NZ706249A - Stable injectable pharmaceutical composition of epinephrine or salts thereof - Google Patents

Stable injectable pharmaceutical composition of epinephrine or salts thereof

Info

Publication number
NZ706249A
NZ706249A NZ706249A NZ70624913A NZ706249A NZ 706249 A NZ706249 A NZ 706249A NZ 706249 A NZ706249 A NZ 706249A NZ 70624913 A NZ70624913 A NZ 70624913A NZ 706249 A NZ706249 A NZ 706249A
Authority
NZ
New Zealand
Prior art keywords
epinephrine
sodium metabisulfite
salts
pharmaceutical composition
injectable pharmaceutical
Prior art date
Application number
NZ706249A
Inventor
Girish Kumar Jain
Amit Gupta
Rajendra Nandlal Nagori
Arvind Yekanathsa Merwade
Keshav Deo
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Priority claimed from PCT/IB2013/053520 external-priority patent/WO2014057365A1/en
Publication of NZ706249A publication Critical patent/NZ706249A/en

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention refers to a stabilized injectable pharmaceutical composition of epinephrine or salts thereof comprising sodium metabisulfite, wherein the ratio of the amount of epinephrine or salt thereof to sodium metabisulfite in the composition ranges from about 1 :0.005 to about 1:1.5 by weight. It has been observed that stable injectable epinephrine compositions with excellent storage stability and substantially free of overages can be prepared using sodium metabisulfite in said ratios. Particularly, it was found that using sodium metabisulfite in said ratios controls levels of adrenaline sulfonate impurity in said pharmaceutical compositions.
NZ706249A 2012-10-08 2013-05-03 Stable injectable pharmaceutical composition of epinephrine or salts thereof NZ706249A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2934MU2012 2012-10-08
PCT/IB2013/053520 WO2014057365A1 (en) 2012-10-08 2013-05-03 Stable injectable pharmaceutical composition of epinephrine or salts thereof

Publications (1)

Publication Number Publication Date
NZ706249A true NZ706249A (en) 2016-06-24

Family

ID=54261202

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ706249A NZ706249A (en) 2012-10-08 2013-05-03 Stable injectable pharmaceutical composition of epinephrine or salts thereof

Country Status (4)

Country Link
BR (1) BR112015007404A2 (en)
MX (1) MX2015004201A (en)
NZ (1) NZ706249A (en)
RU (1) RU2015117254A (en)

Also Published As

Publication number Publication date
BR112015007404A2 (en) 2017-07-04
RU2015117254A (en) 2016-11-27
MX2015004201A (en) 2015-06-10

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Legal Events

Date Code Title Description
PSEA Patent sealed
LAPS Patent lapsed