NZ522317A - A combination of pinitol and creatine to enhance uptake and retention of creatine in muscle tissue - Google Patents
A combination of pinitol and creatine to enhance uptake and retention of creatine in muscle tissueInfo
- Publication number
- NZ522317A NZ522317A NZ522317A NZ52231701A NZ522317A NZ 522317 A NZ522317 A NZ 522317A NZ 522317 A NZ522317 A NZ 522317A NZ 52231701 A NZ52231701 A NZ 52231701A NZ 522317 A NZ522317 A NZ 522317A
- Authority
- NZ
- New Zealand
- Prior art keywords
- creatine
- pinitol
- composition
- administration
- grams
- Prior art date
Links
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 title claims abstract description 146
- 229960003624 creatine Drugs 0.000 title claims abstract description 73
- 239000006046 creatine Substances 0.000 title claims abstract description 73
- DSCFFEYYQKSRSV-UHFFFAOYSA-N 1L-O1-methyl-muco-inositol Natural products COC1C(O)C(O)C(O)C(O)C1O DSCFFEYYQKSRSV-UHFFFAOYSA-N 0.000 title claims abstract description 58
- VJXUJFAZXQOXMJ-UHFFFAOYSA-N D-1-O-Methyl-muco-inositol Natural products CC12C(OC)(C)OC(C)(C)C2CC(=O)C(C23OC2C(=O)O2)(C)C1CCC3(C)C2C=1C=COC=1 VJXUJFAZXQOXMJ-UHFFFAOYSA-N 0.000 title claims abstract description 58
- DSCFFEYYQKSRSV-KLJZZCKASA-N D-pinitol Chemical compound CO[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@H]1O DSCFFEYYQKSRSV-KLJZZCKASA-N 0.000 title claims abstract description 50
- 210000003205 muscle Anatomy 0.000 title claims abstract description 16
- 230000014759 maintenance of location Effects 0.000 title claims abstract description 10
- 239000002207 metabolite Substances 0.000 claims abstract description 9
- 206010028311 Muscle hypertrophy Diseases 0.000 claims abstract description 8
- 230000012042 muscle hypertrophy Effects 0.000 claims abstract description 8
- 230000002195 synergetic effect Effects 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 58
- 239000000203 mixture Substances 0.000 claims description 24
- 239000004480 active ingredient Substances 0.000 claims description 13
- -1 pinitol glycosides Chemical class 0.000 claims description 11
- 241000124008 Mammalia Species 0.000 claims description 10
- 239000004615 ingredient Substances 0.000 claims description 8
- 150000001720 carbohydrates Chemical class 0.000 claims description 6
- 102100028701 General vesicular transport factor p115 Human genes 0.000 claims description 5
- 101000767151 Homo sapiens General vesicular transport factor p115 Proteins 0.000 claims description 5
- 230000037058 blood plasma level Effects 0.000 claims description 5
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- 235000021317 phosphate Nutrition 0.000 claims description 3
- 229930182470 glycoside Natural products 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims description 2
- 235000002949 phytic acid Nutrition 0.000 claims description 2
- MEJYXFHCRXAUIL-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid;hydrate Chemical group O.NC(=N)N(C)CC(O)=O MEJYXFHCRXAUIL-UHFFFAOYSA-N 0.000 claims 5
- 229960004826 creatine monohydrate Drugs 0.000 claims 5
- 239000000843 powder Substances 0.000 claims 5
- 230000008512 biological response Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000000663 muscle cell Anatomy 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 230000000386 athletic effect Effects 0.000 claims 1
- 235000012054 meals Nutrition 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- AMHZIUVRYRVYBA-UHFFFAOYSA-N 2-(2-amino-4,5-dihydroimidazol-1-yl)acetic acid Chemical compound NC1=NCCN1CC(O)=O AMHZIUVRYRVYBA-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- DRBBFCLWYRJSJZ-UHFFFAOYSA-N N-phosphocreatine Chemical compound OC(=O)CN(C)C(=N)NP(O)(O)=O DRBBFCLWYRJSJZ-UHFFFAOYSA-N 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 150000004682 monohydrates Chemical class 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- DSCFFEYYQKSRSV-FEPQRWDDSA-N (1s,2s,4s,5r)-6-methoxycyclohexane-1,2,3,4,5-pentol Chemical compound COC1[C@@H](O)[C@@H](O)C(O)[C@H](O)[C@H]1O DSCFFEYYQKSRSV-FEPQRWDDSA-N 0.000 description 1
- CDAISMWEOUEBRE-LKPKBOIGSA-N 1D-chiro-inositol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-LKPKBOIGSA-N 0.000 description 1
- MBBREGJRSROLGD-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound NC(=N)N(C)CC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O MBBREGJRSROLGD-UHFFFAOYSA-N 0.000 description 1
- DLNGCCQFGNSBOP-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid;2-oxopropanoic acid Chemical compound CC(=O)C(O)=O.NC(=N)N(C)CC(O)=O DLNGCCQFGNSBOP-UHFFFAOYSA-N 0.000 description 1
- 241000219475 Bougainvillea Species 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 240000004658 Medicago sativa Species 0.000 description 1
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 240000004713 Pisum sativum Species 0.000 description 1
- 235000010582 Pisum sativum Nutrition 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 229940072107 ascorbate Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229940059082 douche Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Muscle performance can be improved and muscle hypertrophy enhanced, through enhanced uptake and retention of creatine resulting in improved ATP re-synthesis, by administering an effective synergistic amount of a combination of creatine or an active derivative thereof and pinitol or an active derivative or metabolite thereof.
Description
New Zealand Paient Spedficaiion for Paient Number 522317
522317
wo 01/80853 pct/us01/12485
A COMBINATION OF PINITOL AND CREATINE TO ENHANCE UPTAKE AND RETENTION OF CREATINE
Field of the Invention
The invention relates to the use of pharmaceuticals and dietary supplements to enhance Hie uptake and retention of creatine in muscle, tissue.
Background
Creatine phosphate is an excellent source of immediately available energy, capable of fueling the resynthesis of ATP from ADP.
Creatine is not synthesized in muscle tissue, but is transported to muscle tissue by the blood stream. Mankind has sought ways to accelerate ATP resynthesis and improve muscle power and performance by enhancing creatine uptake and retention by the muscle tissue. Such efforts range from the consumption of mass quantities of creatine to the administration of a combination of creatine and any of a variety of adjuvants, such as insulin and/or a carbohydrate.
While certain of these techniques have demonstrated limited success in enhancing creatine uptake and/or retention in muscle tissues, the search continues for safe alternative means for improving muscle performance by enhancing creatine uptake and retention in muscle tissue.
PCT/USO1/12485
Summary of the Invention
We have discovered that muscle performance can be improved and muscle hypertrophy enhanced, through enhanced uptake and retention of creatine 5 resulting in improved ATP resynthesis, by administering an effective synergistic amount of a combination of creatine or an active derivative thereof and pinitol or an active derivative or metabolite thereof.
io Detailed Description of the Invention
Including a Best Mode
The First Active Ingredient
The first active ingredient is creatine or an active derivative thereof.
Creatine has the structure shown below in Figure 1.
CH„
l3
COOH HH2
Creatine is commercially isolated from meat extracts and is available from a number of sources. Creatine is generally available and suitable for use in the 25 invention as a monohydrate, with the monohydrate converted to anhydrous form at about 100°C.
Suitable derivatives of creatine include creatine phosphates, creatine citrate, creatine ascorbate, creatine pyruvate, cyclo-creatine and other salts thereof.
2
WO 01/80853 PCT/US01/12485
The Second Active Ingredient
The second active ingredient is pinitol or an active derivative or metabolite thereof. Pinitol has the structure shown below in Figure 2.
OH
QH
^/odh
OH OH
Pinitol can be extracted from a number of plant sources, including alfalfa, Bougainvillea leaves, chick peas, pine trees and soy beans, and is commercially available from Humanetics Coiporation under the trademark Inzitol™.
Suitable derivatives and metabolites of pinitol include pinitol glycosides, pinitol phospholipids, esterified pinitol, lipid-bound pinitol, pinitol phosphates, pinitol phytates, and hydrolyzed pinitol such as d-chiro-inositol.
Optional Third Active Ingredient
Hie composition can optionally include a third active ingredient of a carbohydrate or an active derivative thereof (i.e., an organic aldehyde or ketone compound having multiple hydroxyl groups). The carbohydrate is preferably a simple carbohydrate, such as fructose or glucose.
Administration
Administration Route
The active ingredients can be administered to any mammal, including humans, for whom an improvement in muscle performance and/or enhanced muscle hypertrophy is desired.
PCT/USO1/12485
The active ingredients can be administered individually or together by virtually any of the commonly accepted practices for the administration of pharmaceutical preparations and dietary supplements including specifically, but not exclusively, mucosal administration, oral consumption, ocular administration, 5 subcutaneous injection, transdermal administration, etc. In order to achieve the desired synergistic effect, the creatine and pinitol should be administered so that the blood plasma level of pinitol is elevated simultaneously with or prior to administration of creatine. In a preferred embodiment, the creatine and pinitol are blended together in a single composition and administered together.
Mucosal administration of the active ingredients includes such routes as buccal, endotracheal, nasal, pharyngeal, rectal, sublingual, vaginal, etc. For administration through the buccal/sublingual/pharyngeal/endotracheal mucosa, the ingredients may be formulated as an emulsion, gum, lozenge, spray, tablet or an 15 inclusion complex such as cyclodextrin inclusion complexes. Nasal administration is conveniently conducted through the use of a sniffing power or nasal spray. For rectal and vaginal administration, the ingredients may be formulated as a cream, douche, enema or suppository.
Oral consumption of the active ingredients may be effected by incorporating the ingredients into a food or drink, formulating the ingredients into a chewable or swallowable tablet, or formulating the ingredients as a powdered or granular dietary supplement.
Ocular administration may be effected by incorporating the active ingredients into a solution or suspension adapted for ocular application such as drops or sprays.
Subcutaneous administration involves incorporating the active 30 ingredients into a pharmaceutically acceptable and injectable carrier.
Claims (63)
1. A composition effective for increasing retention of creatine in a mammal, comprising:
(a) pinitol or an active derivative or metabolite thereof selected from pinitol glycosides, pinitol phospholipids, esterified pinitol, lipid-bound pinitol, pinitol phosphates and pinitol phytates, and
(b) creatine or an active derivative thereof.
2. The composition of claim 1 wherein the creatine is creatine monohydrate.
3. The composition of claim 1 wherein the weight ratio of pinitol or active 10 derivative or metabolite thereof to creatine or active derivative thereof is between 1:10,000 to 1:1.
4. The composition of claim 1 wherein the composition is in powder or granular form.
15
5. The composition of claim 1 wherein the composition is in tablet form.
20
7.
The composition of claim 1 wherein the composition further includes a carbohydrate or an active derivative thereof.
A method of increasing creatine retention in a mammal comprising substantially simultaneously increasing the blood plasma level of creatine and pinitol.
25
8. The method of claim 7 wherein the mammal is a human.
9. The method of claim 7 wherein the blood plasma level of creatine is increased by the administration of creatine.
30 10. The method of claim 9 wherein the administration of creatine comprises oral consumption of creatine.
11. Hie method of claim 10 wherein the creatine is creatine monohydrate.
intellectual property office OF n.z.
19 APR 2004 RECEIVED
' intellectual property office of n.z.
1 9 APR 2004
WO 01/80853
PCT/USO1/12485
12. The method of claim 7 wherein the blood plasma level of pinitol is increased by the administration of pinitol.
5 13. The method of claim 12 wherein the administration of pinitol comprises oral consumption of pinitol.
14. The method of claim 10 wherein the blood plasma level of pinitol is increased by the oral consumption of pinitol.
10
15. The method of claim 14 wherein the weight ratio of pinitol to creatine is between 1:10,000 to 1:1.
16. The method of claim 14 wherein the composition is in powder or granular 15 form.
17. The method of claim 14 wherein the composition is in tablet form.
18. The method of claim 14 wherein the composition is consumed daily.
20
19. The method of claim 14 wherein at least 5 grams of creatine and at least 2 mg of pinitol are consumed daily.
20. The metliod of claim 19 wherein at least 5 grams of creatine and at least 10 mg 25, of pinitol are consumed daily.
21. A method of increasing cell up-take of creatine in a mammal comprising the substantially simultaneous administration of creatine or active derivative thereof and pinitol or active derivative or metabolite thereof.
30
22. The method of claim 21 wherein the mammal is a human.
7
WO 01/80853
PCT/US01/12485
23. The method of claim 22 wherein the administration of creatine comprises oral consumption of creatine.
24. The method of claim 23 wherein the creatine is creatine monohydrate.
5
25. The method of claim 22 wherein the administration of pinitol comprises oral consumption of pinitol.
26. The method of claim 25 wherein the administration of creatine comprises oral
10 consumption of creatine.
27. The method of claim 26 wherein the weight ratio of pinitol to creatine is between 1:10,000 to 1:1.
15 28. The method of claim 27 wherein the composition is in powder or granular form.
29. The method of claim 27 wherein the composition is in tablet form.
20
30. The method of claim 27 wherein the composition is consumed daily.
i
31. The method of claim 27 wherein at least 2 mg of pinitol and at least 5 grams of creatine are consumed daily.
25 32. The method of claim 31 wherein at least 10 mg of pinitol and at least 5 grams of creatine are consumed daily.
3 3. The method of claim 22 wherein the method of increasing cell up-take of creatine comprises increasing muscle cell up-take of creatine.
30
34. A method of accelerating ATP resynthesis in a mammal comprising the substantially simultaneous administration of creatine or active derivative thereof and pinitol or active derivative or metabolite thereof. ,
8
WO 01/80853 PCT/US01/12485
35. The method of claim 34 wherein the mammal is a human.
36. The method of claim 3 5 wherein the administration of creatine comprises oral
5 consumption of creatine.
3 7. The method of claim 36 wherein the creatine is creatine monohydrate.
3 8. The method of claim 3 5 wherein the administration of pinitol comprises oral
10 consumption of pinitol.
39. The method of claim 38 wherein the administration of creatine comprises oral consumption of creatine.
15 40. The method of claim 39 wherein the weight ratio of pinitol to creatine is between 1:10,000 to 1:1.
41. The method of claim 40 wherein the composition is in powder or granular form.
20
42. The method of claim 40 wherein the composition is in tablet form.
43. The method of claim 40 wherein the composition is consumed daily.
25 44. The method of claim 40 wherein at least 2 mg of pinitol and at least 5 grams of creatine are consumed daily.
45. The method of claim 44 wherein at least 10 mg of pinitol and at least 5 grams of creatine are consumed daily.
30
46. The method of claim 22 wherein the method of accelerating the rate of ATP resynthesis comprises accelerating the rate of ATP resynthesis in muscle cells.
WO 01/80853 PCT/US01/12485
47. A method of increasing muscle hypertrophy in a mammal comprising the substantially simultaneous administration of creatine or active derivative thereof and pinitol or active derivative or metabolite thereof.
5 48. The method of claim 47 wherein the mammal is a human.
49. The method of claim 48 wherein the administration of creatine comprises oral consumption of creatine.
10 50. The method of claim 49 wherein the creatine is creatine monohydrate.
51. The method of claim 48 wherein the administration of pinitol comprises oral consumption of pinitol.
15 52. The method of claim 51 wherein the administration of creatine comprises oral consumption of creatine.
53. The method of claim 52 wherein the weight ratio of pinitol to creatine is between 1:10,000 to 1:1.
20
25
30
54. The method of claim 53 wherein the composition is in powder or granular form.
55. The method of claim 53 wherein the composition is in tablet form.
56. The method of claim 53 wherein the composition is consumed daily.
57. The method of claim 53 wherein at least 2 mg of pinitol and at least 5 grams of creatine are consumed daily.
58. The method of claim 57 wherein at least 10 mg of pinitol and at least 5 grams of creatine are consumed daily.
10
11
.5223
59.
A composition according to claim 1 substantially as herein described or exemplified.
60.
A method according to claim 7 substantially as herein described or exemplified.
61.
A method according to claim 21 substantially as herein described or exemplified.
62.
A method according to claim 34 substantially as herein described or exemplified.
63.
A method according to claim 47 substantially as herein described or exemplified.
END OF CLAIMS
intellectual property OFFICE OF N.Z.
- 4 APR 2003 RECEIVED
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19839000P | 2000-04-19 | 2000-04-19 | |
| PCT/US2001/012485 WO2001080853A1 (en) | 2000-04-19 | 2001-04-16 | A combination of pinitol and creatine to enhance uptake and retention of creatine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ522317A true NZ522317A (en) | 2004-05-28 |
Family
ID=22733189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ522317A NZ522317A (en) | 2000-04-19 | 2001-04-16 | A combination of pinitol and creatine to enhance uptake and retention of creatine in muscle tissue |
Country Status (5)
| Country | Link |
|---|---|
| AU (2) | AU5359801A (en) |
| CA (1) | CA2405992A1 (en) |
| GB (1) | GB2377639B (en) |
| NZ (1) | NZ522317A (en) |
| WO (1) | WO2001080853A1 (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3221827A1 (en) * | 1982-06-09 | 1983-12-15 | DSO Pharmachim, Sofija | BIOSTIMULATING AGENT |
| US5834473A (en) * | 1993-04-29 | 1998-11-10 | Cultor, Ltd. | Method for treating coccidiosis |
| JP2003511094A (en) * | 1999-10-18 | 2003-03-25 | マッスルテク リサーチ アンド ディヴェロプメント インコーポレーション | Dietary supplements to increase lean body mass and physical fitness |
-
2001
- 2001-04-16 CA CA002405992A patent/CA2405992A1/en not_active Abandoned
- 2001-04-16 AU AU5359801A patent/AU5359801A/en active Pending
- 2001-04-16 AU AU2001253598A patent/AU2001253598B9/en not_active Ceased
- 2001-04-16 NZ NZ522317A patent/NZ522317A/en unknown
- 2001-04-16 WO PCT/US2001/012485 patent/WO2001080853A1/en active IP Right Grant
- 2001-04-16 GB GB0225557A patent/GB2377639B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB0225557D0 (en) | 2002-12-11 |
| GB2377639A8 (en) | 2003-11-27 |
| GB2377639B (en) | 2004-10-13 |
| GB2377639A (en) | 2003-01-22 |
| AU2001253598B9 (en) | 2006-02-23 |
| WO2001080853A1 (en) | 2001-11-01 |
| AU2001253598B2 (en) | 2005-12-15 |
| AU5359801A (en) | 2001-11-07 |
| CA2405992A1 (en) | 2001-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ASS | Change of ownership |
Owner name: ADVANTRX CORPORATION, US Free format text: OLD OWNER(S): HUMANETICS CORPORATION |
|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |