.23 (d, J = 11.2 Hz, 2H), 1.91 (s, 6H) (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.09 (d, J = 6.0 Hz, 1H), 6.93 (dd, J = 16.1, 2.5 Hz, 2H), 6.15 (d, J = 6.0 Hz, 1H), 5.10 (d, J = 204 8.0 Hz, 1H), 4.81 (td, J = 5.5, 2.7 Hz, 1H), 3.97 — 3.87 (m, 4H), 3.49 (s, 1H), 3.39 — 3.27 (m, 4H), 2.49 (s, 3H), 2.27 — 2.14 (m, 2H), 2.03 — 1.80 (m, (CDC13) 8 8.70 (d, J = 1.9 Hz, 1H), 8.61 (dd, J = 53,19 Hz, 1H), 8.19 — 8.06 (m, 1H), 6.99 — 6.84 (m, 2H), 5.34 _ 5.21 (m, 1H), 4.76 (d, J = 9.7 Hz, 3H), 3.92 (t, J = 4.9 Hz, 4H), 3.81 (s, 1H), 3.33 (dd, J = 5.7, 4.1 Hz, 4H), 2.87 (d, J = 5.2 Hz, 3H), 2.19 (d, J = 8.5 Hz, 2H), 1.88 2014/024767 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 3 8.68 (d, J =19 Hz, 1H), 8.61 (d, J: 1.9 Hz, 1H), 7.82 (d, J = 2.8 Hz, 1H), 7.09 (dd, J = 8.9, 3.0 Hz, 1H), 6.94 (d, J = 2.5 Hz, 1H), 6.90 (d, J = 2.5 Hz, 1H), 6.37 (d, J = 8.8 Hz, 1H), 4.77 (s, 1H), 4.29 (bs, 1H), 3.98 — 3.87 (m, 4H), 3.85 — 3.79 (m, 1H), 3.77 (s, 3H), 3.41 — 3.24 (m, 4H), 2.27 — 2.12 (m, 2H), 1.97 — 1.79 (m, 6H) (CDC13) 5 8.71 (d, J = 2.0 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 8.44 (s, 1H), 6.98 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 6.82 (d, J = 4.7 Hz, 1H), .56 (d, J = 30.8 Hz, 1H), 4.83 (d, J = 5.2 Hz, 1H), 4.04 (s, 2H), 3.97 — 3.84 (m, 4H), 3.44 — 3.29 (m, 4H), 2.23 (d, J = 8.2 Hz, 2H), 2.02 — 1.77 (m, 6H) (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 8.16 (s, 2H), 7.00 — 6.84 (m, 2H), 5.32 (s, 1H), 4.81 (s, 1H), 208 4.03 (s, 1H), 3.96 — 3.85 (m, 4H), 3.43 — 3.32 (m, 4H), 2.49 (q, J = 7.6 Hz, 2H), 2.21 (d, J = 8.8 Hz, 2H), 2.06 — 1.75 (m, 6H), 1.21 (t, J = 7.6 Hz, 3H) (CDC13) 3 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.18 (s, 2H), 7.01 — 6.88 (m, 2H), 5.30 (d, J = 9.0 Hz, 1H), 4.81 (d, J = 5.9 Hz, 1H), 4.02 (s, 1H), 3.96 — 3.85 (m, 4H), 3.42 = — 3.29 (m, 4H), 2.78 (p, J 6.9 Hz, 1H), 2.31 — 2.14 (m, 2H), 2.01 — 1.83 (m, 6H), 1.25 H NMR (300 MHz, unless ngd Compound ure indicated otherwise) ' NMR peaks given as 8 values (400 MHz, methanol—d4) 5 8.69 (d, J = 2.0 Hz, 1H), 8.57 (d, J = 2.0 Hz, 1H), 7.92 (d, J = 6.2 Hz, 1H), 7.17 - 7.10 (m, 2H), 7.02 (d, J = 7.1 Hz, 1H), 6.90 (d, J = 2.5 Hz, 1H), 4.93 (s, 1H), 3.93 — 3.87 (m, 4H), 3.84 — 3.79 (m, 1H), 3.44 — 3.37 (m, 4H), 2.24 - 2.15 (m, 2H), 1.97 — 1.82 (m, 6H) 213 OYO’ 434.15 N / E J N6} (400 MHz, CDC13) 5 8.98 — ,0;0 N 8.83 (m, 1H), 8.79 — 8.67 (m, 1H), 8.64 — 8.50 (m, 1H), 8.35 HN (d, J = 9.2 Hz, 1H), 7.04 — 6.86 214 N 474.12 N / (m, 2H), 6.75 (d, J = 9.0 Hz, \ E 1 2H), 4.78 (s, 1H), 4.00 — 3.79 0 (m, 5H), 3.42 _ 3.21 (m, 4H), 2.17—2.11(m, 2H), 2.02—1.81 N/ NH ‘NZNI (m, 6H) H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.25 (d, J = 0.9 Hz, 1H), 6.93 (dd, J = 17.1, 2.5 Hz, 2H), 5.64 (d, J = 0.9 Hz, 1H), 5.00 (d, J = 8.1 Hz, 1H), 4.80 (dq, J = 5.5, 2.7 Hz, 1H), 4.33 (q, J = 7.1 Hz, 2H), 3.97 — 3.87 (m, 4H), 3.71 (s, 1H), 3.38 — 3.29 (m, 4H), 2.27 - 2.14 (m, 2H), 2.03 — 1.80 (m, 6H), 1.37 (t, J = 7.1 Hz, 3H) ) 3 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 6.95 (d, J = 2.5 Hz, 1H), 6.90 (d, J = 2.5 Hz, 1H), 0.23 — 0.16 (m, 0H), 4.93 (s, 1H), 4.76 (s, 1H), 4.19 — 4.01 (m, 1H), 3.97 — 3.87 (m, 4H), 3.38 — 3.29 (m, 4H), 2.49 (s, 3H), 2.26 (s, 3H), 2.21 = — 2.10 (m, 2H), 2.05 (d, J 1.8 Hz, 3H), 2.00 — 1.85 (m, (400 MHz, CDC13) 8 8.69 (d, J =19 Hz, 1H), 8.61 (d, J: 1.9 Hz, 1H), 8.15 (d, J = 5.3 Hz, 1H), 7.06 (dd, J = 5.4, 1.3 Hz, 1H), 7.00 (s, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.4 Hz, 1H), 5.15 (s, 1H), 4.81 (d, J = 2.5 Hz, 1H), 3.95 — 3.83 (m, 8H), 3.38 — 3.30 (m, 4H), 2.27 _ 2.16 (m, 2H), 1.97 — 1.85 (m, (CDC13) 5 8.70 (d, J = 2.0 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.17 (d, J = 0.9 Hz, 1H), 7.02 — 6.85 (m, 2H), 5.40 (s, 1H), 5.05 218 (td, J = 1.8, 0.8 Hz, 2H), 4.91 — 4.73 (m, 3H), 4.05 (s, 0H), 3.99 — 3.85 (m, 4H), 3.43 — 3.27 (m, 4H), 2.30 — 2.12 (m, 2H), 2.02 — 1.82 (m, 6H) WO 59690 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 6.96 (d, J = 2.5 Hz, 1H), 6.89 (d, J = 2.5 Hz, 1H), 6.03 (s, 1H), 5.00 (s, 1H), 4.79 (s, 1H), 3.92 (d, J = 9.3 Hz, 7H), 3.41 — 3.25 (m, 4H), 2.28 — 2.13 (m, (400 MHz, CDC13) 3 8.69 (s, 1H), 8.62 (s, 1H), 8.54 (s, 1H), 8.21 (d, J = 4.9 Hz, 1H), 7.22 — 7.08 (m, 2H), 6.96 (s, 1H), 6.93 (s, 1H), 4.84 (s, 1H), 3.98 — 3.86 (m, 5H), 3.38 — 3.26 (m, 4H), 2.31 — 2.19 (m, 2H), 2.03 — 1.86 (m, 6H) (400 MHz, CDC13) a 8.75 (d, J :19 Hz, 1H), 8.69 (d, J :19 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.39 (s, 1H), 8.05 (dd, J = 8.8, 2.3 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.4 Hz, 1H), 6.49 (d, J = 8.8 Hz, 1H), 5.23 (s, 1H), 4.88 — 4.71 (m, 1H), 4.05 — 3.95 (m, 1H), 3.95 — 3.85 (m, 4H), 3.39 — 3.26 (m, 4H), 2.28 — 2.16 (m, 2H), 2.00 — 1.83 m, 6H (CDC13) 3 8.63 (d, J = 1.9 Hz, 1H), 8.53 (dd, J = 1.9, 0.6 Hz, 1H), 7.71 (d, J = 9.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 6.83 (d, J = 2.5 Hz, 1H), 6.68 (d, J = 222 9.4 Hz, 1H), 5.33 (s, 1H), 4.76 (dq, J = 5.0, 2.5 Hz, 1H), 4.14 (s, 1H), 3.93 — 3.77 (m, 4H), 3.28 (d, J = 5.1 Hz, 7H), 2.18 (dt, J = 13.4, 4.6 Hz, 2H), 2.02 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 8 8.71 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 6.94 (dd, J = 15.2, 2.5 Hz, 2H), 6.07 (s, 1H), 4.82 (dt, J = 5.8, 223 3.0 Hz, 1H), 4.02 — 3.83 (m, 4H), 3.77 — 3.57 (m, 1H), 3.43 — 3.28 (m, 4H), 2.52 (s, 3H), 2.37 (s, 3H), 2.30 - 2.16 (m, 2H), 2.05 — 1.78 m, 6H ) 8 8.72 (d, J = 1.9 Hz, 1H), 8.63 (d, J =1.9 Hz, 1H), 8.27 (s, 1H), 6.98 (d, J = 2.4 Hz, 1H), 6.92 (d, J = 2.6 Hz, 224 1H), 6.44 (d, J = 6.0 Hz, 1H), 4.84 (s, 1H), 3.93 (dd, J = 6.0, 3.7 Hz, 4H), 3.43 — 3.25 (m, 4H), 2.23 (s, 2H), 2.08 — 1.83 m, 6H (CDC13) 8 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.49 (d, J = 1.1 Hz, 1H), 6.93 (dd, J = 16.7, 2.5 Hz, 2H), 6.45 (d, J = 1.2 Hz, 1H), 5.01 (s, 1H), 4.81 (s, 1H), 4.39 (d, J = 0.9 Hz, 2H), 3.97 — 3.87 (m, 4H), 3.49 (s, 3H), 3.39 — 3.29 (m, 4H), 2.22 (d, J = 9.4 Hz, 2H 1.99 — 1.87 , m, 6H (CDC13) 8 8.70 (d, J = 2.0 Hz, 1H), 8.63 (d, J =1.9 Hz, 1H), 6.95 (d, J = 2.5 Hz, 1H), 6.91 (d, J = 2.5 Hz, 1H), 4.75 (d, J = .6 Hz, 1H), 4.66 (s, 1H), 4.32 (s, 1H), 4.00 — 3.83 (m, 4H), 3.43 = — 3.22 (m, 4H), 2.46 (d, J .1 Hz, 5H), 2.36 (s, 3H), 2.19 (q, J = 6.3, 3.9 Hz, 2H), 1.12 (t, H NMR (300 MHz, unless Compound Structure ted otherwise) NMR peaks given as 8 values (CDC13) 5 8.72 (d, J = 1.9 Hz, 1H), 8.64 (d, J =19 Hz, 1H), 8.33 (d, J =18 Hz, 1H), 7.04 — 6.87 (m, 2H), 5.15 (s, 1H), 4.82 (dq, J = 5.2, 2.6 Hz, 1H), 4.24 227 (dt, J = 8.3, 4.7 Hz, 1H), 4.03 — 3.86 (m, 4H), 3.44 — 3.28 (m, 4H), 2.74 (qd, J = 7.6, 2.3 Hz, 2H), 2.24 (dq, J = 9.6, 4.6 Hz, 2H), 2.09 — 1.85 (m, 6H), 1.29 (t, J = 7.6 Hz, 3H) (CDC13) 5 8.60 (dd, J = 8.1, 1.9 Hz, 1H), 8.54 (d, J =19 Hz, 1H), 8.00 (s, 1H), 6.92 — 6.75 (m, 2H), 5.06 (d, J = 8.0 Hz, 228 1H), 4.70 (s, 1H), 3.94 (s, 1H), 3.89 — 3.76 (m, 4H), 3.75 — 3.62 (m, 4H), 3.34 — 3.17 (m, 4H), 2.50 (s, 3H), 2.11 (s, 2H), 1.82 (d, J = 5.0 Hz, 5H) (400 MHz, CDC13) 3 8.70 (d, J =19 Hz, 1H), 8.62 (d, J =19 Hz, 1H), 8.44 (d, J = 2.0 Hz, 1H), 7.91 (d, J = 8.8 Hz, 1H), 6.97 (d, J = 2.4 Hz, 1H), 6.92 229 (d, J = 2.4 Hz, 1H), 6.60 (d, J = 8.6 Hz, 1H), 5.52 (s, 1H), 4.83 (s, 1H), 4.18 (s, 3H), 4.00 — 3.87 (m, 5H), 3.39 — 3.24 (m, 4H), 2.31 — 2.18 (m, 2H), 2.04 — 1.87 (m, 6H) (400 MHz, CDC13) 8 8.81 (d, J = 1.8 Hz, 1H), 8.69 (d, J =1.9 Hz,1H), 8.61 (d, J =1.9 Hz, 1H), 8.13 (dd, J = 8.8, 2.2 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 230 6.92 (d, J = 2.4 Hz, 1H), 6.52 (d, J = 8.8 Hz, 1H), 4.82 (s, 1H), 4.36 (s, 3H), 3.96 — 3.85 (m, 5H), 3.41 - 3.28 (m, 4H), 2.28 - 2.17 (m, 2H), 2.06 — 1.83 (m, 6H) H NMR (300 MHz, unless Cmpd. ESMS Compound Structure indicated otherwise) (M+H) NMR peaks given as 8 values (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 2.0 Hz, 1H), 7.70 (d, J = 3.4 Hz, 1H), 6.93 (dd, J = 14.6, 2.5 Hz, 2H), 4.96 (dd, J = 17.8, 7.1 Hz, 2H), 4.76 (d, J = 6.2 Hz, 1H), 4.62 (ddt, J 231 510.2 = 12.6, 7.1, 3.5 Hz, 1H), 4.05 3.82 (m, 8H), 3.75 (dd, J = 9.4, 3.2 Hz, 1H), 3.40 — 3.27 (m, 4H), 2.35 (ddt, J = 13.0, 8.2, 7.1 Hz, 1H), 2.25 — 2.08 (m, 2H), 2.00 — 1.77 (m, 6H) (CDC13) a 8.61 (d, J = 1.9 Hz, 1H), 8.54 (d, J =19 Hz, 1H), 7.98 (s, 2H), 6.94 — 6.75 (m, 2H), 5.01 (s, 1H), 4.71 (d, J = .9 Hz, 1H), 3.96 — 3.78 (m, 232 477.18 5H), 3.68 (d, J = 7.0 Hz, 2H), 3.37 — 3.17 (m, 4H), 2.21 — 1.96 (m, 2H), 1.92 — 1.75 (m, 6H), 1.25 — 1.06 (m, 1H), 0.66 — 0.44 (m, 2H), 0.34 — 0.18 (m, 2H) ) 3 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =19 Hz, 1H), 8.06 (s, 2H), 7.01 — 6.86 (m, 2H), 5.00 (d, J = 8.1 Hz, 1H), 233 451.2 4.80 (d, J = 5.6 Hz, 1H), 4.10 — 3.82 (m, 7H), 3.42 — 3.26 (m, 5H), 2.20 (d, J = 8.2 Hz, 2H), 2.01 — 1.80 (m, 6H), 1.39 (t, J: 7.0 Hz, 3H) (CDC13) 5 8.72 (d, J = 1.9 Hz, 1H), 8.60 (t, J = 1.9 Hz, 2H), 6.97 (d, J = 2.5 Hz, 1H), 6.91 (d, J = 2.5 Hz, 1H), 6.70 (d, J = 234 432.17 1.2 Hz, 1H), 4.85 (d, J = 4.9 Hz, 1H), 3.98 — 3.84 (m, 4H), 3.42 — 3.26 (m, 4H), 2.33 — 2.17 (m, 2H), 2.01 — 1.77 (m, 5H) H NMR (300 MHz, unless Compound Structure ted otherwise) NMR peaks given as 8 values (CDC13) 5 8.68 (d, J = 2.0 Hz, 1H), 8.59 (d, J =19 Hz, 1H), 8.36 (s, 2H), 6.97 — 6.86 (m, 2H), 5.53 (d, J = 8.1 Hz, 1H), 4.96 — 4.72 (m, 3H), 4.09 — 3.86 (m, 5H), 3.33 (dd, J = 5.8, 4.0 Hz, 4H), 2.28 — 2.10 (m, 2H), 1.98 — 1.78 (m, 6H) (CDC13) 5 8.68 (d, J = 2.0 Hz, 1H), 8.59 (d, J =19 Hz, 1H), 8.36 (s, 2H), 6.97 — 6.86 (m, 2H), 5.53 (d, J = 8.1 Hz, 1H), 4.96 — 4.72 (m, 3H), 4.09 — 3.86 (m, 5H), 3.33 (dd, J = 5.8, 4.0 Hz, 4H), 2.28 — 2.10 (m, 2H), 1.98 — 1.78 (m, 6H) (CDC13) 5 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz,1H), 8.31 (s, 2H), 6.99 — 6.87 (m, 2H), 5.34 (d, J = 8.1 Hz, 1H), 237 4.87 — 4.73 (m, 2H), 4.06 — 3.87 (m, 6H), 3.38 — 3.29 (m, 4H), 2.20 (q, J = 5.8 Hz, 2H), 2.04 - 1.84 (m, 6H), 1.51 (d, J = 6.5 Hz, 3H) (CDC13) 8 8.71 (d, J = 1.9 Hz, 1H), 8.64 (d, J =19 Hz, 1H), 8.15 (s, 2H), 6.99 — 6.86 (m, 2H), 5.11 (td, J = 7.9, 7.4, 3.8 Hz, 1H), 4.82 — 4.55 (m, 3H), 4.10 (dd, J = 4.1, 2.7 Hz, 2H), 3.93 (dd, J = 6.0, 3.7 Hz, 5H), 3.60 — 3.43 (m, 1H), 3.36 (dd, J = 6.0, 3.7 Hz, 4H), 2.85 — 2.61 (m, 1H), 2.30 — 2.10 (m, 2H), 1.92 (s, 6H), 1.24 (q, J = 6.9 H NMR (300 MHz, unless nd Structure indicated otherwise) NMR peaks given as 8 values (CDC13) a 8.61 (d, J = 1.9 Hz, 1H), 8.54 (d, J :19 Hz, 1H), 7.95 (d, J = 13.9 Hz, 2H), 6.92 — 6.72 (m, 2H), 4.85 — 4.64 (m, 3H), 4.41 (t, J = 6.2 Hz, 2H), 3.83 (q, J = 6.7, 5.7 Hz, 6H), 3.33 — 3.18 (m, 5H), 2.20 — 1.97 (m, 1H), 1.82 (s, 7H) (CDC13) 8 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =1.9 Hz, 1H), 8.08 (s, 2H), 7.01 — 6.87 (m, 2H), 5.11 (d, J: 8.1 Hz, 1H), 4.95 = — 4.74 (m, 3H), 4.56 (t, J 6.0 Hz, 2H), 4.17 (d, J = 6.7 Hz, 2H), 4.05 - 3.81 (m, 4H), 3.51 — 3.29 (m, 5H), 2.21 (q, J = 6.4, 5.7 Hz, 2H), 2.03 — 1.80 m, 8H (400 MHz, CDC13) 8 8.69 (d, J :19 Hz, 1H), 8.61 (d, J=1.9 Hz, 1H), 7.52 (d, J = 8.7 Hz, 1H), 6.96 (d, J = 2.5 Hz, 1H), 6.90 (d, J = 2.5 Hz, 1H), 6.23 (d, J = 8.7 Hz, 1H), 5.09 (s, 1H), 4.80 (s, 1H), 4.00 — 3.78 (m, 5H), 3.40 - 3.24 (m, 4H), 2.56 (s, 3H), 2.29 - 2.14 (m, 2H 2.01 —1.80 , m, 6H (400 MHz, CDC13) 8 8.70 (d, J = 1.8 Hz, 1H), 8.62 (d, J =1.9 Hz, 1H), 8.30 (d, J =1.8 Hz, 1H), 7.37 (s, 1H), 6.96 (d, J = 2.3 Hz, 1H), 6.91 (d, J = 2.3 Hz, 1H), 4.79 (s, 1H), 4.74 (s, 1H), 4.28 (s, 1H), 4.01 — 3.83 (m, 4H), 3.40 - 3.25 (m, 4H), 2.30 — 2.17 (m, 2H), 2.11 (s, H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values ) 8 8.69 (d, J = 2.0 Hz, 1H), 8.62 (d, J :19 Hz, 1H), .36 (s, 1H), 4.03 (s, 1H), 1.57 (s, 6H), 2.02 — 1.80 (m, 6H), 243 8.42 (s, 2H), 6.99 — 6.87 (m, 2H), 4.80 (s, 1H), 3.92 (dd, J = 6.0, 3.7 Hz, 4H), 3.39 — 3.29 (m, 4H), 2.20 (d, J = 9.0 Hz, (CDC13) 5 8.98 — 8.86 (m, 2H), 8.66 (dd, J = 23.8, 1.9 Hz, 2H), 8.44 (s, 1H), 7.00 — 6.88 (m, 2H), 5.89 (d, J = 8.1 Hz, 1H), 244 4.83 (dq, J = 5.4, 2.6 Hz, 1H), 4.22 — 4.04 (m, 1H), 3.97 — 3.87 (m, 4H), 3.43 — 3.29 (m, 4H), 2.24 (td, J = 8.3, 7.4, 4.0 Hz, 2H), 2.15 — 1.81 (m, 6H) (CDC13) 8 8.61 (d, J = 1.9 Hz, 1H), 8.53 (d, J =1.9 Hz, 1H), 6.84 (dd, J = 18.2, 2.5 Hz, 2H), .26 (s, 1H), 4.78 (d, J = 8.0 245 Hz, 1H), 4.68 (d, J = 5.6 Hz, 1H), 3.82 (t, J = 4.0 Hz, 10H), 3.30 = — 3.15 (m, 4H), 2.10 (q, J 6.2, 5.7 Hz, 2H), 1.94 — 1.69 m, 6H (CDC13) 8 8.61 (d, J = 1.9 Hz, 1H), 8.54 (d, J :19 Hz, 1H), 8.06 (d, J = 5.0 Hz, 1H), 6.94 - 6.78 (m, 2H), 6.32 (d, J = 5.0 246 Hz, 1H), 5.09 (s, 1H), 4.70 (d, J = 6.0 Hz, 1H), 3.95 (s, 1H), 3.91 — 3.77 (m, 5H), 3.37 — 3.13 (m, 4H), 2.20 - 2.00 (m, 2H), 1.94 - 1.71 m, 6H H NMR (300 MHz, unless Compound Structure indicated ise) NMR peaks given as 8 values (CDC13) 5 8.71 (d, J = 1.9 Hz, 1H), 8.64 (t, J = 2.4 Hz, 1H), 8.05 (s, 2H), 7.04 — 6.87 (m, 2H), 5.20 (s, 1H), 4.80 (s, 1H), 247 4.30 (p, J = 6.1 Hz, 1H), 4.05 — 3.81 (m, 4H), 3.44 — 3.27 (m, 4H), 2.22 (t, J = 7.3 Hz, 2H), 1.93 (d, J = 4.6 Hz, 6H), 1.33 (d, J = 6.1 Hz, 6H) (400 MHz, CDC13) 5 8.69 (d, J :19 Hz, 1H), 8.66 (d, J :19 Hz, 1H), 8.62 (d, J =19 Hz, 1H), 8.05 (d, J = 8.5 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 6.51 (d, J = 8.7 Hz, 1H), 4.82 (s, 1H), 3.99 — 3.85 (m, 5H), 3.38 — 3.27 (m, 4H), 2.59 (s, 3H), 2.29 — 2.18 (m, 2H), 2.01 — 1.84 (m, 6H) (400 MHz, CDC13) 8 8.69 (d, J :19 Hz, 1H), 8.61 (d, J=1.9 Hz, 1H), 8.45 (d, J = 1.9 Hz, 1H), 7.86 (d, J = 7.7 Hz, 1H), 7.60 (d, J = 2.3 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.92 (d, J = 249 472.54 2.4 Hz, 1H), 6.50 (d, J = 2.3 Hz, 1H), 6.48 (d, J = 8.9 Hz, 1H), 4.81 (s, 1H), 3.95 — 3.85 (m, 5H), 3.39 — 3.30 (m, 4H), 2.26 - 2.17 (m, 2H), 1.99 — 1.84 (m, 6H) WO 59690 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 8 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.09 (d, J = 1.7 Hz, 1H), 7.56 — 7.45 (m, 2H), 6.96 (d, J = 2.4 Hz, 1H), 6.93 (d, J = 250 2.4 Hz, 1H), 6.55 (d, J = 8.5 Hz, 1H), 6.25 (d, J = 1.9 Hz, 1H), 4.84 (s, 1H), 3.96 — 3.83 (m, 8H), 3.39 — 3.30 (m, 4H), 2.28 — 2.19 (m, 2H), 2.03 — 1.83 (m, 6H) (CDC13) 3 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J =19 Hz, 1H), 8.18 (s, 2H), 7.04 — 6.87 (m, 2H), 5.21 (d, J = 8.2 Hz, 1H), 4.80 (s, 1H), 4.2—4.0 (m, 3H), 3.98 — 3.85 (m, 4H), 3.61 — 3.44 (m, 2H), 3.41 — 3.21 (m, 4H), 2.75 — 2.47 (m, 1H), 2.21 (d, J = 9.6 Hz, 2H), 1.92 (t, J = 6.4 Hz, 6H), 1.83 — 1.66 (m, 4H) (CDC13) 8 3.97 — 3.87 (m, 4H), 3.39 — 3.29 (m, 4H), 2.50 (s, 3H), 2.28 _ 2.16 (m, 2H), 2.02 _ 1.89 (m, 6H), 4.26 _ 4.17 (m, 1H), 8.70 (d, J =19 Hz, 1H), 8.63 (d, J =19 Hz, 1H), 7.88 (d, J = 3.3 Hz, 1H), 6.93 (dd, J = 18.7, 2.5 Hz, 2H), 5.10 (d, J = 7.9 Hz, 1H), 4.79 (d, J = 3.7 Hz, 1H (CDC13) 8 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 2.0 Hz, 1H), Nfi 8.38 (d, J = 1.1 Hz, 1H), 6.93 O N (dd, J = 17.3, 2.5 Hz, 2H), 6.18 (d, J = 1.2 Hz, 1H), 5.03 (s, 253 HN0’ 453.19 1H), 4.81 (d, J = 6.1 Hz, 1H), N 3.97 — 3.87 (m, 4H), 3.83 / (s, Nk | E 1 1H), 3.39 — 3.29 (m, 4H), 2.51 \ /CH3 (s, 3H), 2.21 (d, J = 8.8 Hz, 2H), 2.05 (s, 0H), 1.91 (d, J = .6 Hz, 6H) H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (400 MHz, CDC13) 5 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J: 1.9 Hz, 1H), 8.15 — 8.04 (m, 1H), 7.46 = — 7.39 (m, 1H), 6.97 (d, J 2.5 Hz, 1H), 6.93 (d, J = 2.5 254 Hz, 1H), 6.60 — 6.52 (m, 1H), 6.41 (d, J = 8.4 Hz, 1H), 4.80 (s, 1H), 4.68 (s, 1H), 3.98 — 3.85 (m, 5H), 3.41 — 3.30 (m, 4H), 2.27 — 2.15 (m, 2H), 1.97 — 1.86 (m, 6H) nol-d4) 5 8.71 (dd, J = 7.5, 2.1 Hz, 1H), 8.57 (dd, J = 8.8, 2.1Hz, 1H), 7.12 (d, J = 2.5 Hz, 1H), 6.88 (d, J = 2.4 Hz,1H), 3.88 (t, J = 4.8 Hz, 4H), 3.45 — 3.35 (m, 4H), 3.19 (s, 3H), 2.25 — 2.01 (m, 2H), 2.00 — 1.80 (m, 6H) (CDC13) 8 8.71 (d, J = 1.9 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 7.80 (d, J = 1.5 Hz, 1H), 7.47 (d, J =1.5 Hz, 1H), 7.02 — 6.86 256 (m, 2H), 4.80 (s, 1H), 4.27 (d, J = 8.3 Hz, 1H), 4.00 — 3.72 (m, 7H), 3.35 (dd, J = 6.0, 3.8 Hz, 4H), 2.23 (s, 2H), 2.02 — 1.80 (m, 6H) (CDC13) 8 8.71 (d, J = 1.9 Hz, 1H), 8.63 (dd, J =1.9, 0.7 Hz, 1H), 7.99 — 7.88 (m, 1H), 7.02 — 6.87 (m, 2H), 6.34 (d, J = 8.4 257 Hz, 1H), 4.78 (s, 1H), 4.40 (d, J = 8.2 Hz, 1H), 4.03 — 3.75 (m, 5H), 3.35 (dd, J = 6.0, 3.7 Hz, 4H), 2.18 (s, 5H), 2.03 — 1.81 (m, 6H) H NMR (300 MHz, unless Compound Structure indicated ise) NMR peaks given as 8 values (CDC13) 5 8.78 — 8.59 (m, 3H), 8.38 (s, 1H), 7.85 (s, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.3 Hz, 1H), 4.79 (s, 1H), 4.67 (d, J = 7.6 Hz, 1H), 4.32 (s, 1H), 3.99 — 3.82 (m, 4H), 3.40 — 3.27 (m, 4H), 2.33 — 2.06 (m, 5H), 2.03 — 1.87 (m, 6H) (CDC13) 8 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, 1H), 8.41 (s, 1H), 8.04 = — 7.93 (m, 1H), 6.96 (d, J 2.5 Hz, 1H), 6.91 (d, J = 2.1 Hz, 1H), 6.35 (d, J = 9.1 Hz, 1H), 5.07 (s, 1H), 4.82 (s, 1H), 4.02 — 3.79 (m, 5H), 3.41 — 3.27 (m, 4H), 2.83 - 2.72 (m, 3H), 2.30 — 2.17 (m, 2H), 2.02 — 1.80 (m, 6H) (CDC13) 8 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J =1.9 Hz, 1H), 6.93 (dd, J = 14.5, 2.5 Hz, 2H), 6.79 (d, J = 9.4 Hz, 1H), 6.64 (d, J = 9.4 Hz, 1H), 4.80 (d, J = 260 5.5 Hz, 1H), 4.27 (d, J = 7.5 Hz, 1H), 4.14 (s, 1H), 4.02 (s, 3H), 3.98 — 3.88 (m, 4H), 3.42 - 3.29 (m, 4H), 2.31 - 2.12 (m, 2H), 1.95 (ddd, J = 17.2, 9.2, (CDC13) 8 8.71 (d, J = 1.9 Hz, 1H), 8.64 (d, J =1.9 Hz, 1H), 8.20 (s, 2H), 7.04 — 6.84 (m, 2H), 5.16 (d, J = 8.0 Hz,1H), 4.80 (s, 1H), 4.19 — 3.85 (m, 7H), 3.66 (dd, J = 8.5, 7.1 Hz, 1H), 3.35 (dd, J = 5.9, 3.8 Hz, 4H), 3.24 (t, J = 7.5 Hz, 1H), 2.48 - 2.11 (m, 4H), 2.05 — 1.82 (m, 6H) H NMR (300 MHz, unless Compound Structure ted otherwise) NMR peaks given as 8 values (CDC13) 0 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 7.61 (d, J = 1.0 Hz, 1H), 6.98 — 6.86 (m, 2H), 4.96 (s, 1H), 4.82 - 4.71 (m, 1H), 4.63 — 4.56 (m, 1H), 4.08 — 3.87 (m, 5H), 3.38 — 3.29 (m, 4H), 2.80 (tdd, J = 6.8, .0, 3.1 Hz, 1H), 2.23 - 2.11 (m, 2H), 2.08 - 1.82 (m, 9H), 0.90 — 0.72 (m, 2H), 0.59 — 0.47 (m, 2H) (CDC13) 3 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.11 (d, J = 0.9 Hz, 1H), 6.93 (dd, J = 15.5, 2.5 Hz, 2H), 5.30 (d, J =10 Hz, 1H), 5.16 (s, 1H), 4.95 (s, 1H), —0.17 — —0.23 (m, 0H), 4.80 (s, 1H), 3.92 (dd, J = 5.9, 3.7 Hz, 4H), 3.74 (s, 1H), 3.57 (dd, J = 5.6, 4.6 Hz, 2H), 3.50 — 3.29 (m, 9H), 2.20 (d, J = 9.1 Hz, 2H), 1.93 (d, J = 13.1 Hz, 6H (CDC13) 3 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 2.0 Hz, 1H), 7.76 (d, J = 5.8 Hz, 1H), 7.02 — 6.86 (m, 2H), 5.66 (d, J = 5.9 Hz, 1H), 4.80 (d, J = 5.5 Hz, 1H), 4.63 (s, 1H), 3.97 — 3.84 (m, 5H), 1.30 — 1.20 (m, 1H), 3.64 (s, 2H), 3.38 — 3.28 (m, 4H), 1.37 (s, 6H), 5.16 — 4.86 (m, 1H), 2.24 — 2.13 (m, 2H), 1.96 —1.82 m, 6H (CDC13) 3 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.47 (d, J = 1.1 Hz, 1H), 6.93 (dd, J = 16.7, 2.5 Hz, 2H), 6.17 (t, J = 0.9 Hz, 1H), 4.95 (s, 1H), 4.81 (td, J= 5.3, 2.5 Hz, 1H), 4.07 — 3.83 (m, 5H), 3.39 — 3.29 (m, 4H), 2.34 (s, 3H), 2.21 (dt, J: 11.1, 5.1 Hz, 2H), 2.04 — 1.76 (m, 6H) H NMR (300 MHz, unless Compound ure indicated otherwise) NMR peaks given as 8 values m (CDC13) 5 11.49 (s, 1H), 8.69 (d, J = 1.9 Hz, 1H), 8.59 (d, J = 13:0, 60 N 1.9 Hz, 1H), 7.73 (d, J = 3.0 Hz, 1H), 7.03 — 6.89 (m, 2H), 266 6.56 (d, J = 7.2 Hz, 1H), 4.82 N (s, 1H), 3.91 (dd, J = 6.0, 3.8 51 [:1 Hz, 5H), 3.39 — 3.29 (m, 4H), 2.27 - 2.14 (m, 2H), 2.07 — 1.81 m, 6H (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.60 (d, J :19 Hz, 1H), 8.03 (d, J = 6.1 Hz, 1H), 6.93 (dd, J = 18.6, 2.5 Hz, 2H), 6.13 (d, J = 6.1Hz, 1H), 5.09 (s, 267 1H), 4.79 (s, 1H), 4.03 — 3.78 (m, 5H), 3.34 (dd, J = 6.0, 3.8 Hz, 4H), 2.20 (d, J = 8.1 Hz, 2H), 1.96 (s, 7H), 1.10 (d, J = 2.8 Hz, 2H), 1.00 (d, J = 8.0 Hz, 2H) (CDC13) 5 8.69 (d, J = 1.9 Hz, 1H), 8.60 (d, J =19 Hz, 1H), 7.95 (d, J = 5.8 Hz, 1H), 6.92 (dd, J = 17.9, 2.5 Hz, 2H), 5.99 268 (d, J = 5.9 Hz, 1H), 5.01 (s, 1H), 4.79 (dt, J = 6.9, 3.4 Hz, 1H), 3.91 (d, J = 8.7 Hz, 8H), 3.43 — 3.25 (m, 4H), 2.32 — 2.09 m, 2H 2.05 — 1.74 , m, 6H (CDC13) 5 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J =19 Hz, 1H), 7.70 (d, J = 6.8 Hz, 1H), 6.92 (dd, J = 14.4, 2.5 Hz, 2H), 4.86 (d, J = 8.1 Hz, 1H), 4.75 (dt, J = 8.6, 4.0 Hz, 1H), 3.97 — 3.87 (m, 5H), 3.38 — 3.28 (m, 4H), 3.14 (d, J = 2.2 Hz, 6H), 2.24 — 2.07 (m, 2H), 2.02 — 1.79 (m, H NMR (300 MHz, unless Cmpd. ESMS Compound ure indicated otherwise) (M+H) NMR peaks given as 8 values (CDC13) 8 8.71 (d, J = 1.9 Hz, 1H), 8.64 (d, J = 2.0 Hz, 1H), 8.15 (s, 2H), 7.01 — 6.87 (m, 2H), 5.13 (d, J: 8.1 Hz, 1H), 4.80 (s, 1H), 4.24 (s, 1H), 4.01 270 (s, 2H), 3.93 (dd, J = 6.0, 3.7 Hz, 4H), 3.35 (dd, J = 5.9, 3.9 Hz, 4H), 2.80 (t, J = 12.7 Hz, 2H), 2.51 (t, J = 12.1 Hz, 1H), 2.21 (d, J = 8.3 Hz, 2H), 2.05 — 1.72 (m, 8H), 1.49 (s, 9H) (CDC13) a 8.62 (d, J = 1.9 Hz, 1H), 8.55 (d, J :19 Hz, 1H), 8.09 (s, 2H), 6.93 — 6.78 (m, 2H), 5.03 (d, J = 8.1 Hz, 1H), 4.72 (d, J = 5.8 Hz, 1H), 4.02 — 3.75 (m, 5H), 3.34 — 3.21 (m, 271 z —z \_/ 490.2 / 4H), 3.20 — 3.06 (m, 2H), 2.66 (td, J = 12.1, 2.5 Hz, 2H), 2.38 (ddt, J = 12.2, 7.6, 3.8 Hz, 1H), 2.12 (d, J = 8.9 Hz, 2H), 1.96 — IZ 1.65 (m, 10H), 1.53 (qd, J = 12.3, 3.9 Hz, 2H) (CDC13) 8 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz,1H), 8.04 (d, J = 2.8 Hz, 1H), 7.94 (dd, J = 47,13 Hz,1H), 7.11 (dd, J = 8.3, 4.7 Hz, 1H), 7.00 — 272 406.53 6.84 (m, 3H), 4.78 (s, 1H), 3.98 = 8.1 — 3.88 (m, 4H), 3.85 (d, J Hz, 1H), 3.38 - 3.28 (m, 4H), 2.27 - 2.15 (m, 2H), 1.97 — 1.84 (m, 6H) H NMR (300 MHz, unless nd Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 5 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.18 (d, J = 6.3 Hz, 2H), 6.96 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 6.51 — 6.42 (m, 2H), 4.79 (s, 1H), 4.47 (d, J = 7.7 Hz, 1H), 3.98 — 3.86 (m, 4H), 3.56 (s, 1H), 3.39 — 3.26 (m, 4H), 2.27 — 2.15 (m, 2H), 2.01 — 1.79 (m, 6H) (CDC13) 5 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.18 (s, 2H), 7.03 — 6.86 (m, 2H), 5.11 (d, J: 8.1 Hz, 1H), 4.81 (d, J = 5.9 Hz, 1H), 4.12 — 3.84 (m, 5H), 3.42 — 3.29 (m, 4H), 3.05 — 2.89 (m, 2H), 2.33 (s, 4H), 2.21 (d, J = 8.8 Hz, 2H), 2.11 — 1.61 (m, 10H) (CDC13) 5 8.62 (d, J = 1.9 Hz, 1H), 8.54 (d, J :19 Hz, 1H), 6.93 — 6.77 (m, 2H), 5.20 (s, 1H), 4.78 — 4.60 (m, 2H), 3.92 — 3.79 (m, 5H), 3.64 (s, 0H), 3.51 (t, J: 5.1 Hz, 4H), 3.36 — 3.16 (m, 4H), 2.40 (t, J = 5.1 Hz, 4H), 2.27 (d, J = 4.8 Hz, 6H), 2.16 —2.02 (m, 2H), 1.81 (q, J: 8.1, 5.7 Hz, 6H (CDC13) 5 8.69 (d, J = 1.8 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 6.94 (d, J = 2.3 Hz, 1H), 6.90 (d, J = 2.3 Hz, 1H), 5.87 (s, 1H), 5.13 (s, 1H), 4.76 (s, 1H), 4.04 (s, 1H), 3.98 — 3.89 (m, 4H), 3.87 (s, 3H), 3.41 — 3.23 (m, 4H), 2.25 (s, 3H), 2.23 — 2.09 (m, 2H), 1.99 — 1.80 (m, WO 59690 H NMR (300 MHz, unless Compound Structure indicated otherwise) NMR peaks given as 8 values (CDC13) 3 8.71 (d, J = 1.9 Hz, 1H), 8.62 (d, J =19 Hz, 1H), 8.17 (d, J = 0.9 Hz, 1H), 6.94 (dd, J = 15.8, 2.5 Hz, 2H), 5.31 (s, 1H), 4.83 (dp, J = 4.6, 2.5 Hz, 1H), 4.22 (qt, J = 8.5, 4.9 Hz, 1H), 4.03 — 3.87 (m, 4H), 3.39 — 3.29 (m, 4H), 2.25 (td, J = 7.9, 6.6, 3.9 Hz, 2H), 2.09 1.80 (m, 6H) (400 MHz, CDC13) 3 8.83 (d, J = 2.2 Hz, 1H), 8.69 (d, J :19 Hz, 1H), 8.61 (d, J =19 Hz, 1H), 8.02 (dd, J = 8.8, 2.3 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.5 Hz, 1H), 6.45 (d, J = 8.9 Hz, 1H), 5.12 (s, 1H), 4.81 (d, J = 2.6 Hz, 1H), 3.98 (s, 1H), 3.95 — 3.87 (m, 4H), 3.40 — 3.26 (m, 5H), 2.42 (s, 3H), 2.29 — 2.16 (m, 2H), 1.99 — 1.87 (m, 6H) (CDC13) 5 8.69 (d, J = 1.9 Hz, 1H), 8.60 (d, J = 2.0 Hz, 1H), 7.21 — 7.11 (m, 1H), 7.00 — 6.85 (m, 2H), 5.51 (s, 1H), 4.95 — 279 4.70 (m, 2H), 4.53 — 4.34 (m, 1H), 4.01 — 3.74 (m, 5H), 3.45 — 3.25 (m, 4H), 2.25 — 2.09 (m, 2H), 2.03 — 1.73 (m, 6H), 1.39 — 1.25 (m, 3H) (methanol—d4) 5 8.68 (d, J = 2.0 Hz, 1H), 8.54 (d, J = 2.0 Hz, 1H), 7.30 (d, J = 7.2 Hz, 1H), 7.10 (d, J = 2.4 Hz, 1H), 6.87 (d, J = 2.4 Hz, 1H), 5.79 (d, J = 7.2 Hz, 1H), 4.13 (qd, J = 8.5, 6.7, 2.4 Hz, 1H), 3.87 (dd, J = .9, 3.8 Hz, 4H), 3.42 — 3.32 (m, 5H), 2.21 — 2.07 (m, 2H), 2.01 — 1.78 m, 6H H NMR (300 MHz, unless Compound Structure indicated ise) NMR peaks given as 8 values (400 MHz, CDC13) 8 8.68 (d, J = 1.9 Hz, 1H), 8.61 (d, J= 1.9 Hz, 1H), 8.18 (d, J = 2.2 Hz, 1H), 7.58 (dd, J = 8.7, 2.5 Hz, 1H), 6.95 (d, J = 2.5 Hz, 1H), 6.91 (d, J = 2.4 Hz, 1H), 6.39 (d, J = 8.8 Hz, 1H), 4.78 (s, 1H), 4.69 (s, 1H), 3.96 — 3.83 (m, 5H), 3.49 (s, 1H), 3.38 — 3.28 (m, 4H), 2.26 — 2.13 (m, 2H), 1.95 — 1.84 (m, 6H), 1.56 (s, 6H) (CDC13) 5 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J =19 Hz, 1H), 7.93 — 7.74 (m, 2H), 7.04 — 6.82 (m, 2H), 4.80 (s, 1H), 4.50 (d, J 282 = 8.1 Hz, 1H), 3.93 (dd, J = 6.4, 3.4 Hz, 5H), 3.41 — 3.25 (m, 4H), 2.51 — 2.33 (m, 3H), 2.23 (s, 2H), 2.04 — 1.82 (m, (CDC13) 3 8.62 (d, J = 1.9 Hz, 1H), 8.55 (d, J =19 Hz, 1H), 7.88 (dd, J = 5.3, 0.7 Hz, 1H), 6.95 — 6.79 (m, 2H), 6.32 (ddd, J = 5.2, 1.5, 0.7 Hz, 1H), 6.12 (dt, J = 1.6, 0.8 Hz, 1H), 4.71 (d, J = 5.9 Hz, 1H), 4.40 (d, J = 8.2 Hz, 1H), 3.98 — 3.67 (m, 4H), 3.35 — 3.17 (m, 4H), 2.15 (s, 4H), 1.83 (d, J = 5.2 Hz, 5H) (CDC13) a 8.62 (d, J = 1.9 Hz, 1H), 8.54 (d, J =19 Hz, 1H), 6.86 (dd, J = 16.6, 2.5 Hz, 2H), .97 (d, J =12 Hz, 1H), 5.02 284 (s, 1H), 4.71 (dt, J = 5.7, 3.0 Hz, 1H), 3.91 — 3.75 (m, 4H), 3.63 — 3.42 (m, 1H), 3.33 — 3.17 (m, 4H), 2.21 — 2.03 (m, 5H), 1.94 — 1.71 m, 6H H NMR (300 MHz, unless ESMS Compound Structure indicated ise) (M+H) NMR peaks given as 8 values (400 MHz, CDC13) 5 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J: 1.9 Hz 1H) 8.08 (d J = 5.7 Hz N /fiIN 7 7 7 7 0 1H), 6.96 (d, J = 2.4 Hz, 1H), 0’ 6.90 (d, J = 2.4 Hz, 1H), 6.30 (s, 1H), 6.28 (dd, J = 5.7, 2.2 285 ”N 42057 Hz, 1H), 4.78 (s, 1H), 4.19 (d, J / = 7.7 Hz, 1H), 3.97 — 3.82 (m, | 1 4H), 3.53 (s, 1H), 3.40 — 3.24 N CH3 0 (m, 4H), 2.41 (s, 3H), 2.27 — 2.11 (m,2H), 1.92 _ 1.84 (m, (400 MHz, CDC13) 8 8.69 (d, J m =19 Hz N / 7 1H) 8.60 (d J =19 7 7 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 286 “N0’0 6.15 (s, 2H), 4.77 (s, 1H), 4.12 43456 (d, J = 7.8 Hz, 1H), 3.99 — 3.81 l E 1 (m, 4H), 3.53 (s, 1H), 3.40 — 3.23 (m, 4H), 2.36 (d, J = 14.5 CH3 0 Hz, 6H), 2.25 — 2.14 (m, 2H), 1.89 (t, J: 7.8 Hz, 6H) WO 59690 Compound H NMR 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.33 (s, 1H), 6.94 (dd, J = 14.3, 2.5 Hz, 2H), .80 (d, J = 4.9 Hz, 1H), 5.42 287 (d, J = 8.1 Hz, 1H), 4.88 - 4.74 (m, 1H), 4.08 (s, 2H), 3.99 - 3.86 (m, 4H), 3.50 (s, 3H), 3.42 - 3.28 (m, 4H), 3.01 (dd, J = 18.4, 5.0 Hz, 3H), 2.54 (s, 3H), 2.28 - 2.08 (m, 2H), 2.03 - 1.79 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.68 (t, J = 5.2 Hz, 1H), 8.65 (d, J = 1.7 Hz, 1H), 8.02 (d, J = 5.9 Hz, 1H), 7.26 (d, J = 1.5 Hz, 1H), 7.08 (d, J =1.6 Hz, 1H), 7.00 (d, J =1.6 Hz, 1H), 6.07 (d, J = 6.0 Hz, 1H), 4.91 (s, 1H), 4.75 (s, 1H), 4.54 (t, J = 9.6 Hz, 2H), 3.03 (td, J = 9.8, 1.6 Hz, 2H), 2.42 (s, 3H), 2.21 — 2.06 (m, 2H), 1.91 — 1.74 (m, 7H). 1H NMR (400 MHz, CDCI3) 5 8.79 — 8.71 (m, 2H), 8.03 (d, J = 5.8 Hz, 1H), 7.39 (s, 1H), 6.38 (s, 1H), 6.08 (d, J = 5.9 289 Hz, 1H), 5.06 (s, 2H), 4.83 (d, J = 29.0 Hz, 4H), 2.42 (s, 3H), 2.16 (d, J = 7.2 Hz, 2H), 1.88 (dd, J = 21.2, 8.7 Hz, 6H), 1.58 (s, 2H). 2014/024767 Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (400 MHz, CDCI3) 6 8.62 (d, J = 1.9 Hz, 1H), 8.53 (d, J = 1.9 Hz, 1H), 8.03 (d, J = 5.9 Hz, 1H), 6.88 (td, J = 19.2, 3.6 Hz, 2H), 6.07 (d, J = 6.0 Hz, 1H), 4.87 (s, 1H), 4.74 (s, 1H), 4.06 — 3.93 (m, 1H), 3.80 — 3.69 (m, 2H), 3.58 — 3.38 (m, 2H), 2.94 (td, J = 11.9, 3.5 Hz, 1H), 2.65 — 2.52 (m, 1H), 2.42 (s, 3H), 2.13 (d, J = 10.1 Hz, 2H), 1.81 (d, J = 9.7 Hz, 6H), 1.32 — 1.08 (m, 3H . 1H NMR (400 MHz, Chloroform-d) 6 8.42 (d, J = 1.9 Hz, 1H), 8.30 (d, J = 1.9 Hz, 1H), 8.04 (d, J = 4.8 Hz, 2H), 6.65 - 6.56 (m, 2H), 6.28 (t, J = 4.8 Hz, 1H), 4.99 (d, J = 8.1 Hz, 1H), 4.60 (d, J = 6.5 Hz, 3H), 3.79 (dd, J = 8.2, 4.0 Hz, 0H), 3.62 - 3.38 (m, 4H), 3.17 - 3.03 (m, 1H), 2.07 - 1.90 (m, 2H), 1.89 - 1.59 (m, 7H). 1H NMR (400 MHz, CDCI3) 6 8.83 (dd, J = 2.3, 0.8 Hz, 1H), 8.77 — 8.68 (m, 2H), 8.54 (dd, J = 4.8, 1.6 Hz, 1H), 7.95 (d, J = 6.0 Hz, 1H), 7.86 (ddd, J = 7.9, 2.4, 1.6 Hz, 1H), 7.76 (d, 292 J = 1.7 Hz, 1H), 7.31 (ddd, J = 7.9, 4.8, 0.8 Hz, 1H), 7.21 (d, J =1.6 Hz, 1H), 7.11 (d, J = 0.9 Hz, 1H), 6.00 (d, J = 6.0 Hz, 1H), 4.80 (d, J = 27.2 Hz, 2H), 2.34 (s, 3H), 2.18 — 2.04 (m, 2H), 1.84 — 1.71 (m, 6H). 2014/024767 Compound ESMS H NMR C d St t 1H NMR (400 MHz, CDCI3) 5 11.20 (s, 1H), 8.74 (t, J = 6.1 Hz, 1H), 8.71 (d, J :18 Hz, 1H), 8.03 (d, J = 5.9 Hz, 1H), 7.96 (s, 2H), 7.75 (t, J = 8.0 293 Hz, 1H), 7.26 (d, J = 1.5 Hz, 1H), 6.08 (d, J = 6.0 Hz, 1H), .09 (s, 1H), 4.82 (s, 1H), 3.77 (s, 1H), 2.43 (s, 3H), 2.24 — 2.08 (m, 2H), 1.93 — 1.76 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.10 (d, J = 6.0 Hz, 1H), 7.36 - 7.28 (m, 1H), 6.65 (d, J = 2.0 Hz, 1H), 6.13 (d, J = 6.0 Hz, 1H), 4.81 (d, J = 8.0 Hz, 1H), 4.00 - 3.80 (m, 6H), 3.80 - 3.56 (m, 1H), 3.29 (dd, J = 5.8, 3.8 Hz, 4H), 3.02 - 2.84 (m, 2H), 2.48 (s, 3H), 2.36 (td, J = 11.4, 10.9, 2.5 Hz, 2H), 2.14 - 1.98 (m, 2H), 1.70 - 1.46 (m, 2H). 1H NMR (300 MHz, Chloroform-d) 6 8.98 - 8.78 (m, 2H), 8.33 (d, J = 1.9 Hz, 1H), 7.67 (d, J = 1.8 Hz, 1H), 7.30 (d, J :18 Hz, 1H), 6.49 - 6.31 (m, 1H), 5.07 (d, J = 7.6 Hz, 1H), 4.87 (d, J = 5.5 Hz, 1H), 4.43 (q, J = 2.8 Hz, 2H), 4.24 (s, 1H), 4.02 (t, J = 5.4 Hz, 2H), 2.71 (dtd, J = 13.1, 7.7, 2.7 Hz, 4H), 2.26 (dt, J = .4, 5.3 Hz, 2H), 1.97 (d, J = .3 Hz, 6H), 1.28 (t, J = 7.6 Hz, 3H .

Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.79 - 8.67 (m, 1H), 8.64 (d, J :19 Hz, 1H), 6.93 (dd, J = 13.0, 2.6 Hz, 2H), 4.77 (s, 1H), 3.94 (q, 296 550.6 J = 6.6, 5.0 Hz, 5H), 3.35 (t, J = 4.8 Hz, 4H), 2.16 (d, J = 33.6 Hz, 2H), 1.86 (mJ = 4.9 , 1.51 (q, J = 20,16 Hz, 9H). 1H NMR (400 MHz, CDCI3) 6 8.60 (d, J = 1.9 Hz, 1H), 8.49 (d, J :19 Hz, 1H), 8.02 (d, J = 6.0 Hz, 1H), 6.78 (dd, J = .1, 2.5 Hz, 2H), 6.08 (d, J = 6.0 Hz, 1H), 4.96 (s, 1H), 4.74 (d, J = 2.4 Hz, 1H), 4.49 (d, J = 2.3 Hz, 2H), 3.41 (t, J = 5.4 Hz, 2H), 3.12 (dd, J = 11.6, 2.5 Hz, 2H), 2.43 (s, 3H), 2.14 (dd, J = 9.6, 4.9 Hz, 2H), 1.98 — 1.68 (m, 10H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.65 (d, J :19 Hz, 1H), 7.53 (dt, J = 81,10 Hz, 1H), 7.35 (ddd, J = 8.1, 6.8, 1.1 Hz, 1H), 7.20 (dt, J = 8.5, 0.9 Hz, 1H), 7.07 - 6.89 (m, 3H), 4.79 (td, J = 6.1, 3.1 Hz, 1H), 4.02 - 3.91 (m, 4H), 3.87 (s, 3H), 3.43 - 3.25 (m, 4H), 2.34 - 2.15 (m, 2H), 2.10 - 1.88 (m, 6H).

WO 59690 Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 7.02 - 6.89 (m, 2H), 6.57 (d, J = 1.0 Hz, 1H), 4.87 - 299 4.76 (m, 1H), 4.76 - 4.62 (m, 1H), 4.09 - 3.88 (m, 5H), 3.45 - 3.25 (m, 4H), 2.65 (d, J = 0.8 Hz, 3H),2.56(s, 3H), 2.31 - 2.12 (m, 2H), 2.09 - 1.81 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.71 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 8.13 (d, J = 5.9 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.85 (d, J = 2.4 Hz, 1H), 6.13 (d, J = 6.0 Hz, 1H), 300 5.17 (s, 1H), 4.50 (s, 1H), 4.29 (d, J = 6.7 Hz, 2H), 4.03 — 3.82 (m, 4H), 3.45 — 3.32 (m, 4H), 3.04 — 2.93 (m, 1H), 2.58 — 2.50 (m, 2H), 2.49 (s, 3H), 2.24 (ddd, J = 20.4, 10.3, 6.0 Hz, 2H). 1H NMR (400 MHz, CDCI3) 5 8.76 (s, 2H), 8.09 (d, J = 5.7 Hz, 1H), 6.94 (d, J = 2.3 Hz, 1H), 6.80 (d, J = 2.2 Hz, 1H), 6.73 (s, 1H), 6.19 (d, J = 5.1 Hz, 1H), 4.35 (s, 1H), 4.17 (d, J = 3.9 Hz, 2H), 4.03 — 3.77 (m, 4H), 3.45 — 3.21 (m, 4H), 2.85 (dd, J = 19.9, 9.1 Hz, 2H), 2.80 — 2.70 (m, 1H), 2.51 (s, 3H), 2.06 (dt, J = 12.7, 6.4 Hz, 2H).

WO 59690 Compound ESMS H NMR 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 8.13 (d, J = 5.8 Hz, 1H), 6.92 (d, J = 2.4 Hz, 1H), 6.55 (d, J = 2.4 Hz, 1H), 6.18 (d, J = 6.0 Hz, 1H), 302 I1H NMR (400 MHz, CDCI3) 5 5.07 — 4.97 (m, 1H), 4.91 (s, 1H), 3.99 — 3.82 (m, 4H), 3.50 (d, J = 5.5 Hz, 1H), 3.38 — 3.23 (m, 4H), 2.72 (dd, J = 8.1, 4.8 Hz, 1H), 2.65 (dt, J = 15.2, 7.7 Hz, 2H), 2.51 (s, 3H), 2.45 (ddd, J = 11.1, 6.8, 3.4 Hz, 2H).

I1H NMR (400 MHz, CDCI3) 5 8.71 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 8.10 (d, J = 5.8 Hz, 1H), 6.92 (d, J = 2.4 Hz, 1H), 6.67 (d, J = 2.4 Hz, 1H), 6.15 (d, J = 6.0 Hz, 1H), 4.95 (s, 1H), 4.79 (p, J = 7.1 Hz, 1H), 3.98 — 3.83 (m, 4H), 3.45 (bt, 2H), 3.36 — 3.27 (m, 4H), 2.79 (dtd, J = 9.8, 7.2, 2.8 Hz, 2H), 2.48 (s, 3H), 2.38 (dt, J = 16.0, 8.0 Hz, 1H), 2.19 (ddd, J = 17.0, 9.7, 2.8 Hz, 2H). 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.61 m (d, J = 1.9 Hz, 1H), 8.27 (d, J = 4.8 Hz, 2H), 6.93 (d, J = 2.4 i fw‘xe Hz, 1H), 6.85 (d, J = 2.4 Hz, . “if f, . N N w \ 1H), 6.54 (t, J = 4.8 Hz, 1H), 304 H i 393.21 5.36 (d, J = 7.2 Hz, 1H), 4.70 — \ x”j 4.58 (m, 1H), 4.31 (d, J = 7.7 N R Hz, 2H), 4.01 — 3.86 (m, 4H), w 3.44 — 3.30 (m, 4H), 3.04 — 2.93 (m, 1H), 2.50 (ddd, J = 13.5, 7.8, 3.1 Hz, 2H), 2.31 — 2.19 (m, 2H). 2014/024767 Compound ESMS H NMR Compound Structure 1H NMR (400 MHz, CDCI3) 5 8.81 (d, J = 1.9 Hz, 1H), 8.74 (d, J = 1.9 Hz, 1H), 8.29 (d, J = 4.8 Hz, 2H), 6.93 (d, J = 2.4 Hz, 1H), 6.80 (d, J = 2.4 Hz, 1H), 6.64 (d, J = 8.5 Hz, 1H), 305 6.50 (t, J = 4.8 Hz, 1H), 4.60 (dq, J = 15.6, 7.6 Hz, 1H), 4.19 (d, J = 4.6 Hz, 2H), 4.01 — 3.84 (m, 4H), 3.43 — 3.27 (m, 4H), 2.88 — 2.78 (m, 2H), 2.78 — 2.68 (m, 1H), 2.08 — 1.97 (m, 2H). 1H NMR (400 MHz, CDCI3) 5 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 8.29 (d, J = 4.8 Hz, 2H), 6.91 (d, J = 2.4 Hz, 1H), 6.63 — 6.51 (m, 2H), 306 5.21 (s, 1H), 5.03 (p, J = 6.6 Hz, 1H), 4.02 — 3.79 (m, 4H), 3.63 (dd, J = 7.3, 5.9 Hz, 2H), 3.42 — 3.19 (m, 4H), 2.79 — 2.68 (m, 1H), 2.68 — 2.54 (m, 2H), 2.52 — 2.40 (m, 2H). 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.8 Hz, 1H), 8.61 (d, J = 1.8 Hz, 1H), 8.26 (d, J = 4.8 Hz, 2H), 6.91 (d, J = 2.0 Hz, 1H), 6.68 (d, J = 2.1 Hz, 1H), 6.53 (t, J = 4.8 Hz, 1H), 307 5.19 (s, 1H), 4.76 (p, J = 7.2 Hz, 1H), 3.99 — 3.79 (m, 4H), 3.56 (t, J = 6.4 Hz, 2H), 3.41 — 3.23 (m, 4H), 2.77 (dt, J = 9.7, 7.3 Hz, 2H), 2.39 (dt, J = 16.5, 8.3 Hz, 1H), 2.19 (dd, J = 19.6, 9.7 Hz, 2H).

WO 59690 Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 7.79 (s, 1H), 7.23 (s, 1H), 6.95 (dd, J = 14.0, 2.5 Hz, 2H), 5.23 (d, J = 8.1 Hz, 1H), 4.80 (s, 1H), 4.09 (s, 1H), 3.94 (dd, J = 6.1, 3.6 Hz, 4H), 3.43 - 3.23 (m, 4H), 3.02 (d, J = 5.1 Hz, 3H), 2.43 (s, 3H), 2.31 - 2.12 (m, 2H), 1.95 (p, J = 10.0 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.68 (d, J = 1.9 Hz, 1H), 8.54 (d, J :19 Hz, 1H), 6.85 (s, 2H), 6.30 (s, 1H), 5.06 (d, J = 16.2 Hz,1H), 4.85 (d, J = 6.5 Hz, 3H), 4.44 - 4.30 (m, 2H), 4.14 (q, J = 7.1 Hz, 1H), 3.89 - 3.60 (m, 5H), 3.50 (s, 3H), 3.35 (q, J = 7.2 Hz, 1H), 2.49 (s, 3H), 2.24 (d, J = 8.7 Hz, 2H), 2.08 (d, J = 7.7 Hz, 2H), 1.92 (q, J = 9.6, 6.9 Hz, 6H), 1.28 (t, J = 7.1 Hz, 2H . 1H NMR (300 MHz, CDCI3) 6 8.72 (d, J = 1.8 Hz, 1H), 8.66 (d, J =19 Hz, 1H), 7.35 (d, J = 4.3 Hz, 1H), 7.17 (d, J = 4.8 Hz, 1H), 6.97 (dd, J = 12.0, 2.2 Hz, 2H), 4.92 (s, 1H), 4.35 (s, 1H), 4.01 — 3.84 (m, 4H), 3.48 — 3.26 (m, 4H), 2.72 (s, 3H), 2.36 — 2.21 (m, 2H), 2.13 — 1.85 (m, 6H).

WO 59690 Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (300 MHz, CDCI3) 5 8.71 (d, J = 1.9 Hz, 1H), 8.65 (d, J = 1.9 Hz, 1H), 7.57 (d, J = 3.2 Hz, 1H), 7.35 — 7.28 (m, 2H), 6.97 (d, J = 2.4 Hz, 1H), 312 6.91 (d, J = 2.4 Hz, 1H), 5.23 (s, 1H), 4.76 (s, 1H), 4.20 (s, 1H), 4.01 (s, 3H), 3.98 — 3.84 (m, 4H), 3.44 — 3.29 (m, 4H), 2.27 — 2.14 (m, 2H), 2.05 — 1.85 (m, 6H). 1H NMR (300 MHz, CDCI3) 5 8.68 (dd, J = 21.2, 1.9 Hz, 2H), 7.86 (s, 1H), 7.18 (d, J = 4.9 Hz, 1H), 7.00 (d, J = 4.9 Hz, 1H), 6.96 (dd, J = 12.1, 2.4 Hz, 2H), 5.18 (d, J = 7.4 Hz, 1H), 4.80 (s, 1H), 4.30 (dd, J = 11.9, 6.0 Hz, 1H), 4.05 — 3.77 (m, 4H), 3.45 — 3.14 (m, 4H), 2.75 (s, 3H), 2.37 — 2.14 (m, 2H), 2.14 — 1.87 (m, 6H).

Compound ESMS H NMR “d St“‘6 ”ret 1H NMR (300 MHz, CDCI3) 6 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 7.66 (s, 1H), 6.94 (dd, J = 14.9, 2.4 Hz, 2H), 4.84 — 4.74 (m, 1H), 4.47 (s, 1H), 4.02 — 3.87 (m, 4H), 3.87 — 3.75 (m, 1H), 3.47 — 3.21 (m, 4H), 2.38 (d, J = 4.0 Hz, 6H), 2.26 — 2.13 (m, 2H), 2.01 — 1.78 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.68 (d, J = 1.9 Hz, 1H), 8.59 - 8.46 (m, 2H), 7.98 (s, 1H), 7.18 (s, 1H), 6.85 (s, 2H), 4.85 (d, J = 6.6 Hz, 2H), 3.90 - 3.62 (m, 5H), 3.35 (d, J = 8.2 Hz, 1H), 3.03 (d, J = 5.1 Hz, 3H), 2.27 (s, 2H), 2.13 - 1.80 (m, 7H), .58(s, 2H) 1H NMR (300 MHz, Chloroform-d) 6 8.14 (d, J = 6.2 Hz, 1H), 6.50 (d, J = 1.7 Hz, 1H), 6.43 (d, J = 1.6 Hz, 316 1H), 6.21 (d, J = 6.2 Hz, 1H), 4.98 (s, 1H), 4.01 - 3.81 (m, 5H), 3.37 - 3.18 (m, 5H), 2.54 (s, 3H), 2.20 (d, J = 9.1 Hz, 3H), 2.05 - 1.71 (m, 6H).

WO 59690 Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.68 (d, J = 1.9 Hz, 1H), 8.62 - 8.41 (m, 2H), 7.79 (s, 1H), 7.33 (d, J = 4.9 Hz, 1H), 6.85 (q, J = 2.6 317 Hz, 3H), 4.85 (d, J = 6.3 Hz, 4H), 4.08 (s, 0H), 3.88 - 3.58 (m, 5H), 3.35 (q, J = 6.8 Hz, 1H), 3.03 (d, J = 5.1 Hz, 3H), 2.36 - 2.13 (m, 2H), 2.15 - 1.84 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.68 (d, J = 1.9 Hz, 1H), 8.56 (d, J :19 Hz, 1H), 8.33 (d, J :19 Hz, 1H), 6.85 (s, 2H), 5.07 (d, J = 8.1 Hz, 1H), 4.86 (d, J = 6.4 Hz, 4H), 4.23 (s, 2H), 3.90 - 3.62 (m, 4H), 3.35 (q, J = 7.1 Hz, 1H), 2.73 (qd, J = 7.6, 2.3 Hz, 2H), 2.27 (d, J = 10.1 Hz, 3H), 2.12 - 1.82 (m, 6H), 1.28 (t, J = 7.6 Hz, 3H). 1H NMR (300 MHz, Chloroform-d) 6 8.83 (dt, J = 6.4, 1.4 Hz, 2H), 8.51 (d, J = 4.7 Hz, 1H), 7.78 (s, 1H), 7.68 (d, J = 1.7 Hz, 1H), 7.34 (dd, J = 4.9, 0.9 Hz, 1H), 6.38 (s, 319 1H), 5.32 (d, J = 0.9 Hz, 1H), 4.87 (s, 1H), 4.43 (q, J = 2.8 Hz, 2H), 4.17 - 3.94 (m, 3H), 3.03 (dd, J = 51,10 Hz, 3H), 2.76 - 2.59 (m, 2H), 2.23 (d, J = 12.7 Hz, 2H), 1.98 (d, J = 7.7 Hz, 6H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.10 (d, J = 6.0 Hz, 1H), 6.97 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.6 Hz, 1H), 6.15 (d, J = 6.0 Hz, 1H), 4.99 (s, 1H), 4.81 (s, 1H), 4.19 - 4.08 (m, 1H), 3.94 - 3.69 (m, 5H), 3.63 (t, J = 11.3 Hz, 2H), 3.04 (td, J = 11.9, 3.5 Hz, 1H), 2.92 - 2.80 (m, 1H), 2.50 (s, 3H), 2.20 (d, J = 8.9 Hz, 2H), 1.90 d, J = 5.6 Hz, 7H. 1H NMR (300 MHz, form-d) 6 8.81 - 8.67 (m, 2H), 8.42 (s, 1H), 7.89 (s, 1H), 7.58 (d, J = 1.8 Hz, 1H), 7.09 (s, 1H), 6.28 (dq, J = 3.0, 321 1.6 Hz, 1H), 4.81 (s, 1H), 4.33 (q, J = 2.8 Hz, 2H), 3.92 (t, J = .4 Hz, 2H), 2.93 (d, J = 5.1 Hz, 3H), 2.67 - 2.48 (m, 2H), 2.18 (d, J =11.3 Hz, 2H), 1.98 - 1.73 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.62 (d, J = 1.9 Hz, 1H), 8.52 (d, J :19 Hz, 1H), 6.85 (dd, J = 18.8, 2.5 Hz, 2H), 5.59 (d, J = 8.3 322 Hz, 1H), 5.24 (s, 1H), 4.72 (s, 1H), 3.84 (t, J = 4.9 Hz, 5H), 3.66 - 3.39 (m, 3H), 3.30 - 3.19 (m, 5H), 2.78 (t, J = 7.0 Hz, 2H), 2.11 (s, 1H), 2.00 - 1.66 (m, 6H).

WO 59690 Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (300 MHz, CDCI3) 5 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 7.79 (d, J = 5.9 Hz, 1H), 6.97 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.4 Hz, 1H), 6.13 (dd, J = 5.9, 2.1 Hz, 1H), 5.87 (d, J = 2.0 Hz, 1H), 4.87 — 4.70 (m, 1H), 4.32 (q, J = 7.1 Hz, 2H), 4.21 (d, J = 7.8 Hz, 1H), 4.05 — 3.81 (m, 4H), 3.60 — 3.45 (m, 1H), 3.45 — 3.24 (m, 4H), 2.33 — 2.10 (m, 2H), 2.02 — 1.77 (m, 6H), 1.39 t,J=7.1Hz,3H. 2 1H NMR (300 MHz, CDCI3) 5 11.03 (s, 1H), 8.71 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 7.09 (d, J = 7.1 Hz, 1H), 6.97 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 5.67 (dd, J 325 = 7.2, 2.1 Hz, 1H), 5.58 (d, J = 2.1 Hz, 1H), 4.84 — 4.75 (m, 1H), 4.41 (d, J = 7.6 Hz, 1H), 4.02 — 3.87 (m, 4H), 3.54 — 3.43 (m, 1H), 3.42 — 3.27 (m, 4H), 2.28 — 2.15 (m, 2H), 2.05 — 1.78 (m, 6H). nd ESMS C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.68 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 7.01 - 6.83 (m, 2H), .34 (s, 1H), 4.73 (d, J = 6.1 423.4 Hz, 1H), 3.91 (dd, J = 6.1, 3.7 Hz, 4H), 3.59 (s, 4H), 3.44 (s, 1H), 3.33 (t, J = 4.9 Hz, 4H), 2.17 (s, 5H), 1.86 (q, J = 9.1, 6.3 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 2.0 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 8.00 (d, J = 1.3 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.5 Hz, 1H), 4.88 (d, J = 8.2 Hz, 1H), 4.77 (s, 523.35 1H), 4.63 (d, J = 9.0 Hz, 2H), 4.15 (s, 1H), 3.92 (t, J = 4.9 Hz, 4H), 3.39 - 3.26 (m, 4H), 2.91 (td, J = 8.6, 3.9 Hz, 1H), 2.72 - 2.55 (m, 2H), 2.50 - 2.10 (m, 7H), 1.91 (d, J = 5.5 Hz, 6H), 1.72 (d, J = 4.7 Hz, 1H NMR (300 MHz, Chloroform-d) 6 8.81 - 8.59 (m, 3H), 8.54 (d, J :19 Hz, 1H), 6.92 - 6.73 (m, 2H), 5.50 (d, J = 8.2 Hz, 1H), 4.72 (s, 521 .69 1H), 4.01 (s, 2H), 3.84 (t, J = 4.9 Hz, 5H), 3.50 (q, J = 5.3 Hz, 3H), 3.37 - 3.17 (m, 5H), 2.62 (t, J = 5.6 Hz, 2H), 2.34 (s, 7H), 2.13 (d, J = 10.7 Hz, 2H), 1.87 (d, J = 22.1 Hz, 6H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.62 (t, J = 1.7 Hz, 1H), 8.55 (t, J = 1.7 Hz, 1H), 8.37 (dt, J = 4.6, 1.5 Hz, 1H), 7.78 (dt, J = 7.9, 1.5 329 46044 Hz, 1H), 6.93 - 6.77 (m, 3H), 4.71 (d, J = 6.1 Hz, 1H), 3.96 - 3.77 (m, 6H), 3.33 - 3.18 (m, 4H), 2.23 - 2.07 (m, 2H), 2.01 - 1.77 (m, 6H). 1H NMR (300 MHz, form-d) 6 8.62 (d, J = 1.9 Hz, 1H), 8.53 (d, J :19 Hz, 1H), 8.10 (dd, J = 4815 Hz, 1H), 7.61 (dd, J = 8.0, 1.5 Hz, 1H), 7.12 (dd, J = 8.1, 4.8 330 4636 Hz, 1H), 6.95 - 6.76 (m, 2H), .39 (s, 1H), 4.74 (s, 1H), 3.96 - 3.75 (m, 5H), 3.26 (t, J = 4.9 Hz, 4H), 2.16 (d, J = 12.8 Hz, 2H), 2.05 - 1.71 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.62 (d, J = 1.9 Hz, 1H), 8.53 (d, J :19 Hz, 1H), 7.28 (d, J = 0.7 Hz, 1H), 6.94 - 6.77 (m, 2H), 5.39 331 4554 (s, 1H), 5.09 (d, J = 7.8 Hz, 1H), 4.71 (s, 1H), 3.93 - 3.77 (m, 4H), 3.58 (s, 1H), 3.26 (dd, J = 6.0, 3.7 Hz, 4H), 2.11 (s, 2H), 1.97 - 1.66 (m, 6H).

Compound ESMS H NMR nd Structure 2014/024767 Compound ESMS H NMR C°mp°”“d St“‘6 ”et 335 421 .37 336 446.35 1H NMR (300 MHz, Chloroform-d) 6 8.67 - 8.58 (m, 1H), 8.58 - 8.49 (m, 1H), 8.33 (s, 2H), 6.92 - 6.78 (m, 2H), 5.41 (d, J = 8.1 Hz, 1H), 337 533.2 4.72 (s, 1H), 3.98 (d, J = 8.6 Hz, 1H), 3.84 (t, J = 4.8 Hz, 4H), 3.58 (s, 4H), 3.26 (t, J = 4.9 Hz, 4H), 2.36 (t, J = 4.9 Hz, 4H), 2.25 (s, 3H), 2.13 (d, J = 10.8 Hz, 2H), 1.84 (s,6H). nd ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (300 MHz, DMSO- d6) 5 8.72 (d, J = 1.9 Hz, 1H), 8.59 (d, J = 1.9 Hz, 1H), 7.17 (d, J = 2.5 Hz, 1H), 6.84 (d, J = 2.4 Hz, 1H), 6.69 — 6.61 (m, 1H), 6.50 (m, 2H), 4.94 (m, 1H), 4.50 (t, J = 8.7 Hz, 2H), 4.27 (d, J = 8.2 Hz, 1H), 3.79 (m, 4H), 3.45 (m, 1H), 3.32 (m, 4H), 3.13 (t, J = 8.7 Hz, 2H), 1.98 (m, 2H), 1.74 (m, 6H). 1H NMR (300 MHz, DMSO- d6) 5 8.72 (d, J = 1.9 Hz, 1H), 8.58 (d, J = 1.9 Hz, 1H), 7.14 (d, J = 2.5 Hz, 1H), 6.84 (d, J = 2.3 Hz, 1H), 6.64 (t, J = 8.0 339 Hz, 1H), 6.36 (d, J = 8.2 Hz, 1H), 6.22 (dd, J = 7.7, 1.0 Hz, 1H), 5.89 (s, 2H), 4.96 (m, 2H), 3.79 (m, 4H), 3.51 (m, 1H), 3.32 (m, 4H), 2.03 (m, 2H), 1.75 (m, 6H). 1H NMR (300 MHz, DMSO- d6) 5 8.73 (d, J = 1.9 Hz, 1H), 8.59 (d, J = 1.9 Hz, 1H), 7.25 (m, 1H), 7.14 (d, J = 2.4 Hz, 1H), 6.89 — 6.78 (m, 3H), 5.47 (d, J = 7.7 Hz, 1H), 4.94 (m, 1H), 4.29 (s, 2H), 3.79 (m, 4H), 3.51 (m, 1H), 3.06 (s, 3H), 2.09 (m, 2H), 1.81 (m, 6H).

WO 59690 Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (300 MHz, DMSO- d6) 6 8.72 (d, J = 1.9 Hz, 1H), 8.58 (d, J = 1.9 Hz, 1H), 8.17 (s, 2H), 7.15 (d, J = 2.4 Hz, 1H), 6.83 (d, J = 2.3 Hz, 1H), 6.06 (d, J = 7.8 Hz, 1H), 4.92 (m, 1H), 4.77 (s, 1H), 3.79 (m, 4H), 3.50 (m, 1H), 3.30 (m, 4H), 2.02 (m, 2H), 1.80 (m, 6H), 1.42 (s, 6H). 1H NMR (400 MHz, CDCI3) 6 8.86 (d, J = 0.9 Hz, 1H), 8.84 (s, 1H), 8.16 (s, 1H), 7.73 — 7.63 (m, 2H), 7.17 (d, J = 7.0 342 Hz, 1H), 5.24 (d, J = 7.8 Hz, 1H), 5.03 (s, 2H), 4.83 (s, 2H), 4.79 (s, 1H), 4.12 — 3.99 (m, 1H), 2.26 — 2.14 (m, 2H), 2.01 — 1.84 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 2.0 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 8.00 (d, J = 1.3 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.5 Hz, 1H), 4.88 (d, J = 8.2 Hz, 1H), 4.77 (s, 343 1H), 4.63 (d, J = 9.0 Hz, 2H), 4.15 (s, 1H), 3.92 (t, J = 4.9 Hz, 4H), 3.39 - 3.26 (m, 4H), 2.91 (td, J = 8.6, 3.9 Hz, 1H), 2.72 - 2.55 (m, 2H), 2.50 - 2.10 (m, 7H), 1.91 (d, J = 5.5 Hz, 6H), 1.72 (d, J = 4.7 Hz, 1H .

WO 59690 1H NMR (300 MHz, DMSO- d6) 69.18 (d, J = 1.5 Hz, 1H), 8.98 (t, 1H), 8.87 (d, J = 2.5 Hz, 1H), 8.76 — 8.69 (m, 2H), 8.57 (d, J = 1.9 Hz, 1H), 7.12 345 44959 (d, J = 2.6 Hz, 1H), 6.82 (d, J = 2.3 Hz, 1H), 4.94 (m, 1H), 3.78 (m, 4H), 3.27 (m, 6H), 1.99 (m, 2H), 1.83 — 1.48 (m, 7H). 1H NMR (300 MHz, DMSO- d6) 6 8.71 (d, J = 1.9 Hz, 1H), 8.59 (d, J = 1.9 Hz, 1H), 7.85 (t, 1H), 7.12 (d, J = 2.5 Hz, 346 385.56 1H), 6.83 (d, J = 2.4 Hz, 1H), 4.93 (m, 1H), 3.78 (m, 4H), 3.31 (m, 3H), 2.95 (t, J = 6.0 Hz, 2H), 2.03 — 1.90 (m, 2H), 1.80 (s, 3H), 1.52 (m, 7H). 2014/024767 Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (300 MHz, DMSO- d6) 5 8.72 (d, J = 1.9 Hz, 1H), 8.59 (s, 1H), 7.60 (d, J = 2.3 Hz, 1H), 7.46 (s, 1H), 7.13 (s, 1H), 6.83 (s, 1H), 6.46 (s, 1H), .97 (m, 1H), 4.96 (m 1H), 3.87 — 3.70 (m, 7H), 3.30 (s, 4H), 2.95 (t, J = 5.7 Hz, 2H), 1.99 (m, 2H), 1.62 (t, J = 18.1 Hz, 7H). 1H NMR (300 MHz, DMSO- d6) 6 8.72 (d, J = 1.9 Hz, 1H), 8.60 (d, J = 1.9 Hz, 1H), 8.24 (d, J = 4.7 Hz, 1H), 7.22 (t, J = 6.0 Hz, 1H), 7.11 (d, J = 2.6 348 Hz, 1H), 6.82 (d, J = 2.3 Hz, 1H), 6.51 (t, J = 4.7 Hz, 1H), 4.93 (m, 1H), 3.78 (m, 4H), 3.31 m, 4H), 3.19 (t, J = 6.5 Hz, 2H), 1.97 (m, 2H), 1.55 (m, 7H). 1H NMR (300 MHz, DMSO- d6) 5 8.72 (d, J = 1.9 Hz, 1H), 8.57 (d, J = 1.9 Hz, 1H), 7.59 (d, J = 5.9 Hz, 1H), 7.14 (d, J = 2.5 Hz, 1H), 6.82 (d, J = 2.3 Hz, 1H), 6.44 (d, J = 7.7 Hz, 1H), 6.22 (dd, J = 5.8, 2.1 Hz, 1H), 5.80 — 5.74 (m, 1H), 5.19 — 5.11 (m, 1H), 4.92 (m, 1H), 3.79 (m, 4H), 3.32 (m, 4H), 2.01 (m, 2H), 1.75 (m, 6H), 1.21 (d, J = 6.1 Hz, 6H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 4.79 (s, 1H), 4.24 - 3.76 (m, 5H), 3.50 - 3.20 (m, 4H), 3.02 (d, J = 5.1 Hz, 3H), 2.20 (d, J = 12.8 Hz, 350 464.42 2H), 2.09 - 1.75 (m, 6H), 5.29 - 5.19 (m, 1H), 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.49 (d, J = 4.8 Hz, 1H), 7.77 (s, 1H), 7.32 (d, J = 4.9 Hz, 1H), 7.02 - 6.86 (m, 2H). 1H NMR (300 MHz, form-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 2.0 Hz, 1H), 8.38 (d, J = 4.9 Hz, 1H), 6.93 (dd, J = 14.5, 2.4 351 478.38 Hz, 2H), 6.68 (d, J = 4.9 Hz, 1H), 5.28 (s, 1H),4.79(s,1H), 4.22 - 3.86 (m, 5H), 3.34 (t, J = 4.8 Hz, 4H), 3.17 - 2.97 (m, 6H), 2.20 (s, 2H), 1.91 (d, J = .1 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.91 - 8.75 (m, 2H), 8.11 (d, J = 5.9 Hz, 1H), 7.68 (d, J = 1.8 Hz, 1H), 6.37 (tt, J = 3.0, 1.5 Hz, 1H), 6.16 (d, J = 6.0 Hz, 1H), 4.99 (s, 1H), 4.88 (d, J = 6.0 Hz, 1H), 4.43 (q, J = 2.8 Hz, 2H), 4.02 (t, J = 5.4 Hz, 2H), 3.85 (s, 1H), 2.77 - 2.64 (m, 2H), 2.51 (s, 3H), 2.23 (d, J = 13.2 Hz, 2H), 2.03 - 1.82 (m, 6H).

WO 59690 Compound ESMS H NMR Compound Structure No. M+H 1H NMR (300 MHz, Chloroform-d) 6 8.67 (d, J = 1.9 Hz, 1H), 8.54 (d, J = 1.9 Hz, 1H), 8.11 (d, J = 6.0 Hz, 1H), 6.85 (s, 2H), 6.16 (d, J = 353 6.0 Hz, 1H), 5.00 (s, 1H), 4.85 (d, J = 6.5 Hz, 3H), 3.93 - 3.57 (m, 5H), 3.35 (q, J = 7.1 Hz, 1H), 2.62 (d, J = 8.0 Hz, 1H), 2.50 (s, 3H), 2.24 (d, J = 8.9 Hz, 2H), 2.01 - 1.81 (m, 6H). 1H NMR (300 MHz, DMSO- d6) 5 8.73 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 3.1 Hz, 1H), 8.58 (d, J = 2.0 Hz, 1H), 8.47 (d, J = 6.2 Hz, 1H), 7.15 (d, J = 2.4 354 Hz, 1H), 6.99 (d, J = 7.8 Hz, 1H), 6.83 (d, J = 2.3 Hz, 1H), 6.65 (m, 1H), 4.94 (m, 1H), 3.79 (m, 4H), 3.55 (m, 1H), 3.35 (m, 4H), 2.03 (m, 2H), 1.78 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.70 (d, J = 1.8 Hz, 1H), 8.61 o :1 (d, J = 1.8 Hz, 1H), 8.17 (s, M. 1H), 6.93 (d, J = 2.2 Hz, 1H), 6.71 (d, J = 2.2 Hz, 1H), 5.36 (d, J = 7.8 Hz, 1H), 5.04 (s, 355 421 .23 2H), 4.85 (s, 2H), 4.74 — 4.61 (m, 1H), 4.40 — 4.28 (m, 1H), 4.02 — 3.82 (m, 4H), 3.43 — 3.27 (m, 4H), 3.26 — 3.13 (m, 2H), 2.35 (dd, J = 19.4, 9.4 Hz, 2H). 2014/024767 Compound ESMS C°mp°”“d St“‘6 ”ret 1H NMR (400 MHz, CDCI3) 5 8.72 (s, 1H), 8.62 (d, J = 1.5 Hz, 1H), 8.50 (s, 1H), 7.74 (d, J = 1.9 Hz, 1H), 6.95 (d, J = 2.0 Hz, 1H), 6.86 (d, J = 1.9 Hz, 1H), 6.73 (d, J = 2.1 Hz, 1H), 5.44 (d, J = 7.5 Hz, 1H), 4.82 — 4.72 (m, 1H), 4.72 — 4.61 (m, 1H), 4.00 — 3.86 (m, 4H), 3.40 — 3.32 (m, 4H), 3.32 — 3.22 (m, 2H), 2.53 — 2.40 (m, 2H). 1H NMR (400 MHz, CDCI3) 5 8.71 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 8.12 (d, J = 5.9 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.70 (d, J = 2.4 Hz, 1H), 6.13 (d, J = 5.9 Hz, 1H), .06 (s, 1H), 4.72 (p, J = 6.9 Hz, 1H), 4.18 (s, 1H), 3.98 — 3.85 (m, 4H), 3.40 — 3.27 (m, 4H), 3.27 — 3.13 (m, 2H), 2.50 (s, 3H), 2.36 (ddd, J = 12.7, .0, 2.9 Hz, 2H). 1H NMR (300 MHz, DMSO- d6) 6 8.72 (d, J = 1.9 Hz, 1H), 8.57 (d, J = 1.9 Hz, 1H), 8.22 (m, 1H), 8.00 (d, J = 2.7 Hz, 1H), 7.73 (d, J = 8.6 Hz, 1H), 7.15 (d, J = 2.3 Hz, 1H), 7.02 358 (dd, J = 8.7, 2.8 Hz, 1H), 6.83 (d, J = 2.4 Hz, 1H), 6.50 (d, J = 7.6 Hz, 1H), 4.93 (m, 1H), 3.79 (m, 4H), 3.52 (m, 1H), 3.34 (m, 4H), 2.76 (d, J = 4.9 Hz, 3H), 2.04 (m, 2H), 1.79 (m, 6H).

Compound ESMS C d St t 1H NMR (300 MHz, form-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 7.99 (d, J = 1.3 Hz, 1H), 6.92 (dd, J = 16.0, 2.5 Hz, 2H), 5.12 (d, J = 7.5 Hz, 1H), 4.76 (d, J = 5.4 Hz, 1H), 4.69 - 4.54 (m, 1H), 4.15 (s, 537.71 1H), 4.01 - 3.82 (m, 4H), 3.72 (ddd, J = 13.2, 7.6, 2.9 Hz, 1H), 3.44 - 3.21 (m, 5H), 3.21 - 2.99 (m, 1H), 2.46 (dq, J = 7.9, 3.9 Hz, 1H), 2.34 (s, 3H), 2.22 (t, J = 8.8 Hz, 3H), 1.86 (dd, J = 10.0, 4.8 Hz, 7H), 1.79- 1.51 m, 2H. 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 7.16 (d, J = 1.2 Hz, 1H), 6.93 (dd, J = 17.1, 2.5 464.58 Hz, 2H), 5.38-5.21 (m,1H), 4.90 - 4.77 (m, 1H), 3.91 (dd, J = 6.0, 3.7 Hz, 5H), 3.44 - 3.26 (m, 4H), 3.00 (d, J = 5.1 Hz, 3H), 2.23 (d, J = 11.4 Hz, 2H), 2.04 - 1.76 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz,1H),8.61 (d, J :19 Hz, 1H), 8.38 (d, J = 4.9 Hz, 1H), 7.00 - 6.85 (m, 2H), 6.68 478.57 (d, J = 4.9 Hz, 1H), 5.29 (d, J = 7.7 Hz, 1H), 4.79 (s, 1H), 4.04 (s, 1H), 3.92 (dd, J = 6.0, 3.8 Hz, 4H), 3.41 - 3.26 (m, 4H), 3.10 (s, 3H), 3.04 (s, 3H), 2.19 (d, J = 8.7 Hz, 2H). nd ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.63 (t, J = 1.6 Hz, 1H), 8.04 (s, 1H), 6.95 (d, J = 2.3 Hz, 1H), 6.90 (d, J = 2.7 Hz, 1H), 4.88 (d, J = 8.3 362 512.55 Hz, 1H), 4.80 (s, 1H), 4.48 (t, J = 5.9 Hz, 2H), 4.17 (s, 1H), 4.01 - 3.81 (m, 4H), 3.34 (t, J = 4.7 Hz, 4H), 2.73 (t, J = 5.9 Hz, 2H), 2.33 (d, J = 1.2 Hz, 8H), 2.07 - 1.73 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.60 (d, J :19 Hz, 1H), 6.92 (dd, J = 21.1, 2.5 Hz, 2H), 4.74 (s, 1H), 4.35 (d, J = 7.9 Hz, 1H), 4.12 (d, J 363 469.62 = 8.0 Hz, 1H), 4.03 - 3.67 (m, 5H), 3.63 - 3.50 (m, 1H), 3.47 - 3.20 (m, 4H), 2.77 (d, J = 11.3 Hz, 2H), 2.28 (s, 3H), 2.22 - 2.04 (m, 4H), 1.90 (dd, J = 38.6, 8.3 Hz, 8H), 1.45 (qd, J = 11.1, 3.8 Hz, 2H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.59 (d, J = 2.0 Hz, 1H), 6.92 (dd, J = 21.8, 2.5 Hz, 2H), 4.75 (s, 1H), 4.47 (dd, J = 28.7, 10.8 Hz, 2H), 364 497.61 4.19 (d, J = 7.7 Hz, 1H), 3.99 - 3.68 (m, 6H), 3.46 - 3.27 (m, 4H), 3.18 (t, J = 11.7 Hz,1H), 2.85 - 2.64 (m, 1H), 2.11 (s, 5H), 1.83 (d, J = 4.9 Hz, 6H), 1.41 - 1.17 (m, 5H). 2014/024767 Compound ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (300 MHz, Chloroform-d) 6 8.67 (dd, J = 21.6, 1.9 Hz, 2H), 8.01 (s, 1H), 6.94 (dd, J = 16.5, 2.5 Hz, 2H), 4.79 (s, 1H), 4.67 (s, 365 2H), 4.18 (s, 2H), 3.93 (t, J = 4.8 Hz, 4H), 3.41 - 3.27 (m, 6H), 2.20 (d, J = 9.9 Hz, 2H), 1.93 (d, J = 5.5 Hz, 6H), 0.63 - 0.50 (m, 2H), 0.29 (t, J = 5.0 Hz, 2H). 1H NMR (400 MHz, CDCI3) 5 8.90 (dd, J = 7.2, 1.8 Hz, 2H), 8.75 (dd, J = 4.5, 1.6 Hz, 2H), 8.10 (d, J = 6.0 Hz, 1H), 7.97 (d, J =1.7 Hz, 1H), 7.62 (dd, J 367 = 4.5, 1.6 Hz, 2H), 7.38 (d, J = 1.7 Hz, 1H), 6.15 (d, J = 6.0 Hz, 1H), 4.98 (s, 1H), 4.93 (s, 1H), 3.86 (s, 1H), 2.49 (s, 3H), 2.34 — 2.18 (m, 2H), 1.96 (dd, J = 20.7, 8.9 Hz, 6H). nd ESMS H NMR C d St t 1H NMR (300 MHz, DMSO- d6) 5 8.73 (d, J = 2.0 Hz, 1H), 8.60 (d, J = 2.0 Hz, 1H), 7.96 (s, 2H), 7.15 (d, J = 2.5 Hz, 1H), 6.85 (d, J = 2.4 Hz, 1H), 368 343.48 4.97 (m, 1H), 3.79 (t, J = 4.9 Hz, 4H), 3.35 (t, J = 4.9 Hz, 4H), 2.72 (t, J = 6.2 Hz, 2H), 2.65 (m, 1H), 2.01 (m, 2H), 1.77 — 1.48 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 7.71 (s, 1H), 6.94 (dd, J = 14.6, 2.5 Hz, 2H), 369 436.5 5.09 (d, J = 7.7 Hz, 1H), 4.80 (d, J = 5.4 Hz, 1H), 4.29 (s, 2H), 4.01 - 3.84 (m, 4H), 3.45 - 3.28 (m, 4H), 2.49 (s, 3H), 2.21 (q, J = 6.1 Hz, 2H), 1.95 (dt, J = 10.0, 4.1 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (t, J = 1.9 Hz, 1H), 8.64 (dd, J = 3.9, 2.0 Hz, 1H), 8.11 (s, 1H), 7.01 - 6.90 (m, 2H), 4.75 (d, J = 370 448.25 20.3 Hz, 2H), 4.23 (s, 2H), 3.93 (t, J = 4.8 Hz, 4H), 3.68 (t, J = 8.7 Hz, 2H), 3.42 - 3.29 (m, 4H), 2.90 (t, J = 8.7 Hz, 2H), 2.34 - 2.12 (m, 2H), 2.11 - 1.83 (m, 6H).

Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (300 MHz, form-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 7.79 (d, J = 5.6 Hz, 1H), 7.03 - 6.89 (m, 2H), 6.05 (d, J = 5.6 Hz, 1H), 4.77 (d, J 371 447.5 = 5.9 Hz, 1H), 4.21 (s,1H), 3.93 (dd, J = 6.0, 3.7 Hz, 4H), 3.68 (t, J = 8.7 Hz, 2H), 3.36 (dd, J = 5.8, 4.0 Hz, 4H), 2.85 (t, J = 8.7 Hz, 2H), 2.20 (q, J = 12.1, 9.5 Hz, 2H), 1.94 (t, J = .8 Hz, 6H). 372 446.44 1H NMR (400 MHz, CDCI3) 6 8.71 (d, J = 1.8 Hz, 1H), 8.63 (d, J = 1.8 Hz, 1H), 7.70 (d, J = 5.0 Hz, 2H), 6.97 (d, J = 1.6 Hz, 1H), 6.92 (d, J = 2.1 Hz, 373 421.51 1H), 4.81 (s, 1H), 4.65 (s, 1H), 3.99 — 3.85 (m, 5H), 3.40 — 3.30 (m, 4H), 2.37 (s, 3H), 2.28 — 2.16 (m, 2H), 2.01 — 1.82 (m, 6H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, form-d) 6 8.81 - 8.67 (m, 2H), 8.01 (d, J = 6.0 Hz, 1H), 7.46 (dd, J = 1.7, 0.7 Hz, 1H), 6.98 (d, J = 1.7 Hz, 1H), 6.06 (d, J = 6.0 Hz, 1H), 4.80 (d, J = 38.5 Hz, 2H), 4.13 - 3.97 (m, 3H), 3.51 (td, J = 11.3, 3.5 Hz, 2H), 2.99 - 2.80 (m, 1H), 2.41 (s, 3H), 2.21 - 2.03 (m, 2H), 1.94 - 1.70 (m, 7H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.07 (s, 1H), 6.93 (dd, J = 17.0, 2.5 Hz, 2H), 376 4.98 - 4.71 (m, 2H), 4.17 (s, 1H), 4.00 (s, 3H), 3.92 (dd, J = 5.8, 3.9 Hz, 4H), 3.42 - 3.26 (m, 4H), 2.22 (d, J = 9.5 Hz, 2H), 1.93 (dd, J = 6.1, 2.4 Hz, 6H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, form-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 7.95 (d, J = 1.2 Hz, 1H), 6.92 (dd, J = 16.9, 2.5 Hz, 2H), 4.98 (s, 1H), 4.81 - 377 512.36 4.66 (m, 2H), 4.16 (s, 1H), 3.97 - 3.87 (m, 4H), 3.46 (d, J = 6.1 Hz, 2H), 3.39 - 3.29 (m, 4H), 2.19 (d, J = 12.5 Hz, 2H), 1.91 (d, J = 5.4 Hz, 6H), 1.26 (s, 6H), 0.94 - 0.83 (m, 1H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 7.99 (d, J = 1.3 Hz, 1H), 6.92 (dd, J = 17.1, 2.5 Hz, 2H), 4.77 (s, 1H), 4.66 (d, 378 J = 8.5 Hz, 1H), 4.41 (d, J = 7.7 Hz, 1H), 4.23 - 4.10 (m, 2H), 4.05 - 3.87 (m, 6H), 3.54 (td, J = 11.7, 2.1 Hz, 2H), 3.39 - 3.29 (m, 4H), 2.19 (d, J = 11.3 Hz, 2H), 2.08 - 1.85 (m, 8H), 1.64 - 1.44 (m, 2H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.00 (d, J =1.3 Hz, 1H), 6.95 (d, J = 2.5 Hz, 1H), 379 6.89 (d, J = 2.5 Hz, 1H), 4.87 - 4.56 (m, 4H), 4.16 (s, 1H), 4.04 - 3.65 (m, 8H), 3.46 - 3.26 (m, 4H), 2.43 - 2.26 (m, 1H), 2.20 (q, J = 6.6, 5.9 Hz, 2H), 1.90 (t, J = 5.5 Hz, 6H). nd ESMS C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 2.0 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.00 - 7.91 (m, 1H), 6.92 (dd, J = 17.2, 2.5 Hz, 2H), 4.87 - 4.64 (m, 2H), 4.59 (d, J = 5.7 Hz, 1H), 4.16 (ddt, 380 J = 9.7, 6.8, 3.7 Hz, 2H), 4.01 - 3.85 (m, 4H), 3.75 (d, J = 11.2 Hz, 1H), 3.58 (dd, J = .9, 7.0 Hz, 1H), 3.48 - 3.23 (m, 4H), 2.36 - 2.07 (m, 2H), 1.91 (d, J = 5.5 Hz, 6H), 1.28 (d, J = 6.8 Hz, 3H), 0.97 - 0.78 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 7.98 (d, J = 7.3 Hz, 1H), 6.92 (dd, J = 16.7, 2.5 Hz, 2H), 4.87 (d, J = 8.6 Hz, 1H), 4.77 (s, 2H), 4.61 (s, 2H), 4.15 (s, 1H), 3.91 (dd, J = 5.9, 3.8 Hz, 4H), 3.46 - 3.29 (m, 4H), 2.99 - 2.77 (m, 2H), 2.74 - 2.54 (m, 2H), 2.46 - 2.10 (m, 6H), 1.91 (d, J = 5.5 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.00 (s, 1H), 6.92 (dd, J = 16.5, 2.5 Hz, 2H), 4.92 (s, 1H), 4.77 (s, 1H), 382 4.64 (d, J = 8.5 Hz, 1H), 4.16 (s, 1H), 4.03 - 3.82 (m, 4H), 3.65 (q, J = 5.8, 5.4 Hz, 2H), 3.56 (ddd, J = 5.6, 4.7, 1.0 Hz, 2H), 3.48 - 3.21 (m, 7H), 2.19 (d, J = 10.1 Hz,2H),1.91 (d, J = 5.4 Hz, 6H). nd ESMS H NMR 1H NMR (300 MHz, Chloroform-d) 6 8.69 (s, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.55 (d, J :19 Hz, 1H), 6.93 - 6.71 (m, 3H), 6.22 (dd, J = 3.6, 2.0 383 Hz, 1H), 5.01 (d, J = 8.1 Hz, 1H), 4.71 (s, 1H), 4.34 (s, 1H), 3.92 - 3.78 (m, 7H), 3.26 (dd, J = 5.9, 3.9 Hz, 4H), 2.15 (d, J = 10.8 Hz, 2H), 1.98 - 1.78 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.72 (d, J 2.0 Hz, 1H), 8.65 (d, J =1. Hz, 1H), 8.39 (s, 1H), 7.01 ILOII 6.90 (m, 3H), 6.35 (d, J = 3.5 Hz, 1H), 5.05 (t, J = 8.6 Hz, 1H), 4.83 (d, J = 5.6 Hz, 1H), 4.41 (s, 1H), 4.01 - 3.87 (m, 4H), 3.82 (d, J =1.1 Hz, 3H), 3.44 - 3.30 (m, 4H), 2.27 (d, J = 8.9 Hz, 2H), 2.12 - 1.86 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.72 (d, J = 1.9 Hz, 1H), 8.65 (d, J :19 Hz, 1H), 8.03 (d, J = 5.6 Hz, 1H), 7.11 (d, J = 3.6 Hz,1H), 7.03 - 6.91 (m, 2H), 6.41 (d, J = 3.6 Hz, 1H), 6.28 (d, J = 5.7 Hz, 1H), 4.83 (s, 1H), 4.56 (d, J = 8.0 Hz,1H),4.01 - 3.88 (m, 4H), 3.78 (s, 1H), 3.44 - 3.30 (m, 4H), 2.28 (d, J = 10.0 Hz, 2H), 2.11 - 1.85 (m, 6H).

WO 59690 Compound ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (400 MHz, CDCI3) 5 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 7.49 (s, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 5.25 386 480.41 (s, 1H), 4.72 (s, 1H), 4.18 (s, 1H), 3.96 — 3.87 (m, 4H), 3.77 (s, 3H), 3.39 — 3.30 (m, 4H), 3.10 (s, 6H), 2.21 — 2.12 (m, 2H), 2.02 — 1.85 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 7.49 (s, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 5.25 387 466.4 (s, 1H), 4.72 (s, 1H), 4.18 (s, 1H), 3.96 — 3.87 (m, 4H), 3.77 (s, 3H), 3.39 — 3.30 (m, 4H), 3.10 (s, 6H), 2.21 — 2.12 (m, 2H), 2.02 — 1.85 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 8.04 (s, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 5.15 388 480.41 (d, J = 8.4 Hz, 1H), 4.75 (s, 1H), 4.14 (s, 1H), 3.97 — 3.83 (m, 4H), 3.59 (s, 3H), 3.38 — 3.28 (m, 4H), 3.09 (s, 6H), 2.25 — 2.13 (m, 2H), 2.00 — 1.83 (m, 6H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz,1H),8.61 (d, J :19 Hz, 1H), 8.50 (d, J =1.1 Hz, 1H), 6.93 (dd, J = 16.5, 2.5 Hz, 2H), 6.49 (s, 1H), 4.90 (s, 389 504.48 1H), 4.80 (s, 1H), 4.08 - 3.87 (m, 5H), 3.44 - 3.29 (m, 6H), 2.45 (t, J = 5.3 Hz, 4H), 2.26 - 2.14 (m, 2H), 1.90 (t, J = 6.5 Hz, 6H), 1.63 (d, J = 5.7 Hz, 4H), 1.53 - 1.43 (m, 2H). 1H NMR (300 MHz, form-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.50 (d, J =1.1 Hz, 1H), 6.93 (dd, J = 16.5, 2.5 390 464.62 Hz, 2H), 6.44 (d, J =1.1 Hz, 1H), 4.93 (s, 1H), 4.80 (s, 1H), 3.97 - 3.87 (m, 4H), 3.47 - 3.29 (m, 6H), 2.31 (s, 6H), 2.21 (d, J = 9.1 Hz, 2H), 1.89 (t, J = 6.9 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.68 (d, J = 1.9 Hz, 1H), 8.58 (d, J :19 Hz, 1H), 6.94 (d, J = 2.5 Hz, 1H), 6.86 (d, J = 2.5 Hz, 1H), 4.81 - 4.61 (m, 3H), 4.47 (td, J 391 500.63 = 8.7, 5.2 Hz, 1H), 3.98 - 3.88 (m, 4H), 3.85 - 3.66 (m, 4H), 3.40 - 3.25 (m, 4H), 2.24 - 2.07 (m, 2H), 1.93 - 1.74 (m, 6H), 1.71-1.64 (m, 1H). 1.58 - 1.39 (m, 2H), 0.93 (t, J = 6.3 Hz, 6H). 2014/024767 Compound ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (300 MHz, DMSO- d6) 6 8.71 (d, J = 1.9 Hz, 1H), 8.58 (d, J = 1.9 Hz, 1H), 7.10 (d, J = 2.5 Hz, 1H), 6.82 (d, J 392 443.61 = 2.6 Hz, 2H), 4.92 (m, 1H), 3.78 (m, 4H), 3.30 (m, 5H), 2.84 (t, J = 6.0 Hz, 2H), 1.96 — 1.33 (m, 18H). 1H NMR (300 MHz, DMSO- d6) 6 8.73 (d, J = 1.9 Hz, 1H), 8.58 (d, J = 1.9 Hz, 1H), 8.10 (d, J = 2.7 Hz, 1H), 7.97 (d, J = 8.9 Hz, 1H), 7.38 (dd, J = 393 450.58 9.0, 2.7 Hz, 1H), 7.16 (d, J = 2.4 Hz, 1H), 6.84 (d, J = 2.3 Hz, 1H), 4.96 (m, 1H), 3.79 (m, 4H), 3.66 (m, 1H), 3.3 (m, 4H), 2.14 - 1.95 (m, 2H), 1.81 (m, 5H). 1H NMR (300 MHz, DMSO- d6) 6 8.72 (d, J = 1.9 Hz, 1H), 8.58 (d, J = 1.9 Hz, 1H), 7.54 (d, J = 8.6 Hz, 1H), 7.14 (d, J = 2.4 Hz, 1H), 6.83 (d, J = 2.3 394 Hz, 1H), 6.48 (d, J = 7.7 Hz, 1H), 6.30 — 6.18 (m, 2H), 4.92 (m, 1H), 3.79 (m, 4H), 3.74 (s, 3H), 3.66 (s, 3H), 3.55 (m, 1H), 3.34 (m, 4H), 2.03 (m, 2H), 1.78 (m, 6H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, form-d) 6 8.61 (d, J = 1.9 Hz, 1H), 8.53 (d, J = 2.0 Hz, 1H), 7.13 (d, J = 5.3 Hz, 1H), 6.84 (dd, J = 20.0, 2.4 395 441 .2 Hz, 2H), 5.40 (d, J = 8.2 Hz, 1H), 4.72 (s, 1H), 4.31 (d, J = 7.0 Hz, 1H), 3.83 (dd, J = 5.8, 3.8 Hz, 4H), 3.26 (t, J = 4.9 Hz, 4H), 2.14 (d, J = 12.3 Hz, 2H), 1.95 - 1.68 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.61 (d, J = 1.9 Hz, 1H), 8.54 (d, J :19 Hz, 1H), 7.72 (d, J = 2.9 Hz, 1H), 6.87 (d, J = 2.5 Hz, 1H), 396 455.2 6.81 (d, J = 2.5 Hz, 1H), 5.03 (d, J = 7.8 Hz, 1H), 4.71 (s, 1H), 4.16 (s, 2H), 3.83 (q, J = 3.9, 3.1 Hz, 7H), 3.32 - 3.21 (m, 4H), 2.13 (d, J = 11.2 Hz, 2H), 1.83 (t, J = 6.5 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 7.89 (d, J = 5.8 Hz, 1H), 7.02 - 6.88 (m, 2H), 5.79 (d, J = 5.7 Hz, 1H), 4.80 (s, 1H), 4.61 (s, 2H), 4.08 - 3.88 (m, 5H), 3.35 (dd, J = 5.6, 4.1 Hz, 4H), 2.27 - 2.09 (m, 2H), 1.91 (d, J = 5.0 Hz, 6H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, form-d) 6 8.62 (d, J = 1.9 Hz, 1H), 8.54 (d, J :19 Hz, 1H), 8.38 (s, 1H), 6.94 - 6.74 (m, 2H), 4.69 (s, 1H), 398 4.34 (s, 1H), 4.25 (s, 1H), 3.84 (dd, J = 5.9, 3.8 Hz, 4H), 3.30 - 3.14 (m, 6H), 2.79 (d, J = 5.7 Hz, 2H), 2.71 (d, J = 5.6 Hz, 2H), 2.49 (s, 3H), 2.13 (m, 2H), 1.85 (d, J = 5.5 Hz, 6H). 1H NMR (300 MHz, CDCI3) 6 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.08 (d, J = 6.3 Hz, 1H), 6.96 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.4 Hz, 399 1H), 6.23 (d, J = 6.3 Hz, 1H), 4.87 (s, 1H), 4.69 (s, 1H), 4.00 — 3.83 (m, 4H), 3.45 — 3.24 (m, 4H), 2.98 (s, 3H), 2.50 (s, 3H), 2.45 — 2.30 (m, 2H), 1.92 — 1.64 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 6.94 (dd, J = 19.8, 400 2.4 Hz, 2H), 5.09 (s, 1H), 4.81 (s, 1H), 4.01 - 3.88 (m, 4H), 3.42 - 3.29 (m, 4H), 2.91 (d, J = 4.8 Hz, 3H), 2.18 (m, 2H), 1.90 (s, 6H).

WO 59690 Compound ESMS H NMR Compound Structure 1H NMR (300 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 7.51 (s, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 5.56 401 471.32 (d, J = 8.0 Hz, 1H), 4.75 (s, 1H), 4.25 (s, 1H), 3.96 — 3.89 (m, 4H), 3.88 (s, 3H), 3.47 — 3.23 (m, 4H), 2.29 — 2.06 (m, 2H), 2.06 — 1.78 (m, 6H). 1H NMR (300 MHz, CDCI3) 5 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.14 (s, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.5 Hz, 1H), 5.52 402 471.36 (d, J = 8.6 Hz, 1H), 4.79 (s, 1H), 4.18 (s, 1H), 3.96 — 3.89 (m, 4H), 3.89 (s, 3H), 3.41 — 3.27 (m, 4H), 2.31 — 2.14 (m, 2H), 2.03 — 1.83 (m, 6H). 1H NMR (300 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.5 Hz, 1H), 4.77 (s, 1H), 4.68 (d, 403 463.4 J = 8.4 Hz, 1H), 4.58 (t, J = 9.1 Hz, 2H), 4.25 (s, 1H), 3.98 — 3.84 (m, 4H), 3.40 — 3.27 (m, 4H), 3.19 (t, J = 9.0 Hz, 2H), 2.49 (s, 3H), 2.25 — 2.10 (m, 2H), 2.00 — 1.82 (m, 6H). nd ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (300 MHz, DMSO- d6) 5 8.72 (d, J = 1.9 Hz, 1H), 8.57 (d, J = 1.9 Hz, 1H), 7.69 (s, 1H), 7.15 (d, J = 2.5 Hz, 404 480.56 1H), 7.01 (s, 1H), 6.84 (d, J = 2.3 Hz, 1H), 4.94 (m, 1H), 3.75 (m, 8H), 3.34 (m, 4H), 2.05 (m, 2H), 1.86 — 1.70 (m, 6H). 1H NMR (300 MHz, DMSO- d6) 5 8.72 (d, J = 1.9 Hz, 1H), 8.57 (d, J = 1.9 Hz, 1H), 8.01 (m, 1H), 7.14 (s, 1H), 7.01 — 6.90 (m, 1H), 6.82 (m, 2H), 405 480.56 6.71 (m, 1H), 5.70 (d, J = 7.9 Hz, 1H), 4.91 (m, 1H), 3.79 (m, 4H), 3.34 (m, 5H), 2.74 (d, J = 4.6 Hz, 3H), 2.02 (m, 2H), 1.76 (m, 6H). 1H NMR (300 MHz, DMSO- d6) 5 8.72 (d, J = 1.9 Hz, 1H), 8.58 (d, J = 1.9 Hz, 1H), 8.27 (d, J = 5.2 Hz, 1H), 7.46 (dd, J = 8.4, 7.1 Hz, 1H), 7.15 (d, J = 2.4 Hz, 1H), 7.10 (dd, J = 7.1, 0.9 Hz, 1H), 6.83 (d, J = 2.3 406 463.68 Hz, 1H), 6.75 (d, J = 7.8 Hz, 1H), 6.68 (dd, J = 8.4, 0.9 Hz, 1H), 4.91 (m, 1H), 4.14 (m, 1H), 3.80 (m, 4H), 3.35 (m, 4H), 2.82 (d, J = 4.9 Hz, 3H), 2.03 (m, 2H), 1.93 — 1.73 (m, 6H . nd ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) rotomers, 6 9.07 (m, 1H), 8.89 (m, 1H), 8.75 (m, 1H), 7.47 (m, 1H), 407 536.49 6.96 (s, 1H), 4.95 (m, 1H), 3.97 (m, 4H), 3.82 (m, 4H), 3.38 (s, 3H), 2.24 (m, 8H), 1.60 (s, 9H). 1H NMR (300 MHz, DMSO- d6) 6 8.72 (d, J :19 Hz, 1H), 8.57 (d, J :19 Hz, 1H), 7.13 (d, J = 2.4 Hz, 1H), 6.94 (t, J = 8.0 Hz, 1H), 6.83 (d, J = 2.3 408 435.6 Hz, 1H), 6.26 — 6.14 (m, 2H), 6.10 — 6.03 (m, 1H), 5.57 (d, J = 7.8 Hz, 1H), 4.90 (m, 1H), 3.79 (m, 4H), 3.66 (s, 3H), 3.33 (m, 4H), 2.03 (m, 2H), 1.77 (m, 6H). 1H NMR (300 MHz, CDCI3) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J =1.9 Hz, 1H), 8.47 (s, 1H), 8.18 (s, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.4 409 Hz, 1H), 5.47 (d, J = 7.6 Hz, 1H), 4.80 (s, 1H), 4.31 — 4.19 (m, 1H), 4.02 — 3.79 (m, 4H), 3.48 — 3.24 (m, 4H), 2.32 — 2.17 (m, 2H), 2.09 — 1.79 (m, 6H). nd ESMS C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.68 (d, J = 2.0 Hz, 1H), 8.59 (d, J :19 Hz, 1H), 6.94 (d, J = 2.5 Hz, 1H), 6.87 (d, J = 2.5 Hz, 1H), 4.73 (d, J = 5.5 Hz, 1H), 4.49 - 4.19 (m, 2H), 4.03 - 3.87 (m, 410 4H), 3.81 (q, J = 6.6 Hz, 1H), 3.44 - 3.25 (m, 4H), 2.99 (t, J = 6.3 Hz, 2H), 2.13 (q, J = 7.5, .0 Hz, 2H), 1.99 - 1.57 (m, 11H), 1.42 (dqd, J = 10.0, 7.1, 6.7, 3.4 Hz, 1H), 1.20 (tt, J = 17.8, 10.5 Hz, 3H), 0.91 (q, J = 12.1 Hz, 2H 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 6.94 (d, J = 2.5 Hz, 1H), 6.87 (d, J = 2.5 Hz, 1H), 4.70 (d, J = 2.6 Hz, 1H), 4.41 (d, J = 7.7 Hz, 1H), 3.97 - 3.81 (m, 4H), 3.41 - 3.25 (m, 4H), 2.91 (s, 6H), 2.15 (d, J = 9.2 Hz, 2H), 1.98 - 1.71 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.60 (d, J :19 Hz, 1H), 6.90 (dd, J = 21.6, 2.5 Hz, 2H), 4.72 (s, 1H), 4.48 (d, J = 7.9 Hz, 1H), 4.04 - 3.82 (m, 4H), 3.78 - 3.62 (m, 4H), 3.34 (dt, J = 5.0, 3.2 Hz, 8H), 2.15 (s, 2H), 1.84 (d, J = 4.8 Hz, 6H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 ,8.61 (d, J = 2.0 Hz, 1H), 6.94 (d, J = 2.5 Hz, 1H), 6.87 (d, J = 2.5 Hz, 1H), 413 4.71 (d, J = 5.4 Hz, 1H), 4.37 (d, J = 7.9 Hz, 1H), 3.99 - 3.81 (m, 4H), 3.44 - 3.09 (m, 8H), 2.24 - 2.06 (m, 2H), 1.94 - 1.73 (m, 6H), 1.15 (t, J = 7.1 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.60 (d, J :19 Hz, 1H), 6.94 (d, J = 2.5 Hz, 1H), 6.87 (d, J = 2.5 Hz, 1H), 414 4.72 (d, J = 5.6 Hz, 1H), 4.50 (d, J = 7.6 Hz, 1H), 4.02 - 3.80 (m, 4H), 3.49 - 3.18 (m, 8H), 2.41 (t, J = 5.1 Hz, 4H), 2.32 (s, 3H), 2.22 - 2.05 (m, 2H), 1.95 - 1.75 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 6.94 (d, J = 2.5 Hz, 1H), 6.87 (d, J = 2.5 Hz, 1H), 4.70 (s, 1H), 4.24 (d, J = 7.9 Hz, 1H), 4.02 - 3.82 (m, 5H), 3.44 - 3.23 (m, 8H), 2.61 (s, 1H), 2.26 - 2.06 (m, 2H), 1.99 - 1.73 (m, 9H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, form-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.87 (d, J = 2.5 Hz, 1H), 416 4.70 (d, J = 4.4 Hz, 1H), 4.48 (d, J = 7.6 Hz, 1H), 4.03 - 3.80 (m, 5H), 3.49 (d, J = 4.2 Hz, 2H), 3.45 - 3.17 (m, 8H), 2.23 - 2.04 (m, 2H), 2.02 - 1.73 (m, 6H), 1.56 - 1.49 (m, 4H). 1H NMR (300 MHz, Chloroform-d) 6 8.81 - 8.55 (m, 3H), 6.94 (dd, J = 17.2, 2.5 Hz, 2H), 6.65 (d, J =1.1 417 Hz, 1H), 4.84 (td, J = 5.1, 2.4 Hz, 1H), 4.01 - 3.86 (m, 4H), 3.42 - 3.29 (m, 4H), 2.35 - 2.11 (m, 2H), 2.05 - 1.82 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.49 (d, J = 4.9 Hz, 1H), 7.04 - 6.89 (m, 2H), 6.81 418 (d, J = 4.9 Hz, 1H), 5.54 (d, J = 7.9 Hz, 1H), 4.80 (d, J = 5.2 Hz, 1H), 4.17 - 3.98 (m, 1H), 3.98 - 3.87 (m, 4H), 3.42 - 3.31 (m, 4H), 2.33 - 2.12 (m, 2H), 2.06 - 1.72 (m, 6H).

Compound ESMS H NMR “d St“‘6 ”ret 1H NMR (300 MHz, Chloroform-d) rotomers 6 8.82 (d, J = 2.9 Hz, 1H), 8.74 (m, 1H), 8.00 (m, 1H), 7.55 - 7.47 (m, 1H), 7.25 (m, 1H), 7.14 (m, 1H), 7.05 (m, 1H), 3.97 (m, 5H), 3.47 (m, 5H), 2.30 (s, 2H), 2.0 (m, 6H).. 1H NMR (300 MHz, DMSO- d6) 5 8.73 (d, J :19 Hz, 1H), 8.58 (d, J = 2.0 Hz, 1H), 7.27 — 6.96 (m, 4H), 6.83 (d, J = 2.3 Hz, 1H), 4.92 (m, 1H), 3.85 — 3.74 (m, 4H), 3.45 (m, 1H), 3.34 (m, 4H), 2.05 (m, 2H), 1.76 (m, 6H). 1H NMR (300 MHz, DMSO- d6) 6 8.93 (d, J = 1.8 Hz, 1H), 8.80 (d, J = 1.8 Hz, 1H), 7.20 (s, 1H), 7.13 - 6.85 (m, 4H), 4.92 (m, 1H), 3.86 - 3.79 (m, 4H), 3.32 (m, 5H), 2.09 (m, 2H), 1.90 - 1.73 (m, 6H), 1.55 (s, 9H). nd ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.72 - 8.52 (m, 3H), 8.38 (s, 1H), 6.87 (dd, J = 15.7, 2.5 Hz, 2H), .50 (d, J = 7.9 Hz, 1H), 4.79 422 432.5 (p, J = 3.5 Hz, 1H), 4.20 (dp, J = 14.0, 5.2, 4.7 Hz, 1H), 3.90 - 3.76 (m, 4H), 3.32 - 3.22 (m, 4H), 2.29 - 2.07 (m, 2H), 1.99 - 1.71 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.74 (d, J = 1.9 Hz, 1H), 8.65 (s, 1H), 8.01 (s, 1H), 7.05 - 6.88 (m, 2H), 4.87 (s, 1H), 3.95 (d, J = 4.7 423 481 .3 Hz, 4H), 3.77 - 3.56 (m, 1H), 3.37 (dd, J = 5.8, 3.8 Hz, 4H), 3.11 (qd, J = 7.4, 4.2 Hz,1H), 2.28 (s, 2H), 1.98 (dd, J = 22.7, 9.4 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.62 (d, J = 1.9 Hz, 1H), 8.52 (d, J :19 Hz, 1H), 8.46 - 8.35 (m, 1H), 6.84 (dd, J = 16.8, 2.5 Hz, 424 437.3 2H), 6.28 - 6.20 (m, 1H), 5.08 (s, 1H), 4.72 (d, J = 5.2 Hz, 1H), 4.58 - 4.43 (m, 2H), 3.93 - 3.77 (m, 4H), 3.34 - 3.19 (m, 4H), 2.14 (dd, J = 9.6, 5.4 Hz, 2H), 1.93 - 1.73 (m, 6H). nd ESMS H NMR 1H NMR (300 MHz, Chloroform-d) 6 8.68 (d, J = 2.0 Hz, 1H), 8.59 (d, J = 2.0 Hz, 1H), 6.93 (d, J = 2.5 Hz, 1H), 6.86 (d, J = 2.5 Hz, 1H), 425 4.72 (s, 1H), 4.20 (s, 1H), 4.11 (s, 1H), 3.98 - 3.85 (m, 4H), 3.78 (s, 1H), 3.40 - 3.24 (m, 4H), 2.14 (d, J = 9.2 Hz, 2H), 1.81 (t, J = 6.3 Hz, 6H), 1.33 (s, 9H). 1H NMR (300 MHz, Chloroform-d) 6 9.26 (m, 2H), 8.90 (m, 1H), 8.79 - 8.64 (m, 426 2H), 7.22 - 7.01 (m, 3H), 4.97 (m, 1H), 4.01 - 3.87 (m, 4H), 3.38 (m, 5H), 2.77 (s, 3H), 2.19 (m, 9H). 1H NMR (300 MHz, Chloroform-d) 6 8.94 - 8.63 (m, 2H), 8.07 (d, J = 2.8 Hz, 1H), 7.45 (d, J = 8.7 Hz, 1H), 7.14 - 6.87 (m, 3H), 4.84 (m, 1H), 3.99 - 3.87 (m, 4H), 3.62 - 3.48 (m, 1H), 3.35 (dt, J = 42.8, 4.8 Hz, 4H), 2.32 - 2.14 (m, 2H), 1.91 (d, J = 17.8 Hz, 6H). nd ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.81 - 8.64 (m, 2H), 8.20 (s, 2H), 7.08 (d, J = 2.4 Hz, 1H), 6.94 (d, J = 428 475.41 2.4 Hz, 1H), 4.90 - 4.82 (m, 1H), 4.42 (m, 1H), 3.98 - 3.88 (m, 4H), 3.57 (m, 1H), 3.45 - 3.26 (m, 4H), 2.33 - 2.18 (m, 2H), 2.04 - 1.82 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 2.0 Hz, 1H), 8.63 (d, J = 2.0 Hz, 1H), 8.42 (m, 1H), 8.16 - 8.08 (m, 1H), 7.20 (s, 1H), 429 7.04 - 6.98 (m, 1H), 6.94 (d, J = 2.4 Hz, 1H), 4.84 (m, 1H), 4.01 - 3.87 (m, 4H), 3.54 (m, 1H), 3.42 - 3.26 (m, 4H), 2.33 - 2.19 (m, 2H), 2.08 - 1.80 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.15 (s, 2H), 7.03 - 6.85 (m, 2H), 5.09 (d, J = 8.1 430 Hz, 1H), 4.78 (s, 1H), 3.92 (dd, J = 5.9, 3.7 Hz, 5H), 3.40 - 3.24 (m, 4H), 2.71 - 2.33 (m, 8H), 2.30 (s, 3H), 2.20 (s, 2H), 1.91 (d, J = 5.0 Hz, 6H), 1.26 (d, J = 3.1 Hz, 4H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.15 (s, 2H), 6.99 - 6.86 (m, 2H), 5.10 (d, J = 8.1 431 478.47 Hz, 1H), 4.79 (d, J = 5.9 Hz, 1H), 4.09 - 3.85 (m, 5H), 3.41 - 3.25 (m, 4H), 2.68 - 2.51 (m, 2H), 2.52 - 2.37 (m, 2H), 2.28 (s, 6H), 2.19 (q, J = 6.2, 5.8 Hz, 2H), 2.02 - 1.81 (m, 6H). 1H NMR (300 MHz, form-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.16 (s, 2H), 6.98 - 6.86 (m, 2H), 5.10 (d, J = 8.1 432 504.44 Hz, 1H), 4.78 (s, 1H), 4.08 - 3.83 (m, 5H), 3.39 - 3.27 (m, 4H), 2.60 (d, J = 16.9 Hz, 8H), 2.19 (d, J = 7.8 Hz, 2H), 2.01 - 1.74 (m, 10H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.15 (s, 2H), 6.99 - 6.85 (m, 2H), 5.09 (d, J = 8.1 Hz, 1H), 4.78 (s, 1H), 4.06 - 433 518.72 3.85 (m, 5H), 3.40 - 3.27 (m, 4H), 2.67 - 2.55 (m, 2H), 2.47 (d, J = 9.1 Hz, 6H), 2.19 (d, J = 9.6 Hz, 2H), 1.91 (d, J = 4.8 Hz, 6H), 1.62 (d, J = 5.5 Hz, 6H).

Compound ESMS H NMR “d St“‘6 ”et 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.16 (s, 2H), 6.99 - 6.84 (m, 2H), 5.11 (d, J = 8.1 434 520.47 Hz, 1H), 4.78 (s, 1H), 4.05 - 3.87 (m, 5H), 3.78 - 3.66 (m, 4H), 3.40 - 3.27 (m, 4H), 2.69 - 2.43 (m, 8H), 2.19 (d, J = 8.2 Hz,2H), 1.91 (d, J = 4.8 Hz, 6H). 1H NMR (400 MHz, CDCI3) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 7.68 (d, J = 2.1 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.4 Hz, 1H), 6.76 (d, J = 2.2 Hz, 1H), 435 461.37 .21 (d, J = 8.4 Hz, 1H), 4.86 — 4.76 (m, 1H), 4.45 — 4.33 (m, 1H), 3.98 — 3.84 (m, 4H), 3.39 — 3.25 (m, 4H), 2.59 (s, 3H), 2.31 — 2.16 (m, 2H), 2.06 — 1.89 (m, 6H). 1H NMR (400 MHz, CDCI3) 6 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 4.88 — 4.70 (m, 2H), 436 449.44 4.32 (s, 1H), 3.98 — 3.85 (m, 4H), 3.41 — 3.27 (m, 4H), 2.53 (s, 3H), 2.40 (s, 3H), 2.26 — 2.14 (m, 2H), 1.99 (s, 3H), 1.94 — 1.88 (m, 6H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, form-d) 6 8.72 (d, J = 2.0 Hz, 1H), 8.65 (d, J :19 Hz, 1H), 8.31 (s, 1H), 7.02 - 6.88 (m, 2H), 6.77 (d, J = 2.6 437 Hz, 1H), 5.42 (d, J = 8.1 Hz, 1H), 4.90 - 4.78 (m, 1H), 4.42 (d, J = 7.8 Hz, 1H), 3.99 - 3.85 (m, 4H), 3.43 - 3.27 (m, 4H), 2.37 - 2.13 (m, 2H), 2.10 - 1.88 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.72 (d, J = 2.0 Hz, 1H), 8.64 (d, J = 1.9 Hz, 1H), 8.28 (s, 1H), 7.72 (s, 1H), 6.94 (dd, J = 16.4, 2.5 438 Hz, 2H), 5.45 (d, J = 8.2 Hz, 1H), 4.76 (d, J = 6.6 Hz, 1H), 4.26 (s, 1H), 4.01 - 3.85 (m, 7H), 3.44 - 3.28 (m, 4H), 2.30 - 2.11 (m, 2H), 2.08 - 1.82 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.71 (d, J = 1.8 Hz, 1H), 8.63 (d, J = 1.8 Hz, 1H), 8.14 (d, J = 5.9 Hz, 1H), 6.98 (d, J = 2.4 Hz, 1H), 6.17 (d, J = 6.0 Hz, 1H), 5.05 (s, 1H), 4.01 — 3.70 (m, 5H), 3.42 — 3.25 (m, 4H), 2.77 (q, J = 7.6 Hz, 2H), 2.32 — 2.16 (m, 2H), 2.04 — 1.80 (m, 6H), 1.32 (t, J = 7.6 Hz, 3H).

WO 59690 Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.60 (d, J :19 Hz, 1H), 7.81 (d, J = 6.3 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.6 Hz, 1H), 6.24 440 436.22 (d, J = 6.2 Hz, 1H), 5.92 (s, 1H), 4.80 (m, 1H), 3.98 (s, 3H), 3.95 - 3.87 (m, 4H), 3.54 (m, 1H), 3.38 - 3.28 (m, 4H), 2.23 (m, 2H), 2.00 - 1.81 (m, 6H). 1H NMR (300 MHz, Chloroform-d) rotomers, 6 8.80 (d, 1H), 8.73 (d, 1H), 7.73 (s, 1H), 7.16 - 6.99 (m, 441 434.35 3H), 4.91 (m, 1H), 3.95 (m, 4H), 3.55 (m, 1H), 3.37 (m, 4H), 2.73 (s, 3H), 2.41 (s, 3H), 2.29 (m, 2H), 2.13 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 7.89 (dd, J = 5.0, 1.4 Hz, 1H), 7.19 - 7.10 (m, 1H), 442 420.4 7.03 - 6.95 (m, 2H), 6.92 (d, J = 2.6 Hz, 1H), 4.80 (m, 1H), 3.96 - 3.87 (m, 4H), 3.79 (m, 1H), 3.51 (m, 1H), 3.38 - 3.29 (m, 4H), 2.51 (m, 3H), 2.25 (m, 2H), 2.00 - 1.87 (m, 6H).

WO 59690 Compound ESMS H NMR 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.01 (s, 1H), 7.89 (d, J = 4.8 Hz, 1H), 7.03 (d, J = 443 420.36 4.8 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.5 Hz, 1H), 4.78 (m, 1H), 3.98 - 3.86 (m, 4H), 3.61 (m, 2H), 3.39 - 3.28 (m, 4H), 2.30 - 2.15 (m, 5H), 1.93 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.60 (d, J :19 Hz, 1H), 8.03 (dd, J = 2.7, 0.9 Hz, 1H), 7.12 - 7.00 (m, 2H), 444 420.28 6.95 (d, J = 2.5 Hz, 1H), 6.90 (d, J = 2.5 Hz, 1H), 4.79 (m, 1H), 4.08 - 3.87 (m, 5H), 3.49 (m, 1H), 3.38 - 3.28 (m, 4H), 2.53 (s, 3H), 2.21 (m, 2H), 1.84 (d, J = 6.8 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.65 (m, 1H), 8.40 (m, 1H), 7.50 (dd, J = 4.5, 2.2 Hz, 1H), 7.03 (s, 1H), 445 6.92 (s, 1H), 6.80 (m, 2H), 4.76 (m, 1H), 4.08 (s, 3H), 3.93 (m, 5H), 3.49 (m, 1H), 3.42 - 3.30 (m, 4H), 2.20 (m, 2H), 1.92 (m, 6H). 2014/024767 Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.60 (d, J :19 Hz, 1H), 7.71 (d, J = 2.4 Hz, 1H), 7.65 (d, J = 2.4 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 6.55 (t, J = 2.4 Hz, 1H), 4.79 (m, 1H), 4.13 (m, 1H), 3.92 (m, 4H), 3.85 (s, 3H), 3.48 (m, 1H), 3.38 - 3.29 (m, 4H), 2.22 (m, 2H), 1.98 - 1.88 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.60 (d, J = 2.0 Hz, 1H), 7.70 (s, 1H), 7.15 (m, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.92 (m, 1H), 6.64 (d, J = 8.8 Hz, 1H), 4.80 (m, 1H), 3.90 (m, 7H), 3.45 - 3.26 (m, 5H), 2.24 - 2.12 (m, 2H), 1.98 - 1.81 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.78 (dd, J = 4.0, 2.0 Hz, 1H), 8.66 (d, J = 2.1 Hz, 1H), 8.55 (s, 1H), 8.06 (s, 1H), 7.02 (d, J = 2.5 Hz, 1H), 6.96 (d, J = 2.5 Hz, 1H), 4.88 (m, 1H), 3.93 (m, 4H), 3.55 (m, 1H), 3.40 (m, 4H), 3.29 (m, 1H), 2.58 (s, 3H), 2.28 (m, 2H), 2.07 (m, 6H).

Compound ESMS H NMR 1H NMR (300 MHz, form-d) rotomers, 6 8.85 (d, 1H), 8.67 d, 1H), 7.92 (d, 1H), 7.07 - 6.96 (m, 2H), 449 43535 4.91 (m, 1H), 4.01 - 3.88 (m, 4H), 3.53 - 3.24 (m, 5H), 2.87 (s, 3H), 2.64 (s, 3H), 2.04 - 1.76 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 7.21 (d, J = 9.2 Hz, 450 1H), 6.99 - 6.87 (m, 3H), 4.87 (m, 1H), 3.98 - 3.82 (m, 5H), 3.39 - 3.29 (m, 4H), 2.51 (s, 3H), 2.30 - 2.22 (m, 2H), 2.11 - 1.84 (m, 6H). 1H NMR (300 MHz, Chloroform-d) rotomers, 6 8.92 (d, J = 1.8 Hz, 1H), 8.77 (d, J :18 Hz, 1H), 8.30 (m, 451 2H), 7.02 - 6.90 (m, 2H), 4.86 (m, 1H), 3.94 (m, 4H), 3.52 - 3.26 (m, 5H), 2.78 (s, 3H), 2.26 (d, J = 11.8 Hz, 2H), 1.90 (m, 6H). 2014/024767 Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 5.01 (s, 2H), 4.91 (t, 452 463.35 J = 2.5 Hz, 2H), 4.79 (s, 1H), 4.49 (s, 1H), 4.16 (s, 1H), 3.99 — 3.82 (m, 4H), 3.40 — 3.25 (m, 4H), 2.53 (s, 3H), 2.29 — 2.15 (m, 2H), 1.96 — 1.80 (m, 6H). 1H NMR (300 MHz, CDCI3) 5 8.69 (s, 1H), 8.62 (s, 1H), 7.89 (d, J = 5.9 Hz, 1H), 6.94 (s, 1H), 6.89 (s, 1H), 5.64 (d, 453 450.43 J = 6.0 Hz, 1H), 4.87 — 4.66 (m, 2H), 3.98 — 3.83 (m, 4H), 3.44 — 3.24 (m, 4H), 3.13 (s, 6H), 2.26 — 2.10 (m, 2H), 2.04 — 1.75 (m, 6H). 1H NMR (300 MHz, CDCI3) 5 8.61 (d, J = 1.8 Hz, 1H), 8.52 (d, J = 1.9 Hz, 1H), 7.69 (s, 1H), 6.86 (d, J = 2.4 Hz, 1H), 6.80 (d, J = 2.2 Hz, 1H), 5.62 454 436.34 (d, J = 6.0 Hz, 1H), 4.83 (s, 1H), 4.69 (s, 1H), 3.91 — 3.74 (m, 4H), 3.36 — 3.10 (m, 4H), 2.86 (d, J = 5.0 Hz, 3H), 2.22 — 2.03 (m, 2H), 1.91 — 1.72 (m, 6H). 2014/024767 Compound ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (300 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 8.05 (d, J = 5.2 Hz, 1H), 6.94 (d, J = 2.5 Hz, 1H), 6.89 (d, J = 2.5 Hz, 1H), 6.39 (d, J = 5.2 Hz, 1H), 455 447.41 .13 (bd, 1H), 4.76 (s, 1H), 4.10 — 3.96 (m, 1H), 3.95 — 3.83 (m, 4H), 3.40 — 3.24 (m, 4H), 2.26 — 2.09 (m, 2H), 1.97 — 1.76 (m, 7H), 1.10 — 1.00 (m, 2H), 1.00 — 0.91 (m, 2H). 1H NMR (300 MHz, CDCI3) 5 8.72 (d, J = 1.9 Hz, 1H), 8.64 (d, J = 1.9 Hz, 1H), 8.23 (d, J = 1.8 Hz, 1H), 6.97 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.4 Hz, 1H), 5.04 (d, J = 7.6 Hz, 1H), 456 465.29 4.81 (s, 1H), 4.21 (s, 1H), 4.02 — 3.82 (m, 4H), 3.44 — 3.26 (m, 4H), 2.33 — 2.10 (m, 3H), 2.06 — 1.82 (m, 6H), 1.19 — 1.11 (m, 2H), 1.06 — 0.97 (m, 2H). 1H NMR (300 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.21 (d, J = 51H NMR (300 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.21 (d, J = 5.1 Hz, 1H), 6.95 (d, J = 2.5 Hz, 1H), 6.90 (d, J 457 437.38 = 2.5 Hz, 1H), 6.45 (d, J = 5.1 Hz, 1H), 5.33 (d, J = 7.6 Hz, 1H), 4.85 — 4.74 (m, 1H), 4.56 (s, 2H), 4.12 — 4.00 (m, 1H), 3.95 — 3.86 (m, 4H), 3.66 (s, 1H), 3.39 — 3.27 (m, 4H), 2.18 (dd, J = 14.1, 8.4 Hz, 2H), 2.01 — 1.83 m, 6H.

WO 59690 1H NMR (300 MHz, CDCI3) 5 8.97 (s, 2H), 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.4 Hz, 1H), 5.54 458 489.41 (d, J = 8.0 Hz, 1H), 4.81 (s, 1H), 4.38 (s, 3H), 4.16 — 4.05 (m, 1H), 4.00 — 3.81 (m, 4H), 3.42 — 3.23 (m, 4H), 2.29 — 2.15 (m, 2H), 2.05 — 1.83 (m, 6H). 1H NMR (300 MHz, CDCI3) 5 8.80 — 8.64 (m, 3H), 8.62 (d, J = 1.9 Hz, 1H), 6.97 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.4 Hz, 1H), 5.69 (d, J = 7.6 Hz, 1H), 459 48941 4.82 (s, 1H), 4.18 (s, 3H), 4.15-4.06 (m, 1H), 4.01 — 3.83 (m, 4H), 3.44 — 3.24 (m, 4H), 2.32 — 2.18 (m, 2H), 2.07 — 1.84 (m, 6H). 1H NMR (300 MHz, CDCI3) 5 9.02 (s, 2H), 8.84 (d, J = 2.0 Hz, 1H), 8.66 (d, J = 2.0 Hz, 1H), 7.01 (d, J = 2.3 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 5.90 460 47537 (d, J = 7.1 Hz, 1H), 4.74 (s, 1H), 4.13 (s, 1H), 4.04 — 3.88 (m, 4H), 3.45 — 3.32 (m, 4H), 2.06 (d, J = 7.5 Hz, 2H), 1.96 — 1.84 (m, 6H). 2014/024767 Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (300 MHz, CDCI3) 5 8.72 (d, J = 1.9 Hz, 1H), 8.64 (d, J = 1.9 Hz, 1H), 8.59 (s, 1H), 8.54 (bd, 1H), 7.37 (d, J = 4.9 Hz, 1H), 6.97 (d, J = 2.5 461 Hz, 1H), 6.93 (d, J = 2.1 Hz, 1H), 5.55 (bd, 1H), 4.83 (s, 1H), 4.14 (s, 1H), 4.00 — 3.89 (m, 4H), 3.42 — 3.29 (m, 4H), 2.30 — 2.18 (m, 2H), 1.96 (s, 6H). 1H NMR (300 MHz, CDCI3) 5 8.69 (d, J = 2.5 Hz, 3H), 8.62 (d, J = 1.9 Hz, 1H), 7.62 (d, J = 2.3 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.4 Hz, 462 1H), 6.52 (d, J = 2.1 Hz, 1H), .37 (d, J = 7.9 Hz, 1H), 4.86 — 4.75 (m, 1H), 4.14 — 4.01 (m, 1H), 3.99 — 3.83 (m, 4H), 3.41 — 3.26 (m, 4H), 2.28 — 2.15 (m, 2H), 2.01 — 1.86 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 4.95 (d, J = 7.1 Hz, 463 1H), 4.78 (s, 1H), 4.23 (d, J = 3.8 Hz, 1H), 3.99 — 3.82 (m, 4H), 3.42 — 3.25 (m, 4H), 2.45 (d, J = 0.6 Hz, 3H), 2.30 (d, J = 2.8 Hz, 3H), 2.26 — 2.14 (m, 2H), 1.99 — 1.86 (m, 6H). nd ESMS H NMR C d St t 1H NMR (300 MHz, CDCI3) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J =19 Hz, 1H), 8.22 (s, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 4.78 464 449.35 (d, J = 7.8 Hz, 2H), 4.62 (t, J = 9.1 Hz, 2H), 4.23 (s, 1H), 3.97 — 3.85 (m, 4H), 3.40 — 3.30 (m, 4H), 3.25 (t, J = 9.1 Hz, 2H), 2.27 — 2.11 (m, 2H), 2.01 — 1.82 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 7.86 (d, J = 2.7 Hz, 1H), 7.78 (s, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.5 465 420.19 Hz, 1H), 6.78 (t, J = 2.1 Hz, 1H), 4.78 (m, 1H), 4.00 - 3.86 (m, 4H), 3.50 (s, 1H), 3.38 - 3.28 (m, 4H), 2.28 (s, 3H), 2.25 - 2.14 (m, 2H), 1.95 - 1.85 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (m, 1H), 8.60 (d, J = 1.9 Hz, 1H), 8.20 (m, 1h), 7.93 (s, 1H), 6.97 - 466 6.89 (m, 3H), 4.77 (m, 1H), 3.92 m, 4H), 3.49 (m, 1H), 3.34 (m, 4H), 2.20 (m, 2H), 1.88 (d, J = 4.1 Hz, 6H), 1.70 (m, 4H). nd ESMS H NMR 1H NMR (400 MHz, CDCI3) 6 8.68 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 7.95 (s, 1H), 6.94 (d, J = 2.5 Hz, 1H), 6.90 (d, J = 2.5 Hz, 1H), 5.00 467 (d, J = 7.9 Hz, 1H), 4.83 — 4.74 (m, 1H), 4.07 — 3.96 (m, 1H), 3.96 — 3.87 (m, 4H), 3.38 — 3.28 (m, 4H), 2.29 (s, 3H), 2.22 — 2.12 (m, 2H), 2.07 (s, 3H), 1.93 — 1.85 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 7.91 (d, J = 2.7 Hz, 1H), 7.73 (dd, J = 8.6, 0.7 Hz, 1H), 7.11 (dd, J = 8.6, 2.8 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.5 Hz, 1H), 5.11 - .02 (m, 2H), 4.85 - 4.75 (m, 1H), 4.75 - 4.67 (m, 2H), 3.98 - 3.86 (m, 4H), 3.54 (s, 1H), 3.40 - 3.27 (m, 4H), 2.31 - 2.15 (m, 2H), 2.00 - 1.83 (m, 6H . 1H NMR (400 MHz, CDCI3) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.03 (s, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 4.77 469 (s, 1H), 4.67 (s, 1H), 4.60 (s, 1H), 4.16 (s, 1H), 4.00 — 3.82 (m, 4H), 3.41 — 3.25 (m, 4H), 3.04 (d, J = 5.0 Hz, 3H), 2.28 — 2.11 (m, 2H), 1.99 — 1.84 (m, 6H).

Compound ESMS H NMR C d St t 1H NMR (400 MHz, CDCI3) 6 8.69 (d, J :19 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 7.88 (d, J = 5.5 Hz, 1H), 7.61 (d, J = 2.1 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.4 Hz, 1H), 470 6.84 (d, J = 5.5 Hz, 1H), 6.70 (d, J = 2.1 Hz, 1H), 4.92 (s, 1H), 4.82 — 4.74 (m, 1H), 4.44 — 4.28 (m, 1H), 3.95 — 3.86 (m, 4H), 3.39 — 3.26 (m, 4H), 2.28 — 2.17 (m, 2H), 2.06 — 1.92 (m, 6H). 1H NMR (300 MHz, form-d) 6 8.62 (d, J = 1.9 Hz, 1H), 8.54 (d, J = 2.0 Hz, 1H), 8.42 (s, 1H), 7.91 (d, J = 13.5 Hz, 1H), 6.93 - 6.78 471 (m, 2H), 4.71 (s, 1H), 4.57 (d, J = 7.9 Hz, 1H), 4.22 (s, 1H), 3.91 - 3.78 (m, 4H), 3.33 - 3.19 (m, 4H), 2.16 (d, J = 6.6 Hz, 2H), 1.96 (s, 3H), 1.91 - 1.77 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.62 (d, J = 1.9 Hz, 1H), 8.54 (d, J =1.9 Hz, 1H), 8.10 (d, J = 0.8 Hz, 1H), 6.92 - 6.77 (m, 2H), 5.36 (dd, J = 7.9, 0.9 Hz, 1H), 4.71 472 (q, J = 5.2, 4.2 Hz, 2H), 3.97 - 3.69 (m, 7H), 3.58 - 3.37 (m, 4H), 3.30 - 3.03 (m, 6H), 2.22 - 2.04 (m, 2H), 1.93 - 1.73 (m, 6H), 1.52 (dtd, J = 12.8, 8.9, 3.8 Hz, 2H), 1.28 - 1.16 (m, 3H). 2014/024767 Compound ESMS H NMR 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 2.0 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.16 (s, 1H), 6.92 (dd, J = 15.4, 2.5 Hz, 2H), 4.77 (d, J = 5.4 Hz, 1H), 4.25 - 4.07 (m, 2H), 3.98 - 3.86 (m, 5H), 3.51 (dd, J = 9.3, 8.2 Hz, 2H), 3.40 - 3.29 (m, 5H), 2.92 (s, 3H), 2.87 - 2.71 (m, 2H), 2.19 (d, J = 7.1 Hz, 2H), 1.91 (t, J = 4.0 Hz, 6H). 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 7.99 (d, J = 1.5 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 4.82 (d, J = 5.5 Hz, 1H), 4.77 (s, 1H), 4.15 (s, 1H), 3.96 — 3.85 (m, 4H), 3.76 — 3.65 (m, 4H), 3.38 — 3.26 (m, 4H), 2.59 — 2.45 (m, 4H), 2.34 (s, 3H), 2.27 — 2.13 (m, 2H), 1.96 — 1.85 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.60 (d, J = 1.9 Hz, 1H), 8.52 (s, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 5.01 475 (d, J = 2.6 Hz, 2H), 4.98 — 4.89 (m, 2H), 4.80 (s, 1H), 4.54 (s, 1H), 4.22 (s, 1H), 3.95 — 3.86 (m, 4H), 3.39 — 3.27 (m, 4H), 2.29 — 2.16 (m, 2H), 1.98 — 1.84 (m, 6H).

WO 59690 Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (400 MHz, CDCI3) 5 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 8.03 (d, J =1.7 Hz, 1H), 6.97 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 5.18 — 5.04 (m, 1H), 4.80 (s, 1H), 3.99 — 3.90 (m, 5H), 3.40 — 3.32 (m, 4H), 2.36 (d, J = 2.4 Hz, 3H), 2.23 — 2.15 (m, 2H), 1.95 — 1.85 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.26 (d, J = 1.7 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 477 1H), 5.07 (d, J = 7.2 Hz, 1H), 4.80 (s, 1H), 4.30 — 4.13 (m, 1H), 3.98 — 3.83 (m, 4H), 3.38 — 3.26 (m, 4H), 2.36 (d, J = 2.8 Hz, 3H), 2.29 — 2.16 (m, 2H), 1.97 — 1.85 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.64 (t, J = 9.6 Hz, 1H), 8.53 (d, J = 1.9 Hz, 1H), 8.02 (d, J = 5.9 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 6.83 (d, J = 2.4 Hz, 478 1H), 6.07 (d, J = 6.0 Hz, 1H), 4.91 (s, 1H), 4.73 (s, 1H), 3.83 (dd, J =17.8, 12.9 Hz, 5H), 3.25 (dd, J =17.8, 13.0 Hz, 4H), 2.14 (dd, J = 8.9, 5.0 Hz, 2H), 1.91 — 1.76 (m, 6H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, form-d) 6 8.62 (d, J = 1.9 Hz, 1H), 8.53 (d, J :19 Hz, 1H), 8.15 (s, 1H), 6.84 (dd, J = 17.3, 2.5 Hz, 2H), 479 4.70 (s, 1H), 4.55 (dd, J = 9.2, 8.3 Hz, 2H), 4.36 (s, 1H), 4.16 (s, 1H), 3.92 - 3.76 (m, 4H), 3.35 - 3.15 (m, 4H), 3.03 - 2.83 (m, 2H), 2.14 (s, 2H), 1.84 (d, J = 5.4 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 2.0 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 8.20 (d, J = 0.9 Hz, 1H), 6.93 (dd, J = 17.6, 2.5 Hz, 2H), 5.65 (d, J = 0.9 Hz, 480 1H), 5.54 - 5.38 (m, 1H), 4.97 (d, J = 8.0 Hz, 1H), 4.80 (s, 1H), 4.04 - 3.85 (m, 5H), 3.81 - 3.62 (m, 3H), 3.41 - 3.24 (m, 4H), 2.62 (s, 1H), 2.31 - 2.11 (m, 2H), 1.90 (dd, J = 8.0, 3.5 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.18 (s, 2H), 6.99 - 6.87 (m, 2H), 5.16 (d, J = 8.1 481 Hz, 1H), 4.78 (s, 1H), 4.03 - 3.87 (m, 5H), 3.80 (t, J = 6.5 Hz, 2H), 3.39 - 3.29 (m, 4H), 2.67 (t, J = 6.5 Hz, 2H), 2.26 - 2.14 (m, 2H), 1.90 (t, J = 6.5 Hz, 6H).

Compound ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (400 MHz, CDCI3)6 8.68 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 7.65 (d, J = 3.6 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 482 454.35 1H), 5.14 (s, 1H), 4.90 (s, 1H), 4.76 (s, 1H), 4.01 — 3.87 (m, 5H), 3.39 — 3.31 (m, 4H), 3.01 (d, J = 5.0 Hz, 3H), 2.23 — 2.12 (m, 2H), 1.99 — 1.81 (m, 6H). 1H NMR (300 MHz, CDCI3): ppm 1.81 — 1.98 (m, 6 H), 2.11 — 2.23 (m, 2 H), 2.29 (s, 6 H), 3.29 — 3.38 (m, 6 H), 3.89 — 483 464.3 3.94 (m, 4 H), 3.98 — 4.08 (m, 1 H), .82 (m, 1 H), .21 (d, J = 7.9 Hz, 1 H), 6.61 (d, J = 5.1 Hz, 1 H), 6.90 (d, J = 2.3 Hz, 1 H) 1H NMR (300 MHz, CDCI3): ppm 1.79 — 1.98 (m, 6 H), 2.13 — 2.26 (m, 2 H), 2.34 (s, 3 H), 2.46 — 2.78 (m, 8 H), 3.28 — 484 3.38 (m, 4 H), 3.60 (s, 2 H), 3.78 — 3.98 (m, 5 H), 4.76 — 4.85 (m, 1 H), 5.10 (brs,1 H), 6.18 (d, J = 6.0 Hz, 1 H), 6.90 (d, J = 2.4 H WO 59690 Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (400 MHz, CDCI3) 5 8.68 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.20 (s, 2H), 6.96 (d, J = 2.3 Hz, 1H), 485 6.90 (d, J = 2.4 Hz, 1H), 5.27 (d, J = 7.4 Hz, 1H), 4.79 (s, 1H), 4.01 — 3.84 (m, 5H), 3.40 — 3.25 (m, 4H), 2.25 — 2.12 (m, 2H), 1.97 — 1.82 (m, 6H). 1H NMR (400 MHz, CDCI3) 6 8.62 (d, J = 1.9 Hz, 1H), 8.54 (d, J = 1.9 Hz, 1H), 8.49 (s, 1H), 8.08 (d, J = 6.0 Hz, 1H), 6.89 (d, J = 2.5 Hz, 1H), 6.83 (d, J = 2.5 Hz, 1H), 6.24 (dd, J = 6.0, 1.1 Hz, 1H), 4.88 (s, 1H), 4.78 - 4.67 (m, 1H), 3.87 - 3.82 (m, 4H), 3.25 (dd, J = 13.6, 8.8 Hz, 4H), 2.15 (dd, J = 8.8, 5.1 Hz, 2H), 1.90 - 1.78 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 8.45 (s, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.87 (t, J = 9.8 Hz, 1H), 4.77 (s, 1H), 4.49 (d, J = 8.0 Hz, 1H), 4.28 (s, 1H), 3.96 — 3.86 (m, 4H), 3.40 — 3.28 (m, 4H), 2.95 — 2.85 (m, 2H), 2.73 — 2.61 (m, 2H), 2.28 — 2.17 (m, 2H), 2.17 — 2.06 (m, 2H), 1.94 — 1.89 (m, 6H).

WO 59690 1H NMR (400 MHz, CDCI3) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.48 (s, 1H), 7.73 (d, J = 2.1 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.4 Hz, 1H), 6.85 (d, J 488 44737 = 2.1 Hz, 1H), 5.29 (d, J = 8.3 Hz, 1H), 4.88 — 4.75 (m, 1H), 4.46 — 4.33 (m, 1H), 3.95 — 3.87 (m, 4H), 3.38 — 3.30 (m, 4H), 2.31 — 2.19 (m, 2H), 2.06 — 1.91 (m, 6H). 1H NMR (400 MHz, CDCI3) 6 8.68 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 7.85 (d, J = 6.1 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 489 450.34 1H), 5.81 (d, J = 6.1 Hz, 1H), 4.92 (s, 1H), 4.75 (s, 1H), 4.02 (s, 1H), 3.97 — 3.86 (m, 4H), 3.32 (dd, J =17.6, 12.8 Hz, 4H), 3.04 (s, 6H), 2.18 (dd, J = 24.2, 17.3 Hz, 2H). 1H NMR (400 MHz, CDCI3) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 7.87 (d, J = 0.7 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 490 435.35 1H), 4.78 (s, 1H), 4.67 (s, 1H), 4.41 — 4.28 (m, 1H), 3.96 — 3.88 (m, 4H), 3.38 — 3.30 (m, 4H), 2.52 (s, 3H), 2.28 — 2.16 (m, 2H), 2.00 (s, 3H), 1.98 — 1.90 (m, 6H). 2014/024767 Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (400 MHz, CDCI3) 5 8.70 (d, J = 1.7 Hz, 1H), 8.61 (d, J = 1.7 Hz, 1H), 8.42 (s, 1H), 6.95 (s, 1H), 6.90 (s, 1H), 491 4.79 (s, 2H), 4.28 (s, 1H), 3.98 — 3.86 (m, 4H), 3.40 — 3.28 (m, 4H), 2.42 (s, 3H), 2.30 — 2.16 (m, 2H), 2.02 (s, 3H), 1.99 — 1.89 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 8.20 (d, J = 0.8 Hz, 1H), 6.97 (d, J = 2.4 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 5.47 (d, J = 1.0 Hz, 1H), 4.76 (d, J = 23.9 Hz, 2H), 4.12 - 3.75 (m, 7H), 3.41 - 3.28 (m, 4H), 3.20 (ddd, J = 13.2, 9.6, 3.2 Hz, 2H), 2.20 (d, J = 6.9 Hz, 2H), 1.91 (d, J = 5.2 Hz, 6H). 1H NMR (400 MHz, DMSO) 5 8.72 (d, J = 1.9 Hz, 1H), 8.57 (d, J = 1.9 Hz, 1H), 7.77 (s, 1H), 7.45 (s, 1H), 7.14 (d, J = 2.4 Hz, 1H), 6.83 (d, J = 2.3 Hz, 1H), 6.15 (d, J = 5.8 Hz, 1H), 4.92 (s, 1H), 4.26 (t, J = 6.1 Hz, 2H), 4.09 — 3.89 (m, 1H), 3.83 — 3.72 (m, 4H), 3.34 (d, J = 7.7 Hz, 4H), 2.57 (t, J = 6.1 Hz, 2H), 2.36 (d, J = 24.2 Hz, 4H), 2.01 (d, J = 17.5 Hz, 2H), 1.76 (d, J = 4.8 Hz, 6H), 1.52— 1.35 m, 6H.

Compound ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (300 MHz, Chloroform-d) 6 8.62 (d, J = 1.9 Hz, 1H), 8.54 (d, J = 1.9 Hz, 1H), 7.82 (d, J = 3.4 Hz, 1H), 6.88 (d, J = 2.5 Hz, 1H), 6.82 (d, J = 2.5 Hz, 1H), 4.96 494 439.23 (d, J = 8.0 Hz, 1H), 4.72 (d, J = 3.1 Hz, 1H), 4.18 (s, 1H), 3.90 - 3.78 (m, 4H), 3.35 - 3.19 (m, 4H), 2.41 (d, J = 0.9 Hz, 3H), 2.13 (q, J = 6.4 Hz, 2H), 1.84 (t, J = 6.3 Hz, 6H). 1H NMR (300 MHz, CDCI3): ppm 1.37 — 1.47 (m, 2 H), 1.51 — 1.60 (m, 4 H), 1.82- 1.99 (m, 6 H), 2.14 — 2.24 (m, 2 H), 495 504.3 2.30 — 2.41 (m, 4 H), 3.29 (s, 2 H), 3.30 — 3.35 (m, 4 H), 3.89 — 3.93 (m, 4 H), 3.96 — 4.06 (m, 1 H), .81 (m, 1 H), .18 (d, J = 1H NMR (300 MHz, CDCI3): ppm 1.38 — 1.49 (m, 2 H), 1.56 — 1.64 (m, 4 H), 1.79— 1.97 (m, 6 H), 2.15 — 2.26 (m, 2 H), 496 2.45 — 2.57 (m, 4 H), 3.28 — 3.38 (m, 4 H), 3.53 (s, 2 H), 3.68 — 3.99 (m, 5 H), 4.76 — 4.85 (m, 1 H), 5.11 (brs,1 H), 6.18 (d, J = 6.0 WO 59690 Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.22 (s, 2H), 7.01 - 6.85 (m, 2H), 5.21 (d, J = 8.1 Hz, 1H), 4.79 (d, J = 5.3 Hz, 1H), 4.11 - 3.87 (m, 5H), 3.35 (q, J = 3.4 Hz, 6H), 2.46 (s, 6H), 2.29 (s, 3H), 2.19 (s, 3H), 2.01 - 1.83 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.72 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.23 (dd, J = 7.6, 0.8 Hz, 1H), 7.85 (d, J = 2.2 Hz, 1H), 6.97 (d, J = 2.5 Hz, 1H), 6.92 (d, J = 2.5 Hz, 1H), 6.12 (dd, J = 2.2, 0.8 Hz, 1H), 6.00 (d, J = 7.6 Hz, 1H), 4.91 (d, J = 7.9 Hz, 1H), 4.81 (s,1H), 4.20 (s, 1H), 4.01 - 3.88 (m, 4H), 3.42 - 3.28 (m, 4H), 2.22 (s, 2H), 1.97 (dd, J = 7.8, 5.5 Hz, 6H . 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.19 (d, J = 0.8 Hz, 1H), 6.93 (dd, J = 16.4, 2.5 Hz, 2H), 5.42 (d, J = 1.0 Hz, 1H), 4.87 - 4.67 (m, 2H), 4.01 - 3.77 (m, 5H), 3.61 (dt, J = 27.3, 5.1 Hz, 6H), 3.41 - 3.26 (m, 4H), 2.73 (t, J = 5.3 Hz, 1H), 2.59 (ddd, J = 6.2, 5.0, 3.7 Hz, 6H), 2.19 (d, J = 6.6 Hz, 2H), 1.89 (t, J = 5.2 Hz, 6H .

Compound ESMS H NMR Compound ure 1H NMR (300 MHz, Chloroform-d) 6 8.64 (d, J = 1.9 Hz, 1H), 8.55 (d, J = 1.9 Hz, 1H), 8.21 (s, 1H), 6.88 (dd, J = 16.1, 2.5 Hz, 2H), 500 461 .24 6.16 (d, J = 8.3 Hz, 1H), 5.98 (s, 1H), 4.80 (d, J = 2.9 Hz, 1H), 3.90 - 3.77 (m, 4H), 3.72 - 3.51 (m, 1H), 3.33 - 3.20 (m, 4H), 2.51 (s, 3H), 2.34 - 1.66 (m, 8H). 1H NMR (300 MHz, Chloroform-d) 6 8.63 (d, J = 1.9 Hz, 1H), 8.55 (d, J :19 Hz, 1H), 6.95 (dd, J = 3.6, 2.3 Hz, 1H), 6.86 (dd, J = 13.7, 501 480.1 5 2.4 Hz, 2H), 6.30 (dd, J = 3.6, 2.0 Hz, 1H), 5.22 (m, 1H), 4.74 (s, 1H), 4.30 (s, 1H), 3.91 - 3.79 (m, 4H), 3.35 - 3.19 (m, 4H), 2.15 (m, 2H), 2.03 - 1.76 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.63 (d, J = 1.9 Hz, 1H), 8.54 (d, J = 2.0 Hz, 1H), 8.25 (s, 1H), 6.88 (d, J = 2.4 Hz, 1H), 6.82 (d, J = 502 462.19 2.5 Hz, 1H), 4.73 (s, 1H), 4.54 (s, 1H), 4.12 (s, 1H), 3.84 (dd, J = 6.0, 3.7 Hz, 4H), 3.37 - 3.19 (m, 5H), 2.17 (d, J = 10.1 Hz, 2H), 1.92 - 1.71 (m, 6H). nd ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (300 MHz, CDCI3): ppm 1.79 F] 1.99 (m, 6 H), 2.15 - 2.26 (m, 2 H), 2.54 - 2.65 (m, 4 H), 3.29 - 3.37 (m, 503 506.3 4 H), 3.58 (s, 2 H), 3.74 - 3.83 (m, 5 H), 3.88 - 3.95 (m, 4 H), 4.75 -4.85 (m, 1 H), 5.11 (br. s, 1 H), 6.19 (d, J = 5.9 Hz,1 H), 6.90 (d, J 1H NMR (300 MHz, CDCI3): ppm 1.40 — 1.49 (m, 2 H), 1.55 — 1.65 (m, 4 H), 1.84-1.96 (m, 6 H), 2.12 — 2.23 (m, 2 H), 504 504.3 2.43 (br. s, 4 H), 3.30 — 3.40 (m, 6 H), 3.88 — 3.95 (m, 4 H), 3.97-4.08 (m, 1 H), 4.75— 4.82 (m, 1 H), 5.17 (d, J = 7.9 Hz, 1 H), 6.68 1H NMR (300 MHz, CDCI3): ppm 1.83 — 1.96 (m, 6 H), 2.13 — 2.23 (m, 2 H), 2.53 (br. s, 4 H), 3.30 — 3.36 (m, 4 H), 3.42 505 (s, 2 H), 3.72 — 3.78 (m, 4 H), 3.88 — 3.95 (m, 4 H), 4.03 (br. s, 1 H), 4.75 -4.82 (m, 1 H), .21 (d, J = 8.0 Hz, 1 H), 6.67 (d, J = 5) H NMR 1H NMR (300 MHz, DMSO- d6): ppm 1.71 - 1.85 (m, 6 H), 1.98 - 2.10 (m, 2 H), 3.33 - 3.38 (m, 4 H), 3.74 - 3.91 (m, 506 5 H), 4.87 - 4.96 (m, 1 H), 6.02 (d, J = 7.2 Hz, 1 H), 6.51 (s, 1 H), 6.83 (d, J = 1.9 Hz, 1 H), 7.14 (d, J :19 Hz, 1 H), 7.94 (s, 1 H), 8.3 1H NMR (300 MHz, : ppm 1.39 — 1.48 (m, 2 H), 1.54 — 1.69 (m, 4 H), 1.83-1.98 (m, 8 H), 2.12 — 2.24 (m, 2 H), 507 2.33 — 2.47 (m, 6 H), 3.31 — 3.35 (m, 4 H), 3.89 — 3.99 (m, 7 H), 4.74 -4.81 (m, 1 H), 4.95 (d, J = 8.2 Hz, 1 H), 6.90 (d, J = 2.3 Hz, 1 1H NMR (300 MHz, CDCI3): ppm 1.82 — 1.98 (m, 8 H), 2.13 — 2.23 (m, 2 H), 2.29 (s, 3 H), 2.35 — 2.62 (m, 10 H), 3.29 — 508 3.37 (m, 4 H), 3.87 — 3.94 (m, H), 3.97 (t, J = 6.3 Hz, 2 H), 4.74 -4.81 (m, 1 H), 4.96 (d, J = 8.1 Hz, 1 H), 6.90 (d, J = 2.3 Hz, 1 H 2014/024767 H NMR 1H NMR (300 MHz, CDCI3) ppm 1.77 - 1.96 (m, 10 H), 2.11 - 2.25 (m, 2 H), 2.57 - 2.65 (m, 4 H), 2.86 (t, J = 5.7 509 Hz, 2 H), 3.31 - 3.35 (m, 4 H), 3.87 - 3.98 (m, 5 H), 4.05 (t, J = 5.7 Hz, 2 H), 4.74 - 4.81 (m, 1 H), 4.98 (d, J = 8.2 Hz, 1 H), 6.90 (d, J = 1H NMR (300 MHz, Chloroform-d) 6 8.95 (d, J = 1.3 Hz, 1H), 8.72 (d, J = 1.9 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 8.14 (s, 1H), 6.95 (dd, J = 16.0, 2.5 Hz, 2H), 6.36 (d, J :13 Hz, 1H), 5.11 (d, J = 7.8 Hz, 1H), 4.83 (dd, J = 5.5, 2.9 Hz, 1H), 4.01 - 3.84 (m, 4H), 3.73 - 3.55 (m, 1H), 3.40 - 3.30 (m, 4H), 2.34 - 2.21 (m, 2H), 2.08 - 1.83 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.63 (d, J = 1.9 Hz, 1H), 8.55 (d, J :19 Hz, 1H), 7.93 (d, J = 1.7 Hz, 1H), 6.85 (dd, J = 16.5, 2.5 Hz, 2H), 4.74 (ddd, J = 21.7, 511 7.5, 3.9 Hz, 2H), 4.09 (p, J = 7.7, 7.2 Hz, 1H), 3.92 - 3.79 (m, 4H), 3.71 (dd, J = 5.7, 3.7 Hz, 4H), 3.57 (dd, J = 5.7, 3.7 Hz, 4H), 3.34 - 3.20 (m, 4H), 2.15 (td, J = 11.0, 10.0, 6.2 Hz, 2H), 1.94 - 1.79 (m, 6H). 2014/024767 Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 7.99 (d, J = 1.8 Hz, 1H), 7.00 - 6.85 (m, 2H), 4.77 (d, J = 6.6 Hz, 2H), 4.14 (q, J = 7.2 Hz, 1H), 4.03 - 3.87 (m, 4H), 3.78 - 3.64 (m, 1H), 3.43 - 3.28 (m, 4H), 3.15 (d, J = 2.5 Hz, 6H), 2.98 - 2.84 (m, 1H), 2.20 (d, J = 11.9 Hz, 2H), 1.94 (p, J = 5.8, 5.3 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 10.85 (d, J = 3.0 Hz, 1H), 8.66 (d, J = 1.9 Hz, 1H), 8.40 (d, J = 2.0 Hz, 1H), 7.22 (t, J = 2.9 Hz, 1H), 6.85 (d, J = 2.4 Hz, 1H), 6.75 513 (d, J = 2.4 Hz, 1H), 6.36 (dd, J = 31,19 Hz, 1H), 5.86 (d, J = 7.8 Hz, 1H), 4.59 (s, 1H), 4.25 (s, 1H), 3.82 (dd, J = 6.0, 3.7 Hz, 4H), 3.24 (dd, J = 6.0, 3.8 Hz, 4H), 1.71 (s, 11H), 1.51 (t, J = 10.1 Hz, 2H). 1H NMR (300 MHz, Chloroform-d) 6 10.96 (s, 1H), 8.64 (d, J = 1.9 Hz, 1H), 8.40 (d, J :19 Hz, 1H), 6.84 (d, J = 2.4 Hz, 1H), 6.75 (d, J = 2.4 Hz, 1H), 6.34 (dd, J = 31,19 Hz, 1H), 6.02 (d, J = 7.8 Hz, 1H), 4.59 (s, 1H), 4.23 (td, J = 8.8, 8.3, 4.2 Hz, 1H), 3.89 - 3.74 (m, 4H), 3.30 - 3.03 (m, 4H), 1.89 - 1.61 (m, 6H), 1.61 - 1.39 (m, 2H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, form-d) 6 9.53 (s, 1H), 8.71 (d, J = 2.0 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 8.35 (s, 1H), 7.06 (dd, J = 3.6, 2.1 Hz, 1H), 7.00 - 6.85 (m, 2H), 6.39 515 446.42 (dd, J = 3618 Hz, 1H), 5.14 (d, J = 8.3 Hz, 1H), 4.82 (s, 1H), 4.40 (d, J = 8.0 Hz, 1H), 4.01 - 3.81 (m, 4H), 3.44 - 3.25 (m, 4H), 2.26 (d, J = 9.8 Hz, 2H), 2.08 - 1.86 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 12.29 (s, 1H), 8.71 (d, J = 1.9 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 8.43 (s, 1H), 7.95 (s, 1H), 7.00 - 6.89 516 447.32 (m, 2H), 6.03 (s, 1H), 4.86 (s, 1H), 4.42 (s, 1H), 3.92 (dd, J = 6.0, 3.7 Hz, 4H), 3.40 - 3.30 (m, 4H), 2.27 (d, J = 10.1 Hz, 2H), 2.07 - 1.88 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 11.28 (s, 1H), 8.75 (d, J = 1.9 Hz, 1H), 8.53 (d, J = 2.0 Hz, 1H), 8.47 (s, 1H), 7.34 (s, 1H), 6.93 (d, J = 2.3 Hz, 1H), 6.82 (d, J = 2.5 517 446.33 Hz, 1H), 1.93 - 1.71 (m, 6H), 6.54 (d, J = 3.0 Hz, 1H), 5.57 (d, J = 7.9 Hz, 1H), 4.64 (s, 1H), 4.33 (s, 1H), 3.90 (t, J = 4.8 Hz, 4H), 3.31 (t, J = 4.9 Hz, 4H), 1.80-1.68 (m, 6H), 1.54 (d, J = 9.2 Hz, 2H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.63 (d, J = 1.9 Hz, 1H), 8.55 (d, J :19 Hz, 1H), 8.32 (s, 1H), 7.42 (d, J = 2.5 Hz, 1H), 6.88 (d, J = 2.5 Hz, 1H), 6.83 (d, J = 2.5 518 447.2 Hz, 1H), 6.58 (d, J = 2.5 Hz, 1H), 5.07 (s, 1H), 4.74 (s, 1H), 4.26 (s, 1H), 3.84 (dd, J = 6.0, 3.7 Hz, 4H), 3.42 - 3.10 (m, 4H), 2.18 (d, J = 10.2 Hz, 2H), 2.06 - 1.70 (m, 6H). 1H NMR (300 MHz, form-d) 6 8.61 (d, J = 1.9 Hz, 1H), 8.54 (d, J :19 Hz, 1H), 8.07 (s, 2H), 6.93 - 6.79 (m, 2H), 5.04 (d, J = 8.1 Hz, 1H), 4.70 (s, 1H), 4.02 - 519 543.21 3.76 (m, 5H), 3.34 - 3.20 (m, 4H), 3.02 - 2.87 (m, 2H), 2.66 (t, J = 6.9 Hz, 2H), 2.53 - 2.42 (m, 2H), 2.35 - 2.22 (m, 1H), 2.10 (td, J = 11.6, 3.0 Hz, 3H), 1.90 - 1.46 (m, 11H). 1H NMR (300 MHz, Chloroform-d) 6 8.61 (d, J = 2.0 Hz, 1H), 8.56 (d, J = 0.6 Hz, 2H), 8.53 (d, J :19 Hz, 1H), 6.86 (d, J = 2.5 Hz, 1H), 520 455.17 4.67 (d, J = 6.1 Hz, 1H), 3.89 - 3.81 (m, 4H), 3.79 (d, J = 0.7 Hz, 2H), 3.31 - 3.17 (m, 4H), 2.60 (s, 1H), 2.20 - 2.03 (m, 2H), 1.79 - 1.59 (m, 6H). 2014/024767 Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.74 (d, J = 1.9 Hz, 1H), 8.66 (d, J = 2.0 Hz, 1H), 7.93 (s, 1H), 6.99 (d, J = 2.4 Hz, 1H), 6.93 (d, J = 521 465.16 2.5 Hz, 1H), 6.20 (d, J = 8.5 Hz, 1H), 4.87 (s, 1H), 4.36 (s, 1H), 3.94 (dd, J = 5.9, 3.8 Hz, 4H), 3.42 - 3.32 (m, 4H), 2.26 (s, 2H), 1.93 (s, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 8.17 (s, 2H), 7.01 - 6.89 (m, 2H), 5.12 (d, J = 8.1 522 552.21 Hz, 1H), 4.80 (s, 1H), 4.09 - 3.86 (m, 5H), 3.63 (t, J = 7.1 Hz, 2H), 3.40 - 3.29 (m, 4H), 3.06 (d, J = 11.3 Hz, 2H), 2.79 (t, J = 7.1 Hz, 2H), 2.39 -2.15 (m, 4H), 2.02 - 1.53 (m, 10H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.18 (s, 2H), 7.02 - 6.86 (m, 2H), 5.12 (d, J = 8.1 523 518.2 Hz, 1H), 4.80 (s, 1H), 4.09 - 3.87 (m, 5H), 3.42 - 3.29 (m, 4H), 3.12 (d, J = 11.2 Hz, 2H), 2.60 - 1.54 (m, 17H), 1.15 (t, J = 7.2 Hz, 3H).

Compound ESMS H NMR nd Structure No. M+H 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 6.91 (d, J = 2.5 Hz, 1H), 6.61 (d, J = 2.5 Hz, 1H), 5.19 — 5.05 (m, 1H), 524 301 .24 3.97 — 3.85 (m, 5H), 3.37 — 3.29 (m, 4H), 2.71 (ddd, J = 16.1, 7.8, 5.0 Hz, 2H), 2.34 (ddd, J = 13.6, 7.0, 4.1 Hz, 2H). 1H NMR (400 MHz, CDCI3) 5 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 8.31 (s, 1H), 8.30 (s, 1H), 6.93 (d, J = 2.4 Hz, 1H), 6.64 — 6.54 (m, 2H), 5.38 (d, J = 5.1 Hz, 1H), 525 379.26 .17 — 5.07 (m, 1H), 4.68 — 4.56 (m, 1H), 3.95 — 3.85 (m, 4H), 3.35 — 3.27 (m, 4H), 2.94 (ddd, J = 13.4, 8.2, 5.1 Hz, 2H), 2.59 (ddd, J = 13.9, 7.0, 4.5 Hz, 2H). 1H NMR (300 MHz, CDCI3): ppm 1.80 — 2.07 (m, 8 H), 2.11 — 2.25 (m, 2 H), 2.39 — 2.76 (m, 6 H), 3.27 — 3.40 (m, 4 H), 526 3.70 — 3.84 (m, 4 H), 3.87 — 3.96 (m, 5 H), 3.99 (t, J = 6.2 Hz, 2 H), 4.73 — 4.82 (m, 1 H), 4.97 (d, J = 8.1 Hz, 1 H), 6.90 (d, J = 2.4 H WO 59690 H NMR 1H NMR (300 MHz, CDCI3): ppm 1.39 — 1.48 (m, 2 H), 1.56 — 1.67 (m, 4 H), 1.78- 1.96 (m, 6 H), 2.14 — 2.25 (m, 2 H), 527 2.44 — 2.52 (m, 4 H), 2.72 (t, J = 6.0 Hz, 2 H), 3.31 — 3.35 (m, 4 H), 3.63 — 3.75 (m, 1 H), 3.90 — 3.93 (m, 4 H), 4.41 (t, J = 6.0 Hz, 2 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.31 (s, 2H), 7.02 - 6.86 (m, 2H), 5.52 (d, J = 8.0 Hz, 1H), 4.81 (dt, J = 6.8, 3.4 528 Hz, 1H), 4.04 (td, J = 8.0, 4.0 Hz, 1H), 3.97 - 3.86 (m, 4H), 3.64 (s, 2H), 3.43 - 3.27 (m, 4H), 2.75 (t, J = 5.4 Hz, 4H), 2.32 - 2.15 (m, 2H), 2.07 (s, 2H), 1.92 (tt, J = 6.7, 3.6 Hz, 8H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.22 (s, 2H), 7.02 - 6.86 (m, 2H), 5.21 (d, J = 8.1 529 Hz, 1H), 4.81 (dt, J = 7.5, 3.7 Hz, 1H), 4.04 (d, J = 6.9 Hz, 1H), 3.96 - 3.82 (m, 4H), 3.41 - 3.30 (m, 4H), 3.27 (s, 2H), 2.24 (m, 8H), 2.07 - 1.77 (m, 6H). 2014/024767 Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.61 (d, J = 1.9 Hz, 1H), 8.53 (d, J :19 Hz, 1H), 8.13 (s, 2H), 6.87 (d, J = 2.5 Hz, 1H), 6.83 (d, J = 2.5 Hz, 1H), 5.10 (d, J = 8.1 Hz, 1H), 4.71 (s, 1H), 3.94 (s, 1H), 3.88 - 3.78 (m, 4H), 3.67 - 3.56 (m, 4H), 3.32 - 3.17 (m, 6H), 2.41 - 2.26 (m, 4H), 2.12 (d, J = 8.7 Hz, 2H), 1.92 - 1.76 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 8.39 (dd, J = 2.7, 0.5 Hz, 1H), 8.04 (d, J = 3.4 Hz, 1H), 6.97 (d, J = 2.5 Hz, 1H), 531 6.92 (d, J = 2.5 Hz, 1H), 5.15 (d, J = 8.1 Hz, 1H), 4.83 (dq, J = 5.1, 2.6 Hz, 1H), 4.25 (dd, J = 8.1, 4.6 Hz, 1H), 3.98 - 3.88 (m, 4H), 3.39 - 3.28 (m, 4H), 2.34 - 2.17 (m, 2H), 2.03 - 1.84 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.13 (d, J = 4.8 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.5 Hz, 532 1H), 6.54 (d, J = 5.2 Hz, 1H), .36 (s, 1H), 4.79 (s, 1H), 4.03 (s, 1H), 3.97 — 3.84 (m, 4H), 3.41 — 3.23 (m, 4H), 2.26 — 2.12 (m, 2H), 1.98 — 1.81 (m, 6H). 2014/024767 Compound ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.60 (d, J = 1.9 Hz, 1H), 7.99 (s, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 6.22 533 441 .25 (d, J = 5.9 Hz, 1H), 5.22 (s, 1H), 4.81 (s, 1H), 4.03 (dt, J = 12.1, 6.2 Hz, 1H), 3.94 — 3.86 (m, 4H), 3.40 — 3.26 (m, 4H), 2.27 — 2.13 (m, 2H), 1.90 (t, J = 17.4 Hz, 6H). 1H NMR (400 MHz, CDCI3) 5 8.69 (s, 1H), 8.61 (s, 1H), 7.89 (d, J = 5.5 Hz, 1H), 6.95 (s, 1H), 6.89 (s, 1H), 5.71 (d, 534 492.39 J = 5.8 Hz, 1H), 4.76 (s, 2H), 4.01 — 3.81 (m, 5H), 3.74 (s, 8H), 3.41 — 3.26 (m, 4H), 2.26 — 2.12 (m, 2H), 1.98 — 1.81 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 7.88 (d, J = 5.7 Hz, 1H), 6.95 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 5.67 (d, J = 5.8 Hz, 1H), 535 505.35 4.84 — 4.63 (m, 2H), 3.99 — 3.83 (m, 5H), 3.82 — 3.73 (m, 4H), 3.37 — 3.27 (m, 4H), 2.49 — 2.40 (m, 4H), 2.33 (s, 3H), 2.23—2.11 (m, 2H), 1.96 — 1.82 (m, 6H).

H NMR 1H NMR (300 MHz, Chloroform-d) 6 8.73 (d, J = 1.9 Hz, 1H), 8.65 (d, J :19 Hz, 1H), 8.30 (s, 1H), 6.97 (dd, J = 15.8, 2.5 Hz, 2H), 6.23 (d, J = 8.2 Hz, 1H), 6.07 (s, 1H), 4.90 (dt, J = 5.1, 2.4 Hz, 1H), 3.99 - 3.88 (m, 4H), 3.72 (dq, J = 9.2, 4.7 Hz, 1H), 3.40 - 3.29 (m, 4H), 2.60 (s, 3H), 2.34 (dt, J = 14.1, 5.2 Hz, 2H), 2.23 - 1.79 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.7 Hz, 1H), 8.60 (d, J = 1.7 Hz, 1H), 8.18 (s, 1H), 6.95 (d, J = 2.2 Hz, 1H), 6.90 (s, 1H), 5.42 (s, 1H), 4.78 (s, 1H), 4.71 (d, J = 8.3 Hz, 1H), 3.98 — 3.87 (m, 4H), 3.83 (s, 1H), 3.65 — 3.48 (m, 4H), 3.41 — 3.24 (m, 4H), 2.54 — 2.42 (m, 4H), 2.33 (s, 3H), .11 (m, 2H), 1.97 — 1.82 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.74 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 7.57 (d, J = 1.6 Hz, 1H), 7.38 (dd, J = 1.7, 0.8 Hz, 538 1H), 7.05 - 6.88 (m, 3H), 5.52 (d, J = 8.1 Hz, 1H), 4.87 (d, J = 4.0 Hz, 1H), 4.47 - 4.31 (m, 1H), 3.98 - 3.88 (m, 4H), 3.42 - 3.30 (m, 4H), 2.35 - 2.21 (m, 2H), 2.16 - 1.88 (m, 6H).

Compound ESMS H NMR “d St“‘6 ”ret 1H NMR (300 MHz, CDCI3): ppm 1.76 — 1.97 (m, 6 H), 2.15 — 2.26 (m, 2 H), 3.31 — 3.35 (m, 4 H), 3.43 (s, 3 H), 3.61 — 539 3.72 (m, 3 H), 3.90 — 3.93 (m, 4 H), 4.45 -4.48 (m, 2 H), 4.76 — 4.82 (m, 1 H), 4.94 (d, J = 7.1 Hz, 1 H), 5.73 (s, 1 H), 6.89 (d, J = 2. 1H NMR (300 MHz, CDCI3): ppm 1.82 — 1.99 (m, 6 H), 2.13 — 2.25 (m, 2 H), 3.29 — 3.38 (m, 4 H), 3.73 (br. s, 1 H), 540 3.84 — 3.98 (m, 4 H), 4.45 (br. s, 1 H), 4.74 -4.84 (m, 1 H), 6.31 (s, 1 H), 6.43 — 6.47 (m, 1 H), 6.91 (d, J = 2.3 Hz, 1 H), 6.93 — 6.99 (m 1H NMR (300 MHz, CDCI3): ppm 1.40 — 1.48 (m, 2 H), 1.56 — 1.67 (m, 4 H), 1.84— 1.99 (m, 6 H), 2.11 — 2.24 (m, 2 H), 541 2.45 — 2.52 (m, 4 H), 2.72 (t, J = 6.2 Hz, 2 H), 3.32 — 3.35 (m, 4 H), 3.90 — 3.93 (m, 4 H), 3.96 — 4.08 (m, 1 H), 4.40 (t, J = 6.2 Hz, 2 2014/024767 Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.63 (d, J = 1.9 Hz, 1H), 8.56 (d, J = 1.9 Hz, 1H), 8.18 (s, 1H), 7.83 (d, J = 6.3 Hz, 1H), 6.96 - 6.80 (m, 3H), 6.23 (d, J = 8.2 Hz, 542 447.25 1H), 4.77 (dd, J = 5.8, 3.3 Hz, 1H), 4.23 (dq, J = 8.6, 4.3 Hz, 1H), 3.89 - 3.75 (m, 4H), 3.35 - 3.20 (m, 4H), 2.20 (d, J = 12.8 Hz, 2H), 2.10 - 1.79 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.53 (s, 1H), 8.18 (s, 2H), 6.96 - 6.80 (m, 2H), 5.14 (d, J = 8.1 Hz,1H), 4.78 (s, 1H), 4.08 - 3.86 (m, 543 518.2 5H), 3.33 (dd, J = 6.0, 3.8 Hz, 4H), 3.07 - 2.94 (m, 2H), 2.71 (s, 3H), 2.35 (s, 3H), 2.26 - 1.97 (m, 4H), 1.99 - 1.57 (m, 11H). 1H NMR (300 MHz, Chloroform-d) 6 8.61 (s, 1H), 8.18 (s, 2H), 7.02 - 6.87 (m, 2H), 5.12 (d, J = 8.2 Hz,1H), 4.80 (s, 1H), 4.05 - 3.87 (m, 544 _\ 518.2 5H), 3.38 - 3.27 (m, 4H), 3.01 (d, J = 11.4 Hz, 3H), 2.74 (s, 3H), 2.36 (s, 3H), 2.20 (m, 2H), 2.06 (m,2H), 2.00 - 1.58 (m, 11H). nd ESMS H NMR 1H NMR (300 MHz, Chloroform-d) 6 8.73 (d, J = 2.0 Hz, 1H), 8.64 (d, J = 2.0 Hz, 1H), 8.39 (s, 1H), 7.92 (s, 545 461.24 1H), 7.05 - 6.89 (m, 2H), 4.88 (s, 1H), 4.06 (s, 3H), 3.94 (dd, J = 6.0, 3.8 Hz, 4H), 3.36 (t, J = 4.9 Hz, 5H), 2.29 (s, 2H), 1.98 (d, J = 35.4 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.62 (d, J = 1.9 Hz, 1H), 8.55 (d, J = 1.9 Hz, 1H), 8.32 (s, 1H), 7.66 (s, 546 461.24 1H), 6.92 - 6.81 (m, 2H), 4.79 (s, 1H), 3.87 - 3.80 (m, 4H), 3.75 (s, 3H), 3.31 - 3.22 (m, 4H), 2.18 (d, J = 12.7 Hz, 2H), 2.08 - 1.75 (m, 6H). 1H NMR (400 MHz, CDCI3) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 7.90 (d, J = 6.0 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.92 (d, J = 2.3 Hz, 1H), 5.89 (d, J = 6.1 Hz, 1H), 547 4.96 (s, 1H), 4.77 (s, 1H), 4.08 — 3.98 (m, 1H), 3.96 — 3.87 (m, 4H), 3.70 — 3.53 (m, 4H), 3.43 — 3.27 (m, 4H), 2.53 — 2.42 (m, 4H), 2.35 (s, 3H), 2.25 — 2.13 (m, 2H), 2.00 — 1.85 (m, 6H). nd ESMS H NMR C d St t 1H NMR (400 MHz, CDCI3) 5 8.70 (d, J = 1.8 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 7.93 (d, J = 5.9 Hz, 1H), 6.96 (d, J = 2.3 Hz, 1H), 6.91 (d, J = 2.3 Hz, 1H), 5.87 (d, J = 6.1 Hz, 1H), 4.97 (s, 1H), 4.77 (s, 1H), 4.02 (s, 1H), 3.97 — 3.88 (m, 4H), 3.83 — 3.70 (m, 4H), 3.63 — 3.52 (m, 4H), 3.39 — 3.27 (m, 4H), 2.25 — 2.12 (m, 2H), 2.01 — 1.85 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.18 (d, J = 5.1 Hz, 1H), 6.98 - 6.89 (m, 2H), 6.42 (d, J = 5.1 Hz, 1H), 5.18 (d, J 549 = 8.0 Hz, 1H), 4.79 (dt, J = 7.9, 3.7 Hz, 1H), 4.11 - 3.87 (m, 5H), 3.42 - 3.25 (m, 4H), 3.00 (dq, J = 9.9, 3.3 Hz, 2H), 2.63 - 2.35 (m, 5H), 2.27 - 2.04 (m, 4H), 1.97 - 1.82 (m, 9H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.16 (s, 2H), 7.05 - 6.83 (m, 2H), 5.14 (d, J = 8.1 Hz, 1H), 4.79 (d, J = 5.3 Hz, 550 1H), 4.10 - 3.85 (m, 5H), 3.41 - 3.28 (m, 4H), 2.87 (tt, J = 12.8, 3.2 Hz, 1H), 2.20 (q, J = 6.2 Hz, 2H), 1.91 (p, J = 3.7, 2.8 Hz, 6H), 1.73 (dd, J = 13.1, 3.2 Hz, 2H), 1.29 (d, J = 24.9 Hz, 12H). nd ESMS H NMR H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.64 (d, J :19 Hz, 1H), 8.20 (d, J = 5.1 Hz, 1H), 7.01 - 6.89 (m, 2H), 6.42 (d, J = 5.1 Hz, 1H), 5.15 (d, J 551 = 7.9 Hz, 1H), 4.80 (s, 1H), 4.05 (s, 1H), 3.97 - 3.88 (m, 4H), 3.43 - 3.31 (m, 4H), 3.24 (d, J = 12.3 Hz, 2H), 2.84 - 2.69 (m, 2H), 2.59 (m, 1H), 2.20 (m, 2H), 1.92 (t, J = 8.2 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.61 (d, J = 2.0 Hz, 1H), 8.53 (d, J = 1.9 Hz, 1H), 7.85 (s, 1H), 6.94 - 6.73 (m, 2H), 5.33 (d, J = 7.9 Hz, 1H), 4.69 (s, 1H), 4.00 - 3.78 (m, 5H), 3.38 (d, J = 1.0 Hz, 2H), 3.33 - 3.20 (m, 4H), 2.19 - 1.99 (m, 2H), 1.83 (h, J = 5.6 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 6.93 (dd, J = 17.8, 2.5 Hz, 2H), 5.07 (s, 1H), 4.78 553 (d, J = 6.2 Hz, 1H), 4.68 (d, J = 7.9 Hz, 1H), 4.03 - 3.90 (m, 4H), 3.87 (s, 3H), 3.71 (s, 1H), 3.42 - 3.28 (m, 4H), 3.13 (s, 6H), 2.27 - 2.00 (m, 2H), 2.00 - 1.79 (m, 6H).

WO 59690 Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.04 (s, 1H), 5.04 (d, J = 8.2 Hz, 1H), 4.79 (s, 1H), 554 462.2 4.09 - 3.90 (m, 5H), 3.85 (s, 2H), 3.42 - 3.31 (m, 4H), 3.11 (t, J = 5.8 Hz, 2H), 2.63 (t, J = .8 Hz, 2H), 2.19 (d, J = 8.1 Hz, 2H), 1.91 (d, J = 5.5 Hz, 6H). 1H NMR (400 MHz, CDCI3) 5 8.68 (d, J :19 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.87 (d, J = 2.4 Hz, 1H), 5.47 (s, 1H), 5.30 (s, 555 357.15 1H), 4.50 (s, 1H), 4.00 — 3.84 (m, 4H), 3.40 — 3.27 (m, 4H), 2.45 — 2.33 (m, 2H), 2.33 — 2.18 (m, 1H), 2.15 — 2.00 (m, 2H), 1.74 (d, J = 5.4 Hz, 4H). 1H NMR (300 MHz, Chloroform-d) 6 8.61 (d, J = 1.9 Hz, 1H), 8.53 (d, J :19 Hz, 1H), 7.97 (s, 1H), 6.92 - 6.77 (m, 2H), 4.95 (d, J = 8.1 Hz, 1H), 4.76 - 4.64 (m, 1H), 556 476.23 3.97 - 3.75 (m, 5H), 3.34 (s, 2H), 3.30 - 3.17 (m, 4H), 2.60 (dq, J = 9.7, 5.3, 4.8 Hz, 4H), 2.37 (s, 3H), 2.10 (td, J = .8, 10.3, 6.1 Hz, 2H), 1.90 - 1.62 (m, 6H).

WO 59690 Compound ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 2.0 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 8.20 (d, J = 5.1 Hz, 1H), 7.01 - 6.89 (m, 2H), 6.40 (d, J = 5.1 Hz, 1H), 5.20 (s, 557 1H), 4.81 (d, J = 6.1 Hz,1H), 4.23 (s, 2H), 4.04 (s, 1H), 3.97 - 3.89 (m, 4H), 3.42 - 3.28 (m, 4H), 2.82 (t, J = 12.8 Hz, 2H), 2.67 - 2.44 (m, 1H), 2.27 - 2.11 (m, 2H), 1.98 - 1.87 (m, 8H), 1.49 (s, 9H). 1H NMR (300 MHz, CDCI3): ppm 1.84 — 1.99 (m, 6 H), 2.11 — 2.25 (m, 2 H), 3.32 — 3.36 (m, 4 H), 3.43 (s, 3 H), 3.70 — 558 3.73 (m, 2 H), 3.90 — 3.93 (m, 4 H), 3.96 —4.07 (m, 1 H), 4.41 —4.44 (m, 2 H), 4.72 — 4.80 (m, 1 H), 5.10 (br. s,1 H), 6.06 (d, J = 5.6 1H NMR (300 MHz, CDCI3): ppm 1.84 — 1.98 (m, 6 H), 2.13 — 2.23 (m, 2 H), 2.32 (s, 6 H), 2.68 (t, J = 5.8 Hz, 2 H), 3.30 — 559 3.37 (m, 4 H), 3.88 — 3.95 (m, 4 H), 3.98 -4.08 (m, 1 H), 4.37 (t, J = 5.8 Hz, 2 H), 4.73 — 4.80 (m, 1 H), 5.05 (d, J = 7.5 Hz, 1 H) Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (300 MHz, CDCI3): ppm 1.83 — 2.00 (m, 8 H), 2.10 — 2.25 (m, 2 H), 2.52 — 2.59 (m, 4 H), 2.78 (t, J = 5.8 Hz, 2 560 536.3 H), 3.31 — 3.38 (m, 4 H), 3.70 — 3.77 (m, 4 H), 3.89 — 3.95 (m, 4 H), 4.03 (br. s, 1 H), 4.41 (t, J = 5.8 Hz, 2 H), 4.72 — 4.80 (m, 1 H), 1H NMR (300 MHz, : ppm 1.78 — 1.94 (m, 8 H), 2.14 — 2.25 (m, 2 H), 2.32 (s, 8 H), 2.87 (t, J = 5.5 Hz, 2 H), 3.28 — 561 3.38 (m, 4 H), 3.88 (br. s, 1 H), 3.84 — 3.98 (m, 4 H), 4.39 (t, J = 5.5 Hz, 2 H), 4.79 (br. s, 1 H), 4.90 (d, J = 7.2 Hz, 1 H), .73 1H NMR (300 MHz, CDCI3): ppm 1.81 — 1.94 (m, 8 H), 2.14 — 2.24 (m, 2 H), 2.28 (s, 3 H), 2.47 (br. s, 4 H), 2.59 (br. s, 4 562 H), 2.78 (t, J = 5.8 Hz, 2 H), 3.30 — 3.37 (m, 4 H), 3.89 (br. s, 1 H), 3.88 — 3.95 (m, 4 H), 4.42 (t, J = 5.8 Hz, 2 H), 4.75 — 4.83 nd ESMS H NMR 1H NMR (400 MHz, CDCI3) 5 8.68 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 8.48 (d, J = 0.6 Hz, 1H), 7.75 (d, J = 2.2 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.92 — 6.88 (m, 1H), 6.67 563 44737 (d, J = 1.4 Hz, 1H), 5.22 (t, J = 9.5 Hz, 1H), 4.79 (s, 1H), 4.06 (s, 1H), 4.00 — 3.84 (m, 4H), 3.40 — 3.24 (m, 4H), 2.16 (t, J = 21.2 Hz, 2H), 1.98 — 1.85 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 8.07 (s, 1H), 6.99 — 6.84 (m, 2H), 5.10 (d, J = 8.1 Hz, 1H), 4.78 (d, J = 5.7 Hz, 564 56225 1H), 4.42 (s, 2H), 4.10 — 3.85 (m, 5H), 3.64 (t, J = 5.6 Hz, 2H), 3.40 — 3.29 (m, 4H), 2.65 (dt, J = 6.2, 2.8 Hz, 2H), 2.19 (q, J = 6.0 Hz, 2H), 1.98 — 1.85 (m, 6H), 1.49 (s, 9H). 1H NMR (300 MHz, Chloroform-d) 6 8.55 (d, J = 1.9 Hz, 1H), 8.47 (d, J = 1.9 Hz, 1H), 6.93 (s, 1H), 6.86 - 6.72 (m, 2H), 5.25 (s, 1H), 4.66 (s, 1H), 4.05 - 3.90 (m, 1H), 3.86 - 3.71 (m, 7H), 3.30 - 3.09 (m, 4H), 2.27 (d, J = 2.2 Hz, 3H), 2.04 (d, J = 9.2 Hz, 2H), 1.75 (d, J = 4.8 Hz, 6H). 2014/024767 Compound ESMS H NMR 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J 2.0 Hz, 2H), 8.63 (d, J =1. Hz, 1H), 7.42 (s, 1H), 7.01 ILOII 566 475.15 6.86 (m, 2H), 5.64 (d, J = 8.2 Hz, 1H), 4.83 (s, 1H), 3.92 (dd, J = 6.0, 3.7 Hz, 4H), 3.34 (dd, J = 5.8, 3.9 Hz, 4H), 2.11 - 1.78 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 7.74 (s, 1H), 7.00 - 6.89 (m, 2H), 4.91 (s, 1H), 567 504.1 4.76 (d, J = 6.1 Hz, 1H), 4.04 - 3.93 (m, 5H), 3.43 - 3.28 (m, 4H), 2.26 - 2.14 (m, 2H), 2.08 (d, J = 0.8 Hz, 3H), 2.00 - 1.92 (m, 6H), 1.69 (d, J = 21.2 Hz, 10H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 2.0 Hz, 1H), 8.22 (s, 2H), 7.04 - 6.88 (m, 2H), 5.14 (d, J = 8.1 Hz, 1H), 4.80 (d, J = 5.5 Hz, 568 1H), 4.09 - 3.85 (m, 5H), 3.41 - 3.31 (m, 4H), 3.29 - 3.13 (m, 1H), 3.04 - 2.92 (m, 1H), 2.81 (q, J = 8.1 Hz, 1H), 2.68 (dt, J = 9.2, 4.6 Hz, 1H), 2.52 - 2.26 (m, 5H), 2.24 - 2.13 (m, 2H), 2.02 - 1.78 (m, 7H). nd ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.61 (d, J = 1.9 Hz, 1H), 8.54 (d, J = 1.9 Hz, 1H), 8.10 (s, 2H), 6.93 - 6.76 (m, 2H), 5.07 (d, J = 8.1 569 476.06 Hz, 1H), 4.68 (d, J = 15.8 Hz, 1H), 4.00 - 3.78 (m, 5H), 3.35 - 3.20 (m, 4H), 3.18 - 2.92 (m, 3H), 2.70 (dd, J = 10.7, 8.4 Hz, 1H), 2.24 - 2.02 (m, 3H), 1.94 - 1.62 (m, 7H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 2.2 Hz, 1H), 8.63 (d, J = 2.1 Hz, 1H), 8.19 (s, 2H), 7.03 - 6.86 (m, 2H), 4.10 - 3.86 (m, 570 576.2 5H), 3.46 - 3.28 (m, 4H), 3.24 - 3.13 (m, 1H), 2.35 - 2.16 (m, 1H), 2.05 - 1.84 (m, 8H), 1.81 - 1.66 (m, 1H), 1.55 - 1.41 (m,11H). 1H NMR (400 MHz, CDCI3) 6 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 7.88 (d, J = 2.4 Hz, 1H), 6.96 (d, J = 2.5 Hz, 1H), 6.90 (d, J = 2.4 Hz, 571 476.31 1H), 6.76 (s, 1H), 4.98 (s, 2H), 4.78 (s, 1H), 4.00 — 3.86 (m, 4H), 3.83 (s, 1H), 3.39 — 3.27 (m, 4H), 2.21 (d, J = 9.6 Hz, 2H), 1.89 (dd, J = 13.3, 8.6 Hz, 6H), 1.50 (s, 6H). nd ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (300 MHz, CDCI3): ppm 1.82 — 1.99 (m, 6 H), 2.14 — 2.28 (m, 2 H), 3.32 — 3.35 (m, 4 H), 3.80 — 3.88 (m, 1 H), 572 472.2 3.90 — 3.93 (m, 4 H), 4.70 — 4.83 (m, 2 H), 6.37 (d, J = 8.8 Hz, 1 H), 6.38 (t, J = 73.8 Hz, 1 H), 6.90 (d, J = 2.3 Hz, 1 H), 6.95 (d, J = 1H NMR (300 MHz, CDCI3): ppm 1.52 (s, 6 H), 1.73 (br s, 1 H), 1.85 - 1.96 (m, 6 H), 2.11 - 2.25 (m, 2 H), 3.30 - 573 464.3 3.36 (m, 4 H), 3.88 - 4.00 (m, H), 4.55 (d, J = 8.1 Hz, 1 H), 4.74 -4.81 (m, 1 H), 6.52 (s, 1 H), 6.57 (dd, J = 5.4, 1.4 Hz, 1 H), 6.90 (d, 1H NMR (400 MHz, CDCI3) 6 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 7.99 (s, 2H), 6.95 (d, J = 2.4 Hz, 1H), 574 6.89 (d, J = 2.4 Hz, 1H), 4.78 (s, 1H), 4.01 — 3.84 (m, 7H), 3.41 (s, 2H), 3.37 — 3.27 (m, 4H), 2.26 — 2.14 (m, 2H), 1.93 — 1.81 (m, 6H).

Compound ESMS H NMR C d St t 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J :19 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.57 (s, 1H), 8.13 (s, 2H), 6.98 (d, J = 2.4 Hz, 1H), 6.91 (d, J = 2.5 Hz, 1H), 4.86 — 4.73 (m, 1H), 3.95 — 3.88 (m, 4H), 3.56 — 3.49 (m, 1H), 3.39 — 3.31 (m, 4H), 2.30 — 2.18 (m, 2H), 1.97 — 1.84 (m, 6H). 1H NMR (300 MHz, form-d) 6 8.71 (d, J = 2.0 Hz, 1H), 8.63 (d, J =1.9 Hz, 1H), 8.13 (s, 1H), 7.01 - 6.87 (m, 2H), 4.81 (s, 1H), 4.57 (s, 2H), 4.06 (s, 1H), 3.99 - 3.87 (m, 4H), 3.35 (dd, J = 5.9, 3.8 Hz, 4H), 2.45 (s, 3H), 2.20 (d, J = 8.0 Hz, 2H), 1.93 (d, J = 5.1 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 2.0 Hz, 1H), 8.02 (d, J = 1.4 Hz, 1H), 7.87 (d, J = 1.5 Hz, 1H), 577 6.94 (dd, J = 16.2, 2.5 Hz, 2H), 4.89 - 4.71 (m, 2H), 4.65 (s, 2H), 4.06 - 3.85 (m, 4H), 3.40 - 3.27 (m, 4H), 2.23 (dt, J = 11.5, 5.5 Hz, 2H), 2.04 - 1.80 (m, 6H). nd ESMS H NMR 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 2.0 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 7.01 - 6.88 (m, 2H), 6.87 - 6.66 (m, 2H), 3.94 (t, J = 4.9 Hz, 4H), 3.65 (s, 3H), 3.42 - 3.30 (m, 4H), 2.19 (s, 2H), 1.91 (d, J = 4.9 Hz, 6H). 1H NMR (400 MHz, CDCI3) 6 8.88 (s, 1H), 8.61 (s, 1H), 8.07 (s, 2H), 8.94 (s, 1H), 6.90 (s, 1H), 4.98 (d, J = 8.1 Hz, 1H), 4.78 (s, 1H), 4.02 — 3.81 (m, 5H), 3.47 — 3.19 (m, 5H), 3.19 — 2.83 (m, 4H), 2.78 — 2.52 (m, 3H), 2.37 (s, 3H), 2.28 — 2.11 (m, 2H), 2.03 — 1.82 (m, 8H). 1H NMR (300 MHz, CDCI3): ppm 1.84 — 2.17 (m, 8 H), 2.23 — 2.35 (m, 2 H), 3.31 — 3.38 (m, 4 H), 3.83 F) 3.75 (m, 1 H), 580 3.87 — 3.98 (m, 4 H), 4.82 — 4.89 (m, 1 H), 5.88 (d, J = 7.2 Hz, 1 H), 8.11 (d, J = 7.8 Hz, 1 H), 8.44 (d, J = 2.2 Hz, 1 H), 6.90 F) 6.95( 2014/024767 Compound ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (300 MHz, CDCI3): ppm 1.85 — 2.18 (m, 6 H), 2.24 — 2.36 (m, 2 H), 3.31 — 3.39 (m, 4 H), 3.64 — 3.77 (m, 1 H), 581 446.3 3.88 — 3.97 (m, 4 H), 4.82 — 4.89 (m, 1 H), 5.91 (d, J = 7.9 Hz, 1 H), 6.12 (d, J = 7.9 Hz, 1 H), 6.93 (d, J = 2.4 Hz, 1 H), 6.98 (d, J = 1H NMR (300 MHz, CDCI3): ppm 1.83 F] 1.96 (m, 6 H), 2.14 - 2.26 (m, 2 H), 3.30 - 3.36 (m, 4 H), 3.41 (s, 3 H), 582 450.3 3.87 F) 3.95 (m, 5 H), 4.36 (s, 2 H), 4.59 - 4.89 (m, 2 H), 6.38 (s, 1 H), 6.48 (d, J = 5.2 Hz, 1 H), 6.90 (d, J = 2.4 Hz, 1 H), 6.95 (d, J = 2.4 1H NMR (300 MHz, CDCI3): ppm 1.84 — 2.00 (m, 6 H), 2.09 — 2.24 (m, 2 H), 3.30 — 3.37 (m, 4 H), 3.64 — 3.74 (m, 1 H), 583 466.3 3.78 (s, 3 H), 3.89 — 3.95 (m, 7 H), 4.71 —4.79 (m, 1 H), 5.88 (d, J = 8.3 Hz, 1 H), 6.90 (d, J = 2.4 Hz, 1 H), 6.95 (d, J = 2.4 Hz, 1 H) nd ESMS H NMR Compound Structure 1H NMR (300 MHz, CDCI3): ppm 1.86 — 2.04 (m, 6 H), 2.12 — 2.26 (m, 2 H), 3.28 — 3.39 (m, 4 H), 3.88 — 3.96 (m, 4 H), 584 436.3 4.26 (br s, 1 H), 4.62 (s, 2 H), 4.69 — 4.78 (m, 1 H), 5.56 (br s, 1 H), 6.50 (t, J = 5.3 Hz, 1 H), 6.90 (d, J = 1.9 Hz, 1 H), 6.93 (d, J 1H NMR (300 MHz, CDCI3): ppm 1.81 — 1.96 (m, 6 H), 2.11 — 2.25 (m, 2 H), 2.56 (br s, 4 H), 2.76 (t, J = 5.3 Hz, 2 H), 585 536.3 3.30 — 3.36 (m, 4 H), 3.74 (t, J = 4.4 Hz, 4 H), 3.88 — 3.96 (m, H), 4.06 (t, J = 5.3 Hz, 2 H), 4.73 -4.81 (m, 1 H), 4.99 (d, J = 7.8 1H NMR (300 MHz, CDCI3): ppm 1.88 F] 2.01 (m, 6 H), 2.10 (s, 3 H), 2.15 - 2.25 (m, 2 H), 3.30 - 3.37 (m, 4 H), 3.89 586 420.3 F) 3.95 (m, 4 H), 4.25 (br s, 2 H), 4.71 -4.78 (m, 1 H), 6.51 (dd, J = 6.8, 5.4 Hz, 1 H), 6.90 (d, J = 2.3 Hz, 1 H), 6.94 (d, J = 2.3 Hz, 1 Compound ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (300 MHz, CDCI3): ppm 1.82 — 1.98 (m, 8 H), 2.12 — 2.28 (m, 2 H), 3.25 — 3.43 (m, 4 H), 3.82 — 3.98 (m, 5 H), 587 474.2 4.80 (br s, 2 H), 8.52 (d, J = 8.4 Hz, 1 H), 8.87 — 8.93 (m, 2 H), 8.95 — 7.00 (m, 1 H), 7.50 (t, J = 7.9 Hz, 1 H), 8.83 (d, J = 1.2 Hz, 1 1H NMR (300 MHz, : ppm 1.38 (t, J = 7.0 Hz, 3 H), 1.83 —2.00 (m, 8 H), 2.11 — 2.24 (m, 2 H), 3.30 — 3.37 (m, 588 450.3 4 H), 3.75 — 3.85 (m, 1 H), 3.89 — 3.94 (m, 4 H), 4.25 (q, J = 7.0 Hz, 2 H), 4.42 — 4.54 (m, 1 H), 4.72—4.79 (m, 1 H), .94 (d, J = 7.7 H 1H NMR (300 MHz, CDCI3): ppm 1.88 — 1.99 (m, 8 H), 2.18 — 2.27 (m, 2 H), 3.31 — 3.38 (m, 4 H), 3.88 — 3.95 (m, 5 H), 589 474.2 4.77 — 4.84 (m, 1 H), 4.90 (br s, 1 H), 8.55 (s, 1 H), 8.72 (d, J = 5.0 Hz, 1 H), 8.91 (d, J = 2.4 Hz, 1 H), 8.95 (d, J = 2.4 Hz, 1 H), 8.

WO 59690 Compound ESMS H NMR 1H NMR (300 MHz, CDCI3): ppm 1.82 — 1.98 (m, 6 H), 2.10 — 2.22 (m, 2 H), 3.31 — 3.35 (m, 4 H), 3.41 — 3.45 (m, 4 H), 590 491.3 3.69 — 3.82 (m, 5 H), 3.90 — 3.93 (m, 4 H), 4.43 (d, J = 7.7 Hz, 1 H), 4.70 —4.77 (m, 1 H), .81 (d, J = 8.0 Hz, 1 H), 5.90 (d, J = 8.0 H 1H NMR (300 MHz, CDCI3): ppm 1.88 — 2.00 (m, 6 H), 2.13 — 2.28 (m, 2 H), 3.29 — 3.38 (m, 4 H), 3.88 — 3.95 (m, 4 H), 591 4.21 (brs, 1 H), 4.62 -4.84 (m, 2 H), 6.45 — 6.54 (m, 1 H), 6.90 (d, J = 2.4 Hz, 1 H), 6.95 (d, J = 2.4 Hz, 1 H), 7.07 — 7.18(m, 1 H), 1H NMR (300 MHz, CDCI3): ppm 1.84 — 2.03 (m, 6 H), 2.11 — 2.24 (m, 2 H), 3.30 — 3.37 (m, 4 H), 3.84 (s, 3 H), 3.89 — 592 3.95 (m, 4 H), 4.17 — 4.29 (m, 1 H), 4.67-4.76 (m, 1 H), .08 (d, J = 7.4 Hz, 1 H), 6.50 (dd, J = 7.3, 5.2 Hz, 1 H), 6.82 (d, J = 7.4 Hz Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (300 MHz, CDCI3): ppm 1.88 — 2.00 (m, 8 H), 2.13 — 2.28 (m, 2 H), 3.30 — 3.38 (m, 4 H), 3.88 — 3.97 (m, 4 H), 593 474.2 .35 (m, 1 H), 4.73— 4.80 (m, 1 H), 4.89 — 4.99 (m, 1 H), 8.80 (dd, J = 7.1, 5.1 Hz, 1 H), 8.91 (d, J = 2.3 Hz, 1 H), 8.98 (d, J = 1H NMR (300 MHz, CDCI3): ppm 1.85 — 2.00 (m, 8 H), 2.11 — 2.28 (m, 2 H), 3.29 — 3.39 (m, 4 H), 3.87 — 3.97 (m, 4 H), 594 4.08 —4.18 (m, 1 H), 4.58 (d, J = 7.8 Hz, 1 H), 4.73 —4.81 (m, 1 H), 8.90 (d, J = 2.4 Hz, 1 H), 8.95 (d, J = 2.4 Hz, 1 H), 7.05 (ddd, J = 1H NMR (300 MHz, CDCI3): ppm 1.88 — 2.02 (m, 8 H), 2.08 (s, 3 H), 2.15 (s, 3 H), 2.14 — 2.24 (m, 2 H), 3.31 — 3.38 (m, 595 4 H), 3.89 — 3.95 (m, 4 H), 4.03 —4.18 (m, 1 H), 4.23 (br s, 1 H), 4.89 —4.77 (m, 1 H), 8.90 (d, J = 2.4 Hz, 1 H), 8.94 (d, J = 2.4 Hz nd ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 2.0 Hz, 1H), 8.63 (d, J = 2.0 Hz, 1H), 6.99 (d, J = 2.4 Hz, 1H), 6.92 (t, J = 2.8 Hz, 1H), 596 6.08 (d, J = 1.1 Hz, 1H), 5.21 (s, 1H), 4.81 (s, 2H), 3.98 - 3.87 (m, 4H), 3.43 - 3.30 (m, 4H), 2.51 (d, J = 1.0 Hz, 3H), 2.19 (s, 2H), 2.01 - 1.77 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 7.07 - 6.87 (m, 2H), 6.02 (s, 1H), 4.83 (d, J = 5.5 597 Hz, 1H), 4.03 - 3.81 (m, 5H), 3.44 - 3.25 (m, 4H), 2.72 - 2.57 (m, 1H), 2.51 (s, 3H), 2.29 - 2.11 (m, 2H), 2.05 - 1.72 (m, 6H), 1.27 (t, J = 7.6 Hz, 3H). 1H NMR (300 MHz, Chloroform-d) 6 8.61 (d, J = 1.9 Hz, 1H), 8.54 (d, J :19 Hz, 1H), 6.93 - 6.72 (m, 3H), 598 6.55 (s, 1H), 4.71 (s, 1H), 4.01 (s, 1H), 3.92 - 3.76 (m, 4H), 3.34 - 3.18 (m, 4H), 2.98 (s, 6H), 2.07 (d, J = 24.1 Hz, 2H), 1.87 (d, J = 9.2 Hz, 6H). nd ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.62 (d, J = 1.9 Hz, 1H), 8.54 (t, J = 2.4 Hz, 1H), 6.85 (dd, J = 18.9, 599 2.4 Hz, 2H), 6.63 - 6.50 (m, 1H), 4.68 (s, 1H), 3.92 - 3.76 (m, 4H), 3.66 (s, 1H), 3.32 - 3.17 (m, 4H), 2.16 - 1.99 (m, 5H), 1.92 - 1.72 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 2.0 Hz, 1H), 8.62 (d, J = 2.0 Hz, 1H), 7.00 - 6.85 (m, 2H), .44 (d, J = 8.5 Hz, 1H), 4.78 (s, 1H), 3.93 (t, J = 4.8 Hz, 4H), 3.35 (t, J = 4.9 Hz, 4H), 3.06 - 2.91 (m, 1H), 2.15 (d, J = 26.6 Hz, 2H), 1.89 (s, 6H), 1.30 - 0.94 (m, 4H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 7.06 (d, J = 9.1 Hz, 1H), 6.98 - 6.86 (m, 2H), 6.58 (d, J = 9.1 Hz, 1H), 4.81 (dq, J 601 = 5.5, 2.7 Hz, 1H), 4.52 (s, 1H), 4.17 (d, J = 5.0 Hz,1H), 4.01 - 3.87 (m, 4H), 3.67 (dq, J = 8.9, 8.1 Hz, 1H), 3.43 - 3.30 (m, 4H), 2.47 - 2.29 (m, 4H), 2.22 (dt, J = 11.9, 5.5 Hz, 2H), 2.05 - 1.82 (m, 6H). 2014/024767 Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 7.04 - 6.92 (m, 2H), 4.82 (d, J = 3.0 Hz, 1H), 3.93 602 464.1 (dd, J = 5.9, 3.8 Hz, 4H), 3.65 (d, J = 8.7 Hz, 1H), 3.44 - 3.29 (m, 4H), 3.08 (s, 6H), 2.39 (s, 3H), 2.21 (d, J = 14.4 Hz, 2H), 1.92 (dt, J = 17.0, 10.7 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.18 (s, 1H), 7.02 - 603 450.1 6.86 (m, 2H), 4.81 (s, 2H), 4.00 - 3.76 (m, 5H), 3.42 - 3.26 (m, 4H), 3.07 (s, 6H), 2.20 (q, J = 6.3, 5.8 Hz, 2H), 2.01 - 1.79 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.62 (d, J = 1.9 Hz, 1H), 8.53 (d, J :19 Hz, 1H), 6.87 (d, J = 2.5 Hz, 1H), 6.81 (d, J = 2.6 Hz, 1H), 4.71 (s, 1H), 3.94 - 3.72 (m, 7H), 3.25 (dd, J = 5.8, 3.8 Hz, 4H), 2.29 (d, J = 10.4 Hz, 3H), 2.21 - 2.02 (m, 2H), 1.93 - 1.71 (m, 6H).

WO 59690 Compound ESMS H NMR Compound Structure No. M+H 1H NMR (300 MHz, Chloroform-d) 6 9.41 (s, 1H), 8.20 (dd, J = 4.8, 2.4 Hz, 2H), 6.98 - 6.77 (m, 3H), 6.44 (dt, J 606 = 7.5, 4.8 Hz, 2H), 4.71 (s, 2H), 3.83 (dd, J = 5.7, 4.0 Hz, 6H), 3.27 (dt, J = 30.0, 4.9 Hz, 5H), 2.13 (s, 2H), 2.00 - 1.68 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 7.79 (d, J = 2.9 Hz, 1H), 6.93 (dd, J = 17.8, 2.5 Hz, 2H), 5.19 - 5.07 (m, 1H), 4.80 (dt, J = 6.7, 3.4 Hz, 1H), 4.32 (q, J = 7.1 Hz, 3H), 3.98 - 3.87 (m, 4H), 3.41 - 3.29 (m, 4H), 2.30 - 2.13 (m, 2H), 2.03 - 1.84 (m, 6H), 1.41 (t, J = 7.1 Hz, 3H).

Compound ESMS H NMR 1H NMR (300 MHz, form-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 2.0 Hz, 1H), 6.94 (dd, J = 18.9, 2.5 Hz, 2H), 5.42 (d, J = 8.4 Hz, 1H), 4.79 (s, 1H), 4.22 - 4.06 (m, 1H), 4.03 - 3.89 (m, 10H), 3.42 - 3.22 (m, 4H), 2.19 (m, 2H), 2.01 - 1.79 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.72 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 7.03 - 6.84 (m, 2H), 609 5.66 (d, J = 9.1 Hz, 1H), 4.82 (s, 1H), 4.09 - 3.84 (m, 7H), 3.35 (dd, J = 5.5, 3.6 Hz, 4H), 2.20 (s, 2H), 1.91 (d, J = 6.4 Hz, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.51 (s, 2H), 6.95 (d, J = 2.5 Hz, 1H), 6.91 (d, J = 2.6 Hz, 1H), 5.39 (d, J = 8.1 Hz, 1H), 4.88 (d, J = 1.8 Hz, 4H), 4.80 (d, J = 6.2 Hz, 1H), 4.13 - 3.98 (m, 1H), 3.96 - 3.89 (m, 4H), 3.38 - 3.30 (m, 4H), 3.06 (s, 1H), 2.28 - 2.11 (m, 2H), 1.98 - 1.84 (m, 6H). nd ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (300 MHz, Chloroform-d) 6 8.67 (d, J = 1.9 Hz, 1H), 8.60 (d, J = 1.9 Hz, 1H), 6.91 (dd, J = 16.1, 2.5 Hz, 2H), 4.81 (q, J = 3.6, 2.4 Hz, 1H), 4.03 - 3.75 (m, 4H), 3.59 (d, J = 2.9 Hz, 2H), 3.45 - 3.28 (m, 4H), 2.20 (dt, J = 9.5, 4.6 Hz, 2H), 1.74 - 1.23 (m, 7H) 1.41 (s,1H). 1H NMR (300 MHz, CDCI3): ppm 1.83 — 1.96 (m, 6 H), 2.14 — 2.24 (m, 2 H), 3.31 — 3.35 (m, 4 H), 3.44 (s, 3 H), 3.69 — 612 3.72 (m, 2 H), 3.89 — 3.95 (m, H), 4.06 —4.09 (m, 2 H), 4.74-4.83 (m, 1 H), 5.04— .15 (m, 1 H), 6.90 (d, J = 2.4 Hz, 1 H), 6.94 (d, 1H NMR (300 MHz, CDCI3): ppm 1.39 - 1.75 (m, 6 H), 1.82 - 1.95 (m, 6 H), 2.11 - 2.24 (m, 2 H), 2.37 - 2.63 (m, 613 4 H), 2.67 - 2.90 (m, 2 H), 3.33 (t, J = 4.7 Hz, 4 H), 3.87 - 3.97 (m, 5 H), 4.01 - 4.20 (m, 2 H), 4.74 - 4.82 (m, 1 H), 4.98 (d, J = 7.9 Hz, 1 Compound ESMS H NMR 1H NMR (300 MHz, CDCI3): ppm 1.83 — 1.95 (m, 6 H), 2.12 — 2.26 (m, 2 H), 3.30 — 3.40 (m, 4 H), 3.85 — 3.96 (m, 5 H), 614 4.55-4.68 (m, 1 H), 4.74— 4.82 (m, 1 H), 6.10 (dd, J = 7718 Hz, 1 H), 6.18 (dd, J = 8018 Hz, 1 H), 6.90 (d, J = 1.8 Hz, 1 H), 6 1H NMR (300 MHz, : ppm 1.82 — 2.10 (m, 7 H), 2.14 — 2.29 (m, 2 H), 3.26 — 3.40 (m, 4 H), 3.82 — 4.05 (m, 5 H), 615 4.64 (s, 2 H), 4.75 — 4.84 (m, 1 H), 4.85 — 5.13 (m, 1 H), 6.46 (s, 1 H), 6.51 (d, J = 5.3 Hz, 1 H), 6.90 (d, J = 1.7 Hz, 1 H), 6.94 (d, 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 6.95 (dd, J = 16.6, 2.5 Hz, 2H), 6.30 (s, 1H), 5.02 616 (s, 1H), 4.82 (s, 1H), 4.38 (d, J = 0.9 Hz, 2H), 3.99 - 3.83 (m, 5H), 3.39 - 3.24 (m, 4H), 2.49 (s, 3H), 2.33 - 2.11 (m, 2H), 1.91 (q, J = 9.0, 6.9 Hz, 6H).

Compound ESMS H NMR nd Structure 1H NMR (300 MHz, Chloroform-d) 6 8.63 (s, 1H), 8.20 (d, J = 4.8 Hz, 2H), 6.90 (dd, J = 16.2, 2.5 Hz, 2H), 6.44 (t, J = 4.8 Hz, 1H), 5.15 617 437.1 (d, J = 8.1 Hz, 1H), 4.90 (d, J = 3.9 Hz, 2H), 4.79 - 4.64 (m, 1H), 3.99 - 3.71 (m, 6H), 3.32 - 3.19 (m, 4H), 2.21 - 2.04 (m, 2H), 1.95 - 1.70 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.63 (d, J = 1.9 Hz, 1H), 8.55 (d, J :19 Hz, 1H), 6.86 (dd, J = 16.5, 2.5 Hz, 2H), 5.94 (s, 1H), 4.73 618 463.13 (s, 1H), 3.85 (dd, J = 5.9, 3.7 Hz, 4H), 3.35 - 3.20 (m, 4H), 2.67 - 2.51 (m, 2H), 2.26 (s, 3H), 2.09 (d, J = 36.8 Hz, 3H), 1.94 - 1.59 (m, 6H), 0.91 (t, J = 7.4 Hz, 3H).

Chloroform-d) 6 8.77 (s, 1H), 8.29 (d, J = 4.7 Hz, 2H), 7.02 (d, J = 2.5 Hz, 1H), 6.97 (d, J = 2.5 Hz, 1H), 6.53 (t, J = 4.8 619 I1H NMR (300 MHz, Hz, 1H), 5.16 (dd, J = 16.9, 7.5 Hz, 2H), 4.81 (s, 1H), 3.93 (t, J = 4.8 Hz, 5H), 3.34 (t, J = 4.9 Hz, 4H), 2.27 (d, J = 21.1 Hz, 2H), 2.06 - 1.76 (m, 6H), 1.66 (d, J = 6.6 Hz, 3H).

Compound ESMS H NMR Compound Structure 1H NMR (300 MHz, form-d) 6 10.21 (s, 1H), 9.26 (s, 1H), 8.30 (d, J = 4.8 Hz, 2H), 7.09 - 6.88 (m, 2H), 6.54 (t, J = 4.8 Hz, 1H), 4.89 620 435.1 (dq, J = 4.9, 2.5 Hz, 1H), 4.04 (q, J = 6.5 Hz, 1H), 3.99 - 3.87 (m, 5H), 3.55 - 3.39 (m, 5H), 2.35 - 2.17 (m, 3H), 2.09 - 1.82 (m, 6H). 1H NMR (400 MHz, CDCI3) 5 8.68 (d, J = 1.7 Hz, 1H), 8.61 (d, J = 1.7 Hz, 1H), 7.95 (s, 1H), 6.94 (d, J = 2.1 Hz, 1H), 6.90 (s, 1H), 5.12 (d, J = 7.5 621 449.55 Hz, 1H), 4.77 (s, 1H), 4.60 (t, J = 8.5 Hz, 2H), 4.00 (s, 1H), 3.94 — 3.84 (m, 4H), 3.38 — 3.27 (m, 4H), 3.11 (t, J = 8.3 Hz, 2H), 2.25 — 2.10 (m, 2H), 1.97 — 1.82 (m, 6H). 1H NMR (300 MHz, CDCI3): ppm 1.81 — 1.98 (m, 6 H), 2.13 — 2.25 (m, 2 H), 3.29 — 3.38 (m, 4 H), 3.75 — 3.85 (m, 1 H), 622 424.2 3.88 — 3.96 (m, 4 H), 4.56 — 4.71 (m, 1 H), 4.75 — 4.83 (m, 1 H), 6.36 (dd, J = 9.1, 3.3 Hz, 1 H), 6.90 (d, J = 1.9 Hz, 1 H), 6.95 (d, J = 2014/024767 Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (300 MHz, CDCI3): ppm 1.80 — 1.98 (m, 6 H), 2.13 — 2.23 (m, 2 H), 2.38 (s, 3 H), 3.25 — 3.37 (m, 4 H), 3.62 — 623 420.3 3.77 (m, 1 H), 3.88 — 3.97 (m, 4 H), 4.76 -4.83 (m, 1 H), 6.23 (d, J = 7.9 Hz, 1 H), 6.43 (d, J = 7.3 Hz, 1 H), 6.91 (d, J = 2.5 Hz, 1 H) 1H NMR (300 MHz, CDCI3): ppm 1.78 — 2.01 (m, 6 H), 2.11 — 2.24 (m, 2 H), 2.33 (s, 6 H), 2.38 — 2.45 (m, 1 H), 2.69 (t, J 624 ‘ 494.3 = 5.2 Hz, 2 H), 3.26 — 3.42 (m, 4 H), 3.84 — 3.98 (m, 4 H), 4.01 (t, J = 5.2 Hz, 2 H), 4.72 — 4.83 (m, 1 H), 4.97 (d, J = 7.5 Hz, 1 H) 1H NMR (300 MHz, CDCI3): ppm 1.81 - 1.95 (m, 6 H), 2.11 - 2.26 (m, 2 H), 3.31 - 3.35 (m, 4 H), 3.44 (s, 3 H), 625 480.3 3.69 - 3.73 (m, 2 H), 3.76 - 3.84 (m, 1 H), 3.89 - 3.93 (m, 4 H), 4.04 - 4.08 (m, 2 H), 4.44 (br s, 1 H), 4.74 - 4.81 (m, 1 H), 6.37 (d, J = 8.9 nd ESMS H NMR 1H NMR (300 MHz, CDCI3): ppm 1.81 — 1.98 (m, 6 H), 2.12 — 2.25 (m, 2 H), 2.37 — 2.48 (m, 3 H), 2.58 — 2.77 (m, 4 H), 626 3.04 — 3.16 (m, 4 H), 3.28 — 3.37 (m, 4 H), 3.77 — 3.85 (m, 1 H), 3.87 — 3.97 (m, 4 H), 4.32—4.51 (m, 1 H), 4.73— 4.83 (m, 1 H), 6.38( 1H NMR (300 MHz, CDCI3): ppm 1.81 — 2.03 (m, 7 H), 2.12 — 2.28 (m, 2 H), 3.28 — 3.39 (m, 4 H), 3.81 (s, 3 H), 3.87 — 627 3.98 (m, 5 H), 4.76 — 4.84 (m, 1 H), 5.87 (d, J = 1.5 Hz, 1 H), 6.21 (dd, J = 5915 Hz, 1 H), 6.91 (d, J = 1.7 Hz, 1 H), 6.95 (d, J =1 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J = 1.9 Hz, 1H), 6.94 (dd, J = 14.6, 628 2.5 Hz, 2H), 5.57 (s, 1H), 4.86 - 4.72 (m, 1H), 4.02 - 3.86 (m, 4H), 3.50 - 3.26 (m, 5H), 2.65 (s, 3H), 2.32 - 2.06 (m, 2H), 2.06 - 1.73 (m, 6H). nd ESMS H NMR C°mp°”“d St“‘6 ”et 1H NMR (300 MHz, CDCI3) 6 8.62 (s, 1H), 8.54 (s, 1H), 8.15 — 7.93 (m, 1H), 7.40 (d, J = 8.0 Hz, 1H), 6.88 (s, 1H), 6.84 (s, 1H), 6.34 (d, J = 8.6 629 518.4 Hz, 1H), 4.83 — 4.56 (m, 2H), 4.40 — 4.22 (m, 1H), 4.00 — 3.62 (m, 5H), 3.47 — 3.04 (m, 7H), 2.24 — 2.02 (m, 2H), 1.96 — 1.70 (m, 6H). 1H NMR (400 MHz, CDCI3) 6 8.68 (d, J = 1.8 Hz, 1H), 8.59 (d, J = 1.8 Hz, 1H), 8.06 (s, 1H), 7.55 (d, J = 8.3 Hz, 1H), 6.94 (d, J = 2.3 Hz, 1H), 6.89 (d, J = 2.2 Hz, 1H), 6.41 (d, J 630 504.22 = 8.7 Hz, 1H), 4.88 (dd, J = 13.4, 6.7 Hz, 1H), 4.85 — 4.71 (m, 2H), 3.98 — 3.85 (m, 5H), 3.39 — 3.28 (m, 4H), 2.25 — 2.12 (m, 2H), 1.94 — 1.82 (m, 6H). 1H NMR (400 MHz, CDCI3) 6 8.68 (d, J = 1.7 Hz, 1H), 8.61 (d, J :18 Hz, 1H), 7.01 (d, J = 8.4 Hz, 1H), 6.94 (d, J = 2.3 Hz, 1H), 6.89 (s, 1H), 5.96 (d, J = 8.4 Hz, 1H), 4.75 (s, 1H), 631 464.53 4.43 — 4.35 (m, 2H), 4.22 (s, 1H), 4.19 — 4.10 (m, 2H), 3.98 — 3.86 (m, 4H), 3.82 (s, 1H), 3.36 — 3.28 (m, 4H), 2.23 — 2.08 (m, 2H), 1.94 — 1.79 (m, 6H). 2014/024767 Compound ESMS H NMR C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 7.98 (s, 1H), 7.02 - 6.85 (m, 2H), 5.04 (d, J = 8.2 Hz, 1H), 4.79 (s, 1H), 4.02 (s, 632 476.44 1H), 3.96 - 3.87 (m, 4H), 3.40 - 3.25 (m, 4H), 2.82 (t, J = 5.9 Hz, 2H), 2.73 (t, J = 5.8 Hz, 2H), 2.48 (s, 3H), 2.19 (d, J = 8.5 Hz, 2H), 1.91 (d, J = 5.3 Hz, 5H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.18 (d, J = 5.1 Hz, 1H), 7.01 - 6.88 (m, 2H), 6.42 (d, J = 5.1 Hz, 1H), 5.15 (d, J = 8.0 Hz, 1H), 4.79 (d, J = 5.7 633 435.2 Hz, 1H), 4.17 - 4.00 (m, 1H), 3.98 - 3.83 (m, 4H), 3.67 (td, J = 6.7, 4.0 Hz, 1H), 3.42 - 3.31 (m, 4H), 2.59 (q, J = 7.6 Hz, 2H), 2.20 (q, J = 6.1 Hz, 2H), 2.03 - 1.86 (m, 6H), 1.26 (t, J = 7.6 Hz, 3H 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.63 (d, J :19 Hz, 1H), 8.19 (d, J = 5.1 Hz, 1H), 7.01 - 6.88 (m, 2H), 6.42 (d, J = 5.2 Hz, 1H), 5.14 (d, J 634 449.2 = 7.9 Hz, 1H), 4.80 (dt, J = 7.8, 3.8 Hz, 1H), 4.06 (d, J = 4.1 Hz, 0H), 3.99 - 3.85 (m, 4H), 3.46 - 3.24 (m, 4H), 2.78 (hept, J = 7.0 Hz, 1H), 2.34 - 2.11 (m, 2H), 2.04 - 1.81 (m, 7H), 1.25 (d, J = 7.0 Hz, 6H).

Compound ESMS H NMR C d St t 1H NMR (300 MHz, form-d) 6 8.63 (d, J = 1.9 Hz, 1H), 8.54 (d, J :19 Hz, 1H), 6.85 (dd, J = 17.6, 2.5 Hz, 2H), 5.86 - 5.70 (m, 635 481 .05 1H), 4.89 - 4.67 (m, 2H), 3.94 - 3.77 (m, 5H), 3.34 - 3.20 (m, 4H), 3.02 (q, J = 7.3 Hz, 2H), 2.27 - 2.04 (m, 5H), 1.93 - 1.63 (m, 6H), 1.30 (t, J = 7.3 Hz, 3H). 1H NMR (300 MHz, Chloroform-d) 6 8.63 (d, J = 1.9 Hz, 1H), 8.54 (d, J :19 Hz, 1H), 6.86 (dd, J = 16.2, 2.5 Hz, 2H), 5.85 (s, 1H), 4.75 636 461.1 (d, J = 5.5 Hz, 1H), 3.96 - 3.76 (m, 4H), 3.34 - 3.19 (m, 4H), 2.41 (s, 3H), 2.13 (d, J = 8.5 Hz, 2H), 1.82 (q, J = 10.2, 8.8 Hz, 6H), 1.58 - 1.33 (m, 3H), 1.03 - 0.86 (m, 3H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 7.02 - 6.82 (m, 2H), .41 (d, J = 0.8 Hz, 1H), 4.76 (td, J = 5.9, 3.0 Hz, 1H), 4.03 - 3.84 (m, 4H), 3.49 (q, J = 5.8 Hz, 1H), 3.40 - 3.25 (m, 5H), 2.33 - 2.10 (m, 4H), 2.00 - 1.77 (m, 7H).

Compound ESMS H NMR Compound Structure 1H NMR (300 MHz, : ppm 1.82 — 1.95 (m, 6 H), 2.14 — 2.26 (m, 2 H), 3.31 — 3.35 (m, 4 H), 3.77 — 3.85 (m, 1 H), 638 478.3 3.90 — 3.93 (m, 4 H), 4.71 — 4.80 (m, 3 H), 4.92 (t, J = 6.6 Hz, 2 H), 5.10 (quint., J = 5.6 Hz, 1 H), 6.39 (d, J = 8.9 Hz, 1 H), 6.90 (d, 1H NMR (300 MHz, CDCI3): 1.80 — 1.95 (m, 6 H), 2.10— 2.25 (m, 2 H), 2.52 — 2.64 (m, 4 H), 2.77 (t, J = 5.6 Hz, 2 H), 639 535.3 3.33 (t, J = 4.7 Hz, 4 H), 3.74 (t, J = 4.7 Hz, 4 H), 3.70 — 3.85 (m, 1 H), 3.91 (t, J = 4.7 Hz, 4 H), 4.06 (t, J = 5.6 Hz, 2 H), 4.30 — 1H NMR (300 MHz, CDCI3): ppm 1.40 — 1.50 (m, 2 H), 1.56 — 1.70 (m, 4 H), 1.84— 1.94 (m, 6 H), 2.11 — 2.23 (m, 2 H), 640 533.4 2.46 — 2.58 (m, 4 H), 2.71 — 2.80 (m, 2 H), 3.33 (t, J = 4.7 Hz, 4 H), 3.76 — 3.84 (m, 1 H), 3.91 (t, J = 4.7 Hz, 4 H), 4.07 (t, J = 5.7 H 2014/024767 Compound ESMS H NMR C d St t 1H NMR (400 MHz, CDC|3)6 8.73 — 8.65 (m, 1H), 8.60 (d, J = 1.8 Hz, 1H), 6.93 (d, J = 2.4 Hz, 1H), 6.89 (d, J = 2.3 Hz, 1H), 4.75 (s, 1H), 3.95 — 3.87 (m, 4H), 3.39 — 3.28 (m, 4H), 3.05 — 2.93 (m, 1H), 2.82 — 2.69 (m, 1H), 2.24 — 2.08 (m, 2H), 1.80 — 1.71 (m, 6H), 1.07 (d, J = 6.2 Hz, 6H). 1H NMR (400 MHz, CDCI3) 5 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 7.78 (d, J = 5.8 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 6.36 — 6.26 (m, 1H), 5.99 (d, J = 1.9 Hz, 1H), 4.79 (d, J = 2.4 Hz, 1H), 4.47 (d, J = 7.1 Hz, 1H), 3.99 — 3.85 (m, 4H), 3.56 — 3.49 (m, 1H), 3.39 — 3.26 (m, 4H), 2.28 — 2.16 (m, 2H), 1.98 — 1.80 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J = 1.9 Hz, 1H), 8.57 - 8.45 (m, 1H), 7.81 (d, J = 8.4 Hz, 1H), 7.18 (d, J = 1.2 Hz, 1H), 6.93 (dd, J 643 = 16.8, 2.5 Hz, 2H), 5.48 (s, 1H), 4.83 (dp, J = 4.5, 2.4 Hz, 1H), 4.23 (dp, J = 8.3, 6.6 Hz, 1H), 4.00 - 3.85 (m, 4H), 3.42 - 3.23 (m, 4H), 2.35 - 2.15 (m, 2H), 1.97 - 1.76 (m, 6H), 1.26 (d, J = 6.6 Hz, 6H). 2014/024767 Compound ESMS H NMR 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 6.93 (dd, J = 17.5, 2.5 Hz, 2H), 5.47 (s, 1H), 4.90 (s, 1H), 4.31 (q, J = 7.1 Hz, 2H), 3.92 (dd, J = 5.9, 3.7 Hz, 4H), 3.60 (s, 1H), 3.38 - 3.28 (m, 4H), 2.40 (s, 3H), 2.19 (d, J = 9.4 Hz, 2H), 1.97 - 1.80 (m, 6H), 1.36 (t, J = 7.1 Hz, 3H), 4.83 - 4.76 (m, 1H). 1H NMR (400 MHz, CDCI3) 5 8.68 (d, J = 1.8 Hz, 1H), 8.60 (d, J :19 Hz, 1H), 6.94 (d, J = 2.4 Hz, 1H), 6.87 (d, J = 2.4 Hz, 1H), 4.83 (t, J = 6.9 Hz, 645 2H), 4.76 (s, 1H), 4.45 (t, J = 6.6 Hz, 2H), 4.14 — 4.05 (m, 1H), 3.94 — 3.88 (m, 4H), 3.35 — 3.30 (m, 4H), 2.65 (s, 1H), 2.24 — 2.15 (m, 2H), 1.75 — 1.64 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.71 (d, J = 1.9 Hz, 1H), 8.57 (d, J :19 Hz, 1H), 7.01 - 6.84 (m, 2H), 646 6.18 (d, J = 1.4 Hz, 1H), 4.80 (s, 1H), 4.43 (s, 1H), 3.93 (t, J = 4.9 Hz, 5H), 3.48 (s, 3H), 3.43 - 3.25 (m, 5H), 2.38 - 1.86 (m, 9H).

WO 59690 Compound ESMS H NMR C°mp°”“d St“‘6 ”ret 1H NMR (400 MHz, CDCI3) 5 8.67 (d, J = 1.9 Hz, 1H), 8.59 (d, J = 1.9 Hz, 1H), 6.94 (d, J = 2.5 Hz, 1H), 6.88 (d, J = 2.5 Hz, 1H), 4.75 (s, 1H), 4.03 — 3.94 (m, 2H), 3.94 — 3.83 (m, 4H), 3.41 (td, J = 11.7, 2.1 Hz, 2H), 3.36 — 3.25 (m, 4H), 2.89 — 2.77 (m, 2H), 2.24 — 2.13 (m, 2H), 1.85 — 1.68 (m, 8H), 1.40 (ddd, J = 16.2, 12.3, 4.4 Hz, 3H). 1H NMR (400 MHz, CDCI3) 5 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 7.17 (dd, J = 8.5, 7.4 Hz, 2H), 6.95 (d, J = 2.5 Hz, 1H), 6.90 (d, J = 2.4 648 Hz, 1H), 6.69 (t, J = 7.3 Hz, 1H), 6.63 (d, J = 7.9 Hz, 2H), 4.75 (s, 1H), 3.98 — 3.71 (m, 5H), 3.52 (s, 1H), 3.40 — 3.30 (m, 4H), 2.24 — 2.11 (m, 2H), 1.94 — 1.84 (m, 6H). 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.62 (d, J = 1.9 Hz, 1H), 7.10 (d, J = 2.3 Hz, 1H), 6.99 - 6.81 (m, 2H), 5.52 (d, J = 2.3 Hz, 1H), 4.76 (t, J = .9 Hz, 1H), 4.06 - 3.86 (m, 5H), 3.72 (s, 3H), 3.49 (t, J = .3 Hz, 1H), 3.40 - 3.18 (m, 4H), 2.19 (dq, J = 12.9, 7.1, 6.7 Hz, 2H), 1.90 (dd, J = 9.4, .2 Hz, 7H).

WO 59690 Compound ESMS H NMR 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.62 (d, J :19 Hz, 1H), 8.47 - 8.36 (m, 1H), 6.96 (d, J = 2.5 Hz, 1H), 6.90 650 (d, J = 2.5 Hz, 1H), 6.18 (d, J = 1.2 Hz, 1H), 4.95 - 4.73 (m, 2H), 4.04 - 3.78 (m, 5H), 3.44 - 3.24 (m, 4H), 2.30 - 2.12 (m, 2H), 2.03 - 1.70 (m, 7H), 1.17 - 0.80 (m, 4H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz, 1H), 8.61 (d, J :19 Hz, 1H), 8.50 (d, J =1.1 Hz, 1H), 6.93 (dd, J = 15.9, 2.5 Hz, 2H), 6.17 (d, J =1.1 Hz, 651 1H), 4.98 (d, J = 8.1 Hz, 1H), 4.86 - 4.75 (m, 1H), 3.97 - 3.87 (m, 4H), 3.39 - 3.29 (m, 4H), 2.61 (q, J = 7.6 Hz, 2H), 2.21 (dt, J = 11.2, 5.0 Hz, 2H), 2.04 - 1.82 (m, 6H), 1.25 (t, J = 7.6 Hz, 3H). 1H NMR (300 MHz, Chloroform-d) 6 8.70 (d, J = 1.9 Hz,1H),8.61 (d, J :19 Hz, 1H), 8.52 (d, J =1.1 Hz, 1H), 6.93 (dd, J = 16.0, 2.5 Hz, 2H), 6.19 - 6.12 (m, 1H), 652 4.91 (d, J = 8.0 Hz, 1H), 4.81 (d, J = 5.4 Hz, 1H), 4.13 - 3.77 (m, 5H), 3.40 - 3.29 (m, 4H), 2.80 (hept, J = 6.8 Hz, 1H), 2.27 - 2.00 (m, 2H), 1.99 - 1.83 (m, 6H), 1.40 - 1.12 (m, 6H).

Compound ESMS H NMR “d St“‘6 ”et 1H NMR (300 MHz, Methanol- d4/ CDCI3) 5 8.82 — 8.68 (m, 2H), 8.61 (d, J = 0.8 Hz, 1H), 7.38 (t, J = 0.8 Hz, 1H), 7.18 653 451 .07 (s, 1H), 5.11 —4.99 (m, 1H), 4.47 —4.31 (m, 1H), 3.99 — 3.88 (m, 4H), 3.74 — 3.58 (m, 4H), 2.37 — 2.23 (m, 2H), 2.13 — 1.80 (m, 6H). 1H NMR (300 MHz, CDCI3): ppm 1.82 — 1.95 (m, 6 H), 2.11 — 2.24 (m, 2 H), 2.32 (s, 6 H), 2.68 (t, J = 5.7 Hz, 2 H), 3.29 — 654 493.3 3.37 (m, 4 H), 3.76 — 3.86 (m, 1 H), 3.88 — 3.95 (m, 4 H), 4.00 (t, J = 5.7 Hz, 2 H), 4.29 (d, J = 8.2 Hz, 1 H), 4.70 — 4.83 (m, 1 H) 1H NMR (300 MHz, CDCI3): ppm 1.81 — 1.97 (m, 6 H), 2.10 — 2.25 (m, 2 H), 2.33 (s, 3 H), 2.42 — 2.83 (m, 8 H), 2.78 (t, J 655 548.3 = 5.6 Hz, 2 H), 3.28 — 3.39 (m, 4 H), 3.75 — 3.85 (m, 1 H), 3.86 — 3.97 (m, 4 H), 4.05 (t, J = 5.6 Hz, 2 H), 4.29 (t, J = 8.4 Hz, 1 H) Compound ESMS H NMR “d St“‘6 ”ret 1H NMR (300 MHz, DMSO- d6) 5 8.64 (d, J = 1.9 Hz, 1H), 8.47 (d, J = 1.9 Hz, 1H), 8.25 (d, J = 4.8 Hz, 2H), 7.15 (d, J = 7.3 Hz, 1H), 6.59 — 6.47 (m, 2H), 6.31 (d, J = 2.2 Hz, 1H), .80 — 5.68 (m, 1H), 4.85 (s, 2H), 4.62 (d, J = 5.3 Hz, 0H), 4.24 (t, J = 7.4 Hz, 2H), 3.83 (s, 1H), 3.71 (dd, J = 8.4, 4.7 Hz, 2H), 2.14 — 1.97 (m, 2H), 1.79 (d, J = 19.4 Hz, 5H). 1H NMR (300 MHz, Chloroform-d) 6 8.59 (d, J = 1.9 Hz, 1H), 8.50 (d, J = 1.9 Hz, 1H), 8.11 (s, 2H), 6.91 - 657 6.70 (m, 2H), 4.66 (s, 1H), 3.92 - 3.56 (m, 7H), 3.45 (d, J = 4.3 Hz, 3H), 3.31 - 3.18 (m, 6H), 2.08 (s, 2H), 1.84 (d, J = 38.5 Hz, 8H). 1H NMR (300 MHz, CDCI3): ppm 1.37 (t, J = 7.0 HZ, 3 H), 1.84 — 1.94 (m, 6 H), 2.10— 2.25 (m, 2 H), 3.29 — 3.38 (m, 658 4 H), 3.75 — 3.85 (m, 1 H), 3.88 — 3.95 (m, 4 H), 3.97 (q, J = 7.0 Hz, 2 H), 4.22 — 4.34 (m, 1 H), 4.73-4.80 (m, 1 H), 6.36 (d, J = 9.0 H Compound ESMS C d St t 1H NMR (300 MHz, Chloroform-d) 6 8.69 (d, J = 1.9 Hz, 1H), 8.60 (d, J = 1.9 Hz, 1H), 6.92 (dd, J = 19.6, 659 2.5 Hz, 2H), 5.25 (s, 1H), 4.76 (q, J = 8.3, 7.2 Hz, 2H), 3.97 - 3.87 (m, 4H), 3.58 - 3.28 (m, 8H), 2.40 (s, 3H), 2.24 - 2.13 (m, 2H), 2.07 - 1.78 (m, 6H).

Biological assay ofcompounds ofthe invention DNA-PK tion Assay Compounds were screened for their ability to inhibit DNA—PK kinase using a standard radiometric assay. Briefly, in this kinase assay the transfer of the terminal 33P—phosphate in 33P—ATP to a e substrate is interrogated. The assay was carried out in 384-well plates to a final volume of 50 uL per well containing approximately 6 nM DNA—PK, 50 mM HEPES (pH 7.5), 10 mM MgC12, 25 mM NaCl, 0.01% BSA, 1 mM DTT, 10 ug/mL sheared double-stranded DNA (obtained from Sigma), 0.8 mg/mL DNA- PK peptide ro-Pro-Leu-Ser-Gln-Glu-Ala-Phe-Ala-Asp-Leu-Trp-Lys-Lys- Lys, obtained from an Peptide), and 100 uM ATP. Accordingly, compounds of the invention were dissolved in DMSO to make 10 mM initial stock solutions. Serial dilutions in DMSO were then made to obtain the final ons for the assay. A 0.75 uL aliquot of DMSO or inhibitor in DMSO was added to each well, followed by the addition ofATP substrate solution containing 33P-ATP (obtained from Perkin Elmer). The on was started by the addition of DNA-PK, peptide and ds-DNA. After 45 min, the on was ed with 25 uL of 5% phosphoric acid. The reaction mixture was transferred to MultiScreen HTS 384-well PH plates (obtained from Millipore), allowed to bind for one hour, and washed three times with 1% phosphoric acid. Following the addition of 50 uL of Ultima GoldTM high efficiency scintillant (obtained from Perkin Elmer), the samples were counted in a Packard TopCount NXT Microplate Scintillation and Luminescence Counter (Packard BioScience). The K, values were calculated using Microsoft Excel Solver macros to fit the data to the kinetic model for competitive tight- binding inhibition.

] Each of compounds 1-291, 295—331, 333—367, 369—523, 525-640, 642-644, 646, and 648—659 has a K of less than 1.0 micromolar for the inhibition of DNA-PK.

Each of compounds 3, 6—14, 16—18, 23—34, 36—37, 39—41, 43—46, 49—72, 74—76, 78, 84—101, 103—123, 127—200, 202-291, 295-299, 305, 307-331, 1, 343, 347-366, 4, 376-391, 393-519, 521-523, 526-554, 556-610, 612-640, 642-644, 646, 648-655 and 657- 659 has a K of less than 0.10 micromolar for the inhibition of DNA-PK. gh the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it will be y apparent to those of ry skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto without departing from the spirit or scope of the appended claims.

Claims (68)

1. A compound having the formula: (I), or a pharmaceutically acceptable salt thereof, wherein: Ring A is , , , , or ; Ring B is , , , , , , , , , , or , wherein Ring B is optionally tuted with up to 4 fluorine atoms, up to two OH, or up to two C1-4alkyl which is optionally substituted with up to 3 fluorine atoms, up to two OH, or up to two OC1-2alkyl groups; Ring C is a cyclohexane or a cyclobutane ring; X is –NH-, -O-, or -OC1-4 alkyl-; each of R1 and R2 is, independently, hydrogen, -C(O)NHR4, -C(O)OR4, -NHC(O)R4, -NHC(O)OR4, )NHR4, -NHS(O)2R4, -C0-4 alkyl-NHR4, or -OR4, wherein R1 and R2 cannot simultaneously be hydrogen, and wherein R1 and R2 and the ening carbon atom can form a dioxane or dioxolane ring; R3 is hydrogen, -C1-4alkyl, fluoro, chloro, -OC1-2alkyl, -C(O)H, -C(O)OH, -C(O)OC1-2alkyl, - CN, -C(O)NHC1-2alkyl, or H2, wherein each of said R3 alkyl is ally substituted with up to 3 fluorine atoms, up to two OH, or up to two -OC1-2alkyl groups; R4 is hydrogen, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C3-5cycloalkyl, , a 5membered monocyclic or bicyclic heteroaryl ring selected from pyrrole, imidazole, pyrazole, triazole, thiazole, isothiazole, oxazole, pyridine, pyrimidine, pyrimidinone, pyrazine, pyridazine, and quinoline, or a 4membered monocyclic or bicyclic heterocyclyl ring selected from e, tetrahydrofuran, tetrahydropyran, dihydroisoxazole, pyrimidine- 2,4(1H,3H)-dione, dihydrofuropyrimidine, opyranopyrimidine, dihydropyrrolopyrimidine, tetrahydropteridine, and tetrahydropyridopyrimidine, wherein each of said R4 groups is optionally tuted with up to four Br, Cl, F, or kyl, up to three CN, NO2, kenyl, C2-4alkynyl, C3-6cycloalkyl, C0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-O-C1-4 alkyl, C0-4 alkyl-O-C0-4 alkyl-C3-5 cycloalkyl, C(O)OC1-4 alkyl, C(O)OC0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-C(O)NH2, C(O)NHC1-4 alkyl, C(O)N(C1-4 alkyl)2, C(O)NH(C0-4 alkyl-C3-5 cycloalkyl), CH2OR5, C0-4 alkyl-C(O)R5, C0-4 alkyl-C(O)N(R5)2, C0-4 alkyl-C(O)OR5, C0-4 alkyl-NHC(O)R5, C0-4 alkyl-N(R5)2, a heterocyclic ring system selected from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, pyrrolidine, and piperazine, a heteroaryl ring system selected from furan, oxazole, zole, pyrrole, pyrazole, triazole, oxadiazole, and tetrazole, or up to two OR5, wherein each of said optional R4 substituents is ally substituted with up to four fluorine atoms, up to two C1-4alkyl groups, up to two OH groups, up to two OC1-4alkyl groups, up to two SC1-4alkyl groups, a C(O)C1-4 alkyl, a C(O)OC1-4 alkyl, or a C(O)OC0-4 alkyl-C3-5 cycloalkyl; and each R5 is, independently, hydrogen, C1-4alkyl, a 5membered aryl selected from imidazole, triazole, thiazole, pyridine, and pyrimidine, or a 4membered heterocyclyl selected from e, tetrahydrofuran, and tetrahydropyran, and each R5 group is optionally substituted with chloro, up to three fluorine atoms, up to two C1-2alkyl, CH2OH, CN, up to two OH, up to two OC1-2alkyl, a spirooxetane, pyrrolidine, or triazole, or two R5 groups together with the intervening nitrogen atom form a line ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

2. The nd of claim 1, or a pharmaceutically acceptable salt thereof, wherein Ring C is cyclobutane.

3. The compound of claim 2, having the following formula: (II), or a pharmaceutically acceptable salt thereof.

4. The compound of claim 3, having the ing formula: (II-A), or a pharmaceutically acceptable salt thereof.

5. The compound of claim 4, having the following formula: (II-A-1), or a pharmaceutically acceptable salt thereof.

6. The nd of claim 4 or 5, or a pharmaceutically acceptable salt thereof, wherein R2 is -C0-4 alkyl-NHR4.

7. The compound of claim 3, having the ing formula: (II-B), or a pharmaceutically acceptable salt thereof.

8. The compound of claim 7, having the following formula: (II-B-1), or a pharmaceutically acceptable salt thereof.

9. The compound of claim 7 or 8, or a pharmaceutically acceptable salt thereof, wherein R1 is -C0-4 alkyl-NHR4.

10. The compound of any one of claims 2-9, or a pharmaceutically able salt thereof, wherein X is –O- or -OC1-4 alkyl-.

11. The compound of any one of claims 2-10, or a pharmaceutically acceptable salt thereof, wherein is , , , , or .

12. The compound of claim 11, or a pharmaceutically acceptable salt f, wherein is .

13. The compound of any one of claims 2-12, or a ceutically acceptable salt thereof, wherein R3 is hydrogen.

14. The compound of any one of claims 2-13, or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C3-5cycloalkyl, or phenyl, wherein each of said R4 groups is optionally substituted with up to four Br, Cl, F, or C1-4alkyl, up to three CN, NO2, C2-4alkenyl, C2-4alkynyl, cloalkyl, C0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl- O-C1-4 alkyl, C0-4 alkyl-O-C0-4 alkyl-C3-5 lkyl, 1-4 alkyl, C(O)OC0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-C(O)NH 2, C(O)NHC1-4 alkyl, C(O)N(C1-4 alkyl) 2, C(O)NH(C0-4 alkyl- C3-5 cycloalkyl), CH2OR 5, C 5, C 5) 5, C 0-4 alkyl-C(O)R 0-4 alkyl-C(O)N(R 2, C0-4 alkyl-C(O)OR 0-4 alkyl-NHC(O)R 5, C 5) 0-4 alkyl-N(R 2, a heterocyclic ring system ed from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, dine, pyrrolidine, and piperazine, a heteroaryl ring system ed from furan, oxazole, oxadiazole, e, pyrazole, triazole, oxadiazole, and tetrazole, or up to two OR5, wherein each of said optional R4 substituents is optionally substituted with up to four fluorine atoms, up to two kyl groups, up to two OH groups, up to two OC1-4alkyl groups, up to two SC1- 4alkyl groups, a C(O)C1-4 alkyl, a 1-4 alkyl, or a C(O)OC0-4 alkyl-C3-5 cycloalkyl; and each R5 is, independently, hydrogen, C1-4alkyl, a 5membered heteroaryl selected from imidazole, triazole, thiazole, pyridine, and pyrimidine, or a 4membered heterocyclyl selected from oxetane, tetrahydrofuran, and tetrahydropyran, and each R5 group is optionally substituted with chloro, up to three fluorine atoms, up to two C1-2alkyl, CH2OH, CN, up to two OH, up to two OC1-2alkyl, a spirooxetane, pyrrolidine, or triazole, or two R5 groups together with the ening nitrogen atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

15. The nd of any one of claims 2-13, or a pharmaceutically acceptable salt thereof, wherein R4 is a 5membered monocyclic or bicyclic heteroaryl ring selected from pyrrole, imidazole, pyrazole, triazole, thiazole, isothiazole, oxazole, pyridine, pyrimidine, pyrimidinone, pyrazine, pyridazine, and quinoline, wherein each of said R4 groups is ally substituted with up to four Br, Cl, F, or kyl, up to three CN, NO2, C2- 4alkenyl, C2-4alkynyl, cloalkyl, C0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-O-C1-4 alkyl, C0-4 alkyl-O-C0-4 alkyl-C3-5 cycloalkyl, C(O)OC1-4 alkyl, C(O)OC0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-C(O)NH 2, C(O)NHC1-4 alkyl, C(O)N(C1-4 alkyl) 2, C(O)NH(C0-4 C3-5 cycloalkyl), CH2OR 5, C 5, C 5) 5, 0-4 alkyl-C(O)R 0-4 alkyl-C(O)N(R 2, C0-4 alkyl-C(O)OR C0-4 alkyl-NHC(O)R 5, C 5) 0-4 alkyl-N(R 2, a heterocyclic ring system selected from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, pyrrolidine, and piperazine, a aryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, triazole, oxadiazole, and tetrazole, or up to two OR5, wherein each of said optional R4 substituents is optionally substituted with up to four fluorine atoms, up to two C1-4alkyl groups, up to two OH groups, up to two lkyl groups, up to two SC1- 4alkyl groups, a C(O)C1-4 alkyl, a C(O)OC1-4 alkyl, or a C(O)OC0-4 C3-5 cycloalkyl; and each R5 is, independently, hydrogen, C1-4alkyl, a 5membered heteroaryl selected from imidazole, triazole, thiazole, ne, and pyrimidine, or a 4membered heterocyclyl selected from oxetane, tetrahydrofuran, and tetrahydropyran, and each R5 group is optionally substituted with chloro, up to three ne atoms, up to two C1-2alkyl, CH2OH, CN, up to two OH, up to two OC1-2alkyl, a spirooxetane, pyrrolidine, or triazole, or two R5 groups together with the ening nitrogen atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

16. The compound of any one of claims 2-13, or a pharmaceutically acceptable salt thereof, wherein R4 is a 4membered monocyclic or bicyclic heterocyclyl ring ed from oxetane, tetrahydrofuran, tetrahydropyran, dihydroisoxazole, pyrimidine-2,4(1H,3H)-dione, dihydrofuropyrimidine, dihydropyranopyrimidine, opyrrolopyrimidine, tetrahydropteridine, and tetrahydropyridopyrimidine, wherein each of said R4 groups is optionally substituted with up to four Br, Cl, F, or C1-4alkyl, up to three CN, NO2, C2- 4alkenyl, C2-4alkynyl, C3-6cycloalkyl, C0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-O-C1-4 alkyl, C0-4 alkyl-O-C0-4 alkyl-C3-5 cycloalkyl, 1-4 alkyl, C(O)OC0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-C(O)NH 2, C(O)NHC1-4 alkyl, C(O)N(C1-4 alkyl) 2, C(O)NH(C0-4 C3-5 cycloalkyl), CH2OR 5, C 5, C 5) 5, 0-4 alkyl-C(O)R 0-4 alkyl-C(O)N(R 2, C0-4 alkyl-C(O)OR C0-4 alkyl-NHC(O)R 5, C 5) 0-4 alkyl-N(R 2, a heterocyclic ring system selected from oxetane, ine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, dine, pyrrolidine, and zine, a heteroaryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, triazole, oxadiazole, and tetrazole, or up to two OR5, wherein each of said optional R4 substituents is optionally substituted with up to four fluorine atoms, up to two C1-4alkyl groups, up to two OH , up to two OC1-4alkyl groups, up to two SC1- 4alkyl groups, a C(O)C1-4 alkyl, a C(O)OC1-4 alkyl, or a C(O)OC0-4 alkyl-C3-5 cycloalkyl; and each R5 is, independently, hydrogen, kyl, a 5membered heteroaryl selected from imidazole, triazole, thiazole, pyridine, and pyrimidine, or a 4membered heterocyclyl selected from oxetane, tetrahydrofuran, and tetrahydropyran, and each R5 group is optionally tuted with chloro, up to three fluorine atoms, up to two C1-2alkyl, CH2OH, CN, up to two OH, up to two OC1-2alkyl, a spirooxetane, pyrrolidine, or triazole, or two R5 groups together with the intervening nitrogen atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

17. The compound of claim 1, or a pharmaceutically acceptable salt thereof, n Ring C is cyclohexane.

18. The compound of claim 17, having the following formula: (III), or a pharmaceutically acceptable salt thereof.

19. The compound of claim 17 or 18, or a pharmaceutically acceptable salt thereof, wherein X is –NH-.

20. The compound of any one of claims 17-19, having the following formula: or a ceutically acceptable salt thereof.

21. The compound of claim 20, having the following formula: -1) or (III-A-2), or a ceutically acceptable salt thereof.

22. The nd of claim 20 or 21, or a pharmaceutically acceptable salt thereof, wherein R2 is -C0-4 alkyl-NHR4 or -OR4.

23. The compound of claim 22, or a pharmaceutically acceptable salt thereof, wherein R2 is -NHR4.

24. The compound of claim 22, or a pharmaceutically acceptable salt thereof, wherein R2 is -OR4.

25. The compound of any one of claims 17-19, having the ing formula: (III-B), or a pharmaceutically acceptable salt thereof.

26. The compound of claim 25, having the following formula: (III-B-1) or (III-B-2), or a pharmaceutically acceptable salt thereof.

27. The compound of claim 25 or 26, or a pharmaceutically acceptable salt thereof, wherein R1 is -C0-4 alkyl-NHR4 or -OR4.

28. The compound of claim 27, or a pharmaceutically acceptable salt thereof, wherein R1 is -NHR4.

29. The compound of claim 27, or a pharmaceutically acceptable salt f, wherein R1 is -OR4.

30. The compound of any one of claims 17-29, or a pharmaceutically acceptable salt thereof, wherein is , , , , or .

31. The compound of claim 30, or a pharmaceutically acceptable salt thereof, wherein is .

32. The compound of claim 17 or 18, or a pharmaceutically acceptable salt thereof, n X is –O-.

33. The compound of claim 17, 18 or 32, having the following formula: (III-C), or a pharmaceutically acceptable salt thereof.

34. The compound of claim 33, having the following formula: (III-C-1) or -2), or a pharmaceutically acceptable salt thereof.

35. The compound of claim 33 or 34, or a pharmaceutically acceptable salt thereof, wherein R2 is -C0-4 alkyl-NHR4 or -OR4.

36. The compound of claim 35, or a pharmaceutically acceptable salt thereof, wherein R2 is -NHR4.

37. The compound of claim 35, or a pharmaceutically acceptable salt f, wherein R2 is -OR4.

38. The compound of claim 17, 18 or 32, having the following formula: or a pharmaceutically acceptable salt thereof.

39. The compound of claim 38 having the following formula: (III-D-1) or (III-D-2), or a pharmaceutically acceptable salt thereof.

40. The compound of claim 38 or 39, or a pharmaceutically acceptable salt thereof, wherein R1 is -C0-4 alkyl-NHR4 or -OR4.

41. The compound of claim 40, or a ceutically able salt thereof, wherein R1 is -NHR4.

42. The compound of claim 40, or a ceutically acceptable salt thereof, wherein R1 is -OR4.

43. The compound of claim 38 or 39 having the ing formula: (III-D-3), or a pharmaceutically acceptable salt thereof, wherein Y is –O- or –NH-.

44. The compound of any one of claims 32-43, or a pharmaceutically acceptable salt thereof, wherein is , , , , or .

45. The compound of claim 44, or a pharmaceutically acceptable salt thereof, wherein is .

46. The compound of any one of claims 17-45, or a pharmaceutically acceptable salt thereof, wherein R3 is hydrogen, C1-4alkyl, OC1-2alkyl, C(O)NH2, or C(O)H, wherein each of said R3 alkyl is optionally substituted with OH.

47. The compound of claim 46, or a ceutically acceptable salt thereof, wherein R3 is hydrogen.

48. The compound of any one of claims 17-47, or a pharmaceutically able salt thereof, wherein R4 is hydrogen, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C3-5cycloalkyl, or phenyl, wherein each of said R4 groups is optionally substituted with up to four Br, Cl, F, or C1-4alkyl, up to three CN, NO2, C2-4alkenyl, C2-4alkynyl, C3-6cycloalkyl, C0-4 alkyl-C3-5 lkyl, C0-4 alkyl-O-C1-4 alkyl, C0-4 alkyl-O-C0-4 alkyl-C3-5 cycloalkyl, C(O)OC1-4 alkyl, C(O)OC 0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-C(O)NH 2, C(O)NHC1-4 alkyl, C(O)N(C1-4 alkyl) 2, C(O)NH(C 5, C 5, C 5) 0-4 alkyl-C3-5 cycloalkyl), CH2OR 0-4 alkyl-C(O)R 0-4 C(O)N(R 2, C0-4 alkyl-C(O)OR 5, C 5, C 5) 0-4 alkyl-NHC(O)R 0-4 alkyl-N(R 2, a heterocyclic ring system selected from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, pyrrolidine, and piperazine, a heteroaryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, le, oxadiazole, and tetrazole, or up to two OR5, wherein each of said optional R4 substituents is optionally substituted with up to four fluorine atoms, up to two C1-4alkyl , up to two OH groups, up to two OC1-4alkyl groups, up to two SC1- 4alkyl , a C(O)C1-4 alkyl, a C(O)OC1-4 alkyl, or a C(O)OC0-4 alkyl-C3-5 cycloalkyl; and each R5 is, ndently, hydrogen, C1-4alkyl, a 5membered heteroaryl selected from imidazole, triazole, thiazole, ne, and pyrimidine, or a 4membered cyclyl selected from oxetane, tetrahydrofuran, and tetrahydropyran, and each R5 group is optionally substituted with chloro, up to three fluorine atoms, up to two C1-2alkyl, CH2OH, CN, up to two OH, up to two lkyl, a spirooxetane, pyrrolidine, or triazole, or two R5 groups together with the intervening nitrogen atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

49. The compound of any one of claims 17-47, or a pharmaceutically acceptable salt thereof, wherein R4 is a 5membered monocyclic or bicyclic heteroaryl ring selected from e, imidazole, pyrazole, triazole, thiazole, isothiazole, oxazole, pyridine, pyrimidine, pyrimidinone, pyrazine, pyridazine, and quinoline, wherein each of said R4 groups is optionally substituted with up to four Br, Cl, F, or C1-4alkyl, up to three CN, NO2, C2-4alkenyl, kynyl, C3-6cycloalkyl, C0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-O-C1-4 alkyl, C0-4 alkyl-O-C0-4 alkyl-C3-5 cycloalkyl, C(O)OC1-4 alkyl, 0-4 alkyl-C3-5 cycloalkyl, C0-4 C(O)NH 2, C(O)NHC1-4 alkyl, C(O)N(C1-4 alkyl) 2, (C0-4 C3-5 cycloalkyl), CH2OR 5, C 5, C 5) 5, C 0-4 alkyl-C(O)R 0-4 alkyl-C(O)N(R 2, C0-4 alkyl-C(O)OR 0-4 alkyl-NHC(O)R 5, C 5) 0-4 alkyl-N(R 2, a heterocyclic ring system selected from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, pyrrolidine, and piperazine, a heteroaryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, triazole, oxadiazole, and tetrazole, or up to two OR5, wherein each of said optional R4 substituents is optionally substituted with up to four ne atoms, up to two C1-4alkyl groups, up to two OH groups, up to two OC1-4alkyl , up to two SC1- 4alkyl groups, a C(O)C1-4 alkyl, a C(O)OC1-4 alkyl, or a C(O)OC0-4 alkyl-C3-5 cycloalkyl; and each R5 is, independently, hydrogen, C1-4alkyl, a 5membered heteroaryl selected from imidazole, triazole, thiazole, ne, and pyrimidine, or a 4membered cyclyl selected from oxetane, tetrahydrofuran, and tetrahydropyran, and each R5 group is optionally substituted with chloro, up to three fluorine atoms, up to two C1-2alkyl, CH2OH, CN, up to two OH, up to two OC1-2alkyl, a spirooxetane, pyrrolidine, or triazole, or two R5 groups together with the ening nitrogen atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

50. The compound of claim 49, or a pharmaceutically acceptable salt thereof, wherein R4 is pyridine or pyrimidine, which is optionally substituted with up to four Br, Cl, F, or C1-4alkyl, up to three CN, NO2, C2-4alkenyl, C2-4alkynyl, C3-6cycloalkyl, C0-4 alkyl-C3-5 lkyl, C0-4 alkyl-O-C1-4 alkyl, C0-4 alkyl-O-C0-4 alkyl-C3-5 cycloalkyl, C(O)OC1-4 alkyl, C(O)OC 0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-C(O)NH 2, C(O)NHC1-4 alkyl, C(O)N(C1-4 alkyl) 2, C(O)NH(C 5, C 5, C 5) 0-4 alkyl-C3-5 cycloalkyl), CH2OR 0-4 alkyl-C(O)R 0-4 alkyl-C(O)N(R 2, C0-4 alkyl-C(O)OR 5, C 5, C 5) 0-4 alkyl-NHC(O)R 0-4 alkyl-N(R 2, a heterocyclic ring system ed from oxetane, azetidine, tetrahydrofuran, dihydropyran, ydropyran, morpholine, piperidine, pyrrolidine, and zine, a heteroaryl ring system selected from furan, e, oxadiazole, pyrrole, pyrazole, triazole, oxadiazole, and tetrazole, or up to two OR5, n each of said optional R4 substituents is optionally substituted with up to four fluorine atoms, up to two kyl groups, up to two OH groups, up to two OC1-4alkyl groups, up to two SC1- 4alkyl groups, a C(O)C1-4 alkyl, a C(O)OC1-4 alkyl, or a C(O)OC0-4 C3-5 cycloalkyl; and each R5 is, ndently, hydrogen, C1-4alkyl, a 5membered heteroaryl selected from imidazole, triazole, thiazole, ne, and pyrimidine, or a 4membered heterocyclyl selected from oxetane, tetrahydrofuran, and tetrahydropyran, and each R5 group is optionally substituted with chloro, up to three fluorine atoms, up to two C1-2alkyl, CH2OH, CN, up to two OH, up to two OC1-2alkyl, a spirooxetane, pyrrolidine, or triazole, or two R5 groups together with the intervening en atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

51. The compound of any one of claims 17-47, or a pharmaceutically acceptable salt thereof, wherein R4 is a 4membered monocyclic or bicyclic heterocyclyl ring ed from oxetane, tetrahydrofuran, tetrahydropyran, dihydroisoxazole, pyrimidine-2,4(1H,3H)-dione, dihydrofuropyrimidine, opyranopyrimidine, dihydropyrrolopyrimidine, tetrahydropteridine, and ydropyridopyrimidine, wherein each of said R4 groups is optionally substituted with up to four Br, Cl, F, or kyl, up to three CN, NO2, C2- 4alkenyl, kynyl, cloalkyl, C0-4 C3-5 cycloalkyl, C0-4 alkyl-O-C1-4 alkyl, C0-4 alkyl-O-C0-4 alkyl-C3-5 cycloalkyl, C(O)OC1-4 alkyl, C(O)OC0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-C(O)NH2, C(O)NHC1-4 alkyl, C(O)N(C1-4 alkyl)2, C(O)NH(C0-4 alkyl-C3-5 lkyl), CH2OR5, C0-4 alkyl-C(O)R5, C0-4 alkyl-C(O)N(R5)2, C0-4 alkyl-C(O)OR5, C0-4 alkyl-NHC(O)R5, C0-4 alkyl-N(R5)2, a heterocyclic ring system selected from e, azetidine, ydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, pyrrolidine, and piperazine, a heteroaryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, triazole, oxadiazole, and tetrazole, or up to two OR5, wherein each of said optional R4 substituents is optionally substituted with up to four fluorine atoms, up to two C1-4alkyl groups, up to two OH groups, up to two OC1-4alkyl groups, up to two SC1- 4alkyl groups, a C(O)C1-4 alkyl, a C(O)OC1-4 alkyl, or a C(O)OC0-4 alkyl-C3-5 cycloalkyl; and each R5 is, independently, hydrogen, C1-4alkyl, a 5membered heteroaryl selected from ole, triazole, thiazole, pyridine, and pyrimidine, a 4membered heterocyclyl selected from oxetane, tetrahydrofuran, and tetrahydropyran, and each R5 group is optionally substituted with chloro, up to three fluorine atoms, up to two C1-2alkyl, CH2OH, CN, up to two OH, up to two OC1-2alkyl, a spirooxetane, pyrrolidine, or triazole, or two R5 groups together with the intervening nitrogen atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

52. The compound of claim 32 having the formula: (IV), or a pharmaceutically acceptable salt thereof, wherein R3 is hydrogen, -C1-4alkyl, fluoro, , -OC1-2alkyl, -C(O)NH2, -C(O)H, or -CN, n each of said R3 alkyl is optionally substituted with OH or up to 3 fluorine atoms; R4 is X1 is N, CH, CF, CCl, or CC1-2 alkyl optionally substituted with up to 3 fluorine atoms; X2 is N or CR4c, wherein X1 and X2 cannot simultaneously be N; each of R4a , R4b, and R4c is, independently, hydrogen, F, Cl, Br, CN, NO2, C1-4 alkyl, C0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-O-C1-4 alkyl, C0-4 alkyl-O-C0-4 alkyl-C3-5 cycloalkyl, C2-4 alkenyl, C2-4 alkynyl, C(O)OC1-4 alkyl, C(O)OC0-4 alkyl-C3-5 cycloalkyl, C(O)NH2, C(O)NHC1-4 alkyl, C(O)N(C1-4 alkyl)2, C(O)NH(C0-4 alkyl-C3-5 cycloalkyl), a heterocyclic ring system selected from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, and zine, or a heteroaryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, triazole, and tetrazole, or R4c, R4a, and the ening atoms form a dihydrofuran, a dihydropyran, or a tetrahydropyridine heterocyclic ring system; wherein each of said R4a, R4b, or R4c heterocyclic or heteroaryl ring systems is optionally tuted with up to four fluorine atoms, up to two C1-4 alkyl, up to two OH , a C(O)C1-4 alkyl, a C(O)OC1-4 alkyl, or a C(O)OC0-4 C3-5 cycloalkyl; and wherein each of said R4a, R4b, or R4c alkyl or cycloalkyl is optionally substituted with up to 2 non-geminal OH groups or up to 3 fluorine atoms.

53. The compound of claim 52, or a pharmaceutically acceptable salt thereof, wherein R3 is hydrogen, -C1-4alkyl, alkyl, -C(O)NH2, or -C(O)H, wherein each of said R3 alkyl is optionally substituted with OH.

54. The compound of claim 52 or 53, or a pharmaceutically acceptable salt thereof, wherein R3 is hydrogen.

55. The compound of any one of claims 52-54, or a pharmaceutically acceptable salt thereof, wherein each of X1 and X2 is, independently, CH or N, wherein X1 and X2 cannot simultaneously be N.

56. The nd of any one of claims 52-55, or a ceutically acceptable salt thereof, wherein each of R4a and R4b is, independently, a heterocyclic ring system selected from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, line, piperidine, and piperazine, wherein each of said R4a or R4b heterocyclic ring systems is optionally substituted with up to four fluorine atoms, up to two C1-4 alkyl, up to two OH groups, a -4 alkyl, a C(O)OC 1-4 alkyl, or a C(O)OC0-4 alkyl-C3-5 cycloalkyl; and wherein each of said R4a or R4b alkyl or cycloalkyl is ally substituted with up to 2 nongeminal OH groups or up to 3 fluorine atoms.

57. The compound of any one of claims 52-55, or a pharmaceutically acceptable salt thereof, wherein each of R4a and R4b is, independently, a heteroaryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, triazole, and tetrazole, wherein each of said R4a or R4b heteroaryl ring systems is ally substituted with up to four fluorine atoms, up to two C1-4 alkyl, up to two OH groups, a -4 alkyl, a C(O)OC 1-4 alkyl, or a C(O)OC0-4 alkyl-C3-5 cycloalkyl; and wherein each of said R4a or R4b alkyl or cycloalkyl is optionally substituted with up to 2 nongeminal OH groups or up to 3 fluorine atoms.

58. The compound of any one of claims 52-55, or a pharmaceutically acceptable salt thereof, wherein each of R4a and R4b is, independently, en, F, Cl, Br, CN, NO2, C1-4 alkyl, C0-4 alkyl-C3-5 cycloalkyl, C0-4 alkyl-O-C1-4 alkyl, C0-4 alkyl-O-C0-4 alkyl-C3-5 cycloalkyl, C2-4 alkenyl, C2-4 alkynyl, 1-4 alkyl, C(O)OC0-4 alkyl-C3-5 cycloalkyl, C(O)NH2, C(O)NHC 1-4 alkyl, C(O)N(C1-4 alkyl) 2, or C(O)NH(C0-4 alkyl-C3-5 cycloalkyl), wherein each of said R4a or R4b alkyl or cycloalkyl is optionally substituted with up to 2 nongeminal OH groups or up to 3 fluorine atoms.

59. A compound, or a pharmaceutically able salt thereof, selected from HN N N i U O H 0* w a \NH O ONH /|\ N\|/ NE\I/ c/H3 o W HN IN N H HN 01 OUA O 0NH /|\N] NE\|/ IN mHL s HN W H3 O IN coGig o 0 H3 N OHAO n0 /|\N] /|\ N\|/ HN N W HN IN H 0w OUA NH 0 0NH /|\ N\|/ HN N N o 0 HN 03/ H3leC Hw OX NH H 0 ea NH /|\ N\|/ NE \I/ HN IN N O HN H 0 my A0 NH H3c O /|\N10 HANH c N/|\ 279 279 N N H3C N N N N N O O O N O N N N N N N N O OH N O N N N N N N N O N HN N N O N N N O HN 284 284 O N N N HN O O N CN N O N N N 288 288 289 289 290 290 O N O N O N N N O O O N 293 293 O N O N N N N OHO 296 296 297 297 298 298 O N N O O N F N N O 300 300 O N N N O N O N CH3 O O N O N F N S N O O N N S O O N H3C O N O O N N N O N N F N O N N Cl O

60. A compound, or a pharmaceutically acceptable salt f, selected from N N \ u. K / fl C\I, ‘o NH /1,:vI /r 3 308 308 309 309 N\(“O O NH 310 310 318 318 320 320 338 338 C] i] «an: «Q 340 340 HHHHH 343 343 346 346 347 347 348 348 349 349 350 350 351 351 m v o Ann "j" HN aN kIN W /|\ N\|/o «M! rw o In U NU H NH \ ENjo EN\|/o H. e rN v IN \I¢ xa mU "(Mo \INa /|\ N\I/o CoJ/qul/N- o k CTu UO N NAIVN| /|\ \I/ o m 352 352 and .

61. A compound of the formula: O N O N N N O N O N H CH3 , N CH3 O , , , , , , or , or a ceutically acceptable salt thereof.

62. A compound of the formula: , or a pharmaceutically acceptable salt thereof.

63. A pharmaceutical composition comprising a compound of any one of claims 1-62, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

64. Use of a compound of any one of claims 1-62, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of claim 63, in the cture of a medicament for sensitizing a breast , colorectal cancer, gastroesophageal cancer, head and neck cancer, melanoma, lung cancer, pancreatic cancer or te cancer cell to a chemotherapeutic agent.

65. Use of a compound of any one of claims 1-62, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of claim 63, in the manufacture of a medicament for iating radiotherapy or a chemotherapeutic agent for the treatment of breast cancer, colorectal cancer, gastroesophageal cancer, head and neck cancer, ma, lung cancer, pancreatic cancer or te cancer in a patient.

66. Use of a compound of any one of claims 1-62, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of claim 63, in the manufacture of a medicament for treating breast cancer, colorectal , gastroesophageal cancer, head and neck cancer, melanoma, lung cancer, pancreatic cancer, or prostate cancer in a patient.

67. Use of a compound of any one of claims 1-62, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of claim 63, in the manufacture of a ment for inhibiting breast cancer, colorectal cancer, gastroesophageal cancer, head and neck cancer, melanoma, lung cancer, pancreatic cancer, or prostate cancer cell growth in a patient.

68. A compound as claimed in any one of claims 1, 61 or 62, substantially as herein bed with reference to any one of the Examples thereof.