NZ629387A - Monoclonal antibodies against amyloid beta protein and uses thereof - Google Patents

Monoclonal antibodies against amyloid beta protein and uses thereof

Info

Publication number
NZ629387A
NZ629387A NZ629387A NZ62938706A NZ629387A NZ 629387 A NZ629387 A NZ 629387A NZ 629387 A NZ629387 A NZ 629387A NZ 62938706 A NZ62938706 A NZ 62938706A NZ 629387 A NZ629387 A NZ 629387A
Authority
NZ
New Zealand
Prior art keywords
seq
amyloid beta
beta protein
monoclonal antibodies
antibodies against
Prior art date
Application number
NZ629387A
Inventor
Boris Labkovsky
Andreas R Striebinger
Heinz Hillen
Ulrich Ebert
Stefan Barghorn
Patrick Keller
Original Assignee
Abbvie Inc
Abbvie Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc, Abbvie Deutschland filed Critical Abbvie Inc
Priority claimed from NZ609196A external-priority patent/NZ609196A/en
Publication of NZ629387A publication Critical patent/NZ629387A/en

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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Disclosed is a monoclonal antibody comprising a variable heavy chain and a variable light chain, wherein the three CDRs of the variable heavy chain comprise the amino acid sequences of SEQ ID NO: 13 (SYGMS), SEQ ID NO: 14 (SIKNNGGSTYYPDSLKG), and SEQ ID NO: 15 (SGDY), and the three CDRs of the variable light chain comprise the amino acid sequences of SEQ ID NO: 16 (RSSQSLVHSNGDTFLH), SEQ ID NO: 17 (KVSNRFS) and SEQ ID NO: 18 (SQSIHVPWT), wherein the antibody binds with greater specificity to an amyloid beta protein globulomer than to an amyloid beta protein monomer. Also disclosed is the use of said antibody in the use of treating or preventing Alzheimer’s disease.
NZ629387A 2005-11-30 2006-11-30 Monoclonal antibodies against amyloid beta protein and uses thereof NZ629387A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74086605P 2005-11-30 2005-11-30
US77895006P 2006-03-03 2006-03-03
NZ609196A NZ609196A (en) 2005-11-30 2006-11-30 Monoclonal antibodies against amyloid beta protein and uses thereof

Publications (1)

Publication Number Publication Date
NZ629387A true NZ629387A (en) 2016-01-29

Family

ID=50779222

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ629387A NZ629387A (en) 2005-11-30 2006-11-30 Monoclonal antibodies against amyloid beta protein and uses thereof

Country Status (7)

Country Link
CN (2) CN105924521A (en)
CA (1) CA2918092C (en)
DK (1) DK2289909T3 (en)
ME (1) ME01826B (en)
NZ (1) NZ629387A (en)
SI (3) SI2289909T1 (en)
UA (1) UA95933C2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021000235A (en) * 2018-07-17 2021-03-25 Jiangsu Hengrui Medicine Co Anti-abeta antibody, antigen-binding fragment thereof and application thereof.
CN109374902A (en) * 2018-10-08 2019-02-22 杭州康知生物科技有限公司 A kind of latex enhancing Immunoturbidimetric kit of quantitative detection IgG4 and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7964192B1 (en) * 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
EP1078005B1 (en) * 1998-05-21 2010-04-21 University Of Tennessee Research Foundation Methods for amyloid removal using anti-amyloid antibodies
UA81216C2 (en) * 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
DE10303974A1 (en) * 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid β (1-42) oligomers, process for their preparation and their use

Also Published As

Publication number Publication date
CN106008712A (en) 2016-10-12
SI2289909T1 (en) 2015-03-31
SI1976877T1 (en) 2014-05-30
CN105924521A (en) 2016-09-07
CA2918092A1 (en) 2007-06-07
SI1954718T1 (en) 2015-01-30
CA2918092C (en) 2020-07-14
UA95933C2 (en) 2011-09-26
ME01826B (en) 2014-12-20
DK2289909T3 (en) 2015-02-02

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