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Application filed by Decode Genetics EhffiledCriticalDecode Genetics Ehf
Publication of NZ601363ApublicationCriticalpatent/NZ601363A/en
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
601363 Disclosed are biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula (I). Examples of compounds of the invention are: 3-Amino-5-(3’-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-phenol; [4-(3’-Acetyl-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-phenyl]-methyl-amine hydrochloride and 4-(3’-Acetyl-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-benzenesulfinic acid amide.
NZ601363A2007-11-212008-11-20Biaryl pde4 inhibitors for treating inflammation
NZ601363A
(en)
4- (1-benzofuran-3-yl-methylideneaminooxy-propoxy) -benzoic acid derivatives and related compounds as PAI-1 inhibitors for the treatment of disorders of fibrinolytic systems, thrombosis