NZ703512A - Macrocyclic compounds as trk kinase inhibitors - Google Patents

Macrocyclic compounds as trk kinase inhibitors

Info

Publication number
NZ703512A
NZ703512A NZ703512A NZ70351211A NZ703512A NZ 703512 A NZ703512 A NZ 703512A NZ 703512 A NZ703512 A NZ 703512A NZ 70351211 A NZ70351211 A NZ 70351211A NZ 703512 A NZ703512 A NZ 703512A
Authority
NZ
New Zealand
Prior art keywords
compounds
formula
kinase inhibitors
macrocyclic compounds
hexaazapentacyclo
Prior art date
Application number
NZ703512A
Inventor
Steven Wade Andrews
Kevin Ronald Condroski
Julia Haas
Yutong Jiang
Gabrielle R Kolakowski
Jeongbeob Seo
Hong-Woon Yang
Qian Zhao
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Priority claimed from NZ604708A external-priority patent/NZ604708A/en
Publication of NZ703512A publication Critical patent/NZ703512A/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Disclosed herein are macrocyclic hexaazapentacyclo-pentacosa-heptaen-one compounds of formula (I), wherein the variables ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined in the specification. These compounds exhibit Trk family protein tyrosine kinase inhibition and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases. Also disclosed is a process for the preparation of the compounds of formula I. Specific examples of the compounds of formula I include (6R)-9-fluoro-2,11,15,19,20,23-hexaazapentacyclo[15.5.2.17,11.02,6.020,24]pentacosa-1(23),7,9,17(24),18,21-hexaene-16,25-dione and (4R,6R,15R)-9-fluoro-4,15-dihydroxy-13-oxa-2,17,21,22,25-pentaazapentacyclo[17.5.2.02,6.07,12.022,26]hexacosa-1(25),7(12),8,10,19(26),20,23-heptaen-18-one.
NZ703512A 2010-05-20 2011-05-13 Macrocyclic compounds as trk kinase inhibitors NZ703512A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34676710P 2010-05-20 2010-05-20
US201061426716P 2010-12-23 2010-12-23
NZ604708A NZ604708A (en) 2010-05-20 2011-05-13 Macrocyclic compounds as trk kinase inhibitors

Publications (1)

Publication Number Publication Date
NZ703512A true NZ703512A (en) 2016-08-26

Family

ID=55700963

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ703512A NZ703512A (en) 2010-05-20 2011-05-13 Macrocyclic compounds as trk kinase inhibitors

Country Status (4)

Country Link
ME (1) ME02808B (en)
NZ (1) NZ703512A (en)
RS (1) RS56275B1 (en)
UA (1) UA110701C2 (en)

Also Published As

Publication number Publication date
RS56275B1 (en) 2017-11-30
ME02808B (en) 2018-01-20
UA110701C2 (en) 2016-02-10

Similar Documents

Publication Publication Date Title
NZ604708A (en) Macrocyclic compounds as trk kinase inhibitors
GEP201606560B (en) Macrocyclic derivatives for the treatment of proliferative diseases
MX2009012168A (en) Pyrrolopyridine derivatives and their use as bace inhibitors.
MX2011011335A (en) Inhibitors of pi3 kinase and / or mtor.
CA2893804C (en) New bicyclic compounds and their use as antibacterial agents and .beta.-lactamase inhibitors
NZ590334A (en) ICOTINIB HYDROCHLORIDE (4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crownquinazoline hydrochloride), SYNTHESIS, CRYSTALLOGRAPHIC FORM, MEDICAL COMBINATION, AND USES THEREOF
GEP20166484B (en) Protein kinase inhibitors
GEP20156285B (en) Compounds and compositions as trk inhibitors
MX2011009796A (en) Inhibitors of pi3 kinase.
NZ600430A (en) Spiro-oxindole mdm2 antagonists
WO2011117145A3 (en) Pyrrolopyrazine kinase inhibitors
MX348974B (en) 1,6- diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections.
UA109459C2 (en) 5,6-Dihydroimidazo derivatives [1,2-a] Pyrazine-8-ylamine, Suitable as BACE-SECRETASE INHIBITORS (BACE)
MX358682B (en) Pyrazolo [1, 5a] pyrimidine and thieno [3, 2b] pyrimidine derivatives as irak4 modulators.
NZ708928A (en) Mannose derivatives for treating bacterial infections
GEP20227434B (en) 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-one derivatives as hpk1 inhibitors for the treatment of cancer
JO2848B1 (en) Organic Compounds
SG170101A1 (en) 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial.
PL2250172T3 (en) Pyrrolopyrazine kinase inhibitors
TW200942543A (en) Pyrrolopyrazine kinase inhibitors
MX2009000333A (en) Pyrrolopyrimidines for pharmaceutical compositions.
MX2009010059A (en) Quinoline derivatives for the treatment of inflammatory diseases.
UA109687C2 (en) 3,4-DIHYDROPYRROLO$1,2-a]PYRAZINE-1-YLAMINE DERIVATIVES USEFUL AS BETA-SECRETASE (BACE) INHIBITORS
AU2012204982A8 (en) 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors
MY150747A (en) Pyrido[2,3-d] pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer

Legal Events

Date Code Title Description
ERR Error or correction

Free format text: THE FILED DATE HAS BEEN CORRECTED TO 13/05/2011

Effective date: 20150123

PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 13 MAY 2018 BY PIZZEYS PATENT AND TRADE MARK ATTORNEYS PTY LTD

Effective date: 20170307

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 13 MAY 2019 BY COMPUTER PACKAGES INC

Effective date: 20180501

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 13 MAY 2020 BY COMPUTER PACKAGES INC

Effective date: 20190418

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 13 MAY 2021 BY CPA GLOBAL

Effective date: 20200326

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 13 MAY 2022 BY CPA GLOBAL

Effective date: 20210401

LAPS Patent lapsed