NZ631001A - Solid phase peptide synthesis of insulin using side chain anchored lysine - Google Patents

Solid phase peptide synthesis of insulin using side chain anchored lysine

Info

Publication number
NZ631001A
NZ631001A NZ631001A NZ63100113A NZ631001A NZ 631001 A NZ631001 A NZ 631001A NZ 631001 A NZ631001 A NZ 631001A NZ 63100113 A NZ63100113 A NZ 63100113A NZ 631001 A NZ631001 A NZ 631001A
Authority
NZ
New Zealand
Prior art keywords
lysine
insulin
chain
protected
side chain
Prior art date
Application number
NZ631001A
Inventor
Kleomenis K Barlos
Dimitrios Gatos
Konstantinos Barlos
Efstathios Liopyris
Michail Ziovas
Original Assignee
Chemical & Biopharmaceutical Laboratories Of Patras S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemical & Biopharmaceutical Laboratories Of Patras S A filed Critical Chemical & Biopharmaceutical Laboratories Of Patras S A
Publication of NZ631001A publication Critical patent/NZ631001A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Disclosed herein is a method for the solid phase synthesis of a protected, partially protected or unprotected peptides including insulin B-chain or an insulin B-chain derivative, wherein the process comprising: preparing a lysine-resin conjugate comprising a resin and a lysine or a lysine derivative of the formula shown herein; and coupling the lysine-resin conjugate of said formula, wherein R is selected from – OH, a carboxyl protecting group and a peptide residue comprising 1 to 200 amino acids comprising optionally protected side chain and optionally protected terminal carboxyl group, with a protected, partially protected or unprotected peptide residue Ib, where the peptide residue comprising 1 to 200 amino acids and the peptide residue Ib together comprises the insulin B-chain or the insulin B-chain derivative, to form the protected, partially protected or unprotected insulin B-chain or an insulin B-chain derivative. The lysine and lysine containing peptides are attached through the lysine side chain on acid and thermo liable resins.
NZ631001A 2012-04-20 2013-04-19 Solid phase peptide synthesis of insulin using side chain anchored lysine NZ631001A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261636193P 2012-04-20 2012-04-20
PCT/IB2013/053111 WO2013156977A1 (en) 2012-04-20 2013-04-19 Solid phase peptide synthesis of insulin using side chain anchored lysine

Publications (1)

Publication Number Publication Date
NZ631001A true NZ631001A (en) 2017-05-26

Family

ID=48539334

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ631001A NZ631001A (en) 2012-04-20 2013-04-19 Solid phase peptide synthesis of insulin using side chain anchored lysine

Country Status (10)

Country Link
US (2) US20160031962A1 (en)
EP (1) EP2838915B1 (en)
CN (1) CN104428314B (en)
BR (1) BR112014026077B1 (en)
CA (1) CA2870891C (en)
HK (1) HK1203525A1 (en)
IL (1) IL235183B (en)
IN (1) IN2014DN09089A (en)
NZ (1) NZ631001A (en)
WO (1) WO2013156977A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106432472B (en) * 2016-10-24 2020-01-03 合肥国肽生物科技有限公司 Solid-phase synthesis method of insulin
US20190315806A1 (en) 2016-12-16 2019-10-17 Institute Of Medicinal Biotechnology, Chinese Academy Of Medical Sciences Polymyxin derivative, preparation method and application thereof
KR20210005630A (en) * 2018-04-16 2021-01-14 유니버시티 오브 유타 리서치 파운데이션 Glucose-reactive insulin
CN111518009B (en) * 2019-02-01 2023-06-23 鲁南制药集团股份有限公司 Fatty acid derivative and synthesis method thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562942B1 (en) * 1999-02-23 2003-05-13 Neurocrine Biosciences, Inc. Methods for treatment of diabetes using peptide analogues of insulin
WO2004052916A2 (en) * 2002-12-06 2004-06-24 Adaptive Therapeutics, Inc. Novel cyclic peptides comprising cis-3 aminocycloalkanecarboxylic acids
BRPI0413276B8 (en) * 2003-08-05 2021-05-25 Novo Nordisk As insulin derivative, zinc complex thereof, and pharmaceutical composition
WO2006082204A1 (en) * 2005-02-02 2006-08-10 Novo Nordisk A/S Insulin derivatives
CA2665559A1 (en) * 2006-10-05 2008-04-10 Lonza Ag Method for peptide synthesis
WO2008109079A2 (en) * 2007-03-01 2008-09-12 Novetide, Ltd. High purity peptides
WO2010125079A2 (en) * 2009-05-01 2010-11-04 F. Hoffmann-La Roche Ag Insulinotropic peptide synthesis using solid and solution phase combination techniques
GR1007010B (en) * 2009-10-08 2010-10-07 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), INSULINOID Peptides

Also Published As

Publication number Publication date
BR112014026077A2 (en) 2017-06-27
EP2838915A1 (en) 2015-02-25
CN104428314B (en) 2021-11-02
HK1203525A1 (en) 2015-10-30
BR112014026077B1 (en) 2022-03-08
US20210388051A1 (en) 2021-12-16
CA2870891A1 (en) 2013-10-24
CN104428314A (en) 2015-03-18
EP2838915B1 (en) 2018-05-30
CA2870891C (en) 2022-04-05
AU2013250755A1 (en) 2014-11-06
IL235183B (en) 2018-01-31
WO2013156977A1 (en) 2013-10-24
IN2014DN09089A (en) 2015-05-22
US20160031962A1 (en) 2016-02-04

Similar Documents

Publication Publication Date Title
WO2009087082A3 (en) Novel insulin derivatives having an extremely delayed time-action profile
WO2013098802A3 (en) Solid phase peptide synthesis via side chain attachment of hydroxyl amino acids
WO2006119388A8 (en) Methods for the production of peptide having a c-terminal amide
NZ631001A (en) Solid phase peptide synthesis of insulin using side chain anchored lysine
WO2009087081A3 (en) Novel insulin derivatives having an extremely delayed time-action profile
WO2011159895A3 (en) Single chain insulin agonists exhibiting high activity at the insulin receptor
UA103015C2 (en) Novel insulin derivatives having an extremely delayed time-action profile
WO2014052647A3 (en) Proline-locked stapled peptides and uses thereof
NZ618391A (en) Antigenic tau peptides and uses thereof
IN2014DN03424A (en)
WO2013108044A3 (en) Norbornene modified peptides and their labelling ith tetrazine compounds
HRP20220455T1 (en) Modified amino acids comprising an azido group
WO2008133164A1 (en) Immobilized protein immobilized only at its amino terminal in orientation-controlled manner
WO2010138736A3 (en) A method to produce a highly concentrated immunoglobulin preparation for subcutaneous use
BRPI0718996B8 (en) method for preparing a peptide of the formula hd-?-nal-[cys-tyr-d-trp-lys-val-cys]-thr-nh2 or hd-?-nal-cys(acm)-tyr-d- trp-lys-val-cys(acm)-thr
NZ628756A (en) Immunogens for hiv vaccination
NZ612161A (en) Radiolabled her2 binding peptides
EP1992639A4 (en) Peptide vaccine for inducing production of anti-amyloid- -peptide antibody
NZ590872A (en) Process for the preparation of polypeptide glatiramer acetate
WO2012051498A3 (en) Antibodies that bind amyloid oligomers
WO2012008785A3 (en) Method for preparing ramalin
MX2014015876A (en) Cell penetrating peptides to target eif4e.
WO2012023033A3 (en) Mch-i restricted epitopes containing non-natural amino acid residues
WO2008066816A3 (en) Derivatization or ligaton of peptides
NZ586074A (en) LCLRP peptides, constructs and uses thereof

Legal Events

Date Code Title Description
ASS Change of ownership

Owner name: CHEMICAL + BIOPHARMACEUTICAL LABORATORIES OF P, GR

Effective date: 20170330

ERR Error or correction

Free format text: THE INVENTOR HAS BEEN CORRECTED TO 3156634, BARLOS, KLEOMENIS K., C/O CHEMICAL + BIOPHARMACEUTICALLABORATORIES OF PATRAS S.A.INDUSTRIAL AREA OF PATRASBUILDING SQUARE 1ACHAEAGR-26000 PATRAS, GR; 3556072, GATOS, DIMITRIOS, EGNATIAS 3, PATRAS GR-26223, GR; 3556078, ZIOVAS, MICHAIL, IONNI POLEMI KAI MELISSINOY 1, PATRAS GR-26442, GR; 3556080, BARLOS, KONSTANTINOS, DIM. IPSILANTOU 3A, PATRAS GR-26222, GR; 3556082, LIOPYRIS, EFSTATHIOS, TRIKALON 11, PATRAS GR-26333, GR

Effective date: 20170224

Free format text: THE OWNER HAS BEEN CORRECTED TO 3156636, BARLOS, KLEOMENIS K., C/O CHEMICAL + BIOPHARMACEUTICAL, LABORATORIES OF PATRAS S.A., INDUSTRIAL AREA OF PATRAS, BUILDING SQUARE 1, ACHAEA GR-26000 PATRAS, GR; 3556072, GATOS, DIMITRIOS, EGNATIAS 3, PATRAS GR-26223, GR; 3556078, ZIOVAS, MICHAIL, IONNI POLEMI KAI MELISSINOY 1, PATRAS GR-26442, GR; 3556080, BARLOS, KONSTANTINOS, DIM. IPSILANTOU 3A, PATRAS GR-26222, GR; 3556082, LIOPYRIS, EFSTATHIOS, TRIKALON 11, PATRAS GR-26333, GR

Effective date: 20170224

PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 19 APR 2020 BY BALDWINS INTELLECTUAL PROPERTY

Effective date: 20170903

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 19 APR 2021 BY ENVOY

Effective date: 20200414

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 19 APR 2022 BY RENEWALS TEAM

Effective date: 20210415

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 19 APR 2023 BY ENVOY

Effective date: 20220415

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 19 APR 2024 BY ENVOY

Effective date: 20230411