NZ584459A - Cytomegalovirus vaccines and methods of production - Google Patents
Cytomegalovirus vaccines and methods of productionInfo
- Publication number
- NZ584459A NZ584459A NZ584459A NZ58445908A NZ584459A NZ 584459 A NZ584459 A NZ 584459A NZ 584459 A NZ584459 A NZ 584459A NZ 58445908 A NZ58445908 A NZ 58445908A NZ 584459 A NZ584459 A NZ 584459A
- Authority
- NZ
- New Zealand
- Prior art keywords
- cmv
- cells
- vaccine
- cell type
- cell
- Prior art date
Links
- 241000701022 Cytomegalovirus Species 0.000 title claims abstract description 184
- 229960005486 vaccine Drugs 0.000 title claims abstract description 90
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims description 52
- 210000004027 cell Anatomy 0.000 claims abstract description 240
- 210000004748 cultured cell Anatomy 0.000 claims abstract description 13
- 241000700605 Viruses Species 0.000 claims description 113
- 210000002919 epithelial cell Anatomy 0.000 claims description 73
- 108090000623 proteins and genes Proteins 0.000 claims description 59
- 210000002950 fibroblast Anatomy 0.000 claims description 58
- 208000015181 infectious disease Diseases 0.000 claims description 50
- 210000002845 virion Anatomy 0.000 claims description 49
- 239000000203 mixture Substances 0.000 claims description 43
- 230000004927 fusion Effects 0.000 claims description 41
- 210000000170 cell membrane Anatomy 0.000 claims description 21
- 230000014509 gene expression Effects 0.000 claims description 18
- 238000004113 cell culture Methods 0.000 claims description 17
- 230000008859 change Effects 0.000 claims description 17
- 230000002238 attenuated effect Effects 0.000 claims description 16
- 210000002889 endothelial cell Anatomy 0.000 claims description 13
- 230000004044 response Effects 0.000 claims description 9
- 230000036755 cellular response Effects 0.000 claims description 8
- 230000012010 growth Effects 0.000 claims description 6
- 230000007910 cell fusion Effects 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 5
- 230000003053 immunization Effects 0.000 claims description 5
- 230000001404 mediated effect Effects 0.000 claims description 5
- 210000004443 dendritic cell Anatomy 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 210000002540 macrophage Anatomy 0.000 claims description 4
- 210000002569 neuron Anatomy 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims description 3
- 210000002536 stromal cell Anatomy 0.000 claims description 3
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 29
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 27
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 description 24
- 230000000694 effects Effects 0.000 description 23
- 108090000765 processed proteins & peptides Proteins 0.000 description 21
- 102000004169 proteins and genes Human genes 0.000 description 20
- 239000002245 particle Substances 0.000 description 18
- 102100028162 ATP-binding cassette sub-family C member 3 Human genes 0.000 description 16
- 101000986633 Homo sapiens ATP-binding cassette sub-family C member 3 Proteins 0.000 description 16
- 102100021662 Baculoviral IAP repeat-containing protein 3 Human genes 0.000 description 15
- 206010011831 Cytomegalovirus infection Diseases 0.000 description 15
- 101000846416 Homo sapiens Fibroblast growth factor 1 Proteins 0.000 description 15
- 102000004196 processed proteins & peptides Human genes 0.000 description 15
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 13
- 125000003729 nucleotide group Chemical group 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 13
- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 12
- 101001005722 Homo sapiens Melanoma-associated antigen 6 Proteins 0.000 description 12
- 102100025075 Melanoma-associated antigen 6 Human genes 0.000 description 12
- 102100028960 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Human genes 0.000 description 12
- 239000000463 material Substances 0.000 description 12
- 102100034221 Growth-regulated alpha protein Human genes 0.000 description 11
- 101000896224 Homo sapiens Baculoviral IAP repeat-containing protein 3 Proteins 0.000 description 11
- 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 description 11
- 102100035019 Peptide chain release factor 1, mitochondrial Human genes 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 230000012202 endocytosis Effects 0.000 description 11
- 230000000644 propagated effect Effects 0.000 description 11
- 102100022108 Aspartyl/asparaginyl beta-hydroxylase Human genes 0.000 description 10
- 101000901030 Homo sapiens Aspartyl/asparaginyl beta-hydroxylase Proteins 0.000 description 10
- 101000591236 Homo sapiens Receptor-type tyrosine-protein phosphatase R Proteins 0.000 description 10
- 102100034101 Receptor-type tyrosine-protein phosphatase R Human genes 0.000 description 10
- 108020004999 messenger RNA Proteins 0.000 description 10
- 239000002773 nucleotide Substances 0.000 description 10
- 102100025674 Angiopoietin-related protein 4 Human genes 0.000 description 9
- 102100040352 Heat shock 70 kDa protein 1A Human genes 0.000 description 9
- 101000752249 Homo sapiens Rho guanine nucleotide exchange factor 3 Proteins 0.000 description 9
- 101710110377 Immediate early protein IE1 Proteins 0.000 description 9
- 101710205424 Immediate-early protein 1 Proteins 0.000 description 9
- 102100023171 Nuclear receptor subfamily 1 group D member 2 Human genes 0.000 description 9
- 102100040375 Peripherin-2 Human genes 0.000 description 9
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 description 9
- 102100021689 Rho guanine nucleotide exchange factor 3 Human genes 0.000 description 9
- 239000012528 membrane Substances 0.000 description 9
- 150000007523 nucleic acids Chemical class 0.000 description 9
- 238000011282 treatment Methods 0.000 description 9
- 102100022464 5'-nucleotidase Human genes 0.000 description 8
- 102100036571 Coiled-coil domain-containing protein 171 Human genes 0.000 description 8
- 102100033069 Histone acetyltransferase KAT8 Human genes 0.000 description 8
- 101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 description 8
- 101000715241 Homo sapiens Coiled-coil domain-containing protein 171 Proteins 0.000 description 8
- 101000944170 Homo sapiens Histone acetyltransferase KAT8 Proteins 0.000 description 8
- 101000610652 Homo sapiens Peripherin-2 Proteins 0.000 description 8
- 101000804728 Homo sapiens Protein Wnt-2b Proteins 0.000 description 8
- 102100037920 Insulin-like growth factor 2 mRNA-binding protein 3 Human genes 0.000 description 8
- 102100029607 Interferon-induced protein 44 Human genes 0.000 description 8
- 102100035289 Protein Wnt-2b Human genes 0.000 description 8
- 102100036900 Radiation-inducible immediate-early gene IEX-1 Human genes 0.000 description 8
- 210000004436 artificial bacterial chromosome Anatomy 0.000 description 8
- XDHNQDDQEHDUTM-UHFFFAOYSA-N bafliomycin A1 Natural products COC1C=CC=C(C)CC(C)C(O)C(C)C=C(C)C=C(OC)C(=O)OC1C(C)C(O)C(C)C1(O)OC(C(C)C)C(C)C(O)C1 XDHNQDDQEHDUTM-UHFFFAOYSA-N 0.000 description 8
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 210000001163 endosome Anatomy 0.000 description 8
- 239000002609 medium Substances 0.000 description 8
- 239000002953 phosphate buffered saline Substances 0.000 description 8
- 229920001184 polypeptide Polymers 0.000 description 8
- 102100029516 Basic salivary proline-rich protein 1 Human genes 0.000 description 7
- 102100035746 DET1- and DDB1-associated protein 1 Human genes 0.000 description 7
- 102100039632 Glioma pathogenesis-related protein 1 Human genes 0.000 description 7
- 101001125486 Homo sapiens Basic salivary proline-rich protein 1 Proteins 0.000 description 7
- 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 description 7
- 101001090948 Homo sapiens Peptide chain release factor 1, mitochondrial Proteins 0.000 description 7
- 101000637031 Homo sapiens Trafficking protein particle complex subunit 9 Proteins 0.000 description 7
- 102100032999 Integrin beta-3 Human genes 0.000 description 7
- 108091008770 Rev-ErbAß Proteins 0.000 description 7
- 102100031926 Trafficking protein particle complex subunit 9 Human genes 0.000 description 7
- 102100038102 Whirlin Human genes 0.000 description 7
- 238000003556 assay Methods 0.000 description 7
- XDHNQDDQEHDUTM-JQWOJBOSSA-N bafilomycin A1 Chemical compound CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@]1(O)O[C@H](C(C)C)[C@@H](C)[C@H](O)C1 XDHNQDDQEHDUTM-JQWOJBOSSA-N 0.000 description 7
- XDHNQDDQEHDUTM-ZGOPVUMHSA-N bafilomycin A1 Natural products CO[C@H]1C=CC=C(C)C[C@H](C)[C@H](O)[C@H](C)C=C(C)C=C(OC)C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@]1(O)O[C@H](C(C)C)[C@@H](C)[C@H](O)C1 XDHNQDDQEHDUTM-ZGOPVUMHSA-N 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 238000011161 development Methods 0.000 description 7
- 230000002163 immunogen Effects 0.000 description 7
- 238000002493 microarray Methods 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 230000002103 transcriptional effect Effects 0.000 description 7
- 102100031168 CCN family member 2 Human genes 0.000 description 6
- 102100040836 Claudin-1 Human genes 0.000 description 6
- 102100027778 GTP-binding protein Rit2 Human genes 0.000 description 6
- 102100040407 Heat shock 70 kDa protein 1B Human genes 0.000 description 6
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 description 6
- 101001015004 Homo sapiens Integrin beta-3 Proteins 0.000 description 6
- 101001123296 Homo sapiens PR domain zinc finger protein 15 Proteins 0.000 description 6
- 101001123331 Homo sapiens Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Proteins 0.000 description 6
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 description 6
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 6
- 102100028975 PR domain zinc finger protein 15 Human genes 0.000 description 6
- 102100027351 Pentraxin-related protein PTX3 Human genes 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- 230000003321 amplification Effects 0.000 description 6
- 210000003719 b-lymphocyte Anatomy 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 210000000234 capsid Anatomy 0.000 description 6
- 230000001413 cellular effect Effects 0.000 description 6
- 230000001143 conditioned effect Effects 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 238000003199 nucleic acid amplification method Methods 0.000 description 6
- 230000037361 pathway Effects 0.000 description 6
- 230000001902 propagating effect Effects 0.000 description 6
- 230000002207 retinal effect Effects 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000002255 vaccination Methods 0.000 description 6
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 6
- 102100025261 AMSH-like protease Human genes 0.000 description 5
- 102100026789 Aryl hydrocarbon receptor repressor Human genes 0.000 description 5
- 102100035793 CD83 antigen Human genes 0.000 description 5
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 description 5
- 108010027814 HSP72 Heat-Shock Proteins Proteins 0.000 description 5
- 101000693076 Homo sapiens Angiopoietin-related protein 4 Proteins 0.000 description 5
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 description 5
- 101100392605 Homo sapiens GLIPR1 gene Proteins 0.000 description 5
- 101001037759 Homo sapiens Heat shock 70 kDa protein 1A Proteins 0.000 description 5
- 101001086163 Homo sapiens Olfactory receptor 7C2 Proteins 0.000 description 5
- 101000999079 Homo sapiens Radiation-inducible immediate-early gene IEX-1 Proteins 0.000 description 5
- 101000606090 Homo sapiens Tyrosinase Proteins 0.000 description 5
- 101000666127 Homo sapiens Whirlin Proteins 0.000 description 5
- 102100040066 Interleukin-27 receptor subunit alpha Human genes 0.000 description 5
- 108060001084 Luciferase Proteins 0.000 description 5
- -1 NM_00685I) Proteins 0.000 description 5
- 102100031448 Olfactory receptor 7C2 Human genes 0.000 description 5
- 102100024060 Type II iodothyronine deiodinase Human genes 0.000 description 5
- 102100039094 Tyrosinase Human genes 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 5
- 210000000805 cytoplasm Anatomy 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000020477 pH reduction Effects 0.000 description 5
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 description 5
- 210000001127 pigmented epithelial cell Anatomy 0.000 description 5
- 102000040430 polynucleotide Human genes 0.000 description 5
- 108091033319 polynucleotide Proteins 0.000 description 5
- 239000002157 polynucleotide Substances 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 241001529453 unidentified herpesvirus Species 0.000 description 5
- 102100040924 60S ribosomal protein L6 Human genes 0.000 description 4
- 102100026396 ADP/ATP translocase 2 Human genes 0.000 description 4
- 102100040023 Adhesion G-protein coupled receptor G6 Human genes 0.000 description 4
- 101100120045 Bos taurus FGF1 gene Proteins 0.000 description 4
- 102100024782 Centrosomal protein POC5 Human genes 0.000 description 4
- 101710181333 Chaperone protein dnaK1 Proteins 0.000 description 4
- 108091026890 Coding region Proteins 0.000 description 4
- 108091033380 Coding strand Proteins 0.000 description 4
- 102000012688 DDA1 Human genes 0.000 description 4
- 102100028073 Fibroblast growth factor 5 Human genes 0.000 description 4
- 102000003886 Glycoproteins Human genes 0.000 description 4
- 108090000288 Glycoproteins Proteins 0.000 description 4
- 102100040408 Heat shock 70 kDa protein 1-like Human genes 0.000 description 4
- 101100378639 Homo sapiens ADGRG6 gene Proteins 0.000 description 4
- 101000690533 Homo sapiens Aryl hydrocarbon receptor repressor Proteins 0.000 description 4
- 101000687829 Homo sapiens Centrosomal protein POC5 Proteins 0.000 description 4
- 101000749331 Homo sapiens Claudin-1 Proteins 0.000 description 4
- 101001033007 Homo sapiens Granzyme K Proteins 0.000 description 4
- 101001037977 Homo sapiens Heat shock 70 kDa protein 1-like Proteins 0.000 description 4
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 description 4
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 4
- 101000869426 Homo sapiens Metal cation symporter ZIP14 Proteins 0.000 description 4
- 101001016777 Homo sapiens Microtubule-associated protein 9 Proteins 0.000 description 4
- 101001082142 Homo sapiens Pentraxin-related protein PTX3 Proteins 0.000 description 4
- 101000595513 Homo sapiens Phosphatidylinositol 4-phosphate 5-kinase type-1 beta Proteins 0.000 description 4
- 101001037087 Homo sapiens Putative golgin subfamily A member 2B Proteins 0.000 description 4
- 101001075453 Homo sapiens Regulator of G-protein signaling 17 Proteins 0.000 description 4
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 4
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 description 4
- 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 description 4
- 102100038235 Large neutral amino acids transporter small subunit 2 Human genes 0.000 description 4
- 102100023261 MAGUK p55 subfamily member 4 Human genes 0.000 description 4
- 102100032280 Metal cation symporter ZIP14 Human genes 0.000 description 4
- 102100032485 Microtubule-associated protein 9 Human genes 0.000 description 4
- 101100378640 Mus musculus Adgrg6 gene Proteins 0.000 description 4
- 101001122350 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Proteins 0.000 description 4
- 102100036081 Phosphatidylinositol 4-phosphate 5-kinase type-1 beta Human genes 0.000 description 4
- 102100025073 Potassium voltage-gated channel subfamily H member 8 Human genes 0.000 description 4
- 102100040189 Putative golgin subfamily A member 2B Human genes 0.000 description 4
- 102100020982 Regulator of G-protein signaling 17 Human genes 0.000 description 4
- 102100022092 Ribosomal oxygenase 2 Human genes 0.000 description 4
- 108091006715 SLC25A5 Proteins 0.000 description 4
- 102100023536 Solute carrier family 2, facilitated glucose transporter member 1 Human genes 0.000 description 4
- 102100022004 Solute carrier organic anion transporter family member 4A1 Human genes 0.000 description 4
- 208000036920 Stüve-Wiedemann syndrome 1 Diseases 0.000 description 4
- 102100026707 Sulfotransferase 4A1 Human genes 0.000 description 4
- 102100034769 Thioredoxin-dependent peroxide reductase, mitochondrial Human genes 0.000 description 4
- 102100034392 Trypsin-2 Human genes 0.000 description 4
- 208000025531 adult-onset foveomacular vitelliform dystrophy Diseases 0.000 description 4
- 230000005754 cellular signaling Effects 0.000 description 4
- 101150044395 dda1 gene Proteins 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 230000003511 endothelial effect Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 238000013518 transcription Methods 0.000 description 4
- 230000035897 transcription Effects 0.000 description 4
- 239000003981 vehicle Substances 0.000 description 4
- 102100027518 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Human genes 0.000 description 3
- 102100032383 Adherens junction-associated protein 1 Human genes 0.000 description 3
- 101000575029 Bacillus subtilis (strain 168) 50S ribosomal protein L11 Proteins 0.000 description 3
- 102100035350 CUB domain-containing protein 1 Human genes 0.000 description 3
- 102100031192 Chondroitin sulfate N-acetylgalactosaminyltransferase 1 Human genes 0.000 description 3
- 102100031049 Coiled-coil domain-containing protein 7 Human genes 0.000 description 3
- 102100031476 Cytochrome P450 1A1 Human genes 0.000 description 3
- 102100029012 Dysbindin Human genes 0.000 description 3
- 101710170470 Glycoprotein 42 Proteins 0.000 description 3
- 102100040517 Golgi-associated kinase 1B Human genes 0.000 description 3
- 101000861278 Homo sapiens 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Proteins 0.000 description 3
- 101000648020 Homo sapiens AMSH-like protease Proteins 0.000 description 3
- 101000797959 Homo sapiens Adherens junction-associated protein 1 Proteins 0.000 description 3
- 101000942590 Homo sapiens CCR4-NOT transcription complex subunit 9 Proteins 0.000 description 3
- 101000776615 Homo sapiens Chondroitin sulfate N-acetylgalactosaminyltransferase 1 Proteins 0.000 description 3
- 101000777368 Homo sapiens Coiled-coil domain-containing protein 7 Proteins 0.000 description 3
- 101000941690 Homo sapiens Cytochrome P450 1A1 Proteins 0.000 description 3
- 101100223407 Homo sapiens DDA1 gene Proteins 0.000 description 3
- 101000838672 Homo sapiens Dysbindin Proteins 0.000 description 3
- 101001011663 Homo sapiens Mixed lineage kinase domain-like protein Proteins 0.000 description 3
- 101000576323 Homo sapiens Motor neuron and pancreas homeobox protein 1 Proteins 0.000 description 3
- 101100409188 Homo sapiens PPARGC1A gene Proteins 0.000 description 3
- 101001098545 Homo sapiens Polyadenylate-binding protein 1-like Proteins 0.000 description 3
- 101001026214 Homo sapiens Potassium voltage-gated channel subfamily A member 5 Proteins 0.000 description 3
- 101000712982 Homo sapiens Ras association domain-containing protein 8 Proteins 0.000 description 3
- 101001090050 Homo sapiens Thioredoxin-dependent peroxide reductase, mitochondrial Proteins 0.000 description 3
- 101000610602 Homo sapiens Tumor necrosis factor receptor superfamily member 10C Proteins 0.000 description 3
- 101001053754 Homo sapiens Type II iodothyronine deiodinase Proteins 0.000 description 3
- 101000823271 Homo sapiens Tyrosine-protein kinase ABL2 Proteins 0.000 description 3
- 101000785610 Homo sapiens Zinc finger protein 658 Proteins 0.000 description 3
- 101000723956 Homo sapiens Zinc finger protein with KRAB and SCAN domains 7 Proteins 0.000 description 3
- 102100027355 Interferon-induced protein with tetratricopeptide repeats 1 Human genes 0.000 description 3
- 239000005089 Luciferase Substances 0.000 description 3
- 102100030177 Mixed lineage kinase domain-like protein Human genes 0.000 description 3
- 102100025170 Motor neuron and pancreas homeobox protein 1 Human genes 0.000 description 3
- 241000282577 Pan troglodytes Species 0.000 description 3
- 102100037138 Polyadenylate-binding protein 1-like Human genes 0.000 description 3
- 102100037445 Potassium voltage-gated channel subfamily A member 5 Human genes 0.000 description 3
- 102100033218 Ras association domain-containing protein 8 Human genes 0.000 description 3
- 102100033929 Sodium-dependent noradrenaline transporter Human genes 0.000 description 3
- 108020004566 Transfer RNA Proteins 0.000 description 3
- 102100026893 Troponin T, cardiac muscle Human genes 0.000 description 3
- 102100040115 Tumor necrosis factor receptor superfamily member 10C Human genes 0.000 description 3
- 102100022651 Tyrosine-protein kinase ABL2 Human genes 0.000 description 3
- 101710135389 Unconventional myosin-Ia Proteins 0.000 description 3
- 102100026495 Zinc finger protein 658 Human genes 0.000 description 3
- 102100028347 Zinc finger protein with KRAB and SCAN domains 7 Human genes 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 125000000539 amino acid group Chemical group 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 238000010367 cloning Methods 0.000 description 3
- 239000002299 complementary DNA Substances 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000004520 electroporation Methods 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 230000002458 infectious effect Effects 0.000 description 3
- 238000003468 luciferase reporter gene assay Methods 0.000 description 3
- 210000004940 nucleus Anatomy 0.000 description 3
- 230000007918 pathogenicity Effects 0.000 description 3
- 108010060054 peroxisome-proliferator-activated receptor-gamma coactivator-1 Proteins 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- PUIBPGHAXSCVRF-QHFGJBOXSA-N prostaglandin C1 Chemical compound CCCCC[C@H](O)\C=C\C1=CCC(=O)[C@@H]1CCCCCCC(O)=O PUIBPGHAXSCVRF-QHFGJBOXSA-N 0.000 description 3
- 238000003753 real-time PCR Methods 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 238000013519 translation Methods 0.000 description 3
- 230000010415 tropism Effects 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- SDWMVMBAKVYNMX-UHFFFAOYSA-N 11-(4-bromophenyl)-9-piperidin-1-ylnaphtho[2,1-b][1,10]phenanthroline-8-carbonitrile Chemical compound BrC1=CC=C(C=C1)C1=C2C=CC3=NC=4C=5N=CC=CC=5C=CC=4C=C3C2=C(C(=C1)N1CCCCC1)C#N SDWMVMBAKVYNMX-UHFFFAOYSA-N 0.000 description 2
- 102100035389 2'-5'-oligoadenylate synthase 3 Human genes 0.000 description 2
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- 101710195537 AMSH-like protease Proteins 0.000 description 2
- 102100039075 Aldehyde dehydrogenase family 1 member A3 Human genes 0.000 description 2
- 102100034083 Alkaline ceramidase 1 Human genes 0.000 description 2
- 102100025672 Angiopoietin-related protein 2 Human genes 0.000 description 2
- 101710085845 Angiopoietin-related protein 4 Proteins 0.000 description 2
- 102100037435 Antiviral innate immune response receptor RIG-I Human genes 0.000 description 2
- 101500021165 Aplysia californica Myomodulin-A Proteins 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 102100023927 Asparagine synthetase [glutamine-hydrolyzing] Human genes 0.000 description 2
- 102100028232 BTB/POZ domain-containing protein KCTD8 Human genes 0.000 description 2
- 102100023013 Basic leucine zipper transcriptional factor ATF-like 3 Human genes 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 101710155857 C-C motif chemokine 2 Proteins 0.000 description 2
- 102100027306 Carotenoid-cleaving dioxygenase, mitochondrial Human genes 0.000 description 2
- 101150091877 Ccn2 gene Proteins 0.000 description 2
- 102100025828 Centromere protein C Human genes 0.000 description 2
- 201000008990 Charcot-Marie-Tooth disease type 2A1 Diseases 0.000 description 2
- 102100035396 Cingulin-like protein 1 Human genes 0.000 description 2
- 101710094648 Coat protein Proteins 0.000 description 2
- 108010039419 Connective Tissue Growth Factor Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 102100027043 Discoidin, CUB and LCCL domain-containing protein 2 Human genes 0.000 description 2
- 102100027274 Dual specificity protein phosphatase 6 Human genes 0.000 description 2
- 102100034568 E3 ubiquitin-protein ligase PDZRN3 Human genes 0.000 description 2
- 108700041152 Endoplasmic Reticulum Chaperone BiP Proteins 0.000 description 2
- 102100021451 Endoplasmic reticulum chaperone BiP Human genes 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 102100029327 FERM domain-containing protein 4A Human genes 0.000 description 2
- 102100034543 Fatty acid desaturase 3 Human genes 0.000 description 2
- 102100022366 Fatty acyl-CoA reductase 1 Human genes 0.000 description 2
- 102100035323 Fibroblast growth factor 18 Human genes 0.000 description 2
- 108090000380 Fibroblast growth factor 5 Proteins 0.000 description 2
- 102100027570 Forkhead box protein Q1 Human genes 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 102000017705 GABRE Human genes 0.000 description 2
- 101150096040 GNAO1 gene Proteins 0.000 description 2
- 102100028463 Galactose-3-O-sulfotransferase 3 Human genes 0.000 description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
- 102100025296 Guanine nucleotide-binding protein G(o) subunit alpha Human genes 0.000 description 2
- 102100035688 Guanylate-binding protein 1 Human genes 0.000 description 2
- 101150112743 HSPA5 gene Proteins 0.000 description 2
- 102100028999 High mobility group protein HMGI-C Human genes 0.000 description 2
- 101000597332 Homo sapiens 2'-5'-oligoadenylate synthase 3 Proteins 0.000 description 2
- 101000673524 Homo sapiens 60S ribosomal protein L6 Proteins 0.000 description 2
- 101100380329 Homo sapiens ASNS gene Proteins 0.000 description 2
- 101000798882 Homo sapiens Actin-like protein 6A Proteins 0.000 description 2
- 101000798834 Homo sapiens Alkaline ceramidase 1 Proteins 0.000 description 2
- 101000693081 Homo sapiens Angiopoietin-related protein 2 Proteins 0.000 description 2
- 101001007225 Homo sapiens BTB/POZ domain-containing protein KCTD8 Proteins 0.000 description 2
- 101000903609 Homo sapiens Basic leucine zipper transcriptional factor ATF-like 3 Proteins 0.000 description 2
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 description 2
- 101100113671 Homo sapiens CLDN1 gene Proteins 0.000 description 2
- 101000737742 Homo sapiens CUB domain-containing protein 1 Proteins 0.000 description 2
- 101000914241 Homo sapiens Centromere protein C Proteins 0.000 description 2
- 101000737619 Homo sapiens Cingulin-like protein 1 Proteins 0.000 description 2
- 101000927579 Homo sapiens D-dopachrome decarboxylase Proteins 0.000 description 2
- 101000911787 Homo sapiens Discoidin, CUB and LCCL domain-containing protein 2 Proteins 0.000 description 2
- 101001131834 Homo sapiens E3 ubiquitin-protein ligase PDZRN3 Proteins 0.000 description 2
- 101001062454 Homo sapiens FERM domain-containing protein 4A Proteins 0.000 description 2
- 101000848246 Homo sapiens Fatty acid desaturase 3 Proteins 0.000 description 2
- 101000824458 Homo sapiens Fatty acyl-CoA reductase 1 Proteins 0.000 description 2
- 101001060267 Homo sapiens Fibroblast growth factor 5 Proteins 0.000 description 2
- 101000861406 Homo sapiens Forkhead box protein Q1 Proteins 0.000 description 2
- 101001073581 Homo sapiens Gamma-aminobutyric acid receptor subunit epsilon Proteins 0.000 description 2
- 101000888759 Homo sapiens Glioma pathogenesis-related protein 1 Proteins 0.000 description 2
- 101000893979 Homo sapiens Golgi-associated kinase 1B Proteins 0.000 description 2
- 101001134268 Homo sapiens Guanine nucleotide exchange factor MSS4 Proteins 0.000 description 2
- 101000857837 Homo sapiens Guanine nucleotide-binding protein G(o) subunit alpha Proteins 0.000 description 2
- 101001001336 Homo sapiens Guanylate-binding protein 1 Proteins 0.000 description 2
- 101000986379 Homo sapiens High mobility group protein HMGI-C Proteins 0.000 description 2
- 101100452137 Homo sapiens IGF2BP3 gene Proteins 0.000 description 2
- 101000599782 Homo sapiens Insulin-like growth factor 2 mRNA-binding protein 3 Proteins 0.000 description 2
- 101000997670 Homo sapiens Integrin beta-8 Proteins 0.000 description 2
- 101001010568 Homo sapiens Interleukin-11 Proteins 0.000 description 2
- 101001003132 Homo sapiens Interleukin-13 receptor subunit alpha-2 Proteins 0.000 description 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 2
- 101001026582 Homo sapiens KAT8 regulatory NSL complex subunit 3 Proteins 0.000 description 2
- 101000605021 Homo sapiens Large neutral amino acids transporter small subunit 2 Proteins 0.000 description 2
- 101000978210 Homo sapiens Leukotriene C4 synthase Proteins 0.000 description 2
- 101001115423 Homo sapiens MAGUK p55 subfamily member 4 Proteins 0.000 description 2
- 101100130490 Homo sapiens MICAL2 gene Proteins 0.000 description 2
- 101100077756 Homo sapiens MPP4 gene Proteins 0.000 description 2
- 101000980162 Homo sapiens Mediator of RNA polymerase II transcription subunit 18 Proteins 0.000 description 2
- 101001018196 Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Proteins 0.000 description 2
- 101000613610 Homo sapiens Monocyte to macrophage differentiation factor Proteins 0.000 description 2
- 101000998194 Homo sapiens NF-kappa-B inhibitor epsilon Proteins 0.000 description 2
- 101000978924 Homo sapiens Nuclear receptor subfamily 1 group D member 2 Proteins 0.000 description 2
- 101000591234 Homo sapiens Phosphatidylinositol phosphatase PTPRQ Proteins 0.000 description 2
- 101000583797 Homo sapiens Protein MCM10 homolog Proteins 0.000 description 2
- 101000962981 Homo sapiens Protein mab-21-like 4 Proteins 0.000 description 2
- 101000891961 Homo sapiens Putative uncharacterized protein encoded by MIR1915-HG Proteins 0.000 description 2
- 101001111714 Homo sapiens RING-box protein 2 Proteins 0.000 description 2
- 101100469010 Homo sapiens RIOX2 gene Proteins 0.000 description 2
- 101000754919 Homo sapiens Ribosomal oxygenase 2 Proteins 0.000 description 2
- 101000879840 Homo sapiens Serglycin Proteins 0.000 description 2
- 101000836079 Homo sapiens Serpin B8 Proteins 0.000 description 2
- 101000702394 Homo sapiens Signal peptide peptidase-like 2A Proteins 0.000 description 2
- 101000639975 Homo sapiens Sodium-dependent noradrenaline transporter Proteins 0.000 description 2
- 101000617818 Homo sapiens Solute carrier organic anion transporter family member 4A1 Proteins 0.000 description 2
- 101000628527 Homo sapiens Sulfotransferase 4A1 Proteins 0.000 description 2
- 101000697347 Homo sapiens Translocon-associated protein subunit gamma Proteins 0.000 description 2
- 101000904724 Homo sapiens Transmembrane glycoprotein NMB Proteins 0.000 description 2
- 101000764260 Homo sapiens Troponin T, cardiac muscle Proteins 0.000 description 2
- 101000960621 Homo sapiens U3 small nucleolar ribonucleoprotein protein IMP3 Proteins 0.000 description 2
- 101100317359 Homo sapiens WHRN gene Proteins 0.000 description 2
- 101000978006 Homo sapiens cAMP-dependent protein kinase inhibitor beta Proteins 0.000 description 2
- 101150014048 IER3 gene Proteins 0.000 description 2
- 101150057152 Igf2bp3 gene Proteins 0.000 description 2
- 206010061598 Immunodeficiency Diseases 0.000 description 2
- 102100033336 Integrin beta-8 Human genes 0.000 description 2
- 102000003815 Interleukin-11 Human genes 0.000 description 2
- 108090000177 Interleukin-11 Proteins 0.000 description 2
- 102100030694 Interleukin-11 Human genes 0.000 description 2
- 101710089672 Interleukin-27 receptor subunit alpha Proteins 0.000 description 2
- 102000015696 Interleukins Human genes 0.000 description 2
- 108010063738 Interleukins Proteins 0.000 description 2
- 102100037489 KAT8 regulatory NSL complex subunit 3 Human genes 0.000 description 2
- 102100023758 Leukotriene C4 synthase Human genes 0.000 description 2
- 241000282560 Macaca mulatta Species 0.000 description 2
- 101710091439 Major capsid protein 1 Proteins 0.000 description 2
- 102100024280 Mediator of RNA polymerase II transcription subunit 18 Human genes 0.000 description 2
- 102000018697 Membrane Proteins Human genes 0.000 description 2
- 108010052285 Membrane Proteins Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 102100033127 Mitogen-activated protein kinase kinase kinase 5 Human genes 0.000 description 2
- 102100040849 Monocyte to macrophage differentiation factor Human genes 0.000 description 2
- 101100396287 Mus musculus Ier3 gene Proteins 0.000 description 2
- 101100181099 Mus musculus Klra1 gene Proteins 0.000 description 2
- 102100033104 NF-kappa-B inhibitor epsilon Human genes 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 108010038807 Oligopeptides Proteins 0.000 description 2
- 102000015636 Oligopeptides Human genes 0.000 description 2
- 102000017946 PGC-1 Human genes 0.000 description 2
- 108700038399 PGC-1 Proteins 0.000 description 2
- 101150009130 Pdgfrl gene Proteins 0.000 description 2
- 101710192097 Pentraxin-related protein PTX3 Proteins 0.000 description 2
- 101710164680 Platelet-derived growth factor receptor beta Proteins 0.000 description 2
- 102100034391 Porphobilinogen deaminase Human genes 0.000 description 2
- 101710163352 Potassium voltage-gated channel subfamily H member 4 Proteins 0.000 description 2
- 241000288906 Primates Species 0.000 description 2
- 102100033344 Programmed cell death 6-interacting protein Human genes 0.000 description 2
- 102100030962 Protein MCM10 homolog Human genes 0.000 description 2
- 102100039626 Protein mab-21-like 4 Human genes 0.000 description 2
- 102100040771 Putative uncharacterized protein encoded by MIR1915-HG Human genes 0.000 description 2
- 101150107549 RUFY3 gene Proteins 0.000 description 2
- 108091007047 SCF complex Proteins 0.000 description 2
- 108091006296 SLC2A1 Proteins 0.000 description 2
- 108091006238 SLC7A8 Proteins 0.000 description 2
- 101100113675 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CLD1 gene Proteins 0.000 description 2
- 101100111629 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) KAR2 gene Proteins 0.000 description 2
- 108050005900 Signal peptide peptidase-like 2a Proteins 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 208000033858 Stüve-Wiedemann syndrome Diseases 0.000 description 2
- 101710083705 Sulfotransferase 4A1 Proteins 0.000 description 2
- 102100028160 Translocon-associated protein subunit gamma Human genes 0.000 description 2
- 102100026228 Transmembrane domain-containing protein TMIGD3 Human genes 0.000 description 2
- 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 description 2
- 101710100962 Type II iodothyronine deiodinase Proteins 0.000 description 2
- 108020005202 Viral DNA Proteins 0.000 description 2
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 2
- 102100024670 Zinc finger protein 45 Human genes 0.000 description 2
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 description 2
- 102100030295 [F-actin]-monooxygenase MICAL2 Human genes 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 108010029777 actin interacting protein 1 Proteins 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 102100023516 cAMP-dependent protein kinase inhibitor beta Human genes 0.000 description 2
- 230000023402 cell communication Effects 0.000 description 2
- 230000005101 cell tropism Effects 0.000 description 2
- 230000023549 cell-cell signaling Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229940001442 combination vaccine Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- 210000003754 fetus Anatomy 0.000 description 2
- 102000003977 fibroblast growth factor 18 Human genes 0.000 description 2
- 108090000370 fibroblast growth factor 18 Proteins 0.000 description 2
- 210000003953 foreskin Anatomy 0.000 description 2
- 229960005102 foscarnet Drugs 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 108010004142 galactose-3-O-sulfotransferase 3 Proteins 0.000 description 2
- 238000012239 gene modification Methods 0.000 description 2
- 230000005017 genetic modification Effects 0.000 description 2
- 235000013617 genetically modified food Nutrition 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 101150028578 grp78 gene Proteins 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 108040003607 interleukin-13 receptor activity proteins Proteins 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 108010026136 mouse tax-responsive-element-binding protein 107 Proteins 0.000 description 2
- 238000002703 mutagenesis Methods 0.000 description 2
- 231100000350 mutagenesis Toxicity 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 230000007110 pathogen host interaction Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 230000010837 receptor-mediated endocytosis Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 229940031626 subunit vaccine Drugs 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000010246 ultrastructural analysis Methods 0.000 description 2
- 210000003606 umbilical vein Anatomy 0.000 description 2
- 230000017613 viral reproduction Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
- 108010022379 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase Proteins 0.000 description 1
- MRAKLTZPBIBWFH-ARJAWSKDSA-N (z)-2-ethenylbut-2-enedioic acid Chemical compound OC(=O)\C=C(\C=C)C(O)=O MRAKLTZPBIBWFH-ARJAWSKDSA-N 0.000 description 1
- VZEUMRXJWIAEOK-UHFFFAOYSA-N 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one Chemical compound CCCCC(=O)C1=C(O)C(Cl)=C(OC)C(Cl)=C1O VZEUMRXJWIAEOK-UHFFFAOYSA-N 0.000 description 1
- FJLUATLTXUNBOT-UHFFFAOYSA-N 1-Hexadecylamine Chemical compound CCCCCCCCCCCCCCCCN FJLUATLTXUNBOT-UHFFFAOYSA-N 0.000 description 1
- SXGZJKUKBWWHRA-UHFFFAOYSA-N 2-(N-morpholiniumyl)ethanesulfonate Chemical compound [O-]S(=O)(=O)CC[NH+]1CCOCC1 SXGZJKUKBWWHRA-UHFFFAOYSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 description 1
- LHEJDBBHZGISGW-UHFFFAOYSA-N 5-fluoro-3-(3-oxo-1h-2-benzofuran-1-yl)-1h-pyrimidine-2,4-dione Chemical compound O=C1C(F)=CNC(=O)N1C1C2=CC=CC=C2C(=O)O1 LHEJDBBHZGISGW-UHFFFAOYSA-N 0.000 description 1
- 102100032650 A disintegrin and metalloproteinase with thrombospondin motifs 9 Human genes 0.000 description 1
- 102100028323 ADP-ribose glycohydrolase MACROD2 Human genes 0.000 description 1
- 101150059521 AHRR gene Proteins 0.000 description 1
- 241000208140 Acer Species 0.000 description 1
- 101150115490 Aldh1a3 gene Proteins 0.000 description 1
- 108020005098 Anticodon Proteins 0.000 description 1
- 101710127675 Antiviral innate immune response receptor RIG-I Proteins 0.000 description 1
- 102100023650 Aquaporin-11 Human genes 0.000 description 1
- 208000035671 Autosomal dominant Charcot-Marie-Tooth disease type 2A1 Diseases 0.000 description 1
- 102100040535 BTB/POZ domain-containing protein KCTD4 Human genes 0.000 description 1
- 108700003785 Baculoviral IAP Repeat-Containing 3 Proteins 0.000 description 1
- 102100021670 Bcl-2-modifying factor Human genes 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 101000849787 Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) Ribosome-recycling factor Proteins 0.000 description 1
- 102100024072 C2 calcium-dependent domain-containing protein 6 Human genes 0.000 description 1
- 102100032982 CCR4-NOT transcription complex subunit 9 Human genes 0.000 description 1
- 101100497948 Caenorhabditis elegans cyn-1 gene Proteins 0.000 description 1
- 101100203924 Caenorhabditis elegans sorb-1 gene Proteins 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 208000035758 Charcot-Marie-Tooth disease type 2S Diseases 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 102100027823 Complexin-2 Human genes 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 102100035185 DNA excision repair protein ERCC-6-like Human genes 0.000 description 1
- 102100039436 DNA-binding protein inhibitor ID-3 Human genes 0.000 description 1
- 102100027491 DNA-directed RNA polymerase I subunit RPA43 Human genes 0.000 description 1
- 101150043714 DUSP6 gene Proteins 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 101100010535 Drosophila melanogaster Mkp3 gene Proteins 0.000 description 1
- 201000001355 Duane-radial ray syndrome Diseases 0.000 description 1
- 102100040322 E3 ubiquitin-protein ligase RNF183 Human genes 0.000 description 1
- 102100031560 Excitatory amino acid transporter 3 Human genes 0.000 description 1
- 241000272186 Falco columbarius Species 0.000 description 1
- 101000764257 Gallus gallus Troponin T, cardiac muscle isoforms Proteins 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 102100021196 Glypican-5 Human genes 0.000 description 1
- 102100035910 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Human genes 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 108700039143 HMGA2 Proteins 0.000 description 1
- 102000049982 HMGA2 Human genes 0.000 description 1
- 101150052820 HXK2 gene Proteins 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 201000005398 Hermansky-Pudlak syndrome 7 Diseases 0.000 description 1
- 241000700586 Herpesviridae Species 0.000 description 1
- 229920000209 Hexadimethrine bromide Polymers 0.000 description 1
- 101000730039 Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 9 Proteins 0.000 description 1
- 101000578915 Homo sapiens ADP-ribose glycohydrolase MACROD2 Proteins 0.000 description 1
- 101000897856 Homo sapiens Adenylyl cyclase-associated protein 2 Proteins 0.000 description 1
- 101000959046 Homo sapiens Aldehyde dehydrogenase family 1 member A3 Proteins 0.000 description 1
- 101000952099 Homo sapiens Antiviral innate immune response receptor RIG-I Proteins 0.000 description 1
- 101000684459 Homo sapiens Aquaporin-11 Proteins 0.000 description 1
- 101000884385 Homo sapiens Arylamine N-acetyltransferase 1 Proteins 0.000 description 1
- 101000613899 Homo sapiens BTB/POZ domain-containing protein KCTD4 Proteins 0.000 description 1
- 101000896211 Homo sapiens Bcl-2-modifying factor Proteins 0.000 description 1
- 101000910418 Homo sapiens C2 calcium-dependent domain-containing protein 6 Proteins 0.000 description 1
- 101000937734 Homo sapiens Carotenoid-cleaving dioxygenase, mitochondrial Proteins 0.000 description 1
- 101000859628 Homo sapiens Complexin-2 Proteins 0.000 description 1
- 101000876524 Homo sapiens DNA excision repair protein ERCC-6-like Proteins 0.000 description 1
- 101001036287 Homo sapiens DNA-binding protein inhibitor ID-3 Proteins 0.000 description 1
- 101000650570 Homo sapiens DNA-directed RNA polymerase I subunit RPA43 Proteins 0.000 description 1
- 101001057587 Homo sapiens Dual specificity protein phosphatase 6 Proteins 0.000 description 1
- 101001104297 Homo sapiens E3 ubiquitin-protein ligase RNF183 Proteins 0.000 description 1
- 101001034811 Homo sapiens Eukaryotic translation initiation factor 4 gamma 2 Proteins 0.000 description 1
- 101000866302 Homo sapiens Excitatory amino acid transporter 3 Proteins 0.000 description 1
- 101001040711 Homo sapiens Glypican-5 Proteins 0.000 description 1
- 101001073272 Homo sapiens Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Proteins 0.000 description 1
- 101001037968 Homo sapiens Heat shock 70 kDa protein 1B Proteins 0.000 description 1
- 101100396286 Homo sapiens IER3 gene Proteins 0.000 description 1
- 101001003229 Homo sapiens Immediate early response gene 5-like protein Proteins 0.000 description 1
- 101000919167 Homo sapiens Inactive carboxypeptidase-like protein X2 Proteins 0.000 description 1
- 101000998810 Homo sapiens Insulin-like peptide INSL6 Proteins 0.000 description 1
- 101001082065 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 1 Proteins 0.000 description 1
- 101001037246 Homo sapiens Interleukin-27 receptor subunit alpha Proteins 0.000 description 1
- 101001006878 Homo sapiens Kelch-like protein 24 Proteins 0.000 description 1
- 101001091231 Homo sapiens Kinesin-like protein KIF18A Proteins 0.000 description 1
- 101000619643 Homo sapiens Ligand-dependent nuclear receptor-interacting factor 1 Proteins 0.000 description 1
- 101000731000 Homo sapiens Membrane-associated progesterone receptor component 1 Proteins 0.000 description 1
- 101000793966 Homo sapiens Mitochondrial protein C2orf69 Proteins 0.000 description 1
- 101000995194 Homo sapiens Nebulette Proteins 0.000 description 1
- 101000927793 Homo sapiens Neuroepithelial cell-transforming gene 1 protein Proteins 0.000 description 1
- 101000992392 Homo sapiens Oxysterol-binding protein-related protein 6 Proteins 0.000 description 1
- 101000987578 Homo sapiens Peripherin Proteins 0.000 description 1
- 101000596005 Homo sapiens Phospholipid scramblase 2 Proteins 0.000 description 1
- 101001096175 Homo sapiens Pleckstrin homology domain-containing family A member 4 Proteins 0.000 description 1
- 101001124937 Homo sapiens Pre-mRNA-splicing factor 38B Proteins 0.000 description 1
- 101000894618 Homo sapiens Pre-mRNA-splicing factor CWC22 homolog Proteins 0.000 description 1
- 101000775052 Homo sapiens Protein AHNAK2 Proteins 0.000 description 1
- 101000877827 Homo sapiens Protein FAM183BP Proteins 0.000 description 1
- 101001017783 Homo sapiens Protein LRATD2 Proteins 0.000 description 1
- 101000713957 Homo sapiens Protein RUFY3 Proteins 0.000 description 1
- 101000652820 Homo sapiens Protein shisa-like-1 Proteins 0.000 description 1
- 101000738772 Homo sapiens Receptor-type tyrosine-protein phosphatase beta Proteins 0.000 description 1
- 101001095431 Homo sapiens Rhox homeobox family member 1 Proteins 0.000 description 1
- 101000740178 Homo sapiens Sal-like protein 4 Proteins 0.000 description 1
- 101000694017 Homo sapiens Sodium channel protein type 5 subunit alpha Proteins 0.000 description 1
- 101000631937 Homo sapiens Sodium- and chloride-dependent glycine transporter 2 Proteins 0.000 description 1
- 101000629631 Homo sapiens Sorbin and SH3 domain-containing protein 1 Proteins 0.000 description 1
- 101000685001 Homo sapiens Stromal cell-derived factor 2-like protein 1 Proteins 0.000 description 1
- 101000940176 Homo sapiens Telomere zinc finger-associated protein Proteins 0.000 description 1
- 101001095487 Homo sapiens Telomere-associated protein RIF1 Proteins 0.000 description 1
- 101000759303 Homo sapiens Tetratricopeptide repeat protein 13 Proteins 0.000 description 1
- 101000844686 Homo sapiens Thioredoxin reductase 1, cytoplasmic Proteins 0.000 description 1
- 101000648265 Homo sapiens Thymocyte selection-associated high mobility group box protein TOX Proteins 0.000 description 1
- 101000904499 Homo sapiens Transcription regulator protein BACH2 Proteins 0.000 description 1
- 101000798702 Homo sapiens Transmembrane protease serine 4 Proteins 0.000 description 1
- 101000868045 Homo sapiens Uncharacterized protein C1orf87 Proteins 0.000 description 1
- 101000910934 Homo sapiens Uncharacterized protein C2orf78 Proteins 0.000 description 1
- 101000914632 Homo sapiens Uncharacterized protein C8orf58 Proteins 0.000 description 1
- 101000743584 Homo sapiens Vacuolar protein sorting-associated protein 26B Proteins 0.000 description 1
- 101000750267 Homo sapiens Vasorin Proteins 0.000 description 1
- 101000760214 Homo sapiens Zinc finger protein 33A Proteins 0.000 description 1
- 101000760182 Homo sapiens Zinc finger protein 45 Proteins 0.000 description 1
- 101000785680 Homo sapiens Zinc finger protein 512 Proteins 0.000 description 1
- 101000964571 Homo sapiens Zinc finger protein 69 homolog B Proteins 0.000 description 1
- 101000644602 Homo sapiens tRNA wybutosine-synthesizing protein 3 homolog Proteins 0.000 description 1
- 108010056651 Hydroxymethylbilane synthase Proteins 0.000 description 1
- 101150002750 IFIT1 gene Proteins 0.000 description 1
- 102100020701 Immediate early response gene 5-like protein Human genes 0.000 description 1
- 108700002232 Immediate-Early Genes Proteins 0.000 description 1
- 102100029326 Inactive carboxypeptidase-like protein X2 Human genes 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 108010020950 Integrin beta3 Proteins 0.000 description 1
- 101710197212 Interferon-induced protein 44 Proteins 0.000 description 1
- 101710166699 Interferon-induced protein with tetratricopeptide repeats 1 Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 108010002386 Interleukin-3 Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 108091092195 Intron Proteins 0.000 description 1
- 102100027794 Kelch-like protein 24 Human genes 0.000 description 1
- 102100034895 Kinesin-like protein KIF18A Human genes 0.000 description 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 1
- 101710128836 Large T antigen Proteins 0.000 description 1
- 102100022172 Ligand-dependent nuclear receptor-interacting factor 1 Human genes 0.000 description 1
- 108091007767 MALAT1 Proteins 0.000 description 1
- 102000043136 MAP kinase family Human genes 0.000 description 1
- 108091054455 MAP kinase family Proteins 0.000 description 1
- 102000009571 Macrophage Inflammatory Proteins Human genes 0.000 description 1
- 108010009474 Macrophage Inflammatory Proteins Proteins 0.000 description 1
- 102100032399 Membrane-associated progesterone receptor component 1 Human genes 0.000 description 1
- 101100524295 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) relB3 gene Proteins 0.000 description 1
- 102100029885 Mitochondrial protein C2orf69 Human genes 0.000 description 1
- 102000007474 Multiprotein Complexes Human genes 0.000 description 1
- 108010085220 Multiprotein Complexes Proteins 0.000 description 1
- 101000854950 Mus musculus Wings apart-like protein homolog Proteins 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 102100034431 Nebulette Human genes 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241001028048 Nicola Species 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 241001165050 Ocala Species 0.000 description 1
- REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 101100232286 Oryza sativa subsp. japonica HXK6 gene Proteins 0.000 description 1
- 102100032149 Oxysterol-binding protein-related protein 6 Human genes 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- BFHAYPLBUQVNNJ-UHFFFAOYSA-N Pectenotoxin 3 Natural products OC1C(C)CCOC1(O)C1OC2C=CC(C)=CC(C)CC(C)(O3)CCC3C(O3)(O4)CCC3(C=O)CC4C(O3)C(=O)CC3(C)C(O)C(O3)CCC3(O3)CCCC3C(C)C(=O)OC2C1 BFHAYPLBUQVNNJ-UHFFFAOYSA-N 0.000 description 1
- 102100035170 Phospholipid scramblase 2 Human genes 0.000 description 1
- 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 101710189720 Porphobilinogen deaminase Proteins 0.000 description 1
- 101710170827 Porphobilinogen deaminase, chloroplastic Proteins 0.000 description 1
- 102100032709 Potassium-transporting ATPase alpha chain 2 Human genes 0.000 description 1
- 102100021427 Pre-mRNA-splicing factor CWC22 homolog Human genes 0.000 description 1
- 101710100896 Probable porphobilinogen deaminase Proteins 0.000 description 1
- 102100031838 Protein AHNAK2 Human genes 0.000 description 1
- 102100035469 Protein FAM183BP Human genes 0.000 description 1
- 102100033355 Protein LRATD2 Human genes 0.000 description 1
- 102100036452 Protein RUFY3 Human genes 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 102100030927 Protein shisa-like-1 Human genes 0.000 description 1
- 239000013614 RNA sample Substances 0.000 description 1
- 102100037424 Receptor-type tyrosine-protein phosphatase beta Human genes 0.000 description 1
- 206010038910 Retinitis Diseases 0.000 description 1
- 102100037751 Rhox homeobox family member 1 Human genes 0.000 description 1
- 108060007764 SLC6A5 Proteins 0.000 description 1
- 108091006683 SLCO4A1 Proteins 0.000 description 1
- 102100037192 Sal-like protein 4 Human genes 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 102100025520 Serpin B8 Human genes 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102100037202 Sodium/myo-inositol cotransporter 2 Human genes 0.000 description 1
- 101710090560 Sodium/myo-inositol cotransporter 2 Proteins 0.000 description 1
- 101710093289 Solute carrier organic anion transporter family member 4A1 Proteins 0.000 description 1
- 102100026834 Sorbin and SH3 domain-containing protein 1 Human genes 0.000 description 1
- 206010041660 Splenomegaly Diseases 0.000 description 1
- 102100023183 Stromal cell-derived factor 2-like protein 1 Human genes 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- 101710137500 T7 RNA polymerase Proteins 0.000 description 1
- 102100031146 Telomere zinc finger-associated protein Human genes 0.000 description 1
- 102100023285 Tetratricopeptide repeat protein 13 Human genes 0.000 description 1
- 102100031208 Thioredoxin reductase 1, cytoplasmic Human genes 0.000 description 1
- 101710150060 Thioredoxin-dependent peroxide reductase, mitochondrial Proteins 0.000 description 1
- 102100028788 Thymocyte selection-associated high mobility group box protein TOX Human genes 0.000 description 1
- YTGJWQPHMWSCST-UHFFFAOYSA-N Tiopronin Chemical compound CC(S)C(=O)NCC(O)=O YTGJWQPHMWSCST-UHFFFAOYSA-N 0.000 description 1
- 108010058907 Tiopronin Proteins 0.000 description 1
- 102000004380 Transcription factor RelB Human genes 0.000 description 1
- 108090000952 Transcription factor RelB Proteins 0.000 description 1
- 102100035100 Transcription factor p65 Human genes 0.000 description 1
- 101710102923 Transcription factor p65 Proteins 0.000 description 1
- 102100023998 Transcription regulator protein BACH2 Human genes 0.000 description 1
- 102100032471 Transmembrane protease serine 4 Human genes 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 101710165323 Troponin T, cardiac muscle Proteins 0.000 description 1
- 101150032047 UL131 gene Proteins 0.000 description 1
- 102100032994 Uncharacterized protein C1orf87 Human genes 0.000 description 1
- 102100026669 Uncharacterized protein C2orf78 Human genes 0.000 description 1
- 102100027226 Uncharacterized protein C8orf58 Human genes 0.000 description 1
- 206010046851 Uveitis Diseases 0.000 description 1
- 102100038402 Vacuolar protein sorting-associated protein 26B Human genes 0.000 description 1
- 102100021161 Vasorin Human genes 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 102100026524 Zinc finger protein 512 Human genes 0.000 description 1
- 102100040797 Zinc finger protein 69 homolog B Human genes 0.000 description 1
- 229960004308 acetylcysteine Drugs 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
- SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 description 1
- 238000012197 amplification kit Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229930192649 bafilomycin Natural products 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000007698 birth defect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 108091092328 cellular RNA Proteins 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000002962 chemical mutagen Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- HISOCSRUFLPKDE-KLXQUTNESA-N cmt-2 Chemical compound C1=CC=C2[C@](O)(C)C3CC4C(N(C)C)C(O)=C(C#N)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O HISOCSRUFLPKDE-KLXQUTNESA-N 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000003636 conditioned culture medium Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 229960002086 dextran Drugs 0.000 description 1
- 229960000633 dextran sulfate Drugs 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000003596 drug target Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000797 effect on infection Effects 0.000 description 1
- 238000010218 electron microscopic analysis Methods 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 230000017188 evasion or tolerance of host immune response Effects 0.000 description 1
- 239000013613 expression plasmid Substances 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 238000003209 gene knockout Methods 0.000 description 1
- 230000008570 general process Effects 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 201000010551 hypertrophic cardiomyopathy 2 Diseases 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000013338 intended final formulation Methods 0.000 description 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
- 230000004068 intracellular signaling Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229960003151 mercaptamine Drugs 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 238000002966 oligonucleotide array Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000006174 pH buffer Substances 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 101150025785 pcn1 gene Proteins 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 102000030592 phosphoserine aminotransferase Human genes 0.000 description 1
- 108010088694 phosphoserine aminotransferase Proteins 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- 238000002962 plaque-reduction assay Methods 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- ODLMAHJVESYWTB-UHFFFAOYSA-N propylbenzene Chemical compound CCCC1=CC=CC=C1 ODLMAHJVESYWTB-UHFFFAOYSA-N 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000011663 regulation of signaling Effects 0.000 description 1
- 101150023313 relB gene Proteins 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 101150005835 scly gene Proteins 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000013337 sub-cultivation Methods 0.000 description 1
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000017960 syncytium formation Effects 0.000 description 1
- 102100020794 tRNA wybutosine-synthesizing protein 3 homolog Human genes 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960004402 tiopronin Drugs 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 210000004926 tubular epithelial cell Anatomy 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 230000007442 viral DNA synthesis Effects 0.000 description 1
- 230000006648 viral gene expression Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16161—Methods of inactivation or attenuation
- C12N2710/16164—Methods of inactivation or attenuation by serial passage
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99842607P | 2007-10-10 | 2007-10-10 | |
| PCT/US2008/079494 WO2009049138A1 (en) | 2007-10-10 | 2008-10-10 | Cytomegalovirus vaccines and methods of production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ584459A true NZ584459A (en) | 2012-06-29 |
Family
ID=40549581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ584459A NZ584459A (en) | 2007-10-10 | 2008-10-10 | Cytomegalovirus vaccines and methods of production |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9439960B2 (https=) |
| EP (1) | EP2200645B1 (https=) |
| JP (1) | JP5409638B2 (https=) |
| KR (1) | KR20100084627A (https=) |
| CN (1) | CN101820906B (https=) |
| AU (1) | AU2008310713B2 (https=) |
| BR (1) | BRPI0818656A2 (https=) |
| CA (1) | CA2701727C (https=) |
| IL (1) | IL204850A0 (https=) |
| MX (1) | MX2010003713A (https=) |
| NZ (1) | NZ584459A (https=) |
| RU (1) | RU2491340C2 (https=) |
| SG (1) | SG185291A1 (https=) |
| WO (1) | WO2009049138A1 (https=) |
| ZA (1) | ZA201002216B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9439960B2 (en) | 2007-10-10 | 2016-09-13 | The Trustees Of Princeton University | Cytomegalovirus vaccines and methods of production |
| US8580276B2 (en) | 2009-06-05 | 2013-11-12 | City Of Hope | Genetically stable recombinant modified vaccinia ankara (rMVA) vaccines and methods of preparation thereof |
| TWI570240B (zh) * | 2011-09-09 | 2017-02-11 | 默沙東公司 | 作為細胞巨大病毒疫苗之條件式複製ｃｍｖ |
| KR102314245B1 (ko) * | 2012-03-27 | 2021-10-20 | 배리에이션 바이오테크놀로지스 아이엔씨. | 항-사이토메갈로바이러스 중화 항체를 탐지하기 위한 방법 |
| ES2753138T3 (es) | 2012-07-06 | 2020-04-07 | Glaxosmithkline Biologicals Sa | Complejos de proteínas de citomegalovirus |
| DK2877580T3 (en) | 2012-07-27 | 2019-04-23 | Hope City | VAT VACCINE TO DELIVER A UL128 COMPLEX AND PREVENT CMV INFECTION |
| US9395369B2 (en) | 2012-10-19 | 2016-07-19 | Regents Of The University Of Minnesota | Guinea pig cytomegalovirus (CIDMTR strain) |
| CN103937871B (zh) * | 2013-01-23 | 2019-07-23 | 上海市东方医院 | Srrp35基因和表达产物在癌症诊断与治疗中的应用 |
| EP3068431A4 (en) * | 2013-11-15 | 2017-08-23 | President and Fellows of Harvard College | Methods and compositions for the treatment of hcmv |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| EP3601543A4 (en) * | 2017-03-30 | 2021-01-27 | Merck Sharp & Dohme Corp. | ADDING NUCLEASES DIRECTLY TO CELL CULTURE TO FACILITATE DIGESTION AND RELEASE OF HOST CELL NUCLEIC ACIDS |
| CA3060019A1 (en) * | 2017-04-19 | 2018-10-25 | Glaxosmithkline Biologicals Sa | Modified cytomegalovirus proteins and stabilized complexes |
| MX2020004434A (es) * | 2017-11-01 | 2020-08-06 | Merck Sharp & Dohme | Formulaciones estables de citomegalovirus. |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| TWI810589B (zh) | 2020-06-21 | 2023-08-01 | 美商輝瑞股份有限公司 | 人巨細胞病毒糖蛋白Ｂ（ｇＢ）多肽 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3959466A (en) | 1974-04-15 | 1976-05-25 | The Wistar Institute | Highly attenuated cytomegalovirus vaccine and production thereof |
| US4058598A (en) | 1974-10-18 | 1977-11-15 | Harold Stern | Cytomegalovirus attenuation method and vaccine |
| US6471965B1 (en) | 1994-07-27 | 2002-10-29 | Bio-Virus Research Incorporated | Vaccine containing whole killed herpes viruses to prevent development of atherosclerotic plaque |
| DE10144906B4 (de) * | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
| US7407744B2 (en) | 2003-07-25 | 2008-08-05 | The Regents Of The University Of California | Cytomegalovirus gene function and methods for developing antivirals, anti-CMV vaccines, and CMV-based vectors |
| EP3031469B1 (en) * | 2006-06-07 | 2023-08-23 | The Trustees Of Princeton University | Cytomegalovirus surface protein complex for use in vaccines and as a drug target |
| US9439960B2 (en) | 2007-10-10 | 2016-09-13 | The Trustees Of Princeton University | Cytomegalovirus vaccines and methods of production |
-
2008
- 2008-10-01 US US12/681,504 patent/US9439960B2/en active Active
- 2008-10-10 NZ NZ584459A patent/NZ584459A/en not_active IP Right Cessation
- 2008-10-10 SG SG2012075594A patent/SG185291A1/en unknown
- 2008-10-10 AU AU2008310713A patent/AU2008310713B2/en not_active Ceased
- 2008-10-10 JP JP2010529076A patent/JP5409638B2/ja not_active Expired - Fee Related
- 2008-10-10 CA CA2701727A patent/CA2701727C/en active Active
- 2008-10-10 MX MX2010003713A patent/MX2010003713A/es active IP Right Grant
- 2008-10-10 EP EP08836810.5A patent/EP2200645B1/en active Active
- 2008-10-10 WO PCT/US2008/079494 patent/WO2009049138A1/en not_active Ceased
- 2008-10-10 KR KR1020107008187A patent/KR20100084627A/ko not_active Withdrawn
- 2008-10-10 RU RU2010117741/10A patent/RU2491340C2/ru not_active IP Right Cessation
- 2008-10-10 BR BRPI0818656-1A patent/BRPI0818656A2/pt not_active IP Right Cessation
- 2008-10-10 CN CN200880111084.9A patent/CN101820906B/zh not_active Expired - Fee Related
-
2010
- 2010-03-29 ZA ZA2010/02216A patent/ZA201002216B/en unknown
- 2010-04-06 IL IL204850A patent/IL204850A0/en unknown
-
2016
- 2016-07-29 US US15/223,980 patent/US10300130B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2701727C (en) | 2016-12-13 |
| EP2200645A4 (en) | 2012-07-11 |
| US9439960B2 (en) | 2016-09-13 |
| EP2200645A1 (en) | 2010-06-30 |
| BRPI0818656A2 (pt) | 2015-04-14 |
| AU2008310713A1 (en) | 2009-04-16 |
| ZA201002216B (en) | 2011-06-29 |
| CA2701727A1 (en) | 2009-04-16 |
| JP2011500592A (ja) | 2011-01-06 |
| US20170014504A1 (en) | 2017-01-19 |
| KR20100084627A (ko) | 2010-07-27 |
| CN101820906A (zh) | 2010-09-01 |
| JP5409638B2 (ja) | 2014-02-05 |
| CN101820906B (zh) | 2015-04-22 |
| SG185291A1 (en) | 2012-11-29 |
| IL204850A0 (en) | 2010-11-30 |
| RU2491340C2 (ru) | 2013-08-27 |
| US20100285059A1 (en) | 2010-11-11 |
| EP2200645B1 (en) | 2016-01-27 |
| AU2008310713B2 (en) | 2012-06-14 |
| MX2010003713A (es) | 2010-08-02 |
| US10300130B2 (en) | 2019-05-28 |
| WO2009049138A1 (en) | 2009-04-16 |
| RU2010117741A (ru) | 2011-11-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10300130B2 (en) | Cytomegalovirus vaccines and methods of production | |
| JP5926804B2 (ja) | Ｃｍｖ用ワクチンとしての条件付き複製サイトメガロウイルス | |
| US20130045230A1 (en) | Composition containing hcmv particles | |
| KR20160018828A (ko) | 불활성화된 바리셀라 조스터 바이러스 백신, 그의 제조 방법 및 용도 | |
| HK40010150A (en) | A conditional replicating cytomegalovirus as a vaccine for cmv | |
| HK1240107B (en) | A conditional replicating cytomegalovirus as a vaccine for cmv | |
| HK1240107A (en) | A conditional replicating cytomegalovirus as a vaccine for cmv | |
| HK1240107A1 (en) | A conditional replicating cytomegalovirus as a vaccine for cmv | |
| HK1194283B (en) | A conditional replicating cytomegalovirus as a vaccine for cmv | |
| HK1194283A (en) | A conditional replicating cytomegalovirus as a vaccine for cmv |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 10 OCT 2016 BY COMPUTER PACKAGES INC Effective date: 20150918 |
|
| LAPS | Patent lapsed |