NZ513092A - System and method for noninvasive blood analyte measurements - Google Patents

System and method for noninvasive blood analyte measurements

Info

Publication number
NZ513092A
NZ513092A NZ513092A NZ51309200A NZ513092A NZ 513092 A NZ513092 A NZ 513092A NZ 513092 A NZ513092 A NZ 513092A NZ 51309200 A NZ51309200 A NZ 51309200A NZ 513092 A NZ513092 A NZ 513092A
Authority
NZ
New Zealand
Prior art keywords
calibration
blood analyte
categories
predictions
absorbance spectrum
Prior art date
Application number
NZ513092A
Inventor
Stephen Faithfully Malin
Timothy L Ruchti
Original Assignee
Instrumentation Metrics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/359,191 external-priority patent/US6280381B1/en
Application filed by Instrumentation Metrics Inc filed Critical Instrumentation Metrics Inc
Publication of NZ513092A publication Critical patent/NZ513092A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4785—Standardising light scatter apparatus; Standards therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1075—Measuring physical dimensions, e.g. size of the entire body or parts thereof for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A61B5/7267—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems involving training the classification device
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Analytical Chemistry (AREA)
  • Mathematical Physics (AREA)
  • Evolutionary Computation (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Fuzzy Systems (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

An intelligent system for measuring blood analytes noninvasively operates on a near infrared absorbance spectrum of in vivo skin tissue. A hierarchical architecture employs a pattern classification engine to adapt the calibration to the structural properties and physiological state of the subject as manifested in the absorbance spectrum. A priori information about the primary sources of sample variability are used to establish general categories of subjects. By applying calibration schemes specific to the various categories, the spectral interference is reduced resulting in improved prediction accuracy and parsimounious calibrations. Two classification rules are disclosed. The first rule assumes the classes are mutually exclusive and applies specific calibration models to the various subject categories. The second rule uses fuzzy set theory to develop calibration models and blood analyte predictions. Therefore, each calibration sample has the opportunity to influence more than one calibration model according to its class membership. Similarly, the predictions from more than one calibration are combined through defuzzification to produce the final blood analyte prediction.
NZ513092A 1999-01-22 2000-01-19 System and method for noninvasive blood analyte measurements NZ513092A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11688399P 1999-01-22 1999-01-22
US09/359,191 US6280381B1 (en) 1999-07-22 1999-07-22 Intelligent system for noninvasive blood analyte prediction
PCT/US2000/001378 WO2000042907A1 (en) 1999-01-22 2000-01-19 System and method for noninvasive blood analyte measurements

Publications (1)

Publication Number Publication Date
NZ513092A true NZ513092A (en) 2003-02-28

Family

ID=26814720

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ513092A NZ513092A (en) 1999-01-22 2000-01-19 System and method for noninvasive blood analyte measurements

Country Status (9)

Country Link
EP (1) EP1143850A1 (en)
JP (1) JP2002535023A (en)
AU (1) AU754677B2 (en)
BR (1) BR0008186A (en)
CA (1) CA2358473A1 (en)
IL (2) IL144401A0 (en)
NZ (1) NZ513092A (en)
TW (1) TW498156B (en)
WO (1) WO2000042907A1 (en)

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US6864978B1 (en) * 1999-07-22 2005-03-08 Sensys Medical, Inc. Method of characterizing spectrometer instruments and providing calibration models to compensate for instrument variation
US6512936B1 (en) * 1999-07-22 2003-01-28 Sensys Medical, Inc. Multi-tier method of classifying sample spectra for non-invasive blood analyte prediction
US6512937B2 (en) * 1999-07-22 2003-01-28 Sensys Medical, Inc. Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction
US6456870B1 (en) 1999-07-22 2002-09-24 Sensys Medical, Inc. Non-invasive method of determining skin thickness and characterizing layers of skin tissue in vivo
US20010041829A1 (en) * 2000-01-12 2001-11-15 Suresh Thennadil Non-invasive method of determining skin thickness and characterizing layers of skin tissue in vivo
EP1290428A1 (en) 2000-06-02 2003-03-12 Medicometrics APS Method and system for classifying a biological sample
AU2002249985B2 (en) * 2001-01-26 2005-11-17 Sensys Medical, Inc. Noninvasive measurement of glucose through the optical properties of tissue
WO2002069796A2 (en) * 2001-03-01 2002-09-12 University Of Massachusetts Correction of spectra for subject diversity
JP3931638B2 (en) 2001-11-15 2007-06-20 松下電工株式会社 Biological component determination device
US8718738B2 (en) 2002-03-08 2014-05-06 Glt Acquisition Corp. Method and apparatus for coupling a sample probe with a sample site
US7697966B2 (en) 2002-03-08 2010-04-13 Sensys Medical, Inc. Noninvasive targeting system method and apparatus
US8504128B2 (en) 2002-03-08 2013-08-06 Glt Acquisition Corp. Method and apparatus for coupling a channeled sample probe to tissue
EP1499231A4 (en) 2002-03-08 2007-09-26 Sensys Medical Inc Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy
JP3566276B1 (en) 2003-05-07 2004-09-15 株式会社日立製作所 Blood glucose meter
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JP3557424B1 (en) 2004-02-17 2004-08-25 株式会社日立製作所 Blood glucose meter
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US8868147B2 (en) 2004-04-28 2014-10-21 Glt Acquisition Corp. Method and apparatus for controlling positioning of a noninvasive analyzer sample probe
US7215983B2 (en) 2004-06-30 2007-05-08 Hitachi, Ltd. Blood sugar level measuring apparatus
US7251517B2 (en) 2004-06-30 2007-07-31 Hitachi, Ltd. Blood sugar level measuring apparatus
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US9918635B2 (en) 2008-12-23 2018-03-20 Roche Diabetes Care, Inc. Systems and methods for optimizing insulin dosage
CA2747332C (en) 2008-12-23 2015-01-27 F. Hoffmann-La Roche Ag Management method and system for implementation, execution, data collection, and data analysis of a structured collection procedure which runs on a collection device
US10437962B2 (en) 2008-12-23 2019-10-08 Roche Diabetes Care Inc Status reporting of a structured collection procedure
US10475529B2 (en) 2011-07-19 2019-11-12 Optiscan Biomedical Corporation Method and apparatus for analyte measurements using calibration sets
US9091676B2 (en) 2010-06-09 2015-07-28 Optiscan Biomedical Corp. Systems and methods for measuring multiple analytes in a sample
DE112010004184B4 (en) * 2009-10-29 2017-10-12 Hoya Corp. Auxiliary diagnostic device and auxiliary diagnostic method
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Also Published As

Publication number Publication date
WO2000042907A9 (en) 2001-10-25
JP2002535023A (en) 2002-10-22
TW498156B (en) 2002-08-11
AU2620900A (en) 2000-08-07
WO2000042907A1 (en) 2000-07-27
CA2358473A1 (en) 2000-07-27
AU754677B2 (en) 2002-11-21
BR0008186A (en) 2001-11-06
IL144401A (en) 2006-06-11
IL144401A0 (en) 2002-05-23
EP1143850A1 (en) 2001-10-17

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