NZ604558A - Deuterated benzylbenzene derivatives and methods of use - Google Patents

Deuterated benzylbenzene derivatives and methods of use

Info

Publication number
NZ604558A
NZ604558A NZ604558A NZ60455809A NZ604558A NZ 604558 A NZ604558 A NZ 604558A NZ 604558 A NZ604558 A NZ 604558A NZ 60455809 A NZ60455809 A NZ 60455809A NZ 604558 A NZ604558 A NZ 604558A
Authority
NZ
New Zealand
Prior art keywords
compounds
methods
triol
pyran
tetrahydro
Prior art date
Application number
NZ604558A
Inventor
Min Xu
Yan Feng
Brian Seed
Lili Zhang
Xinxing Tang
Jiyan Du
Kun Peng
Ge Xu
Yuanwei Chen
Jacques Y Roberge
Jiajia Dong
Baihua Xu
Binhua Lv
Original Assignee
Theracos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theracos Inc filed Critical Theracos Inc
Publication of NZ604558A publication Critical patent/NZ604558A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

604558 Disclosed are deuterated compounds of formula (I) having an inhibitory effect on sodium-dependent glucose co-transporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition. Examples of compounds of formula (I) include deuterium substituted versions of: (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol and (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-(2,2-difluoroethoxy)ethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol.
NZ604558A 2008-07-15 2009-07-15 Deuterated benzylbenzene derivatives and methods of use NZ604558A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13496808P 2008-07-15 2008-07-15
NZ59110909 2009-07-15

Publications (1)

Publication Number Publication Date
NZ604558A true NZ604558A (en) 2014-05-30

Family

ID=58408257

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ604558A NZ604558A (en) 2008-07-15 2009-07-15 Deuterated benzylbenzene derivatives and methods of use

Country Status (1)

Country Link
NZ (1) NZ604558A (en)

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