NZ503315A - Using electrostatic chuck to apply pharmaceutical particles to a substrate - Google Patents
Using electrostatic chuck to apply pharmaceutical particles to a substrateInfo
- Publication number
- NZ503315A NZ503315A NZ503315A NZ50331597A NZ503315A NZ 503315 A NZ503315 A NZ 503315A NZ 503315 A NZ503315 A NZ 503315A NZ 50331597 A NZ50331597 A NZ 50331597A NZ 503315 A NZ503315 A NZ 503315A
- Authority
- NZ
- New Zealand
- Prior art keywords
- substrate
- particles
- chuck
- pharmaceutical
- dielectric layer
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Pharmaceutical particles are deposited on a substrate by attaching the substrate to an electrostatic chuck 910. The electrostatic chuck includes a dielectric layer 930, and a conductive layer 920, to which the substrate is attached. The particles are attracted to the substrate when a bias potential is applied to electrodes 940.
Claims (18)
1. A method of manufacturing a pharmaceutical composition comprising: (a) providing a pharmaceutical substrate; (b) holding the substrate to a chuck, the chuck comprising a planar dielectric layer and a planar conductive layer juxtaposed with the dielectric layer, the conductive layer being configured to electrostatically attract particles; and (c) electrostatically adhering pharmaceutically active particles to the substrate held by the chuck, said particles being held on the substrate by electrostatic forces.
2. The method according to claim 1, wherein the electrostatic chuck comprises a floating electrode and the particles are substantially adhered on an area of the substrate corresponding to the floating electrode.
3. The method of claim 2 including selecting a bias potential for application to the electrostatic chuck to establish the amount of the applied particles that are attached to the pharmaceutical substrate and applying the bias potential to the chuck.
4. The method according to one of claims 1 and 2, further comprising measuring the amount of particles deposited on the substrate by measuring ion currents induced by the particles deposited on a sensing electrode during application of the particles to the pharmaceutical substrate.
5. The method according to claim 1, wherein the pharmaceutical substrate is selected from the group consisting of an inhaler substrate and an edible polymeric substrate.
6. The method according to claim 4, further comprising terminating the application of the particles when the measured amount of deposited particles reaches a target amount. intellectual property office of nz office 1 0 AUG 2000 RECEIVED -34-
7. The method of claim 1, wherein the substrate is selected from the group consisting of a tablet, a capsule, a caplet, a suppository, a dressing, a bandage and a patch.
8. A particle deposition apparatus comprising: an electrostatic chuck comprising a planar dielectric layer and a planar conductive layer juxtaposed with the said dielectric layer and having at least one electrode for electrostatically attracting pharmaceutical active ingredient particles to the substrate; and means for securing the substrate to the chuck.
9. Apparatus according to claim 8, wherein the electrostatic chuck comprises a floating electrode.
10. Apparatus according to claim 8 or 9, further comprising a sensing electrode for measuring the amount of particles deposited on the substrate.
11. The particle deposition apparatus of claim 8, including means for controlling the amount of particles attracted to the substrate.
12. The particle deposition apparatus of claim 11, including means for depositing the controlled amount of particles at a plurality of discrete locations.
13. Apparatus according to any one of claims 8 to 12, further including a pharmaceutical substrate held on the chuck.
14. Apparatus according to claim 13, wherein the substrate is an inhaler pharmaceutical substrate.
15. Apparatus for manufacturing a pharmaceutical composition comprising: a chuck comprising a planar dielectric layer and a planar conductive layer juxtaposed with the dielectric layer, the conductive layer being configured to electrostatically attract particles; cllectual property office of nz 1 0 AUG 2000 RECEIVED / - -/ /r -35 a pharmaceutical substrate; and means for holding the substrate to the chuck, the chuck including means for electrostatically adhering pharmaceutical particles to the substrate.
16. A method according to claim 1 substantially as herein described or exemplified.
17. An apparatus according to claim 8 substantially as herein described or exemplified.
18. An apparatus according to claim 15 substantially as herein described or exemplified. DELSYS PHARMACEUTICAL CORPORATION By Their Attorneys HENRY HLJpHES Per: intellectual property office of nz 10 AUG 2000 RECEIVED 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/630,050 US5846595A (en) | 1996-04-09 | 1996-04-09 | Method of making pharmaceutical using electrostatic chuck |
| US08/661,210 US5858099A (en) | 1996-04-09 | 1996-06-10 | Electrostatic chucks and a particle deposition apparatus therefor |
| NZ332222A NZ332222A (en) | 1996-04-09 | 1997-04-09 | Particle deposition apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ503315A true NZ503315A (en) | 2001-08-31 |
Family
ID=27353866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ503315A NZ503315A (en) | 1996-04-09 | 1997-04-09 | Using electrostatic chuck to apply pharmaceutical particles to a substrate |
Country Status (1)
| Country | Link |
|---|---|
| NZ (1) | NZ503315A (en) |
-
1997
- 1997-04-09 NZ NZ503315A patent/NZ503315A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ASS | Change of ownership |
Owner name: DELSYS PHARMACEUTICAL CORPORATION, US Free format text: OLD OWNER(S): DELSYS PHARMACEUTICAL CORPORATION |
|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |