NZ612894B2 - Agricultural compositions comprising oil-in-water emulsions - Google Patents
Agricultural compositions comprising oil-in-water emulsions Download PDFInfo
- Publication number
- NZ612894B2 NZ612894B2 NZ612894A NZ61289412A NZ612894B2 NZ 612894 B2 NZ612894 B2 NZ 612894B2 NZ 612894 A NZ612894 A NZ 612894A NZ 61289412 A NZ61289412 A NZ 61289412A NZ 612894 B2 NZ612894 B2 NZ 612894B2
- Authority
- NZ
- New Zealand
- Prior art keywords
- composition
- oil
- active
- active agent
- oily globules
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 91
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 40
- 239000000839 emulsion Substances 0.000 title abstract description 33
- 239000004094 surface-active agent Substances 0.000 claims abstract description 56
- -1 mitocides Substances 0.000 claims abstract description 51
- 239000007764 o/w emulsion Substances 0.000 claims abstract description 42
- 150000001875 compounds Chemical class 0.000 claims abstract description 33
- 230000002363 herbicidal Effects 0.000 claims abstract description 27
- 239000008346 aqueous phase Substances 0.000 claims abstract description 25
- 239000004009 herbicide Substances 0.000 claims abstract description 25
- 239000004480 active ingredient Substances 0.000 claims abstract description 23
- 241000607479 Yersinia pestis Species 0.000 claims abstract description 20
- 239000012071 phase Substances 0.000 claims abstract description 20
- 230000000855 fungicidal Effects 0.000 claims abstract description 8
- 239000000417 fungicide Substances 0.000 claims abstract description 8
- 239000002245 particle Substances 0.000 claims abstract description 7
- 230000000844 anti-bacterial Effects 0.000 claims abstract description 5
- 239000003899 bactericide agent Substances 0.000 claims abstract description 5
- 239000011780 sodium chloride Substances 0.000 claims description 27
- 150000003839 salts Chemical class 0.000 claims description 19
- 230000000749 insecticidal Effects 0.000 claims description 12
- 239000002917 insecticide Substances 0.000 claims description 12
- 239000005468 Aminopyralid Substances 0.000 claims description 9
- NIXXQNOQHKNPEJ-UHFFFAOYSA-N Aminopyralid Chemical compound NC1=CC(Cl)=NC(C(O)=O)=C1Cl NIXXQNOQHKNPEJ-UHFFFAOYSA-N 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 9
- 229910052783 alkali metal Inorganic materials 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 8
- 159000000000 sodium salts Chemical class 0.000 claims description 8
- MEFQWPUMEMWTJP-UHFFFAOYSA-N Fluroxypyr Chemical compound NC1=C(Cl)C(F)=NC(OCC(O)=O)=C1Cl MEFQWPUMEMWTJP-UHFFFAOYSA-N 0.000 claims description 7
- 150000007513 acids Chemical class 0.000 claims description 7
- 150000001412 amines Chemical class 0.000 claims description 7
- 229920001400 block copolymer Polymers 0.000 claims description 7
- 239000005627 Triclopyr Substances 0.000 claims description 6
- REEQLXCGVXDJSQ-UHFFFAOYSA-N Triclopyr Chemical compound OC(=O)COC1=NC(Cl)=C(Cl)C=C1Cl REEQLXCGVXDJSQ-UHFFFAOYSA-N 0.000 claims description 6
- 230000003115 biocidal Effects 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- KAATUXNTWXVJKI-NSHGMRRFSA-N (1R)-cis-(alphaS)-cypermethrin Chemical compound CC1(C)[C@@H](C=C(Cl)Cl)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-NSHGMRRFSA-N 0.000 claims description 5
- ATFFFUXLAJBBDE-FQEVSTJZSA-N (2S)-2-(octadecanoylamino)pentanedioic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC(O)=O ATFFFUXLAJBBDE-FQEVSTJZSA-N 0.000 claims description 5
- 239000005631 2,4-D Substances 0.000 claims description 5
- 241000894006 Bacteria Species 0.000 claims description 5
- 125000000129 anionic group Chemical group 0.000 claims description 5
- 239000003139 biocide Substances 0.000 claims description 5
- 150000003904 phospholipids Chemical class 0.000 claims description 5
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 5
- ZXQYGBMAQZUVMI-GCMPRSNUSA-N γ-cyhalothrin Chemical compound CC1(C)[C@@H](\C=C(/Cl)C(F)(F)F)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-GCMPRSNUSA-N 0.000 claims description 5
- 239000005558 Fluroxypyr Substances 0.000 claims description 4
- 239000005595 Picloram Substances 0.000 claims description 4
- NQQVFXUMIDALNH-UHFFFAOYSA-N Picloram Chemical compound NC1=C(Cl)C(Cl)=NC(C(O)=O)=C1Cl NQQVFXUMIDALNH-UHFFFAOYSA-N 0.000 claims description 4
- 125000002091 cationic group Chemical group 0.000 claims description 4
- CYFHLEMYBPQRGN-UHFFFAOYSA-M ditetradecyl phosphate Chemical class CCCCCCCCCCCCCCOP([O-])(=O)OCCCCCCCCCCCCCC CYFHLEMYBPQRGN-UHFFFAOYSA-M 0.000 claims description 4
- 230000001069 nematicidal Effects 0.000 claims description 4
- 239000005645 nematicide Substances 0.000 claims description 4
- 239000003128 rodenticide Substances 0.000 claims description 4
- 239000002424 termiticide Substances 0.000 claims description 4
- ROBSGBGTWRRYSK-SNVBAGLBSA-N (2R)-2-[4-(4-cyano-2-fluorophenoxy)phenoxy]propanoic acid Chemical compound C1=CC(O[C@H](C)C(O)=O)=CC=C1OC1=CC=C(C#N)C=C1F ROBSGBGTWRRYSK-SNVBAGLBSA-N 0.000 claims description 3
- GOCUAJYOYBLQRH-MRVPVSSYSA-N (2S)-2-(4-{[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOXY)PROPANOIC ACID Chemical compound C1=CC(O[C@H](C)C(O)=O)=CC=C1OC1=NC=C(C(F)(F)F)C=C1Cl GOCUAJYOYBLQRH-MRVPVSSYSA-N 0.000 claims description 3
- RLLPVAHGXHCWKJ-HKUYNNGSSA-N (3-phenoxyphenyl)methyl (1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate Chemical compound CC1(C)[C@@H](C=C(Cl)Cl)[C@H]1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-HKUYNNGSSA-N 0.000 claims description 3
- NIOPZPCMRQGZCE-WEVVVXLNSA-N 2,4-dinitro-6-(octan-2-yl)phenyl (E)-but-2-enoate Chemical compound CCCCCCC(C)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1OC(=O)\C=C\C NIOPZPCMRQGZCE-WEVVVXLNSA-N 0.000 claims description 3
- GOCUAJYOYBLQRH-UHFFFAOYSA-N 2-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxyphenoxy]propanoic acid Chemical compound C1=CC(OC(C)C(O)=O)=CC=C1OC1=NC=C(C(F)(F)F)C=C1Cl GOCUAJYOYBLQRH-UHFFFAOYSA-N 0.000 claims description 3
- RQDJADAKIFFEKQ-UHFFFAOYSA-N 4-(4-chlorophenyl)-2-phenyl-2-(1,2,4-triazol-1-ylmethyl)butanenitrile Chemical compound C1=CC(Cl)=CC=C1CCC(C=1C=CC=CC=1)(C#N)CN1N=CN=C1 RQDJADAKIFFEKQ-UHFFFAOYSA-N 0.000 claims description 3
- 239000005877 Alpha-Cypermethrin Substances 0.000 claims description 3
- 239000005884 Beta-Cyfluthrin Substances 0.000 claims description 3
- 239000005874 Bifenthrin Substances 0.000 claims description 3
- SBPBAQFWLVIOKP-UHFFFAOYSA-N Chlorpyrifos Chemical compound CCOP(=S)(OCC)OC1=NC(Cl)=C(Cl)C=C1Cl SBPBAQFWLVIOKP-UHFFFAOYSA-N 0.000 claims description 3
- 239000005945 Chlorpyrifos-methyl Substances 0.000 claims description 3
- 239000005500 Clopyralid Substances 0.000 claims description 3
- HUBANNPOLNYSAD-UHFFFAOYSA-N Clopyralid Chemical compound OC(=O)C1=NC(Cl)=CC=C1Cl HUBANNPOLNYSAD-UHFFFAOYSA-N 0.000 claims description 3
- KAATUXNTWXVJKI-UHFFFAOYSA-N Cypermethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-UHFFFAOYSA-N 0.000 claims description 3
- 239000005946 Cypermethrin Substances 0.000 claims description 3
- 239000005775 Fenbuconazole Substances 0.000 claims description 3
- NYPJDWWKZLNGGM-UHFFFAOYSA-N Fenvalerate Chemical compound C=1C=C(Cl)C=CC=1C(C(C)C)C(=O)OC(C#N)C(C=1)=CC=CC=1OC1=CC=CC=C1 NYPJDWWKZLNGGM-UHFFFAOYSA-N 0.000 claims description 3
- 239000005903 Gamma-cyhalothrin Substances 0.000 claims description 3
- 239000005565 Haloxyfop-P Substances 0.000 claims description 3
- 239000005806 Meptyldinocap Substances 0.000 claims description 3
- 239000005811 Myclobutanil Substances 0.000 claims description 3
- HZJKXKUJVSEEFU-UHFFFAOYSA-N Myclobutanil Chemical compound C=1C=C(Cl)C=CC=1C(CCCC)(C#N)CN1C=NC=N1 HZJKXKUJVSEEFU-UHFFFAOYSA-N 0.000 claims description 3
- 229960000490 Permethrin Drugs 0.000 claims description 3
- 229940067631 Phospholipids Drugs 0.000 claims description 3
- 230000018199 S phase Effects 0.000 claims description 3
- ZXQYGBMAQZUVMI-BWHPXCRDSA-N [cyano-(3-phenoxyphenyl)methyl] (1S,3S)-3-[(Z)-2-chloro-3,3,3-trifluoroprop-1-enyl]-2,2-dimethylcyclopropane-1-carboxylate Chemical compound CC1(C)[C@H](\C=C(/Cl)C(F)(F)F)[C@@H]1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-BWHPXCRDSA-N 0.000 claims description 3
- HRBKVYFZANMGRE-UHFFFAOYSA-N chlorpyrifos-methyl Chemical group COP(=S)(OC)OC1=NC(Cl)=C(Cl)C=C1Cl HRBKVYFZANMGRE-UHFFFAOYSA-N 0.000 claims description 3
- QQODLKZGRKWIFG-UHFFFAOYSA-N cyfluthrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OC(C#N)C1=CC=C(F)C(OC=2C=CC=CC=2)=C1 QQODLKZGRKWIFG-UHFFFAOYSA-N 0.000 claims description 3
- 229960005424 cypermethrin Drugs 0.000 claims description 3
- RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical class CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 claims description 3
- 229940093541 dicetylphosphate Drugs 0.000 claims description 3
- 229920000578 graft polymer Polymers 0.000 claims description 3
- 159000000001 potassium salts Chemical class 0.000 claims description 3
- OMFRMAHOUUJSGP-IRHGGOMRSA-N κ-bifenthrin Chemical compound C1=CC=C(C=2C=CC=CC=2)C(C)=C1COC(=O)[C@@H]1[C@H](\C=C(/Cl)C(F)(F)F)C1(C)C OMFRMAHOUUJSGP-IRHGGOMRSA-N 0.000 claims description 3
- 239000005944 Chlorpyrifos Substances 0.000 claims description 2
- AVTXVDFKYBVTKR-DPAQBDIFSA-N [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] dihydrogen phosphate Chemical compound C1C=C2C[C@@H](OP(O)(O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 AVTXVDFKYBVTKR-DPAQBDIFSA-N 0.000 claims description 2
- 239000005910 lambda-Cyhalothrin Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- ZZRCKSSPGJOTEE-UHFFFAOYSA-L disodium;carbamoyl phosphate Chemical compound [Na+].[Na+].NC(=O)OP([O-])([O-])=O ZZRCKSSPGJOTEE-UHFFFAOYSA-L 0.000 claims 1
- 230000001717 pathogenic Effects 0.000 claims 1
- 244000052769 pathogens Species 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000000575 pesticide Substances 0.000 abstract description 5
- 241000196324 Embryophyta Species 0.000 description 28
- 239000003921 oil Substances 0.000 description 25
- 235000019198 oils Nutrition 0.000 description 25
- 238000009472 formulation Methods 0.000 description 22
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 20
- 241000238631 Hexapoda Species 0.000 description 16
- 125000004432 carbon atoms Chemical group C* 0.000 description 14
- 229920000642 polymer Polymers 0.000 description 8
- 239000004615 ingredient Substances 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 150000002500 ions Chemical class 0.000 description 6
- 239000000654 additive Substances 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 5
- 230000000240 adjuvant Effects 0.000 description 5
- 230000001351 cycling Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000004062 sedimentation Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 239000003549 soybean oil Substances 0.000 description 5
- 235000012424 soybean oil Nutrition 0.000 description 5
- 229940117927 Ethylene Oxide Drugs 0.000 description 4
- 235000013601 eggs Nutrition 0.000 description 4
- 239000003986 organophosphate insecticide Substances 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N oxane Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 4
- 150000003254 radicals Chemical class 0.000 description 4
- 239000002689 soil Substances 0.000 description 4
- 235000015112 vegetable and seed oil Nutrition 0.000 description 4
- 239000008158 vegetable oil Substances 0.000 description 4
- 241000238876 Acari Species 0.000 description 3
- 235000010469 Glycine max Nutrition 0.000 description 3
- 241000229754 Iva xanthiifolia Species 0.000 description 3
- 150000008055 alkyl aryl sulfonates Chemical group 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000000670 limiting Effects 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 3
- GOOHAUXETOMSMM-UHFFFAOYSA-N propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 description 2
- OVSKIKFHRZPJSS-UHFFFAOYSA-N 2,4-Dichlorophenoxyacetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-UHFFFAOYSA-N 0.000 description 2
- IVDRCZNHVGQBHZ-UHFFFAOYSA-N 2-butoxyethyl 2-(3,5,6-trichloropyridin-2-yl)oxyacetate Chemical compound CCCCOCCOC(=O)COC1=NC(Cl)=C(Cl)C=C1Cl IVDRCZNHVGQBHZ-UHFFFAOYSA-N 0.000 description 2
- DMSMPAJRVJJAGA-UHFFFAOYSA-N Benzisothiazolinone Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 description 2
- GZUXJHMPEANEGY-UHFFFAOYSA-N Bromomethane Chemical compound BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 2
- QQODLKZGRKWIFG-QSFXBCCZSA-N Cyfluthrin Chemical compound CC1(C)[C@@H](C=C(Cl)Cl)[C@H]1C(=O)O[C@@H](C#N)C1=CC=C(F)C(OC=2C=CC=CC=2)=C1 QQODLKZGRKWIFG-QSFXBCCZSA-N 0.000 description 2
- MNNHAPBLZZVQHP-UHFFFAOYSA-M Diammonium phosphate Chemical compound [NH4+].[NH4+].[O-]P([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-M 0.000 description 2
- 240000007842 Glycine max Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000005822 Propiconazole Substances 0.000 description 2
- STJLVHWMYQXCPB-UHFFFAOYSA-N Propiconazole Chemical compound O1C(CCC)COC1(C=1C(=CC(Cl)=CC=1)Cl)CN1N=CN=C1 STJLVHWMYQXCPB-UHFFFAOYSA-N 0.000 description 2
- 229940035295 Ting Drugs 0.000 description 2
- 239000000642 acaricide Substances 0.000 description 2
- 150000001242 acetic acid derivatives Chemical class 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 150000001450 anions Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical class [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 229960001591 cyfluthrin Drugs 0.000 description 2
- 229910000388 diammonium phosphate Inorganic materials 0.000 description 2
- 235000019838 diammonium phosphate Nutrition 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 150000004820 halides Chemical class 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 150000003893 lactate salts Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 125000006353 oxyethylene group Chemical group 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 150000008103 phosphatidic acids Chemical class 0.000 description 2
- 230000003032 phytopathogenic Effects 0.000 description 2
- 230000002633 protecting Effects 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-M stearate Chemical compound CCCCCCCCCCCCCCCCCC([O-])=O QIQXTHQIDYTFRH-UHFFFAOYSA-M 0.000 description 2
- 239000003760 tallow Substances 0.000 description 2
- WMMQJAQJAPXWDO-UHFFFAOYSA-N (4-chlorophenyl) N-methylcarbamate Chemical compound CNC(=O)OC1=CC=C(Cl)C=C1 WMMQJAQJAPXWDO-UHFFFAOYSA-N 0.000 description 1
- UKSLKNUCVPZQCQ-GZTJUZNOSA-N (E)-1-(4-chlorophenyl)-N-(1,3-dioxolan-2-ylmethoxy)-2,2,2-trifluoroethanimine Chemical compound C=1C=C(Cl)C=CC=1/C(C(F)(F)F)=N\OCC1OCCO1 UKSLKNUCVPZQCQ-GZTJUZNOSA-N 0.000 description 1
- MZHCENGPTKEIGP-RXMQYKEDSA-N (R)-dichlorprop Chemical compound OC(=O)[C@@H](C)OC1=CC=C(Cl)C=C1Cl MZHCENGPTKEIGP-RXMQYKEDSA-N 0.000 description 1
- RYAUSSKQMZRMAI-ZACQAIPSSA-N (R)-fenpropimorph Chemical compound C([C@H](C)CC=1C=CC(=CC=1)C(C)(C)C)N1C[C@H](C)O[C@H](C)C1 RYAUSSKQMZRMAI-ZACQAIPSSA-N 0.000 description 1
- YUVKUEAFAVKILW-SECBINFHSA-N (R)-fluazifop Chemical compound C1=CC(O[C@H](C)C(O)=O)=CC=C1OC1=CC=C(C(F)(F)F)C=N1 YUVKUEAFAVKILW-SECBINFHSA-N 0.000 description 1
- WNTGYJSOUMFZEP-SSDOTTSWSA-N (R)-mecoprop Chemical compound OC(=O)[C@@H](C)OC1=CC=C(Cl)C=C1C WNTGYJSOUMFZEP-SSDOTTSWSA-N 0.000 description 1
- JLYFCTQDENRSOL-VIFPVBQESA-N (S)-dimethenamid Chemical compound COC[C@H](C)N(C(=O)CCl)C=1C(C)=CSC=1C JLYFCTQDENRSOL-VIFPVBQESA-N 0.000 description 1
- WVQBLGZPHOPPFO-LBPRGKRZSA-N (S)-metolachlor Chemical compound CCC1=CC=CC(C)=C1N([C@@H](C)COC)C(=O)CCl WVQBLGZPHOPPFO-LBPRGKRZSA-N 0.000 description 1
- QNBTYORWCCMPQP-JXAWBTAJSA-N (Z)-dimethomorph Chemical compound C1=C(OC)C(OC)=CC=C1C(\C=1C=CC(Cl)=CC=1)=C/C(=O)N1CCOCC1 QNBTYORWCCMPQP-JXAWBTAJSA-N 0.000 description 1
- MCNOFYBITGAAGM-UHFFFAOYSA-N (±)-Furilazole Chemical compound C1N(C(=O)C(Cl)Cl)C(C)(C)OC1C1=CC=CO1 MCNOFYBITGAAGM-UHFFFAOYSA-N 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N (±)-Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- OWQPOVKKUWUEKE-UHFFFAOYSA-N 1,2,3-benzotriazine Chemical compound N1=NN=CC2=CC=CC=C21 OWQPOVKKUWUEKE-UHFFFAOYSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N 1,2-ethanediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- UOORRWUZONOOLO-UHFFFAOYSA-N 1,3-Dichloropropene Chemical compound ClCC=CCl UOORRWUZONOOLO-UHFFFAOYSA-N 0.000 description 1
- MHULQDZDXMHODA-UHFFFAOYSA-N 1-(2,2-dichloroacetyl)-3,3,8a-trimethyl-2,4,7,8-tetrahydropyrrolo[1,2-a]pyrimidin-6-one Chemical compound C1C(C)(C)CN(C(=O)C(Cl)Cl)C2(C)N1C(=O)CC2 MHULQDZDXMHODA-UHFFFAOYSA-N 0.000 description 1
- HKELWJONQIFBPO-UHFFFAOYSA-N 1-(2,4-dichlorophenyl)-5-(trichloromethyl)-1,2,4-triazole-3-carboxylic acid Chemical compound N1=C(C(=O)O)N=C(C(Cl)(Cl)Cl)N1C1=CC=C(Cl)C=C1Cl HKELWJONQIFBPO-UHFFFAOYSA-N 0.000 description 1
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- 230000000361 pesticidal Effects 0.000 description 1
- 239000003209 petroleum derivative Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 1
- 229920001521 polyalkylene glycol ether Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- XUYNZTABHAFFAO-UHFFFAOYSA-M potassium;4-amino-3,6-dichloropyridine-2-carboxylate Chemical compound [K+].NC1=CC(Cl)=NC(C([O-])=O)=C1Cl XUYNZTABHAFFAO-UHFFFAOYSA-M 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
- JUGKVSNCOWXSFE-UHFFFAOYSA-N pyrimidine;trihydroxy(sulfanylidene)-$l^{5}-phosphane Chemical compound OP(O)(O)=S.C1=CN=CN=C1 JUGKVSNCOWXSFE-UHFFFAOYSA-N 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- KLYDBHUQNXKACI-UHFFFAOYSA-M sodium;2-[2-(2-tridecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O KLYDBHUQNXKACI-UHFFFAOYSA-M 0.000 description 1
- UKNAYQWNMMGCNX-UHFFFAOYSA-N sodium;[hydroxy(phenyl)methyl]-oxido-oxophosphanium Chemical compound [Na+].[O-][P+](=O)C(O)C1=CC=CC=C1 UKNAYQWNMMGCNX-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- REYJJPSVUYRZGE-UHFFFAOYSA-N stearylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 101700082413 tant Proteins 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 230000002588 toxic Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N2300/00—Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
- A01N25/28—Microcapsules or nanocapsules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/06—Unsaturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N39/00—Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or, e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
- A01N39/02—Aryloxy-carboxylic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N39/00—Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or, e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
- A01N39/02—Aryloxy-carboxylic acids; Derivatives thereof
- A01N39/04—Aryloxy-acetic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
- A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
Abstract
Disclosed herein is an oil-in-water emulsion composition having at least one agriculturally active compound, the oil-in-water emulsion composition comprising: A) an oil phase, wherein the oil phase comprises at least one agriculturally active ingredient, said oil phase comprising oily globules, the oily globules having a mean particle diameter of less than about 800 nanometers; and B) an aqueous phase, wherein the oily globules are dispersed in the aqueous phase and wherein at least some of the oily globules dispersed in the aqueous phase are coated with a polymeric adsorption layer, wherein said polymeric adsorption layer consists of: (1) at least one polymeric surface-active agent having an HLB value in the range of about 16 to about 18; and (2) at least one ionic surface-active agent.Agriculturally active ingredients that can be used with the emulsion include, pesticides, herbicides, fungicides, mitocides, bactericides and the like. Also disclosed are methods of using the oil-in-water emulsions to treat plants and on surfaces adjacent to plants, plant pests or other pests. oily globules having a mean particle diameter of less than about 800 nanometers; and B) an aqueous phase, wherein the oily globules are dispersed in the aqueous phase and wherein at least some of the oily globules dispersed in the aqueous phase are coated with a polymeric adsorption layer, wherein said polymeric adsorption layer consists of: (1) at least one polymeric surface-active agent having an HLB value in the range of about 16 to about 18; and (2) at least one ionic surface-active agent.Agriculturally active ingredients that can be used with the emulsion include, pesticides, herbicides, fungicides, mitocides, bactericides and the like. Also disclosed are methods of using the oil-in-water emulsions to treat plants and on surfaces adjacent to plants, plant pests or other pests.
Description
AGRICULTURAL ITIONS COMPRISING OIL-IN-WATER EMULSIONS
CROSS REFERENCE TO D APPLICATIONS
This application claims the benefit of US. Provisional Patent Application
Serial No. ,878 filed Ianuary 14, 2011, which is incorporated herein by reference
in its entirity.
FIELD OF THE INVENTION
The present ion relates to stable, agricultural oil-in-water emulsion
compositions.
BACKGROUND
Concentrated oil—in water emulsions of liquid active ingredients or active
ingredients dissolved in a solvent are commonly used in agricultural compositions due to
certain advantages provided over other formulation types. Emulsions are water based,
contain little or no solvent, allow mixtures of active ingredients to be combined into a single
formulation and are compatible with a wide range of packaging material. However, there are
also several disadvantages of such ltural ons, for example, they are often
complex formulations which require high amounts of surface-active agents for stabilization,
are generally very viscous, have a cy for Oswald ng of the emulsion globules and
separate over time. Therefore, improvements in such emulsion formulations are needed in
the agricultural field.
Several oil—in—water emulsion compositions for cosmetics and dermatological
applications have been described in patents US. 5,658,575; US. 5,925,364; US. 5,753,241;
US. 5,925,341; US. 6,066,328; US. 6,120,778; US. 6,126,948; US. 6,689,371; US.
6,419,946; US. 6,541,018; US. 6,335,022; US. 150; US. 6,375,960; US. 6,464,990;
US. 6,413,527; US. 6,461,625; and US. 6,902,737; all of which are incorporated herein by
reference. However, although these types of emulsions have found advantageous use in
al care products, these types of emulsions have not been widely used with
agriculturally active compounds, which are typically present in emulsions at much higher
levels than cosmetic active ingredients.
SUMNLARY
Some embodiments of the invention include an oil—in—water emulsion
composition having at least one agriculturally active compound, the oil-in-water emulsion
composition sing: A) an oil phase, wherein the oil phase es at least one
agriculturally active ingredient and is comprised essentially of oily globules, the oily globules
having a mean particle diameter of less than about 800 nanometers; and B) an aqueous phase,
wherein the oily es are dispersed in the s phase and n at least some of the
oily globules dispersed in the s phase are coated with a polymeric adsorption layer,
wherein said polymeric adsorption layer ses: (1) at least one polymeric surface-active
agent having an HLB value in the range of about 16 to about 18; and (2) at least one ionic
surface—active agent. In some ment the aqueous phase includes a second polymeric
surface active agent having an HLB in the range of about 12 to about 14. In some
embodiments the polymeric surface—active agent is selected from the group consisting of:
amphipathic block and graft copolymers.
In some embodiments the aqueous phase includes a non—ionic, non—polymeric
surface active agent. In some embodiments the ionic e-active agent in the compositon
is selected from the group consisting of: (a) neutralized anionic surface-active agents,
(b) amphoteric surface-active agents, (c) alkylsulphonic derivatives and (d) cationic surface-
active agents.
In some embodiments the ionic surface—active agent in the composition is
selected from the group consisting of: alkali metal salts of dicetyl phosphate and dimyristyl
phosphate, in particular sodium and potassium salts; alkali metal salts of cholesteryl te
and cholesteryl ate, especially the sodium salts; lipoamino acids and their salts, such
as mono— and disodium acylglutamates, such as the um salt of N—stearoyl-L-glutamic
acid, the sodium salts of phosphatidic acid; phospholipids; the mono- and disodium salts of
acylglutamic acids, in particular N—stearoylglutamic acid; and alkyl ether citrates. In some
embodiments the composition of Claim 4, wherein the ionic surface-active agent is a
phospholipid. In some embodiments the ionic surface-active agent is an alkylsulphonic
derivative. And in some embodiments the ionic surface-active agent is selected from the
group consisting of quaternary ammonium salts, fatty amines and salts thereof.
In some embodiments of the invention the amount of the polymeric surface—
active agents (1) in the ition is in the range of about 30 to about 95 wt. % of the total
of both (1) and (2). In still other embodiments of the invention the amount of the polymeric
surface-active agents (1) in the composition is in the range of about 50 to about 95, weight
percent of the total of both (1) and (2). And in still other emodiments of the invention the
amount of the ionic surface active agent (2) in the composition is in the range of about 5 to
about 50 wt. % of the total combined weight of (1) and (2).
In some embodiments of the invention the amount of the ionic surface active
agent (2) in the composition is in the range of about 10 to about 50 wt. % of the total
combined weight of (1) and (2).
In some embodiments of the invention the coating on the oily globules
ses between about 0.5 wt. % to about 20 wt. % based on the total weight of the oil—in—
water emulsion. In still other embodiments the coating on the oily globules comprises
between about 0.5 wt. % to about 10 wt. % based on the total weight of the oil-in—water
emulsion. While in still other embodiments the coating on the oily globules comprises
between about 0.5 wt. % to about 2.5 wt. % based on the total weight of the —water
emulsion.
In some embodiments of the invention the oil-in-water on in the
iton includes at least one lturally active ingredient selected from the group
consisting of: fungicides, insecticides, nematocides, miticides, biocides, termiticides,
icides, arthropodicides, herbicides, bactericides, and bacteria stats.
In some embodiments the inventive the oil-in-water emulsion includes at least
one agriculturally active ingredient ed from the group consisting of: fungicides,
insecticides, nematocides, miticides, es, termiticides, rodenticides, arthropodicides,
herbicides, bactericides, and bacteria stats. In some embodiments the active ingredient is an
herbicide ed from the group consisting of 2,4-D, aminopyralid, clopyralid, cyhalofop,
fluroxypyr, haloxyfop, haloxyfop-P, picloram and triclopyr. In some embodiments the active
ingredient is an insecticide selected from the group consisting of bifenthrin, chlorpyrifos,
chlorpyrifos-methyl, cyfluthrin, beta-cyfluthrin, cyhalothrin, gamma-cyhalothrin, lambdacyhalothrin
, cypermethrin, alpha-cypermethrin, beta-cypermethrin, fenvalerate and
permethrin. And in some embodiment the ive formulation includeds an active
WO 97149
ingredient that is a ide selected from the group ting of dinocap, fenbuconazole,
meptyl dinocap, myclobutanil and propiconazole.
Some embodiments include methods of treating plants, comprising the steps
of: providing an oil-in-water emulsion according to at least one other embodiment of the
ion. In some embodiments the methods of treating plants, comprises the steps of:
applying an oil-in-water emulsion according to the invnetion to a e wherein the surface
is a portion of at lest one plant and/or a surface adjacnet to at least one plant.
DESCRIPTION
Some aspects of the present invention provide novel formulations of
agriculturally actice ingredients that include oil and water emulstion which demonstrate
better stability than many currently availabe emulsion formuated for agriculturaral use. Some
example, some aspect of the t invention include oil-in-water emulsion composition
comprising:
an oil phase, which comprises oily es comprising at least one compound
which is agriculturally active; and an aqueous phase; wherein the oily globules are dispersed
in the aqueous phase and stabilized by a polymeric adsorption layer which comprises: (1) at
least one polymeric surface-active agent having an HLB value between 16 and 18, and (2) at
least one ionic surface-active agent, and wherein the oily globules having a mean particle
diameter of less than 800 nanometers.
Unless stated otherwise the term, 'about' as used herein means plus or minus
percent, e. g. about 2.0 includes values between 1.6 and 2.4.
The oil phase (A) of the oil-in-water emulsion of the present invention utilizes
either an lturally active compound which is in the form of an oil, or alternatively, an
lturally active compound dissolved or mixed in an oil, to form the oily globules. An oil
is a liquid which is not le with water. In this invention, almost any oil which is
compatible with the agriculturally active nd may be used in the oil-in-water
emulsions of the present invention. Unless stated otherwise, the term ‘compatible’ means
that the oil will dissolve or mix uniformly with the agriculturally active compound and allow
for the formation of the oily globules of the oil-in-water emulsion of the t invention.
WO 97149
Exemplary oils for this use include, but are not limited to, short-chain fatty acid triglycerides,
silicone oils, eum fractions or hydrocarbons such as heavy aromatic a solvents,
light aromatic naphtha solvents, hydrotreated light petroleum distillates, paraffinic solvents,
mineral oil, enzenes, paraffinic oils, and the like; vegetable oils such as soy oil, rape
seed oil, coconut oil, cotton seed oil, palm oil, soybean oil, and the like; alkylated vegetable
oils and alkyl esters of fatty acids such as methyloleate and the like.
Unless clearly stated or implied, an agriculturally active compound is herein
defined as any oil, oil e and/or hydrophobic compound which exhibits at least some
pesticidal or biocidal activity; and it is understood to refer to the active compound per se
when it is itself an oil or alternatively, the active compound is dissolved in an oil. Such
compounds or pesticides include fungicides, insecticides, cides, des,
icides, rodenticides, arthropodicides, herbicides, biocides and the like. es of
such agriculturally active ingredients can be found, for example, in The Pesticide Manual,
12th Edition. Exemplary pesticides which can be utilized in the oil-in-water emulsion of the
present invention include, but are not limited to, benzofuranyl methylcarbamate insecticides
such as benfuracarb, and carbosulfan; oxime carbamate insecticides such as aldicarb;
fumigant insecticides such as chloropicrin, 1,3-dichloropropene and methyl bromide; juvenile
hormone mimics such as fenoxycarb; organophosphate icides such as dichlorvos;
aliphatic thiophosphate insecticides such as malathion and terbufos; aliphatic amide
organothiophosphate insecticides such as dimethoate; benzotriazine organothiophosphate
insecticides such as os-ethyl and azinphos-methyl; pyridine organothiophosphate
insecticides such as chlorpyrifos and chlorpyrifos-methyl; pyrimidine thiophosphate
insecticides such as diazinon; phenyl organothiophosphate insecticides such as parathion and
parathion-methyl; pyrethroid ester insecticides such as bifenthrin, cyfluthrin, beta-cyfluthrin,
cyhalothrin, gamma-cyhalothrin, -cyhalothrin, cypermethrin, alpha-cypermethrin,
beta-cypermethrin, fenvalerate, and permethrin; and the like.
Exemplary herbicides which can be used in the oil-in-water emulsion of the
present invention include, but are not limited to: amide herbicides such as dimethenamid and
dimethenamid-P; anilide herbicides such as il; chloroacetanilide herbicides such as
acetochlor, alachlor, butachlor, metolachlor and S-metolachlor; cyclohexene oxime
herbicides such as sethoxydim; dinitroaniline herbicides such as benfluralin, uralin,
pendimethalin, and trifluralin; nitrile herbicides such as bromoxynil ate; phenoxyacetic
herbicides such as 4-CPA, 2,4-D, 3,4-DA, MCPA, and MCPA-thioethyl; phenoxybutyric
herbicides such as 4-CPB, , 3,4-DB, and MCPB; phenoxypropionic herbicides such
as cloprop, 4—CPP, dichlorprop, dichlorprop—P, 3,4—DP, fenoprop, mecoprop and mecoprop—P;
aryloxyphenoxypropionic herbicides such as cyhalofop, fluazifop, fluazifop-P, haloxyfop,
haloxyfop-P; pyridine herbicides such as yralid, clopyralid, fluroxypyr, picloram, and
triclopyr; triazole herbicides such as carfentrazone ethyl; and the like.
Many of the herbicides that can be used to practice the invention can also
generally be employed in combination with known herbicide safeners such as: cor,
cloquintocet, rinil, daimuron, dichlormid, dicyclonon, dietholate, fenchlorazole,
fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, isoxadifen, isoxadifen-ethyl,
yr, mefenpyr-diethyl, MGl9l, MON4660, R29l48, mephenate, naphthalic anhydride,
N—phenylsulfonylbenzoic acid amides and oxabetrinil.
Exemplary fungicides which can be used in the oil-in-water emulsion of the
present invention include, but are not limited to, difenoconazole, dimethomorph, dinocap,
diphenylamine, dodemorph, phos, fenarimol, fenbuconazole, fenpropimorph, meptyl
dinocap, myclobutanil, propiconazole, tebuconazole and the like.
It is understood by those skilled in the art that any combination of
agriculturally active nds may also be used in the oil-in-water emulsion of the present
invention as long as a stable and ive emulsion is still ed.
The amount of agriculturally active ingredient within the oil-in-water
emulsion will vary depending upon the actual active ingredient, the application of the
agriculturally active ient and the appropriate application levels which are well known
to those skilled in the art. Typically, the total amount of agriculturally active ingredient
within the oil-in-water emulsion will be from about 1, generally from about 5, preferably
from about 10, more preferably from about 15 and most preferably from about 20 to about
45, generally to about 40, preferably to about 35 and most preferably to about 30 weight
percent based on the total weight of the oil-in-water emulsion.
The ric surface-active agent in some embodiments has an HLB in the
range of about 16 and about 18. The acronym HLB refers to the term “Hydrophilic
Lipophilic Balance” which identifies an emulsifier’s lity in water or oil. Polymeric
surface—active agents which can be used in the oil-in-water emulsion of the present invention
include amphipathic block or graft copolymers. Preferred polymer surfactants are, but not
limited to, EO/PO block copolymers. Block copolymers of ethylene—oxide (EO) and
propylene—oxide (PO), as well as copolymers of EO and PO from ethylene diamine, are
available in a variety of formulas and from a variety of s, including the T'etronicTM
and PluronicTM polymers from BASFTM, the ToximulTM polymers from TM, the
AtlasTM polymers from aTM, the HartpoXTM polymers from Huntsman
Corporation, as well as other s.
The following is a non-limiting ption of the nonionic block mers
that may be useful herein. Structurally, nonionic block copolymers are characterized by an
EO-PO-EO arrangement. They may have a total hydrophile (EO) content of about at least
% or higher of the total molecular weight. The hydrophilic/lipophilic e (HLB) of
the nonionic block copolymers is about 16 to 18. The molecular weight of the polymeric
tant is y around 2000 to 15,000, preferably around 3000 to 8,000. Examples of
preferable EO-PO polymers are, but not d to, ToximulTM 8323, AtlasTM G5000,
PluronicTM P105, and PluronicTM P85.
In addition to the ric surface-active agent, an ionic surface-active agent
(2) also comprises the polymeric adsorption layer that is physically adsorbed onto the outer
surface of oily globule. Ionic surface—active agents which can be used in the oil—in—water
emulsion of the present invention include compounds such as (a) neutralized anionic surface-
active agents, (b) amphoteric surface-active agents, (c) alkylsulphonic derivatives and (d)
cationic surface—active agents.
Neutralized anionic surface-active agents (a) include, but are not limited to,
for e: alkali metal salts of dicetyl phosphate and dimyristyl phosphate, in particular
sodium and potassium salts; alkali metal salts of cholesteryl sulphate and cholesteryl
phosphate, especially the sodium salts; lipoamino acids and their salts, such as mono- and
disodium acylglutamates, such as the um salt of N—stearoyl-L-glutamic acid, the
sodium salts of phosphatidic acid; phospholipids; and the mono- and disodium salts of
acylglutamic acids, in ular N—stearoylglutamic acid.
Some anionic surface—active agents chosen from alkyl ether citrates and
mixtures thereof which can be used in the oil-in-water emulsions of the present invention are
disclosed in US. 6,413,527, which is incorporated herein by reference. Alkyl ether citrates
include monoesters or diesters formed by citric acid and at least one oxyethylenated fatty
alcohol comprising a saturated or unsaturated, linear or ed alkyl chain having from 8
to 22 carbon atoms and comprising from 3 to 9 oxyethylene groups, and es thereof.
Citrates that can be used to practice the ion include those chosen from the group
consisting of, mono- and diesters of citric acid and of ethoxylated lauryl alcohol comprising
from 3 to 9 oxyethylene groups. The alkyl ether citrates are preferably employed in the
neutralized form at a pH of about 7. Neutralization agents can be chosen from inorganic
bases, such as sodium hydroxide, ium hydroxide or ammonia, and organic bases, such
as mono, - di- and triethanolamine, aminomethyl-l, 3-propanediol, N—methylglucamine, basic
amino acids, such as arginine and lysine and mixtures thereof.
Amphoteric surface-active agents (b) include, but are not limited to,
olipids and especially phosphatidylethanolamine from pure soya.
Alkylsulphonic derivatives (c) include, but are not limited to compounds of
the formula:
R—CH—co—O—(CHZCH20)2—CH3
803M
wherein R represents the radicals Cl6H33 and Cl 8H37, taken as a mixture or separately, and
M is an alkali metal, ably sodium.
Cationic surface—active agents (d) include, but are not limited to, surface—
active agents such as those disclosed in US. 990, which is incorporated herein by
reference. They are typically selected from the group of quaternary ammonium salts, fatty
amines and salts thereof. The quaternary ammonium salts e, for example, those which
exhibit the following formula:
R1 R3 —
:N: X
R2 R4
wherein the R1 to R4 radicals, which can be identical or different, represent a linear or
branched aliphatic radical comprising from 1 to 30 carbon atoms or an ic radical, such
as aryl or alkylaryl. The aliphatic radicals can comprise heteroatoms, such as oxygen,
nitrogen, sulfur and halogens. The aliphatic radicals include alkyl, alkoxy, polyoxy(C2-
C6)alkylene, alkylamido, (C12-C22 )alkyl-amido(C2-C6) alkyl, (C12-C22)alkyl acetate and
hydroxyalkyl radicals sing approximately from 1 to 30 carbon atoms; X is an anion
selected from halides, phosphates, acetates, lactates, (C2—C6)alkyl sulfates, and alkyl— or
alkylarylsulfonates. Preference is given, as quaternary ammonium salts to
tetraalkylammonium chlorides, such as dialkyldimethylammonium and
alkyltrimethylammonium chlorides in which the alkyl radical comprises imately from
12 to 22 carbon atoms, in particularly behenyltrimethyl-ammonium,
ryldimethylammonium, cetyltrimethylammonium and benzyldimethylstearylammonium
chlorides, or alternatively, stearamidopropyl-dimethyl(myristyl acetate) ammonium chloride;
imidazolinium quaternary ammonium salts, such as those of formula:
R6 F|<8 +
N2\N/CH2—CH2—N—CO —R5 _
|_l \R?
wherein R5 represents an alkenyl or alkyl radical comprising from 8 to 30 carbon atoms, for
example derived from tallow fatty acids; R6 represents a en atom, an alkyl radical
comprising from 1 to 4 carbon atoms or an alkenyl or alkyl radical comprising from 8 to 30
carbon atoms; R7 represents an alkyl radical comprising from 1 to 4 carbon atoms; R8
represents a hydrogen atom or an alkyl radical sing from 1 to 4 carbon atoms; and X is
an anion selected from the group of the halides, phosphates, acetates, lactates, alkyl sulfates,
or alkyl, and alkylarylsulfonates. R5 and R6 preferably denote a mixture of l or alkyl
radicals comprising from 12 to 21 carbon atoms, for example, derived from tallow fatty acids,
R7 preferably denotes a methyl radical and R8 preferably denotes hydrogen. Quaternary
nium salts are also contemplated, such as etallowdiammonium dichloride.
Fatty amines include, but are not limited to those of formula:
R9(CONH)n(CH2)mN(R1 1)R10
n R9 is an optionally saturated and/or branched arbon chain, having n 8
and 30 carbon atoms, preferably between 10 and 24 carbon atoms; R10 and R11 are selected
from H and an optionally saturated and/or branched hydrocarbon chain, having between 1
2012/021075
and 10 carbon atoms; preferably between 1 and 4 carbon atoms; m is an integer between 1
and 10 and is preferably between 1 and 5; and n is either 0 or 1.
Examples of fatty amines that can be used to practice the invention include,
but are not limited to, stearylamine, aminoethyl-ethanolamide stearate, diethylenetriamine
stearate, palmitamidopropyldimethyl-amine, palmitamidopropyldiethylamine,
palmitamidoethyldiethylamine, palmitamidoethyldimethylamine. Commercially available
fatty amines include, but are not limited to, IncromineTM BB from Croda, AmidoamineTM
MSP from Nikkol, and LexamineTM series from Inolex, the Acetamine series from Kao
Corp; Berol 380, 390, 453 and 455, and EthomeenTM series from Akzo Nobel, and
MarlazinTM L10, 0L2, OL20, T15/2, T50 from Condea Chemie.
The e-active agents of (l) and (2) form a ric tion layer
surrounding the oily globules suspended within the aqueous phase of the oil—in—water
emulsion of the present invention. The amount of the surface-active agents (1) utilized in the
oil-in-water emulsion of the present invention is typically from 0.1 to 20, preferably from
about 0.5 to about 10, and more preferably to about 2 weight percent, based on the total
weight of the oil-in-water on. The amount of the e-active agents (2) utilized in
the oil-in-water emulsion of the t invention is typically from 0.1 to 20, preferably from
about 0.2 to about 5, and more preferably to about 0.5 weight percent, based on the total
weight of the oil-in-water emulsion.
The ratio of the total weight of the surface-active compounds (1) and (2) to the
total weight of oil is typically from about 1:25 to about 1:30.
The aqueous phase (B) is typically water, for example, deionized water. The
aqueous phase may also contain other additives such as compounds that lower the freezing
point, for example, alcohols, e. g., isopropyl l and propylene glycol; pH buffering
agents, for e, alkali phosphates such as sodium phosphate monobasic monohydrate,
sodium phosphate dibasic; biocides, for example, Proxel GXL; and antifoams, for e
octamethylcyclotetrasiloxane (Antifoam A from Dow Corning). Other additives and/or
adjuvants can also be present in the aqueous phase (B) as long as the stability of the oil—in—
water emulsion is still maintained. Other additives also include soluble agriculturally
active compounds.
The oil phase or the coated oily globules are typical from about 0.1 to about
55, preferably from about 10 to about 50, and more preferably from about 20 to about 45
percent, and most preferably from about 30 to about 40 weight t, based on the total
weight of the oil-in-water on composition. The oil/water ratio is lly less than or
equal to l.
Other additives and/or adjutants can also be present within the oil-in-water
on of the present invention, as long as the stability and activity of the oil-in-water
emulsion is still obtained. Some of the oil-in-water emulsions of the present invention may
contain additional polymeric surface-active agents (3) to improve the performact of the
ons such as the emulsion stability, and low temperature stability performance.
Suitable r surface-active agents may include, but are not limited to, non ionic
polymeric surfactants with HLB value from 12 to 14, such as SoprophorTM 796/P
(Ethopropoxylated Polyarylphenol from Rhodia). Some of the -water emulsions of the
present invention may additionally contain adjuvant surface-active agents to enhance
deposition, wetting and penetration of the agriculturally active ingredient onto the target site,
e. g., crop, weed or organism. These adjuvant surface—active agents may ally be
employed as a component of the emulsion in either phase A or B, or as a tank mix
component; the use of and amount desired being well known by those skilled in the art.
Suitable adjuvant e-active agents include, but are not limited to, ethoxylated nonyl
phenols, ethoxylated synthetic or natural alcohols, salts of the esters or sulphosuccinic acids,
ethoxylated organosilicones, ethoxylated fatty amines and blends of surface-active agents
with mineral or vegetable oils.
The oil—in—water emulsion of the t invention can be prepared, in part,
according to the process described in US. 5,925,364, the teachings of which are incorporated
herein by reference. The mixture may be homogenized by cavitations using a high pressure
homogenizer, to provide the small particle sized oily es. The mean size of the coated
oily globules is typically less than about 800 nanometers, preferably less than about 500
nanometers and more preferably about 200 nanometers, as determined using laser diffraction
le size analysis and scanning electron copy.
In one embodiment, the oil-in-water emulsion is prepared by:
mixing 1) (A) an oil phase, an agriculturally active compound and optionally an oil and (B)
an aqueous phase, comprising water, the polymeric surfactant(s) and the ionic surfactant(s),
to obtain a mixture; and 2) homogenizing the mixture, for example, by subjecting the mixture
to cavitation.
In the first step, the mixture can be formed by conventional ng, for
example, using a high shear homogenizer rotating at a rate of approximately between 2000
and 7000 rpm for a time period of between about 5 to about 15 minutes and at a temperature
of between approximately 20°C and 50°C.
The homogenization step may be performed by using a high pressure
nizer operating at pressures between approximately 200 and 1000 bar as is well
known to those d in the art. The process may be performed by successive passages,
generally from 1 to 4 passages, at an elevated pressure; the mixture gradually being returned
to normal (generally ambient) pressure between each passage. The homogenization of the
second step may also be carried out using other techniques such as ultrasound or by the use
of a homogenizer equipped with a rotor-stator type head.
Other embodiments of the present invention may include the use of the oil-in-
water emulsion in agricultural applications to control, prevent or ate unwanted living
sms, e.g., fungi, weeds, insects, bacteria or other rganisms and other pests. This
use includes its use for protecting a plant against attack by a phytopathogenic organism or the
treatment of a plant y infested by a phytopathogenic organism, comprising the step
ng the oil-in-water emulsion composition, to soil, a plant, a part of a plant, foliage,
flowers, fruit, and/or seeds, or any surface adjacent to a plant in a disease ting and
phytologically acceptable amount. The term "disease inhibiting and phytologically
acceptable amount" refers to an amount of a compound that kills or ts the plant disease
for which control is desired, in an amount not significantly toxic to the plant being treated.
The exact concentration of active compound required varies with the fungal disease to be
controlled, the type of formulations employed, the method of ation, the particular plant
species, climate conditions, and the like, as is well known in the art.
Additionally, the oil-in-water ons of the present invention are useful for
the control of insects or other pests, e. g., s. Therefore, the present invention also is
directed to a method for inhibiting an insect or other pest, such as mites, which comprises
WO 97149 2012/021075
applying to a locus of the insect or pest an oil-in-water emulsion comprising an insectinhibiting
amount of an agriculturally active compound for such use. The "locus" of insects
or pests is a term used herein to refer to the environment in which the insects or other pests
live or where their eggs are present, including the air surrounding them, the food they eat, or
objects which they contact. For example, insects which eat or contact crop or other desirable
plants can be controlled by applying the active compound to plant parts such as the seed,
seedling, or cutting which is planted, the leaves, stems, , grain, or roots, to the soil in
which the roots are g or to any surfaces adjacent to the ble plants. It is
contemplated that the agriculturally active compounds and oil-in-water emulsions ning
such, might also be useful to protect textiles, paper, stored grain, seeds, domesticated
animals, buildings or human beings by applying an active compound to or near such objects.
The term "inhibiting an insect or pest" refers to a decrease in the numbers of living insects or
other pests in any stage of their life cycle, or a decrease in the number of viable insect or
other pest eggs. The extent of reduction accomplished by a compound depends, of course,
upon factors including the application rate of the compound, the particular compound used,
and the target insect or pest species and the like. At least an inactivating amount should be
used in at least one ation of the material. The terms "insect or pest-inactivating
amount" are used to describe the amount, which is sufficient to cause a able reduction
in the d insect or pest population, as is well known in the art.
The locus to which a compound or composition is applied can be any locus
inhabited by an insect, mite or pest, for example, vegetable crops, fruit and nut trees, grape
vines, ornamental plants, domesticated animals, plants grown for fuel, wood or fiber, the
interior or exterior surfaces of buildings, and the soil around buildings.
Because of the unique ability of insect eggs and other pest lain eggs to resist
nt action, as is true of many insecticides and acaricides, repeated applications may be
desirable to control newly emerged larvae.
Additionally, the present invention relates to the use of oil-in-water emulsions
comprising agriculturally active compounds which are herbicides. The term ide is used
herein to mean an active ient that kills, controls or otherwise adversely modifies the
growth of at least one type of plant. An herbicidally ive or vegetation controlling
amount of an herbicide is an amount of active ingredient which causes an adversely
modifying effect and includes deviations from natural pment of the plant, killing,
tion, desiccation, retardation, and the like. The terms “plants” and “vegetation” include
emerging ngs as well as established and t vegetation.
Herbicidal activity may be exhibited when the compound(s) are applied
directly to the locus of an undesirable plant thereof at any stage of growth or before
emergence of the weeds. The effect observed depends upon factors such as the plant s
to be controlled, the stage of growth of the plant, the particle size of solid components, the
environmental conditions at the time of use, the specific adjuvants and carriers employed, the
soil type, and the like, as well as the amount of chemical applied. These and other s can
be adjusted, as is known in the art, to promote selective herbicidal action. Generally, it is
preferred to apply such herbicides post emergence or to vely immature undesirable
vegetation to achieve the maximum control of weeds.
Still other s of the present invention e methods of preventing or
controlling pests such as nematodes, mites, arthropods, rodents, termites, bacteria or other
microorganisms, comprising applying to a locus where control or prevention is desired a
composition of the present invention which comprises the appropriate active compound such
as a nematocide, miticide, arthropodicide, rodenticide, termiticide or biocide.
The actual amount of agriculturally active compound to be applied to loci of
disease, insects and mites, weeds or other pests is well known in the art and can y be
determined by those skilled in the art in view of the teachings above.
The composition of the present ion surprisingly offers stable agricultural
-water emulsions having low viscosity and long term shelf life. Additionally, the stable
agricultural oil-in-water emulsions of the present invention can offer other surprising
improvements, e. g., efflcacy.
The following examples are provided to illustrate the present invention. The
examples are not intended to limit the scope of the present invention and they should not be
so interpreted. Amounts are in weight parts or weight percentages unless otherwise
indicated.
The following examples are provided to further illustrate the ion and are
not meant to be construed as limiting.
As disclosed herein, all temperatures are given in degrees Celsius and all
tages are weight percentages unless otherwise stated.
In the specific es disclosed herein, the exemplary emulsions are created
ing to the following procedure:
Oil phase A and the aqueous phase B may be heated separately to their desired
temperatures. Phase B is poured into Phase A, with ng of 3000 — 7000 rpm provided by
a Silverson L4RT high shear homogenizer fitted with a square hole high shear screen.
Stirring and temperature conditions are maintained for about 5 to about 15 minutes.
The mixture is then introduced into a Niro Soavi high pressure 2—stage
homogenizer of type Panda 2K, which is adjusted to a pressure of about 500 to about 1000
bar for l to 4 successive passages.
A stabilized oil-in-water on is thus obtained, the oily globules of which
have a mean diameter of typically about 200 nm.
The components of Formulation l are summarized in Table l.
Table 1: 35% soybean oil—in—water emulsion.
01'] phase weight percent (wt. %)
Soybean Oil 35
Aqueous phase wt. %
Cedepal 1 0.5
Atlas 2 2.0
Soprophor 796/P3 0.25
Propylene Glycol 6.0
Water (to balance)
Formulation 1 demonstrated excellent physical stability. For example,
Formulation l was stable under accelerated storage test conditions of 8 weeks at about 54°C,
and cycling temperature from about 400C to about -100C with no change in the size of the
oily globules and no sedimentation or syneresis.
The components of ation 2 are summarized in Table 2.
Both ary Formulations 2 and 3, disclosed herein, were developed to
demonstrate that the current invention may be combined with a vegetable oil modified phase
to ss Ostwald Ripening and deliver superior physical stability over storage.
1 Sodium trideceth sulfate, available from Stepan, Northfield, is
2 Polyalkylene glycol ether, available from Croda Uniqema Inc, New Castle, Delaware
3 Ethoproxylated polyaryl phenol, available from Rhodia, Cranberry,
Table 2: 100 ae/l Flurox o r MHE + 100 ae/lTric10o r BEE -water emulsion.
Oilphase wt. %
Triclopyr butoxyethylester (BEE) 13.10
Fluroxypyr methylheptylester (MHE) 13.50
Agnique AMD 8104 4
Soybean Oil 4
Aqueous phase wt. %
Cedepal TD—407 0.5
Toximul 83235 2
Propylene Glycol 10
Water (balanced ingredient)
Formulation 2 was stable under rated storage test conditions of 2 weeks
at about 54°C, and cycling temperature from about 400C to about -100C with no change in
the size of the oily globules and no sedimentation or syneresis.
The components of Formulation 3 are summarized in Table 3.
Table 3: 65 gae/l Picloram ylester + 240 gae/l 2,4—D 2—ethyhexylester emulsion
Oilphase wt%
Picloram isooctylester 9.52
2,4-D 2-ethyhexylester 36.2
Soybean oil 4.0
Aqueous phase wt. %
Amisoft HS—2 1P6 0.5
Toximul 8223 2
Soprophor 796/P 0.5
Proxel GXL7 0.l
(NH4)2HPO4 0.5
Propylene Glycol 6
Water (balanced ingredient)
4 NIN-Dimethyldecanamide, available from Cognis, BASF Corporation, Cincinnati, OH
Polyalkylene oxide block copolymer, available from Stepan, Northfield,
6 um royl-L-glutamate, available from Ajinomoto North America Inc, Fort Lee, NJ
~ 19% l,2-Benzisothia zolinone, available from Arch al, Inc., Atlanta, Georgia
Formulation 3 was stable under accelerated storage test conditions of 2 weeks
at about 54°C, and cycling temperature from about 400C to about -100C with no change in
the size of the oily globules and no sedimentation or syneresis.
The components of Formulation 4 are summarzed in Table 4.
Formulation 4 was designed to demonstrate the current invention has inherent
salt tolerance stability. In this example, a Triclopyr butoxyethylester (BEE) emulsion
t Aminopyralid Triisopropanolamine (TIPA) salt was first prepared. Next, the
Triclopyr BEE emulsion was blended with an Aminopyralid TIPA pre-mixture including
water and Propylene glycol to produce the final formulation.
Table 4: 240 gae/l Triclopyr BEE + 30 gae/l Aminopyralid TIPA salt emulsion.
Oilphase wt%
Triclopyr BEE 44.0
Soybean oil 4
Aqueous phase
Cedepal TD—407 0.5
Toximul 8323 2.0
Soprophor 796/P 0.5
Propylene Glycol 6.0
(NH4)2HPO4 0.5
Water ced ingredient)
The above on was then blended with an Aminopyralid TIPA salt pre—
mixture to create the ation summarized in Table 5.
Table 5: Blended salt tolerant formulation (by weight percent).
pyr BEE 29.44
Propylene Glycol
Water plus ients listed in
Table 4 balanced in redients
The formulation disclosed in Table 5 was stable under accelerated storage test
conditions of 4 weeks at about 54°C, and cycling temperature from about 400C to about —
100C with no change in the size of the oily globules and no sedimentation or syneresis.
The components of Formulation 5 are ized in Table 6.
Formulation 5 was designed in part to demonstrate that the current invention
may be ed with the current oil-in-water technology as well as a polymer modified oil
phase. The resulting formulation was stable during storage. The sample ation process
was similar to that of Formulation 4, described above.
Table 6: 80 gae/l Fluroxypyr MHE + 40 gae/l Aminopyralid K salt Emulsion.
Oilphase wt%
Fluroxypyr MHE 27.29
Agnique AMD 810 20
l 108 2.59
Nikkol DGMs9 2.7
Tween 61 2.03
Aqueous phase
Amisoft HS-2lP 0.53
Propylene Glycol 6.0
Water (balanced ingredient)
Formulation 5 (Table 6) was first mixed with Toximul 8323 and Soprophor
796/P for l-2 hours with good agitation. Then Aminopyralid potassium (K) salt pre-mixture
(Aminopyralid K, Propylene Glycol, and water) was slowly added into the formulation with
good agitation to make the final formulation which is shown in Table 7.
Table 7: Polymer modified oil phase blended ation (by weight percent).
Fluroxypyr MHE l 1.03
Aminopyralid K10 4.53
Toximul 8323 2
Soprophor 796/P 0.5
Propylene Glycol 10
Water plus ients from Table 6
(balance ingredients)
The formulation of Table 7 was stable under accelerated storage test
conditions of 5 weeks at about 54°C, and cycling temperature from about 400C to about —
100C with no change in the size of the oily globules and no sedimentation or syneresis.
8 Ethylecellulose, available from
Dow, Midland, Michigan
9 Polyglyceryl-2
stearate, available from , Tokyo, Japan
dine carboxylic acid, 4 amino-3.6-dichloro, available from
Dow AgroSciences, apolis, Indiana
1001 106808
While the novel technology has been illustrated and described in detail in the
figures and foregoing description, the same is to be considered as illustrative and not
restrictive in character, it being understood that only some of the embodiments have been
shown and described and that all changes and modifications that come within the spirit of the
novel technology are desired to be protected. As well, While the novel technology was
illustrated using specific es, theoretical arguments, accounts, and illustrations, these
illustrations and the accompanying discussion should by no means be interpreted as limiting
the technology. All patents, patent applications, and references to texts, scientific treatises,
publications, and the like nced in this ation are incorporated herein by nce in
their ty.
As used herein, except where the context requires otherwise, the term
II II
"comprise" and ions ofthe term, such as "comprising , comprises" and "comprised",
are not intended to exclude other additives, components, integers or steps.
Reference to any prior art in the specification is not, and should not be taken
this prior art forms part of the
as, an acknowledgment or any form of suggestion that
common general knowledge in New Zealand or any other jurisdiction.
1001187806
Claims (30)
1. An oil-in—water emulsion composition having at least one agriculturally active compound, the oil-in—water emulsion ition comprising: A) an oil phase, wherein the oil phase comprises at least one agriculturally active ingredient, said oil phase comprising oily globules, the oily globules having a mean particle diameter of less than about 800 nanometers; and B) an aqueous phase, wherein the oily globules are dispersed in the aqueous phase and wherein at least some of the oily globules dispersed in the s phase are coated with a polymeric adsorption layer, wherein said polymeric adsorption layer consists of: (l) at least one polymeric surface—active agent having an HLB value in the range of about 16 to about 18; and (2) at least one ionic surface—active agent.
2. The composition of Claim 1 wherein the aqueous phase comprises a second polymeric e active agent having an HLB in the range of about 12 to about 14.
3. The composition of Claim 1 or 2 wherein the polymeric surface—active agent is selected from the group consisting of: amphipathic block and graft copolymers.
4. The composition of any one of the preceding claims n the ionic surface— active agent is selected from the group consisting of: (a) neutralized anionic surface—active derivatives and (d) cationic agents, (b) amphoteric surface—active agents, (c) alkylsulphonic surface—active agents.
5. The composition of Claim 4, n the ionic surface—active agent is selected from the group consisting of: alkali metal salts of dicetyl phosphate and dimyristyl phosphate; alkali metal salts of cholesteryl sulphate and teryl ate; lipoamino acids and their salts; phospholipids; the mono- and disodium salts of acylglutamic acids; and alkyl ether citrates.
6. The composition of Claim 5, n the alkali metal salts of l phosphate and dimyristyl phosphate are sodium or potassium salts.
7. The composition of Claim 5, wherein the alkali metal salt of cholesteryl sulphate and cholesteryl phosphate is a sodium salt.
8. The composition of Claim 5, wherein the lipoamino acids and their salts are selected from mono— and di—sodium acylglutamates. 1001 187806
9. The composition of Claim 8, wherein the disodium acylglutamate is the disodium salt of N-stearoyl-L—glutamie acid.
10. The composition of Claim 5, wherein the um salt of aeylglutarnic acid is the disodium salt of N—stearoyl glutamic acid.
11. The composition of Claim 5, wherein the ionic surface-active agent is a phospholipid.
12. The composition of Claim 4 wherein the ionic surface-active agent is an alkylsulphonic derivative.
13. The composition of Claim 4 wherein the ionic surface—active agent is selected from the group consisting of quaternary um salts, fatty amines and salts thereof.
14. The ition of any one of the preceding claims, wherein the amount of the polymeric surface—active agents (1) in the composition is in the range of about 30 to about 95 wt. % ofthe total of both (1) and (2).
l5. The composition ofClaim 14, wherein the amount of the polymeric surface— total active agents (1) in the composition is in the range of about 50 to about 95 wt. % of the of both (1) and (2).
16. The composition of any one of the preceding claims, n the amount of about 50 wt. the ionic e active agent (2) in the composition is in the range of about 5 to % of the total combined weight of (1) and (2).
17. The composition of Claim 16, wherein the amount of the ionic surface active 50 wt. % of the total agent (2) in the composition is in the range of about 10 to about combined weight of(l) and (2).
18. The composition of any one of the preceding claims, wherein the coating on total the oily globules comprises between about 0.5 wt. % to about 20 wt. % based on the weight of the oil—in—water on.
19. The ition of Claim 18, wherein the coating on the oily globules comprises between about 0.5 wt. °/o to about 10 Wt. % based on the total weight of the oil—in- water emulsion.
20. The ition of Claim 19, wherein the coating on the oily globules comprises between about 0.5 wt. % to about 2.5 wt. % based on the total weight of the oil-in— water emulsion.
21. The composition of any one of the preceding claims, wherein the oil—in-water emulsion ses at least one agriculturally active ingredient selected from the group 1001 187806 consisting of: fungicides, insecticides, nematocides, miticides, biocides, termiticides, rodenticides, arthropodicides, herbicides, bactericides, and bacteria stats.
22. The composition of Claim 21 , wherein the active ingredient is an ide selected from the group consisting of 2,4-D, aminopyralid, clopyralid, cyhalofop, fluroxypyr, haloxyfop, haloxyfop-P, picloram and triclopyr.
23. The composition of Claim 21, wherein the active ingredient is an insecticide ed from the group consisting of bifenthrin, chlorpyrifos, chlorpyrifos-methyl, rin, beta—cyfluthrin, cyhalothrin, gamma—cyhalothrin, lambda—cyhalothrin, cypermethrin, alpha- cypermethrin, ypermethrin, fenvalerate and permethrin
24. The composition of Claim 21, wherein the active ingredient is a fungicide selected from the group consisting of dinocap, fenbuconazole, meptyl dinocap, myclobutanil and onazole.
25. A method of treating a plant, comprising the steps of: providing an oil—in—water composition according to any one of the preceding claims.
26. A method of treating a plant, comprising the steps of: ng the oil—in—water composition of any one of the preceding claims to a surface.
27. The method according to Claim 26, wherein the surface is the surface of a plant.
28. The method according to Claim 26, n the surface is adjacent to a plant.
29. The method according to Claim 26, wherein the surface is a surface ofa plant pest or a plant pathogen.
30. The ition of Claim 1, substantially as herein described.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161432878P | 2011-01-14 | 2011-01-14 | |
US61/432,878 | 2011-01-14 | ||
PCT/US2012/021075 WO2012097149A1 (en) | 2011-01-14 | 2012-01-12 | Agricultural compositions comprising oil-in-water emulsions |
Publications (2)
Publication Number | Publication Date |
---|---|
NZ612894A NZ612894A (en) | 2015-09-25 |
NZ612894B2 true NZ612894B2 (en) | 2016-01-06 |
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