NZ706249A - Stable injectable pharmaceutical composition of epinephrine or salts thereof - Google Patents
Stable injectable pharmaceutical composition of epinephrine or salts thereofInfo
- Publication number
- NZ706249A NZ706249A NZ706249A NZ70624913A NZ706249A NZ 706249 A NZ706249 A NZ 706249A NZ 706249 A NZ706249 A NZ 706249A NZ 70624913 A NZ70624913 A NZ 70624913A NZ 706249 A NZ706249 A NZ 706249A
- Authority
- NZ
- New Zealand
- Prior art keywords
- epinephrine
- sodium metabisulfite
- salts
- pharmaceutical composition
- injectable pharmaceutical
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention refers to a stabilized injectable pharmaceutical composition of epinephrine or salts thereof comprising sodium metabisulfite, wherein the ratio of the amount of epinephrine or salt thereof to sodium metabisulfite in the composition ranges from about 1 :0.005 to about 1:1.5 by weight. It has been observed that stable injectable epinephrine compositions with excellent storage stability and substantially free of overages can be prepared using sodium metabisulfite in said ratios. Particularly, it was found that using sodium metabisulfite in said ratios controls levels of adrenaline sulfonate impurity in said pharmaceutical compositions.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2934MU2012 | 2012-10-08 | ||
PCT/IB2013/053520 WO2014057365A1 (en) | 2012-10-08 | 2013-05-03 | Stable injectable pharmaceutical composition of epinephrine or salts thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ706249A true NZ706249A (en) | 2016-06-24 |
Family
ID=54261202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ706249A NZ706249A (en) | 2012-10-08 | 2013-05-03 | Stable injectable pharmaceutical composition of epinephrine or salts thereof |
Country Status (4)
Country | Link |
---|---|
BR (1) | BR112015007404A2 (en) |
MX (1) | MX2015004201A (en) |
NZ (1) | NZ706249A (en) |
RU (1) | RU2015117254A (en) |
-
2013
- 2013-05-03 BR BR112015007404A patent/BR112015007404A2/en not_active IP Right Cessation
- 2013-05-03 RU RU2015117254A patent/RU2015117254A/en not_active Application Discontinuation
- 2013-05-03 NZ NZ706249A patent/NZ706249A/en not_active IP Right Cessation
- 2013-05-03 MX MX2015004201A patent/MX2015004201A/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112015007404A2 (en) | 2017-07-04 |
RU2015117254A (en) | 2016-11-27 |
MX2015004201A (en) | 2015-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PSEA | Patent sealed | ||
LAPS | Patent lapsed |