NZ617827B2 - Active compound combinations comprising a (thio)carboxamide derivative and a fungicidal compound - Google Patents
Active compound combinations comprising a (thio)carboxamide derivative and a fungicidal compound Download PDFInfo
- Publication number
- NZ617827B2 NZ617827B2 NZ617827A NZ61782712A NZ617827B2 NZ 617827 B2 NZ617827 B2 NZ 617827B2 NZ 617827 A NZ617827 A NZ 617827A NZ 61782712 A NZ61782712 A NZ 61782712A NZ 617827 B2 NZ617827 B2 NZ 617827B2
- Authority
- NZ
- New Zealand
- Prior art keywords
- methyl
- plants
- compound
- difluoromethyl
- found
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 403
- 230000000855 fungicidal Effects 0.000 title claims abstract description 29
- 230000001721 combination Effects 0.000 title description 82
- CYEBJEDOHLIWNP-UHFFFAOYSA-N methanethioamide Chemical class NC=S CYEBJEDOHLIWNP-UHFFFAOYSA-N 0.000 title description 2
- -1 N-cyclopropyl-N-[substituted-benzyl]-3-(difluoromethyl)-5-fluoro-l-methyl-1H-pyrazole-4-carboxamide Chemical class 0.000 claims abstract description 300
- 239000000203 mixture Substances 0.000 claims abstract description 260
- 241000233866 Fungi Species 0.000 claims abstract description 43
- 230000003032 phytopathogenic Effects 0.000 claims abstract description 30
- 230000001276 controlling effect Effects 0.000 claims abstract description 17
- 150000003839 salts Chemical class 0.000 claims description 80
- 239000011780 sodium chloride Substances 0.000 claims description 76
- 239000004009 herbicide Substances 0.000 claims description 63
- XTDZGXBTXBEZDN-UHFFFAOYSA-N 3-(difluoromethyl)-N-(9-isopropyl-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl)-1-methylpyrazole-4-carboxamide Chemical compound CC(C)C1C2CCC1C1=C2C=CC=C1NC(=O)C1=CN(C)N=C1C(F)F XTDZGXBTXBEZDN-UHFFFAOYSA-N 0.000 claims description 61
- 239000005799 Isopyrazam Substances 0.000 claims description 61
- 230000002363 herbicidal Effects 0.000 claims description 61
- 230000000749 insecticidal Effects 0.000 claims description 23
- HKIOYBQGHSTUDB-UHFFFAOYSA-N folpet Chemical compound C1=CC=C2C(=O)N(SC(Cl)(Cl)Cl)C(=O)C2=C1 HKIOYBQGHSTUDB-UHFFFAOYSA-N 0.000 claims description 21
- CRQQGFGUEAVUIL-UHFFFAOYSA-N Chlorothalonil Chemical compound ClC1=C(Cl)C(C#N)=C(Cl)C(C#N)=C1Cl CRQQGFGUEAVUIL-UHFFFAOYSA-N 0.000 claims description 19
- CHNQZRKUZPNOOH-UHFFFAOYSA-J zinc;manganese(2+);N-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[Zn+2].[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S CHNQZRKUZPNOOH-UHFFFAOYSA-J 0.000 claims description 19
- ZQEIXNIJLIKNTD-GFCCVEGCSA-N metalaxyl-M Chemical compound COCC(=O)N([C@H](C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-GFCCVEGCSA-N 0.000 claims description 18
- 239000005738 Bixafen Substances 0.000 claims description 16
- LDLMOOXUCMHBMZ-UHFFFAOYSA-N bixafen Chemical compound FC(F)C1=NN(C)C=C1C(=O)NC1=CC=C(F)C=C1C1=CC=C(Cl)C(Cl)=C1 LDLMOOXUCMHBMZ-UHFFFAOYSA-N 0.000 claims description 16
- MNHVNIJQQRJYDH-UHFFFAOYSA-N 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-1,2,4-triazole-3-thione Chemical compound N1=CNC(=S)N1CC(C1(Cl)CC1)(O)CC1=CC=CC=C1Cl MNHVNIJQQRJYDH-UHFFFAOYSA-N 0.000 claims description 15
- 239000005784 Fluoxastrobin Substances 0.000 claims description 15
- 239000005788 Fluxapyroxad Substances 0.000 claims description 15
- SXSGXWCSHSVPGB-UHFFFAOYSA-N Fluxapyroxad Chemical compound FC(F)C1=NN(C)C=C1C(=O)NC1=CC=CC=C1C1=CC(F)=C(F)C(F)=C1 SXSGXWCSHSVPGB-UHFFFAOYSA-N 0.000 claims description 15
- 239000005825 Prothioconazole Substances 0.000 claims description 15
- 239000005839 Tebuconazole Substances 0.000 claims description 15
- PXMNMQRDXWABCY-UHFFFAOYSA-N Tebuconazole Chemical compound C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 claims description 15
- UFEODZBUAFNAEU-NLRVBDNBSA-N fluoxastrobin Chemical compound C=1C=CC=C(OC=2C(=C(OC=3C(=CC=CC=3)Cl)N=CN=2)F)C=1C(=N/OC)\C1=NOCCO1 UFEODZBUAFNAEU-NLRVBDNBSA-N 0.000 claims description 15
- PFFIDZXUXFLSSR-UHFFFAOYSA-N 1-methyl-N-[2-(4-methylpentan-2-yl)-3-thienyl]-3-(trifluoromethyl)pyrazole-4-carboxamide Chemical compound S1C=CC(NC(=O)C=2C(=NN(C)C=2)C(F)(F)F)=C1C(C)CC(C)C PFFIDZXUXFLSSR-UHFFFAOYSA-N 0.000 claims description 14
- UFNOUKDBUJZYDE-UHFFFAOYSA-N 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Chemical compound C1=NC=NN1CC(O)(C=1C=CC(Cl)=CC=1)C(C)C1CC1 UFNOUKDBUJZYDE-UHFFFAOYSA-N 0.000 claims description 14
- GOFJDXZZHFNFLV-UHFFFAOYSA-N 5-fluoro-1,3-dimethyl-N-[2-(4-methylpentan-2-yl)phenyl]pyrazole-4-carboxamide Chemical compound CC(C)CC(C)C1=CC=CC=C1NC(=O)C1=C(F)N(C)N=C1C GOFJDXZZHFNFLV-UHFFFAOYSA-N 0.000 claims description 14
- 239000005757 Cyproconazole Substances 0.000 claims description 14
- 239000005781 Fludioxonil Substances 0.000 claims description 14
- 239000005789 Folpet Substances 0.000 claims description 14
- 239000005802 Mancozeb Substances 0.000 claims description 14
- 239000005815 Penflufen Substances 0.000 claims description 14
- 239000005816 Penthiopyrad Substances 0.000 claims description 14
- 239000005822 Propiconazole Substances 0.000 claims description 14
- STJLVHWMYQXCPB-UHFFFAOYSA-N Propiconazole Chemical compound O1C(CCC)COC1(C=1C(=CC(Cl)=CC=1)Cl)CN1N=CN=C1 STJLVHWMYQXCPB-UHFFFAOYSA-N 0.000 claims description 14
- 239000005823 Propineb Substances 0.000 claims description 14
- 239000005857 Trifloxystrobin Substances 0.000 claims description 14
- MUJOIMFVNIBMKC-UHFFFAOYSA-N fludioxonil Chemical compound C=12OC(F)(F)OC2=CC=CC=1C1=CNC=C1C#N MUJOIMFVNIBMKC-UHFFFAOYSA-N 0.000 claims description 14
- 239000000417 fungicide Substances 0.000 claims description 14
- ONCZDRURRATYFI-QTCHDTBASA-N methyl (2Z)-2-methoxyimino-2-[2-[[(E)-1-[3-(trifluoromethyl)phenyl]ethylideneamino]oxymethyl]phenyl]acetate Chemical compound CO\N=C(/C(=O)OC)C1=CC=CC=C1CO\N=C(/C)C1=CC=CC(C(F)(F)F)=C1 ONCZDRURRATYFI-QTCHDTBASA-N 0.000 claims description 14
- KKMLIVYBGSAJPM-UHFFFAOYSA-L propineb Chemical compound [Zn+2].[S-]C(=S)NC(C)CNC([S-])=S KKMLIVYBGSAJPM-UHFFFAOYSA-L 0.000 claims description 14
- 239000005730 Azoxystrobin Substances 0.000 claims description 13
- WFDXOXNFNRHQEC-GHRIWEEISA-N Azoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1OC1=CC(OC=2C(=CC=CC=2)C#N)=NC=N1 WFDXOXNFNRHQEC-GHRIWEEISA-N 0.000 claims description 13
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- XQJQCBDIXRIYRP-UHFFFAOYSA-N N-{2-[1,1'-bi(cyclopropyl)-2-yl]phenyl}-3-(difluoromethyl)-1-methyl-1pyrazole-4-carboxamide Chemical compound FC(F)C1=NN(C)C=C1C(=O)NC1=CC=CC=C1C1C(C2CC2)C1 XQJQCBDIXRIYRP-UHFFFAOYSA-N 0.000 claims description 13
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- PUYXTUJWRLOUCW-UHFFFAOYSA-N spiroxamine Chemical compound O1C(CN(CC)CCC)COC11CCC(C(C)(C)C)CC1 PUYXTUJWRLOUCW-UHFFFAOYSA-N 0.000 claims description 13
- ZMYFCFLJBGAQRS-IRXDYDNUSA-N (2R,3S)-epoxiconazole Chemical compound C1=CC(F)=CC=C1[C@@]1(CN2N=CN=C2)[C@H](C=2C(=CC=CC=2)Cl)O1 ZMYFCFLJBGAQRS-IRXDYDNUSA-N 0.000 claims description 12
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- OIPMQULDKWSNGX-UHFFFAOYSA-N bis[[ethoxy(oxo)phosphaniumyl]oxy]alumanyloxy-ethoxy-oxophosphanium Chemical compound [Al+3].CCO[P+]([O-])=O.CCO[P+]([O-])=O.CCO[P+]([O-])=O OIPMQULDKWSNGX-UHFFFAOYSA-N 0.000 claims description 12
- 239000004094 surface-active agent Substances 0.000 claims description 12
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 12
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- GBOYJIHYACSLGN-UHFFFAOYSA-N Fluopicolide Chemical compound ClC1=CC(C(F)(F)F)=CN=C1CNC(=O)C1=C(Cl)C=CC=C1Cl GBOYJIHYACSLGN-UHFFFAOYSA-N 0.000 claims description 11
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
- A01N59/20—Copper
Abstract
Disclosed are fungicidal compositions, which comprises (A) a N-cyclopropyl-N-[substituted-benzyl]-3-(difluoromethyl)-5-fluoro-l-methyl-1H-pyrazole-4-carboxamide or thiocarboxamide derivative of formula (I) and a further fungicidally active compound (B). Also disclosed is a method for controlling the phytopathogenic fungi of plants or crops and the use of the composition for the treatment of seed. Examples of the compounds of formula (I) are: N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carbothioamide N-[2-chloro-6-(trifluoromethyl)benzy 1]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide N-(2-tert-butyl-5-methylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide phytopathogenic fungi of plants or crops and the use of the composition for the treatment of seed. Examples of the compounds of formula (I) are: N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carbothioamide N-[2-chloro-6-(trifluoromethyl)benzy 1]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide N-(2-tert-butyl-5-methylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide
Description
Active compound combinations comprising a (thio)carboxamide derivative
and a fungicidal compound
The present invention relates generally to active compound combinations, in particular within a fungicide
composition, which comprises (A) a N-cyclopropyl-N-[substituted-benzyl](difluoromethyl)fluoro
methyl-1H-pyrazolecarboxamide or thiocarboxamide derivative and a further fungicidally active com-
pound (B). Moreover, the invention relates generally to a method for curatively or preventively or eradica-
tively controlling the phytopathogenic fungi of plants or crops, and to the use of a combination according to
the invention for the treatment of seed. Also described is a method for protecting a seed and a treated seed.
N-cyclopropyl-N-[substituted-benzyl]-carboxamides or thiocarboxamides, their preparation from commer-
cially available materials and their use as fungicides are disclosed in WO2007/087906, WO2009/016220
and WO2010/130767.
Since the environmental and economic requirements imposed on modern-day crop protection compositions
are continually increasing, with regard, for example, to the spectrum of action, toxicity, selectivity, applica-
tion rate, formation of residues, and favourable preparation ability, and since, furthermore, there may be
problems, for example, with resistances, a constant task is to develop new compositions, in particular fungi-
cidal agents, which in some areas at least help to fulfil the abovementioned requirements.
The present invention provides active compound combinations/compositions which in some aspects at least
achieve the stated objective; and/or at least provide the public with a useful choice.
It has now been found, surprisingly, that the combinations described herein not only bring about the additive
enhancement of the spectrum of action with respect to the phytopathogen to be controlled that was in principle
to be expected but achieves a synergistic effect which extends the range of action of the component (A) and of
the component (B) in two ways. Firstly, the rates of application of the component (A) and of the component
(B) are lowered whilst the action remains equally good. Secondly, the combination still achieves a high degree
of phytopathogen control even where the two individual compounds have become totally ineffective in such a
low application rate range. This allows, on the one hand, a substantial broadening of the spectrum of phytopa-
thogens that can be controlled and, on the other hand, increased safety in use.
In addition to the fungicidal synergistic activity, the active compound combinations described herein have fur-
ther surprising properties which, in a wider sense, may also be called synergistic, such as, for example: broad-
ening of the activity spectrum to other phytopathogens, for example to resistant strains of plant diseases; lower
application rates of the active compounds; sufficient control of pests with the aid of the active compound com-
binations even at application rates where the individual compounds show no or virtually no activity; advanta-
geous behaviour during formulation or during use, for example during grinding, sieving, emulsifying, dissolv-
ing or dispensing; improved storage stability and light stability; advantageous residue formation; improved
toxicological or ecotoxicological behaviour; improved properties of the plant, for example better growth, in-
creased harvest yields, a better developed root system, a larger leaf area, greener leaves, stronger shoots, less
seed required, lower phytotoxicity, mobilization of the defence system of the plant, good compatibility with
plants. Thus, the use of the active compound combinations described herein or compositions according to the
invention contributes considerably to keeping young cereal stands healthy, which increases, for example, the
winter survival of the cereal seed treated, and also safeguards quality and yield. Moreover, the active com-
pound combinations described herein may contribute to enhanced systemic action. Even if the individual com-
pounds of the combination have no sufficient systemic properties, the active compound combinations may still
have this property. In a similar manner, the active compound combinations may result in higher persistency of
the fungicidal action.
Accordingly, in one aspect the present invention provides an active composition comprising
(A) at least one derivative of formula (I)
wherein T represents an oxygen atom and X is selected from the group consisting of 2-isopropyl, 2-
cyclopropyl, 2-tert-butyl, 5-chloroethyl, 5-chloroisopropyl, 2-ethylfluoro, 5-fluoroisopropyl, 2-
cyclopropylfluoro, 2-fluoroisopropyl, 2-ethylmethyl, 2-isopropylmethyl, 2-cyclopropylmethyl,
2-tert-butylmethyl, 5-chloro(trifluoromethyl), 5-methyl(trifluoromethyl), 2-chloro
(trifluoromethyl), 3-chlorofluoro(trifluoromethyl) and 2-ethyl-4,5-dimethyl, or an agrochemically ac-
ceptable salt thereof,
(B) at least one further active fungicidal compound B, selected from the group consisting of:
cyproconazole (1130964), epoxiconazole (1063250), fenhexamid (1268338), metconazole
(1251166), propiconazole (602071), prothioconazole (1789286), spiroxamine (1181348),
tebuconazole (1075343), bixafen (58180903), fluopyram (6580664), isopyrazam (mixture of
syn-epimeric racemate 1RS,4SR,9RS and anti-epimeric racemate 1RS,4SR,9SR) (881651), isopyrazam
(syn epimeric racemate 1RS,4SR,9RS), isopyrazam (syn-epimeric enantiomer 1R,4S,9R), isopyrazam (syn-
epimeric enantiomer 1S,4R,9S), isopyrazam (anti-epimeric racemate 1RS,4SR,9SR), isopyrazam (anti-
epimeric enantiomer 1R,4S,9S), isopyrazam (anti-epimeric enantiomer 1S,4R,9R), penflufen (4947938),
penthiopyrad (1836753), sedaxane (8749676), fluxapyroxad (9072043), benzovindiflupyr, N-
[1-(2,4-dichlorophenyl)methoxypropanyl](difluoromethyl)methyl-1H-pyrazolecarboxamide,
ametoctradin (8653184), azoxystrobin (1318608), fluoxastrobin (3613779), pyraclostrobin
(1750130), trifloxystrobin (1415177), fluopicolide (2391107), chlorothalonil (18976), fol-
pet (1333), mancozeb (80187), propineb (120719), isotianil (2240491), pyrimethanil
(531120), iprovalicarb (1409237), propamocarb (256061), metalaxyl (578371), metalaxyl-
M (mefenoxam) (706300), fludioxonil (1313411),fosetyl-Al (391488), 2,6-dimethyl-1H,5H-
[1,4]dithiino[2,3-c:5,6-c']dipyrrole-1,3,5,7(2H,6H)-tetrone, N'-(4-{[3-(4-chlorobenzyl)-1,2,4-thiadiazol
yl]oxy}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide and salts thereof.
In another aspect, the invention provides a composition for controlling phytopathogenic harmful fungi,
comprising at least one active composition according to the invention, and at least one extender and/or sur-
factant.
In another aspect, the invention provides a process for producing compositions for controlling phytopatho-
genic harmful fungi, wherein an active composition according to the invention is mixed with at least one ex-
tender and/or surfactant.
In another aspect, the invention provides a composition produced by the process according to the invention.
In another aspect, the invention provides a method for controlling phytopathogenic harmful fungi, wherein
an active composition according to the invention is applied to the phytopathogenic harmful fungi and/or
their habitat.
In another aspect, the invention relates to the use of an active composition according to the invention for
control of phytopathogenic harmful fungi.
In another aspect, the invention relates to the use of an active composition according to the invention for the
treatment of transgenic plants.
In another aspect, the invention relates to the use of an active composition according to the invention for the
treatment of seed and of seed of transgenic plants.
Certain statements that appear below are broader than what appears in the statements of the invention
above. These statements are provided in the interests of providing the reader with a better understanding of
the invention and its practice. The reader is directed to the accompanying claim set which defines the scope
of the invention.
Also described is a combination comprising:
(A) at least one derivative of formula (I)
wherein T represents an oxygen or a sulfur atom and X is selected from the list of 2-isopropyl, 2-
cyclopropyl, 2-tert-butyl, 5-chloroethyl, 5-chloroisopropyl, 2-ethylfluoro, 5-fluoroisopropyl, 2-
cyclopropylfluoro, 2-cyclopentylfluoro, 2-fluoroisopropyl, 2-ethylmethyl, 2-isopropylmethyl,
2-cyclopropylmethyl, 2-tert-butylmethyl, 5-chloro(trifluoromethyl), 5-methyl(trifluoromethyl),
2-chloro(trifluoromethyl), 3-chlorofluoro(trifluoromethyl) and 2-ethyl-4,5-dimethyl, or an agro-
chemically acceptable salt thereof,
(B) at least one further active fungicidal compound B.
Preference is given to combinations comprising at least one compound of the formula (I) selected from the
group consisting of :
N-cyclopropyl(difluoromethyl)fluoro-N-(2-isopropylbenzyl)methyl-1H-pyrazolecarboxamide
(compound A1),
N-cyclopropyl-N-(2-cyclopropylbenzyl)(difluoromethyl)fluoromethyl-1H-pyrazolecarboxamide
(compound A2),
N-(2-tert-butylbenzyl)-N-cyclopropyl(difluoromethyl)fluoromethyl-1H-pyrazolecarboxamide
(compound A3),
N-(5-chloroethylbenzyl)-N-cyclopropyl(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide (compound A4),
N-(5-chloroisopropylbenzyl)-N-cyclopropyl(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide (compound A5),
N-cyclopropyl(difluoromethyl)-N-(2-ethylfluorobenzyl)fluoromethyl-1H-pyrazole
carboxamide (compound A6),
N-cyclopropyl(difluoromethyl)fluoro-N-(5-fluoroisopropylbenzyl)methyl-1H-pyrazole
carboxamide (compound A7),
N-cyclopropyl-N-(2-cyclopropylfluorobenzyl)(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide (compound A8),
N-(2-cyclopentylfluorobenzyl)-N-cyclopropyl(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide (compound A9),
N-cyclopropyl(difluoromethyl)fluoro-N-(2-fluoroisopropylbenzyl)methyl-1H-pyrazole
carboxamide (compound A10),
N-cyclopropyl(difluoromethyl)-N-(2-ethylmethylbenzyl)fluoromethyl-1H-pyrazole
carboxamide (compound A11),
N-cyclopropyl(difluoromethyl)fluoro-N-(2-isopropylmethylbenzyl)methyl-1H-pyrazole
carboxamide (compound A12),
N-cyclopropyl-N-(2-cyclopropylmethylbenzyl)(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide (compound A13),
N-(2-tert-butylmethylbenzyl)-N-cyclopropyl(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide (compound A14),
N-[5-chloro(trifluoromethyl)benzyl]-N-cyclopropyl(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide (compound A15),
N-cyclopropyl(difluoromethyl)fluoromethyl-N-[5-methyl(trifluoromethyl)benzyl]-1H-pyrazole-
4-carboxamide (compound A16),
N-[2-chloro(trifluoromethyl)benzyl]-N-cyclopropyl(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide (compound A17),
N-[3-chlorofluoro(trifluoromethyl)benzyl]-N-cyclopropyl(difluoromethyl)fluoromethyl-1H-
pyrazolecarboxamide (compound A18).
N-cyclopropyl(difluoromethyl)-N-(2-ethyl-4,5-dimethylbenzyl)fluoromethyl-1H-pyrazole
carboxamide (compound A19),
and N-cyclopropyl(difluoromethyl)fluoro-N-(2-isopropylbenzyl)methyl-1H-pyrazolecarbothio-
amide (compound A20).
In a particular embodiment, the fungicidal compound B is selected from the following groups:
(1) inhibitors of the ergosterol synthesis,
(2) inhibitors of the respiratory chain at complex I or II,
(3) inhibitors of the respiratory chain at complex III,
(4) inhibitors of the mitosis and cell division,
(5) compounds capable of having a multisite action,
(6) compounds capable of inducing a host defense,
(7) inhibitors of the amino acid and/or protein biosynthesis,
(8) inhibitors of the ATP production,
(9) inhibitors of the cell wall synthesis or glucan Synthesis,
(10) inhibitors of the lipid and membrane synthesis,
(11) inhibitors of the melanine biosynthesis,
(12) inhibitors of the nucleic acid synthesis,
(13) inhibitors of the signal transduction,
(14) compounds capable of acting as uncoupler,
(15) other fungicides
(16) further fungicides
Preference is further given to combinations comprising an inhibitor of the ergosterol synthesis selected from
the group consisting of [Group (1)]:
(1.1) aldimorph (17045), (1.2) azaconazole (602070), (1.3) bitertanol (551792), (1.4) bromuco-
nazole (1162552), (1.5) cyproconazole (1130964), (1.6) diclobutrazole (757363), (1.7) difeno-
conazole (1194463), (1.8) diniconazole (836573), (1.9) diniconazole-M (836575), (1.10) dode-
morph (15937), (1.11) dodemorph acetate (317170), (1.12) epoxiconazole (1063250), (1.13)
etaconazole (602074), (1.14) fenarimol (601689), (1.15) fenbuconazole (1143696), (1.16) fen-
hexamid (1268338), (1.17) fenpropidin (673067), (1.18) fenpropimorph (673060), (1.19) flu-
quinconazole (1364265), (1.20) flurprimidol (564253), (1.21) flusilazole (855099), (1.22) flu-
triafol (766740), (1.23) furconazole (1128395), (1.24) furconazole-cis (1128394), (1.25) hex-
aconazole (799834), (1.26) imazalil (605347), (1.27) imazalil sulfate (585942), (1.28) imiben-
conazole (865987), (1.29) ipconazole (1252257), (1.30) metconazole (1251166), (1.31) myclo-
butanil (886710), (1.32) naftifine (654720), (1.33) nuarimol (632849), (1.34) oxpoconazole
(1742125), (1.35) paclobutrazol (767380), (1.36) pefurazoate (1019034), (1.37) penconazole
(662466), (1.38) piperalin (34782), (1.39) prochloraz (677475), (1.40) propiconazole (60207-
90-1), (1.41) prothioconazole (1789286), (1.42) pyributicarb (886785), (1.43) pyrifenox (88283
4), (1.44) quinconazole (1039708), (1.45) simeconazole (1495087), (1.46) spiroxamine (118134
8), (1.47) tebuconazole (1075343), (1.48) terbinafine (911616), (1.49) tetraconazole (1122813),
(1.50) triadimefon (431213), (1.51) triadimenol (894827), (1.52) tridemorph (814123), (1.53)
triflumizole (686941), (1.54) triforine (266442), (1.55) triticonazole (1319837), (1.56) unicona-
zole (836571), (1.57) uniconazole-p (836574), (1.58) viniconazole (771744), (1.59) voricona-
zole (1372349), (1.60) 1-(4-chlorophenyl)(1H-1,2,4-triazolyl)cycloheptanol (1295869), (1.61)
methyl 1-(2,2-dimethyl-2,3-dihydro-1H-indenyl)-1H-imidazolecarboxylate (1103230), (1.62) N'-
{5-(difluoromethyl)methyl[3-(trimethylsilyl)propoxy]phenyl}-N-ethyl-N-methylimidoformamide,
(1.63) N-ethyl-N-methyl-N'-{2-methyl(trifluoromethyl)[3-
(trimethylsilyl)propoxy]phenyl}imidoformamide and (1.64) O-[1-(4-methoxyphenoxy)-3,3-dimethylbutan-
2-yl] 1H-imidazolecarbothioate (1112262), and salts thereof.
Particular preference is given to combinations comprising an inhibitor of the ergosterol synthesis selected
from the group consisting of cyproconazole (1130964), difenoconazole (1194463), epoxiconazole
(1063250), fenhexamid (1268338), fenpropidin (673067), fenpropimorph (673060), fluquin-
conazole (1364265), hexaconazole (799834), ipconazole (1252257), metconazole (1251166),
myclobutanil (886710), prochloraz (677475), propiconazole (602071), prothioconazole (178928-
70-6), spiroxamine (1181348), tebuconazole (1075343), tetraconazole (1122813) and triadimenol
(894827), and salts thereof.
More particular preference is given to combinations comprising an inhibitor of the ergosterol synthesis se-
lected from the group consisting of cyproconazole (1130964), ), epoxiconazole (1063250), fenhexam-
id (1268338), metconazole (1251166), propiconazole (602071), prothioconazole (1789286),
spiroxamine (1181348) and tebuconazole (1075343), and salts thereof.
Preference is further given to combinations comprising an inhibitor of the respiratory chain at complex I or
II selected from the group consisting of [Group (2)]: (2.1) bixafen (5818093), (2.2) boscalid (188425-
85-6), (2.3) carboxin (52344), (2.4) diflumetorim (1303390), (2.5) fenfuram (246913), (2.6)
fluopyram (6580664), (2.7) flutolanil (663325), (2.8) fluxapyroxad (9072043), (2.9) furametpyr
(1235723), (2.10) furmecyclox (605680), (2.11) isopyrazam (mixture of syn-epimeric racemate
1RS,4SR,9RS and anti-epimeric racemate 1RS,4SR,9SR) (8816851), (2.12) isopyrazam (anti-epimeric
racemate 1RS,4SR,9SR), (2.13) isopyrazam (anti-epimeric enantiomer 1R,4S,9S), (2.14) isopyrazam (anti-
epimeric enantiomer 1S,4R,9R), (2.15) isopyrazam (syn epimeric racemate 1RS,4SR,9RS), (2.16) isopyra-
zam (syn-epimeric enantiomer 1R,4S,9R), (2.17) isopyrazam (syn-epimeric enantiomer 1S,4R,9S), (2.18)
mepronil (558140), (2.19) oxycarboxin (52591), (2.20) penflufen (4947938), (2.21) penthiopy-
rad (1836753), (2.22) sedaxane (8749676), (2.23) thifluzamide (1300007), (2.24) 1-methyl-N-
[2-(1,1,2,2-tetrafluoroethoxy)phenyl](trifluoromethyl)-1H-pyrazolecarboxamide, (2.25) 3-
(difluoromethyl)methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-1H-pyrazolecarboxamide, (2.26) 3-
(difluoromethyl)-N-[4-fluoro(1,1,2,3,3,3-hexafluoropropoxy)phenyl]methyl-1H-pyrazole
carboxamide, (2.27) N-[1-(2,4-dichlorophenyl)methoxypropanyl](difluoromethyl)methyl-1H-
pyrazolecarboxamide (10924007), (2.28) 5,8-difluoro-N-[2-(2-fluoro{[4-(trifluoromethyl)pyridin-
2-yl]oxy}phenyl)ethyl]quinazolinamine (12100700), (2.29) benzovindiflupyr, (2.30) N-[(1S,4R)
(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalenyl](difluoromethyl)methyl-1H-
pyrazolecarboxamide, (2.31) N-[(1R,4S)(dichloromethylene)-1,2,3,4-tetrahydro-1,4-
methanonaphthalenyl](difluoromethyl)methyl-1H-pyrazolecarboxamide, (2.32) 3-
(Difluormethyl)methyl-N-(1,1,3-trimethyl-2,3-dihydro-1H-indenyl)-1H-pyrazolcarboxamide, (2.33)
1,3,5-Trimethyl-N-(1,1,3-trimethyl-2,3-dihydro-1H-indenyl)-1H-pyrazolcarboxamide, (2.34) 1-
Methyl(trifluormethyl)-N-(1,3,3-trimethyl-2,3-dihydro-1H-indenyl)-1H-pyrazolcarboxamide, (2.35)
1-Methyl(trifluormethyl)-N-[(1S)-1,3,3-trimethyl-2,3-dihydro-1H-indenyl]-1H-pyrazol
carboxamide, (2.36) 1-Methyl(trifluormethyl)-N-[(1R)-1,3,3-trimethyl-2,3-dihydro-1H-indenyl]-1H-
pyrazolcarboxamide, (2.37) 3-(Difluormethyl)methyl-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-1H-inden
yl]-1H-pyrazolcarboxamide, (2.38) 3-(Difluormethyl)methyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H-
indenyl]-1H-pyrazolcarboxamide, (2.39) 1,3,5-Trimethyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H-
indenyl]-1H-pyrazolcarboxamide, (2.40) 1,3,5-Trimethyl-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-1H-
indenyl]-1H-pyrazolcarboxamide and (2.41) benodanil (153107), and salts thereof.
Particular preference is given to combinations comprising an inhibitor of the respiratory chain at complex I
or II selected from the group consisting of bixafen (58180903), boscalid (1884256), fluopyram
(6580664), flutolanil (663325), isopyrazam (mixture of syn-epimeric racemate 1RS,4SR,9RS and anti-
epimeric racemate 1RS,4SR,9SR) (881651), isopyrazam (syn epimeric racemate 1RS,4SR,9RS), isopyra-
zam (syn-epimeric enantiomer 1R,4S,9R), isopyrazam (syn-epimeric enantiomer 1S,4R,9S), isopyrazam (anti-
epimeric racemate 1RS,4SR,9SR), isopyrazam (anti-epimeric enantiomer 1R,4S,9S), isopyrazam (anti-
epimeric enantiomer 1S,4R,9R), penflufen (4947938), penthiopyrad (1836753), sedaxane (874967
6), 3-(difluoromethyl)methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-1H-pyrazolecarboxamide, 3-
(difluoromethyl)-N-[4-fluoro(1,1,2,3,3,3-hexafluoropropoxy)phenyl]methyl-1H-pyrazole
carboxamide, fluxapyroxad (9072043), benzovindiflupyr and N-[1-(2,4-dichlorophenyl)
methoxypropanyl](difluoromethyl)methyl-1H-pyrazolecarboxamide, and salts thereof.
More particular preference is given to combinations comprising an inhibitor of the respiratory chain at com-
plex I or II selected from the group consisting of bixafen (58180903), fluopyram (6580664), isopyra-
zam (mixture of syn-epimeric racemate 1RS,4SR,9RS and anti-epimeric racemate 1RS,4SR,9SR) (88165
1), isopyrazam (syn epimeric racemate 1RS,4SR,9RS), isopyrazam (syn-epimeric enantiomer 1R,4S,9R), iso-
pyrazam (syn-epimeric enantiomer 1S,4R,9S), isopyrazam (anti-epimeric racemate 1RS,4SR,9SR), isopyrazam
(anti-epimeric enantiomer 1R,4S,9S), isopyrazam (anti-epimeric enantiomer 1S,4R,9R), penflufen (494793
8), penthiopyrad (1836753), sedaxane (8749676), fluxapyroxad (9072043), benzovindiflupyr and
N-[1-(2,4-dichlorophenyl)methoxypropanyl](difluoromethyl)methyl-1H-pyrazole
carboxamide, and salts thereof.
Preference is further given to combinations comprising an inhibitor of the respiratory chain at complex III
selected from the group consisting of [Group (3)]:
(3.1) ametoctradin (8653184), (3.2) amisulbrom (3486350), (3.3) azoxystrobin (1318608), (3.4)
cyazofamid (1201163), (3.5) coumethoxystrobin (8508810), (3.6) coumoxystrobin (8508818),
(3.7) dimoxystrobin (1416004), (3.8) enestroburin (2384102), (3.9) famoxadone (1318073),
(3.10) fenamidone (1613267), (3.11) fenoxystrobin (9181624), (3.12) fluoxastrobin (3613779),
(3.13) kresoxim-methyl (1433900), (3.14) metominostrobin (1334081), (3.15) orysastrobin
(1898921), (3.16) picoxystrobin (1174285), (3.17) pyraclostrobin (1750130), (3.18) pyrameto-
strobin (9154107), (3.19) pyraoxystrobin (8625882), (3.20) pyribencarb (7992472), (3.21) tric-
lopyricarb (9027601), (3.22) trifloxystrobin (1415177), (3.23) (2E)(2-{[6-(3-chloro
methylphenoxy)fluoropyrimidinyl]oxy}phenyl)(methoxyimino)-N-methylethanamide, (3.24) (2E)-
2-(methoxyimino)-N-methyl(2-{[({(1E)[3-(trifluoromethyl)phenyl]ethylidene}amino)oxy]methyl}-
phenyl)ethanamide, (3.25) (2E)(methoxyimino)-N-methyl{2-[(E)-({1-[3-(trifluoromethyl)phenyl]-
ethoxy}imino)methyl]phenyl}ethanamide (1581694), (3.26) (2E){2-[({[(1E)(3-{[(E)fluoro
phenylethenyl]oxy}phenyl)ethylidene]amino}oxy)methyl]phenyl}(methoxyimino)-N-methylethanamide
(3268960), (3.27) (2E){2-[({[(2E,3E)(2,6-dichlorophenyl)butenylidene]amino}oxy)methyl]-
phenyl}(methoxyimino)-N-methylethanamide, (3.28) 2-chloro-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-
4-yl)pyridinecarboxamide (1198998), (3.29) 5-methoxymethyl(2-{[({(1E)[3-
(trifluoromethyl)phenyl]ethylidene}amino)oxy]methyl}phenyl)-2,4-dihydro-3H-1,2,4-triazolone, (3.30)
methyl (2E){2-[({cyclopropyl[(4-methoxyphenyl)imino]methyl}sulfanyl)methyl]phenyl}
methoxypropenoate (1496016), (3.31) N-(3-ethyl-3,5,5-trimethylcyclohexyl)(formylamino)
hydroxybenzamide (2265519), (3.32) 2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}methoxy-N-
methylacetamide (1736620) and (3.33) (2R){2-[(2,5-dimethylphenoxy)methyl]phenyl}methoxy-
N-methylacetamide (3946570), and salts thereof
Particular preference is given to combinations comprising an inhibitor of the respiratory chain at complex III
selected from the group consisting of ametoctradin (8653184), amisulbrom (3486350), azoxystrobin
(1318608), cyazofamid (1201163), dimoxystrobin (1416004), enestroburin (2384102), fe-
namidone (1613267), fluoxastrobin (3613779), kresoxim-methyl (1433900), metominostrobin
(1334081), orysastrobin (1898921), picoxystrobin (1174285), pyraclostrobin (1750130) and
trifloxystrobin (1415177), and salts thereof.
More particular preference is given to combinations comprising an inhibitor of the respiratory chain at com-
plex III selected from the group consisting of ametoctradin (8653184), azoxystrobin (1318608),
fluoxastrobin (3613779), pyraclostrobin (1750130) and trifloxystrobin (1415177), and salts the-
reof.
Preference is further given to combinations comprising an inhibitor of the mitosis and cell division selected
from the group consisting of [Group (4)]:
(4.1) benomyl (178042), (4.2) carbendazim (106057), (4.3) chlorfenazole (35747), (4.4) dietho-
fencarb (871309), (4.5) ethaboxam (1626503), (4.6) fluopicolide (2391107), (4.7) fuberidazole
(38781), (4.8) pencycuron (660636), (4.9) thiabendazole (1488), (4.10) thiophanate-methyl
(235648), (4.11) thiophanate (235649), (4.12) zoxamide (1560525), (4.13) 5-chloro(4-
methylpiperidinyl)(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine (2147063) and (4.14) 3-
chloro(6-chloropyridinyl)methyl(2,4,6-trifluorophenyl)pyridazine (10027567), and salts
thereof.
Particular preference is given to combinations comprising an inhibitor of the mitosis and cell division se-
lected from the group consisting of pencycuron (660636), thiophanate-methyl (235648), fluopico-
lide (2391107) and thiophanate (235649), and salts thereof.
More particular preference is given to combinations comprising an inhibitor of the mitosis and cell division
selected from the group consisting of fluopicolide (2391107) and salts thereof.
Preference is further given to combinations comprising a compound capable of having a multisite action se-
lected from the group consisting of [Group (5)]:
(5.1) bordeaux mixture (80110), (5.2) captafol (24251), (5.3) captan (1332), (5.4) chlorothalonil
(18976), (5.5) copper hydroxide (204272), (5.6) copper naphthenate (13389), (5.7) copper oxide
(13171), (5.8) copper oxychloride (13327), (5.9) copper(2+) sulfate (77587), (5.10) dichloflua-
nid (10859), (5.11) dithianon (33476), (5.12) dodine (24393), (5.13) dodine free base, (5.14)
ferbam (144841), (5.15) fluorofolpet (7190), (5.16) folpet (1333), (5.17) guazatine (108173
6), (5.18) guazatine acetate, (5.19) iminoctadine (135163), (5.20) iminoctadine albesilate (169202
6), (5.21) iminoctadine triacetate (575209), (5.22) mancopper (539885), (5.23) mancozeb (8018
7), (5.24) maneb (124272), (5.25) metiram (90062), (5.26) metiram zinc (90062), (5.27) oxine-
copper (103806), (5.28) propamidine (1045), (5.29) propineb (120719), (5.30) sulfur and sulfur
preparations including calcium polysulfide (77049), (5.31) thiram (1378), (5.32) tolylfluanid (731-
27-1), (5.33) zineb (121227), (5.34) ziram (1374) and (5.35) anilazine (1013), and salts thereof.
Particular preference is given to combinations comprising a compound capable of having a multisite action
selected from the group consisting of bordeaux mixture (80110), chlorothalonil (18976), dithianon
(33476), dodine (24393), folpet (1333), guazatine (1081736), copper oxide (13171), cop-
per oxychloride (13327), copper hydroxide (204272), copper sulfate (77587), mancozeb (8018
7), maneb (124272), oxine-copper (103806), propineb (120719), sulfur and sulfur preparations in-
cluding calcium polysulfide (77049), thiram (1378) and copper naphthenate (13389), and salts the-
reof.
More particular preference is given to combinations comprising a compound capable of having a multisite
action selected from the group consisting of chlorothalonil (18976), folpet (1333), mancozeb (8018-
01-7) and propineb (120719), and salts thereof.
Preference is further given to combinations comprising a compound capable of inducing a host defense se-
lected from the group consisting of [Group (6)]:
(6.1) acibenzolar-S-methyl (1351582), (6.2) isotianil (2240491), (6.3) probenazole (276051),
(6.4) tiadinil (2235806) and (6.5) laminarin (90084), and salts thereof.
More particular preference is given to combinations comprising a compound capable of inducing a host de-
fense selected from the group consisting of isotianil (2240491)and salts thereof..
Preference is further given to combinations comprising an inhibitor of the amino acid and/or protein biosyn-
thesis selected from the group consisting of [Group (7)]:
(7.1) andoprim (239511), (7.2) blasticidin-S (20797), (7.3) cyprodinil (1215522), (7.4) kasuga-
mycin (69803), (7.5) kasugamycin hydrochloride hydrate (194089), (7.6) mepanipyrim (110235
7), (7.7) pyrimethanil (531120), (7.8) 3-(5-fluoro-3,3,4,4-tetramethyl-3,4-dihydroisoquinolin
yl)quinoline (8616477), (7.9) oxytetracycline (792) and (7.10) streptomycin (571), and salts
thereof.
Particular preference is given to combinations comprising an inhibitor of the amino acid and/or protein bio-
synthesis selected from the group consisting of cyprodinyl (1215522) and pyrimethanil (531120),
and salts thereof.
More particular preference is given to combinations comprising an inhibitor of the amino acid and/or pro-
tein biosynthesis selected from the group consisting of pyrimethanil (531120) and salts thereof..
Preference is further given to combinations comprising an inhibitor of the ATP production selected from the
group consisting of [Group (8)]:
(8.1) fentin acetate (9008), (8.2) fentin chloride (6397), (8.3) fentin hydroxide (769) and (8.4)
silthiofam (1752176), and salts thereof.
Preference is further given to combinations comprising an inhibitor of the cell wall synthesis or glucan syn-
thesis selected from the group consisting of [Group (9)]:(9.1) benthiavalicarb (1774067), (9.2) dime-
thomorph (1104885), (9.3) flumorph (2118679), (9.4) iprovalicarb (1409237), (9.5) mandipro-
pamid (3747262), (9.6) polyoxins (111137), (9.7) polyoxorim (229769), (9.8) validamycin A
(372488), (9.9) valifenalate (2831594; 2831590) and (9.10) polyoxin B (193966), and salts
thereof.
Particular preference is given to combinations comprising an inhibitor of the cell wall synthesis or glucan syn-
thesis selected from the group consisting of benthiavalicarb (1774067), dimethomorph (1104885),
iprovalicarb (1409237) and mandipropamid (3747262), and salts thereof.
More particular preference is given to combinations comprising an inhibitor of the cell wall synthesis or glucan
synthesis selected from the group consisting of iprovalicarb (1409237) and salts thereof.
Preference is further given to combinations comprising an inhibitor of the lipid and membrane synthesis se-
lected from the group consisting of [Group (10)]:
(10.1) biphenyl (924), (10.2) chloroneb (26756), (10.3) dicloran (999), (10.4) edifenphos
(171098), (10.5) etridiazole (25939), (10.6) iodocarb (554066), (10.7) iprobenfos (260878),
(10.8) isoprothiolane (505121), (10.9) propamocarb (256061), (10.10) propamocarb hydrochloride
(256061), (10.11) prothiocarb (196223), (10.12) pyrazophos (134576), (10.13) quintozene (82-
68-8), (10.14) tecnazene (1170) and (10.15) tolclofos-methyl (570189), and salts thereof.
Particular preference is given to combinations comprising an inhibitor of the lipid and membrane synthesis
selected from the group consisting of propamocarb (256061) and propamocarb-hydrochloride (25606-
41-1), and salts thereof.
More particular preference is given to combinations comprising an inhibitor of the lipid and membrane syn-
thesis selected from the group consisting of propamocarb (256061) and salts thereof.
Preference is further given to combinations comprising an inhibitor of the melanine biosynthesis selected
from the group consisting of [Group (11)]:
(11.1) carpropamid (1040308), (11.2) diclocymet (1399204), (11.3) fenoxanil (1158527), (11.4)
phthalide (273552), (11.5) pyroquilon (573691), (11.6) tricyclazole (418142) and (11.7) 2,2,2-
trifluoroethyl {3-methyl[(4-methylbenzoyl)amino]butanyl}carbamate (8515246, and salts thereof.
Particular preference is given to combinations comprising an inhibitor of the melanine biosynthesis selected
from the group consisting of tricyclazole (418142), and salts thereof.
Preference is further given to combinations comprising an inhibitor of the nucleic acid synthesis selected
from the group consisting of [Group (12)]:
(12.1) benalaxyl (716264), (12.2) benalaxyl-M (kiralaxyl) (982435), (12.3) bupirimate (41483
6), (12.4) clozylacon (679328), (12.5) dimethirimol (52214), (12.6) ethirimol (239476), (12.7)
furalaxyl (576467), (12.8) hymexazol (100041), (12.9) metalaxyl (578371), (12.10) metalaxyl-
M (mefenoxam) (706300), (12.11) ofurace (588103), (12.12) oxadixyl (777323) and (12.13)
oxolinic acid (146984), and salts thereof.
Particular preference is given to combinations comprising an inhibitor of the nucleic acid synthesis selected
from the group consisting of benalaxyl (716264), benalaxyl-M (kiralaxyl) (982435), metalaxyl
(578371) and metalaxyl-M (mefenoxam) (706300), and salts thereof.
More particular preference is given to combinations comprising an inhibitor of the nucleic acid synthesis se-
lected from the group consisting of metalaxyl (578371) and metalaxyl-M (mefenoxam) (706300),
and salts thereof.
Preference is further given to combinations comprising an inhibitor of the signal transduction selected from
the group consisting of [Group (13)]:
(13.1) chlozolinate (843325), (13.2) fenpiclonil (747383), (13.3) fludioxonil (1313411), (13.4)
iprodione (367347), (13.5) procymidone (328098), (13.6) quinoxyfen (1244957) and (13.7)
vinclozolin (504718), and salts thereof.
Particular preference is given to combinations comprising an inhibitor of the signal transduction selected
from the group consisting of fludioxonil (1313411), iprodione (367347) and vinclozolin (50471
8), and salts thereof.
More particular preference is given to combinations comprising an inhibitor of the signal transduction se-
lected from the group consisting of fludioxonil (1313411), and salts thereof.
Preference is further given to combinations comprising a compound capable of acting as uncoupler selected
from the group consisting of [Group (14)]:
(14.1) binapacryl (4854), (14.2) dinocap (1316), (14.3) ferimzone (892697), (14.4) fluazinam
(796226) and (14.5) meptyldinocap (1316), and salts thereof.
Particular preference is given to combinations comprising a compound capable of acting as uncoupler se-
lected from the group consisting fluazinam (796226) and meptyldinocap (1316), and salts thereof.
Preference is further given to combinations comprising a fungicide selected from the group consisting of
[Group (15)]:
(15.1) benthiazole (215640), (15.2) bethoxazin (1632695), (15.3) capsimycin (706945), (15.4)
carvone (990), (15.5) chinomethionat (24392), (15.6) pyriofenone (chlazafenone) (6880469),
(15.7) cufraneb (110967), (15.8) cyflufenamid (1804093), (15.9) cymoxanil (579667), (15.10)
cyprosulfamide (2216678), (15.11) dazomet (5334), (15.12) debacarb (627326), (15.13) dichlo-
rophen (974), (15.14) diclomezine (628655), (15.15) difenzoquat (498667), (15.16) difenzoquat
methylsulfate (432226), (15.17) diphenylamine (1224), (15.18) ecomate, (15.19) fenpyrazamine
(4737983), (15.20) flumetover (1540254), (15.21) fluoroimide (412054), (15.22) flusulfamide
(1069176), (15.23) flutianil (3049002), (15.24) fosetyl-aluminium (391488), (15.25) fosetyl-
calcium, (15.26) fosetyl-sodium (391488), (15.27) hexachlorobenzene (1181), (15.28) irumamycin
(816041), (15.29) methasulfocarb (669526), (15.30) methyl isothiocyanate (5566), (15.31) me-
trafenone (2208996), (15.32) mildiomycin (675273), (15.33) natamycin (76818), (15.34) nickel
dimethyldithiocarbamate (155210), (15.35) nitrothal-isopropyl (105526), (15.36) octhilinone
(265301), (15.37) oxamocarb (9172427), (15.38) oxyfenthiin (344079), (15.39) pentachloro-
phenol and salts (875), (15.40) phenothrin, (15.41) phosphorous acid and its salts (135982), (15.42)
propamocarb-fosetylate, (15.43) propanosine-sodium (884986), (15.44) proquinazid (1892784),
(15.45) pyrimorph (8683903), (15.45e) (2E)(4-tert-butylphenyl)(2-chloropyridinyl)
(morpholinyl)propenone (12317765), (15.45z) (2Z)(4-tert-butylphenyl)(2-chloropyridin-
4-yl)(morpholinyl)propenone (12317766), (15.46) pyrrolnitrine (10189), (15.47) tebuf-
loquin (3766452), (15.48) tecloftalam (762806), (15.49) tolnifanide (3049116), (15.50) triazox-
ide (724596), (15.51) trichlamide (701934), (15.52) zarilamid (845275), (15.53) (3S,6S,7R,8R)-
8-benzyl[({3-[(isobutyryloxy)methoxy]methoxypyridinyl}carbonyl)amino]methyl-4,9-dioxo-1,5-
dioxonanyl 2-methylpropanoate (5178752), (15.54) 1-(4-{4-[(5R)(2,6-difluorophenyl)-4,5-
dihydro-1,2-oxazolyl]-1,3-thiazolyl}piperidinyl)[5-methyl(trifluoromethyl)-1H-pyrazol
yl]ethanone (10033196), (15.55) 1-(4-{4-[(5S)(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazolyl]-1,3-
thiazolyl}piperidinyl)[5-methyl(trifluoromethyl)-1H-pyrazolyl]ethanone (10033199),
(15.56) 1-(4-{4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazolyl]-1,3-thiazolyl}piperidinyl)[5-
methyl(trifluoromethyl)-1H-pyrazolyl]ethanone (10033189), (15.57) 1-(4-methoxyphenoxy)-3,3-
dimethylbutanyl 1H-imidazolecarboxylate (1112279), (15.58) 2,3,5,6-tetrachloro
(methylsulfonyl)pyridine (131086), (15.59) 2,3-dibutylchlorothieno[2,3-d]pyrimidin-4(3H)-one
(2214517), (15.60) 2,6-dimethyl-1H,5H-[1,4]dithiino[2,3-c:5,6-c']dipyrrole-1,3,5,7(2H,6H)-tetrone,
(15.61) 2-[5-methyl(trifluoromethyl)-1H-pyrazolyl](4-{4-[(5R)phenyl-4,5-dihydro-1,2-oxazol
yl]-1,3-thiazolyl}piperidinyl)ethanone (10033167), (15.62) 2-[5-methyl(trifluoromethyl)-1H-
pyrazolyl](4-{4-[(5S)phenyl-4,5-dihydro-1,2-oxazolyl]-1,3-thiazolyl}piperidinyl)ethanone
(10033168), (15.63) 2-[5-methyl(trifluoromethyl)-1H-pyrazolyl]{4-[4-(5-phenyl-4,5-dihydro-
1,2-oxazolyl)-1,3-thiazolyl]piperidinyl}ethanone (10033165), (15.64) 2-butoxyiodo
propyl-4H-chromenone, (15.65) 2-chloro[2-chloro(2,6-difluoromethoxyphenyl)methyl-1H-
imidazolyl]pyridine, (15.66) 2-phenylphenol and salts (907), (15.67) 3-(4,4,5-trifluoro-3,3-dimethyl-
3,4-dihydroisoquinolinyl)quinoline (8616470), (15.68) 3,4,5-trichloropyridine-2,6-dicarbonitrile
(178240), (15.69) 3-[5-(4-chlorophenyl)-2,3-dimethyl-1,2-oxazolidinyl]pyridine, (15.70) 3-chloro
(4-chlorophenyl)(2,6-difluorophenyl)methylpyridazine, (15.71) 4-(4-chlorophenyl)(2,6-
difluorophenyl)-3,6-dimethylpyridazine, (15.72) 5-amino-1,3,4-thiadiazolethiol, (15.73) 5-chloro-N'-
phenyl-N'-(propynyl)thiophenesulfonohydrazide (1346), (15.74) 5-fluoro[(4-
fluorobenzyl)oxy]pyrimidinamine (11743764), (15.75) 5-fluoro[(4-methylbenzyl)oxy]pyrimidin-
4-amine (11743760), (15.76) 5-methyloctyl[1,2,4]triazolo[1,5-a]pyrimidinamine, (15.77) ethyl
(2Z)aminocyanophenylpropenoate, (15.78) N'-(4-{[3-(4-chlorobenzyl)-1,2,4-thiadiazol
yl]oxy}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide, (15.79) N-(4-chlorobenzyl)[3-methoxy-
4-(propynyloxy)phenyl]propanamide, (15.80) N-[(4-chlorophenyl)(cyano)methyl][3-methoxy
(propynyloxy)phenyl]propanamide, (15.81) N-[(5-bromochloropyridinyl)methyl]-2,4-
dichloropyridinecarboxamide, (15.82) N-[1-(5-bromochloropyridinyl)ethyl]-2,4-dichloropyridine
carboxamide, (15.83) N-[1-(5-bromochloropyridinyl)ethyl]fluoroiodopyridinecarboxamide,
(15.84) N-{(E)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-difluorophenyl]methyl}
phenylacetamide (2212019), (15.85) N-{(Z)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-
difluorophenyl]methyl}phenylacetamide (2212019), (15.86) N'-{4-[(3-tert-butylcyano-1,2-thiazol-
-yl)oxy]chloromethylphenyl}-N-ethyl-N-methylimidoformamide, (15.87) N-methyl(1-{[5-methyl-
3-(trifluoromethyl)-1H-pyrazolyl]acetyl}piperidinyl)-N-(1,2,3,4-tetrahydronaphthalenyl)-1,3-
thiazolecarboxamide (9225146), (15.88) N-methyl(1-{[5-methyl(trifluoromethyl)-1H-pyrazol-
1-yl]acetyl}piperidinyl)-N-[(1R)-1,2,3,4-tetrahydronaphthalenyl]-1,3-thiazolecarboxamide
(9225146), (15.89) N-methyl(1-{[5-methyl(trifluoromethyl)-1H-pyrazolyl]acetyl}piperidin
yl)-N-[(1S)-1,2,3,4-tetrahydronaphthalenyl]-1,3-thiazolecarboxamide (9225145), (15.90) pentyl
{6-[({[(1-methyl-1H-tetrazolyl)(phenyl)methylidene]amino}oxy)methyl]pyridinyl}carbamate, (15.91)
phenazinecarboxylic acid, (15.92) quinolinol (1346), (15.93) quinolinol sulfate (2:1) (1346)
and (15.94) tert-butyl {6-[({[(1-methyl-1H-tetrazolyl)(phenyl)methylene]amino}oxy)methyl]pyridin
yl}carbamate, and salts thereof.
Particular preference is given to combinations comprising a fungicide selected from the group consisting of
fosetyl-Al (391488), metrafenone (2208996), propamocarb-fosetylate, proquinazid (1892784), N-
methyl(1-{[5-methyl(trifluoromethyl)-1H-pyrazolyl]acetyl}piperidinyl)-N-[(1R)-1,2,3,4-
tetrahydronaphthalenyl]-1,3-thiazolecarboxamide (9225146), N-methyl(1-{[5-methyl
(trifluoromethyl)-1H-pyrazolyl]acetyl}piperidinyl)-N-(1,2,3,4-tetrahydronaphthalenyl)-1,3-thiazole
carboxamide (9225146), 1-(4-{4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazolyl]-1,3-thiazol
yl}piperidinyl)[5-methyl(trifluoromethyl)-1H-pyrazolyl]ethanone (10033189) and 2-butoxy
iodopropyl-4H-chromenone, and salts thereof..
More particular preference is given to combinations comprising a fungicide selected from the group consist-
ing of fosetyl-Al (391488), and salts thereof.
Preference is further given to combinations comprising a fungicide selected from the group consisting of
[Group (16)]:
(16.1) 1-methyl(trifluoromethyl)-N-[2'-(trifluoromethyl)biphenylyl]-1H-pyrazolecarboxamide,
(16.2) N-(4'-chlorobiphenylyl)(difluoromethyl)methyl-1H-pyrazolecarboxamide, (16.3) N-(2',4'-
dichlorobiphenylyl)(difluoromethyl)methyl-1H-pyrazolecarboxamide, (16.4) 3-(difluoromethyl)-
1-methyl-N-[4'-(trifluoromethyl)biphenylyl]-1H-pyrazolecarboxamide, (16.5) N-(2',5'-
difluorobiphenylyl)methyl(trifluoromethyl)-1H-pyrazolecarboxamide, (16.6) 3-(difluoromethyl)-
1-methyl-N-[4'-(propynyl)biphenylyl]-1H-pyrazolecarboxamide, (16.7) 5-fluoro-1,3-dimethyl-N-
[4'-(propynyl)biphenylyl]-1H-pyrazolecarboxamide, (16.8) 2-chloro-N-[4'-(propyn
yl)biphenylyl]pyridinecarboxamide, (16.9) 3-(difluoromethyl)-N-[4'-(3,3-dimethylbutyn
yl)biphenylyl]methyl-1H-pyrazolecarboxamide, (16.10) N-[4'-(3,3-dimethylbutynyl)biphenyl-
2-yl]fluoro-1,3-dimethyl-1H-pyrazolecarboxamide, (16.11) 3-(difluoromethyl)-N-(4'-ethynylbiphenyl-
2-yl)methyl-1H-pyrazolecarboxamide, (16.12) N-(4'-ethynylbiphenylyl)fluoro-1,3-dimethyl-1H-
pyrazolecarboxamide, (16.13) 2-chloro-N-(4'-ethynylbiphenylyl)pyridinecarboxamide, (16.14) 2-
chloro-N-[4'-(3,3-dimethylbutynyl)biphenylyl]pyridinecarboxamide, (16.15) 4-(difluoromethyl)-
2-methyl-N-[4'-(trifluoromethyl)biphenylyl]-1,3-thiazolecarboxamide, (16.16) 5-fluoro-N-[4'-(3-
hydroxymethylbutynyl)biphenylyl]-1,3-dimethyl-1H-pyrazolecarboxamide, (16.17) 2-chloro-
N-[4'-(3-hydroxymethylbutynyl)biphenylyl]pyridinecarboxamide, (16.18) 3-(difluoromethyl)-
N-[4'-(3-methoxymethylbutynyl)biphenylyl]methyl-1H-pyrazolecarboxamide, (16.19) 5-
fluoro-N-[4'-(3-methoxymethylbutynyl)biphenylyl]-1,3-dimethyl-1H-pyrazolecarboxamide,
(16.20) 2-chloro-N-[4'-(3-methoxymethylbutynyl)biphenylyl]pyridinecarboxamide, (16.21)
(5-bromomethoxymethylpyridinyl)(2,3,4-trimethoxymethylphenyl)methanone, (16.22) N-[2-(4-
{[3-(4-chlorophenyl)propynyl]oxy}methoxyphenyl)ethyl]-N2-(methylsulfonyl)valinamide (220706-
93-4), (16.23) 4-oxo[(2-phenylethyl)amino]butanoic acid, (16.24) butynyl {6-[({[(Z)-(1-methyl-1H-
tetrazolyl)(phenyl)methylene]amino}oxy)methyl]pyridinyl}carbamate, (16.25) 4-Amino
fluorpyrimidinol (mesomere form: 6-Aminofluorpyrimidin-2(1H)-on), (16.26) propyl 3,4,5-
trihydroxybenzoate, (16.27) 1,3-dimethyl-N-(1,1,3-trimethyl-2,3-dihydro-1H-indenyl)-1H-pyrazole
carboxamide (1051132), (16.28) 1,3-dimethyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H-indenyl]-1H-
pyrazolecarboxamide, (16.29) 1,3-dimethyl-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-1H-indenyl]-1H-
pyrazolecarboxamide, (16.30) [3-(4-chlorofluorophenyl)(2,4-difluorophenyl)-1,2-oxazolyl](pyridin-
3-yl)methanol (12296052), (16.31) (S)-[3-(4-chlorofluorophenyl)(2,4-difluorophenyl)-1,2-oxazol
yl](pyridinyl)methanol (12296065), (16.32) (R)-[3-(4-chlorofluorophenyl)(2,4-difluorophenyl)-
1,2-oxazolyl](pyridinyl)methanol (12296063), (16.33) 2-{[3-(2-chlorophenyl)(2,4-difluorophenyl)-
oxiranyl]methyl}-2,4-dihydro-3H-1,2,4-triazolethione (13422608), (16.34) 1-{[3-(2-chlorophenyl)
(2,4-difluorophenyl)oxiranyl]methyl}-1H-1,2,4-triazolyl thiocyanate (13422607), (16.35) 5-
(allylsulfanyl){[3-(2-chlorophenyl)(2,4-difluorophenyl)oxiranyl]methyl}-1H-1,2,4-triazole (1342260-
41-6), (16.36) 2-fluoro(trifluoromethyl)-N-(1,1,3-trimethyl-2,3-dihydro-1H-indenyl)benzamide, (16.37)
2-fluoro(trifluoromethyl)-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H-indenyl]benzamide and (16.38) 2-
fluoro(trifluoromethyl)-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-1H-indenyl]benzamide, and salts thereof.
All named mixing partners of the classes (1) to (16) can, if their functional groups enable this, optionally
form salts with suitable bases or acids.
In general component (B) is selected from the compounds mentioned in List L1:
(1.1) aldimorph (17045), (1.2) azaconazole (602070), (1.3) bitertanol (551792), (1.4) bromuco-
nazole (1162552), (1.5) cyproconazole (1130964), (1.6) diclobutrazole (757363), (1.7) difeno-
conazole (1194463), (1.8) diniconazole (836573), (1.9) diniconazole-M (836575), (1.10) dode-
morph (15937), (1.11) dodemorph acetate (317170), (1.12) epoxiconazole (1063250), (1.13)
etaconazole (602074), (1.14) fenarimol (601689), (1.15) fenbuconazole (1143696), (1.16) fen-
hexamid (1268338), (1.17) fenpropidin (673067), (1.18) fenpropimorph (673060), (1.19) flu-
quinconazole (1364265), (1.20) flurprimidol (564253), (1.21) flusilazole (855099), (1.22) flu-
triafol (766740), (1.23) furconazole (1128395), (1.24) furconazole-cis (1128394), (1.25) hex-
aconazole (799834), (1.26) imazalil (605347), (1.27) imazalil sulfate (585942), (1.28) imiben-
conazole (865987), (1.29) ipconazole (1252257), (1.30) metconazole (1251166), (1.31) myclo-
butanil (886710), (1.32) naftifine (654720), (1.33) nuarimol (632849), (1.34) oxpoconazole
(1742125), (1.35) paclobutrazol (767380), (1.36) pefurazoate (1019034), (1.37) penconazole
(662466), (1.38) piperalin (34782), (1.39) prochloraz (677475), (1.40) propiconazole (60207-
90-1), (1.41) prothioconazole (1789286), (1.42) pyributicarb (886785), (1.43) pyrifenox (88283
4), (1.44) quinconazole (1039708), (1.45) simeconazole (1495087), (1.46) spiroxamine (118134
8), (1.47) tebuconazole (1075343), (1.48) terbinafine (911616), (1.49) tetraconazole (1122813),
(1.50) triadimefon (431213), (1.51) triadimenol (894827), (1.52) tridemorph (814123), (1.53)
triflumizole (686941), (1.54) triforine (266442), (1.55) triticonazole (1319837), (1.56) unicona-
zole (836571), (1.57) uniconazole-p (836574), (1.58) viniconazole (771744), (1.59) voricona-
zole (1372349), (1.60) 1-(4-chlorophenyl)(1H-1,2,4-triazolyl)cycloheptanol (1295869), (1.61)
methyl 1-(2,2-dimethyl-2,3-dihydro-1H-indenyl)-1H-imidazolecarboxylate (1103230), (1.62) N'-
{5-(difluoromethyl)methyl[3-(trimethylsilyl)propoxy]phenyl}-N-ethyl-N-methylimidoformamide,
(1.63) N-ethyl-N-methyl-N'-{2-methyl(trifluoromethyl)[3-(trimethylsilyl)-
propoxy]phenyl}imidoformamide (1.64) O-[1-(4-methoxyphenoxy)-3,3-dimethylbutanyl] 1H-imidazole-
1-carbothioate (1112262), (2.1) bixafen (5818093), (2.2) boscalid (1884256), (2.3) carboxin
(52344), (2.4) diflumetorim (1303390), (2.5) fenfuram (246913), (2.6) fluopyram (658066
4), (2.7) flutolanil (663325), (2.8) fluxapyroxad (9072043), (2.9) furametpyr (1235723), (2.10)
furmecyclox (605680), (2.11) isopyrazam (mixture of syn-epimeric racemate 1RS,4SR,9RS and anti-
epimeric racemate 1RS,4SR,9SR) (8816851), (2.12) isopyrazam (anti-epimeric racemate
1RS,4SR,9SR), (2.13) isopyrazam (anti-epimeric enantiomer 1R,4S,9S), (2.14) isopyrazam (anti-epimeric
enantiomer 1S,4R,9R), (2.15) isopyrazam (syn epimeric racemate 1RS,4SR,9RS), (2.16) isopyrazam (syn-
epimeric enantiomer 1R,4S,9R), (2.17) isopyrazam (syn-epimeric enantiomer 1S,4R,9S), (2.18) mepronil
(558140), (2.19) oxycarboxin (52591), (2.20) penflufen (4947938), (2.21) penthiopyrad
(1836753), (2.22) sedaxane (8749676), (2.23) thifluzamide (1300007), (2.24) 1-methyl-N-[2-
(1,1,2,2-tetrafluoroethoxy)phenyl](trifluoromethyl)-1H-pyrazolecarboxamide, (2.25) 3-
(difluoromethyl)methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-1H-pyrazolecarboxamide, (2.26) 3-
(difluoromethyl)-N-[4-fluoro(1,1,2,3,3,3-hexafluoropropoxy)phenyl]methyl-1H-pyrazole
carboxamide, (2.27) N-[1-(2,4-dichlorophenyl)methoxypropanyl](difluoromethyl)methyl-1H-
pyrazolecarboxamide (10924007), (2.28) 5,8-difluoro-N-[2-(2-fluoro{[4-(trifluoromethyl)pyridin-
2-yl]oxy}phenyl)ethyl]quinazolinamine (12100700), (2.29) benzovindiflupyr, (2.30) N-[(1S,4R)
(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalenyl](difluoromethyl)methyl-1H-
pyrazolecarboxamide, (2.31) N-[(1R,4S)(dichloromethylene)-1,2,3,4-tetrahydro-1,4-
methanonaphthalenyl](difluoromethyl)methyl-1H-pyrazolecarboxamide, (2.32) 3-
(Difluormethyl)methyl-N-(1,1,3-trimethyl-2,3-dihydro-1H-indenyl)-1H-pyrazolcarboxamide, (2.33)
1,3,5-Trimethyl-N-(1,1,3-trimethyl-2,3-dihydro-1H-indenyl)-1H-pyrazolcarboxamide, (2.34) 1-
Methyl(trifluormethyl)-N-(1,3,3-trimethyl-2,3-dihydro-1H-indenyl)-1H-pyrazolcarboxamide, (2.35)
1-Methyl(trifluormethyl)-N-[(1S)-1,3,3-trimethyl-2,3-dihydro-1H-indenyl]-1H-pyrazol
carboxamide, (2.36) 1-Methyl(trifluormethyl)-N-[(1R)-1,3,3-trimethyl-2,3-dihydro-1H-indenyl]-1H-
pyrazolcarboxamide, (2.37) 3-(Difluormethyl)methyl-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-1H-inden
yl]-1H-pyrazolcarboxamide, (2.38) 3-(Difluormethyl)methyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H-
indenyl]-1H-pyrazolcarboxamide, (2.39) 1,3,5-Trimethyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H-
indenyl]-1H-pyrazolcarboxamide, (2.40) 1,3,5-Trimethyl-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-1H-
indenyl]-1H-pyrazolcarboxamide, (2.41) benodanil (153107), (3.1) ametoctradin (8653184),
(3.2) amisulbrom (3486350), (3.3) azoxystrobin (1318608), (3.4) cyazofamid (1201163), (3.5)
coumethoxystrobin (8508810), (3.6) coumoxystrobin (8508818), (3.7) dimoxystrobin (141600
4), (3.8) enestroburin (2384102), (3.9) famoxadone (1318073), (3.10) fenamidone (1613267),
(3.11) fenoxystrobin (9181624), (3.12) fluoxastrobin (3613779), (3.13) kresoxim-methyl (143390-
89-0), (3.14) metominostrobin (1334081), (3.15) orysastrobin (1898921), (3.16) picoxystrobin
(1174285), (3.17) pyraclostrobin (1750130), (3.18) pyrametostrobin (9154107), (3.19) pyraox-
ystrobin (8625882), (3.20) pyribencarb (7992472), (3.21) triclopyricarb (9027601), (3.22) trif-
loxystrobin (1415177), (3.23) (2E)(2-{[6-(3-chloromethylphenoxy)fluoropyrimidin
yl]oxy}phenyl)(methoxyimino)-N-methylethanamide, (3.24) (2E)(methoxyimino)-N-methyl(2-
{[({(1E)[3-(trifluoromethyl)phenyl]-ethylidene}amino)oxy]methyl}-phenyl)ethanamide, (3.25) (2E)
(methoxyimino)-N-methyl{2-[(E)-({1-[3-(trifluoromethyl)phenyl]-
ethoxy}imino)methyl]phenyl}ethanamide (1581694), (3.26) (2E){2-[({[(1E)(3-{[(E)fluoro
phenylethenyl]oxy}phenyl)ethylidene]amino}oxy)methyl]phenyl}(methoxyimino)-N-methylethanamide
(3268960), (3.27) (2E){2-[({[(2E,3E)(2,6-dichlorophenyl)butenylidene]amino}oxy)methyl]-
phenyl}(methoxyimino)-N-methylethanamide, (3.28) 2-chloro-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-
4-yl)pyridinecarboxamide (1198998), (3.29) 5-methoxymethyl(2-{[({(1E)[3-
(trifluoromethyl)phenyl]ethylidene}amino)oxy]methyl}-phenyl)-2,4-dihydro-3H-1,2,4-triazolone, (3.30)
methyl (2E){2-[({cyclopropyl[(4-methoxyphenyl)imino]methyl}sulfanyl)methyl]phenyl}
methoxypropenoate (1496016), (3.31) N-(3-ethyl-3,5,5-trimethylcyclohexyl)(formylamino)
hydroxybenzamide (2265519), (3.32) 2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}methoxy-N-
methylacetamide (1736620), (3.33) (2R){2-[(2,5-dimethylphenoxy)methyl]phenyl}methoxy-N-
methylacetamide (3946570), (4.1) benomyl (178042), (4.2) carbendazim (106057), (4.3) chlor-
fenazole (35747), (4.4) diethofencarb (871309), (4.5) ethaboxam (1626503), (4.6) fluopicolide
(2391107), (4.7) fuberidazole (38781), (4.8) pencycuron (660636), (4.9) thiabendazole (148
8), (4.10) thiophanate-methyl (235648), (4.11) thiophanate (235649), (4.12) zoxamide (156052
), (4.13) 5-chloro(4-methylpiperidinyl)(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine
(2147063), (4.14) 3-chloro(6-chloropyridinyl)methyl(2,4,6-trifluorophenyl)pyridazine
(10027567), (5.1) bordeaux mixture (80110), (5.2) captafol (24251), (5.3) captan (1332),
(5.4) chlorothalonil (18976), (5.5) copper hydroxide (204272), (5.6) copper naphthenate (1338
9), (5.7) copper oxide (13171), (5.8) copper oxychloride (13327), (5.9) copper(2+) sulfate (7758-
98-7), (5.10) dichlofluanid (10859), (5.11) dithianon (33476), (5.12) dodine (24393), (5.13) do-
dine free base, (5.14) ferbam (144841), (5.15) fluorofolpet (7190), (5.16) folpet (1333), (5.17)
guazatine (1081736), (5.18) guazatine acetate, (5.19) iminoctadine (135163), (5.20) iminoctadine
albesilate (1692026), (5.21) iminoctadine triacetate (575209), (5.22) mancopper (539885),
(5.23) mancozeb (80187), (5.24) maneb (124272), (5.25) metiram (90062), (5.26) metiram zinc
(90062), (5.27) oxine-copper (103806), (5.28) propamidine (1045), (5.29) propineb (12071
9), (5.30) sulfur and sulfur preparations including calcium polysulfide (77049), (5.31) thiram (137
8), (5.32) tolylfluanid (7311), (5.33) zineb (121227), (5.34) ziram (1374), (5.35) anilazine (101-
05-3), (6.1) acibenzolar-S-methyl (1351582), (6.2) isotianil (2240491), (6.3) probenazole (27605-
76-1), (6.4) tiadinil (2235806), (6.5) laminarin (90084), (7.1) andoprim (239511), (7.2) blasti-
cidin-S (20797), (7.3) cyprodinil (1215522), (7.4) kasugamycin (69803), (7.5) kasugamycin hy-
drochloride hydrate (194089), (7.6) mepanipyrim (1102357), (7.7) pyrimethanil (531120), (7.8)
3-(5-fluoro-3,3,4,4-tetramethyl-3,4-dihydroisoquinolinyl)quinoline (8616477), (7.9) oxytetracycline
(792), (7.10) streptomycin (571), (8.1) fentin acetate (9008), (8.2) fentin chloride (6397),
(8.3) fentin hydroxide (769), (8.4) silthiofam (1752176), (9.1) benthiavalicarb (1774067), (9.2)
dimethomorph (1104885), (9.3) flumorph (2118679), (9.4) iprovalicarb (1409237), (9.5)
mandipropamid (3747262), (9.6) polyoxins (111137), (9.7) polyoxorim (229769), (9.8) valida-
mycin A (372488), (9.9) valifenalate (2831594; 2831590), (9.10) polyoxin B (193966),
(10.1) biphenyl (924), (10.2) chloroneb (26756), (10.3) dicloran (999), (10.4) edifenphos
(171098), (10.5) etridiazole (25939), (10.6) iodocarb (554066), (10.7) iprobenfos (260878),
(10.8) isoprothiolane (505121), (10.9) propamocarb (256061), (10.10) propamocarb hydrochloride
(256061), (10.11) prothiocarb (196223), (10.12) pyrazophos (134576), (10.13) quintozene (82-
68-8), (10.14) tecnazene (1170), (10.15) tolclofos-methyl (570189), (11.1) carpropamid (104030-
54-8), (11.2) diclocymet (1399204), (11.3) fenoxanil (1158527), (11.4) phthalide (273552),
(11.5) pyroquilon (573691), (11.6) tricyclazole (418142), (11.7) 2,2,2-trifluoroethyl {3-methyl
[(4-methylbenzoyl)amino]butanyl}carbamate (8515246), (12.1) benalaxyl (716264), (12.2)
benalaxyl-M (kiralaxyl) (982435), (12.3) bupirimate (414836), (12.4) clozylacon (679328),
(12.5) dimethirimol (52214), (12.6) ethirimol (239476), (12.7) furalaxyl (576467), (12.8) hy-
mexazol (100041), (12.9) metalaxyl (578371), (12.10) metalaxyl-M (mefenoxam) (706300),
(12.11) ofurace (588103), (12.12) oxadixyl (777323), (12.13) oxolinic acid (146984), (13.1)
chlozolinate (843325), (13.2) fenpiclonil (747383), (13.3) fludioxonil (1313411), (13.4)
iprodione (367347), (13.5) procymidone (328098), (13.6) quinoxyfen (1244957), (13.7) vinclo-
zolin (504718), (14.1) binapacryl (4854), (14.2) dinocap (1316), (14.3) ferimzone (892697),
(14.4) fluazinam (796226), (14.5) meptyldinocap (1316), (15.1) benthiazole (215640), (15.2)
bethoxazin (1632695), (15.3) capsimycin (706945), (15.4) carvone (990), (15.5) chinomethionat
(24392), (15.6) pyriofenone (chlazafenone) (6880469), (15.7) cufraneb (110967), (15.8) cyflu-
fenamid (1804093), (15.9) cymoxanil (579667), (15.10) cyprosulfamide (2216678), (15.11) da-
zomet (5334), (15.12) debacarb (627326), (15.13) dichlorophen (974), (15.14) diclomezine
(628655), (15.15) difenzoquat (498667), (15.16) difenzoquat methylsulfate (432226), (15.17)
diphenylamine (1224), (15.18) ecomate, (15.19) fenpyrazamine (4737983), (15.20) flumetover
(1540254), (15.21) fluoroimide (412054), (15.22) flusulfamide (1069176), (15.23) flutianil
(3049002), (15.24) fosetyl-aluminium (391488), (15.25) fosetyl-calcium, (15.26) fosetyl-sodium
(391488), (15.27) hexachlorobenzene (1181), (15.28) irumamycin (816041), (15.29) methasul-
focarb (669526), (15.30) methyl isothiocyanate (5566), (15.31) metrafenone (2208996), (15.32)
mildiomycin (675273), (15.33) natamycin (76818), (15.34) nickel dimethyldithiocarbamate (15521-
65-0), (15.35) nitrothal-isopropyl (105526), (15.36) octhilinone (265301), (15.37) oxamocarb
(9172427), (15.38) oxyfenthiin (344079), (15.39) pentachlorophenol and salts (875), (15.40)
phenothrin, (15.41) phosphorous acid and its salts (135982), (15.42) propamocarb-fosetylate, (15.43)
propanosine-sodium (884986), (15.44) proquinazid (1892784), (15.45) pyrimorph (8683903),
(15.45e) (2E)(4-tert-butylphenyl)(2-chloropyridinyl)(morpholinyl)propenone (1231776-
28-5), (15.45z) (2Z)(4-tert-butylphenyl)(2-chloropyridinyl)(morpholinyl)propenone
(12317766), (15.46) pyrrolnitrine (10189), (15.47) tebufloquin (3766452), (15.48) tecloftalam
(762806), (15.49) tolnifanide (3049116), (15.50) triazoxide (724596), (15.51) trichlamide
(701934), (15.52) zarilamid (845275), (15.53) (3S,6S,7R,8R)benzyl[({3-
[(isobutyryloxy)methoxy]methoxypyridinyl}carbonyl)amino]methyl-4,9-dioxo-1,5-dioxonanyl
2-methylpropanoate (5178752), (15.54) 1-(4-{4-[(5R)(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol
yl]-1,3-thiazolyl}piperidinyl)[5-methyl(trifluoromethyl)-1H-pyrazolyl]ethanone (1003319
6), (15.55) 1-(4-{4-[(5S)(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazolyl]-1,3-thiazolyl}piperidin
yl)[5-methyl(trifluoromethyl)-1H-pyrazolyl]ethanone (10033199), (15.56) 1-(4-{4-[5-(2,6-
difluorophenyl)-4,5-dihydro-1,2-oxazolyl]-1,3-thiazolyl}piperidinyl)[5-methyl
(trifluoromethyl)-1H-pyrazolyl]ethanone (10033189), (15.57) 1-(4-methoxyphenoxy)-3,3-
dimethylbutanyl 1H-imidazolecarboxylate (1112279), (15.58) 2,3,5,6-tetrachloro
(methylsulfonyl)pyridine (131086), (15.59) 2,3-dibutylchlorothieno[2,3-d]pyrimidin-4(3H)-one
(2214517), (15.60) 2,6-dimethyl-1H,5H-[1,4]dithiino[2,3-c:5,6-c']dipyrrole-1,3,5,7(2H,6H)-tetrone,
(15.61) 2-[5-methyl(trifluoromethyl)-1H-pyrazolyl](4-{4-[(5R)phenyl-4,5-dihydro-1,2-oxazol
yl]-1,3-thiazolyl}piperidinyl)ethanone (10033167), (15.62) 2-[5-methyl(trifluoromethyl)-1H-
pyrazolyl](4-{4-[(5S)phenyl-4,5-dihydro-1,2-oxazolyl]-1,3-thiazolyl}piperidinyl)ethanone
(10033168), (15.63) 2-[5-methyl(trifluoromethyl)-1H-pyrazolyl]{4-[4-(5-phenyl-4,5-dihydro-
1,2-oxazolyl)-1,3-thiazolyl]piperidinyl}ethanone (10033165), (15.64) 2-butoxyiodo
propyl-4H-chromenone, (15.65) 2-chloro[2-chloro(2,6-difluoromethoxyphenyl)methyl-1H-
imidazolyl]pyridine, (15.66) 2-phenylphenol and salts (907), (15.67) 3-(4,4,5-trifluoro-3,3-dimethyl-
3,4-dihydroisoquinolinyl)quinoline (8616470), (15.68) 3,4,5-trichloropyridine-2,6-dicarbonitrile
(178240), (15.69) 3-[5-(4-chlorophenyl)-2,3-dimethyl-1,2-oxazolidinyl]pyridine, (15.70) 3-chloro
(4-chlorophenyl)(2,6-difluorophenyl)methylpyridazine, (15.71) 4-(4-chlorophenyl)(2,6-
difluorophenyl)-3,6-dimethylpyridazine, (15.72) 5-amino-1,3,4-thiadiazolethiol, (15.73) 5-chloro-N'-
phenyl-N'-(propynyl)thiophenesulfonohydrazide (1346), (15.74) 5-fluoro[(4-
fluorobenzyl)oxy]pyrimidinamine (11743764), (15.75) 5-fluoro[(4-methylbenzyl)oxy]pyrimidin-
4-amine (11743760), (15.76) 5-methyloctyl[1,2,4]triazolo[1,5-a]pyrimidinamine, (15.77) ethyl
(2Z)aminocyanophenylpropenoate, (15.78) N'-(4-{[3-(4-chlorobenzyl)-1,2,4-thiadiazol
yl]oxy}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide, (15.79) N-(4-chlorobenzyl)[3-methoxy-
4-(propynyloxy)phenyl]propanamide, (15.80) N-[(4-chlorophenyl)(cyano)methyl][3-methoxy
(propynyloxy)phenyl]propanamide, (15.81) N-[(5-bromochloropyridinyl)methyl]-2,4-
dichloropyridinecarboxamide, (15.82) N-[1-(5-bromochloropyridinyl)ethyl]-2,4-dichloropyridine
carboxamide, (15.83) N-[1-(5-bromochloropyridinyl)ethyl]fluoroiodopyridinecarboxamide,
(15.84) N-{(E)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-difluorophenyl]methyl}
phenylacetamide (2212019), (15.85) N-{(Z)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-
difluorophenyl]methyl}phenylacetamide (2212019), (15.86) N'-{4-[(3-tert-butylcyano-1,2-thiazol-
-yl)oxy]chloromethylphenyl}-N-ethyl-N-methylimidoformamide, (15.87) N-methyl(1-{[5-methyl-
3-(trifluoromethyl)-1H-pyrazolyl]acetyl}piperidinyl)-N-(1,2,3,4-tetrahydronaphthalenyl)-1,3-
thiazolecarboxamide (9225146), (15.88) N-methyl(1-{[5-methyl(trifluoromethyl)-1H-pyrazol-
1-yl]acetyl}piperidinyl)-N-[(1R)-1,2,3,4-tetrahydronaphthalenyl]-1,3-thiazolecarboxamide
(9225146), (15.89) N-methyl(1-{[5-methyl(trifluoromethyl)-1H-pyrazolyl]acetyl}piperidin
yl)-N-[(1S)-1,2,3,4-tetrahydronaphthalenyl]-1,3-thiazolecarboxamide (9225145), (15.90) pentyl
{6-[({[(1-methyl-1H-tetrazolyl)(phenyl)methylidene]amino}oxy)methyl]pyridinyl}carbamate, (15.91)
phenazinecarboxylic acid, (15.92) quinolinol (1346), (15.93) quinolinol sulfate (2:1) (134
6), (15.94) tert-butyl {6-[({[(1-methyl-1H-tetrazolyl)(phenyl)methylene]amino}oxy)methyl]pyridin
yl}carbamate, (16.1) 1-methyl(trifluoromethyl)-N-[2'-(trifluoromethyl)biphenylyl]-1H-pyrazole
carboxamide, (16.2) N-(4'-chlorobiphenylyl)(difluoromethyl)methyl-1H-pyrazolecarboxamide,
(16.3) N-(2',4'-dichlorobiphenylyl)(difluoromethyl)methyl-1H-pyrazolecarboxamide, (16.4) 3-
(difluoromethyl)methyl-N-[4'-(trifluoromethyl)biphenylyl]-1H-pyrazolecarboxamide, (16.5) N-
(2',5'-difluorobiphenylyl)methyl(trifluoromethyl)-1H-pyrazolecarboxamide, (16.6) 3-
(difluoromethyl)methyl-N-[4'-(propynyl)biphenylyl]-1H-pyrazolecarboxamide, (16.7) 5-
fluoro-1,3-dimethyl-N-[4'-(propynyl)biphenylyl]-1H-pyrazolecarboxamide, (16.8) 2-chloro-N-
[4'-(propynyl)biphenylyl]pyridinecarboxamide, (16.9) 3-(difluoromethyl)-N-[4'-(3,3-
dimethylbutynyl)biphenylyl]methyl-1H-pyrazolecarboxamide, (16.10) N-[4'-(3,3-dimethylbut-
1-ynyl)biphenylyl]fluoro-1,3-dimethyl-1H-pyrazolecarboxamide, (16.11) 3-(difluoromethyl)-N-
(4'-ethynylbiphenylyl)methyl-1H-pyrazolecarboxamide, (16.12) N-(4'-ethynylbiphenylyl)
fluoro-1,3-dimethyl-1H-pyrazolecarboxamide, (16.13) 2-chloro-N-(4'-ethynylbiphenylyl)pyridine
carboxamide, (16.14) 2-chloro-N-[4'-(3,3-dimethylbutynyl)biphenylyl]pyridinecarboxamide,
(16.15) 4-(difluoromethyl)methyl-N-[4'-(trifluoromethyl)biphenylyl]-1,3-thiazolecarboxamide,
(16.16) 5-fluoro-N-[4'-(3-hydroxymethylbutynyl)biphenylyl]-1,3-dimethyl-1H-pyrazole
carboxamide, (16.17) 2-chloro-N-[4'-(3-hydroxymethylbutynyl)biphenylyl]pyridine
carboxamide, (16.18) 3-(difluoromethyl)-N-[4'-(3-methoxymethylbutynyl)biphenylyl]methyl-
1H-pyrazolecarboxamide, (16.19) 5-fluoro-N-[4'-(3-methoxymethylbutynyl)biphenylyl]-1,3-
dimethyl-1H-pyrazolecarboxamide, (16.20) 2-chloro-N-[4'-(3-methoxymethylbutynyl)biphenyl-
2-yl]pyridinecarboxamide, (16.21) (5-bromomethoxymethylpyridinyl)(2,3,4-trimethoxy
methylphenyl)methanone, (16.22) N-[2-(4-{[3-(4-chlorophenyl)propynyl]oxy}
methoxyphenyl)ethyl]-N2-(methylsulfonyl)valinamide (2207064), (16.23) 4-oxo[(2-
phenylethyl)amino]butanoic acid, (16.24) butynyl {6-[({[(Z)-(1-methyl-1H-tetrazol
yl)(phenyl)methylene]amino}oxy)methyl]pyridinyl}carbamate, (16.25) 4-Aminofluorpyrimidinol
(mesomere Form: 6-Aminofluorpyrimidin-2(1H)-on), (16.26) propyl 3,4,5-trihydroxybenzoate, (16.27)
1,3-dimethyl-N-(1,1,3-trimethyl-2,3-dihydro-1H-indenyl)-1H-pyrazolecarboxamide (1051132),
(16.28) 1,3-dimethyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H-indenyl]-1H-pyrazolecarboxamide, (16.29)
1,3-dimethyl-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-1H-indenyl]-1H-pyrazolecarboxamide, (16.30) [3-(4-
chlorofluorophenyl)(2,4-difluorophenyl)-1,2-oxazolyl](pyridinyl)methanol (12296052), (16.31)
(S)-[3-(4-chlorofluorophenyl)(2,4-difluorophenyl)-1,2-oxazolyl](pyridinyl)methanol (1229606
), (16.32) (R)-[3-(4-chlorofluorophenyl)(2,4-difluorophenyl)-1,2-oxazolyl](pyridinyl)methanol
(12296063), (16.33) 2-{[3-(2-chlorophenyl)(2,4-difluorophenyl)oxiranyl]methyl}-2,4-dihydro-3H-
1,2,4-triazolethione (13422608), (16.34) 1-{[3-(2-chlorophenyl)(2,4-difluorophenyl)oxiran
yl]methyl}-1H-1,2,4-triazolyl thiocyanate (13422607), (16.35) 5-(allylsulfanyl){[3-(2-chlorophenyl)-
2-(2,4-difluorophenyl)oxiranyl]methyl}-1H-1,2,4-triazole (13422606), (16.36) 2-fluoro(trifluoro-
methyl)-N-(1,1,3-trimethyl-2,3-dihydro-1H-indenyl)benzamide, (16.37) 2-fluoro(trifluoromethyl)-N-
[(3R)-1,1,3-trimethyl-2,3-dihydro-1H-indenyl]benzamide and (16.38) 2-fluoro(trifluoromethyl)-N-[(3S)-
1,1,3-trimethyl-2,3-dihydro-1H-indenyl]benzamide, and salts thereof.
Component (B) is preferably selected from the compounds mentioned in List L2:
cyproconazole (1130964), difenoconazole (1194463), epoxiconazole (1063250), fenhexamid
(1268338), fenpropidin (673067), fenpropimorph (673060), fluquinconazole (1364265), hex-
aconazole (799834), ipconazole (1252257), metconazole (1251166), myclobutanil (886710),
prochloraz (677475), propiconazole (602071), prothioconazole (1789286), spiroxamine (118134-
-8), tebuconazole (1075343), tetraconazole (1122813), triadimenol (894827), bixafen (581809-
46-03), boscalid (1884256), fluopyram (6580664), flutolanil (663325), isopyrazam (mixture of
syn-epimeric racemate 1RS,4SR,9RS and anti-epimeric racemate 1RS,4SR,9SR) (881651), isopyrazam
(syn epimeric racemate 1RS,4SR,9RS), isopyrazam (syn-epimeric enantiomer 1R,4S,9R), isopyrazam (syn-
epimeric enantiomer 1S,4R,9S), isopyrazam (anti-epimeric racemate 1RS,4SR,9SR), isopyrazam (anti-
epimeric enantiomer 1R,4S,9S), isopyrazam (anti-epimeric enantiomer 1S,4R,9R), penflufen (4947938),
penthiopyrad (1836753), sedaxane (8749676), 3-(difluoromethyl)methyl-N-[2-(1,1,2,2-
tetrafluoroethoxy)phenyl]-1H-pyrazolecarboxamide, 3-(difluoromethyl)-N-[4-fluoro(1,1,2,3,3,3-hexa-
fluoropropoxy)phenyl]methyl-1H-pyrazolecarboxamide, fluxapyroxad (9072043), benzovindiflupyr,
N-[1-(2,4-dichlorophenyl)methoxypropanyl](difluoromethyl)methyl-1H-pyrazole
carboxamide, ametoctradin (8653184), amisulbrom (3486350), azoxystrobin (1318608), cyazo-
famid (1201163), dimoxystrobin (1416004), enestroburin (2384102), fenamidone (161326
7), fluoxastrobin (3613779), kresoxim-methyl (1433900), metominostrobin (1334081), orysa-
strobin (1898921), picoxystrobin (1174285), pyraclostrobin (1750130), trifloxystrobin (141517-
21-7), pencycuron (660636), thiophanate-methyl (235648), fluopicolide (2391107), thiophanate
(235649), bordeaux mixture (80110), chlorothalonil (18976), dithianon (33476), dodine
(24393), folpet (1333), guazatine, copper oxide (13171), copper oxychloride (13327), copper
hydroxide (204272), copper sulfate (77587), mancozeb (80187), maneb (124272), oxine-
copper (103806), propineb (120719), sulfur and sulfur preparations including calcium polysulfide, thi-
ram (1378), copper naphthenate (13389), isotianil (2240491), cyprodinyl (1215522), pyrime-
thanil (531120), benthiavalicarb (1774067), dimethomorph (1104885), iprovalicarb (140923
7), mandipropamid (3747262), propamocarb (256061), propamocarb-hydrochloride (256061),
tricyclazole (418142), benalaxyl (716264), benalaxyl-M (kiralaxyl) (982435), metalaxyl
(578371), metalaxyl-M (mefenoxam) (706300), fludioxonil (1313411), iprodione (367347),
vinclozolin (504718), fluazinam (796226), meptyldinocap (1316), fosetyl-Al (391488), me-
trafenone (2208996), propamocarb-fosetylate, proquinazid (1892784), N-methyl(1-{[5-methyl
(trifluoromethyl)-1H-pyrazolyl]acetyl}piperidinyl)-N-[(1R)-1,2,3,4-tetrahydronaphthalenyl]-1,3-
thiazolecarboxamide (9225146), N-methyl(1-{[5-methyl(trifluoromethyl)-1H-pyrazol
yl]acetyl}piperidinyl)-N-(1,2,3,4-tetrahydronaphthalenyl)-1,3-thiazolecarboxamide (9225146), 1-
(4-{4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazolyl]-1,3-thiazolyl}piperidinyl)[5-methyl
(trifluoromethyl)-1H-pyrazolyl]ethanone (10033189) and 2-butoxyiodopropyl-4H-chromenone,
N'-(4-{[3-(4-chlorobenzyl)-1,2,4-thiadiazolyl]oxy}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide and
salts thereof.
Component (B) is more preferably selected from the compounds mentioned in List L3:
cyproconazole (1130964), epoxiconazole (1063250), fenhexamid (1268338), metconazole
(1251166), propiconazole (602071), prothioconazole (1789286), spiroxamine (1181348), te-
buconazole (1075343), bixafen (58180903), fluopyram (6580664), isopyrazam (mixture of syn-
epimeric racemate 1RS,4SR,9RS and anti-epimeric racemate 1RS,4SR,9SR) (881651), isopyrazam (syn
epimeric racemate 1RS,4SR,9RS), isopyrazam (syn-epimeric enantiomer 1R,4S,9R), isopyrazam (syn-epimeric
enantiomer 1S,4R,9S), isopyrazam (anti-epimeric racemate 1RS,4SR,9SR), isopyrazam (anti-epimeric enan-
tiomer 1R,4S,9S), isopyrazam (anti-epimeric enantiomer 1S,4R,9R), penflufen (4947938), penthiopyrad
(1836753), sedaxane (8749676), fluxapyroxad (9072043), benzovindiflupyr, N-[1-(2,4-
dichlorophenyl)methoxypropanyl](difluoromethyl)methyl-1H-pyrazolecarboxamide, ame-
toctradin (8653184), azoxystrobin (1318608), fluoxastrobin (3613779), pyraclostrobin (175013-
18-0), trifloxystrobin (1415177), fluopicolide (2391107), chlorothalonil (18976), folpet (133
3), mancozeb (80187), propineb (120719), isotianil (2240491), pyrimethanil (531120), ipro-
valicarb (1409237), propamocarb (256061), metalaxyl (578371), metalaxyl-M (mefenoxam)
(706300), fludioxonil (1313411) and fosetyl-Al (391488), N'-(4-{[3-(4-chlorobenzyl)-1,2,4-
thiadiazolyl]oxy}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide and salts thereof.
A preferred embodiment is directed to mixtures comprising the compound A1 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A2 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A3 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A4 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A5 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A6 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A7 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A8 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A9 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A10 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A11 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A12 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A13 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A14 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A15 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A16 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A17 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A18 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A19 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A preferred embodiment is directed to mixtures comprising the compound A20 as compound of formula (I)
and one compound selected from the compounds listed in List L1, in List L2 or in List L3.
A particular embodiment, is directed to mixtures consisting of one compound selected from the list consist-
ing of A1, A2, A3, A4, A5, A6, A7, A8, A9, A10, A11, A12, A13, A14, A15, A16, A17, A18, A19, and
A20, and of one compound selected from the compounds listed in List L1, in List L2 or in List L3.
If the active compounds in the active compound combinations described herein are present in certain weight
ratios, the synergistic effect is particularly pronounced. However, the weight ratios of the active compounds
in the active compound combinations can be varied within a relatively wide range.
In the combinations described herein the compounds (A) and (B) are present in a synergistically effective
weight ratio of A:B in a range of 1000:1 to 1:1000, preferably in a weight ratio of 100:1 to 1:100, more prefer-
ably in a weight ratio of 50:1 to 1:50, even more preferably in a weight ratio of 20:1 to 1:20. Further ratios of
A:B which can be useful in the present invention with increasing preference in the order given are: 95:1 to
1:95, 90:1 to 1:90, 85:1 to 1:85, 80:1 to 1:80, 75:1 to 1:75, 70:1 to 1:70, 65:1 to 1:65, 60:1 to 1:60, 55:1 to 1:55,
45:1 to 1:45, 40:1 to 1:40, 35:1 to 1:35, 30:1 to 1:30, 25:1 to 1:25, 15:1 to 1:15, 10:1 to 1:10, 5:1 to 1:5, 4:1 to
1:4, 3:1 to 1:3, 2:1 to 1:2.
Where a compound (A) or a compound (B) can be present in tautomeric form, such a compound is unders-
tood hereinabove and hereinbelow also to include, where applicable, corresponding tautomeric forms, even
when these are not specifically mentioned in each case.
Compounds (A) or compounds (B) having at least one basic centre are capable of forming, for example, ac-
id addition salts, e.g. with strong inorganic acids, such as mineral acids, e.g. perchloric acid, sulfuric acid,
nitric acid, nitrous acid, a phosphoric acid or a hydrohalic acid, with strong organic carboxylic acids, such as
unsubstituted substituted, e.g. halo-substituted, C -C -alkanecarboxylic acids, e.g. acetic acid, saturated or
unsaturated dicarboxylic acids, e.g. oxalic, malonic, succinic, maleic, fumaric and phthalic acid, hydrox-
ycarboxylic acids, e.g. ascorbic, lactic, malic, tartaric and citric acid, or benzoic acid, or with organic sulfon-
ic acids, such as unsubstituted or substituted, e.g. halo-substituted, C -C -alkane- or arylsulfonic acids, e.g.
methane- or p-toluene-sulfonic acid. Compounds (A) or compounds (B) having at least one acid group are
capable of forming, for example, salts with bases, e.g. metal salts, such as alkali metal or alkaline earth met-
al salts, e.g. sodium, potassium or magnesium salts, or salts with ammonia or an organic amine, such as
morpholine, piperidine, pyrrolidine, a mono-, di- or tri-lower alkylamine, e.g. ethyl-, diethyl-, triethyl- or
dimethyl-propyl-amine, or a mono-, di- or tri-hydroxy-lower alkylamine, e.g. mono-, di- or tri-ethanolamine.
In addition, corresponding internal salts may optionally be formed. In the present context, preference is giv-
en to agrochemically advantageous salts. In view of the close relationship between the compounds (A) or
the compounds (B) in free form and in the form of their salts, hereinabove and herein below any reference
to the free compounds (A) or free compounds (B) or to their salts should be understood as including also the
corresponding salts or the free compounds (A) or free compounds (B), respectively, where appropriate and
expedient. The equivalent also applies to tautomers of compounds (A) or compounds (B) and to their salts.
As used herein the expression “combination” stands for the various combinations of compounds (A) and
(B), for example in a single “ready-mix” form, in a combined spray mixture composed from separate formu-
lations of the single active compounds, such as a “tank-mix”, and in a combined use of the single active in-
gredients when applied in a sequential manner, i.e. one after the other with a reasonably short period, such
as a few hours or days. Preferably the order of applying the compounds (A) and (B) is not essential for
working the present invention.
Also described are compositions for combating/controlling undesirable microorganisms comprising the ac-
tive compound combinations described herein. Preferably, the compositions are fungicidal compositions
comprising agriculturally suitable auxiliaries, solvents, carriers, surfactants or extenders.
Also described is a method of combating undesirable microorganisms, characterized in that the active com-
pound combinations described herein are applied to the phytopathogenic fungi and/or their habitat.
As used herein, carrier is to be understood as meaning a natural or synthetic, organic or inorganic substance
which is mixed or combined with the active compounds for better applicability, in particular for application
to plants or plant parts or seeds. The carrier, which may be solid or liquid, is generally inert and should be
suitable for use in agriculture.
Suitable solid or liquid carriers are: for example ammonium salts and natural ground minerals, such as kao-
lins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic
minerals, such as finely divided silica, alumina and natural or synthetic silicates, resins, waxes, solid ferti-
lizers, water, alcohols, especially butanol, organic solvents, mineral oils and vegetable oils, and also deriva-
tives thereof. It is also possible to use mixtures of such carriers. Solid carriers suitable for granules are: for
example crushed and fractionated natural minerals, such as calcite, marble, pumice, sepiolite, dolomite, and
also synthetic granules of inorganic and organic meals and also granules of organic material, such as saw-
dust, coconut shells, maize cobs and tobacco stalks.
Suitable liquefied gaseous extenders or carriers are liquids which are gaseous at ambient temperature and
under atmospheric pressure, for example aerosol propellants, such as butane, propane, nitrogen and carbon
dioxide.
Tackifiers, such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, gra-
nules and latices, such as gum arabic, polyvinyl alcohol, polyvinyl acetate, or else natural phospholipids,
such as cephalins and lecithins and synthetic phospholipids can be used in the formulations. Other possible
additives are mineral and vegetable oils and waxes, optionally modified.
If the extender used is water, it is also possible for example, to use organic solvents as auxiliary solvents.
Suitable liquid solvents are essentially: aromatic compounds, such as xylene, toluene or alkylnaphthalenes,
chlorinated aromatic compounds or chlorinated aliphatic hydrocarbons, such as chlorobenzenes, chloroethy-
lenes or methylene chloride, aliphatic hydrocarbons, such as cyclohexane or paraffins, for example mineral
oil fractions, mineral and vegetable oils, alcohols, such as butanol or glycol, and also ethers and esters the-
reof, ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar
solvents, such as dimethylformamide and dimethyl sulfoxide, and also water.
The compositions according to the invention may comprise additional further components, such as, for ex-
ample, surfactants. Suitable surfactants are emulsifiers, dispersants or wetting agents having ionic or nonio-
nic properties, or mixtures of these surfactants. Examples of these are salts of polyacrylic acid, salts of lig-
nosulfonic acid, salts of phenolsulfonic acid or naphthalenesulfonic acid, polycondensates of ethylene oxide
with fatty alcohols or with fatty acids or with fatty amines, substituted phenols (preferably alkylphenols or
arylphenols), salts of sulfosuccinic esters, taurine derivatives (preferably alkyl taurates), phosphoric esters
of polyethoxylated alcohols or phenols, fatty esters of polyols, and derivatives of the compounds containing
sulfates, sulfonates and phosphates. The presence of a surfactant is required if one of the active compounds
and/or one of the inert carriers is insoluble in water and when the application takes place in water. The pro-
portion of surfactants is between 5 and 40 per cent by weight of the composition according to the invention.
It is possible to use colorants such as inorganic pigments, for example iron oxide, titanium oxide, Prussian
blue, and organic dyes, such as alizarin dyes, azo dyes and metal phthalocyanine dyes, and trace nutrients,
such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.
If appropriate, other additional components may also be present, for example protective colloids, binders,
adhesives, thickeners, thixotropic substances, penetrants, stabilizers, sequestering agents, complex formers.
In general, the active compounds can be combined with any solid or liquid additive customarily used for
formulation purposes.
In general, the compositions according to the invention comprise between 0.05 and 99 per cent by weight,
0.01 and 98 per cent by weight, preferable between 0.1 and 95 per cent by weight, particularly preferred be-
tween 0.5 and 90 per cent by weight of the active compound combination described herein , very particular-
ly preferable between 10 and 70 per cent by weight.
The active compound combinations described herein or compositions according to the invention can be used as
such or, depending on their respective physical and/or chemical properties, in the form of their formulations or
the use forms prepared therefrom, such as aerosols, capsule suspensions, cold-fogging concentrates, warm-
fogging concentrates, encapsulated granules, fine granules, flowable concentrates for the treatment of seed,
ready-to-use solutions, dustable powders, emulsifiable concentrates, oil-in-water emulsions, water-in-oil emul-
sions, macrogranules, microgranules, oil-dispersible powders, oil-miscible flowable concentrates, oil-miscible
liquids, foams, pastes, pesticide-coated seed, suspension concentrates, suspoemulsion concentrates, soluble
concentrates, suspensions, wettable powders, soluble powders, dusts and granules, water-soluble granules or
tablets, water-soluble powders for the treatment of seed, wettable powders, natural products and synthetic sub-
stances impregnated with active compound, and also microencapsulations in polymeric substances and in coat-
ing materials for seed, and also ULV cold-fogging and warm-fogging formulations.
The formulations mentioned can be prepared in a manner known per se, for example by mixing the active
compounds or the active compound combinations with at least one additive. Suitable additives are all customa-
ry formulation auxiliaries, such as, for example, organic solvents, extenders, solvents or diluents, solid carriers
and fillers, surfactants (such as adjuvants, emulsifiers, dispersants, protective colloids, wetting agents and tack-
ifiers), dispersants and/or binders or fixatives, preservatives, dyes and pigments, defoamers, inorganic and or-
ganic thickeners, water repellents, if appropriate siccatives and UV stabilizers, gibberellins and also water and
further processing auxiliaries. Depending on the formulation type to be prepared in each case, further
processing steps such as, for example, wet grinding, dry grinding or granulation may be required.
The compositions according to the invention do not only comprise ready-to-use compositions which can be
applied with suitable apparatus to the plant or the seed, but also commercial concentrates which have to be
diluted with water prior to use.
The active compound combinations described herein can be present in (commercial) formulations and in the
use forms prepared from these formulations as a mixture with other (known) active compounds, such as in-
secticides, attractants, sterilants, bactericides, acaricides, nematicides, fungicides, growth regulators, herbi-
cides, fertilizers, safeners and Semiochemicals.
The treatment of the plants and plant parts with the active compounds or compositions is carried out directly
or by action on their surroundings, habitat or storage space using customary treatment methods, for example
by dipping, spraying, atomizing, irrigating, evaporating, dusting, fogging, broadcasting, foaming, painting,
spreading-on, watering (drenching), drip irrigating and, in the case of propagation material, in particular in
the case of seeds, furthermore as a powder for dry seed treatment, a solution for seed treatment, a water-
soluble powder for slurry treatment, by incrusting, by coating with one or more layers, etc. It is furthermore
possible to apply the active compounds by the ultra-low volume method, or to inject the active compound
preparation or the active compound itself into the soil.
Also described is a method for treating seed. Also described is seed treated according to one of the methods
described in the preceding paragraph.
The active compounds described herein or compositions according to the invention are especially suitable
for treating seed. A large part of the damage to crop plants caused by harmful organisms is triggered by an
infection of the seed during storage or after sowing as well as during and after germination of the plant. This
phase is particularly critical since the roots and shoots of the growing plant are particularly sensitive, and
even small damage may result in the death of the plant. Accordingly, there is great interest in protecting the
seed and the germinating plant by using appropriate compositions.
The control of phytopathogenic fungi by treating the seed of plants has been known for a long time and is the
subject of continuous improvements. However, the treatment of seed entails a series of problems which cannot
always be solved in a satisfactory manner. Thus, it is desirable to develop methods for protecting the seed and
the germinating plant which dispense with the additional application of crop protection agents after sowing or
after the emergence of the plants or which at least considerably reduce additional application. It is furthermore
desirable to optimize the amount of active compound employed in such a way as to provide maximum protec-
tion for the seed and the germinating plant from attack by phytopathogenic fungi, but without damaging the
plant itself by the active compound employed. In particular, methods for the treatment of seed should also take
into consideration the intrinsic fungicidal properties of transgenic plants in order to achieve optimum protec-
tion of the seed and the germinating plant with a minimum of crop protection agents being employed.
Accordingly, also described is a method for protecting seed and germinating plants against attack by phyto-
pathogenic fungi by treating the seed with a composition according to the invention. The invention also re-
lates to the use of the compositions according to the invention for treating seed for protecting the seed and
the germinating plant against phytopathogenic fungi. Also described are seed treated with a composition ac-
cording to the invention for protection against phytopathogenic fungi.
The control of phytopathogenic fungi which damage plants post-emergence is carried out primarily by treating
the soil and the above-ground parts of plants with crop protection compositions. Owing to the concerns regard-
ing a possible impact of the crop protection composition on the environment and the health of humans and an-
imals, there are efforts to reduce the amount of active compounds applied.
One of the advantages of the present invention is that, because of the particular systemic properties of the
compositions according to the invention, treatment of the seed with these compositions not only protects the
seed itself, but also the resulting plants after emergence, from phytopathogenic fungi. In this manner, the
immediate treatment of the crop at the time of sowing or shortly thereafter can be dispensed with.
It is also considered to be advantageous that the mixtures described herein can be used in particular also for
transgenic seed where the plant growing from this seed is capable of expressing a protein which acts against
pests. By treating such seed with the active compound combinations as described herein or compositions
according to the invention, even by the expression of the, for example, insecticidal protein, certain pests
may be controlled. Surprisingly, a further synergistic effect may be observed here, which additionally in-
creases the effectiveness of the protection against attack by pests.
The compositions according to the invention are suitable for protecting seed of any plant variety employed
in agriculture, in the greenhouse, in forests or in horticulture or viticulture. In particular, this takes the form
of seed of cereals (such as wheat, barley, rye, triticale, millet, oats), maize (corn), cotton, soya bean, rice,
potatoes, sunflowers, beans, coffee, beets (e.g. sugar beets and fodder beets), peanuts, oilseed rape, poppies,
olives, coconuts, cacao, sugar cane, tobacco, vegetables (such as tomatoes, cucumbers, onions and lettuce),
lawn and ornamental plants (also see below). The treatment of seeds of cereals (such as wheat, barley, rye,
triticale, and oats), maize (corn) and rice is of particular importance.
According to the invention all plants and plant parts can be treated. By plants is meant all plants and plant
populations such as desirable and undesirable wild plants, cultivars and plant varieties (whether or not pro-
tectable by plant variety or plant breeder’s rights). Cultivars and plant varieties can be plants obtained by
conventional propagation and breeding methods which can be assisted or supplemented by one or more
biotechnological methods such as by use of double haploids, protoplast fusion, random and directed muta-
genesis, molecular or genetic markers or by bioengineering and genetic engineering methods. By plant
parts is meant all above ground and below ground parts and organs of plants such as shoot, leaf, blossom
and root, whereby for example leaves, needles, stems, branches, blossoms, fruiting bodies, fruits and seed
as well as roots, corms and rhizomes are listed. Crops and vegetative and generative propagating material,
for example cuttings, corms, rhizomes, runners and seeds also belong to plant parts.
Among the plants that can be protected by the method, mention may be made of major field crops like corn,
soybean, cotton, Brassica oilseeds such as Brassica napus (e.g. canola), Brassica rapa, B. juncea (e.g. mus-
tard) and Brassica carinata, rice, wheat, sugarbeet, sugarcane, oats, rye, barley, millet, triticale, flax, vine and
various fruits and vegetables of various botanical taxa such as Rosaceae sp. (for instance pip fruit such as ap-
ples and pears, but also stone fruit such as apricots, cherries, almonds and peaches, berry fruits such as straw-
berries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp.,
Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for instance banana trees and plantings), Rubia-
ceae sp. (for instance coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for instance lemons, oranges and
grapefruit) ; Solanaceae sp. (for instance tomatoes, potatoes, peppers, eggplant), Liliaceae sp., Compositiae sp.
(for instance lettuce, artichoke and chicory - including root chicory, endive or common chicory), Umbelliferae
sp. (for instance carrot, parsley, celery and celeriac), Cucurbitaceae sp. (for instance cucumber – including
pickling cucumber, squash, watermelon, gourds and melons), Alliaceae sp. (for instance onions and leek), Cru-
ciferae sp. (for instance white cabbage, red cabbage, broccoli, cauliflower, brussel sprouts, pak choi, kohlrabi,
radish, horseradish, cress, Chinese cabbage), Leguminosae sp. (for instance peanuts, peas and beans beans -
such as climbing beans and broad beans), Chenopodiaceae sp. (for instance mangold, spinach beet, spinach,
beetroots), Malvaceae (for instance okra), Asparagaceae (for instance asparagus); horticultural and forest
crops; ornamental plants; as well as genetically modified homologues of these crops.
The method of treatment can be used in the treatment of genetically modified organisms (GMOs), e.g. plants or
seeds. Genetically modified plants (or transgenic plants) are plants of which a heterologous gene has been stab-
ly integrated into genome. The expression “heterologous gene” essentially means a gene which is provided or
assembled outside the plant and when introduced in the nuclear, chloroplastic or mitochondrial genome gives
the transformed plant new or improved agronomic or other properties by expressing a protein or polypeptide of
interest or by downregulating or silencing other gene(s) which are present in the plant (using for example, anti-
sense technology, cosuppression technology or RNA interference – RNAi - technology). A heterologous gene
that is located in the genome is also called a transgene. A transgene that is defined by its particular location in
the plant genome is called a transformation or transgenic event.
Depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vege-
tation period, diet), the treatment may also result in superadditive (“synergistic”) effects. Thus, for example,
reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the
active compounds and compositions which can be used as described herein, better plant growth, increased
tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, in-
creased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, bigger
fruits, larger plant height, greener leaf color, earlier flowering, higher quality and/or a higher nutritional value
of the harvested products, higher sugar concentration within the fruits, better storage stability and/or proces-
sability of the harvested products are possible, which exceed the effects which were actually to be expected.
At certain application rates, the active compound combinations may also have a strengthening effect in
plants. Accordingly, they are also suitable for mobilizing the defense system of the plant against attack by
unwanted microorganisms. This may, if appropriate, be one of the reasons of the enhanced activity of the
combinations, for example against fungi. Plant-strengthening (resistance-inducing) substances are to be
understood as meaning, in the present context, those substances or combinations of substances which are
capable of stimulating the defense system of plants in such a way that, when subsequently inoculated with
unwanted microorganisms, the treated plants display a substantial degree of resistance to these
microorganisms. In the present case, unwanted microorganisms are to be understood as meaning
phytopathogenic fungi, bacteria and viruses. Thus, the substances described herein can be employed for
protecting plants against attack by the abovementioned pathogens within a certain period of time after the
treatment. The period of time within which protection is effected generally extends from 1 to 10 days,
preferably 1 to 7 days, after the treatment of the plants with the active compounds.
Plants and plant cultivars which are preferably to be treated as described herein include all plants which
have genetic material which impart particularly advantageous, useful traits to these plants (whether obtained
by breeding and/or biotechnological means).
Plants and plant cultivars which are also preferably to be treated as described herein are resistant against one
or more biotic stresses, i.e. said plants show a better defense against animal and microbial pests, such as
against nematodes, insects, mites, phytopathogenic fungi, bacteria, viruses and/or viroids.
Examples of nematode resistant plants are described in e.g. US Patent Application Nos 11/765,491,
11/765,494, 10/926,819, 10/782,020, 12/032,479, 10/783,417, 10/782,096, 11/657,964, 12/192,904,
11/396,808, 12/166,253, 12/166,239, 12/166,124, 12/166,209, 11/762,886, 12/364,335, 11/763,947,
12/252,453, 12/209,354, 12/491,396 or 12/497,221.
Plants and plant cultivars which may also be treated as described herein are those plants which are resistant
to one or more abiotic stresses. Abiotic stress conditions may include, for example, drought, cold tempera-
ture exposure, heat exposure, osmotic stress, flooding, increased soil salinity, increased mineral exposure,
ozone exposure, high light exposure, limited availability of nitrogen nutrients, limited availability of phos-
phorus nutrients, shade avoidance.
Plants and plant cultivars which may also be treated as described herein, are those plants characterized by
enhanced yield characteristics. Increased yield in said plants can be the result of, for example, improved
plant physiology, growth and development, such as water use efficiency, water retention efficiency, im-
proved nitrogen use, enhanced carbon assimilation, improved photosynthesis, increased germination effi-
ciency and accelerated maturation. Yield can furthermore be affected by improved plant architecture (under
stress and non-stress conditions), including but not limited to, early flowering, flowering control for hybrid
seed production, seedling vigor, plant size, internode number and distance, root growth, seed size, fruit size,
pod size, pod or ear number, seed number per pod or ear, seed mass, enhanced seed filling, reduced seed
dispersal, reduced pod dehiscence and lodging resistance. Further yield traits include seed composition,
such as carbohydrate content, protein content, oil content and composition, nutritional value, reduction in
anti-nutritional compounds, improved processability and better storage stability.
Plants that may be treated as described herein are hybrid plants that already express the characteristic of he-
terosis or hybrid vigor which results in generally higher yield, vigor, health and resistance towards biotic
and abiotic stresses). Such plants are typically made by crossing an inbred male-sterile parent line (the fe-
male parent) with another inbred male-fertile parent line (the male parent). Hybrid seed is typically har-
vested from the male sterile plants and sold to growers. Male sterile plants can sometimes (e.g. in corn) be
produced by detasseling, i.e. the mechanical removal of the male reproductive organs (or males flowers)
but, more typically, male sterility is the result of genetic determinants in the plant genome. In that case, and
especially when seed is the desired product to be harvested from the hybrid plants it is typically useful to
ensure that male fertility in the hybrid plants is fully restored. This can be accomplished by ensuring that the
male parents have appropriate fertility restorer genes which are capable of restoring the male fertility in hy-
brid plants that contain the genetic determinants responsible for male-sterility. Genetic determinants for
male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) were for in-
stance described in Brassica species (WO 92/05251, WO 95/09910, WO 98/27806, WO 05/002324, WO
06/021972 and US 6,229,072). However, genetic determinants for male sterility can also be located in the
nuclear genome. Male sterile plants can also be obtained by plant biotechnology methods such as genetic
engineering. A particularly useful means of obtaining male-sterile plants is described in WO 89/10396 in
which, for example, a ribonuclease such as barnase is selectively expressed in the tapetum cells in the sta-
mens. Fertility can then be restored by expression in the tapetum cells of a ribonuclease inhibitor such as
barstar (e.g. WO 91/02069).
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may
be treated as described herein are herbicide-tolerant plants, i.e. plants made tolerant to one or more given
herbicides. Such plants can be obtained either by genetic transformation, or by selection of plants containing
a mutation imparting such herbicide tolerance.
Herbicide-resistant plants are for example glyphosate-tolerant plants, i.e. plants made tolerant to the herbi-
cide glyphosate or salts thereof. Plants can be made tolerant to glyphosate through different means. For ex-
ample, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the en-
zyme 5-enolpyruvylshikimatephosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA
gene (mutant CT7) of the bacterium Salmonella typhimurium (Comai et al., 1983, Science 221, 370-371),
the CP4 gene of the bacterium Agrobacterium sp. (Barry et al., 1992, Curr. Topics Plant Physiol. 7, 139-
145), the genes encoding a Petunia EPSPS (Shah et al., 1986, Science 233, 478-481), a Tomato EPSPS
(Gasser et al., 1988, J. Biol. Chem. 263, 4280-4289), or an Eleusine EPSPS (WO 01/66704). It can also be a
mutated EPSPS as described in for example EP 0837944, WO 00/66746, WO 00/66747 or WO 02/26995.
Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate oxido-
reductase enzyme as described in U.S. Patent Nos. 5,776,760 and 5,463,175. Glyphosate-tolerant plants can
also be obtained by expressing a gene that encodes a glyphosate acetyl transferase enzyme as described in
for example WO 02/36782, WO 03/092360, WO 05/012515 and WO 07/024782. Glyphosate-tolerant plants
can also be obtained by selecting plants containing naturally-occurring mutations of the above-mentioned
genes, as described in for example WO 01/024615 or WO 03/013226. Plants expressing EPSPS genes that
confer glyphosate tolerance are described in e.g. US Patent Application Nos 11/517,991, 10/739,610,
12/139,408, 12/352,532, 11/312,866, 11/315,678, 12/421,292, 11/400,598, 11/651,752, 11/681,285,
11/605,824, 12/468,205, 11/760,570, 11/762,526, 11/769,327, 11/769,255, 11/943801 or 12/362,774. Plants
comprising other genes that confer glyphosate tolerance, such as decarboxylase genes, are described in e.g.
US patent applications 11/588,811, 11/185,342, 12/364,724, 11/185,560 or 12/423,926.
Other herbicide resistant plants are for example plants that are made tolerant to herbicides inhibiting the en-
zyme glutamine synthase, such as bialaphos, phosphinothricin or glufosinate. Such plants can be obtained
by expressing an enzyme detoxifying the herbicide or a mutant glutamine synthase enzyme that is resistant
to inhibition, e.g. described in US Patent Application No 11/760,602. One such efficient detoxifying en-
zyme is an enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat protein from Strep-
tomyces species). Plants expressing an exogenous phosphinothricin acetyltransferase are for example de-
scribed in U.S. Patent Nos. 5,561,236; 5,648,477; 5,646,024; 5,273,894; 5,637,489; 5,276,268; 5,739,082;
,908,810 and 7,112,665.
Further herbicide-tolerant plants are also plants that are made tolerant to the herbicides inhibiting the en-
zyme hydroxyphenylpyruvatedioxygenase (HPPD). Hydroxyphenylpyruvatedioxygenases are enzymes that
catalyze the reaction in which para-hydroxyphenylpyruvate (HPP) is transformed into homogentisate. Plants
tolerant to HPPD-inhibitors can be transformed with a gene encoding a naturally-occurring resistant HPPD
enzyme, or a gene encoding a mutated or chimeric HPPD enzyme as described in WO 96/38567, WO
99/24585, WO 99/24586, , , or US 6,768,044.. Tolerance to HPPD-
inhibitors can also be obtained by transforming plants with genes encoding certain enzymes enabling the
formation of homogentisate despite the inhibition of the native HPPD enzyme by the HPPD-inhibitor. Such
plants and genes are described in WO 99/34008 and WO 02/36787. Tolerance of plants to HPPD inhibitors
can also be improved by transforming plants with a gene encoding an enzyme having prephenate deshydro-
genase (PDH) activity in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO
2004/024928. Further, plants can be made more tolerant to HPPD-inhibitor herbicides by adding into their
genome a gene encoding an enzyme capable of metabolizing or degrading HPPD inhibitors, such as the
CYP450 enzymes shown in and .
Still further herbicide resistant plants are plants that are made tolerant to acetolactate synthase (ALS) inhibi-
tors. Known ALS-inhibitors include, for example, sulfonylurea, imidazolinone, triazolopyrimidines, pryimi-
dinyoxy(thio)benzoates, and/or sulfonylaminocarbonyltriazolinone herbicides. Different mutations in the
ALS enzyme (also known as acetohydroxyacid synthase, AHAS) are known to confer tolerance to different
herbicides and groups of herbicides, as described for example in Tranel and Wright (2002, Weed Science
50:700-712), but also, in U.S. Patent No. 5,605,011, 5,378,824, 5,141,870, and 5,013,659. The production
of sulfonylurea-tolerant plants and imidazolinone-tolerant plants is described in U.S. Patent Nos. 5,605,011;
,013,659; 5,141,870; 5,767,361; 5,731,180; 5,304,732; 4,761,373; 5,331,107; 5,928,937; and 5,378,824;
and international publication WO 96/33270. Other imidazolinone-tolerant plants are also described in for
example , , , , ,
, , and . Further sulfonylurea- and imidazolinone-
tolerant plants are also described in for example WO 07/024782 and US Patent Application No 61/288958.
Other plants tolerant to imidazolinone and/or sulfonylurea can be obtained by induced mutagenesis, selec-
tion in cell cultures in the presence of the herbicide or mutation breeding as described for example for soy-
beans in U.S. Patent 5,084,082, for rice in WO 97/41218, for sugar beet in U.S. Patent 5,773,702 and WO
99/057965, for lettuce in U.S. Patent 5,198,599, or for sunflower in WO 01/065922.
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may
also be treated as described herein are insect-resistant transgenic plants, i.e. plants made resistant to attack
by certain target insects. Such plants can be obtained by genetic transformation, or by selection of plants
containing a mutation imparting such insect resistance.
An “insect-resistant transgenic plant”, as used herein, includes any plant containing at least one transgene
comprising a coding sequence encoding:
1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal portion thereof, such
as the insecticidal crystal proteins listed by Crickmore et al. (1998, Microbiology and Molecular
Biology Reviews, 62: 807-813), updated by Crickmore et al. (2005) at the Bacillus thuringiensis
toxin nomenclature, online at:
http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or insecticidal portions thereof, e.g.,
proteins of the Cry protein classes Cry1Ab, Cry1Ac, Cry1B, Cry1C, Cry1D, Cry1F, Cry2Ab,
Cry3Aa, or Cry3Bb or insecticidal portions thereof (e.g. EP 1999141 and ), or
such proteins encoded by synthetic genes as e.g. described in and US Patent Application No
12/249,016 ; or
2) a crystal protein from Bacillus thuringiensis or a portion thereof which is insecticidal in the pres-
ence of a second other crystal protein from Bacillus thuringiensis or a portion thereof, such as the
binary toxin made up of the Cry34 and Cry35 crystal proteins (Moellenbeck et al. 2001, Nat. Bio-
technol. 19: 668-72; Schnepf et al. 2006, Applied Environm. Microbiol. 71, 1765-1774) or the bi-
nary toxin made up of the Cry1A or Cry1F proteins and the Cry2Aa or Cry2Ab or Cry2Ae proteins
(US Patent Appl. No. 12/214,022 and EP 08010791.5); or
3) a hybrid insecticidal protein comprising parts of different insecticidal crystal proteins from Bacil-
lus thuringiensis, such as a hybrid of the proteins of 1) above or a hybrid of the proteins of 2)
above, e.g., the Cry1A.105 protein produced by corn event MON89034 (); or
4) a protein of any one of 1) to 3) above wherein some, particularly 1 to 10, amino acids have been
replaced by another amino acid to obtain a higher insecticidal activity to a target insect species,
and/or to expand the range of target insect species affected, and/or because of changes introduced
into the encoding DNA during cloning or transformation, such as the Cry3Bb1 protein in corn
events MON863 or MON88017, or the Cry3A protein in corn event MIR604; or
) an insecticidal secreted protein from Bacillus thuringiensis or Bacillus cereus, or an insecticidal
portion thereof, such as the vegetative insecticidal (VIP) proteins listed at:
http://www.lifesci.sussex.ac.uk/home/Neil_Crickmore/Bt/vip.html, e.g., proteins from the VIP3Aa
protein class; or
6) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the
presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary
toxin made up of the VIP1A and VIP2A proteins (WO 94/21795); or
7) a hybrid insecticidal protein comprising parts from different secreted proteins from Bacillus thu-
ringiensis or Bacillus cereus, such as a hybrid of the proteins in 1) above or a hybrid of the proteins
in 2) above; or
8) a protein of any one of 5) to 7) above wherein some, particularly 1 to 10, amino acids have been
replaced by another amino acid to obtain a higher insecticidal activity to a target insect species,
and/or to expand the range of target insect species affected, and/or because of changes introduced
into the encoding DNA during cloning or transformation (while still encoding an insecticidal pro-
tein), such as the VIP3Aa protein in cotton event COT102; or
9) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the
presence of a crystal protein from Bacillus thuringiensis, such as the binary toxin made up of VIP3
and Cry1A or Cry1F (US Patent Appl. No. 61/126083 and 61/195019), or the binary toxin made up
of the VIP3 protein and the Cry2Aa or Cry2Ab or Cry2Ae proteins (US Patent Appl. No.
12/214,022 and EP 08010791.5).
) a protein of 9) above wherein some, particularly 1 to 10, amino acids have been replaced by
another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to ex-
pand the range of target insect species affected, and/or because of changes introduced into the en-
coding DNA during cloning or transformation (while still encoding an insecticidal protein)
Of course, an insect-resistant transgenic plant, as used herein, also includes any plant comprising a combina-
tion of genes encoding the proteins of any one of the above classes 1 to 10. In one embodiment, an insect-
resistant plant contains more than one transgene encoding a protein of any one of the above classes 1 to 10,
to expand the range of target insect species affected when using different proteins directed at different target
insect species, or to delay insect resistance development to the plants by using different proteins insecticidal
to the same target insect species but having a different mode of action, such as binding to different receptor
binding sites in the insect.
An “insect-resistant transgenic plant”, as used herein, further includes any plant containing at least one
transgene comprising a sequence producing upon expression a double-stranded RNA which upon ingestion
by a plant insect pest inhibits the growth of this insect pest, as described e.g. in , WO
2006/129204, , and .
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may
also be treated as described herein are tolerant to abiotic stresses. Such plants can be obtained by genetic
transformation, or by selection of plants containing a mutation imparting such stress resistance. Particularly
useful stress tolerance plants include:
1) plants which contain a transgene capable of reducing the expression and/or the activity of
poly(ADP-ribose) polymerase (PARP) gene in the plant cells or plants as described in WO
00/04173, WO/2006/045633, EP 04077984.5, or EP 06009836.5.
2) plants which contain a stress tolerance enhancing transgene capable of reducing the expression
and/or the activity of the PARG encoding genes of the plants or plants cells, as described e.g. in
3) plants which contain a stress tolerance enhancing transgene coding for a plant-functional enzyme
of the nicotineamide adenine dinucleotide salvage synthesis pathway including nicotinamidase, ni-
cotinate phosphoribosyltransferase, nicotinic acid mononucleotide adenyl transferase, nicotinamide
adenine dinucleotide synthetase or nicotine amide phosphorybosyltransferase as described e.g. in
EP 04077624.7, , PCT/EP07/002433, EP 1999263, or .
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which
may also be treated as described herein show altered quantity, quality and/or storage-stability of the har-
vested product and/or altered properties of specific ingredients of the harvested product such as :
1) transgenic plants which synthesize a modified starch, which in its physical-chemical characteris-
tics, in particular the amylose content or the amylose/amylopectin ratio, the degree of branching, the
average chain length, the side chain distribution, the viscosity behaviour, the gelling strength, the
starch grain size and/or the starch grain morphology, is changed in comparison with the synthesised
starch in wild type plant cells or plants, so that this is better suited for special applications. Said
transgenic plants synthesizing a modified starch are disclosed, for example, in EP 0571427, WO
95/04826, EP 0719338, WO 96/15248, WO 96/19581, WO 96/27674, WO 97/11188, WO
97/26362, WO 97/32985, WO 97/42328, WO 97/44472, WO 97/45545, WO 98/27212, WO
98/40503, WO99/58688, WO 99/58690, WO 99/58654, WO 00/08184, WO 00/08185, WO
00/08175, WO 00/28052, WO 00/77229, WO 01/12782, WO 01/12826, WO 02/101059, WO
03/071860, , , , , WO
2005/095617, , , , , WO
2006/103107, , , WO 00/22140, , WO
2006/072603, WO 02/034923, EP 06090134.5, EP 06090228.5, EP 06090227.7, EP 07090007.1,
EP 07090009.7, WO 01/14569, WO 02/79410, WO 03/33540, , WO 01/19975,
WO 95/26407, WO 96/34968, WO 98/20145, WO 99/12950, WO 99/66050, WO 99/53072, US
6,734,341, WO 00/11192, WO 98/22604, WO 98/32326, WO 01/98509, WO 01/98509, WO
2005/002359, US 5,824,790, US 6,013,861, WO 94/04693, WO 94/09144, WO 94/11520, WO
95/35026, WO 97/20936
2) transgenic plants which synthesize non starch carbohydrate polymers or which synthesize non
starch carbohydrate polymers with altered properties in comparison to wild type plants without ge-
netic modification. Examples are plants producing polyfructose, especially of the inulin and levan-
type, as disclosed in EP 0663956, WO 96/01904, WO 96/21023, WO 98/39460, and WO 99/24593,
plants producing alpha-1,4-glucans as disclosed in WO 95/31553, US 2002031826, US 6,284,479,
US 5,712,107, WO 97/47806, WO 97/47807, WO 97/47808 and WO 00/14249, plants producing
alpha-1,6 branched alpha-1,4-glucans, as disclosed in WO 00/73422, plants producing alternan, as
disclosed in e.g. WO 00/47727, WO 00/73422, EP 06077301.7, US 5,908,975 and EP 0728213,
3) transgenic plants which produce hyaluronan, as for example disclosed in , WO
2007/039314, , , JP 2006304779, and .
4) transgenic plants or hybrid plants, such as onions with characteristics such as ‘high soluble solids
content’, ‘low pungency’ (LP) and/or ‘long storage’ (LS), as described in US Patent Appl. No.
12/020,360 and 61/054,026.
Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering)
which may also be treated as described herein are plants, such as cotton plants, with altered fiber characte-
ristics. Such plants can be obtained by genetic transformation, or by selection of plants contain a mutation
imparting such altered fiber characteristics and include:
a) Plants, such as cotton plants, containing an altered form of cellulose synthase genes as de-
scribed in WO 98/00549
b) Plants, such as cotton plants, containing an altered form of rsw2 or rsw3 homologous nucleic
acids as described in
c) Plants, such as cotton plants, with increased expression of sucrose phosphate synthase as de-
scribed in WO 01/17333
d) Plants, such as cotton plants, with increased expression of sucrose synthase as described in WO
02/45485
e) Plants, such as cotton plants, wherein the timing of the plasmodesmatal gating at the basis of
the fiber cell is altered, e.g. through downregulation of fiber-selective β-1,3-glucanase as de-
scribed in , or as described in EP 08075514.3 or US Patent Appl. No.
61/128,938
f) Plants, such as cotton plants, having fibers with altered reactivity, e.g. through the expression of
N-acetylglucosaminetransferase gene including nodC and chitin synthase genes as described in
Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering)
which may also be treated as described herein are plants, such as oilseed rape or related Brassica plants,
with altered oil profile characteristics. Such plants can be obtained by genetic transformation, or by selec-
tion of plants contain a mutation imparting such altered oil profile characteristics and include:
a) Plants, such as oilseed rape plants, producing oil having a high oleic acid content as described
e.g. in US 5,969,169, US 5,840,946 or US 6,323,392 or US 6,063,947
b) Plants such as oilseed rape plants, producing oil having a low linolenic acid content as de-
scribed in US 6,270,828, US 6,169,190, or US 5,965,755
c) Plant such as oilseed rape plants, producing oil having a low level of saturated fatty acids as de-
scribed e.g. in US Patent No. 5,434,283 or US Patent Application No 12/668303
Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering)
which may also be treated as described herein are plants, such as oilseed rape or related Brassica plants,
with altered seed shattering characteristics. Such plants can be obtained by genetic transformation, or by se-
lection of plants contain a mutation imparting such altered seed shattering characteristics and include plants
such as oilseed rape plants with delayed or reduced seed shattering as described in US Patent Appl. No.
61/135,230 WO09/068313 and WO10/006732.
Particularly useful transgenic plants which may be treated as described herein are plants containing trans-
formation events, or combination of transformation events, that are the subject of petitions for non-regulated
status, in the United States of America, to the Animal and Plant Health Inspection Service (APHIS) of the
United States Department of Agriculture (USDA) whether such petitions are granted or are still pending. At
any time this information is readily available from APHIS (4700 River Road Riverdale, MD 20737, USA),
for instance on its internet site (URL http://www.aphis.usda.gov/brs/not_reg.html). On the filing date of this
application the petitions for nonregulated status that were pending with APHIS or granted by APHIS were
those which contains the following information:
- Petition : the identification number of the petition. Technical descriptions of the transformation
events can be found in the individual petition documents which are obtainable from APHIS, for
example on the APHIS website, by reference to this petition number. These descriptions are
herein incorporated by reference.
- Extension of Petition : reference to a previous petition for which an extension is requested.
- Institution : the name of the entity submitting the petition.
- Regulated article : the plant species concerned.
- Transgenic phenotype : the trait conferred to the plants by the transformation event.
- Transformation event or line : the name of the event or events (sometimes also designated as
lines or lines) for which nonregulated status is requested.
- APHIS documents : various documents published by APHIS in relation to the Petition and
which can be requested with APHIS.
Additional particularly useful plants containing single transformation events or combinations of transformation
events are listed for example in the databases from various national or regional regulatory agencies (see for exam-
ple http://gmoinfo.jrc.it/gmp_browse.aspx and http://www.agbios.com/dbase.php).
Particularly useful transgenic plants which may be treated as described herein are plants containing transformation
events, or a combination of transformation events, and that are listed for example in the databases for various na-
tional or regional regulatory agencies including Event 1143-14A (cotton, insect control, not deposited, described
in ); Event 1143-51B (cotton, insect control, not deposited, described in );
Event 1445 (cotton, herbicide tolerance, not deposited, described in US-A 2002-120964 or WO 02/034946);
Event 17053 (rice, herbicide tolerance, deposited as PTA-9843, described in ); Event 17314
(rice, herbicide tolerance, deposited as PTA-9844, described in ); Event 281236 (cotton,
insect control - herbicide tolerance, deposited as PTA-6233, described in or US-A 2005-
216969); Event 300623 (cotton, insect control - herbicide tolerance, deposited as PTA-6233, described in
US-A 2007-143876 or ); Event 3272 (corn, quality trait, deposited as PTA-9972, described in
or US-A 2006-230473); Event 40416 (corn, insect control - herbicide tolerance, deposited as
ATCC PTA-11508, described in ); Event 43A47 (corn, insect control - herbicide tolerance, de-
posited as ATCC PTA-11509, described in ); Event 5307 (corn, insect control, deposited as
ATCC PTA-9561, described in ); Event ASR-368 (bent grass, herbicide tolerance, deposited as
ATCC PTA-4816, described in US-A 2006-162007 or ); Event B16 (corn, herbicide tolerance,
not deposited, described in US-A 2003-126634); Event BPS-CV127-9 (soybean, herbicide tolerance, deposited as
NCIMB No. 41603, described in ); Event CE43-67B (cotton, insect control, deposited as DSM
ACC2724, described in US-A 2009-217423 or WO2006/128573); Event CE44-69D (cotton, insect control, not
deposited, described in US-A 2010-0024077); Event CE44-69D (cotton, insect control, not deposited, described
in ); Event CE46-02A (cotton, insect control, not deposited, described in );
Event COT102 (cotton, insect control, not deposited, described in US-A 2006-130175 or );
Event COT202 (cotton, insect control, not deposited, described in US-A 2007-067868 or );
Event COT203 (cotton, insect control, not deposited, described in ); Event DAS40278 (corn,
herbicide tolerance, deposited as ATCC PTA-10244, described in ); Event DAS7 (corn,
insect control - herbicide tolerance, deposited as ATCC PTA 11384 , described in US-A 2006-070139); Event
DAS-59132 (corn, insect control - herbicide tolerance, not deposited, described in ); Event
DAS68416 (soybean, herbicide tolerance, deposited as ATCC PTA-10442, described in or
); Event DP6 (corn, herbicide tolerance, deposited as ATCC PTA-8296, described in
US-A 2009-137395 or ); Event DP1 (soybean, quality trait, not deposited, described in
US-A 2008-312082 or ); Event DP1 (corn, hybridization system, deposited as ATCC
PTA-9158, described in US-A 2009-0210970 or ); Event DP5 (soybean, herbicide to-
lerance, deposited as ATCC PTA-8287, described in US-A 2010-0184079 or ); Event EE-1
(brinjal, insect control, not deposited, described in ); Event FI117 (corn, herbicide tolerance,
deposited as ATCC 209031, described in US-A 2006-059581 or WO 98/044140); Event GA21 (corn, herbicide
tolerance, deposited as ATCC 209033, described in US-A 2005-086719 or WO 98/044140); Event GG25 (corn,
herbicide tolerance, deposited as ATCC 209032, described in US-A 2005-188434 or WO 98/044140); Event
GHB119 (cotton, insect control - herbicide tolerance, deposited as ATCC PTA-8398, described in WO
2008/151780); Event GHB614 (cotton, herbicide tolerance, deposited as ATCC PTA-6878, described in US-A
2010-050282 or ); Event GJ11 (corn, herbicide tolerance, deposited as ATCC 209030, de-
scribed in US-A 2005-188434 or WO 98/044140); Event GM RZ13 (sugar beet, virus resistance , deposited as
NCIMB-41601, described in ); Event H7-1 (sugar beet, herbicide tolerance, deposited as
NCIMB 41158 or NCIMB 41159, described in US-A 2004-172669 or ); Event JOPLIN1
(wheat, disease tolerance, not deposited, described in US-A 2008-064032); Event LL27 (soybean, herbicide toler-
ance, deposited as NCIMB41658, described in or US-A 2008-320616); Event LL55 (soybean,
herbicide tolerance, deposited as NCIMB 41660, described in or US-A 2008-196127); Event
LLcotton25 (cotton, herbicide tolerance, deposited as ATCC PTA-3343, described in WO 03/013224 or US-A
2003-097687); Event LLRICE06 (rice, herbicide tolerance, deposited as ATCC-23352, described in US
6,468,747 or WO 00/026345); Event LLRICE601 (rice, herbicide tolerance, deposited as ATCC PTA-2600, de-
scribed in US-A 2008-2289060 or WO 00/026356); Event LY038 (corn, quality trait, deposited as ATCC PTA-
5623, described in US-A 2007-028322 or ); Event MIR162 (corn, insect control, deposited as
PTA-8166, described in US-A 2009-300784 or ); Event MIR604 (corn, insect control, not de-
posited, described in US-A 2008-167456 or ); Event MON15985 (cotton, insect control, depo-
sited as ATCC PTA-2516, described in US-A 2004-250317 or WO 02/100163); Event MON810 (corn, insect
control, not deposited, described in US-A 2002-102582); Event MON863 (corn, insect control, deposited as
ATCC PTA-2605, described in or US-A 2006-095986); Event MON87427 (corn, pollination
control, deposited as ATCC PTA-7899, described in ); Event MON87460 (corn, stress toler-
ance, deposited as ATCC PTA-8910, described in or US-A 2011-0138504); Event MON87701
(soybean, insect control, deposited as ATCC PTA-8194, described in US-A 2009-130071 or );
Event MON87705 (soybean, quality trait - herbicide tolerance, deposited as ATCC PTA-9241, described in US-A
2010-0080887 or ); Event MON87708 (soybean, herbicide tolerance, deposited as ATCC
PTA9670, described in ); Event MON87754 (soybean, quality trait, deposited as ATCC PTA-
9385, described in ); Event MON87769 (soybean, quality trait, deposited as ATCC PTA-8911,
described in US-A 2011-0067141 or ); Event MON88017 (corn, insect control - herbicide to-
lerance, deposited as ATCC PTA-5582, described in US-A 2008-028482 or ); Event
MON88913 (cotton, herbicide tolerance, deposited as ATCC PTA-4854, described in or US-A
2006-059590); Event MON89034 (corn, insect control, deposited as ATCC PTA-7455, described in WO
2007/140256 or US-A 2008-260932); Event MON89788 (soybean, herbicide tolerance, deposited as ATCC
PTA-6708, described in US-A 2006-282915 or ); Event MS11 (oilseed rape, pollination control
- herbicide tolerance, deposited as ATCC PTA-850 or PTA-2485, described in WO 01/031042); Event MS8 (oil-
seed rape, pollination control - herbicide tolerance, deposited as ATCC PTA-730, described in WO 01/041558 or
US-A 2003-188347); Event NK603 (corn, herbicide tolerance, deposited as ATCC PTA-2478, described in US-A
2007-292854); Event PE-7 (rice, insect control, not deposited, described in ); Event RF3 (oil-
seed rape, pollination control - herbicide tolerance, deposited as ATCC PTA-730, described in WO 01/041558 or
US-A 2003-188347); Event RT73 (oilseed rape, herbicide tolerance, not deposited, described in WO 02/036831
or US-A 2008-070260); Event T227-1 (sugar beet, herbicide tolerance, not deposited, described in WO 02/44407
or US-A 2009-265817); Event T25 (corn, herbicide tolerance, not deposited, described in US-A 2001-029014 or
WO 01/051654); Event T304-40 (cotton, insect control - herbicide tolerance, deposited as ATCC PTA-8171, de-
scribed in US-A 2010-077501 or ); Event T342-142 (cotton, insect control, not deposited, de-
scribed in ); Event TC1507 (corn, insect control - herbicide tolerance, not deposited, described
in US-A 2005-039226 or ); Event VIP1034 (corn, insect control - herbicide tolerance, deposited
as ATCC PTA-3925., described in WO 03/052073), Event 32316 (corn,insect control-herbicide toler-
ance,deposited as PTA-11507, described in ), Event 4114 (corn,insect control-herbicide toler-
ance,deposited as PTA-11506, described in ).
In the context described herein, the active compound combinations as described or compositions according
to the invention are applied on their own or in a suitable formulation to the seed. Preferably, the seed is
treated in a state in which it is sufficiently stable so that the treatment does not cause any damage. In gener-
al, treatment of the seed may take place at any point in time between harvesting and sowing. Usually, the
seed used is separated from the plant and freed from cobs, shells, stalks, coats, hairs or the flesh of the fruits.
Thus, it is possible to use, for example, seed which has been harvested, cleaned and dried to a moisture con-
tent of less than 15 % by weight. Alternatively, it is also possible to use seed which, after drying, has been
treated, for example, with water and then dried again.
When treating the seed, care must generally be taken that the amount of the composition according to the in-
vention applied to the seed and/or the amount of further additives is chosen in such a way that the germination
of the seed is not adversely affected, or that the resulting plant is not damaged. This must be borne in mind in
particular in the case of active compounds which may have phytotoxic effects at certain application rates.
The compositions according to the invention can be applied directly, that is to say without comprising further
components and without having been diluted. In general, it is preferable to apply the compositions to the seed
in the form of a suitable formulation. Suitable formulations and methods for the treatment of seed are known to
the person skilled in the art and are described, for example, in the following documents: US 4,272,417 A, US
4,245,432 A, US 4,808,430 A, US 5,876,739 A, US 2003/0176428 A1, A1, WO
2002/028186 A2.
The active compound combinations which can be useful in the invention can be converted into customary
seed dressing formulations, such as solutions, emulsions, suspensions, powders, foams, slurries or other
coating materials for seed, and also ULV formulations.
These formulations are prepared in a known manner by mixing the active compounds or active compound
combinations with customary additives, such as, for example, customary extenders and also solvents or di-
luents, colorants, wetting agents, dispersants, emulsifiers, defoamers, preservatives, secondary thickeners,
adhesives, gibberellins and water as well.
Suitable colorants that may be present in the seed dressing formulations which can be useful in the inven-
tion include all colorants customary for such purposes. Use may be made both of pigments, of sparing solu-
bility in water, and of dyes, which are soluble in water. Examples that may be mentioned include the colo-
rants known under the designations Rhodamine B, C.I. Pigment Red 112, and C.I. Solvent Red 1.
Suitable wetting agents that may be present in the seed dressing formulations which can be useful in the in-
vention include all substances which promote wetting and are customary in the formulation of active agro-
chemical substances. With preference it is possible to use alkylnaphthalene-sulfonates, such as diisopropyl-
or diisobutylnaphthalene-sulfonates.
Suitable dispersants and/or emulsifiers that may be present in the seed dressing formulations which can be
useful in the invention include all nonionic, anionic, and cationic dispersants which are customary in the
formulation of active agrochemical substances. With preference, it is possible to use nonionic or anionic
dispersants or mixtures of nonionic or anionic dispersants. Particularly suitable nonionic dispersants are
ethylene oxide-propylene oxide block polymers, alkylphenol polyglycol ethers, and tristyrylphenol polygly-
col ethers, and their phosphated or sulfated derivatives. Particularly suitable anionic dispersants are ligno-
sulfonates, polyacrylic salts, and arylsulfonate-formaldehyde condensates.
Defoamers that may be present in the seed dressing formulations to be used as described herein include all
foam-inhibiting compounds which are customary in the formulation of agrochemically active compounds.
Preference is given to using silicone defoamers, magnesium stearate, silicone emulsions, long-chain alco-
hols, fatty acids and their salts and also organofluorine compounds and mixtures thereof.
Preservatives that may be present in the seed dressing formulations to be used as described herein include
all compounds which can be used for such purposes in agrochemical compositions. By way of example,
mention may be made of dichlorophen and benzyl alcohol hemiformal.
Secondary thickeners that may be present in the seed dressing formulations to be used as described herein in-
clude all compounds which can be used for such purposes in agrochemical compositions. Preference is given to
cellulose derivatives, acrylic acid derivatives, polysaccharides, such as xanthan gum or Veegum, modified
clays, phyllosilicates, such as attapulgite and bentonite, and also finely divided silicic acids.
Suitable adhesives that may be present in the seed dressing formulations to be used as described herein in-
clude all customary binders which can be used in seed dressings. Polyvinylpyrrolidone, polyvinyl acetate,
polyvinyl alcohol and tylose may be mentioned as being preferred.
Suitable gibberellins that may be present in the seed dressing formulations to be used as described herein
are preferably the gibberellins A1, A3 (= gibberellic acid), A4 and A7; particular preference is given to using
gibberellic acid. The gibberellins are known (cf. R. Wegler “Chemie der Pflanzenschutz- and Schäd-
lingsbekämpfungsmittel” [Chemistry of Crop Protection Agents and Pesticides], Vol. 2, Springer Verlag,
1970, pp. 401-412).
The seed dressing formulations which can be used as described herein may be used directly or after dilution
with water beforehand to treat seed of any of a very wide variety of types. The seed dressing formulations
which can be used as described herein or their dilute preparations may also be used to dress seed of trans-
genic plants. In this context, synergistic effects may also arise in interaction with the substances formed by
expression.
Suitable mixing equipment for treating seed with the seed dressing formulations which can be used as de-
scribed herein or the preparations prepared from them by adding water includes all mixing equipment which
can commonly be used for dressing. The specific procedure adopted when dressing comprises introducing
the seed into a mixer, adding the particular desired amount of seed dressing formulation, either as it is or
following dilution with water beforehand, and carrying out mixing until the formulation is uniformly distri-
buted on the seed. Optionally, a drying operation follows.
The active compounds as described or compositions according to the invention have strong microbicidal ac-
tivity and can be used for controlling unwanted microorganisms, such as fungi and bacteria, in crop protec-
tion and material protection.
In crop protection, fungicides can be used for controlling Plasmodiophoromycetes, Oomycetes, Chytridi-
omycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes.
In crop protection, bactericides can be used for controlling Pseudomonadaceae, Rhizobiaceae, Enterobacte-
riaceae, Corynebacteriaceae and Streptomycetaceae.
The fungicidal compositions according to the invention can be used for the curative or protective control of
phytopathogenic fungi. Accordingly, the invention also relates to curative and protective methods for control-
ling phytopathogenic fungi using the compositions according to the invention, which are applied to the seed,
the plant or plant parts, the fruit or the soil in which the plants grow. Curative and protective methods using the
active compound combinations described herein are also described. Preference is given to application onto the
plant or the plant parts, the fruits or the soil in which the plants grow.
The compositions according to the invention for combating phytopathogenic fungi in crop protection com-
prise an active, but non-phytotoxic amount of the compounds described herein. “Active, but non-phytotoxic
amount” shall mean an amount of the composition according to the invention which is sufficient to control
or to completely kill the plant disease caused by fungi, which amount at the same time does not exhibit
noteworthy symptoms of phytotoxicity. These application rates generally may be varied in a broader range,
which rate depends on several factors, e.g. the phytopathogenic fungi, the plant or crop, the climatic condi-
tions and the ingredients of the composition according to the invention.
The fact that the active compounds, at the concentrations required for the controlling of plant diseases, are well
tolerated by plants permits the treatment of aerial plant parts, of vegetative propagation material and seed, and
of the soil.
According to the invention, it is possible to treat all plants and parts of plants. Plants are to be understood here
as meaning all plants and plant populations, such as wanted and unwanted wild plants or crop plants (including
naturally occurring crop plants). Crop plants can be plants which can be obtained by conventional breeding and
optimization methods or by biotechnological and genetic engineering methods or combinations of these me-
thods, including the transgenic plants and including plant cultivars which can or cannot be protected by plant
variety protection rights. Parts of plants are to be understood as meaning all above-ground and below-ground
parts and organs of the plants, such as shoot, leaf, flower and root, examples which may be mentioned being
leaves, needles, stems, trunks, flowers, fruit bodies, fruits and seeds and also roots, tubers and rhizomes. Plant
parts also include harvested material and vegetative and generative propagation material, for example seedl-
ings, tubers, rhizomes, cuttings and seeds. Preference is given to the treatment of the plants and the above-
ground and below-ground parts and organs of the plants, such as shoot, leaf, flower and root, examples which
may be mentioned being leaves, needles, stems, trunks, flowers, and fruits.
The active compounds, in combination with good plant tolerance and favourable toxicity to warm-blooded
animals and being tolerated well by the environment, are suitable for protecting plants and plant organs, for
increasing the harvest yields, for improving the quality of the harvested material. They may be preferably
employed as crop protection agents. They are active against normally sensitive and resistant species and
against all or some stages of development.
The following plants may be mentioned as plants which can be treated: cotton, flax, grapevines, fruit, vege-
table, such as Rosaceae sp. (for example pomaceous fruit, such as apples and pears, but also stone fruit,
such as apricots, cherries, almonds and peaches and soft fruit such as strawberries), Ribesioidae sp., Juglan-
daceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp.,
Lauraceae sp., Musaceae sp. (for example banana trees and plantations), Rubiaceae sp. (for example cof-
fee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for example lemons, oranges and grapefruit), Solanaceae
sp. (for example tomatoes), Liliaceae sp., Asteraceae sp. (for example lettuce), Umbelliferae sp., Cruciferae
sp., Chenopodiaceae sp., Cucurbitaceae sp. (for example cucumbers), Alliaceae sp. (for example leek,
onions), Papilionaceae sp. (for example peas); major crop plants, such Gramineae sp. (for example maize,
lawn, cereals such as wheat, rye, rice, barley, oats, millet and triticale), Asteraceae sp. (for example sun-
flowers), Brassicaceae sp. (for example white cabbage, red cabbage, broccoli, cauliflowers, Brussels
sprouts, pak choi, kohlrabi, garden radish, and also oilseed rape, mustard, horseradish and cress), Fabacae
sp. (for example beans, peas, peanuts), Papilionaceae sp. (for example soya beans), Solanaceae sp. (for ex-
ample potatoes), Chenopodiaceae sp. (for example sugar beet, fodder beet, Swiss chard, beetroot); crop
plants and ornamental plants in garden and forest; and also in each case genetically modified varieties of
these plants.
As already mentioned above, it is possible to treat all plants and their parts according to the invention. In a
preferred embodiment, wild plant species and plant cultivars, or those obtained by conventional biological
breeding methods, such as crossing or protoplast fusion, and parts thereof, are treated. In a further preferred
embodiment, transgenic plants and plant cultivars obtained by genetic engineering methods, if appropriate
in combination with conventional methods (genetically modified organisms), and parts thereof are treated.
The terms "parts", "parts of plants" and "plant parts" have been explained above. Particularly preferably,
plants of the plant cultivars which are in each case commercially available or in use are treated as described
herein. Plant cultivars are to be understood as meaning plants having novel properties (“traits”) which have
been obtained by conventional breeding, by mutagenesis or by recombinant DNA techniques. These can be
cultivars, bio- or genotypes.
In material protection the substances described herein may be used for the protection of technical materials
against infestation and destruction by undesirable fungi and/or microorganisms.
Technical materials are understood to be in the present context non-living materials that have been prepared
for use in engineering. For example, technical materials that are to be protected against micro-biological
change or destruction by the active materials of the invention can be adhesives, glues, paper and cardboard,
textiles, carpets, leather, wood, paint and plastic articles, cooling lubricants and other materials that can be
infested or destroyed by micro-organisms. Within the context of materials to be protected are also parts of
production plants and buildings, for example cooling circuits, cooling and heating systems, air conditioning
and ventilation systems, which can be adversely affected by the propagation of fungi and/or microorga-
nisms. Within the context of the present disclosure, preferably mentioned as technical materials are adhe-
sives, glues, paper and cardboard, leather, wood, paints, cooling lubricants and heat exchanger liquids, par-
ticularly preferred is wood. The combinations described herein can prevent disadvantageous effects like de-
caying, dis- and decoloring, or molding. The active compound combinations described herein and composi-
tions according to the invention can likewise be employed for protecting against colonization of objects, in
particular ship hulls, sieves, nets, buildings, quays and signalling installations, which are in contact with sea
water or brackish water.
The method of treatment described herein can also be used in the field of protecting storage goods against at-
tack of fungi and microorganisms. As used herein, the term “storage goods” is understood to denote natural
substances of vegetable or animal origin and their processed forms, which have been taken from the natural
life cycle and for which long-term protection is desired. Storage goods of vegetable origin, such as plants or
parts thereof, for example stalks, leafs, tubers, seeds, fruits or grains, can be protected in the freshly har-
vested state or in processed form, such as pre-dried, moistened, comminuted, ground, pressed or roasted.
Also falling under the definition of storage goods is timber, whether in the form of crude timber, such as
construction timber, electricity pylons and barriers, or in the form of finished articles, such as furniture or
objects made from wood. Storage goods of animal origin are hides, leather, furs, hairs and the like. The
combinations described herein can prevent disadvantageous effects such as decay, discoloration or mold.
Preferably “storage goods” is understood to denote natural substances of vegetable origin and their
processed forms, more preferably fruits and their processed forms, such as pomes, stone fruits, soft fruits
and citrus fruits and their processed forms.
Some pathogens of fungal diseases which can be treated as described herein may be mentioned by way of
example, but not by way of limitation:
Diseases caused by powdery mildew pathogens, such as, for example, Blumeria species, such as, for exam-
ple, Blumeria graminis; Podosphaera species, such as, for example, Podosphaera leucotricha; Sphaerotheca
species, such as, for example, Sphaerotheca fuliginea; Uncinula species, such as, for example, Uncinula ne-
cator;
Diseases caused by rust disease pathogens, such as, for example, Gymnosporangium species, such as, for
example, Gymnosporangium sabinae; Hemileia species, such as, for example, Hemileia vastatrix; Phakop-
sora species, such as, for example, Phakopsora pachyrhizi and Phakopsora meibomiae; Puccinia species,
such as, for example, Puccinia recondita or Puccinia triticina; Uromyces species, such as, for example,
Uromyces appendiculatus;
Diseases caused by pathogens from the group of the Oomycetes, such as, for example, Bremia species, such
as, for example, Bremia lactucae; Peronospora species, such as, for example, Peronospora pisi or P. brassi-
cae; Phytophthora species, such as, for example Phytophthora infestans; Plasmopara species, such as, for
example, Plasmopara viticola; Pseudoperonospora species, such as, for example, Pseudoperonospora humuli
or Pseudoperonospora cubensis; Pythium species, such as, for example, Pythium ultimum;
Leaf blotch diseases and leaf wilt diseases caused, for example, by Alternaria species, such as, for example, Al-
ternaria solani; Cercospora species, such as, for example, Cercospora beticola; Cladiosporium species, such as,
for example, Cladiosporium cucumerinum; Cochliobolus species, such as, for example, Cochliobolus sativus
(conidia form: Drechslera, Syn: Helminthosporium); Colletotrichum species, such as, for example, Colletotri-
chum lindemuthanium; Cycloconium species, such as, for example, Cycloconium oleaginum; Diaporthe spe-
cies, such as, for example, Diaporthe citri; Elsinoe species, such as, for example, Elsinoe fawcettii; Gloeospo-
rium species, such as, for example, Gloeosporium laeticolor; Glomerella species, such as, for example, Glome-
rella cingulata; Guignardia species, such as, for example, Guignardia bidwelli; Leptosphaeria species, such as,
for example, Leptosphaeria maculans; Magnaporthe species, such as, for example, Magnaporthe grisea; Mi-
crodochium species, such as, for example, Microdochium nivale; Mycosphaerella species, such as, for exam-
ple, Mycosphaerella graminicola and M. fijiensis; Phaeosphaeria species, such as, for example, Phaeosphaeria
nodorum; Pyrenophora species, such as, for example, Pyrenophora teres; Ramularia species, such as, for ex-
ample, Ramularia collo-cygni; Rhynchosporium species, such as, for example, Rhynchosporium secalis; Septo-
ria species, such as, for example, Septoria apii; Typhula species, such as, for example, Typhula incarnata; Ven-
turia species, such as, for example, Venturia inaequalis;
Root and stem diseases caused, for example, by Corticium species, such as, for example, Corticium grami-
nearum; Fusarium species, such as, for example, Fusarium oxysporum; Gaeumannomyces species, such as,
for example, Gaeumannomyces graminis; Rhizoctonia species, such as, for example Rhizoctonia solani; Ta-
pesia species, such as, for example, Tapesia acuformis; Thielaviopsis species, such as, for example, Thiela-
viopsis basicola;
Ear and panicle diseases (including maize cobs) caused, for example, by Alternaria species, such as, for ex-
ample, Alternaria spp.; Aspergillus species, such as, for example, Aspergillus flavus; Cladosporium species,
such as, for example, Cladosporium cladosporioides; Claviceps species, such as, for example, Claviceps
purpurea; Fusarium species, such as, for example, Fusarium culmorum; Gibberella species, such as, for ex-
ample, Gibberella zeae; Monographella species, such as, for example, Monographella nivalis; Septoria spe-
cies, such as for example, Septoria nodorum;
Diseases caused by smut fungi, such as, for example, Sphacelotheca species, such as, for example, Sphacelo-
theca reiliana; Tilletia species, such as, for example, Tilletia caries; T. controversa; Urocystis species, such as,
for example, Urocystis occulta; Ustilago species, such as, for example, Ustilago nuda; U. nuda tritici;
Fruit rot caused, for example, by Aspergillus species, such as, for example, Aspergillus flavus; Botrytis spe-
cies, such as, for example, Botrytis cinerea; Penicillium species, such as, for example, Penicillium expan-
sum and P. purpurogenum; Sclerotinia species, such as, for example, Sclerotinia sclerotiorum; Verticilium
species, such as, for example, Verticilium alboatrum;
Seed- and soil-borne rot and wilt diseases, and also diseases of seedlings, caused, for example, by Fusarium
species, such as, for example, Fusarium culmorum; Phytophthora species, such as, for example, Phytophtho-
ra cactorum; Pythium species, such as, for example, Pythium ultimum; Rhizoctonia species, such as, for ex-
ample, Rhizoctonia solani; Sclerotium species, such as, for example, Sclerotium rolfsii;
Cancerous diseases, galls and witches’ broom caused, for example, by Nectria species, such as, for example,
Nectria galligena;
Wilt diseases caused, for example, by Monilinia species, such as, for example, Monilinia laxa;
Deformations of leaves, flowers and fruits caused, for example, by Taphrina species, such as, for example,
Taphrina deformans;
Degenerative diseases of woody plants caused, for example, by Esca species, such as, for example, Phae-
moniella clamydospora and Phaeoacremonium aleophilum and Fomitiporia mediterranea;
Diseases of flowers and seeds caused, for example, by Botrytis species, such as, for example, Botrytis cinerea;
Diseases of plant tubers caused, for example, by Rhizoctonia species, such as, for example, Rhizoctonia so-
lani; Helminthosporium species, such as, for example, Helminthosporium solani;
Diseases caused by bacteriopathogens, such as, for example, Xanthomonas species, such as, for example,
Xanthomonas campestris pv. oryzae; Pseudomonas species, such as, for example, Pseudomonas syringae
pv. lachrymans; Erwinia species, such as, for example, Erwinia amylovora.
Preference is given to controlling the following diseases of soya beans:
Fungal diseases on leaves, stems, pods and seeds caused, for example, by alternaria leaf spot (Alternaria
spec. atrans tenuissima), anthracnose (Colletotrichum gloeosporoides dematium var. truncatum), brown spot
(Septoria glycines), cercospora leaf spot and blight (Cercospora kikuchii), choanephora leaf blight (Choane-
phora infundibulifera trispora (Syn.)), dactuliophora leaf spot (Dactuliophora glycines), downy mildew (Pe-
ronospora manshurica), drechslera blight (Drechslera glycini), frogeye leaf spot (Cercospora sojina), leptos-
phaerulina leaf spot (Leptosphaerulina trifolii), phyllostica leaf spot (Phyllosticta sojaecola), pod and stem
blight (Phomopsis sojae), powdery mildew (Microsphaera diffusa), pyrenochaeta leaf spot (Pyrenochaeta
glycines), rhizoctonia aerial, foliage, and web blight (Rhizoctonia solani), rust (Phakopsora pachyrhizi Pha-
kopsora meibomiae), scab (Sphaceloma glycines), stemphylium leaf blight (Stemphylium botryosum), target
spot (Corynespora cassiicola).
Fungal diseases on roots and the stem base caused, for example, by black root rot (Calonectria crotala-
riae), charcoal rot (Macrophomina phaseolina), fusarium blight or wilt, root rot, and pod and collar rot
(Fusarium oxysporum, Fusarium orthoceras, Fusarium semitectum, Fusarium equiseti), mycoleptodiscus
root rot (Mycoleptodiscus terrestris), neocosmospora (Neocosmopspora vasinfecta), pod and stem blight
(Diaporthe phaseolorum), stem canker (Diaporthe phaseolorum var. caulivora), phytophthora rot (Phy-
tophthora megasperma), brown stem rot (Phialophora gregata), pythium rot (Pythium aphanidermatum,
Pythium irregulare, Pythium debaryanum, Pythium myriotylum, Pythium ultimum), rhizoctonia root rot,
stem decay, and damping-off (Rhizoctonia solani), sclerotinia stem decay (Sclerotinia sclerotiorum),
sclerotinia Southern blight (Sclerotinia rolfsii), thielaviopsis root rot (Thielaviopsis basicola).
It is also possible to control resistant strains of the organisms mentioned above.
Microorganisms capable of degrading or changing the industrial materials which may be mentioned are, for
example, bacteria, fungi, yeasts, algae and slime organisms. The active compounds preferably act against
fungi, in particular moulds, wood-discolouring and wood-destroying fungi (Basidiomycetes) and against
slime organisms and algae. Microorganisms of the following genera may be mentioned as examples: Alter-
naria, such as Alternaria tenuis, Aspergillus, such as Aspergillus niger, Chaetomium, such as Chaetomium
globosum, Coniophora, such as Coniophora puetana, Lentinus, such as Lentinus tigrinus, Penicillium, such
as Penicillium glaucum, Polyporus, such as Polyporus versicolor, Aureobasidium, such as Aureobasidium
pullulans, Sclerophoma, such as Sclerophoma pityophila, Trichoderma, such as Trichoderma viride, Esche-
richia, such as Escherichia coli, Pseudomonas, such as Pseudomonas aeruginosa, and Staphylococcus, such
as Staphylococcus aureus.
In addition, the compounds of the formula (I) as described herein also have very good antimycotic activity.
They have a very broad antimycotic activity spectrum in particular against dermatophytes and yeasts,
moulds and diphasic fungi (for example against Candida species such as Candida albicans, Candida glabra-
ta) and Epidermophyton floccosum, Aspergillus species such as Aspergillus niger and Aspergillus fumiga-
tus, Trichophyton species such as Trichophyton mentagrophytes, Microsporon species such as Microsporon
canis and audouinii. The list of these fungi by no means limits the mycotic spectrum which can be covered,
but is only for illustration.
When applying the compounds described herein the application rates can be varied within a broad range.
The dose of active compound/application rate usually applied in the method of treatment described herein is
generally and advantageously
• for treatment of part of plants, e.g. leafs (foliar treatment): from 0.1 to 10,000 g/ha, preferably from
to 1,000 g/ha, more preferably from 50 to 300 g/ha; in case of drench or drip application, the
dose can even be reduced, especially while using inert substrates like rockwool or perlite;
• for seed treatment: from 2 to 200 g per 100 kg of seed, preferably from 3 to 150 g per 100 kg of
seed, more preferably from 2.5 to 25 g per 100 kg of seed, even more preferably from 2.5 to 12.5 g
per 100 kg of seed;
• for soil treatment: from 0.1 to 10,000 g/ha, preferably from 1 to 5,000 g/ha.
The doses herein indicated are given as illustrative examples of the method according to the invention. A
person skilled in the art will know how to adapt the application doses, notably according to the nature of the
plant or crop to be treated.
The combination as described can be used in order to protect plants within a certain time range after the
treatment against pests and/or phytopathogenic fungi and/or microorganisms. The time range, in which pro-
tection is effected, spans in general 1 to 28 days, preferably 1 to 14 days, more preferably 1 to 10 days, even
more preferably 1 to 7 days after the treatment of the plants with the combinations or up to 200 days after
the treatment of plant propagation material.
Furthermore combinations as described and compositions according to the invention may also be used to
reduce the contents of mycotoxins in plants and the harvested plant material and therefore in foods and ani-
mal feed stuff made therefrom. Especially but not exclusively the following mycotoxins can be specified:
Deoxynivalenole (DON), Nivalenole, 15-Ac-DON, 3-Ac-DON, T2- und HT2- Toxins, Fumonisines, Zeara-
lenone Moniliformine, Fusarine, Diaceotoxyscirpenole (DAS), Beauvericine, Enniatine, Fusaroproliferine,
Fusarenole, Ochratoxines, Patuline, Ergotalkaloides und Aflatoxines, which are caused for example by the
following fungal diseases: Fusarium spec., like Fusarium acuminatum, F. avenaceum, F. crookwellense, F.
culmorum, F. graminearum (Gibberella zeae), F. equiseti, F. fujikoroi, F. musarum, F. oxysporum, F. proli-
feratum, F. poae, F. pseudograminearum, F. sambucinum, F. scirpi, F. semitectum, F. solani, F. sporotri-
choides, F. langsethiae, F. subglutinans, F. tricinctum, F. verticillioides and others but also by Aspergillus
spec., Penicillium spec., Claviceps purpurea, Stachybotrys spec. and others.
Also described is a composition as herein-defined comprising at least one further active ingredient selected
from the group of the insecticides, attractants, sterilants, bactericides, acaricides, nematicides, fungicides,
growth regulators, herbicides, fertilizers, safeners and semiochemicals.
Also described is a method for controlling phytopathogenic harmful fungi, characterized in that an active
compound combination as herein-defined is applied to the phytopathogenic harmful fungi and/or their habitat.
Also described is a process for producing compositions for controlling phytopathogenic harmful fungi, charac-
terized in that an active compound combination as herein-defined is mixed with extenders and/or surfactants.
Also described is the use of an active compound combination as herein-defined for control of phytopathogen-
ic harmful fungi.
Also described is the use of an active compound combination as herein-defined for the treatment of transgen-
ic plants.
Also described is the use of an active compound combination as herein-defined for the treatment of seed and
of seed of transgenic plants.
The advanced fungicidal activity of the active compound combinations described herein is evident from the
example below. While the individual active compounds exhibit weaknesses with regard to the fungicidal ac-
tivity, the combinations have an activity which exceeds a simple addition of activities.
A synergistic effect of fungicides is always present when the fungicidal activity of the active compound
combinations exceeds the total of the activities of the active compounds when applied individually. The ex-
pected activity for a given combination of two active compounds can be calculated as follows (cf. Colby,
S.R., "Calculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds 1967, 15,
-22):
X is the efficacy when active compound A is applied at an application rate of x ppm (or g/ha),
Y is the efficacy when active compound B is applied at an application rate of y ppm (or g/ha),
E is the efficacy when the active compounds A and B are applied at application rates of x and y ppm
(or g/ha), respectively, and
then
X ⋅Y
E = X + Y −
The degree of efficacy, expressed in % is denoted. 0% means an efficacy which corresponds to that of the
control while an efficacy of 100% means that no disease is observed.
If the actual fungicidal activity exceeds the calculated value, then the activity of the combination is superad-
ditive, i.e. a synergistic effect exists. In this case, the efficacy which was actually observed must be greater
than the value for the expected efficacy (E) calculated from the abovementioned formula.
A further way of demonstrating a synergistic effect is the method of Tammes (cf. “Isoboles, a graphic repre-
sentation of synergism in pesticides” in Neth. J. Plant Path., 1964, 70, 73-80).
The invention is illustrated by the following examples. However the invention is not limited to the example.
Example 1 : Phytophthora test (tomatoes) / preventive
Solvent: 24.5 parts by weight of acetone
24.5 parts by weight of N,N-dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with
the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concen-
tration.
To test for preventive activity, young plants are sprayed with the preparation of active compound at the
stated rate of application. After the spray coating has dried on, the plants are inoculated with an aqueous
spore suspension of Phytophthora infestans. The plants are then placed in an incubation cabinet at approx-
imately 20 °C and a relative atmospheric humidity of 100%.
The test is evaluated 3 days after the inoculation. 0% means an efficacy which corresponds to that of the un-
treated control, while an efficacy of 100% means that no disease is observed.
The table below clearly shows that the observed activity of the active compound combination described
herein is greater than the calculated activity, i.e. a synergistic effect is present.
Table 1a: Phytophthora test (tomatoes) / protective
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 100 0
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
c a r b o x a m i d e
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 100 25
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 100 30
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 100 32
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B3.1 ametoctradin 5 48
B4.6 fluopicolide 1 13
B9.4 iprovalicarb 5 48
B12.9 metalaxyl 5 18
A1 + B3.1 20:1 100 + 5 79 48
A17 + B3.1 20:1 100 + 5 81 64
A15 + B3.1 20:1 100 + 5 81 61
A18 + B3.1 20:1 100 + 5 83 65
A17 + B4.6 100:1 100 + 1 58 39
A15 + B4.6 100:1 100 + 1 55 35
A1 + B9.4 20:1 100 + 5 63 48
A17 + B12.9 20:1 100 + 5 54 43
A15 + B12.9 20:1 100 + 5 64 39
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 1b: Phytophthora test (tomatoes) / protective
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 0.25 0
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
c a r b o x a m i d e
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 0.5 0
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
0.25 0
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 0.5 0
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
0.25 0
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 0.25 0
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B3.3 azoxystrobin 1 50
B3.12 fluoxastrobin 2 49
B3.17 pyraclostrobin 1 53
A15 + B3.3 1:4 0.25 + 1 71 50
A18 + B3.3 1:4 0.25 + 1 76 50
A17 + B3.12 1:4 0.5 + 2 60 49
A15 + B3.12 1:4 0.5 + 2 78 49
A1 + B3.17 1:4 0.25 + 1 67 53
A17 + B3.17 1:4 0.25 + 1 77 53
A15 + B3.17 1:4 0.25 + 1 84 53
A18 + B3.17 1:4 0.25 + 1 72 53
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 1c: Phytophthora test (tomatoes) / protective
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 0,5 0
(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide
B5.4 chlorothalonil 50 75
B5.23 mancozeb 50 45
B5.29 propineb 50 50
A5 + B5.4 1:100 0,5 + 50 88 75
A5 + B5.23 1:100 0,5 + 50 85 45
A5 + B5.29 1:100 0,5 + 50 98 50
* found = activity found
** calc. = activity calculated using Colby’s formula
Example 2: Venturia test (apples) / preventive
Solvent: 24.5 parts by weight of acetone
24.5 parts by weight of N,N-dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with
the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concen-
tration.
To test for preventive activity, young plants are sprayed with the preparation of active compound at the
stated rate of application. After the spray coating has dried on, the plants are inoculated with an aqueous
conidia suspension of the causal agent of apple scab (Venturia inaequalis) and then remain for 1 day in an
incubation cabinet at approximately 20 °C and a relative atmospheric humidity of 100%.
The plants are then placed in a greenhouse at approximately 21 °C and a relative atmospheric humidity of
approximately 90%.
The test is evaluated 10 days after the inoculation. 0% means an efficacy which corresponds to that of the
untreated control, while an efficacy of 100% means that no disease is observed.
The table below clearly shows that the observed activity of the active compound combination described
herein is greater than the calculated activity, i.e. a synergistic effect is present.
Table 2a: Venturia test (apples) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 0.5 57
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
0.125 0
c a r b o x a m i d e
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 0.5 0
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
0.125 0
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 0.125 0
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 0.125 0
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B5.4 chlorothalonil 12.5 35
B5.16 folpet 12.5 47
B15.24 fosetyl-Al 50 0
B10.10 propamocarb-HCl 50 0
A1 + B5.4 1:100 0.125 + 12.5 53 35
A17 + B5.4 1:100 0.125 + 12.5 58 35
A15 + B5.4 1:100 0.125 + 12.5 85 35
A18 + B5.4 1:100 0.125 + 12.5 59 35
A17 + B5.16 1:100 0.125 + 12.5 76 47
A15 + B5.16 1:100 0.125 + 12.5 85 47
A18 + B5.16 1:100 0.125 + 12.5 82 47
A1 + B15.24 1:100 0.5 + 50 96 57
A15 + B15.24 1:100 0.5 + 50 87 0
A1 + B10.10 1:100 0.5 + 50 97 57
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 2b: Venturia test (apples) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 0.25 31
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
0.125 15
c a r b o x a m i d e
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 0.25 0
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 0.25 8
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 0.25 0
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
0.125 0
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B3.12 fluoxastrobin 0.5 61
B3.17 pyraclostrobin 1 79
A1 + B3.12 1:4 0.125 + 0.5 96 67
A18 + B3.12 1:4 0.125 + 0.5 77 61
A1 + B3.17 1:4 0.25 + 1 99 86
A17 + B3.17 1:4 0.25 + 1 88 81
A15 + B3.17 1:4 0.25 + 1 89 79
A18 + B3.17 1:4 0.25 + 1 95 79
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 2c: Venturia test (apples) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 0.25 0
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
c a r b o x a m i d e
B1.30 metconazole 1 38
A1 + B1.30 1:4 0.25 + 1 49 38
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 2d: Venturia test (apples) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 0.5 0
(difluoromethyl)fluoromethyl-1H-pyrazole
0.25 0
carboxamide
0.125
B1.41 prothioconazole 0.125 78
B2.8 fluxapyroxad 0.25 19
B2.11 isopyrazam (syn + anti) 0.25 88
B2.21 penthiopyrad 0.5 0
B2.22 sedaxane 0.5 53
A5 + B1.41 1:1 0.125 + 0.125 94 78
A5 + B2.8 1:1 0.25 + 0.25 91 19
A5 + B2.11 1:1 0.25 + 0.25 99 88
A5 + B2.21 1:1 0.5 + 0.5 78 0
A5 + B2.22 1:1 0.5 + 0.5 73 53
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 2e: Venturia test (apples) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 2 57
(difluoromethyl)fluoromethyl-1H-pyrazole
0.5 15
carboxamide
B2.29 benzovindiflupyr 0.1 76
B5.16 folpet 10 45
A5 + B2.29 1:0.2 0.5 + 0.1 95 80
A5 + B5.16 1:5 2 + 10 99 76
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 2f: Venturia test (apples) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 0.5 29
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
c a r b o x a m i d e
B15.78 N'-(4-{[3-(4-chlorobenzyl)-1,2,4-thiadiazolyl]oxy}-2,5- 5 16
dimethylphenyl)-N-ethyl-N-methylimidoformamide
A1 + B15.78 1:10 0.5 + 5 80 40
* found = activity found
** calc. = activity calculated using Colby’s formula
Example 3: Alternaria test (tomatoes) / preventive
Solvent: 24.5 parts by weight of acetone
24.5 parts by weight of N,N-dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with
the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concen-
tration.
To test for preventive activity, young plants are sprayed with the preparation of active compound at the
stated rate of application. After the spray coating has dried on, the plants are inoculated with an aqueous
spore suspension of Alternaria solani. The plants are then placed in an incubation cabinet at approximately
°C and a relative atmospheric humidity of 100%.
The test is evaluated 3 days after the inoculation. 0% means an efficacy which corresponds to that of the un-
treated control while an efficacy of 100% means that no disease is observed.
The table below clearly shows that the observed activity of the active compound combination described
herein is greater than the calculated activity, i.e. a synergistic effect is present.
Table 3a: Alternaria test (tomatoes) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 0.5 38
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
c a r b o x a m i d e
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 0.5 30
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B5.4 chlorothalonil 50 35
B5.23 mancozeb 50 56
B5.29 propineb 50 33
B15.24 fosetyl-Al 50 40
B10.10 propamocarb-HCl 50 0
A18+ B5.4 1:100 0.5 + 50 65 55
A1 + B5.23 1:100 0.5 + 50 95 73
A18 + B5.23 1:100 0.5 + 50 83 69
A1 + B5.29 1:100 0.5 + 50 67 58
A18+ B5.29 1:100 0.5 + 50 65 53
A18 + B15.24 1:100 0.5 + 50 68 58
A1 + B10.10 1:100 0.5 + 50 58 38
A18 + B10.10 1:100 0.5 + 50 50 30
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 3b: Alternaria test (tomatoes) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 0.5 59
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
0.25 53
c a r b o x a m i d e
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 0.5 63
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
0.25
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 0.5 71
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 0.5 43
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
0. 25 30
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B1.16 fenhexamid 50 22
B6.2 isotianil 50 27
B7.7 pyrimethanil 25 26
A1 + B1.16 1:100 0.5 + 50 89 68
A17 + B1.16 1:100 0.5 + 50 93 77
A15 + B1.16 1:100 0.5 + 50 92 71
A18 + B1.16 1:100 0.5 + 50 83 56
A1 + B6.2 1:100 0.5 + 50 81 70
A17 + B6.2 1:100 0.5 + 50 92 79
A18 + B6.2 1:100 0.5 + 50 76 58
A1 + B7.7 1:100 0.25 + 25 85 65
A15 + B7.7 1:100 0.25 + 25 94 70
A18 + B7.7 1:100 0.25 + 25 82 48
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 3c: Alternaria test (tomatoes) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 0.5 16
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
c a r b o x a m i d e
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 0.5 32
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B1.40 propiconazole 2 0
B1.41 prothioconazole 2 0
A17 + B1.40 1:4 0.5 + 2 48 32
A1 + B1.41 1:4 0.5 + 2 48 16
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 3d: Alternaria test (tomatoes) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 0.5 0
(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide
B5.23 mancozeb 50 0
B5.29 propineb 50 0
B15.60 2,6-dimethyl-1H,5H-[1,4]dithiino[2,3-c:5,6-c']dipyrrole- 50 0
1,3,5,7(2H,6H)-tetrone
A5 + B5.23 1:100 0.5 + 50 60 0
A5 + B5.29 1:100 0.5 + 50 75 0
A5 + B15.60 1:100 0.5 + 50 65 0
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 3e: Alternaria test (tomatoes) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 0.5 6
(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide
B2.29 benzovindiflupyr 0.5 21
B5.16 folpet 12.5 39
A5 + B2.29 1:1 0.5 + 0.5 59 26
A5 + B5.16 1:25 0.5 + 12.5 97 43
* found = activity found
** calc. = activity calculated using Colby’s formula
Example 4: Sphaerotheca test (cucumbers) / preventive
Solvent: 24.5 parts by weight of acetone
24.5 parts by weight of N,N-dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with
the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concen-
tration.
To test for protect activity, young plants are sprayed with the preparation of active compound at the stated
rate of application. After the spray coating has dried on, the plants are inoculated with an aqueous spore
suspension of Sphaerotheca fuliginea. The plants are then placed in a greenhouse at approximately 23 °C
and a relative atmospheric humidity of approximately 70%.
The test is evaluated 7 days after the inoculation. 0% means an efficacy which corresponds to that of the un-
treated control, while an efficacy of 100% means that no disease is observed.
The table below clearly shows that the observed activity of the active compound combination described
herein is greater than the calculated activity, i.e. a synergistic effect is present.
Table 4a: Sphaerotheca test (cucumbers) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 0.5 69
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e 0.25 19
c a r b o x a m i d e
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 0.5 74
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B5.16 folpet 25 0
B5.23 mancozeb 25 0
B5.29 propineb 50 0
B15.24 fosetyl-Al 50 0
B10.10 propamocarb-HCl 50 0
A1 + B5.16 1:100 0.25 + 25 62 19
A1 + B5.23 1:100 0.25 + 25 62 19
A1 + B5.29 1:100 0.5 + 50 81 69
A17 + B5.29 1:100 0.5 + 50 86 74
A1 + B15.24 1:100 0.5 + 50 79 69
A17 + B15.24 1:100 0.5 + 50 93 74
A17 + B10.10 1:100 0.5 + 50 88 74
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 4b: Sphaerotheca test (cucumbers) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 0.25 48
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
c a r b o x a m i d e
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 0.25 71
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B1.46 spiroxamine 25 0
A1 + B1.46 1:100 0.25 + 25 62 48
A17 + B1.46 1:100 0.25 + 25 88 71
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 4c: Sphaerotheca test (cucumbers) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 0.25 21
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
0.125 0
c a r b o x a m i d e
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 0.25 29
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
0.125
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 0. 25 13
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B1.5 cyproconazole 0.5 30
B3.22 trifloxystrobin 1 21
A1 + B1.15 1:4 0.125 + 0.5 50 30
A15 + B1.15 1:4 0.125 + 0.5 50 30
A1 + B3.22 1:4 0.25 + 1 54 38
A15 + B3.22 1:4 0.25 + 1 73 44
A18 + B3.22 1:4 0.25 + 1 67 31
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 4d: Sphaerotheca test (cucumbers) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 0.5 0
(difluoromethyl)fluoromethyl-1H-pyrazole
0.125 0
carboxamide
B1.30 metconazole 5 77
B1.40 propiconazole 1.25 57
B1.47 tebuconazole 1.25 0
B2.1 bixafen 0.5 67
B2.8 fluxapyroxad 0.5 0
B2.20 penflufen 0.5 0
B2.21 penthiopyrad 0.5 0
B3.3 azoxystrobin 2 50
B3.17 pyraclostrobin 2 0
B5.29 propineb 50 70
B10.10 propamocarb-HCl 50 70
B15.24 fosetyl-Al 12.5 0
A5 + B1.30 1:10 0.5 + 5 100 77
A5 + B1.40 1:10 0.125 + 12.5 77 57
A5 + B1.47 1:10 0.125 + 1.25 90 0
A5 + B2.1 1:1 0.5 + 0.5 77 67
A5 + B2.8 1:1 0.5 + 0.5 77 0
A5 + B2.20 1:1 0.5 + 0.5 50 0
A5 + B2.21 1:1 0.5 + 0.5 50 0
A5 + B3.3 1:4 0.5 + 2 90 50
A5 + B3.17 1:4 0.5 + 2 100 0
A5 + B5.29 1:100 0.5 + 5 100 70
A5 + B10.10 1:100 0.5 + 50 90 70
A5 + B15.24 1:100 0.125 + 12.5 70 0
* found = activity found
** calc. = activity calculated using Colby’s formula
Example 5: Botrytis test (beans) / preventive
Solvent: 24.5 parts by weight of acetone
24.5 parts by weight of N,N-dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with
the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concen-
tration.
To test for preventive activity, young plants are sprayed with the preparation of active compound. After the
spray coating has dried on, 2 small pieces of agar covered with growth of Botrytis cinerea are placed on
each leaf. The inoculated plants are placed in a darkened chamber at 20 °C and a relative atmospheric hu-
midity of 100%.
2 days after the inoculation, the size of the lesions on the leaves is evaluated. 0% means an efficacy which
corresponds to that of the untreated control, while an efficacy of 100% means that no disease is observed.
The table below clearly shows that the observed activity of the active compound combination described
herein is greater than the calculated activity, i.e. a synergistic effect is present.
Table 5a: Botrytis test (beans) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 2.5 8
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B1.16 fenhexamid 2.5 51
B13.3 fludioxonil 2.5 53
A15 + B1.16 1:1 2.5 + 2.5 83 55
A15 + B13.3 1:1 2.5 + 2.5 80 57
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 5b: Botrytis test (beans) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 2 72
(difluoromethyl)fluoromethyl-1H-pyrazole
0.5 16
carboxamide
B1.16 fenhexamid 2 0
B7.7 pyrimethanil 10 24
B13.3 fludioxonil 0.5 0
A5 + B1.16 1:1 2 + 2 86 72
A5 + B7.7 1:20 0.5 + 10 60 36
A5 + B13.3 1:1 0.5 + 0.5 52 16
* found = activity found
** calc. = activity calculated using Colby’s formula
Example 6: Blumeria test (barley) / preventive
Solvent: 49 parts by weight of N,N-dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To produce a suitable preparation of active compound, 1 part by weight of active compound or active com-
pound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is di-
luted with water to the desired concentration.
To test for preventive activity, young plants are sprayed with the preparation of active compound or active
compound combination at the stated rate of application.
After the spray coating has been dried, the plants are dusted with spores of Blumeria graminis f.sp. hordei.
The plants are placed in the greenhouse at a temperature of approximately 18 °C and a relative atmospheric
humidity of approximately 80% to promote the development of mildew pustules.
The test is evaluated 7 days after the inoculation. 0% means an efficacy which corresponds to that of the
untreated control, while an efficacy of 100% means that no disease is observed.
Table 6a: Blumeria test (barley) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 10 95
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B3.3 azoxystrobin 10 0
B2.21 penthiopyrad 20 20
A17 + B3.3 1:1 10 + 10 100 95
A17 + B2.21 1:2 10 + 20 100 96
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 6b: Blumeria test (barley) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 40 70
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o 10 13
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B3.17 pyraclostrobin 40 20
B6.2 isotianil 100 38
A15 + B3.17 1:1 40 + 40 90 76
A15 + B6.2 1:10 10 + 100 75 46
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 6c: Blumeria test (barley) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
found* calc.**
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 40 75
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B5.23 mancozeb 400 0
B5.29 propineb 400 13
B10.10 propamocarb-HCl 400 13
A15 + B5.23 1:10 40 + 400 100 75
A15 + B5.29 1:10 40 + 400 100 78
A15 + B10.10 1:10 40 + 400 100 78
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 6d: Blumeria test (barley) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
found* calc.**
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 10 56
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B1.47 tebuconazole 10 33
B1.5 cyproconazole 20 78
B2.6 fluopyram 20 11
A18 + B1.47 1:1 10 + 10 89 71
A18 + B1.5 1:2 10 + 20 100 90
A18 + B2.6 1:2 10 + 20 100 61
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 6e: Blumeria test (barley) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 10 29
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B9.4 iprovalicarb 100 0
B13.3 fludioxonil 100 0
A18 + B9.4 1:10 10 + 100 71 29
A18 + B13.3 1:10 10 + 100 71 29
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 6f: Blumeria test (barley) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 40 25
(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide
A12 N-cyclopropyl(difluoromethyl)fluoro-N-(2-isopropyl- 10 50
-methylbenzyl)methyl-1H-pyrazolecarboxamide
B1.47 tebuconazole 10 50
B4.6 fluopicolide 400 13
B12.10 mefenoxam 400 25
B13.3 fludioxonil 400 13
A5 + B4.6 1:10 40 + 400 88 35
A5 + B12.10 1:10 40 + 400 100 44
A5 + B13.3 1:10 40 + 400 88 35
A12 + B1.47 1:1 10 + 10 88 75
* found = activity found
** calc. = activity calculated using Colby’s formula
Example 7: Fusarium graminearum-test (barley) / preventive
Solvent: 49 parts by weight of N,N-dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To produce a suitable preparation of active compound, 1 part by weight of active compound or active com-
pound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is di-
luted with water to the desired concentration.
To test for preventive activity, young plants are sprayed with the preparation of active compound or active
compound combination at the stated rate of application.
After the spray coating has been dried, the plants are slightly injured by using a sandblast and afterwards
they are sprayed with a conidia suspension of Fusarium graminearum.
The plants are placed in the greenhouse under a translucent incubation cabinet at a temperature of approx-
imately 22 °C and a relative atmospheric humidity of approximately 100%.
The test is evaluated 5 days after the inoculation. 0% means an efficacy which corresponds to that of the un-
treated control, while an efficacy of 100% means that no disease is observed.
Table 7a: Fusarium graminearum-test (barley) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 10 50
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B3.22 trifloxystrobin 10 0
A17 + B3.22 1:1 10 + 10 75 50
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 7b: Fusarium graminearum-test (barley) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 40 0
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
0
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B2.11 isopyrazam (syn + anti) 40 0
B3.22 trifloxystrobin 10 25
A15 + B2.11 1:1 40 + 40 75 0
A15 + B3.22 1:1 10 + 10 75 25
* found = activity found
** calc. = activity calculated using Colby’s formula
Example 8: Fusarium nivale (var. majus)-test (wheat) / preventive
Solvent: 49 parts by weight of N,N-dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To produce a suitable preparation of active compound, 1 part by weight of active compound or active com-
pound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is di-
luted with water to the desired concentration.
To test for preventive activity, young plants are sprayed with the preparation of active compound or active
compound combination at the stated rate of application.
After the spray coating has been dried, the plants are slightly injured by using a sandblast and afterwards
they are sprayed with a conidia suspension of Fusarium nivale (var. majus).
The plants are placed in the greenhouse under a translucent incubation cabinet at a temperature of approx-
imately 10 °C and a relative atmospheric humidity of approximately 100%.
The test is evaluated 5 days after the inoculation. 0% means an efficacy which corresponds to that of the un-
treated control, while an efficacy of 100% means that no disease is observed.
Table 8a: Fusarium nivale (var. majus)-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 40 29
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
0
c a r b o x a m i d e
B2.20 penflufen 20 14
B3.17 pyraclostrobin 40 93
A1 + B2.20 1:2 10 + 20 71 14
A1 + B3.17 1:1 40 + 40 100 95
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 8b: Fusarium nivale (var. majus)-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 10 43
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B1.40 propiconazole 20 0
B2.1 bixafen 10 14
B2.20 penflufen 20 29
A18 + B1.40 1:2 10 + 20 71 43
A18 + B2.1 1:1 10 + 10 86 51
A18 + B2.20 1:2 10 + 20 86 60
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 8c: Fusarium nivale (var. majus)-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 10 63
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B1.30 metconazole 20 13
B1.47 tebuconazole 10 25
B2.21 penthiopyrad 20 13
B3.12 fluoxastrobin 10 50
A15 + B1.30 1:2 10 + 20 75 68
A15 + B1.47 1:1 10 + 10 100 72
A15 + B2.21 1:2 10 + 20 88 68
A15 + B3.12 1:1 10 + 10 100 82
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 8d: Fusarium nivale (var. majus)-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 10 43
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B3.17 pyraclostrobin 10 71
A17 + B3.17 1:1 10 + 10 100 84
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 8e: Fusarium nivale (var. majus)-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 40 0
(difluoromethyl)fluoromethyl-1H-pyrazole
0
carboxamide
B1.12 epoxiconazole 40 0
B1.30 metconazole 80 0
B1.47 tebuconazole 40 0
B2.21 penthiopyrad 80 0
B2.22 sedaxane 80 0
B3.12 fluoxastrobin 10 43
B3.17 pyraclostrobin 10 57
B3.3 azoxystrobin 40 0
A5 + B1.12 1:1 40 + 40 71 0
A5 + B1.30 1:2 40 + 80 71 0
A5 + B1.47 1:1 40 + 40 71 0
A5 + B2.21 1:2 40 + 80 93 0
A5 + B2.22 1:2 40 + 80 57 0
A5 + B3.12 1:1 10 + 10 71 43
A5 + B3.17 1:1 10 + 10 71 57
A5 + B3.3 1:1 40 + 40 43 0
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 8f: Fusarium nivale (var. majus)-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 40 38
(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide
B2.29 benzovindiflupyr 120 25
B5.16 folpet 200 50
A5 + B2.29 1:3 40 + 120 63 54
A5 + B5.16 1:5 40 + 200 88 69
* found = activity found
** calc. = activity calculated using Colby’s formula
Example 9: Leptosphaeria nodorum test (wheat) / preventive
Solvent: 49 parts by weight of N,N-dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To produce a suitable preparation of active compound, 1 part by weight of active compound or active com-
pound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is di-
luted with water to the desired concentration.
To test for preventive activity, young plants are sprayed with the preparation of active compound or active
compound combination at the stated rate of application.
After the spray coating has been dried, the plants are sprayed with a spore suspension of Leptosphaeria no-
dorum. The plants remain for 48 hours in an incubation cabinet at approximately 20 °C and a relative at-
mospheric humidity of approximately 100%.
The plants are placed in the greenhouse at a temperature of approximately 22 °C and a relative atmospheric
humidity of approximately 80%.
The test is evaluated 8 days after the inoculation. 0% means an efficacy which corresponds to that of the un-
treated control, while an efficacy of 100% means that no disease is observed.
Table 9a: Leptosphaeria nodorum test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 40 71
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
29
c a r b o x a m i d e
B1.5 cyproconazole 80 29
B1.12 epoxiconazole 10 0
B1.46 spiroxamine 200 29
B2.1 bixafen 40 0
B2.22 sedaxane 80 0
B2.6 fluopyram 80 0
B3.12 fluoxastrobin 40 43
A1 + B1.5 1:2 40 + 80 93 79
A1 + B1.12 1:1 10 + 10 71 29
A1 + B1.46 1:5 40 + 200 86 79
A1 + B2.1 1:1 40 + 40 86 71
A1 + B2.22 1:2 40 + 80 93 71
A1 + B2.6 1:2 40 + 80 86 71
A1 + B3.12 1:1 40 + 40 93 83
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 9b: Leptosphaeria nodorum test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 10 0
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
c a r b o x a m i d e
B2.11 isopyrazam (syn + anti) 10 0
A1 + B2.11 1:1 10 + 10 71 0
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 9c: Leptosphaeria nodorum test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 10 50
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
c a r b o x a m i d e
B4.6 fluopicolide 100 17
B12.9 metalaxyl 100 33
A1 + B4.6 1:10 10 + 100 83 59
A1 + B12.9 1:10 10 + 100 83 67
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 9d: Leptosphaeria nodorum test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
found* calc.**
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 40 67
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
33
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B1.30 metconazole 80 44
B1.40 propiconazole 20 0
B1.46 spiroxamine 200 22
B1.47 tebuconazole 10 33
A17 + B1.30 1:2 40 + 80 89 82
A17 + B1.40 1:2 10 + 20 56 33
A17 + B1.46 1:5 40 + 200 89 74
A17 + B1.47 1:1 10 + 10 67 55
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 9e: Leptosphaeria nodorum test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 10 29
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B5.23 mancozeb 100 0
A17 + B5.23 1:10 10 + 100 71 29
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 9f: Leptosphaeria nodorum test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
found* calc.**
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 40 71
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
0
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B1.12 epoxiconazole 10 29
B3.17 pyraclostrobin 40 57
B3.22 trifloxystrobin 40 57
B12.10 mefenoxam 100 0
A18 + B1.12 1:1 10 + 10 71 29
A18 + B3.17 1:1 40 + 40 100 88
A18+ B3.22 1:1 40 + 40 93 88
A18 + B12.10 1:10 10 + 100 78 0
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 9g: Leptosphaeria nodorum test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 40 33
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B5.16 folpet 400 44
A18 + B5.16 1:10 40 + 400 89 62
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 9h: Leptosphaeria nodorum test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 40 60
(difluoromethyl)fluoromethyl-1H-pyrazole
20
carboxamide
B1.46 spiroxamine 200 40
B2.1 bixafen 40 0
B2.6 fluopyram 80 0
B2.8 fluxapyroxad 10 0
B2.20 penflufen 20 0
B3.12 fluoxastrobin 10 0
B3.22 trifloxystrobin 10 40
A5 + B1.46 1:5 40 + 200 90 76
A5 + B2.1 1:1 40 + 40 90 60
A5 + B2.6 1:2 40 + 80 90 60
A5 + B2.8 1:1 10 + 10 60 20
A5 + B2.20 1:2 10 + 20 60 20
A5 + B3.12 1:1 10 + 10 60 20
A5 + B3.22 1:1 10 + 10 80 52
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 9i: Leptosphaeria nodorum test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 40 67
(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide
B12.9 metalaxyl 400 0
A5 + B12.9 1:10 40 + 400 83 67
* found = activity found
** calc. = activity calculated using Colby’s formula
Example 10: Puccinia triticina-test (wheat) / preventive
Solvent: 49 parts by weight of N,N-dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To produce a suitable preparation of active compound, 1 part by weight of active compound or active com-
pound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is di-
luted with water to the desired concentration.
To test for preventive activity, young plants are sprayed with the preparation of active compound or active
compound combination at the stated rate of application.
After the spray coating has been dried, the plants are sprayed with a spore suspension of Puccinia triticina.
The plants remain for 48 hours in an incubation cabinet at approximately 20 °C and a relative atmospheric
humidity of approximately 100%.
The plants are placed in the greenhouse at a temperature of approximately 20 °C and a relative atmospheric
humidity of approximately 80%.
The test is evaluated 8 days after the inoculation. 0% means an efficacy which corresponds to that of the un-
treated control, while an efficacy of 100% means that no disease is observed.
Table 10a: Puccinia triticina-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 40 22
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
62.5 57
c a r b o x a m i d e
B1.47 tebuconazole 4 33
B2.21 penthiopyrad 80 78
B2.8 fluxapyroxad 40 67
B15.78 N'-(4-{[3-(4-chlorobenzyl)-1,2,4-thiadiazolyl]oxy}-2,5- 62.5 57
dimethylphenyl)-N-ethyl-N-methylimidoformamide
A1 + B1.47 1:1 40 + 40 100 48
A1 + B2.21 1:2 40 + 80 100 83
A1 + B2.8 1:1 40 + 40 100 74
A1 + B15.78 1:1 62.5 + 62.5 100 82
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 10b: Puccinia triticina-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 40 56
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
c a r b o x a m i d e
B12.10 mefenoxam 400 0
B13.3 fludioxonil 400 0
A1 + B12.10 1:10 40 + 400 89 56
A1 + B13.3 1:10 40 + 400 78 56
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 10c: Puccinia triticina-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
found* calc.**
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 40 67
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B7.7 pyrimethanil 400 11
B13.3 fludioxonil 400 0
A17 + B7.7 1:10 40 + 400 89 71
A17 + B13.3 1:10 40 + 400 89 67
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 10d: Puccinia triticina-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 40 78
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B2.1 bixafen 40 22
B2.8 fluxapyroxad 40 67
A17 + B2.1 1:1 40 + 40 94 83
A17 + B2.8 1:1 40 + 40 100 93
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 10e: Puccinia triticina-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 40 89
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
44
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B1.40 propiconazole 80 0
B1.46 spiroxamine 200 0
B2.8 fluxapyroxad 10 0
A15 + B1.40 1:2 40 + 80 100 89
A15 + B1.46 1:5 40 + 200 100 89
A15 + B2.8 1:1 10 + 10 78 44
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 10f: Puccinia triticina-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 40 78
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B12.9 metalaxyl 400 11
B12.10 mefenoxam 400 11
A15 + B12.9 1:10 40 + 400 100 80
A15+ B12.10 1:10 40 + 400 100 80
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 10g: Puccinia triticina-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 10 33
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B1.30 metconazole 20 44
B1.41 prothioconazole 20 11
B2.11 isopyrazam (syn + anti) 10 33
A18 + B1.30 1:2 10 + 20 78 62
A18+ B1.41 1:2 10 + 20 89 40
A18 + B2.11 1:1 10 + 10 67 55
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 10h: Puccinia triticina-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 40 94
(difluoromethyl)fluoromethyl-1H-pyrazole
44
carboxamide
A12 N-cyclopropyl(difluoromethyl)fluoro-N-(2-isopropyl- 40 89
-methylbenzyl)methyl-1H-pyrazolecarboxamide
B1.40 propiconazole 80 11
B1.41 prothioconazole 80 11
B1.5 cyproconazole 20 56
B2.1 bixafen 40 22
B2.11 isopyrazam (syn + anti) 10 33
A5 + B1.40 1:2 40 + 80 100 95
A5 + B1.41 1:2 40 + 80 100 95
A12 + B 1.41 1:2 40 + 80 100 90
A5 + B1.5 1:2 10 + 20 100 75
A12 + B2.1 1:1 40 + 40 100 91
A5 + B2.11 1:1 10 + 10 94 62
* found = activity found
** calc. = activity calculated using Colby’s formula
Example 11: Pyrenophora teres-test (barley) / preventive
Solvent: 49 parts by weight of N,N-dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To produce a suitable preparation of active compound, 1 part by weight of active compound or active com-
pound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is di-
luted with water to the desired concentration.
To test for preventive activity, young plants are sprayed with the preparation of active compound or active
compound combination at the stated rate of application.
After the spray coating has been dried, the plants are sprayed with a spore suspension of Pyrenophora teres.
The plants remain for 48 hours in an incubation cabinet at approximately 20 °C and a relative atmospheric
humidity of approximately 100%.
The plants are placed in the greenhouse at a temperature of approximately 20 °C and a relative atmospheric
humidity of approximately 80%.
The test is evaluated 8 days after the inoculation. 0% means an efficacy which corresponds to that of the un-
treated control, while an efficacy of 100% means that no disease is observed.
untreated control, while an efficacy of 100% means that no disease is observed.
Table 11a: Pyrenophora teres-test (barley) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 10 86
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B1.5 cyproconazole 20 0
B1.41 prothioconazole 20 14
B2.11 isopyrazam (syn + anti) 10 0
B2.20 penflufen 20 29
B2.22 sedaxane 20 0
B2.6 fluopyram 20 57
A17 + B1.5 1:2 10 + 20 93 86
A17 + B1.41 1:2 10 + 20 93 88
A17 + B2.11 1:1 10 + 10 93 86
A17 + B2.20 1:2 10 + 20 100 90
A17 + B2.22 1:2 10 + 20 100 86
A17 + B2.6 1:2 10 + 20 100 94
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 11b: Pyrenophora teres-test (barley) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A17 N - [ 2 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 10 89
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B9.4 iprovalicarb 100 33
A17 + B9.4 1:10 10 + 100 100 93
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 11c: Pyrenophora teres-test (barley) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 10 67
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B1.41 prothioconazole 20 22
A15 + B1.41 1:2 10 + 20 89 74
* found = activity found
** calc. = activity calculated using Colby’s formula
Example 12: Septoria tritici-test (wheat) / preventive
Solvent: 49 parts by weight of N,N-dimethylacetamide
Emulsifier: 1 part by weight of alkylaryl polyglycol ether
To produce a suitable preparation of active compound, 1 part by weight of active compound or active com-
pound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is di-
luted with water to the desired concentration.
To test for preventive activity, young plants are sprayed with the preparation of active compound or active
compound combination at the stated rate of application.
After the spray coating has been dried, the plants are sprayed with a spore suspension of Septoria tritici.
The plants remain for 48 hours in an incubation cabinet at approximately 20 °C and a relative atmospheric
humidity of approximately 100% and afterwards for 60 hours at approximately 15 °C in a translucent incu-
bation cabinet at a relative atmospheric humidity of approximately 100%.
The plants are placed in the greenhouse at a temperature of approximately 15 °C and a relative atmospheric
humidity of approximately 80%.
The test is evaluated 21 days after the inoculation. 0% means an efficacy which corresponds to that of the
untreated control, while an efficacy of 100% means that no disease is observed.
Table 12a: Septoria tritici-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A15 N - [ 5 - c h l o r o ( t r i f l u o r o m e t h y l ) b e n z y l ] - N - 10 57
c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o
m e t h y l - 1 H - p y r a z o l e c a r b o x a m i d e
B1.12 epoxiconazole 10 0
B1.5 cyproconazole 20 29
B2.1 bixafen 10 29
B2.20 penflufen 20 29
B2.22 sedaxane 20 14
B2.6 fluopyram 20 57
B3.3 azoxystrobin 10 29
A15 + B1.12 1:1 10 + 10 100 57
A15 + B1.5 1:2 10 + 20 86 69
A15 + B2.1 1:1 10 + 10 100 69
A15 + B2.20 1:2 10 + 20 100 69
A15 + B2.22 1:2 10 + 20 100 63
A15 + B2.6 1:2 10 + 20 100 82
A15 + B3.3 1:1 10 + 10 100 69
Table 12b: Septoria tritici-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A1 N - c y c l o p r o p y l ( d i f l u o r o m e t h y l ) f l u o r o - N - ( 2 - 10 50
i s o p r o p y l b e n z y l ) m e t h y l - 1 H - p y r a z o l e
c a r b o x a m i d e
B3.22 trifloxystrobin 10 13
A1 + B3.22 1:1 10 + 10 88 57
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 12c: Septoria tritici-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 10 89
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B2.8 fluxapyroxad 10 0
A18 + B2.8 1:1 10 + 10 100 89
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 12d: Septoria tritici-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A18 N - [ 3 - c h l o r o f l u o r o ( t r i f l u o r o m e t h y l ) - 10 80
b e n z y l ] - N - c y c l o p r o p y l ( d i f l u o r o m e t h y l )
f l u o r o m e t h y l - 1 H p y r a z o l e c a r b o x a m i d e
B12.9 metalaxyl 100 10
A18 + B12.9 1:10 10 + 100 100 82
* found = activity found
** calc. = activity calculated using Colby’s formula
Table 12e: Septoria tritici-test (wheat) / preventive
Active compounds Application rate of ac- Efficacy in %
tive compound in ppm
a.i.
found* calc.**
A5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl 40 93
(difluoromethyl)fluoromethyl-1H-pyrazole
carboxamide
A7 N-cyclopropyl(difluoromethyl)fluoro-N-(5-fluoro 10 71
isopropylbenzyl)methyl-1H-pyrazolecarboxamide
B1.41 prothioconazole 80 43
B1.47 tebuconazole 40 71
B2.1 bixafen 40 29
14
B3.12 fluoxastrobin
A7 + B1.41 1:2 40 + 80 100 96
A7 + B1.47 1:1 40 + 40 100 98
A7 + B2.1 1:1 40 + 40 100 95
A5 + B3.12 1:1 10 + 10 93 75
The term ‘comprising’ as used in this specification and claims means ‘consisting at least in part of’. When
interpreting statements in this specification and claims which includes the ‘comprising’, other features
besides the features prefaced by this term in each statement can also be present. Related terms such as
‘comprise’ and ‘comprised’ are to be interpreted in similar manner.
In this specification where reference has been made to patent specifications, other external documents, or
other sources of information, this is generally for the purpose of providing a context for discussing the
features of the invention. Unless specifically stated otherwise, reference to such external documents is not
to be construed as an admission that such documents, or such sources of information, in any jurisdiction, are
prior art, or form part of the common general knowledge in the art.
Claims (14)
1. An active composition comprising (A) at least one derivative of formula (I) 5 (I) wherein T represents an oxygen atom and X is selected from the group consisting of 2-isopropyl, 2-cyclopropyl, 2-tert-butyl, 5-chloroethyl, 5-chloroisopropyl, 2-ethylfluoro, 5-fluoro isopropyl, 2-cyclopropylfluoro, 2-fluoroisopropyl, 2-ethylmethyl, 2-isopropylmethyl, 2- cyclopropylmethyl, 2-tert-butylmethyl, 5-chloro(trifluoromethyl), 5-methyl 10 (trifluoromethyl), 2-chloro(trifluoromethyl), 3-chlorofluoro(trifluoromethyl) and 2-ethyl-4,5- dimethyl, or an agrochemically acceptable salt thereof, (B) at least one further active fungicidal compound B, selected from the group consisting of: cyproconazole (1130964), epoxiconazole (1063250), fenhexamid (1268338), metco- 15 nazole (1251166), propiconazole (602071), prothioconazole (1789286), spiroxamine (1181348), tebuconazole (1075343), bixafen (58180903), fluopyram (6580664), isopyrazam (mixture of syn-epimeric racemate 1RS,4SR,9RS and anti-epimeric racemate 1RS,4SR,9SR) (881651), isopyrazam (syn epimeric racemate 1RS,4SR,9RS), isopyrazam (syn-epimeric enantiomer 1R,4S,9R), isopyrazam (syn-epimeric enantiomer 1S,4R,9S), isopyra- 20 zam (anti-epimeric racemate 1RS,4SR,9SR), isopyrazam (anti-epimeric enantiomer 1R,4S,9S), isopyrazam (anti-epimeric enantiomer 1S,4R,9R), penflufen (4947938), penthiopyrad (1836753), sedaxane (8749676), fluxapyroxad (9072043), benzovindiflupyr, N-[1-(2,4- dichlorophenyl)methoxypropanyl](difluoromethyl)methyl-1H-pyrazolecarboxamide, ametoctradin (8653184), azoxystrobin (1318608), fluoxastrobin (3613779), pyraclo- 25 strobin (1750130), trifloxystrobin (1415177), fluopicolide (2391107), chlorothalonil (18976), folpet (1333), mancozeb (80187), propineb (120719), isotianil (224049- 04-1), pyrimethanil (531120), iprovalicarb (1409237), propamocarb (256061), meta- laxyl (578371), metalaxyl-M (mefenoxam) (706300), fludioxonil (1313411),fosetyl-Al (391488), 2,6-dimethyl-1H,5H-[1,4]dithiino[2,3-c:5,6-c']dipyrrole-1,3,5,7(2H,6H)-tetrone, N'-(4- 30 {[3-(4-chlorobenzyl)-1,2,4-thiadiazolyl]oxy}-2,5-dimethylphenyl)-N-ethyl-N- methylimidoformamide and salts thereof.
2. An active composition according to claim 1 wherein the compound (A) of formula (I) is selected from the group consisting of: N-cyclopropyl(difluoromethyl)fluoro-N-(2-isopropylbenzyl)methyl-1H-pyrazole carboxamide (compound A1), 5 N-(5-chloroisopropylbenzyl)-N-cyclopropyl(difluoromethyl)fluoromethyl-1H-pyrazole carboxamide (compound A5), N-cyclopropyl(difluoromethyl)fluoro-N-(5-fluoroisopropylbenzyl)methyl-1H-pyrazole carboxamide (compound A7), N-cyclopropyl(difluoromethyl)fluoro-N-(2-isopropylmethylbenzyl)methyl-1H-pyrazole 10 carboxamide (compound A12), N-[5-chloro(trifluoromethyl)benzyl]-N-cyclopropyl(difluoromethyl)fluoromethyl-1H- pyrazolecarboxamide (compound A15), N-[2-chloro(trifluoromethyl)benzyl]-N-cyclopropyl(difluoromethyl)fluoromethyl-1H- pyrazolecarboxamide (compound A17), and 15 N-[3-chlorofluoro(trifluoromethyl)benzyl]-N-cyclopropyl(difluoromethyl)fluoromethyl- 1H-pyrazolecarboxamide (compound A18).
3. Composition according to claim 1 or claim 2, comprising at least one further active ingredient se- lected from the group consisting of insecticides, attractants, sterilants, bactericides, acaricides, ne- 20 maticides, fungicides, growth regulators, herbicides, fertilizers, safeners and semiochemicals.
4. A composition for controlling phytopathogenic harmful fungi, comprising at least one active com- position according to any one of claims 1 to 3, and at least one extender and/or surfactant.
5. Process for producing compositions for controlling phytopathogenic harmful fungi, wherein an ac- tive composition according to any one of claims 1 to 4 is mixed with at least one extender and/or 25 surfactant.
6. A composition produced by the process according to claim 5.
7. Method for controlling phytopathogenic harmful fungi, wherein an active composition according to any one of claims 1 to 4 or 6 is applied to the phytopathogenic harmful fungi and/or their habitat.
8. Use of an active composition according to any one of claims 1 to 4 or 6 for control of phytopa- 30 thogenic harmful fungi.
9. Use of an active composition according to any one of claims 1 to 4 or 6 for the treatment of transgenic plants.
10. Use of an active composition according to any one of claims 1 to 4 or 6 for the treatment of seed and of seed of transgenic plants.
11. A composition as claimed in any one of claims 1 to 4 or 6, substantially as herein described with reference to any example thereof. 5
12. A process as claimed in claim 5, substantially as herein described with reference to any ex- ample thereof.
13. A method as claimed in claim 7, substantially as herein described with reference to any exam- ple thereof.
14. A use as claimed in any one of claims 8 to 10, substantially as herein described with reference 10 to any example thereof.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11356005.6 | 2011-04-22 | ||
EP11356005 | 2011-04-22 | ||
US201161486479P | 2011-05-16 | 2011-05-16 | |
US61/486,479 | 2011-05-16 | ||
PCT/EP2012/001676 WO2012143127A1 (en) | 2011-04-22 | 2012-04-18 | Active compound combinations comprising a (thio)carboxamide derivative and a fungicidal compound |
Publications (2)
Publication Number | Publication Date |
---|---|
NZ617827A NZ617827A (en) | 2015-05-29 |
NZ617827B2 true NZ617827B2 (en) | 2015-09-01 |
Family
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