NZ624622A - Manufacturing process for pyrimidine derivatives - Google Patents
Manufacturing process for pyrimidine derivativesInfo
- Publication number
- NZ624622A NZ624622A NZ624622A NZ62462211A NZ624622A NZ 624622 A NZ624622 A NZ 624622A NZ 624622 A NZ624622 A NZ 624622A NZ 62462211 A NZ62462211 A NZ 62462211A NZ 624622 A NZ624622 A NZ 624622A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- manufacturing process
- pyrimidine derivatives
- formula
- disclosure
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
This disclosure relates to processes for manufacturing a compound of formula (5) or a stereoisomer, tautomer or a salt thereof using the intermediate 6-acetamido-4-(trifluoromethyl)pyridine-3-ylboronic acid. In the compound, W can be a substituted carbon or a nitrogen and R1 to R4 can have various substitutions as described in the specification. Compounds of formula (5), with a morpholine and pyrimidine moieties, are PI3K inhibitors. The disclosure also relates to the specific compound 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine (Buparlisib).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38872110P | 2010-10-01 | 2010-10-01 | |
US201161494915P | 2011-06-09 | 2011-06-09 | |
NZ608285A NZ608285A (en) | 2010-10-01 | 2011-09-29 | Manufacturing process for pyrimidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ624622A true NZ624622A (en) | 2014-10-31 |
Family
ID=51796566
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ624621A NZ624621A (en) | 2010-10-01 | 2011-09-29 | Manufacturing process for pyrimidine derivatives |
NZ624622A NZ624622A (en) | 2010-10-01 | 2011-09-29 | Manufacturing process for pyrimidine derivatives |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ624621A NZ624621A (en) | 2010-10-01 | 2011-09-29 | Manufacturing process for pyrimidine derivatives |
Country Status (1)
Country | Link |
---|---|
NZ (2) | NZ624621A (en) |
-
2011
- 2011-09-29 NZ NZ624621A patent/NZ624621A/en unknown
- 2011-09-29 NZ NZ624622A patent/NZ624622A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NZ624621A (en) | 2014-12-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PSEA | Patent sealed | ||
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 29 SEP 2016 BY CPA GLOBAL Effective date: 20150815 |
|
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 29 SEP 2017 BY CPA GLOBAL Effective date: 20160819 |
|
LAPS | Patent lapsed |