NZ617576B2 - Use of 25-hydroxy vitamin d3 to promote phosphorous utilisation in ruminants - Google Patents
Use of 25-hydroxy vitamin d3 to promote phosphorous utilisation in ruminants Download PDFInfo
- Publication number
- NZ617576B2 NZ617576B2 NZ617576A NZ61757612A NZ617576B2 NZ 617576 B2 NZ617576 B2 NZ 617576B2 NZ 617576 A NZ617576 A NZ 617576A NZ 61757612 A NZ61757612 A NZ 61757612A NZ 617576 B2 NZ617576 B2 NZ 617576B2
- Authority
- NZ
- New Zealand
- Prior art keywords
- vitamin
- feed
- hydroxy
- animal
- ruminants
- Prior art date
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- JWUBBDSIWDLEOM-DCHLRESJSA-N 25-Hydroxyvitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C/C=C1\C[C@@H](O)CCC1=C JWUBBDSIWDLEOM-DCHLRESJSA-N 0.000 title claims abstract description 42
- 241000282849 Ruminantia Species 0.000 title claims abstract description 24
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title claims abstract description 18
- 230000001737 promoting Effects 0.000 claims abstract description 10
- 241000283690 Bos taurus Species 0.000 claims description 10
- 241000282832 Camelidae Species 0.000 claims description 3
- 241000283707 Capra Species 0.000 claims description 3
- 241000283898 Ovis Species 0.000 claims description 3
- 230000037396 body weight Effects 0.000 claims description 3
- 239000006052 feed supplement Substances 0.000 claims 1
- 235000005911 diet Nutrition 0.000 abstract description 14
- 230000037213 diet Effects 0.000 abstract description 14
- 210000003608 Feces Anatomy 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 6
- 230000036826 Excretion Effects 0.000 abstract description 5
- 210000002700 Urine Anatomy 0.000 abstract description 5
- 230000029142 excretion Effects 0.000 abstract description 5
- 239000010871 livestock manure Substances 0.000 abstract description 4
- 230000008979 phosphorus utilization Effects 0.000 abstract description 4
- 210000004080 Milk Anatomy 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 235000013336 milk Nutrition 0.000 abstract description 3
- 239000008267 milk Substances 0.000 abstract description 3
- 230000000153 supplemental Effects 0.000 abstract description 2
- 239000003674 animal food additive Substances 0.000 abstract 2
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 6
- 239000011574 phosphorus Substances 0.000 description 6
- 229910052698 phosphorus Inorganic materials 0.000 description 6
- 230000001502 supplementation Effects 0.000 description 6
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 5
- 229960004729 colecalciferol Drugs 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000011782 vitamin Substances 0.000 description 5
- 235000005282 vitamin D3 Nutrition 0.000 description 5
- 239000011647 vitamin D3 Substances 0.000 description 5
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 5
- 229940021056 vitamin D3 Drugs 0.000 description 5
- 235000013343 vitamin Nutrition 0.000 description 4
- 229930003231 vitamins Natural products 0.000 description 4
- 229940088594 Vitamin Drugs 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- 210000002381 Plasma Anatomy 0.000 description 2
- 241000282898 Sus scrofa Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 235000013325 dietary fiber Nutrition 0.000 description 2
- 235000002949 phytic acid Nutrition 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 210000001519 tissues Anatomy 0.000 description 2
- GMRQFYUYWCNGIN-ZVUFCXRFSA-N 1,25-dihydroxy vitamin D3 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-ZVUFCXRFSA-N 0.000 description 1
- 229960002535 Alfacalcidol Drugs 0.000 description 1
- OFHCOWSQAMBJIW-AVJTYSNKSA-N Alfacalcidol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 description 1
- 230000036912 Bioavailability Effects 0.000 description 1
- 210000004369 Blood Anatomy 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Diphosphoinositol tetrakisphosphate Chemical compound OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 229950002499 Fytic acid Drugs 0.000 description 1
- 210000001035 Gastrointestinal Tract Anatomy 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical class OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- 230000036740 Metabolism Effects 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229940068041 Phytic Acid Drugs 0.000 description 1
- 210000004767 Rumen Anatomy 0.000 description 1
- 229940029983 VITAMINS Drugs 0.000 description 1
- 229940021016 Vitamin IV solution additives Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003078 antioxidant Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000035514 bioavailability Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000037180 bone health Effects 0.000 description 1
- 230000037118 bone strength Effects 0.000 description 1
- 235000020964 calcitriol Nutrition 0.000 description 1
- 239000011612 calcitriol Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000020940 control diet Nutrition 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 235000021271 drinking Nutrition 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 230000004634 feeding behavior Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002555 ionophore Substances 0.000 description 1
- 230000000236 ionophoric Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003340 mental Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000035786 metabolism Effects 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000009304 pastoral farming Methods 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
Abstract
has been found that administering 25-hydroxy vitamin D3 to ruminants helps to eliminate or at least reduce the need for supplemental inorganic P in the diets while maintaining milk production or growth performance. Furthermore, the excretion of P with the manure will be reduced and thus a positive effect on the environment will be achieved. Thus one aspect of this invention is a method of promoting phosphorus utilization in ruminants, comprising administering a sufficient amount of 25-hydroxy vitamin D3 to the animal, preferably as a feed additive. Another aspect of the invention relates to the use of a 25-hydroxy vitamin D3 for promoting or improving phosphorous utilization in ruminants and for reducing the excretion of P via faeces and urine. e effect on the environment will be achieved. Thus one aspect of this invention is a method of promoting phosphorus utilization in ruminants, comprising administering a sufficient amount of 25-hydroxy vitamin D3 to the animal, preferably as a feed additive. Another aspect of the invention relates to the use of a 25-hydroxy vitamin D3 for promoting or improving phosphorous utilization in ruminants and for reducing the excretion of P via faeces and urine.
Description
USE OF 25-HYOROXY VITAMIN D3 TO PROMOTE PHOSPHOROUS
UTILISATION IN RUMINANTS
It is well recognized that animals respond to Phosphorous (P) supplementation in terms of
improved r fertility, improved frame size and growth rates. Large areas of grazing
land around the world in particular Sth Africa, Sth America and Northern Australia are
ely Phosphorus deficient. Supplementation with Phosphorus is commonly used to
improve animal productivity in these areas.
A large amount of phosphate is also present in animal feed in form of phytate
phosphorus. In particular, the alkali or earth alkali salts of phytic acid occur naturally
mainly in grains and s.
Phosphorous present in the diet not absorbed and not incorporated into tissue or milk is
excreted via faeces and urine. The presence of P in manure has serious environmental
consequences, and some countries have enacted strict legal ls on the amount of
P which can be t in manure.
It is an aspect of the present invention to suggest a method of promoting or improving
phosphorous utilization in ruminants which also reduces the level of phosphorous
pollution of the environment
In accordance with the present invention it has been found that administering 25-hydroxy
vitamin D3 to ruminants helps to increase Phosphorus absorption and maintain higher
blood Phosphorus concentrations in cattle offered a low Phosphorus diet. This may also
eliminate or at least to reduce the need for supplemental inorganic P in the diets while
maintaining milk production or growth performance. Furthermore, the excretion of P with
the manure will be d and thus a positive effect on the environment will be achieved.
Thus one aspect of this invention is a method of promoting phosphorus utilization in
ruminants, comprising administering a ient amount of 25-hydroxy vitamin D3 to the
animal.
Another aspect of the invention relates to a method of promoting phosphorous utilization in
a ruminant animal and reducing phosphorous concentration in the excrement of the
animal, comprising administering a ient amount of 25-hydroxy n D3 to the
.
Another aspect of the ion relates to the use of a 25-hydroxy n D3 for improving
phosphorous utilization in ruminants and for reducing the excretion of P via faeces and
urine.
Another aspect of the invention relates to use of 25-hydroxy-vitamin D3 for promoting
orous utilization in a ruminant animal and reducing orous concentration in
the excrement of the animal.
As used throughout the specification and claims, "25-OH D3" means 25-hydroxy
n D3.
The discussion of documents, acts, materials, devices, articles and the like is included in
this specification solely for the purpose of providing a context for the present invention. It
is not suggested or ented that any or all of these matters formed part of the prior art
base or were common general knowledge in the field relevant to the present invention as
it existed before the priority date of each claim of this application.
Where the terms "comprise", "comprises", "comprised" or "comprising" are used in this
specification (including the claims) they are to be reted as ying the presence
of the stated features, integers, steps or components, but not precluding the presence of
one or more other features, integers, steps or components, or group thereof.
There are about 150 species of nts which include both domestic and wild
s. Ruminants include cattle (bovines), goats, sheep and camels. Preferred
ruminants according to this invention are , for example dairy cows and beef cattle.
While many benefits of supplementing a diet with Vitamin 0 and/or 25-OH D3 are
previously described, especially ing bone health, little is known about Vitamin 0
and its derivatives' effect on phosphorus utilization in the animal.
For example, Tritsch et al. (US 2003/0170324) disclose a feed premix composition of at
least 25-OH D3 in an amount between 5% and 50% ) dissolved in oil and an
antioxidant, an agent encapsulating droplets of 25-OH D3 and oil, and a nutritional
ve (e.g., Vitamin D3 ). The premix may be added to poultry, swine, canine, or feline
feed. This composition stabilizes 25-OH D3 against oxidation.
Simoes-Nunes et al. (US 2005/0064018) discloses adding a combination of 25-OH D3
and Vitamin D3 to animal feed. In particular, about 10 µg/kg to about 1OOµg/kg of 25-OH
D3 and about 200 IU/kg to about 4,000 IU/kg of Vitamin D3 are added to swine feed.
This addition improves the ruminant's bone strength.
- 2a -
Stark et al. (US 5,695,794) disclose adding a ation of 25-OH D3 and Vitamin D3
to poultry feed to rate the effects of tibial ndroplasia.
Borenstein et al US 5,043, 170 discloses the combination of Vitamin D3 and either 1-
alpha-hydroxycholecalciferol or 1-alpha, 25-dihydroxycholecalciferol to e egg
strength and leg strength in laying hens and older hens.
While not wishing to be bound by theory, it appears that 25-OH D3 shows an effect on P
metabolism in two ways: On one hand it stimulates P absorption from the gastrointestinal
tract and on the other hand it improves bioavailability of P into tissues.
For the purposes of the invention, 25-OH D3 is suitably administered as supplement to
animal feed. Feed may be supplemented by admixing 25-OH D3, e.g., as a
commercial formulation such as available under the Trademark ROVIMIX® Hy·O®
1.25% to regular feed or by first preparing a premix of a feed
WO 60216
component and 25-OH D3 and subsequent mixing the premix with other feed
components. The feed can be any conventional ruminant feed. The term feed as
used herein comprises both solid and liquid feed as well as drinking fluids such as
drinking water.
Particularly, 25-OH D3 can be administered to the animal in form of a slow release
bolus either alone or with other compounds such as rumen modifiers, ionophores,
methane inhibitors etc or as a formulated powder to a premix containing other
minerals, vitamins, amino acids and trace elements which premix is added to
regular animal feed and thorough mixing to e even distribution n.
Generally, 25-OH D3 is added to the feed in an amount required to administer
from about 0.1 ug to about 5.0 ug, especially about 0.5 ug to about 3.0 ug 25-OH
D3 per kg body weight of an dual animal per day.
More specifically, in the manufacture of a ruminant feed in accordance with the
ion, from about 10 ug/kg to about 1000 ug/kg of 25-OH D3 are suitably
added to r ruminant feed. Alternatively, a feed premix may be prepared on
the basis of regular feed components by adding active ingredients to such feed
components in higher concentration, e.g., in a tration of from about 10
mg/kg to about 1000 mg/kg of 25-OH D3. If one kg of such premix is added per
1000 kg of regular feed this would typically meet the individual need of the animal
by normal feed consumption.
For dairy cows and beef cattle, the dosage can range from about 10 ug to about
1000 pg per kg cattle feed diet, preferably from about 50 to about 80 ug 25-OH D3
per kg diet. For other ruminants, the amounts are similar, and can be based on the
amount of feed given per day. For optimum results, the 25-OH supplementation
should be part of a diet which contains an adequate supply of nutrients, generally
known to be of benefit to the organism.
The efficiency of the treatment of cattle in accordance with the invention can be
seen from the experiments described below.
In an experimental cattle farm, two groups of animals were selected for the
following experiment with a low Phosphorous diet.
One group received the control diet which was the standard roughage diet without
the supplementation of 25-hydroxy-vitamin D3_ The other group received the
mental diet which was the standard roughage diet supplemented with 2,000
ug 25-hydroxy-vitamin D3 per head/day
After 1, 11, 12, 13 and 14 days the blood plasma concentration of phosphorous
was measured by standard method. The results (Figure 1) show a significant
increase in phosphorous concentration in blood plasma for the group with the
experimental diet at least after 10 days.
Additionally the phosphorous concentration in g/day was measured or/calculated
in the diet, faeces and urine. The results are summarized in the table below and
are consistent with measured plasma concentrations as shown in Figure 1. The
s also show a significant decrease of P ion by the animal after 25-OH
D3 supplementation.
-mm--m
Claims (14)
1. A method of promoting phosphorous utilization in a ruminant animal and reducing orous concentration in the ent of the animal, comprising 5 administering a sufficient amount of 25-hydroxy vitamin D3 to the animal.
2. A method according to claim 1 wherein the ruminant is selected from the group consisting of cattle, goats, sheep and camels. 10
3. A method according to claim 1 or claim 2 wherein 25-hydroxy-vitamin D3 is added to the feed in an amount required to administer from about 0.1 µg to about 5.0 µg, ally about 0.5 µg to about 3.0 µg of 25-hydroxy-vitamin D3 per kg body weight of an individual animal per day. 15
4. A method according to any one of claims 1 to 3 wherein the amount of 25- hydroxy Vitamin D3 administered to the animal is from about 10 µg to about 1000 µg per kg feed.
5. A method according to claim 4 wherein the amount is from about 50 µg to about 20 80 µg per kg feed.
6. A method according to any one of claims 1 to 5 wherein 25-hydroxy-vitamin D3 is administered as a feed ment. 25
7. Use of 25-hydroxy-vitamin D3 for promoting phosphorous utilization in a ruminant animal and reducing phosphorous tration in the excrement of the animal.
8. The use according to claim 7 n the ruminant is selected from the 30 group consisting of cattle, goats, sheep and camels
9. The use according to claim 7 or claim 8 wherein 25-hydroxy-vitamin D3 is added to the feed in an amount required to administer from about 0.1 µg to about 5.0 µg, especially about 0.5 µg to about 3.0 µg of 25-hydroxy-vitamin D3 per kg body weight of 35 an individual animal per day.
10. The use according to any one of claims 7 to 9 n 25-hydroxy-vitamin D3 is added to the feed in an amount of about 10 µg to about 1000 µg per kg feed.
11. The use according to claim 10, wherein 25-hydroxy-vitamin D3 is added to the feed in an amount from about 50 µg to about 80 µg per kg feed. 5
12. The use according to any one of claims 7 to 11 n 25-hydroxy-vitamin D3 is administered as a feed supplement.
13. The method according to claim 1, substantially as hereinbefore described, with reference to the examples or .
14. The use according to claim 7, substantially as hereinbefore described, with reference to the examples or figures. W0
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11167576.5 | 2011-05-26 | ||
| EP11167576 | 2011-05-26 | ||
| PCT/EP2012/059996 WO2012160216A1 (en) | 2011-05-26 | 2012-05-29 | Use of 25-hydroxy vitamin d3 to promote phosphorous utilisation in ruminants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NZ617576A NZ617576A (en) | 2014-10-31 |
| NZ617576B2 true NZ617576B2 (en) | 2015-02-03 |
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