NZ601969A - Taste-masked multiparticulate pharmaceutical compositions comprising a drug-containing core particle and a solvent-coacervated membrane - Google Patents
Taste-masked multiparticulate pharmaceutical compositions comprising a drug-containing core particle and a solvent-coacervated membraneInfo
- Publication number
- NZ601969A NZ601969A NZ601969A NZ60196905A NZ601969A NZ 601969 A NZ601969 A NZ 601969A NZ 601969 A NZ601969 A NZ 601969A NZ 60196905 A NZ60196905 A NZ 60196905A NZ 601969 A NZ601969 A NZ 601969A
- Authority
- NZ
- New Zealand
- Prior art keywords
- composition
- taste
- calcium
- drug
- membrane
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
ABSTRACT - 601969 The disclosure relates to a taste-masked multiparticulate pharmaceutical composition comprising: (a) a drug-containing core particle, and (b) a solvent-coacervated membrane on said drug-containing core particle comprising a combination of a water-insoluble polymer and a gastrosoluble, organic or inorganic pore-former at a ratio ranging from about 95/5 to about 50/050, said membrane having a thickness of from about 5% to about 50% by weight based on the weight of the coated particle and an average particle size of not more than about 400μm, wherein said composition has the following properties: (1) said composition has acceptable taste-masking when the composition is placed in the oral cavity for at least about 60 seconds; and (2) said composition releases not less than about 60% of the dose in 30 min when tested for dissolution using United States Pharmacopoeia Apparatus ! (Baskets @ 100 rpm in 900 mL of pH 1.2 buffer), and wherein said water insoluble polymer is selected from the group consisting of ethylcellulose, cellulose acetate, cellulose acetate butyrate, polyvinyl acetate, neutral methacrylic ester copolymer, ammonio-methacrylate copolymers and mixtures thereof, and said gastrosoluble organic or inorganic pore-former is selected from the group consisting of calcium carbonate, calcium phosphate, calcium saccharide, calcium succinate, calcium tartrate, ferric acetate, ferric hydroxide, ferric phosphate, magnesium carbonate, magnesium citrate, magnesium hydroxide, magnesium phosphate, and mixtures thereof. Also disclosed is a method of manufacturing the taste-masked multi-particulate composition comprising the above features.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62752504P | 2004-11-12 | 2004-11-12 | |
| US11/213,266 US20060105038A1 (en) | 2004-11-12 | 2005-08-26 | Taste-masked pharmaceutical compositions prepared by coacervation |
| NZ58910905 | 2005-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ601969A true NZ601969A (en) | 2014-03-28 |
Family
ID=50542736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ601969A NZ601969A (en) | 2004-11-12 | 2005-10-13 | Taste-masked multiparticulate pharmaceutical compositions comprising a drug-containing core particle and a solvent-coacervated membrane |
Country Status (1)
| Country | Link |
|---|---|
| NZ (1) | NZ601969A (en) |
-
2005
- 2005-10-13 NZ NZ601969A patent/NZ601969A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ERR | Error or correction |
Free format text: THE MISSING INVENTOR HAS BEEN ADDED (1355696, LAI, JIN-WANG; 1355697, QIAN, KEN; 1355698, VENKATESH, GOPI) Effective date: 20140217 |
|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 6 YEARS UNTIL 13 OCT 2015 BY AJ PARK Effective date: 20141002 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 13 OCT 2016 BY COMPUTER PACKAGES INC Effective date: 20150918 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 13 OCT 2017 BY COMPUTER PACKAGES INC Effective date: 20160920 |
|
| LAPS | Patent lapsed |