NZ618594B2 - Hepatitis c virus inhibitors - Google Patents

Hepatitis c virus inhibitors Download PDF

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Publication number
NZ618594B2
NZ618594B2 NZ618594A NZ61859412A NZ618594B2 NZ 618594 B2 NZ618594 B2 NZ 618594B2 NZ 618594 A NZ618594 A NZ 618594A NZ 61859412 A NZ61859412 A NZ 61859412A NZ 618594 B2 NZ618594 B2 NZ 618594B2
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New Zealand
Prior art keywords
pyrrolo
dioxo
hexadecahydrocyclopropa
dimethyl
diazacyclopentadecin
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NZ618594A
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NZ618594A (en
Inventor
Pvk Suresh Babu
Michael S Bowsher
Eric P Gillis
Sheldon Hiebert
Nicholas A Meanwell
Eric Mull
Pulicharla Nagalakshmi
Ramkumar Rajamani
Kishore V Renduchintala
Kandhasamy Sarkunam
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Bristolmyers Squibb Company
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Priority claimed from US13/459,403 external-priority patent/US8957203B2/en
Application filed by Bristolmyers Squibb Company filed Critical Bristolmyers Squibb Company
Publication of NZ618594A publication Critical patent/NZ618594A/en
Publication of NZ618594B2 publication Critical patent/NZ618594B2/en

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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Abstract

Disclosed are macrocyclic peptide-based inhibitors of hepatitis C virus (HCV) compounds of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are: 1,1,1-trifluoro-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)-7-ethyl-2-(4-methoxyisoquinolin-1-yloxy)-9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16ahexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-ylcarbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((3-methoxyisoquinolin-1-yl)oxy)-9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16ahexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate and (2R,6S,7R,9R,13aR,14aR,16aS)-6-(3-(tert-butyl)ureido)-N-((1- (fluoromethyl)cyclopropyl)sulfonyl)-2-((4-methoxyisoquinolin-1-yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide. onylcarbamoyl)-7-ethyl-2-(4-methoxyisoquinolin-1-yloxy)-9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16ahexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-ylcarbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((3-methoxyisoquinolin-1-yl)oxy)-9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16ahexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate and (2R,6S,7R,9R,13aR,14aR,16aS)-6-(3-(tert-butyl)ureido)-N-((1- (fluoromethyl)cyclopropyl)sulfonyl)-2-((4-methoxyisoquinolin-1-yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide.

Claims (28)

  1. CLAIMS 5 1. A compound of formula (I) (I), or a pharmaceutically acceptable salt thereof, wherein p is 1 or 2; 10 ----- is a single or double bond; R is selected from (R ) and ; wherein R is attached to the parent molecular moiety through any substitutable carbon atom in the group; 15 m is 0, 1, or 2; n is 0, 1, 2, 3, 4, 5, or 6; X is selected from CH and N; X is selected from CH and N; 2 3 a X and X are independently selected from CH, C(R ) and N; provided that at 1 2 3 20 least one of X , X , and X is other than N; each R is independently selected from alkenyloxy, alkoxy, alkoxyalkoxy, alkyl, benzodioxanyl, carboxamido, carboxy, carboxyalkoxy, cyano, cycloalkylalkoxy, cycloalkyloxy, deuteroalkoxy, dialkylamino, halo, haloalkyl, 11757-WO-PCT haloalkoxy, haloalkoxycarbonyl, hydroxy, morpholinyl, phenyl, piperazinyl, pyrazolyl, and pyridinyl, pyrrolidinyl, wherein the morpholinyl, the phenyl, the piperazinyl, the pyridinyl, and the pyrrolidinyl are optionally substituted with one or two groups independently selected from alkoxy, alkyl, alkylsulfonyl, halo, 5 haloalkoxy, haloalkyl, and morpholinyl; and wherein two adjacent R groups, together with the carbon atoms to which they are attached, can optionally form a ring selected from dioxanyl, dioxolanyl, morpholinyl, pyranyl, and phenyl, wherein the ring is optionally substituted with one or two groups independently selected from alkyl and halo; 10 R is alkyl; R is selected from methyl and ethyl; R and R are independently selected from hydrogen and hydroxy; provided that when ----- is a double bond, R and R are each hydrogen; R is selected from hydrogen, alkyl, halo, haloalkoxy, haloalkyl, and 15 hydroxyalkyl; and R is selected from hydrogen, alkoxyalkoxycarbonyl, alkoxycarbonyl, alkylaminocarbonyl, alkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylcarbonyl, cycloalkyloxycarbonyl, deuteroalkoxycarbonyl, deuterohaloalkoxycarbonyl, dialkylaminocarbonyl, dialkylaminocarbonylcarbonyl, haloalkoxycarbonyl, 20 haloalkylaminocarbonyl, haloalkylcarbonyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, phenylcarbonyl, and phenyloxycarbonyl, wherein the cycloalkyl part of the cycloalkylalkoxycarbonyl, the cycloalkylcarbonyl, and the cycloalkyloxycarbonyl, the heterocyclyl part of the heterocyclylcarbonyl and the heterocyclyloxycarbonyl, and the phenyl part of the phenylcarbonyl and the 25 phenyloxycarbonyl, is optionally substituted with one , two, or three groups independently selected from alkyl, alkylamino, alkylcarbonyl, cycloalkyl, dialkylamino, halo, haloalkoxy, and haloalkyl.
  2. 2. A compound of claim 1, or a pharmaceutically acceptable salt thereof, 30 wherein m is 1.
  3. 3. A compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein ----- is a double bond. 11757-WO-PCT
  4. 4. A compound of claim 3, or a pharmaceutically acceptable salt thereof, wherein R is methyl.
  5. 5. A compound of claim 1, or a pharmaceutically acceptable salt thereof, 5 wherein R is wherein X and X are N; X is C(R ); n and R are as defined in claim 1; and 10 “ ” denotes the point of attachment to the parent molecular moiety.
  6. 6. A compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R is 15 wherein X is N; 2 3 a X and X are independently selected from CH and C(R ); n and R are as defined in claim 1; and “ ” denotes the point of attachment to the parent molecular moiety. 20
  7. 7. A compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R is 11757-WO-PCT wherein X and X are N; X is C(R ); n and R are as defined in claim 1; and 5 “ ” denotes the point of attachment to the parent molecular moiety.
  8. 8. A compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R is 1 2 a 10 wherein X and X are independently selected from CH and C(R ); X is N; n and R are as defined in claim 1; and “ ” denotes the point of attachment to the parent molecular moiety. 15
  9. 9. A compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R is wherein X and X are N; X is CH; 20 n and R are as defined in claim 1; and 11757-WO-PCT “ ” denotes the point of attachment to the parent molecular moiety.
  10. 10. A compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R is wherein X and X are N; X is selected from CH and C(R ); n and R are as defined in claim 1; and “ ” denotes the point of attachment to the parent molecular moiety.
  11. 11. A compound of claim 1, of formula (II) (R ) (II), or a pharmaceutically acceptable salt thereof, wherein 15 n is 0, 1, 2, 3, 4, 5, or 6; X is selected from CH and N; 2 3 1 X and X are independently selected from CH, C(R ) and N; R is selected from methyl and ethyl; each R is independently selected from alkoxy, alkyl, carboxamido, carboxy, 11757-WO-PCT cyano, cycloalkyloxy, dialkylamino, halo, haloalkyl, haloalkoxy, phenyl, and pyridinyl, wherein the phenyl and the pyridinyl are optionally substituted with one or two groups independently selected from alkoxy, alkyl, halo, haloalkoxy, and haloalkyl; 5 R is selected from hydrogen, alkyl, halo, and haloalkyl; and R is selected from alkoxycarbonyl, alkylcarbonyl, haloalkoxycarbonyl, haloalkylcarbonyl, and phenylcarbonyl, wherein the phenyl is optionally substituted with one or two groups independently selected from alkyl and halo. 10
  12. 12. A compound of claim 1, of formula (III) (R ) (III), or a pharmaceutically acceptable salt thereof, wherein n is 0, 1, 2, 3, 4, 5, or 6; 15 each R is independently selected from alkoxy, alkyl, carboxamido, carboxy, cyano, cycloalkyloxy, dialkylamino, halo, haloalkyl, haloalkoxy, and phenyl, wherein the phenyl is optionally substituted with one or two groups independently selected from alkoxy, alkyl, halo, haloalkoxy, and haloalkyl; R is selected from hydrogen, alkyl, halo, and haloalkyl; and 20 R is selected from alkoxycarbonyl, alkylcarbonyl, haloalkoxycarbonyl, haloalkylcarbonyl, and phenylcarbonyl, wherein the phenyl is optionally substituted with one or two groups independently selected from alkyl and halo; 11757-WO-PCT or a pharmaceutically acceptable salt thereof.
  13. 13. A compound of claim 1, selected from tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- 5 ((cyclopropylsulfonyl)carbamoyl)((3-isopropyloxo-3,4-dihydrophthalazin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 10 ((cyclopropylsulfonyl)carbamoyl)((3-isopropyloxo-3,4-dihydrophthalazin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-isopropyloxo-3,4- 15 dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-isopropyloxo-3,4- 20 dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(2-methoxyethyl)oxo- 25 3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-(2-methoxyethyl)oxo- 30 3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(2-methoxyethyl)oxo-3,4- dihydrophthalazinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 5 a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(2-methoxyethyl)oxo-3,4- dihydrophthalazinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 10 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-isopropyloxo-3,4-dihydrophthalazin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-isopropyloxo-3,4-dihydrophthalazin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3- isopropyloxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 25 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- isopropyloxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 30 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3- (2-methoxyethyl)oxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- (2-methoxyethyl)oxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- 5 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3- isopropyloxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- 10 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- isopropyloxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-isopropyloxo-3,4-dihydrophthalazin 20 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-isopropyloxo-3,4-dihydrophthalazin 25 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(2- methoxyethyl)oxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- 30 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 11757-WO-PCT 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-(2- methoxyethyl)oxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 5 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(2-methoxyethyl)oxo-3,4- dihydrophthalazinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 10 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(2-methoxyethyl)oxo-3,4- dihydrophthalazinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 15 a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(2-methoxyethyl)oxo-3,4- dihydrophthalazinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 20 a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(2-methoxyethyl)oxo-3,4- dihydrophthalazinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 25 a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((4-(2,2- difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 30 a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((4-(2,2- difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((4-(2- methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 5 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((4-(2,2-difluoroethoxy)isoquinolinyl)oxy)- 10 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((4- (2,2-difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((4- (2,2-difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 20 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((4-(2,2-difluoroethoxy)isoquinolinyl)oxy)- 25 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((4-(2,2-difluoroethoxy)isoquinolinyl)oxy)- 30 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((4-(2-methoxyethoxy)isoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((4-(2,2-difluoroethoxy)isoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((4-(2,2- difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 15 a][1,4]diazacyclopentadecinyl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((4-(2,2- difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 20 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((4- (2-methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 25 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((4- (2-methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 30 a][1,4]diazacyclopentadecinyl)carbamate; (1S,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((4- (2-methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; (1S,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((4-(2-methoxyethoxy)isoquinolinyl)oxy)- 5 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; oxetanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 10 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 15 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 20 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-pentyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 25 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3-methyloxetanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 30 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 3-(trifluoromethyl)oxetanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; 4-(trifluoromethyl)tetrahydro-2H-pyranyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 10 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 4-(trifluoromethyl)tetrahydro-2H-pyranyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 15 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1-methoxymethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 20 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1-methoxymethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 25 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 4-methyltetrahydro-2H-pyranyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolin 30 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 4-methyltetrahydro-2H-pyranyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; 3-isopropyloxetanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; 3-isopropyloxetanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 3-methyltetrahydro-2H-pyranyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; 3-methyltetrahydro-2H-pyranyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; 3-(trifluoromethyl)tetrahydro-2H-pyranyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 30 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3-(trifluoromethyl)tetrahydro-2H-pyranyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- 11757-WO-PCT (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 5 3-cyclopropyloxetanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 3-cyclopropyloxetanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 15 4,4,4-trifluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 20 4,4,4-trifluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 3-methyltetrahydrofuranyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 30 3-methyltetrahydrofuranyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3-(trifluoromethyl)tetrahydrofuranyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolin- 5 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3-(trifluoromethyl)tetrahydrofuranyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolin- 10 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxyisoquinolinyl)oxy)-7,9-dimethyl- 15 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxyisoquinolinyl)oxy)-7,9-dimethyl- 20 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5-chloro propoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 25 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5-chloro propoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 30 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5-chloro propoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 5 a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5-chloro propoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 10 a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5-chloro(2,2- difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 15 a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5-chloro(2,2- difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 20 a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5-chloro(2,2- difluoroethoxy)isoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5-chloro(2,2- difluoroethoxy)isoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloropropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloropropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 5 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloropropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 10 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloropropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloropropoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- 20 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloropropoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- 25 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloropropoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- 30 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloropropoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; (1S,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloropropoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; (1S,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloropropoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; (1S,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloropropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 20 a][1,4]diazacyclopentadecinyl)carbamate; (1S,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloropropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 25 a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5-chloro isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 30 a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5-chloro isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5-chloro isopropoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- 5 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5-chloro isopropoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- 10 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloroisopropoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)- 15 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloroisopropoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)- 20 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloro(2,2-difluoroethoxy)isoquinolinyl)oxy)-14a- 25 ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloro(2,2-difluoroethoxy)isoquinolinyl)oxy)-14a- 30 ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloro(2,2-difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 5 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloro(2,2-difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 10 a][1,4]diazacyclopentadecinyl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloro(2,2-difluoroethoxy)isoquinolinyl)oxy)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 15 a][1,4]diazacyclopentadecinyl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloro(2,2-difluoroethoxy)isoquinolinyl)oxy)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 20 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloroisopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 25 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloroisopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 30 a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloroisopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloroisopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 5 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloroisopropoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)- 10 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloroisopropoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)- 15 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloro(2,2-difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 20 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloro(2,2-difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 25 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloro(2,2-difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 30 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 11757-WO-PCT 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloro(2,2-difluoroethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 5 a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloro(2,2-difluoroethoxy)isoquinolinyl)oxy)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 10 a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloro(2,2-difluoroethoxy)isoquinolinyl)oxy)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 15 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloro(2-methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 20 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloro(2-methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 25 a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5- chloro(2-methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 30 a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5- chloro(2-methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5-chloro(2- methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 5 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5-chloro(2- methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 10 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3,6-dimethoxyisoquinolinyl)oxy)ethylmethyl-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3,6-dimethoxyisoquinolinyl)oxy)ethylmethyl-14a-(((1- 20 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3-(trifluoromethyl)oxetanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3,6- dimethoxyisoquinolinyl)oxy)ethylmethyl-14a-(((1- 25 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3-(trifluoromethyl)oxetanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3,6- dimethoxyisoquinolinyl)oxy)ethylmethyl-14a-(((1- 30 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 11757-WO-PCT 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3,6- dimethoxyisoquinolinyl)oxy)ethylmethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 5 a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3,6- dimethoxyisoquinolinyl)oxy)ethylmethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 10 a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3,6-dimethoxyisoquinolin yl)oxy)-14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3,6-dimethoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 20 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3,6-dimethoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 25 a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3,6- dimethoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 30 a][1,4]diazacyclopentadecinyl)carbamate; oxetanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3,6- dimethoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3,6-dimethoxyisoquinolin yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 5 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3,6-dimethoxyisoquinolin yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 10 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3,6-dimethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 15 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3,6-dimethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 20 a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(ethyl(methyl)amino) methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 25 a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-(ethyl(methyl)amino) methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 30 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3- (ethyl(methyl)amino)methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- (ethyl(methyl)amino)methoxyisoquinolinyl)oxy)-14a-(((1- 5 (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3- (ethyl(methyl)amino)methoxyisoquinolinyl)oxy)-14a-(((1- 10 (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- (ethyl(methyl)amino)methoxyisoquinolinyl)oxy)-14a-(((1- 15 (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3-(trifluoromethyl)oxetanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3,6- dimethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 20 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3-(trifluoromethyl)oxetanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3,6- dimethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 25 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxyisoquinolinyl)oxy)- 30 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6- methoxy(2-methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 10 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6- methoxy(2-methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 15 a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxy(2-methoxyethoxy)isoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxy(2-methoxyethoxy)isoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6- methoxy(2-methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 30 a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6- methoxy(2-methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxy(2-methoxyethoxy)isoquinolin 5 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxy(2-methoxyethoxy)isoquinolin 10 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6-methoxy(2- methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6-methoxy(2- methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 20 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxy(2-methoxyethoxy)isoquinolin 25 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxy(2-methoxyethoxy)isoquinolin 30 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT oxetanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6-methoxy(2- methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 5 a][1,4]diazacyclopentadecinyl)carbamate; oxetanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6-methoxy(2- methoxyethoxy)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 10 a][1,4]diazacyclopentadecinyl)carbamate; oxetanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxy(2-methoxyethoxy)isoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; oxetanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxy(2-methoxyethoxy)isoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((7-chloro methoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((7-chloro methoxyisoquinolinyl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-chloro methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-chloro methoxyisoquinolinyl)oxy)-14a-(((1- 5 (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3- chloromethoxyisoquinolinyl)oxy)-14a-(((1- 10 (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- chloromethoxyisoquinolinyl)oxy)-14a-(((1- 15 (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxy 20 (trifluoromethyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxy 25 (trifluoromethyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxy 30 (trifluoromethyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxy (trifluoromethyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 5 a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxy (trifluoromethyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 10 a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxy (trifluoromethyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 15 a][1,4]diazacyclopentadecinyl)carbamate; 3-(trifluoromethyl)tetrahydro-2H-pyranyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxy (trifluoromethyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3-(trifluoromethyl)tetrahydro-2H-pyranyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxy 25 (trifluoromethyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxy 30 (trifluoromethyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxy (trifluoromethyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 5 a][1,4]diazacyclopentadecinyl)carbamate; 3-(trifluoromethyl)tetrahydro-2H-pyranyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxy (trifluoromethyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3-(trifluoromethyl)tetrahydro-2H-pyranyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxy 15 (trifluoromethyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3-(trifluoromethyl)tetrahydro-2H-pyranyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3,6-dimethoxyisoquinolinyl)oxy)ethyl- 20 9-methyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3-(trifluoromethyl)tetrahydro-2H-pyranyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3,6-dimethoxyisoquinolinyl)oxy)ethyl- 25 9-methyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (difluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((3,6-dimethoxyisoquinolin 30 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (((1-(difluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((3,6-dimethoxyisoquinolin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (difluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((3,6-dimethoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS)((4- cyclopropoxyisoquinolinyl)oxy)hydroxy-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxooctadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13S,13aR,14aR,16aS) ((4-cyclopropoxyisoquinolinyl)oxy)hydroxy-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxooctadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; 2-((1-(((2R,6S,7R,9R,13aS,14aR,16aS,Z)((tert-butoxycarbonyl)amino)- 7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)oxy)isoquinolinyl)oxy)acetic acid; 25 tert-butyl tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (cyclopropylsulfonylcarbamoyl)ethyl(7-fluoromethoxyisoquinolin yloxy)methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 30 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)ethyl(7-fluoromethoxyisoquinolin- 1-yloxy)methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (cyclopropylsulfonylcarbamoyl)ethyl(7-fluoromethoxyisoquinolin 5 yloxy)methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)ethyl(7-fluoromethoxyisoquinolin- 10 1-yloxy)methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (cyclopropylsulfonylcarbamoyl)ethyl(6-methoxyisoquinolinyloxy) 15 methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)ethyl(6-methoxyisoquinolinyloxy)- 20 9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (cyclopropylsulfonylcarbamoyl)ethyl(4-methoxyisoquinolinyloxy) 25 methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)ethyl(4-methoxyisoquinolinyloxy)- 30 9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (cyclopropylsulfonylcarbamoyl)(4-ethoxyisoquinolinyloxy)ethyl methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)(4-ethoxyisoquinolinyloxy)ethyl methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)(4-ethoxyisoquinolinyloxy)ethyl methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (6-methoxy(4-methylpiperazinyl)isoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (5-chloromethoxyisoquinolinyloxy)-14a-(1- fluorocyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT (2R,6S,7R,9R,13aS,14aR,16aS,Z)-N-(1-fluorocyclopropylsulfonyl)(6- methoxyisoquinolinyloxy)-7,9-dimethyl-5,16-dioxopivalamido- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 5 carboxamide; isopropyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- fluorocyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (5-chloroisopropoxyisoquinolinyloxy)-14a- (cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; isobutyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- fluorocyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; cyclopentyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- fluorocyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; (R)-1,1,1-trifluoropropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- fluorocyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 30 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- fluorocyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)-7,9- 11757-WO-PCT dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; neopentyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- 5 fluorocyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 10 14a-(1-fluorocyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-chloro 15 methoxyisoquinolinyloxy)-14a-(1-fluorocyclopropylsulfonylcarbamoyl)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) 20 (5-chloroethoxyisoquinolinyloxy)-14a-(cyclopropylsulfonylcarbamoyl)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 25 (cyclopropylsulfonylcarbamoyl)(3-(4-isopropoxyphenyl) methoxyisoquinolinyloxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 30 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)(3-(4-isopropoxyphenyl) methoxyisoquinolinyloxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (4-chloromethoxyisoquinolinyloxy)-14a-(1- 5 fluorocyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(2-fluorobenzamido)-N-(1- 10 fluorocyclopropylsulfonyl)(6-methoxyisoquinolinyloxy)-7,9-dimethyl-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) 15 (4-(cyclopropylmethoxy)isoquinolinyloxy)-14a- (cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 20 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (5-chloro(difluoromethoxy)isoquinolinyloxy)-14a- (cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (cyclopropylsulfonylcarbamoyl)(7-methoxyquinazolinyloxy)-7,9-dimethyl- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 ylcarbamate; tert-butyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- (cyclopropylsulfonylcarbamoyl)(7-methoxyquinazolinyloxy)-7,9-dimethyl- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)(7-methoxyquinazolinyloxy)-7,9- 5 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; (1-methylcyclopropyl)methyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- fluorocyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)-7,9- 10 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; cyclohexyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- fluorocyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)-7,9- 15 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; (1R,5S)-bicyclo[3.1.0]hexanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (1-fluorocyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)-7,9- 20 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (7-fluoromethoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- 25 methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 30 14a-(cyclopropylsulfonylcarbamoyl)(isoquinolinyloxy)-7,9-dimethyl-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (4-ethoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; neopentyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-chloro methoxyisoquinolinyloxy)-14a-(1-fluorocyclopropylsulfonylcarbamoyl)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 10 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (7-chloromethoxyisoquinolinyloxy)-14a-(1- fluorocyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 15 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z) (7-chloromethoxyisoquinolinyloxy)-14a-(1- 20 fluorocyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoro 25 methoxyisoquinolinyloxy)-14a-(1-fluorocyclopropylsulfonylcarbamoyl)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)(7-fluoro 30 methoxyisoquinolinyloxy)-14a-(1-fluorocyclopropylsulfonylcarbamoyl)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT neopentyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoro methoxyisoquinolinyloxy)-14a-(1-fluorocyclopropylsulfonylcarbamoyl)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 ylcarbamate; (1-methylcyclopropyl)methyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7- fluoromethoxyisoquinolinyloxy)-14a-(1- fluorocyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 10 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoro methoxyisoquinolinyloxy)-14a-(1-fluorocyclopropylsulfonylcarbamoyl)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; (1-methylcyclopropyl)methyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7- fluoromethoxyisoquinolinyloxy)-14a-(1- fluorocyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; neopentyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoro methoxyisoquinolinyloxy)-14a-(1-fluorocyclopropylsulfonylcarbamoyl)-7,9- 25 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (4-methoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- 30 methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4-ethoxyisoquinolin yloxy)-14a-(1-fluorocyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 ylcarbamate; 1-methylcyclopropyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (cyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)-7,9-dimethyl- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 ylcarbamate; cyclohexyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4- cyclopropoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (4-cyclopropoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4-methoxyisoquinolin yloxy)-7,9-dimethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)(4-methoxyisoquinolin yloxy)-7,9-dimethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)(7-fluoromethoxyisoquinolinyloxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (7-fluoromethoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 10 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (cyclopropylsulfonylcarbamoyl)(4-ethoxyfluoroisoquinolinyloxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)(4-ethoxyfluoroisoquinolinyloxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(4-isopropoxyphenyl)- 6-methoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (3-(4-isopropoxyphenyl)methoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- 30 methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (5-chloromethoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; (R)-1,1,1-trifluoropropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4- ethoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (4-(cyclopropylmethoxy)fluoroisoquinolinyloxy)-14a- 15 (cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) 20 (7-fluoromethoxyisoquinolinyloxy)-14a-(1- fluorocyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 25 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (7-fluoromethoxyisoquinolinyloxy)-14a-(1- fluorocyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoro-4,6- dimethoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 5 (cyclopropylsulfonylcarbamoyl)(7-fluoroisoquinolinyloxy)-7,9-dimethyl- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 10 14a-(cyclopropylsulfonylcarbamoyl)(7-fluoroisoquinolinyloxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1-methylcyclopropyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 15 (cyclopropylsulfonylcarbamoyl)(7-fluoroisoquinolinyloxy)-7,9-dimethyl- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 20 (cyclopropylsulfonylcarbamoyl)(7-fluoro-4,6-dimethoxyisoquinolinyloxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-chloro 25 ethoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 30 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (7-chloroethoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(1-ethylcyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)- 5 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(4-tert-butylphenyl) methoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- 10 methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) 15 (3-(4-tert-butylphenyl)methoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 20 tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4,6-dimethoxyisoquinolin- 1-yloxy)-7,9-dimethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 25 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (4,6-dimethoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoro methoxyisoquinolinyloxy)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) 5 (7-fluoromethoxyisoquinolinyloxy)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 10 tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoro-4,6- dimethoxyisoquinolinyloxy)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(6-methoxyquinoxalin yloxy)-7,9-dimethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-methoxyquinoxalin yloxy)-7,9-dimethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(6-methoxy(6- methoxypyridinyl)isoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 30 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(1-(fluoromethyl)cyclopropylsulfonylcarbamoyl)(7-methoxyquinoxalin 11757-WO-PCT yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- 5 (fluoromethyl)cyclopropylsulfonylcarbamoyl)(7-methoxyquinoxalinyloxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoromethoxyisoquinolin 10 yloxy)-N-(1-(fluoromethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo(1- (trifluoromethyl)cyclopropanecarboxamido)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 15 (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoromethoxyisoquinolin yloxy)-N-(1-(fluoromethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo (3,3,3-trifluoro-2,2-dimethylpropanamido)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 20 carboxamide; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-(1-(difluoromethyl)cyclopropylsulfonylcarbamoyl)(7-fluoro methoxyisoquinolinyloxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(1-(difluoromethyl)cyclopropylsulfonylcarbamoyl)(7-fluoro methoxyisoquinolinyloxy)-7,9-dimethyl-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-(1-(difluoromethyl)cyclopropylsulfonylcarbamoyl)(7-fluoro-4,6- dimethoxyisoquinolinyloxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(1-(difluoromethyl)cyclopropylsulfonylcarbamoyl)(7-fluoro-4,6- dimethoxyisoquinolinyloxy)-7,9-dimethyl-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoromethoxyisoquinolin yloxy)-N-(1-(fluoromethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo(2- 15 (trifluoromethyl)benzamido)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(2,4-difluorobenzamido)(7-fluoro- 6-methoxyisoquinolinyloxy)-N-(1-(fluoromethyl)cyclopropylsulfonyl)-7,9- 20 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(2,2-difluoroethylamino)-N-(1- (fluoromethyl)cyclopropylsulfonyl)(7-methoxyquinoxalinyloxy)-7,9- 25 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (6-fluoroquinoxalinyloxy)-7,9-dimethyl-14a-(1- 30 methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (7-fluoromethoxymorpholinoisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (4-ethoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (4-hydroxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- 15 methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) 20 (4-ethoxymethoxyisoquinolinyloxy)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 25 tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4-ethoxy methoxyisoquinolinyloxy)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (6-methoxy((1,1,1-trifluoromethylpropanyloxy)carbonyloxy)isoquinolin- 1-yloxy)-7,9-dimethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 5 14a-(1-(fluoromethyl)cyclopropylsulfonylcarbamoyl)(6-methoxy methylquinoxalinyloxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 10 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(1-(fluoromethyl)cyclopropylsulfonylcarbamoyl)(7-methoxy methylquinoxalinyloxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-methoxy methylquinoxalinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(1-(hydroxymethyl)cyclopropylsulfonylcarbamoyl)(4- methoxyisoquinolinyloxy)-7,9-dimethyl-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-(1-(hydroxymethyl)cyclopropylsulfonylcarbamoyl)(4- 30 methoxyisoquinolinyloxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT (2R,6S,7R,9R,13aS,14aR,16aS,Z)amino-N-(1- (hydroxymethyl)cyclopropylsulfonyl)(4-methoxyisoquinolinyloxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 5 carboxamide; (2R,6S,7R,9S,13aS,14aR,16aS,Z)amino-N-(1- (hydroxymethyl)cyclopropylsulfonyl)(4-methoxyisoquinolinyloxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 10 carboxamide; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- (hydroxymethyl)cyclopropylsulfonylcarbamoyl)(4-methoxyisoquinolin yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 ylcarbamate; tert-butyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(1- (hydroxymethyl)cyclopropylsulfonylcarbamoyl)(4-methoxyisoquinolin yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 ylcarbamate; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoro-4,6-dimethoxyisoquinolin- 1-yloxy)-N-(1-(fluoromethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo pivalamido-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 25 carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoro-4,6-dimethoxyisoquinolin- 1-yloxy)-N-(1-(fluoromethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo (2,4,6-trifluorobenzamido)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 30 carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(2,4-difluorobenzamido)(7-fluoro- 4,6-dimethoxyisoquinolinyloxy)-N-(1-(fluoromethyl)cyclopropylsulfonyl)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoro-4,6-dimethoxyisoquinolin- 1-yloxy)-N-(1-(fluoromethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo(1- 5 (trifluoromethyl)cyclopropanecarboxamido)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 10 14a-(1-(fluoromethyl)cyclopropylsulfonylcarbamoyl)(6-methoxy morpholinoisoquinolinyloxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 15 tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoro-4,6- dimethoxyisoquinolinyloxy)-14a-(1- (hydroxymethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 ylcarbamate; tert-butyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)(7-fluoro-4,6- dimethoxyisoquinolinyloxy)-14a-(1- (hydroxymethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(1-chlorocyclopropylsulfonylcarbamoyl)(4,6-dimethoxyisoquinolin yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 30 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- chlorocyclopropylsulfonylcarbamoyl)(4,6-dimethoxyisoquinolinyloxy)-7,9- 11757-WO-PCT dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)- 5 14a-(1-ethylcyclopropylsulfonylcarbamoyl)(7-fluoromethoxyisoquinolin yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 10 14a-(1-ethylcyclopropylsulfonylcarbamoyl)(7-fluoromethoxyisoquinolin yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 15 14a-(1-(fluoromethyl)cyclopropylsulfonylcarbamoyl)(3-(4-isopropoxyphenyl)- 6-methoxyisoquinolinyloxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 20 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (5-chloromethoxyisoquinolinyloxy)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo (quinoxalinyloxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4-((2S,6R)-2,6- dimethylmorpholino)methoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) 5 (4-((2S,6R)-2,6-dimethylmorpholino)methoxyisoquinolinyloxy)-7,9- dimethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 10 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 7,9-dimethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo(4- ((1,1,1-trifluoromethylpropanyloxy)carbonyloxy)isoquinolinyloxy)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo(4-(vinyloxy)isoquinolin yloxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (6-methoxymorpholinoisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4-ethoxy methoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(6-methoxy morpholinoisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 2,4-difluorophenyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4- ethoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 2-fluorophenyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4-ethoxyisoquinolin- 1-yloxy)-7,9-dimethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 15 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; phenyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4-ethoxyisoquinolin yloxy)-7,9-dimethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(1-acetylpiperidinecarboxamido)- 2-(4,6-dimethoxyisoquinolinyloxy)-7,9-dimethyl-N-(1- 25 methylcyclopropylsulfonyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4,6-dimethoxyisoquinolinyloxy)- 30 6-(3-fluoroisonicotinamido)-7,9-dimethyl-N-(1-methylcyclopropylsulfonyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 11757-WO-PCT (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4,6-dimethoxyisoquinolinyloxy)- 7,9-dimethyl(1-methyloxo-1,2-dihydropyridinecarboxamido)-N-(1- methylcyclopropylsulfonyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-methoxyquinazolin yloxy)-7,9-dimethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 10 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(8-chloroquinazolin yloxy)-7,9-dimethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolin yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(1-(fluoromethyl)cyclopropylsulfonylcarbamoyl)(2-(4-isopropoxyphenyl)- 7-methoxyquinolinyloxy)-7,9-dimethyl-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (4-ethoxyisoquinolinyloxy)-14a-(1- 30 (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z) (4-ethoxyisoquinolinyloxy)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(1-(fluoromethyl)cyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolin- 1-yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 10 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-(1-(fluoromethyl)cyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolin- 1-yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(1-chlorocyclopropylsulfonylcarbamoyl)(4-methoxyisoquinolinyloxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (4,6-dimethoxyisoquinolinyloxy)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(1-(fluoromethyl)cyclopropylsulfonylcarbamoyl)(4-methoxyisoquinolin- 30 1-yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4,6-dimethoxyisoquinolin- 1-yloxy)-14a-(1-(fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)(4-methoxyisoquinolin yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (4-(cyclopropylmethoxy)isoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoro methoxyisoquinolinyloxy)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (7-fluoro-4,6-dimethoxyisoquinolinyloxy)-14a-(1- 25 (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) 30 (7-fluoromethoxyisoquinolinyloxy)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (7-methoxyquinoxalinyloxy)-7,9-dimethyl-14a-(1- 5 methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) 10 (6-methoxyquinoxalinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 15 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (7-fluoro-4,6-dimethoxyisoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 ylcarbamate; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoromethoxyisoquinolin yloxy)-N-(1-(fluoromethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo pivalamido-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 25 carboxamide; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4-(cyclopropylmethoxy)- 7-fluoroisoquinolinyloxy)-14a-(cyclopropylsulfonylcarbamoyl)-7,9-dimethyl- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)(3-(4-isopropoxyphenyl) methoxyisoquinolinyloxy)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 5 14a-(cyclopropylsulfonylcarbamoyl)(7-fluoromethoxyisoquinolinyloxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(2,2-difluoroethylamino)-N-(1- 10 (fluoromethyl)cyclopropylsulfonyl)(7-methoxyquinoxalinyloxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4,6-dimethoxyisoquinolinyloxy)- 15 6-(3-fluoroisonicotinamido)-N-(1-(fluoromethyl)cyclopropylsulfonyl)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) 20 (2-(4-isopropoxyphenyl)methoxyquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 25 tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4-(4-(2,2- difluoroethyl)piperazinyl)methoxyisoquinolinyloxy)-7,9-dimethyl-14a- (1-ethylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl(4-methoxyisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)ethyl(7-fluoro 5 methoxyisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 10 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl(7-fluoromethoxyisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 ylcarbamate; (R)-1,1,1-trifluoropropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)ethyl- 2-(6-methoxyisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl(2R,6S,7R,9R,13aS,14aR,16aS,Z) (6-methoxy(6-methoxypyridinyl)isoquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-fluoroquinoxalin yloxy)-7,9-dimethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4-ethoxyisoquinolin yloxy)ethylmethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)ethyl(7-fluoro methoxyisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 10 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl(6-methoxyisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 15 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(7-methoxy (trifluoromethyl)quinoxalinyloxy)-7,9-dimethyl-14a-(1- 20 methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)- 25 14a-(cyclopropylsulfonylcarbamoyl)(4-ethoxyisoquinolinyloxy)ethyl methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 30 14a-(cyclopropylsulfonylcarbamoyl)(4-ethoxyisoquinolinyloxy)ethyl methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl(7-fluoromethoxyisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z) ethyl(7-fluoromethoxyisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (7-chloromethoxyisoquinolinyloxy)ethylmethyl-14a-(1- 15 methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 20 14a-(cyclopropylsulfonylcarbamoyl)ethyl(7-methoxyquinazolinyloxy) methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) 25 (7-chloromethoxyisoquinolinyloxy)-14a-(cyclopropylsulfonylcarbamoyl)- 7-ethylmethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z) 30 (4-ethoxymethoxyisoquinolinyloxy)ethylmethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z) ethyl(7-fluoromethoxymorpholinoisoquinolinyloxy)methyl-14a-(1- 5 methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) 10 ethyl(7-fluoromethoxyisoquinolinyloxy)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)methyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 15 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)ethyl(7-methoxyquinoxalinyloxy)- 9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 20 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (7-methoxy(trifluoromethyl)quinoxalinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4,6-dimethoxyisoquinolin- 1-yloxy)ethylmethyl-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (4,6-dimethoxyisoquinolinyloxy)ethylmethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 5 14a-(1-(fluoromethyl)cyclopropylsulfonylcarbamoyl)(7-methoxyquinolin yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) 10 (2-chloromethoxyquinolinyloxy)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 15 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) (4-ethoxyisoquinolinyloxy)ethylmethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)ethyl(6- methoxyisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)ethyl-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolin yloxy)methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 30 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl-14a-(1-(fluoromethyl)cyclopropylsulfonylcarbamoyl)(6- 11757-WO-PCT methoxyisoquinolinyloxy)methyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 5 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl(6-methoxymorpholinoisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z) ethyl(6-methoxymorpholinoisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9S,13aS,14aR,16aS,Z) ethyl(7-fluoro-4,6-dimethoxyisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin ylcarbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-(dimethylamino)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 25 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) 30 ((3-(dimethylamino)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(dimethylamino) methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 5 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-(dimethylamino) 10 methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 15 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclobutylsulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 20 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclobutylsulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclobutylsulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 30 tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclobutylsulfonyl)carbamoyl)((4-methoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aR,14aR,16aS)-14a- (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolin 5 yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aR,14aR,16aS)- 14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4- methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16- 10 dioxooctadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aR,14aR,16aS)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2- 15 a][1,4]diazacyclopentadecinyl)carbamate; tert-butyl ((2R,6S,7R,9R,13aR,14aR,16aS)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 20 tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((2-(dimethylamino) methoxyquinazolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((2-(dimethylamino) methoxyquinazolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 30 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((2-(dimethylamino)methoxyquinazolinyl)oxy)-7,9-dimethyl-14a-(((1- 11757-WO-PCT methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 5 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((2-(dimethylamino)methoxyquinazolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((2-(dimethylamino) methoxyquinazolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((2-(dimethylamino) methoxyquinazolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((2-(4-isopropoxyphenyl)- 7-methoxyquinazolinyl)oxy)-7,9-dimethyl-14a-(((1- 25 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((2-(4-isopropoxyphenyl)- 30 7-methoxyquinazolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((2-(dimethylamino)methoxyquinazolinyl)oxy)-14a-(((1- 5 (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) 10 ((2-(dimethylamino)methoxyquinazolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 15 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((2-(4-isopropoxyphenyl)methoxyquinazolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((2-(4-isopropoxyphenyl)methoxyquinazolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((7-methoxy(pyrrolidin yl)quinazolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((7-methoxy(pyrrolidin yl)quinazolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((2,7- dimethoxyquinazolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2-(4-isopropoxyphenyl) 15 methoxyquinazolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 20 ((cyclopropylsulfonyl)carbamoyl)((2-(4-isopropoxyphenyl) methoxyquinazolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((7-methoxy (pyrrolidinyl)quinazolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((7-methoxy (pyrrolidinyl)quinazolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) 5 ((2,7-dimethoxyquinazolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((2-(4-isopropoxyphenyl) methoxyquinazolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((2-(4-isopropoxyphenyl) methoxyquinazolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)ethyl((5- methoxyisoquinolinyl)oxy)methyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)ethyl((5- methoxyisoquinolinyl)oxy)methyl-14a-(((1- 30 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)ethyl((5-methoxyisoquinolinyl)oxy) methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)ethyl((5-methoxyisoquinolinyl)oxy) methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ethyl((5-methoxyisoquinolinyl)oxy)methyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl((5-methoxyisoquinolinyl)oxy)methyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)ethyl((5-methoxyisoquinolinyl)oxy)methyl- 25 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)ethyl((5-methoxyisoquinolinyl)oxy)methyl- 30 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)ethyl((5-methoxyisoquinolin yl)oxy)methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)ethyl((5-methoxyisoquinolin yl)oxy)methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)ethyl((5- methoxyisoquinolinyl)oxy)methyl-N-((1-methylcyclopropyl)sulfonyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 15 carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)ethyl((5- methoxyisoquinolinyl)oxy)methyl-N-((1-methylcyclopropyl)sulfonyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 20 carboxamide; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((5-methoxyisoquinolin yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((5-methoxyisoquinolin yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((5-methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) 5 ((5-methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((5-methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 15 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((5- methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(4-fluorophenyl)methoxyisoquinolin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(4-fluorophenyl)methoxyisoquinolin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(4-fluorophenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 5 14a-((cyclopropylsulfonyl)carbamoyl)((3-(4-fluorophenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(4-fluorophenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(4-fluorophenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(3-chloro methoxyphenyl)methoxyisoquinolinyl)oxy)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-(3-chloro methoxyphenyl)methoxyisoquinolinyl)oxy)-14a- 30 ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoromethoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoromethoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-(3-chloromethoxyphenyl)methoxyisoquinolinyl)oxy)-14a- 15 ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) 20 ((3-(3-chloromethoxyphenyl)methoxyisoquinolinyl)oxy)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-(3-chloromethoxyphenyl)methoxyisoquinolinyl)oxy)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 2-((3-(3-chloromethoxyphenyl)methoxyisoquinolinyl)oxy)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 5 14a-((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoromethoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoromethoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoromethoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoromethoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoroisopropoxyphenyl) 30 methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoroisopropoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(3-fluoro isopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-(3-fluoro isopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 20 14a-((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoroisopropoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoroisopropoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoroisopropoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 5 ((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoroisopropoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 (1-methylcyclopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(3- fluoroisopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a- (((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- (3-fluoroisopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl- 14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoroisopropoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoroisopropoxyphenyl) 30 methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-(3-fluoroisopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 2-((3-(3-fluoroisopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoroisopropoxyphenyl) 15 methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 20 ((cyclopropylsulfonyl)carbamoyl)((3-(3-fluoroisopropoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3- (3-fluoroisopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl- 14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- (3-fluoroisopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl- 14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) 5 ((3-(3-fluoroisopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3-(3-fluoroisopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-(4-fluorophenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3-(4-fluorophenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(4-fluorophenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 30 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-(4-fluorophenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- (4-fluorophenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(4- fluorophenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- 20 (4-fluorophenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-(4-fluorophenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 2-((3-(4-fluorophenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6-methoxy 5 morpholinoisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6-methoxy morpholinoisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6- methoxymorpholinoisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6- methoxymorpholinoisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6- methoxymorpholinoisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 30 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((6-methoxymorpholinoisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((6-methoxymorpholinoisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((6-methoxymorpholinoisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 20 2-((6-methoxymorpholinoisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-methoxymorpholinoisoquinolin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 30 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-methoxymorpholinoisoquinolin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)((6- 5 methoxymorpholinoisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl 10 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)((6- methoxymorpholinoisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 15 (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxymorpholinoisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 20 (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxymorpholinoisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-methoxymorpholinoisoquinolin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 30 (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-methoxymorpholinoisoquinolin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxymorpholinoisoquinolin 5 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxymorpholinoisoquinolin 10 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-(dimethylamino)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 20 2-((3-(dimethylamino)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3- (dimethylamino)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- (dimethylamino)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl 5 ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(dimethylamino)methoxyisoquinolin- 1-yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-(dimethylamino) methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((6-methoxy(pyrrolidinyl)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((6-methoxy(pyrrolidinyl)isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 25 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- 30 ((cyclopropylsulfonyl)carbamoyl)((3-(dimethylamino)methoxyisoquinolin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(dimethylamino)methoxyisoquinolin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(dimethylamino) methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 10 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-(dimethylamino) methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 15 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3- (dimethylamino)methoxyisoquinolinyl)oxy)-14a-(((1- 20 (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- 25 (dimethylamino)methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 30 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-(dimethylamino)methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3-(dimethylamino)methoxyisoquinolinyl)oxy)-14a-(((1- 5 (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- 10 (dimethylamino)methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 15 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(dimethylamino) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(dimethylamino) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(dimethylamino)methoxyisoquinolin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 30 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(dimethylamino)methoxyisoquinolin- 11757-WO-PCT 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- 5 ((cyclopropylsulfonyl)carbamoyl)((3-(dimethylamino)methoxyisoquinolin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 10 ((cyclopropylsulfonyl)carbamoyl)((3-(dimethylamino)methoxyisoquinolin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6-(dimethylamino) 15 methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 20 tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6-(dimethylamino) methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((6-(dimethylamino)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 30 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((6-(dimethylamino)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 11757-WO-PCT methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 5 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((6-ethoxymethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((6-ethoxymethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6-(dimethylamino) methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6-(dimethylamino) methoxyisoquinolinyl)oxy)-14a-(((1- 25 (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) 30 ((6-(dimethylamino)methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((6-(dimethylamino)methoxyisoquinolinyl)oxy)-14a-(((1- 5 (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6-fluoro 10 methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 15 tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6-fluoro methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((5-fluoromethoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((5-fluoromethoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((5-fluoromethoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((5-fluoromethoxyisoquinolin 5 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((5-fluoromethoxyisoquinolin 10 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((5-fluoromethoxyisoquinolin 15 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((7-fluoro methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 20 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((7-fluoro 25 methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 30 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((7-fluoromethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((7-fluoromethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 5 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((7- 10 fluoromethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 15 (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((7- fluoromethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((7-fluoromethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 2-((7-fluoromethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT (1-methylcyclopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((7- fluoromethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((7- fluoromethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((7-fluoromethoxyisoquinolinyl)oxy)- 15 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((7-fluoromethoxyisoquinolinyl)oxy)- 20 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((7-fluoromethoxyisoquinolin 25 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((7-fluoromethoxyisoquinolin 30 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((7-fluoromethoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((7-fluoromethoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((7-fluoromethoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((7-fluoromethoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((7-fluoromethoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((7-fluoromethoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((7-fluoro methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((7-fluoro 5 methoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((7-fluoromethoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((7-fluoromethoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((7- fluoromethoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((7- fluoromethoxyisoquinolinyl)oxy)-14a-(((1- 30 (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((7- fluoromethoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((7- fluoromethoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((7-fluoro(4-isopropoxyphenyl) 15 methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 20 ((cyclopropylsulfonyl)carbamoyl)((7-fluoro(4-isopropoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((7-fluoro(4- isopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((7-fluoro(4- isopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) 5 ((7-fluoro(4-isopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((7-fluoro(4-isopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((7-fluoro(4-isopropoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((7-fluoro(4-isopropoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((7-fluoro(4-isopropoxyphenyl) 30 methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((7-fluoro(4-isopropoxyphenyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((7-fluoro(4-isopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 2-((7-fluoro(4-isopropoxyphenyl)methoxyisoquinolinyl)oxy)-7,9- 15 dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- 20 ((cyclopropylsulfonyl)carbamoyl)((7-methoxy(4- methoxyphenyl)quinazolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((7-methoxy(4- methoxyphenyl)quinazolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((4-methoxyphthalazinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((4-methoxyphthalazinyl)oxy)-7,9- 5 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((4-methoxyphthalazinyl)oxy)-7,9- 10 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((4-methoxyphthalazinyl)oxy)-7,9- 15 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((4-methoxyphthalazinyl)oxy)-7,9-dimethyl-14a-(((1- 20 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) 25 ((4-methoxyphthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 30 (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)((4- methoxyphthalazinyl)oxy)-7,9-dimethyl-N-((1-methylcyclopropyl)sulfonyl)- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)((4- methoxyphthalazinyl)oxy)-7,9-dimethyl-N-((1-methylcyclopropyl)sulfonyl)- 5 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((4-methoxyphthalazinyl)oxy)-7,9-dimethyl-14a-(((1- 10 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 15 2-((4-methoxyphthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 20 tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((4-methoxyphthalazin yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((4-methoxyphthalazin yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 30 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ethyl((4-methoxyphthalazinyl)oxy)methyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl((4-methoxyphthalazinyl)oxy)methyl-14a-(((1- 5 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)ethyl((4- 10 methoxyphthalazinyl)oxy)methyl-N-((1-methylcyclopropyl)sulfonyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)ethyl((4- 15 methoxyphthalazinyl)oxy)methyl-N-((1-methylcyclopropyl)sulfonyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)ethyl((4- 20 methoxyphthalazinyl)oxy)methyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)ethyl((4- methoxyphthalazinyl)oxy)methyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4- methoxyphthalazinyl)oxy)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((4-ethoxyphthalazin 5 yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((4-ethoxyphthalazin 10 yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) 15 ((4-ethoxyphthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 20 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((4-ethoxyphthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((4-ethoxyphthalazinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((4-ethoxyphthalazinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((4-ethoxyphthalazinyl)oxy)-7,9- 5 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((4-ethoxyphthalazinyl)oxy)-7,9- 10 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)((4-ethoxyphthalazinyl)oxy)-7,9-dimethyl-5,16- 15 dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)((4-ethoxyphthalazinyl)oxy)-7,9-dimethyl-5,16- 20 dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((4-ethoxyphthalazinyl)oxy)ethyl 25 methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((4-ethoxyphthalazinyl)oxy)ethyl 30 methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((4-ethoxyphthalazinyl)oxy)ethyl- 9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((4-ethoxyphthalazinyl)oxy)ethyl- 9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((4-ethoxyphthalazin yl)oxy)ethylmethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((4-ethoxyphthalazin yl)oxy)ethylmethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((4-ethoxyphthalazinyl)oxy)ethylmethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((4-ethoxyphthalazinyl)oxy)ethylmethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((4- ethoxyphthalazinyl)oxy)ethylmethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((4- ethoxyphthalazinyl)oxy)ethylmethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-ethyloxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) 20 ((3-ethyloxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-ethyloxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 2-((3-ethyloxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)((3-ethyl 5 oxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-N-((1- methylcyclopropyl)sulfonyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 10 (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)((3-ethyl oxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-N-((1- methylcyclopropyl)sulfonyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 15 carboxamide; (2R,6S,7R,9S,13aS,14aR,16aS,Z)(4-(dimethylamino)benzamido) ((3-ethyloxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-N-((1- methylcyclopropyl)sulfonyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4-(dimethylamino)benzamido) ((3-ethyloxo-3,4-dihydrophthalazinyl)oxy)-7,9-dimethyl-N-((1- methylcyclopropyl)sulfonyl)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; N1-((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-ethyloxo-3,4- dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- 30 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecinyl)- N2,N2-dimethyloxalamide; 11757-WO-PCT N1-((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-ethyloxo-3,4- dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecinyl)- N2,N2-dimethyloxalamide; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-ethyloxo-3,4- dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-ethyloxo-3,4- dihydrophthalazinyl)oxy)-7,9-dimethyl-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 20 14a-((cyclopropylsulfonyl)carbamoyl)((3-ethyloxo-3,4-dihydrophthalazin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 25 14a-((cyclopropylsulfonyl)carbamoyl)((3-ethyloxo-3,4-dihydrophthalazin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 30 14a-((cyclopropylsulfonyl)carbamoyl)((3-ethyloxo-3,4-dihydrophthalazin- 1-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)((3-ethyloxo-3,4-dihydrophthalazinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 5 carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)((3-ethyloxo-3,4-dihydrophthalazinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 10 carboxamide; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)(4- (dimethylamino)benzamido)((3-ethyloxo-3,4-dihydrophthalazinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 15 carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)(4- (dimethylamino)benzamido)((3-ethyloxo-3,4-dihydrophthalazinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 20 carboxamide; N1-((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-ethyloxo-3,4-dihydrophthalazin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecinyl)- 25 N2,N2-dimethyloxalamide; N1-((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-ethyloxo-3,4-dihydrophthalazin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecinyl)- 30 N2,N2-dimethyloxalamide; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-ethyloxo-3,4-dihydrophthalazinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((1- 5 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4-propoxyisoquinolin yl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((1- 10 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4-propoxyisoquinolin yl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 15 7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 20 7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9- 25 dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9- 30 dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-N-((1- methylcyclopropyl)sulfonyl)-5,16-dioxo((4-propoxyisoquinolinyl)oxy) (3-(1,1,1-trifluoromethylpropanyl)ureido)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-N-((1- methylcyclopropyl)sulfonyl)-5,16-dioxo((4-propoxyisoquinolinyl)oxy) (3-(1,1,1-trifluoromethylpropanyl)ureido)- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((4- 25 propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((4- 30 propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((4- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((4- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate.; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((4- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((4- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((4- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((4- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((4- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((4- 5 propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-7,9-dimethyl- 5,16-dioxo((4-propoxyisoquinolinyl)oxy)(3-(1,1,1-trifluoro 10 methylpropanyl)ureido)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-7,9-dimethyl- 5,16-dioxo((4-propoxyisoquinolinyl)oxy)(3-(1,1,1-trifluoro 15 methylpropanyl)ureido)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- 20 (trideuteromethoxy)isoquinolinyl)oxy)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((1- 25 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- (trideuteromethoxy)isoquinolinyl)oxy)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 30 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- (trideuteromethoxy)isoquinolinyl)oxy)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- 5 (trideuteromethoxy)isoquinolinyl)oxy)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl 10 ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- (trideuteromethoxy)isoquinolinyl)oxy)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- (trideuteromethoxy)isoquinolinyl)oxy)- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-7,9-dimethyl- N-((1-methylcyclopropyl)sulfonyl)-5,16-dioxo((4- 25 (trideuteromethoxy)isoquinolinyl)oxy)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-7,9-dimethyl- 30 N-((1-methylcyclopropyl)sulfonyl)-5,16-dioxo((4- (trideuteromethoxy)isoquinolinyl)oxy)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- 5 (trideuteromethoxy)isoquinolinyl)oxy)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9- 10 dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- (trideuteromethoxy)isoquinolinyl)oxy)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 15 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aR,14aR,16aS)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- (trideuteromethoxy)isoquinolin yl)oxy)octadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 20 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aR,14aR,16aS)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo((4- (trideuteromethoxy)isoquinolin yl)oxy)octadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((4- ethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((4- ethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aR,14aR,16aS)-14a- 5 (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aR,14aR,16aS)-14a- (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((4-methoxyisoquinolin 10 yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; (2R,6S,7R,9R,13aR,14aR,16aS)(3-(tert-butyl)ureido)-N-((1- (fluoromethyl)cyclopropyl)sulfonyl)((4-methoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2- 15 a][1,4]diazacyclopentadecine-14a-carboxamide; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)((5-morpholinoisoquinolinyl)oxy)- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)((5-morpholinoisoquinolinyl)oxy)- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)((5- morpholinoisoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 30 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)((5- 11757-WO-PCT morpholinoisoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 5 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)((5- morpholinoisoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)((5- morpholinoisoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-ethoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-ethoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-ethoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 30 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-ethoxyisoquinolinyl)oxy)-7,9- 11757-WO-PCT dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 5 14a-((cyclopropylsulfonyl)carbamoyl)((6-ethoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 10 14a-((cyclopropylsulfonyl)carbamoyl)((6-ethoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6-ethoxyisoquinolin 15 yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6-ethoxyisoquinolin 20 yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) 25 ((6-ethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 30 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((6-ethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((6-ethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 5 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 10 2-((6-ethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 15 (1-methylcyclopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6- ethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6- ethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6- ethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6- ethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)((6-ethoxyisoquinolinyl)oxy)-7,9- dimethyl-N-((1-methylcyclopropyl)sulfonyl)-5,16-dioxo(3-(1,1,1-trifluoro methylpropanyl)ureido)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 10 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)((6-ethoxyisoquinolinyl)oxy)-7,9- dimethyl-N-((1-methylcyclopropyl)sulfonyl)-5,16-dioxo(3-(1,1,1-trifluoro methylpropanyl)ureido)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-isopropoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-isopropoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-isopropoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 30 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-isopropoxyisoquinolinyl)oxy)- 11757-WO-PCT 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- 5 ((cyclopropylsulfonyl)carbamoyl)((6-isopropoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 10 ((cyclopropylsulfonyl)carbamoyl)((6-isopropoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 15 ((cyclopropylsulfonyl)carbamoyl)((6-isopropoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeuteromethylpropanyl 20 ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)((6- isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 1,1,1,3,3,3-hexadeuteromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)((6- isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 1,1,1,3,3,3-hexadeutero(trideuteromethyl)propanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)((6- isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trideuteromethyl)propanyl 5 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)((6- isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6- isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6- isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((6-isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((6-isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 30 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6- isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6- isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((6-isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 20 2-((6-isopropoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 1,1,1,3,3,3-hexachloromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6-isopropoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 1,1,1,3,3,3-hexachloromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6-isopropoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trideuteromethyl)propanyl 5 ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6-isopropoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 1,1,1,3,3,3-hexadeutero(trideuteromethyl)propanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6-isopropoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((6- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((6- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((6- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo((6- propoxyisoquinolinyl)oxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexachloro(trifluoromethyl)propanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- 5 dimethyl-5,16-dioxo((6-propoxyisoquinolinyl)oxy)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexachloro(trifluoromethyl)propanyl 10 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- dimethyl-5,16-dioxo((6-propoxyisoquinolinyl)oxy)- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 15 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6-methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6-methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeuteromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((6-methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 1,1,1,3,3,3-hexadeuteromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((6-methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)((6- methoxyisoquinolinyl)oxy)-7,9-dimethyl-N-((1-methylcyclopropyl)sulfonyl)- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 10 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)((6- methoxyisoquinolinyl)oxy)-7,9-dimethyl-N-((1-methylcyclopropyl)sulfonyl)- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9S,13aS,14aR,16aS,Z)(4-(dimethylamino)benzamido) ((6-methoxyisoquinolinyl)oxy)-7,9-dimethyl-N-((1- methylcyclopropyl)sulfonyl)-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4-(dimethylamino)benzamido) ((6-methoxyisoquinolinyl)oxy)-7,9-dimethyl-N-((1- 25 methylcyclopropyl)sulfonyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- 30 ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo(phenanthridin yloxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo(phenanthridin yloxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo (phenanthridinyloxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo (phenanthridinyloxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxyphenylisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxyphenylisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-methoxyphenylisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-methoxyphenylisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-methoxyphenylisoquinolin 5 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-methoxyphenylisoquinolin 10 yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((6-methoxy(4- 15 morpholinophenyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 20 ((cyclopropylsulfonyl)carbamoyl)((6-methoxy(4- morpholinophenyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-methoxy(4- morpholinophenyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-methoxy(4- morpholinophenyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 5 14a-((cyclopropylsulfonyl)carbamoyl)((6-methoxy(4- morpholinophenyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((6-methoxy(4- morpholinophenyl)isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((6-methoxy(4-morpholinophenyl)isoquinolinyl)oxy)-7,9-dimethyl-14a- (((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((6-methoxy(4-morpholinophenyl)isoquinolinyl)oxy)-7,9-dimethyl-14a- (((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(5-isopropoxypyridinyl) 30 methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(5-isopropoxypyridinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(5-isopropoxypyridinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(5-isopropoxypyridinyl) 15 methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl 20 ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)((3- (5-isopropoxypyridinyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)((3- (5-isopropoxypyridinyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(5-isopropoxypyridinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 5 ((cyclopropylsulfonyl)carbamoyl)((3-(5-isopropoxypyridinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(5-isopropoxypyridinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(5-isopropoxypyridinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)((3-(5-isopropoxypyridinyl)methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)((3-(5-isopropoxypyridinyl)methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 30 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(6-isopropoxypyridinyl) 11757-WO-PCT methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 5 tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(6-isopropoxypyridinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(6-isopropoxypyridinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(6-isopropoxypyridinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)((3- 25 (6-isopropoxypyridinyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl 30 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)((3- (6-isopropoxypyridinyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16- dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(6-isopropoxypyridinyl) 5 methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 10 14a-((cyclopropylsulfonyl)carbamoyl)((3-(6-isopropoxypyridinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 15 (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)((3-(6-isopropoxypyridinyl)methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 20 (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)((3-(6-isopropoxypyridinyl)methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 25 tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(6-isopropoxypyridin- 3-yl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-(6-isopropoxypyridin- 3-yl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) 5 ((3-(6-isopropoxypyridinyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl- 14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3-(6-isopropoxypyridinyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl- 14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(6-isopropoxypyridinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-(6-isopropoxypyridinyl) 25 methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 30 (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-(6-isopropoxypyridinyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl- 14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 2-((3-(6-isopropoxypyridinyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl- 5 14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)((3-(6- 10 isopropoxypyridinyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-N-((1- methylcyclopropyl)sulfonyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 15 (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)((3-(6- isopropoxypyridinyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-N-((1- methylcyclopropyl)sulfonyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 20 carboxamide; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(2,3- dihydrobenzo[b][1,4]dioxinyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl- 14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-(2,3- dihydrobenzo[b][1,4]dioxinyl)methoxyisoquinolinyl)oxy)-7,9-dimethyl- 14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-(2,3-dihydrobenzo[b][1,4]dioxinyl)methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3-(2,3-dihydrobenzo[b][1,4]dioxinyl)methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3- (2,3-dihydrobenzo[b][1,4]dioxinyl)methoxyisoquinolinyl)oxy)-7,9- 15 dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- 20 (2,3-dihydrobenzo[b][1,4]dioxinyl)methoxyisoquinolinyl)oxy)-7,9- dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(2,3-dihydrobenzo[b][1,4]dioxinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(2,3-dihydrobenzo[b][1,4]dioxinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- 5 ((cyclopropylsulfonyl)carbamoyl)((3-(2,3-dihydrobenzo[b][1,4]dioxinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(2,3-dihydrobenzo[b][1,4]dioxinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(2,3-dihydrobenzo[b][1,4]dioxin yl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-(2,3-dihydrobenzo[b][1,4]dioxin yl)methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((2,3-dihydro- [1,4]dioxino[2,3-f]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 30 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((2,3-dihydro- [1,4]dioxino[2,3-f]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) 20 ((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 2-((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((2,3- dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((2,3- 5 dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((2,3- dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((2,3- dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolin- 7-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolin- 7-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 30 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2,2-difluoro-[1,3]dioxolo[4,5- 11757-WO-PCT f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 5 tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2,2-difluoro-[1,3]dioxolo[4,5- f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3- f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3- f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3- 25 f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3-(trifluoromethyl)pentanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- 30 ((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolin- 7-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 3-(trifluoromethyl)pentanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolin- 7-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3- f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 10 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3- f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 15 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3-methylpentanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolin- 20 7-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3-methylpentanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolin- 25 7-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((2,2-difluoro-[1,3]dioxolo[4,5- 30 f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((2,2-difluoro-[1,3]dioxolo[4,5- f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2,2-difluoro-[1,3]dioxolo[4,5- f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2,2-difluoro-[1,3]dioxolo[4,5- 15 f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1-methylcyclopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- 20 ((cyclopropylsulfonyl)carbamoyl)((2,2-difluoro-[1,3]dioxolo[4,5- f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 (1-methylcyclopropyl)methyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2,2-difluoro-[1,3]dioxolo[4,5- f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((2,2-difluoro-[1,3]dioxolo[4,5- f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 5 14a-((cyclopropylsulfonyl)carbamoyl)((2,2-difluoro-[1,3]dioxolo[4,5- f]isoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl((4-methyl-3,4-dihydro-2H- [1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl((4-methyl-3,4-dihydro-2H- [1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl((4-methyl-3,4-dihydro- 2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl((4-methyl-3,4-dihydro- 30 2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- dimethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- dimethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)- 10 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl((4-methyl-3,4-dihydro-2H- 15 [1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 20 ((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl((4-methyl-3,4-dihydro-2H- [1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)-7,9-dimethyl((4-methyl-3,4-dihydro-2H- [1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 30 carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)-7,9-dimethyl((4-methyl-3,4-dihydro-2H- [1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 1,1,1,3,3,3-hexadeuteromethylpropanyl 5 ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- dimethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 1,1,1,3,3,3-hexadeuteromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- dimethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 1,1,1,3,3,3-hexadeutero(trideuteromethyl)propanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- dimethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)- 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trideuteromethyl)propanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9- dimethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)- 25 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)(4- (dimethylamino)benzamido)-7,9-dimethyl((4-methyl-3,4-dihydro-2H- 30 [1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 11757-WO-PCT (2R,6S,7R,9R,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)(4- (dimethylamino)benzamido)-7,9-dimethyl((4-methyl-3,4-dihydro-2H- [1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl((4-methyl-3,4-dihydro- 2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl((4-methyl-3,4-dihydro- 15 2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl((4-methyl- 20 3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl((4-methyl- 3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 7,9-dimethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolin yl)oxy)-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 5 7,9-dimethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolin yl)oxy)-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl((4-methyl-3,4-dihydro-2H- [1,4]oxazino[2,3-f]isoquinolinyl)oxy)-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl((4-methyl-3,4-dihydro-2H- [1,4]oxazino[2,3-f]isoquinolinyl)oxy)-14a-(((1- 20 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 25 7,9-dimethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolin yl)oxy)-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 30 (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 7,9-dimethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolin yl)oxy)-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-7,9-dimethyl ((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-N-((1- 5 methylcyclopropyl)sulfonyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-7,9-dimethyl- 10 2-((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-N-((1- methylcyclopropyl)sulfonyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 15 (2R,6S,7R,9S,13aS,14aR,16aS,Z)(4-(dimethylamino)benzamido)-7,9- dimethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)- N-((1-methylcyclopropyl)sulfonyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- 20 carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4-(dimethylamino)benzamido)-7,9- dimethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)- N-((1-methylcyclopropyl)sulfonyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; N1-((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl((4-methyl-3,4- dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecinyl)- N2,N2-dimethyloxalamide; 11757-WO-PCT N1-((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl((4-methyl-3,4- dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecinyl)- N2,N2-dimethyloxalamide; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)ethylmethyl((4-methyl-3,4-dihydro- 2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)ethylmethyl((4-methyl-3,4-dihydro- 15 2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 20 14a-((cyclopropylsulfonyl)carbamoyl)ethylmethyl((4-methyl-3,4- dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)ethylmethyl((4-methyl-3,4- dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl) ethylmethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolin 11757-WO-PCT yl)oxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1,3,3,3-hexadeutero(trifluoromethyl)propanyl 5 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl) ethylmethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolin yl)oxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)ethylmethyl((4-methyl-3,4- dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; (1R,3r,5S)-bicyclo[3.1.0]hexanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)ethylmethyl((4-methyl-3,4- dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (2R,6S,7R,9S,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)ethylmethyl((4-methyl-3,4-dihydro-2H- [1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; (2R,6S,7R,9R,13aS,14aR,16aS,Z)(3-(tert-butyl)ureido)-N- (cyclopropylsulfonyl)ethylmethyl((4-methyl-3,4-dihydro-2H- 30 [1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a- carboxamide; 11757-WO-PCT N1-((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)ethylmethyl((4-methyl-3,4-dihydro- 2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecinyl)- N2,N2-dimethyloxalamide; N1-((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)ethylmethyl((4-methyl-3,4-dihydro- 2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecinyl)- N2,N2-dimethyloxalamide; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ethyl-14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)methyl((4- 15 methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) 20 ethyl-14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)methyl((4- methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((2,3-dihydro- [1,4]dioxino[2,3-f]isoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) 5 ((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl-14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)methyl((4- methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ethylmethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolin yl)oxy)-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ethylmethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolin yl)oxy)-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ethylmethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolin 30 yl)oxy)-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ethylmethyl((4-methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolin yl)oxy)-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)ethylmethyl((4- methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)ethylmethyl((4- methyl-3,4-dihydro-2H-[1,4]oxazino[2,3-f]isoquinolinyl)oxy)-14a-(((1- 15 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) 20 ((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)ethylmethyl-14a- (((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)ethylmethyl-14a- (((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)ethylmethyl-14a- (((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) 5 ((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)ethylmethyl-14a- (((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolin- 7-yl)oxy)ethylmethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolin- 7-yl)oxy)ethylmethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3- f]isoquinolinyl)oxy)ethylmethyl-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3- 30 f]isoquinolinyl)oxy)ethylmethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((2,3-dihydro- [1,4]dioxino[2,3-f]isoquinolinyl)oxy)ethylmethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((2,3-dihydro- [1,4]dioxino[2,3-f]isoquinolinyl)oxy)ethylmethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolin- 15 7-yl)oxy)ethylmethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) 20 ((2,3-dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-(4-isopropoxyphenyl)- 4,6-dimethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-(4-isopropoxyphenyl)- 4,6-dimethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3- 5 (4-isopropoxyphenyl)-4,6-dimethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a- (((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 10 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- (4-isopropoxyphenyl)-4,6-dimethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a- (((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 15 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-(4-isopropoxyphenyl)-4,6-dimethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a- (((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3-(4-isopropoxyphenyl)-4,6-dimethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a- (((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3- (4-isopropoxyphenyl)-4,6-dimethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a- 30 (((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT (R)-1,1,1-trifluoropropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3- (4-isopropoxyphenyl)-4,6-dimethoxyisoquinolinyl)oxy)-7,9-dimethyl-14a- (((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)ethyl((3-methoxyisoquinolinyl)oxy) methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 10 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)ethyl((3-methoxyisoquinolin yl)oxy)methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)ethyl((3-methoxyisoquinolin yl)oxy)methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 20 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)ethyl((3- methoxyisoquinolinyl)oxy)methyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 25 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)ethyl((3- methoxyisoquinolinyl)oxy)methyl-14a-(((1- 30 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ethyl((3-methoxyisoquinolinyl)oxy)methyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl((3-methoxyisoquinolinyl)oxy)methyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3-methoxyisoquinolin yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- 15 dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3-methoxyisoquinolin yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- 20 dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-methoxyisoquinolinyl)oxy)-7,9- 25 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-methoxyisoquinolinyl)oxy)-7,9- 30 dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)ethyl-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((3-methoxyisoquinolin yl)oxy)methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)ethyl-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((3-methoxyisoquinolin yl)oxy)methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 10 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3-methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 15 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3-methoxyisoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 20 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((3- 25 methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)- 30 14a-((cyclopropylsulfonyl)carbamoyl)((3-methoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)((3-methoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3,4-dihydro-2H- pyrano[3,2-c]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 10 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3,4-dihydro-2H- pyrano[3,2-c]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 15 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3,4-dihydro-2H-pyrano[3,2-c]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- 20 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) 25 ((3,4-dihydro-2H-pyrano[3,2-c]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 30 tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3,4-dihydro-2H- pyrano[3,2-c]isoquinolinyl)oxy)ethylmethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 11757-WO-PCT hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3,4-dihydro-2H- pyrano[3,2-c]isoquinolinyl)oxy)ethylmethyl-14a-(((1- 5 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3,4-dihydro-2H- 10 pyrano[3,2-c]isoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 15 tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((3,4-dihydro-2H- pyrano[3,2-c]isoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 20 yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3,4-dihydro-2H-pyrano[3,2-c]isoquinolinyl)oxy)ethylmethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 25 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3,4-dihydro-2H-pyrano[3,2-c]isoquinolinyl)oxy)ethylmethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 11757-WO-PCT 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3,4-dihydro-2H-pyrano[3,2-c]isoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- 5 hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3,4-dihydro-2H-pyrano[3,2-c]isoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 10 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3,4-dihydro-2H-pyrano[3,2-c]isoquinolinyl)oxy)-14a-(((1- 15 (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) 20 ((3,4-dihydro-2H-pyrano[3,2-c]isoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 25 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z) ((3,4-dihydro-2H-pyrano[3,2-c]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 30 yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3,4-dihydro-2H-pyrano[3,2-c]isoquinolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- 5 ((cyclopropylsulfonyl)carbamoyl)((3-methoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 10 ((cyclopropylsulfonyl)carbamoyl)((3-methoxyisoquinolinyl)oxy)-7,9- dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- 15 (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((3-methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; and 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- 20 (((1-(fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((3-methoxyisoquinolin yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin yl)carbamate; or a pharmaceutically acceptable salt thereof.
  14. 14. A compound of claim 1, selected from 11757-WO-PCT F D N F D F H H O N O N F O 11757-WO-PCT 11757-WO-PCT H H O CF O CF O N H H H H O N H H CF O CF O H OO CF O CF O 11757-WO-PCT N H H CF O CF O N H H O O N CF O CF O 11757-WO-PCT OO OO H H H H O N O N CF O CF O H H H H O N O N OO OO H H H H O N O N CF O CF O Cl O Cl O Cl O H H H H O N O N CF O CF O 11757-WO-PCT Cl O Cl O CF O Cl O Cl O N H H CF O 11757-WO-PCT 11757-WO-PCT 11757-WO-PCT O O O O H H H H O N O N O CF O ; ;and CF O or a pharmaceutically acceptable salt thereof.
  15. 15. A compound of claim 1, selected from: 11757-WO-PCT 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)ethyl(4-methoxyisoquinolinyloxy)- 9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 5 ylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl(7-fluoromethoxyisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 10 a][1,4]diazacyclopentadecinylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl(7-fluoromethoxyisoquinolinyloxy)methyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 15 a][1,4]diazacyclopentadecinylcarbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)((3-(5-isopropoxypyridinyl) methoxyisoquinolinyl)oxy)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 20 a][1,4]diazacyclopentadecinyl)carbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)((6-methoxyisoquinolinyl)oxy)- 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin 25 yl)carbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4- ethoxymethoxyisoquinolinyloxy)-14a-(1- (fluoromethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- 30 a][1,4]diazacyclopentadecinylcarbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((7- fluoromethoxyisoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 11757-WO-PCT 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z) ((3,6-dimethoxyisoquinolinyl)oxy)ethylmethyl-14a-(((1- 5 methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl(7-methoxyquinoxalinyloxy)methyl-14a-(1- 10 methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinylcarbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)((3- (2,3-dihydrobenzo[b][1,4]dioxinyl)methoxyisoquinolinyl)oxy)-7,9- 15 dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl(7-fluoromethoxyisoquinolinyloxy)-14a-(1- 20 (fluoromethyl)cyclopropylsulfonylcarbamoyl)methyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinylcarbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (1-(fluoromethyl)cyclopropylsulfonylcarbamoyl)(6-methoxyisoquinolinyloxy)- 25 7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a- hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecinylcarbamate; 1,1,1-trifluoromethylpropanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((2- (4-isopropoxyphenyl)methoxyquinazolinyl)oxy)-7,9-dimethyl-14a-(((1- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 30 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z) ethyl(7-fluoro-4,6-dimethoxyisoquinolinyloxy)methyl-14a-(1- 11757-WO-PCT methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinylcarbamate; 3,3-difluoromethylbutanyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)((2,3- 5 dihydro-[1,4]dioxino[2,3-f]isoquinolinyl)oxy)-14a-(((1- (fluoromethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinyl)carbamate; 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(4- 10 ethoxymethoxyisoquinolinyloxy)ethylmethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinylcarbamate; and 1,1,1-trifluoromethylpropanyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)(2- 15 (4-isopropoxyphenyl)methoxyquinolinyloxy)-7,9-dimethyl-14a-(1- methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2- a][1,4]diazacyclopentadecinylcarbamate; or a pharmaceutically acceptable salt thereof.
  16. 16. A composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
  17. 17. The composition of claim 16 further comprising at least one additional 25 compound having anti-HCV activity.
  18. 18. The composition of claim 17 wherein at least one of the additional compounds is an interferon or a ribavirin. 30
  19. 19. The composition of claim 18 wherein the interferon is selected from interferon alpha 2B, pegylated interferon alpha, consensus interferon, interferon alpha 2A, and lymphoblastoid interferon tau. 11757-WO-PCT
  20. 20. The composition of claim 17 wherein at least one of the additional compounds is selected from interleukin 2, interleukin 6, interleukin 12, Imiquimod, ribavirin, an inosine 5'-monophosphate dehydrogenase inhibitor, amantadine, and rimantadine.
  21. 21. The composition of claim 17 wherein at least one of the additional compounds is effective to inhibit the function of a target selected from HCV metalloprotease, HCV serine protease, HCV polymerase, HCV helicase, HCV NS4B protein, HCV entry, HCV assembly, HCV egress, HCV NS5A protein, and IMPDH 10 for the treatment of an HCV infection.
  22. 22. The use of a compound of any one of claims 1 to 15 in the preparation of a medicament for treating an HCV infection in a patient. 15
  23. 23. The use of claim 22, further comprising use of at least one additional compound having anti-HCV activity, wherein the additional compounds are for adminstration prior to, after, or simultaneously with the compound of formula (I), or a pharmaceutically acceptable salt thereof. 20
  24. 24. The use of claim 23 wherein at least one of the additional compounds is an interferon or a ribavirin.
  25. 25. The use of claim 24 wherein the interferon is selected from interferon alpha 2B, pegylated interferon alpha, consensus interferon, interferon alpha 2A, and 25 lymphoblastoid interferon tau.
  26. 26. The use of claim 23 wherein at least one of the additional compounds is selected from interleukin 2, interleukin 6, interleukin 12, Imiquimod, ribavirin, an inosine 5'-monophosphate dehydrogenase inhibitor, amantadine, and rimantadine.
  27. 27. The use of claim 23 wherein at least one of the additional compounds is effective to inhibit the function of a target selected from HCV metalloprotease, HCV serine protease, HCV polymerase, HCV helicase, HCV NS4B protein, HCV entry, 11757-WO-PCT HCV assembly, HCV egress, HCV NS5A protein, and IMPDH for the treatment of an HCV infection.
  28. 28. A composition according to claim 16 substantially as herein described with 5 reference to any example thereof.
NZ618594A 2011-05-05 2012-05-01 Hepatitis c virus inhibitors NZ618594B2 (en)

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US201161482658P 2011-05-05 2011-05-05
US61/482,658 2011-05-05
US201261611171P 2012-03-15 2012-03-15
US61/611,171 2012-03-15
US13/459,403 2012-04-30
US13/459,403 US8957203B2 (en) 2011-05-05 2012-04-30 Hepatitis C virus inhibitors
PCT/US2012/035974 WO2012151195A1 (en) 2011-05-05 2012-05-01 Hepatitis c virus inhibitors

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