NZ509188A - Process for the preparation of a 3(2H)-pyridazinone-4-substituted amino-5-choloro-derivative - Google Patents
Process for the preparation of a 3(2H)-pyridazinone-4-substituted amino-5-choloro-derivativeInfo
- Publication number
- NZ509188A NZ509188A NZ509188A NZ50918898A NZ509188A NZ 509188 A NZ509188 A NZ 509188A NZ 509188 A NZ509188 A NZ 509188A NZ 50918898 A NZ50918898 A NZ 50918898A NZ 509188 A NZ509188 A NZ 509188A
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- NZ
- New Zealand
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- formula
- compound
- reacting
- group
- obtained compound
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Abstract
Processes for the preparation of 5-chloro-4-{3-[N-[2-(3,4-dimethoxyphenyl)-ethyl]-N-methylamino]-propylamino}-3(2H)-pyridazinone of formula (I), which comprise: a1 reacting a compound of formula (II), wherein X stands for a leaving group, with N-methyl-homoveratryl amine of formula (VI), or a2 reacting a compound of formula (III), wherein R stands for lower alkanoyl, aroyl or aryl-(lower alkanoyl), adding a leaving group of formula X and reacting the obtained compound of formula (II) with the compound of formula (VI), or a3 reacting 4-(3-hydroxypropylamino)-3,5-dichloro-pyridazine of formula (IV) introducing a group of the formula R, reacting the obtained compound of formula (III) to produce a compound of formula (II), which is then reacted with a compound of formula (VI), or a4 reacting 3,4,5-trichloropyridazine of the formula (V) with 3-amino-1-propanol, reacting the obtained compound of formula (IV) adding a group of formula R, then reacting the obtained compound of formula (III) with an agent containing a leaving group of formula X, then reacting the obtained compound of formula (II) with a compound of formula (VI), or b1 removing the group of formula R from a compound of formula (IX), or b2 reacting the compound of formula (VIII) introducing a group of formula R and then removing R from the obtained compound of formula (IX), or b3 reacting a compound of formula (VII) with a compound of formula (VI), then reacting the obtained compound of formula (VIII) introducing a group of formula R and then removing R from the obtained compound of formula (IX), or b4 reacting a compound of formula (IV), adding a leaving group of formula X, reacting the obtained compound of formula (VII) with the compound of formula (VI), reacting the obtained compound of formula (VIII) introducing a group of formula R, then removing R from the obtained compound of formula (IX).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ509188A NZ509188A (en) | 1998-06-05 | 1998-06-05 | Process for the preparation of a 3(2H)-pyridazinone-4-substituted amino-5-choloro-derivative |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ509188A NZ509188A (en) | 1998-06-05 | 1998-06-05 | Process for the preparation of a 3(2H)-pyridazinone-4-substituted amino-5-choloro-derivative |
PCT/HU1998/000054 WO1999064402A1 (en) | 1998-06-05 | 1998-06-05 | Process for the preparation of a 3(2h)-pyridazinone- 4-substituted amino- 5-chloro- derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ509188A true NZ509188A (en) | 2002-12-20 |
Family
ID=19928308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ509188A NZ509188A (en) | 1998-06-05 | 1998-06-05 | Process for the preparation of a 3(2H)-pyridazinone-4-substituted amino-5-choloro-derivative |
Country Status (1)
Country | Link |
---|---|
NZ (1) | NZ509188A (en) |
-
1998
- 1998-06-05 NZ NZ509188A patent/NZ509188A/en unknown
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Legal Events
Date | Code | Title | Description |
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RENW | Renewal (renewal fees accepted) | ||
PSEA | Patent sealed | ||
RENW | Renewal (renewal fees accepted) |