NZ624622A - Manufacturing process for pyrimidine derivatives - Google Patents

Manufacturing process for pyrimidine derivatives

Info

Publication number
NZ624622A
NZ624622A NZ624622A NZ62462211A NZ624622A NZ 624622 A NZ624622 A NZ 624622A NZ 624622 A NZ624622 A NZ 624622A NZ 62462211 A NZ62462211 A NZ 62462211A NZ 624622 A NZ624622 A NZ 624622A
Authority
NZ
New Zealand
Prior art keywords
compound
manufacturing process
pyrimidine derivatives
formula
disclosure
Prior art date
Application number
NZ624622A
Inventor
John Vincent Calienni
La Cruz Marilyn De
Dietmar Flubacher
Baoqing Gong
Prasad Koteswara Kapa
Piotr H Karpinski
Hui Liu
Pascal Michel
Rasmus Mose
Maria Caterina Testa
Liladhar Murlidhar Waykole
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Priority claimed from NZ608285A external-priority patent/NZ608285A/en
Publication of NZ624622A publication Critical patent/NZ624622A/en

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Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

This disclosure relates to processes for manufacturing a compound of formula (5) or a stereoisomer, tautomer or a salt thereof using the intermediate 6-acetamido-4-(trifluoromethyl)pyridine-3-ylboronic acid. In the compound, W can be a substituted carbon or a nitrogen and R1 to R4 can have various substitutions as described in the specification. Compounds of formula (5), with a morpholine and pyrimidine moieties, are PI3K inhibitors. The disclosure also relates to the specific compound 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine (Buparlisib).
NZ624622A 2010-10-01 2011-09-29 Manufacturing process for pyrimidine derivatives NZ624622A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38872110P 2010-10-01 2010-10-01
US201161494915P 2011-06-09 2011-06-09
NZ608285A NZ608285A (en) 2010-10-01 2011-09-29 Manufacturing process for pyrimidine derivatives

Publications (1)

Publication Number Publication Date
NZ624622A true NZ624622A (en) 2014-10-31

Family

ID=51796566

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ624621A NZ624621A (en) 2010-10-01 2011-09-29 Manufacturing process for pyrimidine derivatives
NZ624622A NZ624622A (en) 2010-10-01 2011-09-29 Manufacturing process for pyrimidine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NZ624621A NZ624621A (en) 2010-10-01 2011-09-29 Manufacturing process for pyrimidine derivatives

Country Status (1)

Country Link
NZ (2) NZ624621A (en)

Also Published As

Publication number Publication date
NZ624621A (en) 2014-12-24

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Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 29 SEP 2016 BY CPA GLOBAL

Effective date: 20150815

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 29 SEP 2017 BY CPA GLOBAL

Effective date: 20160819

LAPS Patent lapsed